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Conserved domains on  [gi|255731404|ref|XP_002550626|]
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3-isopropylmalate dehydrogenase [Candida tropicalis MYA-3404]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
8-363 3.48e-171

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00169:

Pssm-ID: 444908  Cd Length: 346  Bit Score: 480.75  E-value: 3.48e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404    8 ITVLPGDHVGTEIVAEAIKSLKAIESNtpyQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGPKWGT 87
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAER---FGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   88 G--SVRPEQGLLKIRKELNLYANIRPCNFAsDSLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDgktAWDT 165
Cdd:TIGR00169  79 LprDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGE---AWDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  166 EKYTVDEVTRITRMAAFMALQHNPplPIWSLDKANVLASSRLWRRTVDKVIsEEFPTLKVQHQLIDSAAMILIQNPTKLN 245
Cdd:TIGR00169 155 EVYTVPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIA-KEYPDVELEHQYIDNAAMQLVKSPTQFD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  246 gIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLSLDC 324
Cdd:TIGR00169 232 -VVVTSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNL 305

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 255731404  325 VKEAEALEKAVQEVLDKGIRTADLrGTSTTTEVGDAVAE 363
Cdd:TIGR00169 306 EEAADAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMG 343
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 8-363 3.48e-171

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 480.75  E-value: 3.48e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404    8 ITVLPGDHVGTEIVAEAIKSLKAIESNtpyQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGPKWGT 87
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAER---FGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   88 G--SVRPEQGLLKIRKELNLYANIRPCNFAsDSLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDgktAWDT 165
Cdd:TIGR00169  79 LprDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGE---AWDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  166 EKYTVDEVTRITRMAAFMALQHNPplPIWSLDKANVLASSRLWRRTVDKVIsEEFPTLKVQHQLIDSAAMILIQNPTKLN 245
Cdd:TIGR00169 155 EVYTVPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIA-KEYPDVELEHQYIDNAAMQLVKSPTQFD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  246 gIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLSLDC 324
Cdd:TIGR00169 232 -VVVTSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNL 305

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 255731404  325 VKEAEALEKAVQEVLDKGIRTADLrGTSTTTEVGDAVAE 363
Cdd:TIGR00169 306 EEAADAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMG 343
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 4-367 1.39e-162

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 459.57  E-value: 1.39e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   4 KTKTITVLPGDHVGTEIVAEAIKSLKAIESNtpyQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGP 83
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEK---FGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  84 KWGT--GSVRPEQGLLKIRKELNLYANIRPCNFAsDSLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDGKT 161
Cdd:PRK00772  78 KWDNlpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEER 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 162 AWDTEKYTVDEVTRITRMAAFMALQHNPPLPiwSLDKANVLASSRLWRRTVDKViSEEFPTLKVQHQLIDSAAMILIQNP 241
Cdd:PRK00772 157 AFDTMVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTEV-AKEYPDVELSHMYVDNAAMQLVRNP 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 242 TKLnGIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRL 320
Cdd:PRK00772 234 KQF-DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRY 307

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 255731404 321 SLDCVKEAEALEKAVQEVLDKGIRTADLR---GTSTTTEVGDAVAEAVAR 367
Cdd:PRK00772 308 SLGLEEAADAIEAAVEKVLAQGYRTADIAeggGKVSTSEMGDAILAALAE 357
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
7-361 7.45e-156

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 442.12  E-value: 7.45e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404    7 TITVLPGDHVGTEIVAEAIKSLKAIESNTPyqkIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGPKWG 86
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAP---LEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   87 TGSVRPEQGLLKIRKELNLYANIRPCNFASdsLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESkDGKTAWDTE 166
Cdd:pfam00180  78 PAGVRPENGLLALRKELGLFANLRPAKVFP--PLGDASPLKNEVEGVDIVIVRELTGGIYFGIEKGIKGS-GNEVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  167 KYTVDEVTRITRMAAFMALQHNPPlPIWSLDKANVLASSRLWRRTVDKVISEEFPTLKVQHQLIDSAAMILIQNPtKLNG 246
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNP-SQFD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  247 IIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLSLDCV 325
Cdd:pfam00180 233 VIVTPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLE 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 255731404  326 KEAEALEKAVQEVLDKGIRTADLRGTST---TTEVGDAV 361
Cdd:pfam00180 308 DAADKIEAAVLKVLESGIRTGDLAGSATyvsTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 5-365 6.96e-150

