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Conserved domains on  [gi|367048133|ref|XP_003654446|]
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uncharacterized protein THITE_160239 [Thermothielavioides terrestris NRRL 8126]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
44-459 8.49e-92

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17327:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 406  Bit Score: 285.30  E-value: 8.49e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  44 KTDTRILPILSLLFLCSFLDRTNVGNAKIIGLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAV 123
Cdd:cd17327    1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 124 WGLVTTCLGFVRAFASFFAVRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGPRG 203
Cdd:cd17327   81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 204 GLEGWRWIFIIEGLITVVAAALAYLLLPTSIATASYLTQEERDFAVLRLQggARSTSSErfnpvlerEEKFKWSEVRRGV 283
Cdd:cd17327  161 GLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLR--ANQTGKG--------DQKFKWKQIKEAF 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 284 FNLQVWLSATAYFGILSGLYSFGLFLPTIINDLkiTSNANETQLWSVIPYA---VATPITAFLSDRLNLRGVVMLCTLPL 360
Cdd:cd17327  231 KDPRTWLLFLFFFCSQITNNGISNFLPLILKSL--GFYSLQTNLLSVPIGAlgaVSLLIAALLSDRFKKRGLFAIFACVL 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 361 AIAGYAAIANVASATVRFGMTCLMATGMYASVPCVLVWNSNNSAGHYKRATTSALQLAIANCGGFVATFVYPNSDGPLYH 440
Cdd:cd17327  309 ALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYI 388
                        410
                 ....*....|....*....
gi 367048133 441 KGHTIilwLLVYAWFAILA 459
Cdd:cd17327  389 PGNIA---LLVCACVSIVL 404
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
44-459 8.49e-92

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 285.30  E-value: 8.49e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  44 KTDTRILPILSLLFLCSFLDRTNVGNAKIIGLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAV 123
Cdd:cd17327    1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 124 WGLVTTCLGFVRAFASFFAVRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGPRG 203
Cdd:cd17327   81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 204 GLEGWRWIFIIEGLITVVAAALAYLLLPTSIATASYLTQEERDFAVLRLQggARSTSSErfnpvlerEEKFKWSEVRRGV 283
Cdd:cd17327  161 GLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLR--ANQTGKG--------DQKFKWKQIKEAF 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 284 FNLQVWLSATAYFGILSGLYSFGLFLPTIINDLkiTSNANETQLWSVIPYA---VATPITAFLSDRLNLRGVVMLCTLPL 360
Cdd:cd17327  231 KDPRTWLLFLFFFCSQITNNGISNFLPLILKSL--GFYSLQTNLLSVPIGAlgaVSLLIAALLSDRFKKRGLFAIFACVL 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 361 AIAGYAAIANVASATVRFGMTCLMATGMYASVPCVLVWNSNNSAGHYKRATTSALQLAIANCGGFVATFVYPNSDGPLYH 440
Cdd:cd17327  309 ALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYI 388
                        410
                 ....*....|....*....
gi 367048133 441 KGHTIilwLLVYAWFAILA 459
Cdd:cd17327  389 PGNIA---LLVCACVSIVL 404
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
63-427 4.08e-30

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 121.29  E-value: 4.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133   63 DRTNVGNAKIIgLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFA 142
Cdd:TIGR00893   9 DRANLSFAAPM-LQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  143 VRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAigprggLEGWRWIFIIEGLITVVA 222
Cdd:TIGR00893  88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HFSWQWAFIIEGVLGIIW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  223 AALAYLLLPTSIATASYLTQEERdfavLRLQGGARSTSSERFNPvlereeKFKWSEVRRGVFNLQVWLSATAYFGILSGL 302
Cdd:TIGR00893 162 GVLWLKFIPDPPQKAKWLTEEEK----YIVVGGLLAEQQGKGPS------TPKKYQIKELLKDRRVWGLALGQFLVNIGL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  303 YSFGLFLPTIINDLKItSNANETQLWSVIPYAVA---TPITAFLSDRLNLRGVVMLCTLPLAIAGYAAIANVASATVRFG 379
Cdd:TIGR00893 232 GFFLTWFPTYLVQERG-LSILEAGFMASLPGIVGfigMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVN 310
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 367048133  380 MT----CLMATGMYASVPCVLVW-NSNNSAGHYKRATTSALQLAIANCGGFVA 427
Cdd:TIGR00893 311 IPyaalALVALGFFGLGAGAIGWaLISDNAPGNIAGLTGGLINSLGNLGGIVG 363
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
48-430 3.61e-24

