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Conserved domains on  [gi|302784092|ref|XP_002973818|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 [Selaginella moellendorffii]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1772 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3276.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   11 DAVAEPRLGLPKLIGAALDRIVKNTSWRGHGKLVQECKAAQERLNAPSAKENgnSTAAAAAAAAAAAGLESSKFHarafe 90
Cdd:PLN03076    1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNPP--STSSAAADSASASSLPGPLHD----- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   91 sflfDGPVCYNASSAELILQPLVTACDSQSAKLADPALDCIQKLIAHGHLRGEVDAESGSEFLVLVQMMDNVCKCHELGD 170
Cdd:PLN03076   74 ----GGSIEYSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHDLGD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  171 EQIELLVLKTLLTAVTSTTLRVHGDCLLKAVRTCYNVFLGSKAPVNQTTAKASLTQMLVIVFRRMEADSSTVPVQPIVVT 250
Cdd:PLN03076  150 EGIELLVLKTLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  251 DLMEPAERSSSDTNTTQFVQSFITKVVQDIEVALSPATSFKSL---KHDGAFESTAATENSGSSDFLESTDRDMLDAKYW 327
Cdd:PLN03076  230 ELMEPAEKSDSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSgsgAHDGAFETTATVETTNPADLLDSTDKDMLDAKYW 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  328 EVSMYKNALEGKRGEFADADLDKDGDLDVQITNKLRRDAFLVFRALCKLSMKVAPQEAM-DNVSLRGKILALELLKLLLE 406
Cdd:PLN03076  310 EISMYKSALEGRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALaDPQLMRGKILALELLKILLE 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  407 NAGAVFRTSDRFVGAIRQYLCLSLLRNSGIQLMNIFQLSCSIFMSLLLRFRAGLKAEVGVFFPPIVLRVLENVAQPNYQQ 486
Cdd:PLN03076  390 NAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQ 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  487 KMIVIRFLDKLCVDPQVLVDLFVNYDCDVDSHNIFERLVNGLLKTAQGVPPGVESSLTPIQDAAMKLAAMKSLVGVLRSM 566
Cdd:PLN03076  470 KMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSM 549

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  567 GDWANRQLRLSDAAYLRSLDQTDSTSESNS--VGHNGFEENGDGAESrVSEISSETSEVATFEQRRAYKLEFQEGISLFN 644
Cdd:PLN03076  550 GDWMNKQLRLPDPASLKKLDAVENNLEPGSlpVANGNGDENGEGSDS-HSELSSETSDAATIEQRRAYKLELQEGISLFN 628

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  645 RKPSKGIQFLINAKKIGDSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQGMEFDEAIRIFLQGFRL 724
Cdd:PLN03076  629 RKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRL 708

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  725 PGEAQKIDRIMEKFAERYCKCNPKAFTSADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMKNNRGIDDGNDLPEEFMSA 804
Cdd:PLN03076  709 PGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRS 788

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  805 LYDRIVKCEIKMKADSLVPTNKP---TNRILGIESILNIVIRRPKEDRLQETSDDIIKNMQQQLKEKAGKSGSVYYSPSD 881
Cdd:PLN03076  789 LYERISKNEIKMKEDDLVPQQKQsanSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATD 868

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  882 VEILRPMVEVTWAPMLAAFSVPLEKSEDEVITFQCLEGFRYAIRVTSIMSMRTERDAFVTSLAKFTYLHSPADIKQKNID 961
Cdd:PLN03076  869 VVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNID 948

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  962 SIKAVISIADEDGNYLQEAWEHVLTCVSRFEHLHLIGEGAPPDATFFAAPQSDSDKTMQLKSPVLPVLKRKWPGRMQYAA 1041
Cdd:PLN03076  949 AIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAA 1028

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1042 AAARRGSYESAGVGGNSAGSVTAEQMNNLVSNLNMLEQIGSFEMNKIFTRSDRLNGEAIVDFVKALCKVSMEELRSPTDP 1121
Cdd:PLN03076 1029 AAVRRGSYDSAGVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDP 1108

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1122 RVFSLTKIVEISHFNMNRIRLVWSRIWNVLSDYFVTVGCSDNLSIAMYAMDSLRQLAMKFLEREELANYNFQNQFLKPFV 1201
Cdd:PLN03076 1109 RVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFV 1188

