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Concise Results
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Full Results
hypothetical protein NCAS_0C04950 [Naumovozyma castellii]
Protein Classification
insulinase family protein ( domain architecture ID 1002320 )
insulinase family protein (peptidase M16) is a zinc-dependent peptidase that cleaves small peptides close to a terminus, often including bonds on the amino side of basic residues such as arginine
List of domain hits
Name
Accession
Description
Interval
E-value
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
28-455
1.64e-29
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 122.72
E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 28 GL QLVH V DHKSS P L V QGYFA V GT ---- E C P NDS G VP H T LEH LI F M G S K QHPYKGL --- L DTV G nlcm S S T NA W T AT D Q TV 100
Cdd:COG0612 23 GL RVIL V PDPEA P V V SVRLW V RV gsrd E P P GKT G LA H F LEH ML F K G T K KRSAGEI aee L EAL G ---- G S L NA F T SF D Y TV 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 101 Y T L TSAG w KGFSKI L PAYLNHI L F PT LTDDA cttevyh VDP E dlsd K GVV FS E MEAI E SQSWFVTMLEKQRLMFP r GSG Y 180
Cdd:COG0612 99 Y Y L SVLS - EDLELA L ELLADRL L N PT FDEEE ------- LER E ---- R GVV LE E IRRY E DDPDGLAFEALLAALYG - DHP Y 165
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 181 RSETG G LTNNLRDL T N E EIKE F H K AN Y SSD N LC L IIC G N V PES E L L EI V QNWDNS LP DKDLTRKKR P fldsvdf QI P KNR 260
Cdd:COG0612 166 GRPII G TEESIEAI T R E DLRA F Y K RY Y RPN N AV L VVV G D V DPE E V L AL V EKYFGD LP AGPAPPRPD P ------- AE P PQT 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 261 A elv EST V EFPEL D ES Q GE ILL SWI G ESYLS f R D DL A VSM L LDYFTESALAPFTKQ L V E i DDP LA N S TDYWTDDFMRTII 340
Cdd:COG0612 239 G --- PRR V VVDDP D AE Q AH ILL GYP G PARDD - P D YY A LDV L NEILGGGFSSRLFQE L R E - KKG LA Y S VGSSFSPYRDAGL 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 341 n LG I HGVP ---- T E KLTETKNKV L DI L KNHEI --- D L K R IRQVVDNG kwe YV L RC E K N GD st L SQAAITDF LYG NPDGSS 413
Cdd:COG0612 314 - FT I YAGT apdk L E EALAAILEE L ER L AKEGV tee E L E R AKNQLLGS --- LA L SL E S N SG -- L ASQLGRYE LYG GDLDYL 387
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 366992167 414 L E astkdls DFDDLSNW T ITQWKELVDRIFVSNKP V I VV GK P 455
Cdd:COG0612 388 E E ------- YLERIEAV T AEDVQAVARKYLDPDNL V V VV VG P 422
Cym1 super family
cl34067 Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
26-979
9.01e-19
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];
COG1026 :Pssm-ID: 440649 [Multi-domain]
Cd Length: 974
Bit Score: 92.17
E-value: 9.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 26 R TG LQ L V H VDHKSSPL V qgy F AVG -- T E c P N DS - GV P H T LEH LIFM GS KQH P -------- Y KG L L D T V gnlc M sst NA W T 94
Cdd:COG1026 34 K TG AR L L H LANDDDNK V --- F SIA fr T P - P E DS t GV A H I LEH SVLC GS RKY P vkdpffel L KG S L N T F ---- L --- NA M T 102
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 95 AT D Q T V Y TLT S AGW K G F SKILPA YL NHIL FP T L TDDACTT E VYHVDP E DLSD ---- KGVV FS EM E ---- AIE S QS W fvtm 166
Cdd:COG1026 103 YS D K T A Y PVA S RNE K D F YNLMDV YL DAVF FP N L DPLIFAQ E GWRYEL E EPDS plty KGVV YN EM K gams SPD S VL W ---- 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 167 lek QR L M --- FP r GSG Y RSET GG LTNNLR DLT N E EIKE FHK AN Y SSD N l CL I I - C G NVPES E L L EIVQ nw DNS L pd KDLT 242
