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Conserved domains on  [gi|347966499|ref|XP_003435920|]
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AGAP001751-PD [Anopheles gambiae str. PEST]

Protein Classification

TLD domain-containing protein( domain architecture ID 10651862)

TLD domain-containing protein similar to Homo sapiens MTOR-associated protein MEAK7 that activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration

PubMed:  26668325|28707022

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
50-212 2.30e-74

domain in TBC and LysM domain containing proteins;


:

Pssm-ID: 214733  Cd Length: 165  Bit Score: 221.81  E-value: 2.30e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499    50 TEILSEEHREKLCAHLPARAEGYSWSLVFSTSQHGFSLNSLYRKMHKLESPILIVIEDTDHNVFGALTSCSLHVSDHFYG 129
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499   130 TGESLLYKFNPHFKVFHWSGENL-YFIKGNPESLAIGAGDGKFGLWLDGDLNQGRSQHCSTYSNEPL-APQEDFVIKTLE 207
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNKyYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLsTKQEDFLILDIE 160

                   ....*
gi 347966499   208 CWAFV 212
Cdd:smart00584 161 VWGFG 165
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
50-212 2.30e-74

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 221.81  E-value: 2.30e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499    50 TEILSEEHREKLCAHLPARAEGYSWSLVFSTSQHGFSLNSLYRKMHKLESPILIVIEDTDHNVFGALTSCSLHVSDHFYG 129
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499   130 TGESLLYKFNPHFKVFHWSGENL-YFIKGNPESLAIGAGDGKFGLWLDGDLNQGRSQHCSTYSNEPL-APQEDFVIKTLE 207
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNKyYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLsTKQEDFLILDIE 160

                   ....*
gi 347966499   208 CWAFV 212
Cdd:smart00584 161 VWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
76-212 2.04e-44

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 144.67  E-value: 2.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499   76 LVFSTSQHGFSLNSLYRKMhKLESPILIVIEDTDHNVFGALTSCSLHVSDH-FYGTGESLLYKFNPHFKVFHWSGENLYF 154
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKI-DNKGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAY 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499  155 IKGNPESLAIGAGDGKFGLWLDGDLNQGRSQHCSTYSNEPLAP--QEDFVIKTLECWAFV 212
Cdd:pfam07534  80 FNCTSDGLGFGGGQPKFDLWIDSDLEFGYSRHCETFGNGQLSGsgQERFKIDDVEVWGLG 139
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
52-209 8.01e-30

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 109.60  E-value: 8.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499  52 ILSEEHREKLCAHLPARAEGY-SWSLVFSTSQHGFSLNSLYRKMHKLESPI-----LIVIEDTDHNVFGALTSCSLHVSD 125
Cdd:COG5142   36 LLTEEIVTRIRESLPDRYKYStSWRLLYSLFENGFSLRTFYESFGENEWPFrrvgfVLACRDKDGDLFGAFFEDRIRPAR 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499 126 HFYGTGESLLYKFNP---------HFKVFHWSGENLYFIKGNPESLAIGAGDGKFGLWLDGDLNQGRSQHCSTYSNEPLA 196
Cdd:COG5142  116 HYYGRDEMFLWKAARrpadrladkEVAVYPISGGKGFGIYCTPDFLAFGCGGGRYGLLIDKSLLDGESHPVETFGNCLLS 195
                        170
                 ....*....|....
gi 347966499 197 PQEDFV-IKTLECW 209
Cdd:COG5142  196 SKGHFFrIVYLELW 209
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
50-212 2.30e-74

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 221.81  E-value: 2.30e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499    50 TEILSEEHREKLCAHLPARAEGYSWSLVFSTSQHGFSLNSLYRKMHKLESPILIVIEDTDHNVFGALTSCSLHVSDHFYG 129
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499   130 TGESLLYKFNPHFKVFHWSGENL-YFIKGNPESLAIGAGDGKFGLWLDGDLNQGRSQHCSTYSNEPL-APQEDFVIKTLE 207
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNKyYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLsTKQEDFLILDIE 160

                   ....*
gi 347966499   208 CWAFV 212
Cdd:smart00584 161 VWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
76-212 2.04e-44

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 144.67  E-value: 2.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499   76 LVFSTSQHGFSLNSLYRKMhKLESPILIVIEDTDHNVFGALTSCSLHVSDH-FYGTGESLLYKFNPHFKVFHWSGENLYF 154
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKI-DNKGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAY 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499  155 IKGNPESLAIGAGDGKFGLWLDGDLNQGRSQHCSTYSNEPLAP--QEDFVIKTLECWAFV 212
Cdd:pfam07534  80 FNCTSDGLGFGGGQPKFDLWIDSDLEFGYSRHCETFGNGQLSGsgQERFKIDDVEVWGLG 139
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
52-209 8.01e-30

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 109.60  E-value: 8.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499  52 ILSEEHREKLCAHLPARAEGY-SWSLVFSTSQHGFSLNSLYRKMHKLESPI-----LIVIEDTDHNVFGALTSCSLHVSD 125
Cdd:COG5142   36 LLTEEIVTRIRESLPDRYKYStSWRLLYSLFENGFSLRTFYESFGENEWPFrrvgfVLACRDKDGDLFGAFFEDRIRPAR 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347966499 126 HFYGTGESLLYKFNP---------HFKVFHWSGENLYFIKGNPESLAIGAGDGKFGLWLDGDLNQGRSQHCSTYSNEPLA 196
Cdd:COG5142  116 HYYGRDEMFLWKAARrpadrladkEVAVYPISGGKGFGIYCTPDFLAFGCGGGRYGLLIDKSLLDGESHPVETFGNCLLS 195
                        170
                 ....*....|....
gi 347966499 197 PQEDFV-IKTLECW 209
Cdd:COG5142  196 SKGHFFrIVYLELW 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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