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1202 VVMRKSNSVEIRELVIRCVSQMVFARVKNVKSGWKIMFMVFTTAATDEHKSMVLLAFETIEKIVREYFSFITETETTTFT 1281
Cdd:PLN03076 1189 IVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFT 1268

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1282 DCVNCLIAFTNSRFNNDISLNAIAFLRFCAHKLAEGELGAYVKKEDRVAN---------GDMSEPTFTDRDDDLHFWFPL 1352
Cdd:PLN03076 1269 DCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPpsspqsgkdGKQESGEFTDKDDHLYFWFPL 1348

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1353 LAGLSELTFDPRPEIRKSALEVLFDILRSHGHMFSPALWERVFDSVLLPLFDYVRRAIEPLQAAED-------DHPEFEM 1425
Cdd:PLN03076 1349 LAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPegqgvdgDQGELDQ 1428

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1426 DAWLYETCTLALQLVVDLFVKFYPVVAHLLGRILLLLTGFLKRPHQSLAAIGVAAFVRLMSHTGHLFTDEKWDEVLAALQ 1505
Cdd:PLN03076 1429 DAWLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLK 1508

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1506 EAAEGTLPDMSKVM-------ECLEDIELQKAIQGYKTENDAMAEEMTRLQAALSDYKCRTAVQLLLVQAVNELFTNHGS 1578
Cdd:PLN03076 1509 EAANATLPDFSYVVsgeympaENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRP 1588

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1579 RLAASHSMLLLDTLHVVAAHAHNVNSDIALRTKLQQVKVATQLSDPPLLRLESESYHAYLNLLQTLSVLKPELAKDAEVE 1658
Cdd:PLN03076 1589 RLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVE 1668

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1659 GRLVELCEEVLQVYLCTATgvaAAWDSGDKSSAQPLWSIPLSSSRRRELSARAPLVVSTLQAVGGLKESSFEKHLLRFFP 1738
Cdd:PLN03076 1669 SRLVELCEEVLQFYIETST---AGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFP 1745

                        1770      1780      1790
                  ....*....|....*....|....*....|....
gi 302784092 1739 LLATLIACEHGSEEVQVALSDMFSSWIGPILLQA 1772
Cdd:PLN03076 1746 LLAGLISCEHGSNEVQVALSDMLSSWVGPVLLQS 1779
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1772 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3276.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   11 DAVAEPRLGLPKLIGAALDRIVKNTSWRGHGKLVQECKAAQERLNAPSAKENgnSTAAAAAAAAAAAGLESSKFHarafe 90
Cdd:PLN03076    1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNPP--STSSAAADSASASSLPGPLHD----- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   91 sflfDGPVCYNASSAELILQPLVTACDSQSAKLADPALDCIQKLIAHGHLRGEVDAESGSEFLVLVQMMDNVCKCHELGD 170
Cdd:PLN03076   74 ----GGSIEYSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHDLGD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  171 EQIELLVLKTLLTAVTSTTLRVHGDCLLKAVRTCYNVFLGSKAPVNQTTAKASLTQMLVIVFRRMEADSSTVPVQPIVVT 250
Cdd:PLN03076  150 EGIELLVLKTLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  251 DLMEPAERSSSDTNTTQFVQSFITKVVQDIEVALSPATSFKSL---KHDGAFESTAATENSGSSDFLESTDRDMLDAKYW 327
Cdd:PLN03076  230 ELMEPAEKSDSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSgsgAHDGAFETTATVETTNPADLLDSTDKDMLDAKYW 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  328 EVSMYKNALEGKRGEFADADLDKDGDLDVQITNKLRRDAFLVFRALCKLSMKVAPQEAM-DNVSLRGKILALELLKLLLE 406
Cdd:PLN03076  310 EISMYKSALEGRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALaDPQLMRGKILALELLKILLE 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  407 NAGAVFRTSDRFVGAIRQYLCLSLLRNSGIQLMNIFQLSCSIFMSLLLRFRAGLKAEVGVFFPPIVLRVLENVAQPNYQQ 486
Cdd:PLN03076  390 NAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQ 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  487 KMIVIRFLDKLCVDPQVLVDLFVNYDCDVDSHNIFERLVNGLLKTAQGVPPGVESSLTPIQDAAMKLAAMKSLVGVLRSM 566
Cdd:PLN03076  470 KMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSM 549

