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Conserved domains on  [gi|2445347107|ref|XP_003091523|]
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hypothetical protein GCK72_000160 [Caenorhabditis remanei]

Protein Classification

prefoldin subunit 6( domain architecture ID 19227319)

prefoldin subunit 6 (PFDN6) is a beta subunit of prefoldin, a hexameric co-chaperone prefoldin complex that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly

Gene Ontology:  GO:0016272|GO:0061077|GO:0051082|GO:0003714
PubMed:  9630229|11106732|33137104

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 5.73e-31

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


:

Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 106.03  E-value: 5.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107  11 VNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKRVEA 90
Cdd:cd23161     1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                          90       100
                  ....*....|....*....|.
gi 2445347107  91 SIADVTKKSSDQRDKVMNIQK 111
Cdd:cd23161    81 QIKDLEKKQEKKREKIAKLQQ 101
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 5.73e-31

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 106.03  E-value: 5.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107  11 VNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKRVEA 90
Cdd:cd23161     1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                          90       100
                  ....*....|....*....|.
gi 2445347107  91 SIADVTKKSSDQRDKVMNIQK 111
Cdd:cd23161    81 QIKDLEKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 11-111 3.41e-12

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 58.39  E-value: 3.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107  11 VNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKRVEA 90
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEK 80

                          90       100
                  ....*....|....*....|.
gi 2445347107  91 SIADVTKKSSDQRDKVMNIQK 111
Cdd:pfam01920  81 QLEKLEKELEELKEELYKKFG 101
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
8-106 5.68e-05

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 39.87  E-value: 5.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107   8 EEEVNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKR 87
Cdd:COG1382    10 QNQLAQLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRLKT 89

                          90
                  ....*....|....*....
gi 2445347107  88 VEASIADVTKKSSDQRDKV 106
Cdd:COG1382    90 LEKQEERLQKQLEELQEKL 108
PRK09343 PRK09343
prefoldin subunit beta; Provisional
 10-98 2.27e-03

prefoldin subunit beta; Provisional


Pssm-ID: 181787 [Multi-domain]  Cd Length: 121  Bit Score: 35.43  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107  10 EVNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVR-------QELEEARSTVEKRLEFIE 82
Cdd:PRK09343   12 QLAQLQQLQQQLERLLQQKSQIDLELREINKALEELEKLPDDTPIYKIVGNLLVKvdktkveKELKERKELLELRSRTLE 91

                          90
                  ....*....|....*.
gi 2445347107  83 SEIKRVEASIADVTKK 98
Cdd:PRK09343   92 KQEKKLREKLKELQAK 107
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 5.73e-31

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 106.03  E-value: 5.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107  11 VNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKRVEA 90
Cdd:cd23161     1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                          90       100
                  ....*....|....*....|.
gi 2445347107  91 SIADVTKKSSDQRDKVMNIQK 111
Cdd:cd23161    81 QIKDLEKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 11-111 3.41e-12

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 58.39  E-value: 3.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107  11 VNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKRVEA 90
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEK 80

                          90       100
                  ....*....|....*....|.
gi 2445347107  91 SIADVTKKSSDQRDKVMNIQK 111
Cdd:pfam01920  81 QLEKLEKELEELKEELYKKFG 101
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
8-106 5.68e-05

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 39.87  E-value: 5.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107   8 EEEVNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKR 87
Cdd:COG1382    10 QNQLAQLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRLKT 89

                          90
                  ....*....|....*....
gi 2445347107  88 VEASIADVTKKSSDQRDKV 106
Cdd:COG1382    90 LEKQEERLQKQLEELQEKL 108
Prefoldin_beta cd00632
Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, ...
 26-89 8.67e-05

Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467469  Cd Length: 78  Bit Score: 38.48  E-value: 8.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2445347107  26 SSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKRVE 89
Cdd:cd00632     7 SQKEELERKINEQKVVLDELSNLKKNRKVYRQQGNIFILASKEETLSELKKTLDHLQKEIKELE 70
Prefoldin_beta_GimC cd23162
Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric ...
 28-98 4.76e-04

Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467478 [Multi-domain]  Cd Length: 102  Bit Score: 36.69  E-value: 4.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2445347107  28 RQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVR-------QELEEARSTVEKRLEFIESEIKRVEASIADVTKK 98
Cdd:cd23162    20 KQQLEAELREIERALEELEKLPDDAEVYKSVGTILVKvdkeeviKELKERKETLELRLKTLEKQEERLRKQLEELQKK 97
PRK09343 PRK09343
prefoldin subunit beta; Provisional
 10-98 2.27e-03

prefoldin subunit beta; Provisional


Pssm-ID: 181787 [Multi-domain]  Cd Length: 121  Bit Score: 35.43  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107  10 EVNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVR-------QELEEARSTVEKRLEFIE 82
Cdd:PRK09343   12 QLAQLQQLQQQLERLLQQKSQIDLELREINKALEELEKLPDDTPIYKIVGNLLVKvdktkveKELKERKELLELRSRTLE 91

                          90
                  ....*....|....*.
gi 2445347107  83 SEIKRVEASIADVTKK 98
Cdd:PRK09343   92 KQEKKLREKLKELQAK 107
Prefoldin_2 cd23163
prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic ...
 9-105 4.39e-03

prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467479  Cd Length: 100  Bit Score: 34.41  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2445347107   9 EEVNKLKTLEKDREKYFSSRQEMEMRLTESRNVKAELDLMDTDSKVYKLIGAVLVRQELEEARSTVEKRLEFIESEIKRV 88
Cdd:cd23163     1 EVVAQYNQLRQEQQQLASKIAELEQELNEHKLVIDTLKPLDPDRKCFRLVGGVLVERTVGEVLPALEENKENLEEVIEQL 80

                          90
                  ....*....|....*..
gi 2445347107  89 EASIADVTKKSSDQRDK 105
Cdd:cd23163    81 NEQLEEKEKELNEFREK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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