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Conserved domains on  [gi|357121612|ref|XP_003562512|]
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angio-associated migratory cell protein [Brachypodium distachyon]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-392 5.05e-79

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 249.06  E-value: 5.05e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  59 AFHGHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTAT 138
Cdd:COG2319   73 TLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 139 QTLQGTLEGSSGsGFEWLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRI 218
Cdd:COG2319  152 GKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 219 WDPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGS 298
Cdd:COG2319  231 WDLATGKLLRTLTGH---SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 299 IDKTLIIWDLA-HQSIRSTCEHDEGVTCLAWLGSSRYVASGCIDGVVRIWDSLSGELARTFSGHRDVVQSLTVSADGNSI 377
Cdd:COG2319  308 DDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                        330
                 ....*....|....*
gi 357121612 378 VSASSDRTARVFDIS 392
Cdd:COG2319  388 ASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-392 5.05e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 249.06  E-value: 5.05e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  59 AFHGHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTAT 138
Cdd:COG2319   73 TLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 139 QTLQGTLEGSSGsGFEWLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRI 218
Cdd:COG2319  152 GKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 219 WDPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGS 298
Cdd:COG2319  231 WDLATGKLLRTLTGH---SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 299 IDKTLIIWDLA-HQSIRSTCEHDEGVTCLAWLGSSRYVASGCIDGVVRIWDSLSGELARTFSGHRDVVQSLTVSADGNSI 377
Cdd:COG2319  308 DDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                        330
                 ....*....|....*
gi 357121612 378 VSASSDRTARVFDIS 392
Cdd:COG2319  388 ASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-390 1.41e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 223.37  E-value: 1.41e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 100 VQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTATQTLQGTLEGSSGSGFeWLKWHPRGHLIIAGSEDCNVWMWNA 179
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVR-DVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 180 DHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIWDPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDS 259
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 260 SVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGSIDKTLIIWDLAHQSIRSTCE-HDEGVTCLAWLGSSRYVASG 338
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 357121612 339 CIDGVVRIWDSLSGELARTFSGHRDVVQSLTVSADGNSIVSASSDRTARVFD 390
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 93-309 3.33e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.19  E-value: 3.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  93 RIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTATQTLQG------TLEGSSGSGFEWLKWHPRGHLII 166
Cdd:PLN00181 469 RVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGrdihypVVELASRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 167 AGSE-DCNVWMWNADHNAFLNTFAGHSSTVTCGDF-TPDGKVICSGSDDASLRIWDPKSAQSRHVVRGHGyhtqGLTCLA 244
Cdd:PLN00181 549 ASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKA----NICCVQ 624

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 357121612 245 ITSDS-QSIVSGSMDSSVHIVNINTGQV-VGSLVGHTNSVECIGISSRYNWVATgSIDKTLIIWDLA 309
Cdd:PLN00181 625 FPSESgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDLS 690
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 238-342 2.12e-07

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 52.38  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  238 QGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGSIDKTLIIWDLAH-----QS 312
Cdd:pfam20426  83 QCFATLQTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRgrsseKR 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 357121612  313 IRST-------------------CEHDEGVTCLAWLGSSRYVASGCIDG 342
Cdd:pfam20426 163 SRNTqtefprkdhviaetpfhilCGHDDIITCLYVSVELDIVISGSKDG 211
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-135 1.34e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 357121612   100 VQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWN 135
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-392 5.05e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 249.06  E-value: 5.05e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  59 AFHGHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTAT 138
Cdd:COG2319   73 TLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 139 QTLQGTLEGSSGsGFEWLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRI 218
Cdd:COG2319  152 GKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 219 WDPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGS 298
Cdd:COG2319  231 WDLATGKLLRTLTGH---SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 299 IDKTLIIWDLA-HQSIRSTCEHDEGVTCLAWLGSSRYVASGCIDGVVRIWDSLSGELARTFSGHRDVVQSLTVSADGNSI 377
Cdd:COG2319  308 DDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                        330
                 ....*....|....*
gi 357121612 378 VSASSDRTARVFDIS 392
Cdd:COG2319  388 ASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
59-392 1.31e-72