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  567 GDWANRQLRLSDAAYLRSLDQTDSTSESNS--VGHNGFEENGDGAESrVSEISSETSEVATFEQRRAYKLEFQEGISLFN 644
Cdd:PLN03076  550 GDWMNKQLRLPDPASLKKLDAVENNLEPGSlpVANGNGDENGEGSDS-HSELSSETSDAATIEQRRAYKLELQEGISLFN 628

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  645 RKPSKGIQFLINAKKIGDSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQGMEFDEAIRIFLQGFRL 724
Cdd:PLN03076  629 RKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRL 708

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  725 PGEAQKIDRIMEKFAERYCKCNPKAFTSADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMKNNRGIDDGNDLPEEFMSA 804
Cdd:PLN03076  709 PGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRS 788

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  805 LYDRIVKCEIKMKADSLVPTNKP---TNRILGIESILNIVIRRPKEDRLQETSDDIIKNMQQQLKEKAGKSGSVYYSPSD 881
Cdd:PLN03076  789 LYERISKNEIKMKEDDLVPQQKQsanSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATD 868

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  882 VEILRPMVEVTWAPMLAAFSVPLEKSEDEVITFQCLEGFRYAIRVTSIMSMRTERDAFVTSLAKFTYLHSPADIKQKNID 961
Cdd:PLN03076  869 VVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNID 948

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  962 SIKAVISIADEDGNYLQEAWEHVLTCVSRFEHLHLIGEGAPPDATFFAAPQSDSDKTMQLKSPVLPVLKRKWPGRMQYAA 1041
Cdd:PLN03076  949 AIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAA 1028

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1042 AAARRGSYESAGVGGNSAGSVTAEQMNNLVSNLNMLEQIGSFEMNKIFTRSDRLNGEAIVDFVKALCKVSMEELRSPTDP 1121
Cdd:PLN03076 1029 AAVRRGSYDSAGVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDP 1108

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1122 RVFSLTKIVEISHFNMNRIRLVWSRIWNVLSDYFVTVGCSDNLSIAMYAMDSLRQLAMKFLEREELANYNFQNQFLKPFV 1201
Cdd:PLN03076 1109 RVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFV 1188

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1202 VVMRKSNSVEIRELVIRCVSQMVFARVKNVKSGWKIMFMVFTTAATDEHKSMVLLAFETIEKIVREYFSFITETETTTFT 1281
Cdd:PLN03076 1189 IVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFT 1268

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1282 DCVNCLIAFTNSRFNNDISLNAIAFLRFCAHKLAEGELGAYVKKEDRVAN---------GDMSEPTFTDRDDDLHFWFPL 1352
Cdd:PLN03076 1269 DCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPpsspqsgkdGKQESGEFTDKDDHLYFWFPL 1348

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1353 LAGLSELTFDPRPEIRKSALEVLFDILRSHGHMFSPALWERVFDSVLLPLFDYVRRAIEPLQAAED-------DHPEFEM 1425
Cdd:PLN03076 1349 LAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPegqgvdgDQGELDQ 1428

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1426 DAWLYETCTLALQLVVDLFVKFYPVVAHLLGRILLLLTGFLKRPHQSLAAIGVAAFVRLMSHTGHLFTDEKWDEVLAALQ 1505
Cdd:PLN03076 1429 DAWLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLK 1508

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1506 EAAEGTLPDMSKVM-------ECLEDIELQKAIQGYKTENDAMAEEMTRLQAALSDYKCRTAVQLLLVQAVNELFTNHGS 1578
Cdd:PLN03076 1509 EAANATLPDFSYVVsgeympaENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRP 1588

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1579 RLAASHSMLLLDTLHVVAAHAHNVNSDIALRTKLQQVKVATQLSDPPLLRLESESYHAYLNLLQTLSVLKPELAKDAEVE 1658
Cdd:PLN03076 1589 RLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVE 1668

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1659 GRLVELCEEVLQVYLCTATgvaAAWDSGDKSSAQPLWSIPLSSSRRRELSARAPLVVSTLQAVGGLKESSFEKHLLRFFP 1738
Cdd:PLN03076 1669 SRLVELCEEVLQFYIETST---AGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFP 1745

