|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
28-409 |
3.08e-153 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 438.58 E-value: 3.08e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 28 TIYAVYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFL 107
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 108 LLAIADTPAMLFIHKIPTIFMHVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAA 187
Cdd:cd17331 81 LLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 188 GSAFSLLLVLKFIPKNTKAETTRGNTTDDNrKKSVFNLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFK 267
Cdd:cd17331 161 GSLLSIVLVILLIPSNTKSKREKEAKESAS-PPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 268 LQPEQNGYLMAYFGIVQMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVITD 347
Cdd:cd17331 240 LTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVIT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 348533784 348 SMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFVYLL 409
Cdd:cd17331 320 SLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
32-410 |
9.04e-52 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 177.00 E-value: 9.04e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFLQFSVTPYL---AKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLL 108
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 109 LAIADTPAMLFIHKIPT-IFMHVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAA 187
Cdd:cd17330 81 LGLSRNLWLLFLARFLDgLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 188 GSAFSLLLVLKFIpkntkaettrgnttddnrkksvfnlgeitrlmkfPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFK 267
Cdd:cd17330 161 LALLNLVLVLFFL----------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 268 LQPEQNGYLMAYFGIVQMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVITD 347
Cdd:cd17330 207 FSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 348533784 348 SMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFVYLLQ 410
Cdd:cd17330 287 ALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
32-412 |
1.48e-42 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 152.77 E-value: 1.48e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAI 111
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 112 ADTPAMLFIHKIPT-IFMHVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLY-GEKFTAYFGAAGS 189
Cdd:cd17390 81 STSLALLFLSRIPLgIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 190 AFSLLLVLKFIPKntkaettrgnttddnrkksvfnLGEItrlmkfptvmqtFIIKIVAGLPSGIFQVMFSIIALEFFKLQ 269
Cdd:cd17390 161 ILNAGLVWFLLSK----------------------LWDL------------LLVRFLMGFSVLLFRSNFSLYLEERFDLS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 270 PEQNGYLMAYFGIVQMViQGGVIGRLTARYSDNSLLLL----SIGVSSLVGLAQAyiQNVWQFCLNILPMMFSLSVFNVI 345
Cdd:cd17390 207 PKTIGYLISYSGVLGAL-SGFLVGRILKLYKNNEYLLLlhsfILLALSLLGLALA--PSIWLLVLCLTPLSISSAVLRTC 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348533784 346 TDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVnYGISSIGLIQFFVNIAVFVYLLQRR 412
Cdd:cd17390 284 STSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQE-FSVSGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-412 |
2.49e-35 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 133.86 E-value: 2.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAI 111
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 112 ADTPAMLFIhkipTIFMH------VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFG 185
Cdd:cd17325 81 ATSYWQLLL----ARFLQglasaaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 186 AAGSAFSLLLVLKFIPKNTKAETTRGNTTDDNRKKsvfnlgeITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEF 265
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSG-------LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 266 FKLQPEQNGYLMAYFGIVQMVIQGgVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVI 345
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQP-PAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348533784 346 TDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFVYLLQRR 412
Cdd:cd17325 309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-372 |
3.41e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 124.70 E-value: 3.41e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 24 SQMTTIYAVYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTV 103
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 104 VFFLLLAIADTPAML----FIHKIPTIFMHvlPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEK 179
Cdd:COG2814 87 LGSLLCALAPSLWLLlaarFLQGLGAGALF--PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 180 FTAYFGAAGSAFSLLLVLKFIPKNTKAETTRGnttddnrkksvfnLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFS 259
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARL-------------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 260 IIALEFFKLQPEQNGYLMAYFGIVQMVIQgGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSL 339
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|...
gi 348533784 340 SVFNVITDSMLTKSVPSSDTGTMLGLCASVQSL 372
Cdd:COG2814 311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
32-385 |
1.77e-31 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 123.51 E-value: 1.77e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFLQFSVTPYLAKKLGFDT----LWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFL 107
Cdd:cd17388 4 ILVTVLLDAMGIGLIMPVLPTLLREFVGDSadaaTHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 108 LLAIADTPAMLFIHKIPTIFMHVLPASQM-VVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKlYGEKFTAYFGA 186
Cdd:cd17388 84 LMAFAPTLWWLYLGRIIAGITGATGAVAAaYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 187 AGSAFSLLLVLKFIPKNTKAETTRgnttdDNRKKSVFNLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFF 266
Cdd:cd17388 163 GLNGLNFLLGLFVLPESLPPERRR-----AFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 267 KLQPEQNGYLMAYFGIVQMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQfclnILPMMFSLSVFNVIT 346
Cdd:cd17388 238 DWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWM----VFPILILLALGGIAG 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 348533784 347 ---DSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLY 385
Cdd:cd17388 314 palQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIF 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-409 |
3.48e-21 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 94.22 E-value: 3.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 41 TWMFLQfsVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLA-CASTVVFFLLLAIADTPAMLF 119
Cdd:cd06173 15 DWIFTV--ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdLLRALLAAVLALLALLGSLSL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 120 IHKIPTIFMHVL------PASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSL 193
Cdd:cd06173 93 WLLLVLAFLLGIasaffgPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 194 LLVLkFIPKNTKAETTRGNTTDDNRKKsvfnlGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFKLQPEQN 273
Cdd:cd06173 173 LLLL-FIRRPPPAAPGESSSLLLRDLR-----EGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 274 GYLMAYFGIvQMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVITDSMLTKS 353
Cdd:cd06173 247 GLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 348533784 354 VPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFVYLL 409
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-406 |
9.44e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.10 E-value: 9.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAI 111
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 112 ADTPAML----FIHKIPTIFMhvLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQL-SKLYGEKFTAYFGA 186
Cdd:cd06174 81 APSFWLLllgrFLLGLGSGLI--DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILaSSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 187 AGSAFSLLLVLKFIPKNTKAETTRGNTtddnRKKSVFNLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFF 266
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNE----EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 267 KLQPEQNGYLMAYFGIVQMVIqGGVIGRLTARYSDNS-LLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVI 345