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 232.49  E-value: 1.31e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  59 AFHGHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTAT 138
Cdd:COG2319   31 LLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 139 QTLQGTLEGSSGSGFEwLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRI 218
Cdd:COG2319  110 GLLLRTLTGHTGAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 219 WDPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGS 298
Cdd:COG2319  189 WDLATGKLLRTLTGH---TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 299 IDKTLIIWDLAHQSIRSTCE-HDEGVTCLAWLGSSRYVASGCIDGVVRIWDSLSGELARTFSGHRDVVQSLTVSADGNSI 377
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345

                        330
                 ....*....|....*
gi 357121612 378 VSASSDRTARVFDIS 392
Cdd:COG2319  346 ASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-390 1.41e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 223.37  E-value: 1.41e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 100 VQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTATQTLQGTLEGSSGSGFeWLKWHPRGHLIIAGSEDCNVWMWNA 179
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVR-DVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 180 DHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIWDPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDS 259
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 260 SVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGSIDKTLIIWDLAHQSIRSTCE-HDEGVTCLAWLGSSRYVASG 338
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 357121612 339 CIDGVVRIWDSLSGELARTFSGHRDVVQSLTVSADGNSIVSASSDRTARVFD 390
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-348 2.93e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.20  E-value: 2.93e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  62 GHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTATQTL 141
Cdd:cd00200    7 GHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 142 QGTLEGSSGSGFeWLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIWDP 221
Cdd:cd00200   86 VRTLTGHTSYVS-SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 222 KSAQSRHVVRGhgyHTQGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGSIDK 301
Cdd:cd00200  165 RTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 357121612 302 TLIIWDLAHQSIRSTCE-HDEGVTCLAWLGSSRYVASGCIDGVVRIWD 348
Cdd:cd00200  242 TIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-395 1.77e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.36  E-value: 1.77e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 187 TFAGHSSTVTCGDFTPDGKVICSGSDDASLRIWDPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDSSVHIVNI 266
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 267 NTGQVVGSLVGHTNSVECIGISSRYNWVATGSIDKTLIIWDLAHQSIRSTCE-HDEGVTCLAWLGSSRYVASGCIDGVVR 345
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 357121612 346 IWDSLSGELARTFSGHRDVVQSLTVSADGNSIVSASSDRTARVFDISMFK 395
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
114-392 1.93e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.93e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 114 AFSSDGKLVACGSMDGQINVWNTATQTLQGTLEGSSGSGFEWLkWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSS 193
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 194 TVTCGDFTPDGKVICSGSDDASLRIWDPKSAQSRHVVRGhgyHTQGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVG 273
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 274 SLVGHTNSVECIGISSRYNWVATGSIDKTLIIWDLAH-QSIRSTCEHDEGVTCLAWLGSSRYVASGCIDGVVRIWDSLSG 352
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATgKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 357121612 353 ELARTFSGHRDVVQSLTVSADGNSIVSASSDRTARVFDIS 392
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
60-268 9.81e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.31  E-value: 9.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  60 FHGHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTATQ 139
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 140 TLQGTLEGSSGsGFEWLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIW 219
Cdd:COG2319  279 ELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 357121612 220 DPKSAQSRHVVRGHgyhTQGLTCLAITSDSQSIVSGSMDSSVHIVNINT 268
Cdd:COG2319  358 DLATGELLRTLTGH---TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-263 4.09e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.41  E-value: 4.09e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  60 FHGHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTATQ 139
Cdd:cd00200   89 LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 140 TLQGTLEGSSGSGFeWLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIW 219
Cdd:cd00200  168 KCVATLTGHTGEVN-SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 357121612 220 DPKSAQSRHVVRGhgyHTQGLTCLAITSDSQSIVSGSMDSSVHI 263
Cdd:cd00200  247 DLRTGECVQTLSG---HTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-220 7.32e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 7.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  58 YAFHGHTDEVFAAACSPiDASLVVSGGKDDKGFLWRIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTA 137
Cdd:cd00200  129 TTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 138 TQTLQGTLEGSSGsGFEWLKWHPRGHLIIAGSEDCNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLR 217
Cdd:cd00200  208 TGKCLGTLRGHEN-GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                 ...
gi 357121612 218 IWD 220
Cdd:cd00200  287 IWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 93-309 3.33e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.19  E-value: 3.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  93 RIGSDVDVQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWNTATQTLQG------TLEGSSGSGFEWLKWHPRGHLII 166
Cdd:PLN00181 469 RVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGrdihypVVELASRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 167 AGSE-DCNVWMWNADHNAFLNTFAGHSSTVTCGDF-TPDGKVICSGSDDASLRIWDPKSAQSRHVVRGHGyhtqGLTCLA 244
Cdd:PLN00181 549 ASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKA----NICCVQ 624