                        1770      1780      1790
                  ....*....|....*....|....*....|....
gi 302784092 1739 LLATLIACEHGSEEVQVALSDMFSSWIGPILLQA 1772
Cdd:PLN03076 1746 LLAGLISCEHGSNEVQVALSDMLSSWVGPVLLQS 1779
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 633-814 1.24e-99

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 317.48  E-value: 1.24e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   633 KLEFQEGISLFNRKPSKGIQFLINAKKIGDSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQGMEFD 712
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   713 EAIRIFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFTSADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMKNNRGID 792
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 302784092   793 DGNDLPEEFMSALYDRIVKCEI 814
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 632-814 1.16e-87

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 283.34  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  632 YKLEFQEGISLFNRKPSKGIQFLINAKKI-GDSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQGME 710
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  711 FDEAIRIFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFT-SADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMKNNR 789
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*
gi 302784092  790 GIDDGNDLPEEFMSALYDRIVKCEI 814
Cdd:cd00171   161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 630-814 1.31e-78

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 257.60  E-value: 1.31e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092    630 RAYKLEFQEGISLFNRKPSKGIQFLINAKKIG-DSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQG 708
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092    709 MEFDEAIRIFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFT--SADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMK 786
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 302784092    787 NNRGIDDGNDLPEEFMSALYDRIVKCEI 814
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1772 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3276.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   11 DAVAEPRLGLPKLIGAALDRIVKNTSWRGHGKLVQECKAAQERLNAPSAKENgnSTAAAAAAAAAAAGLESSKFHarafe 90
Cdd:PLN03076    1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNPP--STSSAAADSASASSLPGPLHD----- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   91 sflfDGPVCYNASSAELILQPLVTACDSQSAKLADPALDCIQKLIAHGHLRGEVDAESGSEFLVLVQMMDNVCKCHELGD 170
Cdd:PLN03076   74 ----GGSIEYSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHDLGD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  171 EQIELLVLKTLLTAVTSTTLRVHGDCLLKAVRTCYNVFLGSKAPVNQTTAKASLTQMLVIVFRRMEADSSTVPVQPIVVT 250
Cdd:PLN03076  150 EGIELLVLKTLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  251 DLMEPAERSSSDTNTTQFVQSFITKVVQDIEVALSPATSFKSL---KHDGAFESTAATENSGSSDFLESTDRDMLDAKYW 327
Cdd:PLN03076  230 ELMEPAEKSDSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSgsgAHDGAFETTATVETTNPADLLDSTDKDMLDAKYW 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  328 EVSMYKNALEGKRGEFADADLDKDGDLDVQITNKLRRDAFLVFRALCKLSMKVAPQEAM-DNVSLRGKILALELLKLLLE 406
Cdd:PLN03076  310 EISMYKSALEGRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALaDPQLMRGKILALELLKILLE 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  407 NAGAVFRTSDRFVGAIRQYLCLSLLRNSGIQLMNIFQLSCSIFMSLLLRFRAGLKAEVGVFFPPIVLRVLENVAQPNYQQ 486
Cdd:PLN03076  390 NAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQ 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  487 KMIVIRFLDKLCVDPQVLVDLFVNYDCDVDSHNIFERLVNGLLKTAQGVPPGVESSLTPIQDAAMKLAAMKSLVGVLRSM 566
Cdd:PLN03076  470 KMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSM 549

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  567 GDWANRQLRLSDAAYLRSLDQTDSTSESNS--VGHNGFEENGDGAESrVSEISSETSEVATFEQRRAYKLEFQEGISLFN 644
Cdd:PLN03076  550 GDWMNKQLRLPDPASLKKLDAVENNLEPGSlpVANGNGDENGEGSDS-HSELSSETSDAATIEQRRAYKLELQEGISLFN 628

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  645 RKPSKGIQFLINAKKIGDSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQGMEFDEAIRIFLQGFRL 724
Cdd:PLN03076  629 RKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRL 708

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  725 PGEAQKIDRIMEKFAERYCKCNPKAFTSADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMKNNRGIDDGNDLPEEFMSA 804
Cdd:PLN03076  709 PGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRS 788