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 426.74  E-value: 6.96e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   5 TKTITVLPGDHVGTEIVAEAIKSLKAIESNTpyqKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGPK 84
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERF---GLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  85 WGTGsVRPEQGLLKIRKELNLYANIRPC-NFASdsllELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDGKTAW 163
Cdd:COG0473   78 WDDG-VRPESGLLALRKELDLYANLRPAkLYPG----LPSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 164 DTEKYTVDEVTRITRMAAFMALQHNPPLpiWSLDKANVLA-SSRLWRRTVDKViSEEFPTLKVQHQLIDSAAMILIQNPT 242
Cdd:COG0473  153 DTRVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVREV-AKEYPDVELDHMYVDAAAMQLVRNPE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 243 KLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLs 321
Cdd:COG0473  230 QFD-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH- 302

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 255731404 322 LDCVKEAEALEKAVQEVLDKGIRTADLRGTSTTTEVGDAVAEAV 365
Cdd:COG0473  303 LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 8-363 3.48e-171

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 480.75  E-value: 3.48e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404    8 ITVLPGDHVGTEIVAEAIKSLKAIESNtpyQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGPKWGT 87
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAER---FGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   88 G--SVRPEQGLLKIRKELNLYANIRPCNFAsDSLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDgktAWDT 165
Cdd:TIGR00169  79 LprDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGE---AWDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  166 EKYTVDEVTRITRMAAFMALQHNPplPIWSLDKANVLASSRLWRRTVDKVIsEEFPTLKVQHQLIDSAAMILIQNPTKLN 245
Cdd:TIGR00169 155 EVYTVPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIA-KEYPDVELEHQYIDNAAMQLVKSPTQFD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  246 gIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLSLDC 324
Cdd:TIGR00169 232 -VVVTSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNL 305

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 255731404  325 VKEAEALEKAVQEVLDKGIRTADLrGTSTTTEVGDAVAE 363
Cdd:TIGR00169 306 EEAADAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMG 343
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 4-367 1.39e-162

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 459.57  E-value: 1.39e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   4 KTKTITVLPGDHVGTEIVAEAIKSLKAIESNtpyQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGP 83
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEK---FGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  84 KWGT--GSVRPEQGLLKIRKELNLYANIRPCNFAsDSLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDGKT 161
Cdd:PRK00772  78 KWDNlpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEER 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 162 AWDTEKYTVDEVTRITRMAAFMALQHNPPLPiwSLDKANVLASSRLWRRTVDKViSEEFPTLKVQHQLIDSAAMILIQNP 241
Cdd:PRK00772 157 AFDTMVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTEV-AKEYPDVELSHMYVDNAAMQLVRNP 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 242 TKLnGIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRL 320
Cdd:PRK00772 234 KQF-DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRY 307

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 255731404 321 SLDCVKEAEALEKAVQEVLDKGIRTADLR---GTSTTTEVGDAVAEAVAR 367
Cdd:PRK00772 308 SLGLEEAADAIEAAVEKVLAQGYRTADIAeggGKVSTSEMGDAILAALAE 357
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
7-361 7.45e-156