Cdd:COG1026 179 --- RA L Q ksl FP - DTT Y GYNS GG DPEVIP DLT Y E QFLA FHK KY Y HPS N - AY I Y l Y G DIDAE E H L AFLD -- EEY L -- SRFE 249
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 243 R KK rpflds VD FQI P -- K NRAELV E STVEF P - ELD E SQGE --- IL L S W - I GES y LSFRDD LA VSM L LDYFTESALA P FT K 315
Cdd:COG1026 250 R LE ------ VD SEV P dq K RFSAPR E VEETY P v AEE E DTEN kty LS L N W l L GES - TDLEES LA LQL L SYVLLGNSAS P LK K 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 316 Q L ve I D DP L ANSTDYWTD D FM R - TIINL G IH G VPT EK LTETKNKV L DI L knheidlkri RQV V DN G ----------- KW E 383
Cdd:COG1026 323 A L -- L D SG L GKDVSGGLE D SL R q PVFSI G LK G SEP EK AEAFEKLI L ET L ---------- EKL V EE G idkelleaaln QL E 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 384 YV LR c E KN G D S T ----- L SQA A ITDF LY - G N P DGS ----- S LE ASTKDLS D FDD lsnwtitq WKE L VDRIFVS N K - P V IV 451
Cdd:COG1026 391 FS LR - E ID G G S Y pyglq L ILR A LDSW LY g G D P LAL lryep A LE KLREKIK D PGY -------- FEN L IRKYLLD N P h R V LL 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 452 VG KP SSD L YG R L E - AEK DQ L -- IK DRE S Q ygkegt AKLHDLL E SAQD hnnkpipesl L H E F - NI E NPEKTVDFIST L GI t 527
Cdd:COG1026 462 TL KP DPG L AE R K E a AEK EK L aa IK ASL S E ------ EEKQAII E QTKA ---------- L K E R q EQ E DSPEALATLPK L TL - 524
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 528 tldnyefnnls N D LT K H V LK ----- SKPD G F P LFM H l EH F PSQFIE L HCLLNSTCIKD t S LLPY YHIFDG L FS mpm KSD T 602
Cdd:COG1026 525 ----------- E D IP K E V KE iplee EELG G V P VLF H - DL F TNGIVY L DLYFDLPALPE - E LLPY LPLLTD L LG --- ELG T 588
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 603 DEK ii SFE E VVAKLKSE T -- VDTQITLGL N ASCPELVD -- F RIRC K -- SSDYF K AVNWI K HC L FDMI FD E K rvsvlle NY 676
Cdd:COG1026 589 GKY -- DYL E LSNEIAAY T gg ISASTSVYT N IDDVQEYR py F VVSG K al ARNLD K LFELL K EI L LNTR FD D K ------- KR 659
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 677 L NSI V - EL K -- R E GDIM ----------- LDSLKSRNI Y T E R sfkksadply VE G I ----- L EEVLADIE ng DFKSKVLPR 737
Cdd:COG1026 660 L REL V a QI K ar L E QSLT gsghslamsra SSYFSPAAA Y S E Q ---------- LS G L syyrf L KDLEENLD -- EKLEELAEK 727
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 738 L ETMRTQ L R e N FNKFH I LIF G D --- ISKISTNVYTPWQN L veqfgvipanyevki P PAPRPLNSISSLCQKPA E r AY I IT 814
Cdd:COG1026 728 L QELADK L F - N RPNLL I SVT G E eee LEAFKKALEAFIAS L --------------- P AGTAAPFKYPFDAEPKN E - GW I TS 790
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 815 TP -------------- ASDSAYMTT L TS I pfdldyndskypavs L ASE YL qcvegpf W KG IR GS G L AYG ANMIKMTEINS 880
Cdd:COG1026 791 SQ vnyvakaynfvplg HEYAGALLV L AG I --------------- L RNG YL ------- W NK IR VQ G G AYG GGASFDSLSGN 848
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 881 WG F NI YR G --- TDIIKC Y QAGKQIVEDYA ngiek FDPQLIQG A LNSI I NR L ATVEN gyf A AG IA K YVD - DF L YK R G P NFN 956
Cdd:COG1026 849 FR F YS YR D pnl KETLDV Y DEAPDWLRNFD ----- LSERELEK A IIGT I SS L DKPLS --- P AG KG K RAF h RY L SG R T P EDR 920
1050 1060
....*....|....*....|...
