F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 847092100  809 WLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWKII 852
Cdd:cd22139     1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 847092100  809 WLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWKII 852
Cdd:cd22139     1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100  924 FHASSYCRKLTSVDISWTA-ATDNGVITLIDSSPQVQNLSVNGC-KITDHAITALvqkhskslvklevfgchaltarclc 1001
Cdd:cd09293    45 LDQLSNCNKLKKLILPGSKlIDDEGLIALAQSCPNLQVLDLRACeNITDSGIVAL------------------------- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1002 tvATECVYLQCLNIGRLPK---FTDVCLAKIASSLNKLTTLNVTGLNVVrDRSVHHIVKQCLK-LENLTLSSCSQVTDVS 1077
Cdd:cd09293   100 --ATNCPKLQTINLGRHRNghlITDVSLSALGKNCTFLQTVGFAGCDVT-DKGVWELASGCSKsLERLSLNNCRNLTDQS 176

                         170       180
                  ....*....|....*....|....*.
gi 847092100 1078 LVEI--STYLPTIKYLDVSGCKKVSD 1101
Cdd:cd09293   177 IPAIlaSNYFPNLSVLEFRGCPLITD 202

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1026 LAKIASSLNKLTTLNVTGlNVVRDRSVHHIVKQcLK----LENLTLSsCSQVTDVSLVEISTYL---PTIKYLDVSGcKK 1098
Cdd:COG5238   228 LAEALKGNKSLTTLDLSN-NQIGDEGVIALAEA-LKnnttVETLYLS-GNQIGAEGAIALAKALqgnTTLTSLDLSV-NR 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1099 VSDIGIQALARSCKQINH---LDLSSTGVGKRGVCLLASYCYA--SLECLKLSFCK--DVTADAIEKLCKNCKRLKMLHL 1171
Cdd:COG5238   304 IGDEGAIALAEGLQGNKTlhtLNLAYNGIGAQGAIALAKALQEntTLHSLDLSDNQigDEGAIALAKYLEGNTTLRELNL 383

                  ....*...
gi 847092100 1172 YGCRISPD 1179
Cdd:COG5238   384 GKNNIGKQ 391

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 847092100  809 WLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWKII 852
Cdd:cd22139     1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100  924 FHASSYCRKLTSVDISWTA-ATDNGVITLIDSSPQVQNLSVNGC-KITDHAITALvqkhskslvklevfgchaltarclc 1001
Cdd:cd09293    45 LDQLSNCNKLKKLILPGSKlIDDEGLIALAQSCPNLQVLDLRACeNITDSGIVAL------------------------- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1002 tvATECVYLQCLNIGRLPK---FTDVCLAKIASSLNKLTTLNVTGLNVVrDRSVHHIVKQCLK-LENLTLSSCSQVTDVS 1077
Cdd:cd09293   100 --ATNCPKLQTINLGRHRNghlITDVSLSALGKNCTFLQTVGFAGCDVT-DKGVWELASGCSKsLERLSLNNCRNLTDQS 176

                         170       180
                  ....*....|....*....|....*.
gi 847092100 1078 LVEI--STYLPTIKYLDVSGCKKVSD 1101
Cdd:cd09293   177 IPAIlaSNYFPNLSVLEFRGCPLITD 202

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 847092100  809 WLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22132     1 WPLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWK 42

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 847092100  809 WLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLW 849
Cdd:cd22114     1 WDSLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 847092100  809 WLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22149     1 FERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 847092100  810 LLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWKIIE 853
Cdd:cd20090     3 LDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIA 46

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 847092100  810 LLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22102     2 LDLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQ 42

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 847092100  810 LLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22122     2 HVLPREVWLPVFQYLSPKDLCVCMRVCKTWNRWCCDPSLWK 42

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 847092100  811 LLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLW 849
Cdd:cd22151     2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLW 40

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 847092100  811 LLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22147     4 ALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWK 43

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 847092100  812 LPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLW 849
Cdd:cd22118     4 LPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 847092100  811 LLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWKII 852
Cdd:cd22120     3 RLPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 847092100  808 MWLLLPDELWIFIFSKLPHKD-LSKAAQVC---RRFChiaNDDSLWKIIE 853
Cdd:cd22164     1 NWLDLPDDLTASILSRLGAIDiLTNAQKVCklwRRIC---KDPSMWRVID 47