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 357121612 245 ITSDS-QSIVSGSMDSSVHIVNINTGQV-VGSLVGHTNSVECIGISSRYNWVATgSIDKTLIIWDLA 309
Cdd:PLN00181 625 FPSESgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDLS 690
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 91-298 1.50e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  91 LWRIGSDVDVQELTGHEDTVCTVAFSS-DGKLVACGSMDGQINVWNTATQTLQGTLEGSSGSGFEWLKwHPRGHLIIAGS 169
Cdd:PLN00181 559 VWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP-SESGRSLAFGS 637

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 170 EDCNVWMWNADHNAF-LNTFAGHSSTVTCGDFTpDGKVICSGSDDASLRIWDpksaqsrhvvrghgyhtqgltcLAITsd 248
Cdd:PLN00181 638 ADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD----------------------LSMS-- 692

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 357121612 249 sqsiVSGSMDSSVHivnintgqvvgSLVGHTNSVECIGISSRYNWVATGS 298
Cdd:PLN00181 693 ----ISGINETPLH-----------SFMGHTNVKNFVGLSVSDGYIATGS 727
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 238-342 2.12e-07

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 52.38  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  238 QGLTCLAITSDSQSIVSGSMDSSVHIVNINTGQVVGSLVGHTNSVECIGISSRYNWVATGSIDKTLIIWDLAH-----QS 312
Cdd:pfam20426  83 QCFATLQTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRgrsseKR 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 357121612  313 IRST-------------------CEHDEGVTCLAWLGSSRYVASGCIDG 342
Cdd:pfam20426 163 SRNTqtefprkdhviaetpfhilCGHDDIITCLYVSVELDIVISGSKDG 211
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 305-369 2.14e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.43  E-value: 2.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 357121612  305 IWDLahqsirSTCEHDEGVTCLAWLGSSRYVASGCIDGVVRIWDSLSGELARTFSGHRDVVQSLT 369
Cdd:pfam12894  29 VWTL------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLG 87
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-135 1.34e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 357121612   100 VQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWN 135
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 191-393 1.35e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 191 HSSTVTCG-DFTPDGKVICSGSDDASLRIWDPKS----AQSRH--VVRGHGYHTQGLTCLAITSDSQsIVSGSMDSSVHI 263
Cdd:PLN00181 481 NSSNLVCAiGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypVVELASRSKLSGICWNSYIKSQ-VASSNFEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 264 VNINTGQVVGSLVGHTNSVECIGISSR-YNWVATGSIDKTLIIWDLAHQSIRSTCEHDEGVTCLAWLGSS-RYVASGCID 341
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSSAdPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESgRSLAFGSAD 639