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALG-SLLLGLLSDRLIGRKpLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 348533784 346 TDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFV 406
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-378 |
1.59e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.32 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 29 IYAVYLIAALDitWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLL 108
Cdd:pfam07690 1 LFLAAFLAALG--RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 109 LAIADTPAMLFIHKIPTIFMH--VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGA 186
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 187 AGSAFSLLLVLKFIPKntkaettRGNTTDDNRKKSVFNLGEITRLMKFPTVMQTFIIKIVAGLPSGIFqVMFSIIALEFF 266
Cdd:pfam07690 159 ILSLLAAVLLLLPRPP-------PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGL-LTYLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 267 KLQPEQNGYLMAYFGIVqMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMM---FSLSVFN 343
Cdd:pfam07690 231 GLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgFGFGLVF 309
|
330 340 350
....*....|....*....|....*....|....*
gi 348533784 344 VITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGP 378
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-409 |
8.33e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 78.42 E-value: 8.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 40 ITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLF 119
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 120 IHKIPTIFMHVL--PASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQlskLYGEKFTAYFGAAGSAFSL-LLV 196
Cdd:cd17329 93 IALVLTGFGGGLfePASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL---LLLYSFRLLFLAAAVLFLLaALV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 197 LKFIPKNTKAETTRGNTTDDnrkksvfnLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFKLQPEQNGYL 276
Cdd:cd17329 170 LLFLLPETRPKRRAAEKTEI--------LRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 277 MAYFGIVQMVIQgGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPM----MFSLSVFNVITDSMltk 352
Cdd:cd17329 242 LALNALLIVLLQ-FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLtlgeMLVFPAVQTLVAAL--- 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 348533784 353 sVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFVYLL 409
Cdd:cd17329 318 -APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
36-388 |
1.87e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 74.15 E-value: 1.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 36 AALDITWMFLQFSVTPYL---AKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIA 112
Cdd:cd17504 2 ALAALAVMLVETMLSPALptiQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 113 DT-PAMLFIHKIPTIFMHVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAF 191
Cdd:cd17504 82 PNlPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 192 SLLLVlKFIPkntkaettrgnttddnrkksvfnlgeiTRLMKFPTVMQTFIIKIVAGLpsGIFQVMFSIIAL------EF 265
Cdd:cd17504 162 LAALV-PLID---------------------------LRLLRRRNVLLANITALLAGF--GMFMVFQLLPQLlqlptpTG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 266 FKLQPEQNGYLMAYFGIVQMVIqGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYI-QNVWQFCLNILPMMFSLSVFNV 344
Cdd:cd17504 212 FGLGITEAGLLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFA 290
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 348533784 345 ITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNY 388
Cdd:cd17504 291 SLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTY 334
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
49-412 |
5.56e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 69.91 E-value: 5.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 49 VTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKIPTIFM 128
Cdd:COG2223 27 LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 129 H--VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPkntka 206
Cdd:COG2223 107 GggSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 207 ettrgNTTDDNRKKSVFNLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFKLQPEQNGYLMAYFGIVQMV 286
Cdd:COG2223 182 -----DPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGAL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 287 IqGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQ-NVWQFCLNILPMMFSLSVFNVITDSMLTKSVPSSDTGTMLGL 365
Cdd:COG2223 257 G-RPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGL 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 348533784 366 CASVQSLLRTVGPTIGGFLYVNYGISSIGL---IQFFVNIAVFVYLLQRR 412
Cdd:COG2223 336 VGAAGGLGGFLGPLLFGALLDATGSYTAAFlvfAVLALVALVLTLLLYRR 385
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-408 |
3.45e-12 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 67.29 E-value: 3.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 62 LWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLAC-ASTVVFFLLLAIADTPAMLFIHKIPTIFMHVLPASQMVVTD 140
Cdd:cd17391 36 LWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASlGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 141 LTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNTKAETTRGNTTDDNRKK 220
Cdd:cd17391 116 QTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWN 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 221 SVFNLGEItrlmkFPTVMQTFIIKIVAglpsgifQVMFSIIALEFFKL-QPEQN-----GYLMAYFGIVQMvIQGGVIGR 294
Cdd:cd17391 196 SVPNPSLL-----ISLFVTTFIIQLAN-------QSIEPILTLYIRQLmGDASNlafisGLVFSATGVSSL-LSAPRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 295 LTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQfcLNILPMMFSLSVFNVI--TDSMLTKSVPSSDTGTMLGLCASVQSL 372
Cdd:cd17391 263 LGDRIGHHRILLGALLASALLYIPQAFVQTPWQ--LGILRFLLGLATGGLLpaINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
330 340 350
....*....|....*....|....*....|....*.
gi 348533784 373 LRTVGPTIGGFLYVNYGISSIgliqfFVNIAVFVYL 408
Cdd:cd17391 341 GNVAGPLLGSAIAAHFGYRAV-----FVVTALLVLL 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-415 |
1.22e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.58 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 49 VTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIhkiptifM 128
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLL-------L 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 129 HVL---------PASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLvlkf 199
Cdd:COG2271 105 RFLlglgeagffPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 200 ipkntkaettrgnttddnrkksvfnlgeitrlmkfpTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFKLQPEQNGYLMAY 279
Cdd:COG2271 181 ------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 280 FGIVQMViqGGVI-GRLTARYSDNSLLLLSIG--VSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVITDSMLTKSVPS 356
Cdd:COG2271 225 PFLAGIV--GSLLgGWLSDRLGRRRKLVLAIGllLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 348533784 357 SDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNI--AVFVYLLQRRLNK 415
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALlaALLALLLLRETRK 363
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
82-409 |
1.18e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 59.54 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 82 FGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLfihkiptIFMHVLPASQMV-------VTDLTKPEKRADALSKL 154
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGL-------ILGRALQGSGAIssvvmalLADLTREENRTKAMALI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 155 GLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNTKAETTRgnttdDNRKKSVFNLGEITRLMKF 234
Cdd:cd17472 125 GASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQIS-----EKEKKKLKKLLKNKRLLRL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 235 PTVMqtFIIKIVAglpsgifQVMFSIIALEFFKLQPEQNGYLMAYfgiVQMVIQGGVIGRLTARYSDNSLLLLSIGVSSL 314
Cdd:cd17472 200 DFSI--FILHFVL-------MAFFYILPLLLTQLGGGKGQLWKVY---LPAILIGFILMVPFVIYAEKKGKMKQVFVSSI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 315 VGLAQAYI------QNVWQFCLNILPMMFSLSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNY 388
Cdd:cd17472 268 LLIAVGFLlllfaaTSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLL 347
|
330 340
....*....|....*....|.