gi 366992167 957 K KF LERLAKV T AD D MQK V MKE YL 979
Cdd:COG1026 921 Q KF RDEILST T LE D LRR V AEL YL 943
Name
Accession
Description
Interval
E-value
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
28-455
1.64e-29
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 122.72
E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 28 GL QLVH V DHKSS P L V QGYFA V GT ---- E C P NDS G VP H T LEH LI F M G S K QHPYKGL --- L DTV G nlcm S S T NA W T AT D Q TV 100
Cdd:COG0612 23 GL RVIL V PDPEA P V V SVRLW V RV gsrd E P P GKT G LA H F LEH ML F K G T K KRSAGEI aee L EAL G ---- G S L NA F T SF D Y TV 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 101 Y T L TSAG w KGFSKI L PAYLNHI L F PT LTDDA cttevyh VDP E dlsd K GVV FS E MEAI E SQSWFVTMLEKQRLMFP r GSG Y 180
Cdd:COG0612 99 Y Y L SVLS - EDLELA L ELLADRL L N PT FDEEE ------- LER E ---- R GVV LE E IRRY E DDPDGLAFEALLAALYG - DHP Y 165
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 181 RSETG G LTNNLRDL T N E EIKE F H K AN Y SSD N LC L IIC G N V PES E L L EI V QNWDNS LP DKDLTRKKR P fldsvdf QI P KNR 260
Cdd:COG0612 166 GRPII G TEESIEAI T R E DLRA F Y K RY Y RPN N AV L VVV G D V DPE E V L AL V EKYFGD LP AGPAPPRPD P ------- AE P PQT 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 261 A elv EST V EFPEL D ES Q GE ILL SWI G ESYLS f R D DL A VSM L LDYFTESALAPFTKQ L V E i DDP LA N S TDYWTDDFMRTII 340
Cdd:COG0612 239 G --- PRR V VVDDP D AE Q AH ILL GYP G PARDD - P D YY A LDV L NEILGGGFSSRLFQE L R E - KKG LA Y S VGSSFSPYRDAGL 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 341 n LG I HGVP ---- T E KLTETKNKV L DI L KNHEI --- D L K R IRQVVDNG kwe YV L RC E K N GD st L SQAAITDF LYG NPDGSS 413
Cdd:COG0612 314 - FT I YAGT apdk L E EALAAILEE L ER L AKEGV tee E L E R AKNQLLGS --- LA L SL E S N SG -- L ASQLGRYE LYG GDLDYL 387
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 366992167 414 L E astkdls DFDDLSNW T ITQWKELVDRIFVSNKP V I VV GK P 455
Cdd:COG0612 388 E E ------- YLERIEAV T AEDVQAVARKYLDPDNL V V VV VG P 422
Cym1
COG1026 Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
26-979
9.01e-19
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440649 [Multi-domain]
Cd Length: 974
Bit Score: 92.17
E-value: 9.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 26 R TG LQ L V H VDHKSSPL V qgy F AVG -- T E c P N DS - GV P H T LEH LIFM GS KQH P -------- Y KG L L D T V gnlc M sst NA W T 94
Cdd:COG1026 34 K TG AR L L H LANDDDNK V --- F SIA fr T P - P E DS t GV A H I LEH SVLC GS RKY P vkdpffel L KG S L N T F ---- L --- NA M T 102
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 95 AT D Q T V Y TLT S AGW K G F SKILPA YL NHIL FP T L TDDACTT E VYHVDP E DLSD ---- KGVV FS EM E ---- AIE S QS W fvtm 166
Cdd:COG1026 103 YS D K T A Y PVA S RNE K D F YNLMDV YL DAVF FP N L DPLIFAQ E GWRYEL E EPDS plty KGVV YN EM K gams SPD S VL W ---- 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 167 lek QR L M --- FP r GSG Y RSET GG LTNNLR DLT N E EIKE FHK AN Y SSD N l CL I I - C G NVPES E L L EIVQ nw DNS L pd KDLT 242
Cdd:COG1026 179 --- RA L Q ksl FP - DTT Y GYNS GG DPEVIP DLT Y E QFLA FHK KY Y HPS N - AY I Y l Y G DIDAE E H L AFLD -- EEY L -- SRFE 249
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 243 R KK rpflds VD FQI P -- K NRAELV E STVEF P - ELD E SQGE --- IL L S W - I GES y LSFRDD LA VSM L LDYFTESALA P FT K 315
Cdd:COG1026 250 R LE ------ VD SEV P dq K RFSAPR E VEETY P v AEE E DTEN kty LS L N W l L GES - TDLEES LA LQL L SYVLLGNSAS P LK K 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 316 Q L ve I D DP L ANSTDYWTD D FM R - TIINL G IH G VPT EK LTETKNKV L DI L knheidlkri RQV V DN G ----------- KW E 383
Cdd:COG1026 323 A L -- L D SG L GKDVSGGLE D SL R q PVFSI G LK G SEP EK AEAFEKLI L ET L ---------- EKL V EE G idkelleaaln QL E 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 384 YV LR c E KN G D S T ----- L SQA A ITDF LY - G N P DGS ----- S LE ASTKDLS D FDD lsnwtitq WKE L VDRIFVS N K - P V IV 451