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 357121612 342 GVVRIWDSLSGELAR-TFSGHRDVVqSLTVSADGNSIVSASSDRTARVFDISM 393
Cdd:PLN00181 640 HKVYYYDLRNPKLPLcTMIGHSKTV-SYVRFVDSSTLVSSSTDNTLKLWDLSM 691
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 185-220 1.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.50e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 357121612   185 LNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIWD 220
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
100-135 1.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 357121612  100 VQELTGHEDTVCTVAFSSDGKLVACGSMDGQINVWN 135
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
184-220 2.99e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 357121612  184 FLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIWD 220
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 268-307 1.92e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357121612   268 TGQVVGSLVGHTNSVECIGISSRYNWVATGSIDKTLIIWD 307
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
269-307 2.49e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 357121612  269 GQVVGSLVGHTNSVECIGISSRYNWVATGSIDKTLIIWD 307
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-348 3.39e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.39e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 357121612   319 HDEGVTCLAWLGSSRYVASGCIDGVVRIWD 348
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 351-390 4.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.64e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357121612   351 SGELARTFSGHRDVVQSLTVSADGNSIVSASSDRTARVFD 390
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 296-390 4.91e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 4.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 296 TGSIDKTLIIWDLAHQSIRSTCE--------HDEGVTCLAWLGSSRYV-ASGCIDGVVRIWDSLSGELARTFSGHRDVVQ 366
Cdd:PTZ00421  93 TASEDGTIMGWGIPEEGLTQNISdpivhlqgHTKKVGIVSFHPSAMNVlASAGADMVVNVWDVERGKAVEVIKCHSDQIT 172

                         90       100
                 ....*....|....*....|....
gi 357121612 367 SLTVSADGNSIVSASSDRTARVFD 390
Cdd:PTZ00421 173 SLEWNLDGSLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
311-348 4.95e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357121612  311 QSIRSTCEHDEGVTCLAWLGSSRYVASGCIDGVVRIWD 348
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
352-390 9.85e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 9.85e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 357121612  352 GELARTFSGHRDVVQSLTVSADGNSIVSASSDRTARVFD 390
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 103-223 2.44e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612 103 LTGHEDTVCTVAFS--SDGKLVAcGSMDGQINVWNTATQTLQGT-------LEGSSGS-GFewLKWHPRGHLIIAGS-ED 171
Cdd:PTZ00421  71 LLGQEGPIIDVAFNpfDPQKLFT-ASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKvGI--VSFHPSAMNVLASAgAD 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 357121612 172 CNVWMWNADHNAFLNTFAGHSSTVTCGDFTPDGKVICSGSDDASLRIWDPKS 223
Cdd:PTZ00421 148 MVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 112-178 6.63e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.33  E-value: 6.63e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 357121612  112 TVAFSSDGKLVAC---GSMDGQINVWNTATQTLQGTLEGSSGSGFEwlkWHPRGHLIIAGSE------DCNVWMWN 178
Cdd:pfam08662 105 TIFWSPFGRLVLLagfGNLAGDIEFWDVVNKKKIATAEASNATLCE---WSPDGRYFLTATTaprlrvDNGFKIWH 177
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-392 1.52e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 1.52e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 357121612 354 LARTFSGHRDVVQSLTVSADGNSIVSASSDRTARVFDIS 392
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 191-304 8.85e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 37.74  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357121612  191 HSSTVTCGDFTPDGKVICSGSDDASLRIWdpksaqsrHVVRGHGYHTQGLTCLAITSDSQSIVSgsmDSSVHIvnintgq 270
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW--------EVLRGRSSEKRSRNTQTEFPRKDHVIA---ETPFHI------- 184

                          90       100       110
                  ....*....|....*....|....*....|....
gi 357121612  271 vvgsLVGHTNSVECIGISSRYNWVATGSIDKTLI 304
Cdd:pfam20426 185 ----LCGHDDIITCLYVSVELDIVISGSKDGTCI 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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