gi 348533784 389 GISSIGLIQFFVNIAVFVYLL 409
Cdd:cd17472 348 GYSSVFLTILILALLWLLVSF 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-406 |
2.06e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 29 IYAVYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLL 108
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 109 LAIADT-PAMLFIHKIPTI-FMHVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGekFTAYFGA 186
Cdd:cd17474 81 CGLSDSfALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISW--RYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 187 AGSAFSLLLVLKFIPKNTKAETTRGNTTDDNRKKSVFNlGEITRLMKFPTVMQTFIIkivaglpsGIFQVMFSIIALEFF 266
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALR-GRGLLTFLVSAFLYFFLY--------FAFLTYLPFLLELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 267 KLQPEQNGYLMAYFGIVQMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVIT 346
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 347 DSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIgliqFFVNIAVFV 406
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP----FLVGAAIAL 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
240-421 |
2.81e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 2.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 240 TFIIKIVAGLPSGIFQVMFSIIALEFFKLQPEQNGYLMAYFGIVQMVIQGgVIGRLTARYSDNSLLLLSIGVSSLVGLAQ 319
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQP-LAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 320 AYIQNVWQFCLNILPMMFSLSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFF 399
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180
....*....|....*....|..
gi 348533784 400 VNIAVFVYLLQRRLNKTAKQRK 421
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPK 181
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-205 |
2.98e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 2.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 27 TTIYAVYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGAR--TALSLACASTVV 104
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 105 FFLLLAIADTPAMLFIHKIPTIFMH--VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTA 182
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLggAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|...
gi 348533784 183 YFGAAGSAFSLLLVLKFIPKNTK 205
Cdd:COG2271 341 LLLAALALLAALLALLLLRETRK 363
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
36-384 |
4.22e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 4.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 36 AALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFAD----LFGARTALSLACA--STVVFFLL- 108
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAipLALSFVLLf 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 109 LAIADTPAMLFIHKIPT-IFMHVLPASQMV-----VTDLTK-PEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGE--- 178
Cdd:COG2211 100 TAPDLSPTGKLIYALVTyLLLGLAYTLVNIpysalGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGdaa 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 179 ---KFTAYFGAAGSAFSLLLVLKFIPKNTKAETTRGNTTDDnrkksvfnlgeITRLMKFPTVMQTFIIKIVAGLPSGIFQ 255
Cdd:COG2211 180 lgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES-----------LKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 256 VMFSIIALEFFKLQPEQNGYLMAYFGIVQMVIQgGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQ--NVWQFCLNIL 333
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 348533784 334 PMMFSLSVFNVITDSMLTKSVPSSDTGTML---GLCASVQSLLRTVGPTIGGFL 384
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDYDEWKTGRrreGLYFGIFTFAIKLGQALAGAL 381
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
44-390 |
7.17e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 57.21 E-value: 7.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 44 FLQFSVT----PYLA---KKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLAC--ASTVVFFLLLAIADT 114
Cdd:cd17335 7 FFFFAALgsllPFLSvylKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSllAAVLFFLSLFFVAQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 115 PAMLFIHKIPTIFMH--VLPASQMVVTDLTKpEKRADaLSKLGLCFGIGMIVGSTLGGQL----SKLYGEKFTAYFGAAG 188
Cdd:cd17335 87 FWLLLLLVILGAFFSapVVPLVDSITLQYLG-EERER-YGKQRLWGSIGFGIAALLVGILidrsSTYKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 189 SAFSLLLVLKFIPkntkaettrgnttDDNRKKSVFNLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVmFSIIALEFFKL 268
Cdd:cd17335 165 MLLALLLALKFPF-------------RPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYS-FLFWHLQDLGG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 269 QPEQNGYLMAyFGIVQMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWqFCLNILPMM-FSLSVFNVITD 347
Cdd:cd17335 231 SKTLIGLLWT-VGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPW-LVLPIELLHgLTFALVWAAAV 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 348533784 348 SMLTKSVPSSDTGTMLGLCASVQS-LLRTVGPTIGGFLYVNYGI 390
Cdd:cd17335 309 SYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGA 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
51-297 |
1.55e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.59 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 51 PYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLfihkiptIFMHV 130
Cdd:COG0477 38 PSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELL-------IAARA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 131 L---------PASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIP 201
Cdd:COG0477 111 LqgigagglmPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 202 KNTKAETTRGNTTDDNRKKSVFNLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFKLQPEQNGYLMAYFG 281
Cdd:COG0477 191 SRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLL 270
|
250
....*....|....*.