Cdd:COG1026 391 FS LR - E ID G G S Y pyglq L ILR A LDSW LY g G D P LAL lryep A LE KLREKIK D PGY -------- FEN L IRKYLLD N P h R V LL 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 452 VG KP SSD L YG R L E - AEK DQ L -- IK DRE S Q ygkegt AKLHDLL E SAQD hnnkpipesl L H E F - NI E NPEKTVDFIST L GI t 527
Cdd:COG1026 462 TL KP DPG L AE R K E a AEK EK L aa IK ASL S E ------ EEKQAII E QTKA ---------- L K E R q EQ E DSPEALATLPK L TL - 524
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 528 tldnyefnnls N D LT K H V LK ----- SKPD G F P LFM H l EH F PSQFIE L HCLLNSTCIKD t S LLPY YHIFDG L FS mpm KSD T 602
Cdd:COG1026 525 ----------- E D IP K E V KE iplee EELG G V P VLF H - DL F TNGIVY L DLYFDLPALPE - E LLPY LPLLTD L LG --- ELG T 588
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 603 DEK ii SFE E VVAKLKSE T -- VDTQITLGL N ASCPELVD -- F RIRC K -- SSDYF K AVNWI K HC L FDMI FD E K rvsvlle NY 676
Cdd:COG1026 589 GKY -- DYL E LSNEIAAY T gg ISASTSVYT N IDDVQEYR py F VVSG K al ARNLD K LFELL K EI L LNTR FD D K ------- KR 659
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 677 L NSI V - EL K -- R E GDIM ----------- LDSLKSRNI Y T E R sfkksadply VE G I ----- L EEVLADIE ng DFKSKVLPR 737
Cdd:COG1026 660 L REL V a QI K ar L E QSLT gsghslamsra SSYFSPAAA Y S E Q ---------- LS G L syyrf L KDLEENLD -- EKLEELAEK 727
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 738 L ETMRTQ L R e N FNKFH I LIF G D --- ISKISTNVYTPWQN L veqfgvipanyevki P PAPRPLNSISSLCQKPA E r AY I IT 814
Cdd:COG1026 728 L QELADK L F - N RPNLL I SVT G E eee LEAFKKALEAFIAS L --------------- P AGTAAPFKYPFDAEPKN E - GW I TS 790
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 815 TP -------------- ASDSAYMTT L TS I pfdldyndskypavs L ASE YL qcvegpf W KG IR GS G L AYG ANMIKMTEINS 880
Cdd:COG1026 791 SQ vnyvakaynfvplg HEYAGALLV L AG I --------------- L RNG YL ------- W NK IR VQ G G AYG GGASFDSLSGN 848
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 881 WG F NI YR G --- TDIIKC Y QAGKQIVEDYA ngiek FDPQLIQG A LNSI I NR L ATVEN gyf A AG IA K YVD - DF L YK R G P NFN 956
Cdd:COG1026 849 FR F YS YR D pnl KETLDV Y DEAPDWLRNFD ----- LSERELEK A IIGT I SS L DKPLS --- P AG KG K RAF h RY L SG R T P EDR 920
1050 1060
....*....|....*....|...
gi 366992167 957 K KF LERLAKV T AD D MQK V MKE YL 979
Cdd:COG1026 921 Q KF RDEILST T LE D LRR V AEL YL 943
PTZ00432
PTZ00432 falcilysin; Provisional
3-380
2.74e-16
falcilysin; Provisional
Pssm-ID: 240416 [Multi-domain]
Cd Length: 1119
Bit Score: 84.08
E-value: 2.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 3 FN K LIS fql E Y A P QYHL -- T K Y ISPR TGLQ LVHVDHKS S PLVQGY F AVGTEC P -- ND S G V PH T LEH LIFM GSK QHP YK -- 76
Cdd:PTZ00432 76 YE K IEK --- R Y L P DFGM va T V Y SHKK TGLQ VISLKTND S SGKEMC F DFYVPT P ph ND K G I PH I LEH SVLS GSK KYN YK ds 152
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 77 - G LL dt V GNLCM S ST NA W T AT D Q T V Y TLT S AGW K G F SKILPA Y LNHILF P TLTD D ACT -- T E VY H VDPED L S D K ------ 147
Cdd:PTZ00432 153 f S LL -- V QGGFN S FL NA Y T FK D R T S Y LFA S TNE K D F YNTADV Y MDSVFQ P NILE D KDI fk Q E GW H YKVTK L K D D eknade 230
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 148 ------------ G V V F SEM E - AIESQSW F VTMLEK Q R L M fpr GSG Y RSET GG LTNNLRD LT N EE IK EF H K AN Y SSDNLCL 214
Cdd:PTZ00432 231 lgnvhdrhvsys G I V Y SEM K k RFSDPLS F GYSVIY Q N L F --- SNV Y KYDS GG DPKDIVE LT Y EE LV EF Y K TY Y GPKTATV 307
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 215 IIC G NVPES E L LE I V Q N WDNSL P --- DKDL T RKKRPFLDSVDFQIP K NRAEL V ES tv E F PELD E SQGEILLS - W I ----- 285
Cdd:PTZ00432 308 YFY G PNDVT E R LE F V D N YLTKH P ktg QLSH T AYREDADENLLYEEY K DKPKH V KK -- K F SSHS E EEENLMSV s W L lnpkh 385
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 286 ------ GE S YLSFR D D LA VSM L LDYFTESALAPFT K Q L ve ID DP L ANST -- DYWT D D F MRT I INL G IH G V pte K L T ET K N 357
Cdd:PTZ00432 386 ngskdy DK S LIDPV D Y LA LLV L NYLLLGTPESVLY K A L -- ID SG L GKKV vg SGLD D Y F KQS I FSI G LK G I --- K E T NE K R 460
410 420
....*....|....*....|...
