BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  30 LTDTTLACQGGMLRAHRLVLAACSPYFERVFKEH-YGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKTATD 108
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 350405543 109 LEIRG 113
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  30 LTDTTLACQGGMLRAHRLVLAACSPYFERVFKEH-YGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKTATD 108
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 350405543 109 LEIRG 113
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543    32 DTTLACQGGMLRAHRLVLAACSPYFERVFKEH--YGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKTATDL 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*
gi 350405543   110 EIRGL 114
Cdd:smart00225  81 QIPGL 85

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 350405543  341 FSCDLCTLAFTRASHLARHRRVH 363
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  30 LTDTTLACQGGMLRAHRLVLAACSPYFERVFKEH-YGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKTATD 108
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 350405543 109 LEIRG 113
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350405543  30 LTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKTA 106
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKEssSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  24 LYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPS 101
Cdd:cd18242   15 LRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEkgKSEVELQGLTASTMEILLDFVYTETVHVTVENVQE 94

                         90
                 ....*....|..
gi 350405543 102 LIKTATDLEIRG 113
Cdd:cd18242   95 LLPAACLLQLKG 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  21 FEGLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGEQ-PILI-LKGVAVEEMECLLDFMYRGSIDVAEEH 98
Cdd:cd18240    8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETeKKVYkIPGVSPEMMELIIEYAYTRTVPITAEN 87

                         90
                 ....*....|....*.
gi 350405543  99 LPSLIKTATDLEIRGL 114
Cdd:cd18240   88 VEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  13 HLANLSGLFEGLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGEQPI--LILKGVAVEEMECLLDFMYRG 90
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSseVELKDAEPDIIELLVEFAYTA 83

                         90       100
                 ....*....|....*....|.
gi 350405543  91 SIDVAEEHLPSLIKTATDLEI 111
Cdd:cd18237   84 RISVNSNNVQSLLDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  24 LYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPS 101
Cdd:cd18235   15 LRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSEsrANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQV 94

                         90
                 ....*....|
gi 350405543 102 LIKTATDLEI 111
Cdd:cd18235   95 LLPAANLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  17 LSGLFEGlYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGEQPILILKG---------VAVEEMECLLDFM 87
Cdd:cd18327   13 LSCLNEQ-RRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGgqdvceldfVGPEALGALLEFA 91

                         90       100
                 ....*....|....*....|....
gi 350405543  88 YRGSIDVAEEHLPSLIKTATDLEI 111
Cdd:cd18327   92 YTATLTISSSNMREVLRAARLLEI 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  17 LSGLFEgLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVF----KEHYGEQpiLILKGVAVEEMECLLDFMYRGSI 92
Cdd:cd18250    9 LRGLSE-LRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFagelRESRADR--VVLHGVSAEILGLLLDFSYTGRV 85

                         90
                 ....*....|....
gi 350405543  93 DVAEEHLPSLIKTA 106
Cdd:cd18250   86 TVTQDNVEALLRAA 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  17 LSGLFEGlYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYG--EQPILILKGVAVEEMECLLDFMYRGSIDV 94
Cdd:cd18198   13 LSGLNEQ-RTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVvdQQNVYEIDFVSPEALTALLEFAYTATLTV 91

                         90
                 ....*....|....*..
gi 350405543  95 AEEHLPSLIKTATDLEI 111
Cdd:cd18198   92 STANVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  24 LYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPS 101
Cdd:cd18268   17 LRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFREssQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLP 96

                 ....*....
gi 350405543 102 LIKTATDLE 110
Cdd:cd18268   97 LMEAASMLQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  10 WNNHLANLSGLfeglYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVF--KEHYGEQPILILKGVAVEEMECLLDFM 87
Cdd:cd18306    2 PESVLAKLNAL----RKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFssDSDGESILTVKLDGLDPDAVEVLVNYA 77

                         90       100
                 ....*....|....*....|....*
gi 350405543  88 YRGSIDVAEEHLPSLIKTATDLEIR 112
Cdd:cd18306   78 YTSRLEVPADLVKSVYSAAKKLKMD 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  13 HLANLSGLFEGLYKSGSLTDTTLACQGGML-RAHRLVLAACSPYFERVFKEHYGEQP--ILILKGVAVEEMECLLDFMYR 89
Cdd:cd18252    4 HPADFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSnnVIKLSGIDHDILEALVNYVYT 83

                         90       100
                 ....*....|....*....|.
gi 350405543  90 GSIDVAEEHLPSLIKTATDLE 110
Cdd:cd18252   84 SQICITERNVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  30 LTDTTLACQGGMLRAHRLVLAACSPYFERVFKEhYGEQPILILKGVAVEEMECLLDFMYRGSIDV-AEEHLPSLIKTATD 108
Cdd:cd18221   18 FTDITLIVDGHQFKAHKAVLAACSQFFYKFFQD-FTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVqGEEEANDVWKAAEY 96

                         90
                 ....*....|....*....
gi 350405543 109 LE----IRGLsgDQRNQEN 123
Cdd:cd18221   97 LQmqeaIKAL--EFRNKES 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  30 LTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGEQP----ILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKT 105
Cdd:cd18245   14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQA 93