gi 348533784 282 IVQMVIQGGVIGRLTA 297
Cdd:COG0477 271 LLALLLALLLLLLLLL 286
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
77-396 |
1.69e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.02 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 77 LGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKIPTIFMH--VLPASQMVVTDLTKPEKRADALSKL 154
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHggFWAIAAAYAADLVPPEKRGRAIGLV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 155 GLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKntkaettrgntTDDNRKKSVFNLGEITRLMKF 234
Cdd:cd17324 129 FSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS-----------LPPKKPGSLGLLSSLLLLLRN 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 235 PTVMQTFIIkivAGLPSGIFQVMFSIIAL---EFFKLQPEQNGYLMAYFGIVqMVIQGGVIGRLTARYSDNSLLLLSIGV 311
Cdd:cd17324 198 PRLRLAYLI---TFLLFGGFFALYTYLAPfltDVPGFSSSAIIGLLLLFGVA-GVVGSPLAGRLADRGGRRALLIALLLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 312 SSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVITDSMLTKSVPsSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGIS 391
Cdd:cd17324 274 AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA 352
|
....*
gi 348533784 392 SIGLI 396
Cdd:cd17324 353 GVGWV 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
44-411 |
1.92e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.68 E-value: 1.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 44 FLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKI 123
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 124 ptifMH------VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVL 197
Cdd:cd17489 93 ----IHgigwgaFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 198 kFIPKNTKAETTRGNTTDDNRKKSVfnlgeitrlmkFPTVMQTFIIKIVAGLPSGIFQvmfSIIALEFFKLQPEQNGYLM 277
Cdd:cd17489 169 -LVKDPPPVAAEEAEAGTRAFRRLV-----------EKKVLPPALILFLASIAYGAIS---TFLPLYAAERGISNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 278 AYFGIVqMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLN--ILPMMFSlSVFNVITdSMLTKSVP 355
Cdd:cd17489 234 TVYAIA-LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAavLYGLGFG-LLFPALQ-ALAVDLVP 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 348533784 356 SSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSI-GLIQFFVNIAVFVYLLQR 411
Cdd:cd17489 311 PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMfLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
29-197 |
2.09e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 55.63 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 29 IYAVYLIAALDITWMFLQfsvtpYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLL 108
Cdd:cd17370 206 LLAVALFALGNFSFAFLI-----LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 109 LAIADTPAMLFIhkiPTIFMHVLPASQ-----MVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAY 183
Cdd:cd17370 281 FALGSSLWLLLL---GFILWGLYMGAQesierAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|....
gi 348533784 184 FGAAGSAFSLLLVL 197
Cdd:cd17370 358 FSAVLALIALLLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
34-162 |
2.88e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.98 E-value: 2.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 34 LIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIAD 113
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG 294
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 348533784 114 TPAMLFIHKIPTIFMH--VLPASQMVVTDLTKPEKRADALSKLGLCFGIGM 162
Cdd:COG2814 295 SLWLLLLALFLLGFGFglLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
29-416 |
3.42e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.25 E-value: 3.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 29 IYAVYLIAALdITWMFLqfSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLL 108
Cdd:COG0738 13 IYLLFFLWGF-ATALWG--PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 109 LAIADTPAM----LFIHKIPTIFMHVlpASQMVVTDLTkPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKF--TA 182
Cdd:COG0738 90 FALAPSYPLlllaLFLLGLGLGLLDV--AANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSwhLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 183 YFGAAGSAFSLLLVLKFIPKNTKAETTRGNTTDDNRKKSVFnlgeitrlmKFPTVMQTFIIKIVAGLPSGIFQVMFSIIA 262
Cdd:COG0738 167 YLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLL---------KNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 263 LEFFKLQPEQNGYLMAYFGIVQMViqGGVIG-RLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQ----------FCLN 331
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTI--GRFLGgFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaliglalvglGLSL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 332 ILPMMFSLSVfnvitdsmltkSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFL--YVNYGISSIGLIQFFVNIAVFVYLL 409
Cdd:COG0738 316 MFPTIFSLAL-----------DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLadAFGLRAAFLVPLVCYLLILLLALAL 384
|
....*..
gi 348533784 410 QRRLNKT 416
Cdd:COG0738 385 KRKRRKK 391
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
32-384 |
6.46e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.10 E-value: 6.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAI 111
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 112 ADTPAMLFIHKiptIFMHVLPASQMVVTD-----LTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSklYGEKFTAYFGA 186
Cdd:cd17477 81 TDSPWVWFLLR---FVMGIGLAGLFVVSEswlnaLATNENRGRVLGLYSTVLGLGFALGPLLLALVG--TAGALPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 187 AGSAFSLLLVLkFIPKNTKAETtrgnttddnrKKSVFNLGEITRLMKFPtvmqtFIIKIVAGLPSGIFQVMFSIIALEfF 266
Cdd:cd17477 156 VLLLLALVPLL-LTRRAAPEIE----------EAESISLRRLLRIAPLA-----LLGAFVAGFLEGAFYSLLPLYGLR-L 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 267 KLQPEQNGYLMAYFGIVQMVIQgGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPM--MFSLSVFNV 344
Cdd:cd17477 219 GLSVAQAALLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLwgGAAGPLYTL 297
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 348533784 345 ITdSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFL 384
Cdd:cd17477 298 AL-ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
32-197 |
8.17e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 8.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFLQFS-VTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLA 110
Cdd:cd17324 203 AYLITFLLFGGFFALYTyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 111 IADTPAMLFIHKIP--TIFMHVLPASQMVVTDLTkPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAG 188
Cdd:cd17324 283 LGPSPLLLLVGLVLwgLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAAL 361
|
....*....