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 442.12  E-value: 7.45e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404    7 TITVLPGDHVGTEIVAEAIKSLKAIESNTPyqkIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGPKWG 86
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAP---LEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   87 TGSVRPEQGLLKIRKELNLYANIRPCNFASdsLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESkDGKTAWDTE 166
Cdd:pfam00180  78 PAGVRPENGLLALRKELGLFANLRPAKVFP--PLGDASPLKNEVEGVDIVIVRELTGGIYFGIEKGIKGS-GNEVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  167 KYTVDEVTRITRMAAFMALQHNPPlPIWSLDKANVLASSRLWRRTVDKVISEEFPTLKVQHQLIDSAAMILIQNPtKLNG 246
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNP-SQFD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  247 IIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLSLDCV 325
Cdd:pfam00180 233 VIVTPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLE 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 255731404  326 KEAEALEKAVQEVLDKGIRTADLRGTST---TTEVGDAV 361
Cdd:pfam00180 308 DAADKIEAAVLKVLESGIRTGDLAGSATyvsTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 5-365 6.96e-150

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 426.74  E-value: 6.96e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   5 TKTITVLPGDHVGTEIVAEAIKSLKAIESNTpyqKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGPK 84
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERF---GLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  85 WGTGsVRPEQGLLKIRKELNLYANIRPC-NFASdsllELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDGKTAW 163
Cdd:COG0473   78 WDDG-VRPESGLLALRKELDLYANLRPAkLYPG----LPSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 164 DTEKYTVDEVTRITRMAAFMALQHNPPLpiWSLDKANVLA-SSRLWRRTVDKViSEEFPTLKVQHQLIDSAAMILIQNPT 242
Cdd:COG0473  153 DTRVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVREV-AKEYPDVELDHMYVDAAAMQLVRNPE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 243 KLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLs 321
Cdd:COG0473  230 QFD-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH- 302

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 255731404 322 LDCVKEAEALEKAVQEVLDKGIRTADLRGTSTTTEVGDAVAEAV 365
Cdd:COG0473  303 LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 4-365 2.49e-82

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 256.92  E-value: 2.49e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   4 KTKTITVLPGDHVGTEIVAEAIKSLKAIESntpYQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGP 83
Cdd:PLN02329  45 KRYNIALLPGDGIGPEVISVAKNVLQKAGS---LEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  84 KWGTGS--VRPEQGLLKIRKELNLYANIRPCNFASDsLLELSPLSSEVVKGTNLIIVRELVGGIYFGEREEQEESKDG-K 160
Cdd:PLN02329 122 KWDKNEkhLRPEMALFYLRRDLKVFANLRPATVLPQ-LVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGeE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 161 TAWDTEKYTVDEVTRITRMAAFMALQHNPPLpiWSLDKANVLASSRLWRRTVDKVISeEFPTLKVQHQLIDSAAMILIQN 240
Cdd:PLN02329 201 VGVSTEIYAAHEIDRIARVAFETARKRRGKL--CSVDKANVLDASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLIRD 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 241 PTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtnTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLR 319
Cdd:PLN02329 278 PKQFD-TIVTNNIFGDILSDEASMITGSIGMLPSASLGE-----SGPGLFEPIHGSAPDIAgQDKANPLATILSAAMLLK 351

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 255731404 320 LSLDCVKEAEALEKAVQEVLDKGIRTADLRGTSTT----TEVGDAVAEAV 365
Cdd:PLN02329 352 YGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKlvgcKEMGEEVLKSV 401
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 6-365 6.80e-67

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 214.61  E-value: 6.80e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   6 KTITVLPGDHVGTEIVAEAIKSLKAIEsntpyqkIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGgpkw 85
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATG-------LPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG---- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  86 gtgsVRPEQGLLKIRKELNLYANIRPcnfasdslLELSPLSSEVVKGTNLIIVRELVGGIYFGereEQEESKDGKTAwDT 165
Cdd:PRK14025  71 ----ETAADVIVKLRRILDTYANVRP--------VKSYKGVKCLYPDIDYVIVRENTEGLYKG---IEAEIADGVTV-AT 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 166 EKYTVDEVTRITRMAAFMALQHNPPL---PIWSLDKANVLA-SSRLWRRTVDKViSEEFPTLKVQHQLIDSAAMILIQNP 241
Cdd:PRK14025 135 RVITRKASERIFRFAFEMAKRRKKMGkegKVTCAHKANVLKkTDGLFKKTFYEV-AKEYPDIKAEDYYVDAMNMYIITRP 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 242 TKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtntAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRl 320
Cdd:PRK14025 214 QTFD-VVVTSNLFGDILSDGAAGLVGGLGLAPSANIGD------KYGLFEPVHGSAPDIAgKGIANPTATILTAVLMLR- 285