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  805 LYDRIVKCEIKMKADSLVPTNKP---TNRILGIESILNIVIRRPKEDRLQETSDDIIKNMQQQLKEKAGKSGSVYYSPSD 881
Cdd:PLN03076  789 LYERISKNEIKMKEDDLVPQQKQsanSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATD 868

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  882 VEILRPMVEVTWAPMLAAFSVPLEKSEDEVITFQCLEGFRYAIRVTSIMSMRTERDAFVTSLAKFTYLHSPADIKQKNID 961
Cdd:PLN03076  869 VVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNID 948

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  962 SIKAVISIADEDGNYLQEAWEHVLTCVSRFEHLHLIGEGAPPDATFFAAPQSDSDKTMQLKSPVLPVLKRKWPGRMQYAA 1041
Cdd:PLN03076  949 AIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAA 1028

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1042 AAARRGSYESAGVGGNSAGSVTAEQMNNLVSNLNMLEQIGSFEMNKIFTRSDRLNGEAIVDFVKALCKVSMEELRSPTDP 1121
Cdd:PLN03076 1029 AAVRRGSYDSAGVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDP 1108

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1122 RVFSLTKIVEISHFNMNRIRLVWSRIWNVLSDYFVTVGCSDNLSIAMYAMDSLRQLAMKFLEREELANYNFQNQFLKPFV 1201
Cdd:PLN03076 1109 RVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFV 1188

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1202 VVMRKSNSVEIRELVIRCVSQMVFARVKNVKSGWKIMFMVFTTAATDEHKSMVLLAFETIEKIVREYFSFITETETTTFT 1281
Cdd:PLN03076 1189 IVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFT 1268

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1282 DCVNCLIAFTNSRFNNDISLNAIAFLRFCAHKLAEGELGAYVKKEDRVAN---------GDMSEPTFTDRDDDLHFWFPL 1352
Cdd:PLN03076 1269 DCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPpsspqsgkdGKQESGEFTDKDDHLYFWFPL 1348

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1353 LAGLSELTFDPRPEIRKSALEVLFDILRSHGHMFSPALWERVFDSVLLPLFDYVRRAIEPLQAAED-------DHPEFEM 1425
Cdd:PLN03076 1349 LAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPegqgvdgDQGELDQ 1428

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1426 DAWLYETCTLALQLVVDLFVKFYPVVAHLLGRILLLLTGFLKRPHQSLAAIGVAAFVRLMSHTGHLFTDEKWDEVLAALQ 1505
Cdd:PLN03076 1429 DAWLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLK 1508

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1506 EAAEGTLPDMSKVM-------ECLEDIELQKAIQGYKTENDAMAEEMTRLQAALSDYKCRTAVQLLLVQAVNELFTNHGS 1578
Cdd:PLN03076 1509 EAANATLPDFSYVVsgeympaENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRP 1588

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1579 RLAASHSMLLLDTLHVVAAHAHNVNSDIALRTKLQQVKVATQLSDPPLLRLESESYHAYLNLLQTLSVLKPELAKDAEVE 1658
Cdd:PLN03076 1589 RLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVE 1668

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092 1659 GRLVELCEEVLQVYLCTATgvaAAWDSGDKSSAQPLWSIPLSSSRRRELSARAPLVVSTLQAVGGLKESSFEKHLLRFFP 1738
Cdd:PLN03076 1669 SRLVELCEEVLQFYIETST---AGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFP 1745

                        1770      1780      1790
                  ....*....|....*....|....*....|....
gi 302784092 1739 LLATLIACEHGSEEVQVALSDMFSSWIGPILLQA 1772
Cdd:PLN03076 1746 LLAGLISCEHGSNEVQVALSDMLSSWVGPVLLQS 1779
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 633-814 1.24e-99

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 317.48  E-value: 1.24e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   633 KLEFQEGISLFNRKPSKGIQFLINAKKIGDSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQGMEFD 712
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   713 EAIRIFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFTSADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMKNNRGID 792
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 302784092   793 DGNDLPEEFMSALYDRIVKCEI 814
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 632-814 1.16e-87

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 283.34  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  632 YKLEFQEGISLFNRKPSKGIQFLINAKKI-GDSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQGME 710
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  711 FDEAIRIFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFT-SADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMKNNR 789
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*
gi 302784092  790 GIDDGNDLPEEFMSALYDRIVKCEI 814
Cdd:cd00171   161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 630-814 1.31e-78