gi 348533784 189 SAFSLLLVL 197
Cdd:cd17324 362 LLLALLLAL 370
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
62-411 |
1.85e-07 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 52.66 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 62 LWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKI-PTIFMHVLPASQMVVTD 140
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIvGGISKGNVSLSTAIVAD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 141 LTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSkLYGEKFTAYFGAAGSAFSLLLvlkfipkntkaettrgnttddnrkk 220
Cdd:cd17389 144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFA-SFTRSLGEVFFSMPALFALVL------------------------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 221 SVFNLgeITRLMKFPTVMQTFIIKIvaGLPSGIFQVMFSiiALEF---------FKLQPEQNGYLMAYFGIVQMVIQGGV 291
Cdd:cd17389 198 ALADL--LFIFFFLPETLPSNLRRL--GLVYFLYLFLFS--GLEFtltflthqrFQYTSMQQGKMFFFIGIIMALVQGGY 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 292 IGRLTA----RYSDNSLLLLsIGVSSLVGLAqayiQNVWQFCLNILpmMFSLSVFNVIT--DSMLTKSVPSSDTGTMLGL 365
Cdd:cd17389 272 VRRIKPgkekKAVLQGLILL-IPAFLLIGWA----SSVTVLYAGLF--LYSFAAATVVPclTTLVSGYGSDDQKGTVMGI 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 348533784 366 CASVQSLLRTVGPTIGGFLYVNYGiSSIGLIQFFVNIAVFVYLLQR 411
Cdd:cd17389 345 FRSLGALARALGPIVACTVYWLAG-SEACYTIGALLFLLPLLLLAR 389
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
29-409 |
2.13e-07 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 52.60 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 29 IYAVYLIAALDITWMFLQF-SVTPYLAK-KLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFG-ARTALSLACASTVVF 105
Cdd:cd17326 1 IYVMYLTMFLSSLQFSIVLtSIWPYLQKiDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 106 FLLLAIADTPAMLFIHKIPTIFMHVLPASQMV------VTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKL---- 175
Cdd:cd17326 81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVavlrayVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIgypg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 176 --YGEKF-------TAYFGAAGSAFSLLLVLkfipkntkaettrgnttddnrkksvFNLGEITRLMKFPTVMQTFIikiv 246
Cdd:cd17326 161 yvIGIKLrfnmytaPAWLMAILGIINIILIL-------------------------FFFKEVVCIFLFFVVLFIFA---- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 247 aglpsgIFQVMFSIIALEFFKLQPEQ----NGYLMAYFGIVQMVIQGGVIGRLTARYSDNSLLLLSIGVsSLVGLAQAYi 322
Cdd:cd17326 212 ------NLETIGTPLTMDMYGWTREEavlyNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLIL-FFLGFVVTL- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 323 qnVWQFCLNILpMMFSLSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNI 402
Cdd:cd17326 284 --PWGITGVIL-FGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLL 360
|
....*..
gi 348533784 403 AVFVYLL 409
Cdd:cd17326 361 LAIILLI 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
245-409 |
3.15e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 3.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 245 IVAGLPSGIFQVMFSIIALEFfKLQPEQNGYLMAYFGIVQMVIQGgVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQN 324
Cdd:COG2814 20 FLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAP-LAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 325 VWQFCLNILPMMFSLSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAV 404
Cdd:COG2814 98 LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA 177
|
....*
gi 348533784 405 FVYLL 409
Cdd:COG2814 178 LLLLL 182
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-201 |
3.50e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.89 E-value: 3.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 8 NEETDKASVSSKvaddsQMTTIYAVYLIAALD-ITWMFLQFSVtPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFA 86
Cdd:TIGR00895 3 QNNIRKQPLSRY-----QWRAIILSFLIMLMDgYDLAAMGFAA-PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 87 DLFGARTALSLACASTVVFFLLLAIA-DTPAMLFIHKIPTIFM-HVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIV 164
Cdd:TIGR00895 77 DRIGRRRVLLWSILLFSVFTLLCALAtNVTQLLILRFLAGLGLgGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAV 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 348533784 165 GSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIP 201
Cdd:TIGR00895 157 GGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
31-172 |
4.00e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.71 E-value: 4.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 31 AVYLIAALDITWMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLA 110
Cdd:cd17321 173 AVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLA 252
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348533784 111 IADTPAMLFIHKIPTIFMHV-----LPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQL 172
Cdd:cd17321 253 LLGADSSVWLLLPGLVLLGLglglfATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
52-197 |
5.97e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.93 E-value: 5.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 52 YLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKIPT-IFMHV 130
Cdd:cd17471 225 YVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNaIFIGI 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348533784 131 LPASQMV-VTDLtKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVL 197
Cdd:cd17471 305 TAGLGISyFQDL-MPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
29-406 |
1.04e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 29 IYAVYLIAALDITWMFLQFSVTPYLAK--KLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFF 106
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 107 LLLAIADTPAMLFIHKIPT-IFMH-VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFT--- 181
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQgIGIGgEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwri 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 182 AYFGAAGSAFSLLLVLKFIpkntkaettrgnttddnrkksvfnlgeitrlmkfptvMQTFIIKIVAGLPSGIFQVMFSII 261