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 255731404 321 SLDCVKEAEALEKAVQEVLDKGIRTADLRGTSTTTEVGDAVAEAV 365
Cdd:PRK14025 286 HLGENEEADKVEKALEEVLALGLTTPDLGGNLSTMEMAEEVAKRV 330
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 4-365 1.96e-57

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 190.52  E-value: 1.96e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   4 KTKTITVLPGDHVGTEIVAEAIKSLKAIESNTPyqkiQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGP 83
Cdd:PRK03437   3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAGGP----GVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  84 kwgtgSVRP---EQG-LLKIRKELNLYANIRP--------CNFASDSLlelsplssevvkgTNLIIVRELVGGIYFGERE 151
Cdd:PRK03437  79 -----SVPSgvlERGlLLKLRFALDHYVNLRPsklypgvtSPLAGPGD-------------IDFVVVREGTEGPYTGNGG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 152 EQEESKDGKTAWDTEKYTVDEVTRITRMAaFMALQHNPPLPIWSLDKANVLA-SSRLWRRTVDKViSEEFPTLKVQHQLI 230
Cdd:PRK03437 141 ALRVGTPHEVATEVSVNTAFGVERVVRDA-FERAQKRPRKHLTLVHKTNVLTfAGDLWQRTVDEV-AAEYPDVTVDYQHV 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 231 DSAAMILIQNPTKLNgIIITSNMFGDIISDEASVIPGSLGLlpsASLASLPDTNTAFGLYEPCHGSAPDLP-KNKVNPIA 309
Cdd:PRK03437 219 DAATIFMVTDPSRFD-VIVTDNLFGDIITDLAAAVTGGIGL---AASGNINPTGTNPSMFEPVHGSAPDIAgQGIADPTA 294

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255731404 310 TILSAASMLRlSLDCVKEAEALEKAVQEVLdkgirTADLRGTSTTTEVGDAVAEAV 365
Cdd:PRK03437 295 AILSVALLLD-HLGEEDAAARIEAAVEADL-----AERGKMGRSTAEVGDRIAARL 344
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 5-363 3.92e-50

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 171.06  E-value: 3.92e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   5 TKTITVLPGDHVGTEIVAEAIKSLKAIESNtpyqkIQFEFKNhlIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGP- 83
Cdd:PRK08997   2 KQTITVIPGDGIGPSIIDATLKILDKLGCD-----FEYEFAD--AGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPv 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  84 KWGTGSVRpeqglLKIRKELNLYANIRPcnfasdsllelsplsSEVVKGT-------NLIIVRELVGGIYFGEreEQEES 156
Cdd:PRK08997  75 GEGFTSIN-----VTLRKKFDLYANVRP---------------VLSFPGTkarydniDIITVRENTEGMYSGE--GQTVS 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 157 KDGKTAWDTEKYTVDEVTRITRMAAFMALQHNPPlPIWSLDKANVLASSRLWRRTVDKVISEEFPTLKVQHQLIDSAAMI 236
Cdd:PRK08997 133 EDGETAEATSIITRKGAERIVRFAYELARKEGRK-KVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQ 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 237 LIQNPTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpDTntafGLYEPCHGSAPDLP-KNKVNPIATILSAA 315
Cdd:PRK08997 212 LVMNPEQFD-VIVTTNLFGDILSDLCAGLVGGLGMAPGANIGR--DA----AIFEAVHGSAPDIAgKNLANPTSVILAAI 284

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 255731404 316 SMLRlSLDCVKEAEALEKAVQEVLDKGIR-TADLRGTSTTTEVGDAVAE 363
Cdd:PRK08997 285 QMLE-YLGMPDKAERIRKAIVAVIEAGDRtTRDLGGTHGTTDFTQAVID 332
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 3-368 7.35e-49

