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Conserved domains on  [gi|339236149|ref|XP_003379629|]
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gastrulation defective protein 1 [Trichinella spiralis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-430 7.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 7.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 108 SKPVSAFAFDGSGARFASGGYDYSVSLWDFAGMDasMKSFRSLHPFECHVINQTGDSILAVSGSA--QAKILDRDGRELI 185
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSdkTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 186 ECVKGdqyivdmsktkgHIAQLNGGCWHPTSRnEFITCSDDGTVRVWDycTAKKSQSAVIKTKTKSGqrtvpTCCTFSRD 265
Cdd:cd00200   87 RTLTG------------HTSYVSSVAFSPDGR-ILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWV-----NSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 266 GKLVAAGCNDGSIQMWQhgklyVNTAKLIRDAHnnGHD--ITSLSFSYDDVNLLSRSMDGSLKLWDVRLLKHpLHVAEGL 343
Cdd:cd00200  147 GTFVASSSQDGTIKLWD-----LRTGKCVATLT--GHTgeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGH 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 344 ENmfPSTDCLFSPRNEYCLTGTtlkRQGHCvgdlVIFEKNSFKEVNRIEYPKEasiiyislGVIRVAWHPRINQIFCGTT 423
Cdd:cd00200  219 EN--GVNSVAFSPDGYLLASGS---EDGTI----RVWDLRTGECVQTLSGHTN--------SVTSLAWSPDGKRLASGSA 281


                 ....*..
gi 339236149 424 SGKIRIY 430
Cdd:cd00200  282 DGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-430 7.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 7.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 108 SKPVSAFAFDGSGARFASGGYDYSVSLWDFAGMDasMKSFRSLHPFECHVINQTGDSILAVSGSA--QAKILDRDGRELI 185
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSdkTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 186 ECVKGdqyivdmsktkgHIAQLNGGCWHPTSRnEFITCSDDGTVRVWDycTAKKSQSAVIKTKTKSGqrtvpTCCTFSRD 265
Cdd:cd00200   87 RTLTG------------HTSYVSSVAFSPDGR-ILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWV-----NSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 266 GKLVAAGCNDGSIQMWQhgklyVNTAKLIRDAHnnGHD--ITSLSFSYDDVNLLSRSMDGSLKLWDVRLLKHpLHVAEGL 343
Cdd:cd00200  147 GTFVASSSQDGTIKLWD-----LRTGKCVATLT--GHTgeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGH 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 344 ENmfPSTDCLFSPRNEYCLTGTtlkRQGHCvgdlVIFEKNSFKEVNRIEYPKEasiiyislGVIRVAWHPRINQIFCGTT 423
Cdd:cd00200  219 EN--GVNSVAFSPDGYLLASGS---EDGTI----RVWDLRTGECVQTLSGHTN--------SVTSLAWSPDGKRLASGSA 281


                 ....*..
gi 339236149 424 SGKIRIY 430
Cdd:cd00200  282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
108-364 3.99e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 3.99e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 108 SKPVSAFAFDGSGARFASGGYDYSVSLWDFAgmdasmkSFRSLHPFECH-------VINQTGDSILAVSGSAQAKILDRD 180
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLA-------TGKLLRTLTGHsgavtsvAFSPDGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 181 GRELIEcvkgdqyivdmsKTKGHIAQLNGGCWHPTSRNeFITCSDDGTVRVWDYctakKSQSAViktKTKSGQRTVPTCC 260
Cdd:COG2319  193 TGKLLR------------TLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDL----ATGKLL---RTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 261 TFSRDGKLVAAGCNDGSIQMWQhgklyVNTAKLIRDAHNNGHDITSLSFSYDDVNLLSRSMDGSLKLWDVRLLKhPLHVA 340
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTL 326

                        250       260
                 ....*....|....*....|....
gi 339236149 341 EGLENMFPSTDclFSPRNEYCLTG 364
Cdd:COG2319  327 TGHTGAVRSVA--FSPDGKTLASG 348
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 101-346 2.20e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 101 EAEVNHGSKPVSAFAFDGSGARFASGGYDYSVSLwdfagmdasmksfrslhpFEChvinqtgDSILavsgsaqakildRD 180
Cdd:PLN00181 476 QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKI------------------FEC-------ESII------------KD 518