Cdd:cd17316 161 LFLIGALPALLALLLRRRT-------------------------------------LLLILLWFFISFGYYGLTTFLPTY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 262 ALEFFKLQPEQNGYLMAYFGIVQMViqGGVI-GRLTARYSDNSLLLLSIGVSSLVGLAQAYI--QNVWQFCLNILPMMFS 338
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALV--GALIaGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFF 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348533784 339 LSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFV 406
Cdd:cd17316 282 VGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-177 |
2.55e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 43 MFLQFSVTPYLAKK-LGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTP------ 115
Cdd:COG2211 244 LALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlwlll 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 348533784 116 AMLFIHKIPTIFMHVLPASqmVVTDLTKPEKRADALSKLGLCFGI-------GMIVGSTLGGQLSKLYG 177
Cdd:COG2211 324 VLAALAGIGLGAILVLPWA--MLADVVDYDEWKTGRRREGLYFGIftfaiklGQALAGALAGLLLALFG 390
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
49-409 |
3.05e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 49 VTPYlAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTA-LSLACASTVVFFLLLAIADTPAMLFIHKIPTIF 127
Cdd:cd17490 19 LSPY-AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 128 MHVLPASQMVV-TDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNTKA 206
Cdd:cd17490 98 AAATWVSFTVLyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 207 ettrgnttddnrKKSVFNLGEITRLMKFPTVMqtfIIKIVAGLPSGI-FQVMFS---IIALEFFKLQPEQNGYLMAYFGI 282
Cdd:cd17490 178 ------------KPVLTELKELLSVLKDKKLL---FFSLLAILQQMItFSTTFGftpLIAKQLGASSFQLGLLSIIYLLP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 283 VQMVIQGGVIGRLTaRYSDNSLLLLSIGVSSLVGLAQAYIQNVWQ-FCLNILPMMFSLSVFNVITdSMLTKSVPSSDTGT 361
Cdd:cd17490 243 NALASLLSGTLFYK-KLGERNTIIIGFLLLGAYCFLIPFAPNLTLlYLLQALNGFGTGILFPLLM-SLSIEGVPAEQRST 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 348533784 362 MLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFVYLL 409
Cdd:cd17490 321 AMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
72-409 |
4.96e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 45.26 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 72 GVIQLLGGPmfgrFADLFGARTALslacastvVFFLLLAIADTPAMLFIHKIPT-IFMHVLPA---------SQMVVTDL 141
Cdd:cd17320 48 ALGQLLYGP----LSDRFGRRPVL--------LAGLLLFILASLLCALASSIEQlLIARFLQGlgaaagsvvARAIVRDL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 142 TKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNTKAETTRgnttddnrkks 221
Cdd:cd17320 116 YSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRK----------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 222 vFNLGEITRLMKFPTVMQTFIIKIVAGlpSGIFQVMFSIIALEFFKLQpEQNGYLMAYFGIVQMVIQGGVI------GRL 295
Cdd:cd17320 185 -PLLSSLLRAYKRVLKNRRFLGYALAL--GLSFAGLFAYLAAAPFIYI-EQLGLSPAQFGLLFALNAIALIlgsllnGRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 296 TARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLN--ILPMMFSLSVFNVITDSMLTK--SVPSSDTGTMLGLCASVQS 371
Cdd:cd17320 261 VRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWplVAPLFLIFFGFGLIFPNATSLalEPFPHVAGTASALLGFLQF 340
|
330 340 350
....*....|....*....|....*....|....*...
gi 348533784 372 LLRTVGPTIGGFLYvNYGISSIGLIQFFVNIAVFVYLL 409
Cdd:cd17320 341 LIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
65-202 |
5.07e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.27 E-value: 5.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 65 GYLQTTVGVIQLLGG----PMF---GRFADLFGARTALSLACASTVVFFLLLAIADTPAMLfihkIPTIFMH------VL 131
Cdd:cd17335 229 GGSKTLIGLLWTVGVvseiPFFffsSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV----LPIELLHgltfalVW 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 348533784 132 PASQMVVTDLTKPEKRADALSKL-GLCFGIGMIVGSTLGGQLSKLYGEkFTAYFGAAGSAFSLLLVLKFIPK 202
Cdd:cd17335 305 AAAVSYASAAAPPGLRATAQGLLqGLYFGLGGGLGSLIGGYLYEAFGA-RTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
29-201 |
5.24e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 5.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 29 IYAVYLIAALDITWMFLQFSVTP-YLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFL 107
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 108 LLAIADTPAMLFIHKIPT--IFMHVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFG 185
Cdd:cd17473 279 LLALASGLWVVLLGAILAglGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLI 358
|
170
....*....|....*.
gi 348533784 186 AAGSAFSLLLVLKFIP 201
Cdd:cd17473 359 LGVLALVLAIVLLLLR 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
245-389 |
6.20e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 245 IVAGLPSGIFQVMFSIIALEF---FKLQPEQNGYLMAYFGIVQMVIQGgVIGRLTARYSDNSLLLLSIGVSSLVGLAQAY 321
Cdd:COG2271 16 FLAYFLNYLDRSNLSVAAPPLqadLGLSAAQLGLLASAFFLGYALGQI-PAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348533784 322 IQNVWQFCLNILPMMFSLSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYG 389
Cdd:COG2271 95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
49-318 |
1.70e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 49 VTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFihkIPTIFM 128
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL---AGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 129 HV-LPASQMVVTDLTK---PEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNT 204
Cdd:COG2807 117 GAgIAVGNVLLPGLIKrwfPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 205 KAETTRGNTTDdnrkksvfnlgeITRLMKFPTVMQtfiIKIVAGLPSGIFQVMFSIIA--LEFFKLQPEQNGYLMAYFGI 282
Cdd:COG2807 197 AAAAAAPAAAS------------LRSLWRSPLAWL---LTLFFGLQSLLYYAVVAWLPpiLRDAGLSAATAGLLLSLFQL 261
|
250 260 270
....*....|....*....|....*....|....*.