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 257.60  E-value: 1.31e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092    630 RAYKLEFQEGISLFNRKPSKGIQFLINAKKIG-DSPKEIAGFLLSSTGLDKTVIGDYLGENDELPLKVMHAYVDSFNFQG 708
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092    709 MEFDEAIRIFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFT--SADTAYVLAYSVILLNTDAHNPMVKSKMTKAEFMK 786
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 302784092    787 NNRGIDDGNDLPEEFMSALYDRIVKCEI 814
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1560-1762 8.52e-41

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 148.93  E-value: 8.52e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  1560 AVQLLLVQAVNELFTNHGSRLAASHSMLLLDTLHVVAAHAHNVNSDIALRTKLQQVKVATQLsdPPLLRLESESYHAYLN 1639
Cdd:pfam20252    1 VVQLLLIQTVNEILDEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLELRTALWRAGFMKQL--PNLLKQETSSLSTYLR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  1640 LLQTL-SVLKPELAKDAEVEGRLVELCEEVLQVYLCTATgvaaawdsgdkssaqplwsiplsSSRRRELSARAPLVVSTL 1718
Cdd:pfam20252   79 ILFRLyADDEPRTSQREEVEERLIPLCEDILEYYLSLDE-----------------------EEKQRELAAWTPVVVLIL 135

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 302784092  1719 QAVGGLKESSFEKHLLRFFPLLATLIACEhGSEEVQVALSDMFS 1762
Cdd:pfam20252  136 QGLLALPDDDFRRHLPEFYPLLCDLILCE-LSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 362-516 1.76e-40

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 147.26  E-value: 1.76e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   362 LRRDAFLVFRALCKLS-MKVAPQEAMDNVSLRGKILALELLKLLLENAGAVFRTSDRFVGAIRQYLCLSLLRNSGIQLMN 440
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSKSDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSSFP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302784092   441 IFQLSCSIFMSLLLRFRAGLKAEVGVFFPPIVLRVLENVAqpNYQQKMIVIRFLDKLCVDPQVLVDLFVNYDCDVD 516
Cdd:pfam12783   81 VFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLESDS--SLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1180-1263 3.87e-36

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 131.84  E-value: 3.87e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  1180 KFLEREELANYNFQNQFLKPFVVVMRKSNSVEIRELVIRCVSQMVFARVKNVKSGWKIMFMVFTTAATDEHKSMVLLAFE 1259
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ....
gi 302784092  1260 TIEK 1263
Cdd:pfam09324   81 ILEL 84
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 30-235 1.36e-35

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 133.92  E-value: 1.36e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092    30 RIVKNTSWRGHGKLVQECKAAQERLNAPSAKENGNSTAaaaaaaaaaaglesskfharafesflfdgpvcynASSAELIL 109
Cdd:pfam16213   14 RTLSSEAKRKYPPVKEASEKGILRLRTVHSSSPLMQNL----------------------------------LSASEDIL 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092   110 QPLVTACDSQSAKLADPALDCIQKLIAHGHLRGEvdaesgseflVLVQMMDNVCKCHELGDEqIELLVLKTLLTAVTsTT 189
Cdd:pfam16213   60 KPFVLACETKNPKLVQIALGCLQKLISHDAISQS----------AAPYILDTLWMLMELGSE-IELKVLQTVLLLIT-TN 127

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 302784092   190 LRVHGDCLLKAVRTCYNVFLgSKAPVNQTTAKASLTQMLVIVFRRM 235
Cdd:pfam16213  128 SVIHGDTLAKALVLCFRLHF-SKDPTVQNTASATLRQLVSVVFERV 172
Mon2_C pfam16206
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
 1348-1407 9.15e-10

C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.


Pssm-ID: 465066  Cd Length: 827  Bit Score: 63.60  E-value: 9.15e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302784092  1348 FWFPLLAGLSELTFDPRPEIRKSALEVLFDILRSHGHMFSPALWERVFDSVLLPLFDYVR 1407
Cdd:pfam16206   92 LWLCLYAKLGELCVDLRPAVRKSAGQTLFSTIGAHGSLLNHPTWHALIWKVLFNLLDNVR 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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