gi 366992167 358 K VLDILKNHEID L KRIRQ VV DN G 380
Cdd:PTZ00432 461 K DKVHYTFEKVV L NALTK VV TE G 483
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
193-365
4.87e-16
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 77.05
E-value: 4.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 193 D LT N E EIKE F H K AN YS S DN LC L I I C G N V PES ELL EIVQNWDNS LP DKDLTRKKR P fldsvdfqi P KNR A E L VEST V EF P E 272
Cdd:pfam05193 1 S LT R E DLRD F Y K KH YS P DN MV L V I V G D V DHE ELL DLAEKYFGD LP ASPKGKPRP P --------- P LEP A K L KGRE V VV P K 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 273 L DE S Q GEIL L SWI G ESYLSFR D D LA VSM L LDYFTESALAPFTKQ L V E i DDP LA N S TDYWT D DF - MRTIINLGI h G V PT E K 351
Cdd:pfam05193 72 K DE P Q AHLA L AFP G PPLNNDE D S LA LDV L NELLGGGMSSRLFQE L R E - KEG LA Y S VSSFN D SY s DSGLFGIYA - T V DP E N 149
170
....*....|....
gi 366992167 352 LT E TKNKV L DI L KN 365
Cdd:pfam05193 150 VD E VIELI L EE L EK 163
Name
Accession
Description
Interval
E-value
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
28-455
1.64e-29
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 122.72
E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 28 GL QLVH V DHKSS P L V QGYFA V GT ---- E C P NDS G VP H T LEH LI F M G S K QHPYKGL --- L DTV G nlcm S S T NA W T AT D Q TV 100
Cdd:COG0612 23 GL RVIL V PDPEA P V V SVRLW V RV gsrd E P P GKT G LA H F LEH ML F K G T K KRSAGEI aee L EAL G ---- G S L NA F T SF D Y TV 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 101 Y T L TSAG w KGFSKI L PAYLNHI L F PT LTDDA cttevyh VDP E dlsd K GVV FS E MEAI E SQSWFVTMLEKQRLMFP r GSG Y 180
Cdd:COG0612 99 Y Y L SVLS - EDLELA L ELLADRL L N PT FDEEE ------- LER E ---- R GVV LE E IRRY E DDPDGLAFEALLAALYG - DHP Y 165
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 181 RSETG G LTNNLRDL T N E EIKE F H K AN Y SSD N LC L IIC G N V PES E L L EI V QNWDNS LP DKDLTRKKR P fldsvdf QI P KNR 260
Cdd:COG0612 166 GRPII G TEESIEAI T R E DLRA F Y K RY Y RPN N AV L VVV G D V DPE E V L AL V EKYFGD LP AGPAPPRPD P ------- AE P PQT 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 261 A elv EST V EFPEL D ES Q GE ILL SWI G ESYLS f R D DL A VSM L LDYFTESALAPFTKQ L V E i DDP LA N S TDYWTDDFMRTII 340
Cdd:COG0612 239 G --- PRR V VVDDP D AE Q AH ILL GYP G PARDD - P D YY A LDV L NEILGGGFSSRLFQE L R E - KKG LA Y S VGSSFSPYRDAGL 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 341 n LG I HGVP ---- T E KLTETKNKV L DI L KNHEI --- D L K R IRQVVDNG kwe YV L RC E K N GD st L SQAAITDF LYG NPDGSS 413
Cdd:COG0612 314 - FT I YAGT apdk L E EALAAILEE L ER L AKEGV tee E L E R AKNQLLGS --- LA L SL E S N SG -- L ASQLGRYE LYG GDLDYL 387
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 366992167 414 L E astkdls DFDDLSNW T ITQWKELVDRIFVSNKP V I VV GK P 455
Cdd:COG0612 388 E E ------- YLERIEAV T AEDVQAVARKYLDPDNL V V VV VG P 422
Cym1
COG1026 Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
26-979
9.01e-19
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440649 [Multi-domain]
Cd Length: 974
Bit Score: 92.17
E-value: 9.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 26 R TG LQ L V H VDHKSSPL V qgy F AVG -- T E c P N DS - GV P H T LEH LIFM GS KQH P -------- Y KG L L D T V gnlc M sst NA W T 94
Cdd:COG1026 34 K TG AR L L H LANDDDNK V --- F SIA fr T P - P E DS t GV A H I LEH SVLC GS RKY P vkdpffel L KG S L N T F ---- L --- NA M T 102
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 95 AT D Q T V Y TLT S AGW K G F SKILPA YL NHIL FP T L TDDACTT E VYHVDP E DLSD ---- KGVV FS EM E ---- AIE S QS W fvtm 166
