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Conserved domains on  [gi|397140081|ref|XP_003846529|]
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keratin-associated protein 9-6 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-173 1.85e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.12  E-value: 1.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 397140081   37 CCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPTCVTSCyQPSCCSTPCCQPICCGSSCCGQTSCGSSCCQPSSCAPIY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTCQPCC-QTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 397140081  116 CRRTCYHPTSVYLPGCLNQSCGSSCCQ------PCCRPACCETTCCrttcfQPTCVTSCCQPAC 173
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-173 1.85e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.12  E-value: 1.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 397140081   37 CCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPTCVTSCyQPSCCSTPCCQPICCGSSCCGQTSCGSSCCQPSSCAPIY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTCQPCC-QTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 397140081  116 CRRTCYHPTSVYLPGCLNQSCGSSCCQ------PCCRPACCETTCCrttcfQPTCVTSCCQPAC 173
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
36-96 3.72e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.93  E-value: 3.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 397140081  36 PCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQPTCVTSCYQPSCCSTPCCQPICCGSSCC 96
Cdd:COG4624   39 PEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPC 99
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-173 1.85e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.12  E-value: 1.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 397140081   37 CCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPTCVTSCyQPSCCSTPCCQPICCGSSCCGQTSCGSSCCQPSSCAPIY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTCQPCC-QTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 397140081  116 CRRTCYHPTSVYLPGCLNQSCGSSCCQ------PCCRPACCETTCCrttcfQPTCVTSCCQPAC 173
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 31-145 4.06e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 58.26  E-value: 4.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 397140081   31 TCSSTPCCQPSCCVSSCCQP-CCHPTCCQNTC---CRTTCCQPTCV-TSCYQPSCCSTPCCQPICCGSSCCGQTSCGSSC 105
Cdd:pfam01500  28 CCCQSSCCRPSCCQTSCCQPtTFQSSCCRPTCqpcCQTSCCQPTCCqTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDC 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 397140081  106 CQPSSCAPIYCRRTCYHPT-----SVYLPGCLNQSCGSSCCQPCC 145
Cdd:pfam01500 108 RVEGTCLPPCCVVSCTPPTccqlhHAQASCCRPSYCGQSCCRPAC 152
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
80-124 2.97e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.46  E-value: 2.97e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 397140081   80 CCSTPCCQPICCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCYHPT 124
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
37-79 1.40e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 397140081   37 CCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPTC-VTSCYQPS 79
Cdd:pfam13885   1 CCQPSCCQPSCCQPsCCQPSCCQPSCCQPSCCRPSCcRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
32-75 1.94e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.15  E-value: 1.94e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 397140081   32 CSSTPCCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPTCVTSC 75
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPsCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
71-114 7.87e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 7.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 397140081   71 CVTSCYQPSCCSTPCCQPICCGSSCCGQTSCGSSCCQPSSCAPI 114
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
30-70 1.46e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.84  E-value: 1.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 397140081   30 TTCSSTPCCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPT 70
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPsCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
56-109 2.96e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.07  E-value: 2.96e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 397140081   56 CCQNTCCRTTCCQPtcvtSCYQPSCCSTPCCQPICCGSSCcgqtsCGSSCCQPS 109
Cdd:pfam13885   1 CCQPSCCQPSCCQP----SCCQPSCCQPSCCQPSCCRPSC-----CRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 31-145 3.55e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 42.11  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 397140081   31 TCSSTPCCQPSCCVSSCCQP-CCHPTCCQNTCC--RTTCCQPTCVTSCYQPSCCSTPCCQPICCGSSCCGQTSCGSSCCQ 107
Cdd:pfam05287  59 TCGEPTSCQTSSCEPCTSSTsYCVPSPCQRSCYspRTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFR 138

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 397140081  108 PSSCAPIYCRRTCYHPTSVYLPGCLNQSCGSSCCQPCC 145
Cdd:pfam05287 139 PLGCLSKGFQSLGYGSSFCRPSYVSSRSYQPSCFRPSC 176
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 32-166 1.65e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 40.18  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 397140081   32 CSSTPCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQPT------CVTSCYQPSC-CSTPCCQPICCGSSCCGQTSCGSS 104
Cdd:pfam05287  41 CSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSycvpspCQRSCYSPRTsCVCSPCQTTSAGSLGFGSSSCQSL 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 397140081  105 CCQPSSCAPIYCRRTCYHPTSVYLPGCLNQSCGSSCCQPCCrpacCETTCCRTTCFQPTCVT 166
Cdd:pfam05287 121 GYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSY----VSSRSYQPSCFRPSCGS 178
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
90-144 1.16e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.44  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 397140081   90 CCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCYHPTsvylpgclnqSCGSSCCQPC 144
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPS----------CCRSSCCQPT 45
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
36-96 3.72e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.93  E-value: 3.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 397140081  36 PCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQPTCVTSCYQPSCCSTPCCQPICCGSSCC 96
Cdd:COG4624   39 PEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPC 99
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
37-85 4.92e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 36.84  E-value: 4.92e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 397140081  37 CCQPSCCvsSCCQPCCHPTCCQNTCCRTT-----CCQPTCVTSCYQPSCCSTPC 85
Cdd:COG3901  631 RRECCCG--CCCCCCKCCCIVIIIDGIIIineccCCCCLCCRRCQDDPLCPPRI 682
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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