rap guanine nucleotide exchange factor 5 isoform X1 [Nomascus leucogenys]
guanine nucleotide exchange factor( domain architecture ID 10858405)
Ras guanine nucleotide exchange factor activates Ras-like small GTPases by mediating the replacement of GDP with GTP
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
RasGEF | smart00147 | Guanine nucleotide exchange factor for Ras-like small GTPases; |
644-883 | 1.52e-86 | |||||
Guanine nucleotide exchange factor for Ras-like small GTPases; : Pssm-ID: 214539 Cd Length: 242 Bit Score: 276.05 E-value: 1.52e-86
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DEP_Epac | cd04437 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange ... |
103-225 | 5.47e-60 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization. : Pssm-ID: 239884 Cd Length: 125 Bit Score: 199.88 E-value: 5.47e-60
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RasGEFN | smart00229 | Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
372-503 | 2.88e-27 | |||||
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343). : Pssm-ID: 214571 Cd Length: 127 Bit Score: 107.42 E-value: 2.88e-27
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Name | Accession | Description | Interval | E-value | |||||
RasGEF | smart00147 | Guanine nucleotide exchange factor for Ras-like small GTPases; |
644-883 | 1.52e-86 | |||||
Guanine nucleotide exchange factor for Ras-like small GTPases; Pssm-ID: 214539 Cd Length: 242 Bit Score: 276.05 E-value: 1.52e-86
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RasGEF | cd00155 | Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ... |
644-878 | 1.94e-81 | |||||
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors. Pssm-ID: 238087 [Multi-domain] Cd Length: 237 Bit Score: 262.19 E-value: 1.94e-81
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RasGEF | pfam00617 | RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. |
651-828 | 1.17e-68 | |||||
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. Pssm-ID: 459872 Cd Length: 179 Bit Score: 225.55 E-value: 1.17e-68
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DEP_Epac | cd04437 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange ... |
103-225 | 5.47e-60 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization. Pssm-ID: 239884 Cd Length: 125 Bit Score: 199.88 E-value: 5.47e-60
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RasGEFN | smart00229 | Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
372-503 | 2.88e-27 | |||||
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343). Pssm-ID: 214571 Cd Length: 127 Bit Score: 107.42 E-value: 2.88e-27
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REM | cd06224 | Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ... |
379-502 | 3.08e-19 | |||||
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few. Pssm-ID: 100121 Cd Length: 122 Bit Score: 84.39 E-value: 3.08e-19
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
119-186 | 1.44e-14 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 69.15 E-value: 1.44e-14
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RasGEF_N | pfam00618 | RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ... |
374-461 | 7.91e-12 | |||||
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain. Pssm-ID: 459873 Cd Length: 104 Bit Score: 62.32 E-value: 7.91e-12
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
119-188 | 8.54e-10 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 55.75 E-value: 8.54e-10
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Name | Accession | Description | Interval | E-value | |||||
RasGEF | smart00147 | Guanine nucleotide exchange factor for Ras-like small GTPases; |
644-883 | 1.52e-86 | |||||
Guanine nucleotide exchange factor for Ras-like small GTPases; Pssm-ID: 214539 Cd Length: 242 Bit Score: 276.05 E-value: 1.52e-86
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RasGEF | cd00155 | Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ... |
644-878 | 1.94e-81 | |||||
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors. Pssm-ID: 238087 [Multi-domain] Cd Length: 237 Bit Score: 262.19 E-value: 1.94e-81
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RasGEF | pfam00617 | RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. |
651-828 | 1.17e-68 | |||||
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. Pssm-ID: 459872 Cd Length: 179 Bit Score: 225.55 E-value: 1.17e-68
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DEP_Epac | cd04437 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange ... |
103-225 | 5.47e-60 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization. Pssm-ID: 239884 Cd Length: 125 Bit Score: 199.88 E-value: 5.47e-60
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RasGEFN | smart00229 | Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
372-503 | 2.88e-27 | |||||
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343). Pssm-ID: 214571 Cd Length: 127 Bit Score: 107.42 E-value: 2.88e-27
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REM | cd06224 | Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ... |
379-502 | 3.08e-19 | |||||
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few. Pssm-ID: 100121 Cd Length: 122 Bit Score: 84.39 E-value: 3.08e-19
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DEP | cd04371 | DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ... |
105-185 | 5.56e-15 | |||||
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction. Pssm-ID: 239836 Cd Length: 81 Bit Score: 70.83 E-value: 5.56e-15
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
119-186 | 1.44e-14 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 69.15 E-value: 1.44e-14
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RasGEF_N | pfam00618 | RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ... |
374-461 | 7.91e-12 | |||||
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain. Pssm-ID: 459873 Cd Length: 104 Bit Score: 62.32 E-value: 7.91e-12
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
119-188 | 8.54e-10 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 55.75 E-value: 8.54e-10
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DEP_1_DEP6 | cd04442 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ... |
103-186 | 3.40e-08 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown. Pssm-ID: 239889 [Multi-domain] Cd Length: 82 Bit Score: 51.43 E-value: 3.40e-08
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DEP_2_DEP6 | cd04441 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins ... |
104-186 | 6.94e-06 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown. Pssm-ID: 239888 Cd Length: 85 Bit Score: 45.12 E-value: 6.94e-06
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DEP_DEPDC5-like | cd04449 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ... |
114-186 | 3.55e-05 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function. Pssm-ID: 239896 Cd Length: 83 Bit Score: 43.03 E-value: 3.55e-05
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DEP_PIKfyve | cd04448 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange ... |
129-185 | 6.34e-05 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol phosphate kinase) domain. PIKfyve-like proteins are important phosphatidylinositol (3)-monophosphate (PtdIns(3)P)-5-kinases, producing PtdIns(3,5)P2, which plays a major role in multivesicular body (MVB) sorting and control of retrograde traffic from the vacuole back to the endosome and/or Golgi. PIKfyve itself has been shown to be play a role in regulating early-endosome-to-trans-Golgi network (TGN) retrograde trafficking. Pssm-ID: 239895 Cd Length: 81 Bit Score: 42.04 E-value: 6.34e-05
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DEP_GPR155 | cd04443 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like ... |
116-186 | 3.88e-04 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the class B G protein-coupled receptors. Their function is unknown. Pssm-ID: 239890 [Multi-domain] Cd Length: 83 Bit Score: 40.01 E-value: 3.88e-04
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