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 103.41  E-value: 3.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  48 RILPILSLLFLCSFLDRTNVGNAKIIgLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLV 127
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 128 TTCLGFVRAFASFFAVRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGprggleG 207
Cdd:COG2271   89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF------G 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 208 WRWIFIIEGLITVVaaalaylllptsiatasyltqeerdFAVlrlqggarstsserfnpvlereekfkwsevrrgvfnLQ 287
Cdd:COG2271  163 WRAAFLILGLPGLL-------------------------LAL------------------------------------LR 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 288 VWLSATAYFGILSGLYSFGLFLPTIINDLKITSNAnETQLWSVIPY---AVATPITAFLSDRLNLRG-VVMLCTLPLAIA 363
Cdd:COG2271  182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA-QAGLLLSLPFlagIVGSLLGGWLSDRLGRRRkLVLAIGLLLAAL 260
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 367048133 364 GYAAIANVASATVRFGMTCLMATGMYASVPCVLVWNSNNSAGHYkRATTSALQLAIANCGGFVATFV 430
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPLL 326
MFS_1 pfam07690
Major Facilitator Superfamily;
63-428 1.09e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.07  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133   63 DRTNVGNAKIIGLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFA 142
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  143 VRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGprggleGWRWIFIIEGLITVVa 222
Cdd:pfam07690  91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF------GWRAAFLILAILSLL- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  223 aalaylllptsiatasyltqeerdFAVLRLQGGARSTSSerfNPVLEREEKFKWSEVRRGVFNLQVWLSATAYFGILSGL 302
Cdd:pfam07690 164 ------------------------AAVLLLLPRPPPESK---RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  303 YSFGLFLPTIINDLKITSNANETQLW-SVIPYAVATPITAFLSDRLNLRGVVMLCTLPLAIA--GYAAIANVASATVRFG 379
Cdd:pfam07690 217 FGLLTYLPLYQEVLGLSALLAGLLLGlGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalGLLLLSLTLSSLWLLL 296
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 367048133  380 MTCLMATGMYASVPCVLVWnSNNSAGHYKRATTSALQLAIANCGGFVAT 428
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNAL-VSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
44-459 8.49e-92

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 285.30  E-value: 8.49e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  44 KTDTRILPILSLLFLCSFLDRTNVGNAKIIGLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAV 123
Cdd:cd17327    1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 124 WGLVTTCLGFVRAFASFFAVRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGPRG 203
Cdd:cd17327   81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 204 GLEGWRWIFIIEGLITVVAAALAYLLLPTSIATASYLTQEERDFAVLRLQggARSTSSErfnpvlerEEKFKWSEVRRGV 283
Cdd:cd17327  161 GLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLR--ANQTGKG--------DQKFKWKQIKEAF 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 284 FNLQVWLSATAYFGILSGLYSFGLFLPTIINDLkiTSNANETQLWSVIPYA---VATPITAFLSDRLNLRGVVMLCTLPL 360
Cdd:cd17327  231 KDPRTWLLFLFFFCSQITNNGISNFLPLILKSL--GFYSLQTNLLSVPIGAlgaVSLLIAALLSDRFKKRGLFAIFACVL 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 361 AIAGYAAIANVASATVRFGMTCLMATGMYASVPCVLVWNSNNSAGHYKRATTSALQLAIANCGGFVATFVYPNSDGPLYH 440
Cdd:cd17327  309 ALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYI 388
                        410
                 ....*....|....*....
gi 367048133 441 KGHTIilwLLVYAWFAILA 459
Cdd:cd17327  389 PGNIA---LLVCACVSIVL 404
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
63-427 4.08e-30