gi 348533784 283 VQMVIqGGVIGRLTARYSDNSLLLLSIGVSSLVGLA 318
Cdd:COG2807 262 AGIPG-SLLVPLLADRLGDRRPLLLLLGLLGLAGLL 296
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
47-409 |
2.09e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 47 FSVTPYLAKKLGFDTLWFGYLqttVGVIQLLGGPM---FGRFADLFGARTALslacasTVVFFLLLAIAdTPAMLFIHKI 123
Cdd:cd17370 19 RSILPLFLVVLGASAAAVGLI---EGLAEALGSLLrlfSGYLSDRTGKRKPL------VILGYGLSALA-KPLLALAGSW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 124 PTIFMHVL----------PASQMVVTDLTKPEKRadalsklGLCFGI-------GMIVGSTLGGQLSKLYGEKFTAYFGA 186
Cdd:cd17370 89 QLVLLLRIlerlgkgirtPPRDALLADATPPSGR-------GKAFGLhraldtlGAVLGPLLAALLLYLLGGNYRTIFLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 187 AG--SAFSLLLVLKFIPKNTKAETTRGNTTDdnrkksvfnlgeiTRLMKFPTVMQTFIIkIVAGLPSGIFQVMFSIIALE 264
Cdd:cd17370 162 AAipALLALLILLFVVKEYPRPPKLRKKSKK-------------TSLKKLPKAFWLYLL-AVALFALGNFSFAFLILRAQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 265 FFKLQPEQNGYLMAYFGIVQMVIqGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNV 344
Cdd:cd17370 228 ELGLSAALIPLLYALFNLVYALA-AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 348533784 345 ITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAVFVYLL 409
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
77-385 |
3.30e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.64 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 77 LGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKIPTIFMHVL---PASQMVVTDLTKPEKRADALSK 153
Cdd:cd17355 53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGtlaAVAFATVAAWWFERRRGLALGI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 154 LGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNTKAETTRGNTTDDNRKKSVFnLGEITRLMK 233
Cdd:cd17355 133 LTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGST-LKEALRSAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 234 FPTVMQTFIIkivAGLPSGIFQVMFsIIALEFFKLQPEQNGYLMAYFGIVQMViqGGV-IGRLTARYSDNSLLLLSIGVS 312
Cdd:cd17355 212 FWLLALAFFL---CGFAVVGLIVHL-VPYLADRGISPAAAAVALALIGLFNIV--GRLlSGWLGDRYSPRRLLAASYALR 285
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 348533784 313 SLVGLAQAYIQNVwQFCLNILPMMFSLSVFNVITDSMLT--KSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLY 385
Cdd:cd17355 286 ALGLALLLLLPFP-PLALLLFAALFGLGWGATVPLTAALaaRYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
245-409 |
7.62e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 7.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 245 IVAGLPSGIFQVMFSIIaLEFFKLQPEQNGYLMAYFGIVQMVIQGgVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQN 324
Cdd:cd06174 6 FLTGLARGLISPLLPAL-LQSFGLSASQLGLLFALFSLGYALLQP-LAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 325 VWQFCLNILPMMFSLSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFLYVNYGISSIGLIQFFVNIAV 404
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALAL 163
|
....*
gi 348533784 405 FVYLL 409
Cdd:cd06174 164 LAAIL 168
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
42-207 |
8.80e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 8.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 42 WMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFI- 120
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLv 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 121 -HKIPTIFMHVLPASQM-VVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAG-SAFSLLLVL 197
Cdd:COG2223 301 lFLLLGLALGGGNGAVFaLVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVlALVALVLTL 380
|
170
....*....|
gi 348533784 198 KFIPKNTKAE 207
Cdd:COG2223 381 LLYRRPRRAA 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
32-199 |
9.87e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 9.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 32 VYLIAALDITWMFL--QFSVTPYLAKK-LGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLL 108
Cdd:cd06173 211 RLLLLALALFALLGgaLTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 109 LAIADTP----AMLFIHKIPTIFmhVLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYF 184
Cdd:cd06173 291 LGLSPSLwlllAALFLLGLAGGL--FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
170
....*....|....*
gi 348533784 185 GAAGSAFSLLLVLKF 199
Cdd:cd06173 369 AGALLLLAALLLLLL 383
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-196 |
1.60e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 47 FSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIAD--TPAMLFIHKIP 124
Cdd:cd17477 208 YSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPglPLALLVLLFLW 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 348533784 125 TIFMHVL-PASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLV 196
Cdd:cd17477 288 GGAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
65-385 |
2.36e-03 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 40.10 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 65 GYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIadTPAMLF-IHKIPTIFMHVLPASQMVVTDLTK 143
Cdd:cd17387 39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI--SPWWYFaMISVSGIFSVTFSVIFAYVADITT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 144 PEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNTKAETTRGNTTDDNRKKSVF 223
Cdd:cd17387 117 EEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAPISWEQAD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 224 NLGEITRLMKFPTVMQTFIIKIVAGLP-SGIFQVMFSIIALEfFKLQPEQNGYLMAYFGIVQMVIQGGVIGRLTARYSDN 302
Cdd:cd17387 197 PFASLRKVGKDKTVLLICITVFLSYLPeAGQYSSFFVYLKQV-MGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 303 SLLLLSIGVSSLVGLAQAYIQNVWQFCL-NILPMMFSLSvFNVITdSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIG 381
Cdd:cd17387 276 NTILLGLGFQMLQLAWYGFGSQHWMMWAaGAVAAMSSIT-FPAIS-ALVSRYADPDQQGAVQGMITGIRGLCNGLGPALF 353
|
....
gi 348533784 382 GFLY 385
Cdd:cd17387 354 GFVF 357
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
80-387 |
2.38e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 80 PMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLfihkiptIFMHVL---------PASQMVVTDLTKPEKRADA 150
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-------IAARALqgigaaaimPASLALIAATFPGERRGRA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 151 LSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFSLLLVLKFipkntkaetTRGNttddnrkksvfnlgeitr 230
Cdd:cd17321 122 LGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF---------SGAV------------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 231 lmkfptvmqtfiikIVAGLPSGIFQVMFSIIALEF---FKLQPEQNGYLMAYFGIVqMVIQGGVIGRLTARYSDNSLLLL 307
Cdd:cd17321 175 --------------LAAFLLGAALGGLLFLLPLYLqgvLGYSPLQAGLALLPLALA-MLVAAPLAGRLADRFGPRLVLVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 308 SIGVSSLVGLAQAYI---QNVWQFCLNILPMMFSLSVFNVITDSMLTKSVPSSDTGTMLGLCASVQSLLRTVGPTIGGFL 384
Cdd:cd17321 240 GLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
...
gi 348533784 385 YVN 387
Cdd:cd17321 320 LTA 322
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
28-197 |
2.75e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 28 TIYAVYLIAALDITWMFLQFSVTPYLAKK-----LGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSL-ACAS 101
Cdd:cd17504 178 NVLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIgLVIS 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 102 TVVFFLLLAIADTPAMLFIHK-IPTIFMHVLPASQMVVTDLTKPEKR-ADALSKLGLCFGIGMIVGSTLGGQLSKLYGEK 179
Cdd:cd17504 258 AVGLLLLALLHSSLWALVVALlLIGIGLGLAFASLPNIVVESVPPDRtGIATGMNTVLRTIGSAIGPAIAGAILTTYTVS 337
|
170
....*....|....*...
