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Conserved domains on  [gi|367040337|ref|XP_003650549|]
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uncharacterized protein THITE_2085717 [Thermothielavioides terrestris NRRL 8126]

Protein Classification

DOPA 4,5-dioxygenase family protein( domain architecture ID 10556249)

DOPA (dihydroxyphenylalanine) 4,5-dioxygenase family protein similar to Amanita muscaria DOPA 4,5-dioxygenase, an extradiol dioxygenase that opens up the cyclic ring of DOPA between carbons 4 and 5 to produce an unstable seco-DOPA that rearranges non-enzymatically to betalamic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DOPA_dioxygen pfam08883
Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4, ...
 61-170 6.45e-64

Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.


:

Pssm-ID: 430285  Cd Length: 105  Bit Score: 192.35  E-value: 6.45e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367040337   61 FDVHIYYFQSNPAQTRYARALWERIRREFPELRIYAFWDRPIGPHPVAMFEVNlLTPAQFGAFVPWLAVWRGPLSVLVHP 140
Cdd:pfam08883   1 YHAHIYFFQNDPAEVEYARALRERIRREFPELRVGRFHDKPIGPHPVAMFEVN-FTPEQFGAVVPWLALNRGPLSVLIHP 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 367040337  141 NTtepdpGRELRNHTQRAIWMGERLPLDLD 170
Cdd:pfam08883  80 NT-----GDDLRDHTDRALWLGEPLPLDLS 104
 
Name Accession Description Interval E-value
DOPA_dioxygen pfam08883
Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4, ...
 61-170 6.45e-64

Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.


Pssm-ID: 430285  Cd Length: 105  Bit Score: 192.35  E-value: 6.45e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367040337   61 FDVHIYYFQSNPAQTRYARALWERIRREFPELRIYAFWDRPIGPHPVAMFEVNlLTPAQFGAFVPWLAVWRGPLSVLVHP 140
Cdd:pfam08883   1 YHAHIYFFQNDPAEVEYARALRERIRREFPELRVGRFHDKPIGPHPVAMFEVN-FTPEQFGAVVPWLALNRGPLSVLIHP 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 367040337  141 NTtepdpGRELRNHTQRAIWMGERLPLDLD 170
Cdd:pfam08883  80 NT-----GDDLRDHTDRALWLGEPLPLDLS 104
DodA COG3805
Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and ...
 51-173 5.22e-32

Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443018  Cd Length: 114  Bit Score: 111.53  E-value: 5.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367040337  51 DPLDNGRRGAFDVHIYYfqsNPAQTRYARALWERIRREFPeLRIYAFWDRPIGPHPVAMFEVNLlTPAQFGAFVPWLAVW 130
Cdd:COG3805    2 TPRPTNDIAGYHAHVYF---DEASREAAAALREEAGERFG-VRVGRWHEKPVGPHPKWSYQLAF-LPEQFDEVVPWLMLN 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 367040337 131 RGPLSVLVHPNTtepdpGRELRNHTQRAIWMGERLPLDLDRLR 173
Cdd:COG3805   77 RGGLDILVHPLT-----GDDLADHTDHALWLGESLELNLSRLR 114
 
Name Accession Description Interval E-value
DOPA_dioxygen pfam08883
Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4, ...
 61-170 6.45e-64

Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.


Pssm-ID: 430285  Cd Length: 105  Bit Score: 192.35  E-value: 6.45e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367040337   61 FDVHIYYFQSNPAQTRYARALWERIRREFPELRIYAFWDRPIGPHPVAMFEVNlLTPAQFGAFVPWLAVWRGPLSVLVHP 140
Cdd:pfam08883   1 YHAHIYFFQNDPAEVEYARALRERIRREFPELRVGRFHDKPIGPHPVAMFEVN-FTPEQFGAVVPWLALNRGPLSVLIHP 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 367040337  141 NTtepdpGRELRNHTQRAIWMGERLPLDLD 170
Cdd:pfam08883  80 NT-----GDDLRDHTDRALWLGEPLPLDLS 104
DodA COG3805
Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and ...
 51-173 5.22e-32

Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443018  Cd Length: 114  Bit Score: 111.53  E-value: 5.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367040337  51 DPLDNGRRGAFDVHIYYfqsNPAQTRYARALWERIRREFPeLRIYAFWDRPIGPHPVAMFEVNLlTPAQFGAFVPWLAVW 130
Cdd:COG3805    2 TPRPTNDIAGYHAHVYF---DEASREAAAALREEAGERFG-VRVGRWHEKPVGPHPKWSYQLAF-LPEQFDEVVPWLMLN 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 367040337 131 RGPLSVLVHPNTtepdpGRELRNHTQRAIWMGERLPLDLDRLR 173
Cdd:COG3805   77 RGGLDILVHPLT-----GDDLADHTDHALWLGESLELNLSRLR 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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