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100  870 HHHPESLKLnhchdSGQCITDEGLRQLFQNCKDFlKELKITNVSG------PRFAGDAIlfHASSYCRKLTSVDISWTAA 943
Cdd:cd00116    22 LLCLQVLRL-----EGNTLGEEAAKALASALRPQ-PSLKELCLSLnetgriPRGLQSLL--QGLTKGCGLQELDLSDNAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100  944 TDNGVITLID--SSPQVQNLSVNGCKITDhAITALVQKHSKSLV-KLEVFGChaltARCLCTVATecvylqclnigrlpk 1020
Cdd:cd00116    94 GPDGCGVLESllRSSSLQELKLNNNGLGD-RGLRLLAKGLKDLPpALEKLVL----GRNRLEGAS--------------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1021 ftdvC--LAKIASSLNKLTTLNVtGLNVVRDRSVHHIVK----QClKLENLTLSSCsqvtdvslveistylptikyldvs 1094
Cdd:cd00116   154 ----CeaLAKALRANRDLKELNL-ANNGIGDAGIRALAEglkaNC-NLEVLDLNNN------------------------ 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1095 gckKVSDIGIQALA---RSCKQINHLDLSSTGVGKRGVCLLASYCYASLECLK---LSFCkDVTADAIEKLCKNCK---R 1165
Cdd:cd00116   204 ---GLTDEGASALAetlASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLtlsLSCN-DITDDGAKDLAEVLAekeS 279

                         330
                  ....*....|....*..
gi 847092100 1166 LKMLHLYGCRISPDLDY 1182
Cdd:cd00116   280 LLELDLRGNKFGEEGAQ 296

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 847092100  810 LLLPDELWIFIFS--KLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22096     2 LELPDELLEYILCsdNLDHHDIIRLSCTCRRLREVCQSGKVWR 44

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 847092100  812 LPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWKII 852
Cdd:cd22093     4 LPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 847092100  809 WLLLPDELWIFIF----SKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22089     3 ISALPSEILLYILrwvvSDLDLRSLEQLSLVCRKFYLLARDPSIWR 48

F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 847092100  809 WLLLPDELWIFIFSKLPHKD-LSKAAQVCRRFCHIANDDSLWKI 851
Cdd:cd22135     1 LLSLPPELLLHICSYLDARFvLHVLPLVCKTFRDILSDETTWRI 44

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1026 LAKIASSLNKLTTLNVTGlNVVRDRSVHHIVKQcLK----LENLTLSsCSQVTDVSLVEISTYL---PTIKYLDVSGcKK 1098
Cdd:COG5238   228 LAEALKGNKSLTTLDLSN-NQIGDEGVIALAEA-LKnnttVETLYLS-GNQIGAEGAIALAKALqgnTTLTSLDLSV-NR 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847092100 1099 VSDIGIQALARSCKQINH---LDLSSTGVGKRGVCLLASYCYA--SLECLKLSFCK--DVTADAIEKLCKNCKRLKMLHL 1171
Cdd:COG5238   304 IGDEGAIALAEGLQGNKTlhtLNLAYNGIGAQGAIALAKALQEntTLHSLDLSDNQigDEGAIALAKYLEGNTTLRELNL 383

                  ....*...
gi 847092100 1172 YGCRISPD 1179
Cdd:COG5238   384 GKNNIGKQ 391

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 847092100  807 DMWLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22094     1 DFTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWL 44

F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called FBX39, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a cancer/testis antigen from colon cancer patients by serological analysis of recombinant cDNA expression libraries (SEREX). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 847092100  809 WLLLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22108     1 WANLPDVCLRHVFRWLGDRDRSRAALVCKRWNQAMYSPALWR 42

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 847092100  812 LPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDS 847
Cdd:cd22157     3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38

Leucine-rich repeat - CC (cysteine-containing) subfamily;

                            10        20
                    ....*....|....*....|....
gi 847092100   1059 CLKLENLTLSSCSQVTDVSLVEIS 1082
Cdd:smart00367    1 CPNLRELDLSGCTNITDEGLQALA 24

F-box domain found in F-box/LRR-repeat protein 10 (FBXL10) and similar proteins; FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10, F-box protein FBL10, JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 847092100  811 LLPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLW 849
Cdd:cd22180     5 VMQREVWMAVFSYLSHRDLCVCMRVCRTWNRWCCDKRLW 43

Leucine-rich repeat - CC (cysteine-containing) subfamily;

                            10        20
                    ....*....|....*....|...
gi 847092100   1088 IKYLDVSGCKKVSDIGIQALARS 1110
Cdd:smart00367    4 LRELDLSGCTNITDEGLQALAKG 26

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 847092100  812 LPDELWIFIFSKLPHKDLSKAAQVCRRFCHIANDDSLWK 850
Cdd:cd22166     4 LPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWR 42