gi 348533784 180 FTAYFGAAGSAFSLLLVL 197
Cdd:cd17504 338 ITSGGVPTEGAYVLAFLI 355
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
68-204 |
3.10e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.49 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 68 QTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADT----PAMLFIHKIPTIFMHVlpASQMVVTDLTK 143
Cdd:cd17317 31 QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSyelfLVLRFLVGVTSAGIFT--VGFVLGMEIVG 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 348533784 144 PEKRADALSKLGLCFGIGMIVgstLGGqLSKLYGEKFTAYFGAAGSAFSLLLVLKFIPKNT 204
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYML---LAL-LAYLIRDWRWLQLAISLPGLLFLLLLWWLPRRT 165
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
35-213 |
3.32e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 39.67 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 35 IAALDITwmfLQFSVTPYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADT 114
Cdd:TIGR00711 13 MAVLDST---IVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 115 PAMLFIHKIPTIFMH--VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKFTAYFGAAGSAFS 192
Cdd:TIGR00711 90 LELMIIFRVIQGFGGgpLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIV 169
|
170 180
....*....|....*....|.
gi 348533784 193 LLLVLKFIPKNTKAETTRGNT 213
Cdd:TIGR00711 170 VVVAFFILPRDKPAASENFDF 190
|
|
| PUCC |
pfam03209 |
PUCC protein; This protein is required for high-level transcription of the PUC operon. |
41-384 |
3.49e-03 |
|
PUCC protein; This protein is required for high-level transcription of the PUC operon.
Pssm-ID: 367394 Cd Length: 401 Bit Score: 39.26 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 41 TWMFLQFSVTPYLAkkLGFDTLWFGYLQTTVGVIQLLGgpmfgrFADLFGARTALSLACAstVVFFLLLAIAdtpamlfI 120
Cdd:pfam03209 40 THRALGWKRTPYIW--LGSLAQAGGLAIMPFALIVLSG------SGDANGAPTWAGLILA--AVAFLLYGLG-------V 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 121 HKIPTIFMhvlpasqMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGE----KFTAYFGAAGSAFSLLLV 196
Cdd:pfam03209 103 HMSQTPGL-------ALAADLADEERRPKVVGIMWVMLLIGIIVSAITVGWLLDDYTParliRVIQGVALITFVLNIIAL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 197 LKFIPKNTKAETTRGnttddnRKKSVFnLGEITRLMKFPTVMQTFIIKIVAGLPSGIFQVMFSIIALEFFKLQPEQNGYL 276
Cdd:pfam03209 176 WKIEVGRPSRPAERP------EQDPSF-LEAWLLLVAEPQALIFLFFLFLGTLAFFMQDVILEPYGGEVFGLTVGETTKL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 277 MAYFGI---VQMVIQGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCLNILPMMFSLSVFNVITDSMLTKS 353
Cdd:pfam03209 249 TAFFAGgtlVGFGLAGRVLSPGLGPGRLAGLGCLLGLPSFLALILAGLLGNVALFFAGVLLFGLGGGLFTVAALTAMMDL 328
|
330 340 350
....*....|....*....|....*....|.
gi 348533784 354 VPSSDTGTMLGLCASVQSLLRTVGPTIGGFL 384
Cdd:pfam03209 329 APEGRAGTALGAWGAAQATAAGLAGLLGGAL 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
1-169 |
4.37e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 4.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 1 MSRIGERNEETDKASVSSKVADDSQMTTIYAVYLIAALDITWMFLQFSVT---PYLAKKLGFDTLWFGYLQTTVGVIQLL 77
Cdd:cd17478 166 LLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTtflPFYLVQRGYSLVFAGLLLSLFLFAGAI 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 78 GGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKIPTIFMHVLPASQMVVTDLTKPEKRADALS-KLGL 156
Cdd:cd17478 246 GTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGlMMGL 325
|
170
....*....|...
gi 348533784 157 CFGIGMIVGSTLG 169
Cdd:cd17478 326 SFGLGGIGAPVLG 338
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
264-330 |
5.18e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.76 E-value: 5.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348533784 264 EFFKLQPEQNGYLMAYFGIVQMVIqGGVIGRLTARYSDNSLLLLSIGVSSLVGLAQAYIQNVWQFCL 330
Cdd:cd17328 27 SDFLIDDSLAGLLQTVFIISYMVL-SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
31-200 |
5.82e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 31 AVYLIAALDITWMFLQFSVTPY----LAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADL-FGARTALSLACASTVVF 105
Cdd:cd17474 199 GLLTFLVSAFLYFFLYFAFLTYlpflLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALS 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348533784 106 FLLLAIADTPAMLFIhkiPTIFMH-----VLPASQMVVTDLTKPEKRADALSKLGLCFGIGMIVGSTLGGQLSKLYGEKf 180
Cdd:cd17474 279 LLLLGFVPSLALLLI---AIVLFGlglglNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS- 354
|
170 180
....*....|....*....|
gi 348533784 181 TAYFGAAGSAFSLLLVLKFI 200
Cdd:cd17474 355 APFLVGAAIALAAAVLLALL 374
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
52-127 |
9.27e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 38.13 E-value: 9.27e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 348533784 52 YLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVVFFLLLAIADTPAMLFIHKIPTIF 127
Cdd:TIGR00711 281 YLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQF 356
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
47-119 |
9.30e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 37.89 E-value: 9.30e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348533784 47 FSVTpYLAKKLGFDTLWFGYLQTTVGVIQLLGGPMFGRFADLFGARTALSLACASTVV----FFLLLAIADTPAMLF 119
Cdd:cd17369 250 FALS-YATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALfafpFFWLLDTGSTWLIVL 325
|
|
| |