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 181 GRELiecvkgdQY-IVDMSKTkghiAQLNGGCWHPTSRNEFITCSDDGTVRVWDyctAKKSQsavIKTKTKSGQRTVPTC 259
Cdd:PLN00181 519 GRDI-------HYpVVELASR----SKLSGICWNSYIKSQVASSNFEGVVQVWD---VARSQ---LVTEMKEHEKRVWSI 581

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 260 CTFSRDGKLVAAGCNDGSIQMWQHGK-LYVNTAKL------IRDAHNNGHDIT--------------------------S 306
Cdd:PLN00181 582 DYSSADPTLLASGSDDGSVKLWSINQgVSIGTIKTkaniccVQFPSESGRSLAfgsadhkvyyydlrnpklplctmighS 661

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 339236149 307 LSFSY----DDVNLLSRSMDGSLKLWDVRLL-----KHPLHVAEGLENM 346
Cdd:PLN00181 662 KTVSYvrfvDSSTLVSSSTDNTLKLWDLSMSisginETPLHSFMGHTNV 710
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-233 5.33e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 5.33e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 339236149   201 KGHIAQLNGGCWHPTSrNEFITCSDDGTVRVWD 233
Cdd:smart00320   9 KGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
201-233 9.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.19e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 339236149  201 KGHIAQLNGGCWHPTSRNeFITCSDDGTVRVWD 233
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-430 7.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 7.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 108 SKPVSAFAFDGSGARFASGGYDYSVSLWDFAGMDasMKSFRSLHPFECHVINQTGDSILAVSGSA--QAKILDRDGRELI 185
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSdkTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 186 ECVKGdqyivdmsktkgHIAQLNGGCWHPTSRnEFITCSDDGTVRVWDycTAKKSQSAVIKTKTKSGqrtvpTCCTFSRD 265
Cdd:cd00200   87 RTLTG------------HTSYVSSVAFSPDGR-ILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWV-----NSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 266 GKLVAAGCNDGSIQMWQhgklyVNTAKLIRDAHnnGHD--ITSLSFSYDDVNLLSRSMDGSLKLWDVRLLKHpLHVAEGL 343
Cdd:cd00200  147 GTFVASSSQDGTIKLWD-----LRTGKCVATLT--GHTgeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGH 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 344 ENmfPSTDCLFSPRNEYCLTGTtlkRQGHCvgdlVIFEKNSFKEVNRIEYPKEasiiyislGVIRVAWHPRINQIFCGTT 423
Cdd:cd00200  219 EN--GVNSVAFSPDGYLLASGS---EDGTI----RVWDLRTGECVQTLSGHTN--------SVTSLAWSPDGKRLASGSA 281


                 ....*..
gi 339236149 424 SGKIRIY 430
Cdd:cd00200  282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
108-364 3.99e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 3.99e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 108 SKPVSAFAFDGSGARFASGGYDYSVSLWDFAgmdasmkSFRSLHPFECH-------VINQTGDSILAVSGSAQAKILDRD 180
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLA-------TGKLLRTLTGHsgavtsvAFSPDGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 181 GRELIEcvkgdqyivdmsKTKGHIAQLNGGCWHPTSRNeFITCSDDGTVRVWDYctakKSQSAViktKTKSGQRTVPTCC 260
Cdd:COG2319  193 TGKLLR------------TLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDL----ATGKLL---RTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 261 TFSRDGKLVAAGCNDGSIQMWQhgklyVNTAKLIRDAHNNGHDITSLSFSYDDVNLLSRSMDGSLKLWDVRLLKhPLHVA 340
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTL 326