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 121.29  E-value: 4.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133   63 DRTNVGNAKIIgLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFA 142
Cdd:TIGR00893   9 DRANLSFAAPM-LQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  143 VRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAigprggLEGWRWIFIIEGLITVVA 222
Cdd:TIGR00893  88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HFSWQWAFIIEGVLGIIW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  223 AALAYLLLPTSIATASYLTQEERdfavLRLQGGARSTSSERFNPvlereeKFKWSEVRRGVFNLQVWLSATAYFGILSGL 302
Cdd:TIGR00893 162 GVLWLKFIPDPPQKAKWLTEEEK----YIVVGGLLAEQQGKGPS------TPKKYQIKELLKDRRVWGLALGQFLVNIGL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  303 YSFGLFLPTIINDLKItSNANETQLWSVIPYAVA---TPITAFLSDRLNLRGVVMLCTLPLAIAGYAAIANVASATVRFG 379
Cdd:TIGR00893 232 GFFLTWFPTYLVQERG-LSILEAGFMASLPGIVGfigMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVN 310
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 367048133  380 MT----CLMATGMYASVPCVLVW-NSNNSAGHYKRATTSALQLAIANCGGFVA 427
Cdd:TIGR00893 311 IPyaalALVALGFFGLGAGAIGWaLISDNAPGNIAGLTGGLINSLGNLGGIVG 363
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
63-463 4.83e-28

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 114.59  E-value: 4.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  63 DRTNVGNAKIIgLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFA 142
Cdd:cd17319   18 DRVNISVAAPT-IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 143 VRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLarglsaIGPRGGLEGWRWIFIIEGLITVVA 222
Cdd:cd17319   97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPL------SGWLLLLFGWRWAFIIEGLLGLLL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 223 AALAylllptsiatasyltqeerdFAVLRlqggarstsserfnpvlereekfkwsevrrgvfnlQVWLSATAYFGILSGL 302
Cdd:cd17319  171 AVLW--------------------WFYLR-----------------------------------QVWGLALGYFGINYAL 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 303 YSFGLFLPTIINDLKITSNAnETQLWSVIPY---AVATPITAFLSDRLNL---RGVVMLCTLpLAIAGYAAIANVASATV 376
Cdd:cd17319  196 YGLLTWLPTYLKQARGFSLK-QVGLLAAIPFlagAIGMILGGRLSDRLLRgarRLVIIIGLL-LAAVGLLLAYLTTSPVV 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 377 RFGMTCLMATGMYASVPCVLVWnsnnsAGHYKRATTSALQLAIANCGGFVATFVYPNSDGPLYHKGHTIILWLLVYAWFA 456
Cdd:cd17319  274 AVILLSLAGFGIGAASPVFWSL-----PADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVA 348

                 ....*..
gi 367048133 457 ILANVLW 463
Cdd:cd17319  349 LLAALLV 355
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
48-430 3.61e-24