Cdd:COG1026 103 YS D K T A Y PVA S RNE K D F YNLMDV YL DAVF FP N L DPLIFAQ E GWRYEL E EPDS plty KGVV YN EM K gams SPD S VL W ---- 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 167 lek QR L M --- FP r GSG Y RSET GG LTNNLR DLT N E EIKE FHK AN Y SSD N l CL I I - C G NVPES E L L EIVQ nw DNS L pd KDLT 242
Cdd:COG1026 179 --- RA L Q ksl FP - DTT Y GYNS GG DPEVIP DLT Y E QFLA FHK KY Y HPS N - AY I Y l Y G DIDAE E H L AFLD -- EEY L -- SRFE 249
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 243 R KK rpflds VD FQI P -- K NRAELV E STVEF P - ELD E SQGE --- IL L S W - I GES y LSFRDD LA VSM L LDYFTESALA P FT K 315
Cdd:COG1026 250 R LE ------ VD SEV P dq K RFSAPR E VEETY P v AEE E DTEN kty LS L N W l L GES - TDLEES LA LQL L SYVLLGNSAS P LK K 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 316 Q L ve I D DP L ANSTDYWTD D FM R - TIINL G IH G VPT EK LTETKNKV L DI L knheidlkri RQV V DN G ----------- KW E 383
Cdd:COG1026 323 A L -- L D SG L GKDVSGGLE D SL R q PVFSI G LK G SEP EK AEAFEKLI L ET L ---------- EKL V EE G idkelleaaln QL E 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 384 YV LR c E KN G D S T ----- L SQA A ITDF LY - G N P DGS ----- S LE ASTKDLS D FDD lsnwtitq WKE L VDRIFVS N K - P V IV 451
Cdd:COG1026 391 FS LR - E ID G G S Y pyglq L ILR A LDSW LY g G D P LAL lryep A LE KLREKIK D PGY -------- FEN L IRKYLLD N P h R V LL 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 452 VG KP SSD L YG R L E - AEK DQ L -- IK DRE S Q ygkegt AKLHDLL E SAQD hnnkpipesl L H E F - NI E NPEKTVDFIST L GI t 527
Cdd:COG1026 462 TL KP DPG L AE R K E a AEK EK L aa IK ASL S E ------ EEKQAII E QTKA ---------- L K E R q EQ E DSPEALATLPK L TL - 524
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 528 tldnyefnnls N D LT K H V LK ----- SKPD G F P LFM H l EH F PSQFIE L HCLLNSTCIKD t S LLPY YHIFDG L FS mpm KSD T 602
Cdd:COG1026 525 ----------- E D IP K E V KE iplee EELG G V P VLF H - DL F TNGIVY L DLYFDLPALPE - E LLPY LPLLTD L LG --- ELG T 588
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 603 DEK ii SFE E VVAKLKSE T -- VDTQITLGL N ASCPELVD -- F RIRC K -- SSDYF K AVNWI K HC L FDMI FD E K rvsvlle NY 676
Cdd:COG1026 589 GKY -- DYL E LSNEIAAY T gg ISASTSVYT N IDDVQEYR py F VVSG K al ARNLD K LFELL K EI L LNTR FD D K ------- KR 659
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 677 L NSI V - EL K -- R E GDIM ----------- LDSLKSRNI Y T E R sfkksadply VE G I ----- L EEVLADIE ng DFKSKVLPR 737
Cdd:COG1026 660 L REL V a QI K ar L E QSLT gsghslamsra SSYFSPAAA Y S E Q ---------- LS G L syyrf L KDLEENLD -- EKLEELAEK 727
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 738 L ETMRTQ L R e N FNKFH I LIF G D --- ISKISTNVYTPWQN L veqfgvipanyevki P PAPRPLNSISSLCQKPA E r AY I IT 814
Cdd:COG1026 728 L QELADK L F - N RPNLL I SVT G E eee LEAFKKALEAFIAS L --------------- P AGTAAPFKYPFDAEPKN E - GW I TS 790
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 815 TP -------------- ASDSAYMTT L TS I pfdldyndskypavs L ASE YL qcvegpf W KG IR GS G L AYG ANMIKMTEINS 880
Cdd:COG1026 791 SQ vnyvakaynfvplg HEYAGALLV L AG I --------------- L RNG YL ------- W NK IR VQ G G AYG GGASFDSLSGN 848
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 881 WG F NI YR G --- TDIIKC Y QAGKQIVEDYA ngiek FDPQLIQG A LNSI I NR L ATVEN gyf A AG IA K YVD - DF L YK R G P NFN 956
Cdd:COG1026 849 FR F YS YR D pnl KETLDV Y DEAPDWLRNFD ----- LSERELEK A IIGT I SS L DKPLS --- P AG KG K RAF h RY L SG R T P EDR 920
1050 1060
....*....|....*....|...