                        250       260
                 ....*....|....*....|....
gi 339236149 341 EGLENMFPSTDclFSPRNEYCLTG 364
Cdd:COG2319  327 TGHTGAVRSVA--FSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
102-364 2.20e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 2.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 102 AEVNHGSKPVSAFAFDGSGARFASGGYDYSVSLWDFAgmdasmkSFRSLHPFECH-------VINQTGDSILAVSGSAQA 174
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLTGHtgavrsvAFSPDGKLLASGSADGTV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 175 KILDRDGRELIecvkgdqyivdmSKTKGHIAQLNGGCWHPTSRnEFITCSDDGTVRVWDYCTAKKsqsavikTKTKSGQR 254
Cdd:COG2319  229 RLWDLATGKLL------------RTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-------LRTLTGHS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 255 TVPTCCTFSRDGKLVAAGCNDGSIQMWQhgklyVNTAKLIRDAHNNGHDITSLSFSYDDVNLLSRSMDGSLKLWDVRLLK 334
Cdd:COG2319  289 GGVNSVAFSPDGKLLASGSDDGTVRLWD-----LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                        250       260       270
                 ....*....|....*....|....*....|
gi 339236149 335 hPLHVAEGLENmfPSTDCLFSPRNEYCLTG 364
Cdd:COG2319  364 -LLRTLTGHTG--AVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
102-430 6.58e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 6.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 102 AEVNHGSKPVSAFAFDGSGARFASGGYDYSVSLWDFAGMdasmksfRSLHPFECH-------VINQTGDSILAVSGSAQA 174
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-------LLLRTLTGHtgavrsvAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 175 KILDRDGRELIecvkgdqyivdmsKT-KGHIAQLNGGCWHPTSRNeFITCSDDGTVRVWDYCTAKksqsaviKTKTKSGQ 253
Cdd:COG2319  145 RLWDLATGKLL-------------RTlTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGK-------LLRTLTGH 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 254 RTVPTCCTFSRDGKLVAAGCNDGSIQMWQhgklyVNTAKLIRDAHNNGHDITSLSFSYDDVNLLSRSMDGSLKLWDV--- 330
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADGTVRLWD-----LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLatg 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 331 ---RLLKHPLHVAEGLEnmfpstdclFSPRNEYCLTGT---TLKrqghcvgdlvIFEKNSFKEVNRIEYPKEAsiiyisl 404
Cdd:COG2319  279 ellRTLTGHSGGVNSVA---------FSPDGKLLASGSddgTVR----------LWDLATGKLLRTLTGHTGA------- 332

                        330       340
                 ....*....|....*....|....*.
gi 339236149 405 gVIRVAWHPRINQIFCGTTSGKIRIY 430
Cdd:COG2319  333 -VRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-329 1.63e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 1.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 108 SKPVSAFAFDGSGARFASGGYDYSVSLWDFAgmdaSMKSFRSLHPFECHV----INQTGDSILAVSGSAQAKILDRDGRE 183
Cdd:cd00200   51 TGPVRDVAASADGTYLASGSSDKTIRLWDLE----TGECVRTLTGHTSYVssvaFSPDGRILSSSSRDKTIKVWDVETGK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 184 LIECVKG-------------DQYIV-----------DMSKTK------GHIAQLNGGCWHPTSrNEFITCSDDGTVRVWD 233
Cdd:cd00200  127 CLTTLRGhtdwvnsvafspdGTFVAsssqdgtiklwDLRTGKcvatltGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 234 ycTAKKSQSAVIKTKTKSgqrtvPTCCTFSRDGKLVAAGCNDGSIQMWQhgklyVNTAKLIRD--AHNNGhdITSLSFSY 311
Cdd:cd00200  206 --LSTGKCLGTLRGHENG-----VNSVAFSPDGYLLASGSEDGTIRVWD-----LRTGECVQTlsGHTNS--VTSLAWSP 271