                 ....*....
gi 350405543 106 A-----TDL 109
Cdd:cd18245   94 AdlllmTDL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  12 NHLANLSGLFEGLYKSGSLTDTTLACQGGMLRA--------HRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEME 81
Cdd:cd18273    8 AHARALLAQLKSFYDARLLTDVTIEVNGPGSGPgsgrlfpcNRNVLAAASPYFKSMFTGGLYEskQETVTIHDVDSESMA 87

                         90       100       110
                 ....*....|....*....|....*....|
gi 350405543  82 CLLDFMYRGSIDVAEEHLPSLIKTATDLEI 111
Cdd:cd18273   88 LIIDYCYTGRVTLSEANVQRLYAAANMLQL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  28 GSLTDTTLACQGGMLRAHRLVLAACSPYFERvfKEHYGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKTAT 107
Cdd:cd18229   16 GHFCDVTVRIHDASLRAHRCVLAAGSPFFHD--KLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVVAQSEALQILTAAS 93

                 ....*
gi 350405543 108 DLEIR 112
Cdd:cd18229   94 ILQIK 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 350405543  17 LSGLfEGLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEMECLLDFMY 88
Cdd:cd18255    6 LQGL-NALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMREssQDEIELKGVSAKGLKHILDFAY 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  17 LSGLFEgLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEMECLLDFMYRGSIDV 94
Cdd:cd18257    6 LQGLNL-LRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEkeNSEVEFQCIDETALQAIVEYAYTGTVFI 84

                         90
                 ....*....|....*...
gi 350405543  95 AEEHLPSLIKTATDLEIR 112
Cdd:cd18257   85 SQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  20 LFEGLYK---SGSLTDTTLACQGGMLRAHRLVLAACSPYFERVF---KEHYGEQPILILKGVAVEEMECLLDFMYRGSID 93
Cdd:cd18293    2 AFLQLHRqqnSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLssePPPAGQKVVLELQGLKAHTLLKLVDFLYTSELE 81

                         90       100
                 ....*....|....*....|...
gi 350405543  94 VAEEHLPSLIKTATDLEIRGLSG 116
Cdd:cd18293   82 VSSEEAQDVLAAARRLQISELES 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  18 SGLFEGLYK---SGSLTDTTLACQGGMLRAHRLVLAACSPYFERvfKEHYGEQPILILKGV-AVEEMECLLDFMYRGSID 93
Cdd:cd18200    3 SALLETLNKhrlEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHD--KLLLNDTNCLVLPSViEAAAFENLLQLIYSGRLT 80

                         90
                 ....*....|....*...
gi 350405543  94 VAEEHLPSLIKTATDLEI 111
Cdd:cd18200   81 LCMDALPSHLLVASGLQM 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  17 LSGLFEGlYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEH--YGEQPILILKGVAVEEMECLLDFMYRGSIDV 94
Cdd:cd18326   13 LSSLNEQ-RTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGavVDQQNVYEIDFVSAEALTALLDFAYTATLTV 91

                         90       100
                 ....*....|....*....|.
gi 350405543  95 AEEHLPSLIKTATDLEIRGLS 115
Cdd:cd18326   92 STSNVGDILSAARLLEIPAVS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  30 LTDTTLACQGGMLRAHRLVLAACSPYF-ERVFKEHYGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIKTATD 108
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFlSRVVGQTDGDLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                 ....*.
gi 350405543 109 LEIRGL 114
Cdd:cd18955   81 LGVHNI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  22 EGLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHyGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPS 101
Cdd:cd18218   10 ARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNP-NPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELRP 88

                         90
                 ....*....|...
gi 350405543 102 LIKTATDLEIRGL 114
Cdd:cd18218   89 LLEAARALEVESL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  13 HLANLSGLFEGLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE--QPILILKGVAVEEMECLLDFMYRG 90
Cdd:cd18244   13 HDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRErdQDKIHLKGLTATGFSHVLQFMYYG 92

                         90
                 ....*....|....*.
gi 350405543  91 SIDVAEEHLPSLIKTA 106
Cdd:cd18244   93 TIELSMLTVHEILQAA 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  26 KSGSLTDTTLACQGGMLRAHRLVLAACSPYF-ERVFKEHYGEQPILILKGVAVEEMECLLDFMYRGSIDVAEEHLPSLIK 104
Cdd:cd18277   23 KKDVLCDVTILVEGQRFRAHRSVLAACSSYFhSRIVGQADAELNITLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCK 102

                         90
                 ....*....|
gi 350405543 105 TATDLEIRGL 114
Cdd:cd18277  103 CVEFLSVHNI 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  24 LYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVFKEHYGE---QPILILKGVAVEEMECLLDFMYRGSIDVAEEHLP 100
Cdd:cd18254   16 LRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLREsldSTVNFHDSLHPEVLELLLDFAYSSRIIINEENAE 95

                         90
                 ....*....|
gi 350405543 101 SLIKTATDLE 110
Cdd:cd18254   96 SLLEAGDMLQ 105

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350405543  22 EGLYKSGSLTDTTLACQGGMLRAHRLVLAACSPYFERVF----KE-HYGEQPILILkgvAVEEMECLLDFMYRGSIDVAE 96
Cdd:cd18263    5 EGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFtsgmKEsTQSVVQLPTI---PAKDLRLLISFAYSGILHLSW 81