gi 366992167 957 K KF LERLAKV T AD D MQK V MKE YL 979
Cdd:COG1026 921 Q KF RDEILST T LE D LRR V AEL YL 943
PTZ00432
PTZ00432 falcilysin; Provisional
3-380
2.74e-16
falcilysin; Provisional
Pssm-ID: 240416 [Multi-domain]
Cd Length: 1119
Bit Score: 84.08
E-value: 2.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 3 FN K LIS fql E Y A P QYHL -- T K Y ISPR TGLQ LVHVDHKS S PLVQGY F AVGTEC P -- ND S G V PH T LEH LIFM GSK QHP YK -- 76
Cdd:PTZ00432 76 YE K IEK --- R Y L P DFGM va T V Y SHKK TGLQ VISLKTND S SGKEMC F DFYVPT P ph ND K G I PH I LEH SVLS GSK KYN YK ds 152
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 77 - G LL dt V GNLCM S ST NA W T AT D Q T V Y TLT S AGW K G F SKILPA Y LNHILF P TLTD D ACT -- T E VY H VDPED L S D K ------ 147
Cdd:PTZ00432 153 f S LL -- V QGGFN S FL NA Y T FK D R T S Y LFA S TNE K D F YNTADV Y MDSVFQ P NILE D KDI fk Q E GW H YKVTK L K D D eknade 230
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 148 ------------ G V V F SEM E - AIESQSW F VTMLEK Q R L M fpr GSG Y RSET GG LTNNLRD LT N EE IK EF H K AN Y SSDNLCL 214
Cdd:PTZ00432 231 lgnvhdrhvsys G I V Y SEM K k RFSDPLS F GYSVIY Q N L F --- SNV Y KYDS GG DPKDIVE LT Y EE LV EF Y K TY Y GPKTATV 307
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 215 IIC G NVPES E L LE I V Q N WDNSL P --- DKDL T RKKRPFLDSVDFQIP K NRAEL V ES tv E F PELD E SQGEILLS - W I ----- 285
Cdd:PTZ00432 308 YFY G PNDVT E R LE F V D N YLTKH P ktg QLSH T AYREDADENLLYEEY K DKPKH V KK -- K F SSHS E EEENLMSV s W L lnpkh 385
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 286 ------ GE S YLSFR D D LA VSM L LDYFTESALAPFT K Q L ve ID DP L ANST -- DYWT D D F MRT I INL G IH G V pte K L T ET K N 357
Cdd:PTZ00432 386 ngskdy DK S LIDPV D Y LA LLV L NYLLLGTPESVLY K A L -- ID SG L GKKV vg SGLD D Y F KQS I FSI G LK G I --- K E T NE K R 460
410 420
....*....|....*....|...
gi 366992167 358 K VLDILKNHEID L KRIRQ VV DN G 380
Cdd:PTZ00432 461 K DKVHYTFEKVV L NALTK VV TE G 483
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
193-365
4.87e-16
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 77.05
E-value: 4.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 193 D LT N E EIKE F H K AN YS S DN LC L I I C G N V PES ELL EIVQNWDNS LP DKDLTRKKR P fldsvdfqi P KNR A E L VEST V EF P E 272
Cdd:pfam05193 1 S LT R E DLRD F Y K KH YS P DN MV L V I V G D V DHE ELL DLAEKYFGD LP ASPKGKPRP P --------- P LEP A K L KGRE V VV P K 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 273 L DE S Q GEIL L SWI G ESYLSFR D D LA VSM L LDYFTESALAPFTKQ L V E i DDP LA N S TDYWT D DF - MRTIINLGI h G V PT E K 351
Cdd:pfam05193 72 K DE P Q AHLA L AFP G PPLNNDE D S LA LDV L NELLGGGMSSRLFQE L R E - KEG LA Y S VSSFN D SY s DSGLFGIYA - T V DP E N 149
170
....*....|....