                        250
                 ....*....|....*...
gi 339236149 312 DDVNLLSRSMDGSLKLWD 329
Cdd:cd00200  272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
106-430 7.41e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 7.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 106 HGSKPVSAFAFDGSGARFASGGYDYSVSLWDFAGMDASMKSFRSLHPFECHVINQTGDSILAVSGSAQAKILDRDGRELI 185
Cdd:COG2319   34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 186 ecvkgdqyivdmSKTKGHIAQLNGGCWHPTSRnEFITCSDDGTVRVWDYCTAKKSQsaviktkTKSGQRTVPTCCTFSRD 265
Cdd:COG2319  114 ------------RTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLATGKLLR-------TLTGHSGAVTSVAFSPD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 266 GKLVAAGCNDGSIQMWQhgklyVNTAKLIR--DAHNNGhdITSLSFSYDDVNLLSRSMDGSLKLWDVRLLKhPLHVAEGL 343
Cdd:COG2319  174 GKLLASGSDDGTVRLWD-----LATGKLLRtlTGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGH 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 344 ENmfPSTDCLFSPRNEYCLTGT---TLKrqghcvgdlvIFEKNSFKEVNRIEYPKEasiiyislGVIRVAWHPRINQIFC 420
Cdd:COG2319  246 SG--SVRSVAFSPDGRLLASGSadgTVR----------LWDLATGELLRTLTGHSG--------GVNSVAFSPDGKLLAS 305

                        330
                 ....*....|
gi 339236149 421 GTTSGKIRIY 430
Cdd:COG2319  306 GSDDGTVRLW 315
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 101-346 2.20e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 101 EAEVNHGSKPVSAFAFDGSGARFASGGYDYSVSLwdfagmdasmksfrslhpFEChvinqtgDSILavsgsaqakildRD 180
Cdd:PLN00181 476 QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKI------------------FEC-------ESII------------KD 518

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 181 GRELiecvkgdQY-IVDMSKTkghiAQLNGGCWHPTSRNEFITCSDDGTVRVWDyctAKKSQsavIKTKTKSGQRTVPTC 259
Cdd:PLN00181 519 GRDI-------HYpVVELASR----SKLSGICWNSYIKSQVASSNFEGVVQVWD---VARSQ---LVTEMKEHEKRVWSI 581

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 260 CTFSRDGKLVAAGCNDGSIQMWQHGK-LYVNTAKL------IRDAHNNGHDIT--------------------------S 306
Cdd:PLN00181 582 DYSSADPTLLASGSDDGSVKLWSINQgVSIGTIKTkaniccVQFPSESGRSLAfgsadhkvyyydlrnpklplctmighS 661

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 339236149 307 LSFSY----DDVNLLSRSMDGSLKLWDVRLL-----KHPLHVAEGLENM 346
Cdd:PLN00181 662 KTVSYvrfvDSSTLVSSSTDNTLKLWDLSMSisginETPLHSFMGHTNV 710
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-233 5.33e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 5.33e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 339236149   201 KGHIAQLNGGCWHPTSrNEFITCSDDGTVRVWD 233
Cdd:smart00320   9 KGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
201-233 9.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.19e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 339236149  201 KGHIAQLNGGCWHPTSRNeFITCSDDGTVRVWD 233
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 258-281 2.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 2.09e-03
                           10        20
                   ....*....|....*....|....
gi 339236149   258 TCCTFSRDGKLVAAGCNDGSIQMW 281
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
258-281 3.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.15e-03
                          10        20
                  ....*....|....*....|....
gi 339236149  258 TCCTFSRDGKLVAAGCNDGSIQMW 281
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 290-329 3.26e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 339236149   290 TAKLIRDAHNNGHDITSLSFSYDDVNLLSRSMDGSLKLWD 329
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
300-329 3.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.40e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 339236149  300 NGHD--ITSLSFSYDDVNLLSRSMDGSLKLWD 329
Cdd:pfam00400   8 EGHTgsVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-136 3.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 3.78e-03
                           10        20
                   ....*....|....*....|....*....
gi 339236149   108 SKPVSAFAFDGSGARFASGGYDYSVSLWD 136
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 201-337 6.40e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 6.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236149 201 KGHIAQLNGGCWHPTsrNEFITCSD--DGTVRVWDYCTAKKSQSAVIKTKTKSGQRTVptcctfsrDGKLVAAGCNDGSI 278
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLKWNI--------KGNLLSGTCVGKHM 191

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 339236149 279 QMWQHGKLYVNTAKLIRDAHNNGHDITSLSFSYDDVNLLSRSMDGS----LKLWDVRLLKHPL 337
Cdd:PTZ00420 192 HIIDPRKQEIASSFHIHDGGKNTKNIWIDGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSAL 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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