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 103.41  E-value: 3.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  48 RILPILSLLFLCSFLDRTNVGNAKIIgLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLV 127
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 128 TTCLGFVRAFASFFAVRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGprggleG 207
Cdd:COG2271   89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF------G 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 208 WRWIFIIEGLITVVaaalaylllptsiatasyltqeerdFAVlrlqggarstsserfnpvlereekfkwsevrrgvfnLQ 287
Cdd:COG2271  163 WRAAFLILGLPGLL-------------------------LAL------------------------------------LR 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 288 VWLSATAYFGILSGLYSFGLFLPTIINDLKITSNAnETQLWSVIPY---AVATPITAFLSDRLNLRG-VVMLCTLPLAIA 363
Cdd:COG2271  182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA-QAGLLLSLPFlagIVGSLLGGWLSDRLGRRRkLVLAIGLLLAAL 260
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 367048133 364 GYAAIANVASATVRFGMTCLMATGMYASVPCVLVWNSNNSAGHYkRATTSALQLAIANCGGFVATFV 430
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPLL 326
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
72-430 2.52e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.47  E-value: 2.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  72 IIGLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFAVRALLGLAE 151
Cdd:cd06174   19 LPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 152 GGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIgprgGLEGWRWIFIIEGLITVVaaalaylllp 231
Cdd:cd06174   99 GLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS----LGFGWRAVFLIAAALALL---------- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 232 tsIATASYLTQEERDFAVLRlqggarstsserfnPVLEREEKFKWSEVRRGVFNLQVWLSATAYFGILSGLYSFGLFLPT 311
Cdd:cd06174  165 --AAILLLLVVPDPPESARA--------------KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 312 IINDLKITSNANETQLWSV--IPYAVATPITAFLSDRLNLRGVVMLCTLPLAIAGYAAIANVASATVRFGMTCLMATGMY 389
Cdd:cd06174  229 FLLDLGGLSVAVAGLLLSLfgLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 367048133 390 ASVPCVLVWNSNNsAGHYKRATTSALQLAIANCGGFVATFV 430
Cdd:cd06174  309 GLLPLSFALIAEL-FPPEIRGTAFGLLNTFGFLGGAIGPLL 348
MFS_1 pfam07690
Major Facilitator Superfamily;
63-428 1.09e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.07  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133   63 DRTNVGNAKIIGLEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFA 142
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  143 VRALLGLAEGGLLPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGprggleGWRWIFIIEGLITVVa 222
Cdd:pfam07690  91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF------GWRAAFLILAILSLL- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  223 aalaylllptsiatasyltqeerdFAVLRLQGGARSTSSerfNPVLEREEKFKWSEVRRGVFNLQVWLSATAYFGILSGL 302
Cdd:pfam07690 164 ------------------------AAVLLLLPRPPPESK---RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  303 YSFGLFLPTIINDLKITSNANETQLW-SVIPYAVATPITAFLSDRLNLRGVVMLCTLPLAIA--GYAAIANVASATVRFG 379
Cdd:pfam07690 217 FGLLTYLPLYQEVLGLSALLAGLLLGlGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalGLLLLSLTLSSLWLLL 296
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 367048133  380 MTCLMATGMYASVPCVLVWnSNNSAGHYKRATTSALQLAIANCGGFVAT 428
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNAL-VSDLAPKEERGTASGLYNTAGSLGGALGP 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
75-471 1.94e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 65.67  E-value: 1.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  75 LEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFAVRALLGLAEGGL 154
Cdd:COG2223   31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 155 LPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGprggleGWRWIFIIEGLITVVaaalaylllptsI 234
Cdd:COG2223  111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------GWRNAFLILGILLLV------------V 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 235 ATASYLTQEERDfavlrlqggarstsserfnPVLEREEKFKWSEVRRGVFNLQVWLSATAYFGILSGLYSFGLFLPTIIN 314
Cdd:COG2223  173 AVLAWLFLRDPP-------------------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 315 DLKITSNANETQLWSVIPY--AVATPITAFLSDRLNLRGVVMLCTLPLAIAGYAAIANVASATVRFGMTCLMATGMYASV 392
Cdd:COG2223  234 DQFGLSAATAGLLAALFALlgALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGN 313
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 367048133 393 PCVLVWNSNNSAGHYkRATTSALQLAIANCGGFVATFVYpnsdGPLYHKGHTIILWLLVYAWFAILANVLWCFKINKDK 471
Cdd:COG2223  314 GAVFALVPDIFPTKN-AGAVYGLVGAAGGLGGFLGPLLF----GALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
75-427 3.50e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.61  E-value: 3.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  75 LEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFAVRALLGLAEGGL 154
Cdd:COG2814   36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAL 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 155 LPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGprggleGWRWIFIIEGLITVVaaalaylllptSI 234
Cdd:COG2814  116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF------GWRWVFLVNAVLALL-----------AL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 235 ATASYLTQEERDFAVLRLQGGARSTSSERfnpvlereekfkwsevrrgvfnlQVWLSATAYFGILSGLYSFGLFLPTIIN 314
Cdd:COG2814  179 LLLLRLLPESRPAARARLRGSLRELLRRP-----------------------RLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 315 DLKITSNANETQLWSV--IPYAVATPITAFLSDRLNLRGVVMLCTLpLAIAGYAAIANVASATVRFGMTCLMATGMYASV 392
Cdd:COG2814  236 EVLGLSASAAGLLLALfgLGGVLGALLAGRLADRFGRRRLLLIGLL-LLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 367048133 393 PCVLVWNSNNSAGHYkRATTSALQLAIANCGGFVA 427
Cdd:COG2814  315 PLLQALVAELAPPEA-RGRASGLYNSAFFLGGPLA 348
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
75-427 1.27e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 63.16  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133   75 LEEDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFAVRALLGLAEGGL 154
Cdd:TIGR00881  21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  155 LPGIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIgprggLEGWRWIFIIEGLITVVAAALAYLllptsi 234
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAE-----LYSWHWVFIVPGIIAIIVSLICFL------ 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  235 atasyLTQEERDFAVLRLQGGARSTSSERFNPVLEREEKFKWSEVRRGVFNLQVWLSATAYFGILSGLYSFGLFLPTIIN 314
Cdd:TIGR00881 170 -----LLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLT 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  315 DLKITSNANETQLWSVIPYA--VATPITAFLSDRL--NLRGVVMLCTLPLAIAGYAAIANVASATVRFGMTCLMATGMYA 390
Cdd:TIGR00881 245 QEKGFSKEKASWAFTLYELGglVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLV 324
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 367048133  391 SVPCVLVWNSNNSAGHYKRA-TTSALQLAIANCGGFVA 427
Cdd:TIGR00881 325 YGPQMLIGVIASELAPKKAAgTAAGFVGFFAYLGGILA 362
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
77-430 2.80e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.39  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  77 EDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFAVRALLGLAEGGLLP 156
Cdd:cd17324   27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 157 GIVLYLSGLYTRREMAVRIGMFYTAASLSGAFGGLLARGLSAIGprggleGWRWIFIIEGLITVVAAALAYLLLPtsiat 236
Cdd:cd17324  107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL------GWRAAFLAIAVLALLAALLLWRLLP----- 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 237 asyltqeerdfavlrlqggaRSTSSERFNPVLEREEKFKWSevrrgvfNLQVWLSATAYFGILSGLYSFGLFLPTIINDL 316
Cdd:cd17324  176 --------------------SLPPKKPGSLGLLSSLLLLLR-------NPRLRLAYLITFLLFGGFFALYTYLAPFLTDV 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 317 KITSNANETQLWSV--IPYAVATPITAFLSDRLNLRGVVMLCTLpLAIAGYAAIANVASATVRFGMTCLMATGMYASVPC 394
Cdd:cd17324  229 PGFSSSAIIGLLLLfgVAGVVGSPLAGRLADRGGRRALLIALLL-LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSA 307
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 367048133 395 VLVWNSNNSAGHykRATTSALQLAIANCGGFVATFV 430
Cdd:cd17324  308 LQTRVLRLAPEA--RGLASSLYLAAYNLGGALGAAL 341
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
77-363 1.16e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133  77 EDLGISNLQYNQGLAVFYATYIASELPSNLVLKRLSPTLWLPLLTAVWGLVTTCLGFVRAFASFFAVRALLGLAEGGLLP 156
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 157 GIVLYLSGLYTRREMAVRIGMFYTAASLSGA----FGGLLArglsaigprgGLEGWRWIFIIEGLITVVAAalaylllpt 232
Cdd:cd17325  104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLigplLGGLLA----------DALGYRAPFLVCAALALLAL--------- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 233 siatasyltqeerdFAVLRLQGGARSTSSERFNPVLEREEKFKWSEVRRGVFnlqvwlsaTAYFGILSGLYSFGLFLPTI 312
Cdd:cd17325  165 --------------VLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLL--------ALFLAIFVLAFAFGALEPFL 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 367048133 313 INDLKITSNANETQ-----LWSVIPYAVATPITAFLSDRLNLRGVVMLCTLPLAIA 363
Cdd:cd17325  223 PLYAAELGGLSPAQigllfGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
288-463 4.56e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.12  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 288 VWLSATAYFGILSGLYSFGLFLPTIINDLKITSNANETQ--LWSVIPYAVATPITAFLSDRLNLRGVVMLCTLPLAIAGY 365
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLylLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367048133 366 A-AIANVASATVRFGMTCLMA---TGMYASVPCVLvwnsnnsAGHYK---RATTSALQLAIANCGGFVATFVYPnsdgPL 438
Cdd:cd17316  259 PlFYLLSGSPTLLLLLLFILSffvGGVWGALYAYL-------AELFPtevRATGVGLSYNLGRLGGGGAPPLIA----LL 327
                        170       180
                 ....*....|....*....|....*
gi 367048133 439 YHKGHTIILWLLVYAWFAILANVLW 463
Cdd:cd17316  328 LASTGGTGVPALILALLAIVALIVA 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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