gi 366992167 352 LT E TKNKV L DI L KN 365
Cdd:pfam05193 150 VD E VIELI L EE L EK 163
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
738-992
4.95e-10
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 63.02
E-value: 4.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 738 L E TM R TQLRENF -- N KFHILIF GD ISKIST nvytpw QN LVE Q - FG VI PA -- NYEVKI P PA P RP lnsisslcqk PAE R AYI 812
Cdd:COG0612 181 R E DL R AFYKRYY rp N NAVLVVV GD VDPEEV ------ LA LVE K y FG DL PA gp APPRPD P AE P PQ ---------- TGP R RVV 244
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 813 ITT P ASDS A YMTTLTSI P fdl DYN D SK Y P A VSLAS E Y L Q cvegpfwk G IRG S ---------- GLAY GANMIKMTEINSWG 882
Cdd:COG0612 245 VDD P DAEQ A HILLGYPG P --- ARD D PD Y Y A LDVLN E I L G -------- G GFS S rlfqelrekk GLAY SVGSSFSPYRDAGL 313
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 883 F N IY R GT --- DIIKCYQ A GKQIV E DY A N gi E KFDPQLIQG A ---- L N S IINR L AT ve N GYF A AGIAK Y vdd F LY KRGPNF 955
Cdd:COG0612 314 F T IY A GT apd KLEEALA A ILEEL E RL A K -- E GVTEEELER A knql L G S LALS L ES -- N SGL A SQLGR Y --- E LY GGDLDY 386
250 260 270
....*....|....*....|....*....|....*..
gi 366992167 956 NKKF LER LAK VTA D D M Q K V MKE Y lvnl FN P EKSI V FI 992
Cdd:COG0612 387 LEEY LER IEA VTA E D V Q A V ARK Y ---- LD P DNLV V VV 419
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
33-160
3.52e-07
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 50.77
E-value: 3.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 33 HVDHK S SPLV qg YFAV G T -- E CP N DS G VP H T LEH LI F M G S K QH P YKG L LDTVGN L CM S S t NA W T ATDQ TVY TL t SAGWKG 110
Cdd:pfam00675 8 PPADT S TVGL -- WIDA G S ry E PD N NN G LA H F LEH MA F K G T K KY P SNE L EEELEK L GG S L - NA F T SREN TVY YA - EVLNDD 83
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 366992167 111 FS K ILPAYLNHILF P TL T DDACTT E vyhvdpedlsd KG VV FS E M EA IE S Q 160
Cdd:pfam00675 84 LP K AVDRLADFFRN P LF T ESEIER E ----------- RL VV LY E V EA VD S E 122
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
57-245
4.94e-07
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 54.09
E-value: 4.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 57 G VP H T LEH LI F M G S K QH P ykglld TV G NL c MS ------- S T NA W TAT DQ T V Y tltsagwkg FSKILPAY L NHI L ------ 123
Cdd:COG1025 86 G LA H F LEH ML F L G T K KY P ------ EP G EY - QE fiskhgg S H NA S TAT ER T N Y --------- YFEVENDA L EEA L drfadf 149
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366992167 124 -- F P TL tddact TEV Y h VD P E dlsd KGV V FS E MEAIE S QSWF - VTMLE K QR L M ---- F P R G S GYRS ET ggltnn L R D LTN 196
Cdd:COG1025 150 fa A P LF ------ DPE Y - VD R E ---- RNA V NA E YTLKR S DDGR r IYQVH K ET L N pahp F S R F S VGNL ET ------ L S D KPG 212
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 366992167 197 ---- E E IKE F HKAN YS SDNLC L IICG N VPES EL LEIVQNWDNSL P DKD L TRKK 245
Cdd:COG1025 213 sklr D E LLA F YQRY YS ANLMK L VLYS N QSLD EL EKLARQTFGAI P NRN L SVPP 265
PRK15101
PRK15101 protease3; Provisional
48-103
4.55e-04
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 44.20
E-value: 4.55e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 366992167 48 VG T - E C P NDS - G VP H T LEH LIF MGSK QH P YKGL L DTVGNLCMS S T NA W TA TDQ T VYT L 103
Cdd:PRK15101 74 VG S l E D P DAQ q G LA H Y LEH MVL MGSK KY P QPDS L AEFLKKHGG S H NA S TA SYR T AFY L 131
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