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 168.36  E-value: 7.35e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   3 VKTKTITVLPGDHVGTEIVAEAIKSLKAIESntPYQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGG 82
Cdd:PRK08194   1 MKQFKIAVIPGDGVGKEVVPAAVRVLKAVAE--VHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  83 PK--------WGTgsvrpeqgLLKIRKELNLYANIRPCNFASDSLLELSPLssevvKGTNLIIVRE-------LVGG-IY 146
Cdd:PRK08194  79 PKlvpdhislWGL--------LIKIRREFEQVINIRPAKQLRGIKSPLANP-----KDFDLLVVREnsegeysEVGGrIH 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 147 FGEREeqeeskdgkTAWDTEKYTVDEVTRITRMAafMALQHNPPLPIWSLDKANVLASSRLWRRTVDKVISEEFPTLKVQ 226
Cdd:PRK08194 146 RGEDE---------IAIQNAVFTRKGTERAMRYA--FELAAKRRKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETD 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 227 HQLIDSAAMILIQNPTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLaslpDTNTAF-GLYEPCHGSAPDLP-KNK 304
Cdd:PRK08194 215 SQHIDALAAFFVTRPEEFD-VIVASNLFGDILTDIGAAIMGSIGIAPAANI----NVNGKYpSMFEPVHGSAPDIAgKGI 289

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255731404 305 VNPIATILSAASMlrlsLDCVKEAEA---LEKAVQEVLDKGIRTADLRGTSTTTEVGDAVAEAVARI 368
Cdd:PRK08194 290 ANPIGQIWTAKLM----LDHFGEEELgshLLDVIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKKL 352
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 1-363 5.22e-36

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 134.62  E-value: 5.22e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   1 MSVKTKTI--TVLPGDHVGTEIvAEAIKSLKAIesntpyQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLG 78
Cdd:PLN00118  35 FSSSSTPItaTLFPGDGIGPEI-AESVKQVFTA------AGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  79 AVGGPkWGTGsvrpEQGL-LKIRKELNLYANIRPCNfasdslleLSPLSSEVVKGTNLIIVRELVGGIYFGEREEqeesk 157
Cdd:PLN00118 108 PMATP-IGKG----HRSLnLTLRKELGLYANVRPCY--------SLPGYKTRYDDVDLVTIRENTEGEYSGLEHQ----- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 158 dgktawdTEKYTVDEVTRITRMA-------AFMALQHNPPLPIWSLDKANVLASSR-LWRRTVDKViSEEFPTLKVQHQL 229
Cdd:PLN00118 170 -------VVRGVVESLKIITRQAslrvaeyAFHYAKTHGRKRVSAIHKANIMKKTDgLFLKCCREV-AEKYPEIVYEEVI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 230 IDSAAMILIQNPTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLAslpdtNTAFGLYEPCHGSAPDLP-KNKVNPI 308
Cdd:PLN00118 242 IDNCCMMLVKNPALFD-VLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-----ENGLALAEAVHGSAPDIAgKNLANPT 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255731404 309 ATILSAASMLRlSLDCVKEAEALEKAVQEVLDKG-IRTADLRGTSTTTEVGDAVAE 363
Cdd:PLN00118 316 ALLLSAVMMLR-HLKLNEQAEQIHNAILNTIAEGkYRTADLGGSSTTTDFTKAICD 370
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-363 2.32e-29

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 118.07  E-value: 2.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   1 MSVKTKtITVLPGDHVGTEIVAEAIKSLKAIESNTPYQKIQFEFKNHLIGGAAidatGVPlpDEALECAKSSDAVLLGAV 80
Cdd:PRK09222   1 MAEKTP-ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEKVYKKGWTS----GIS--PSAWESIRRTKVLLKAPI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  81 GGPKwGTGsvrpEQGL-LKIRKELNLYANIRPCnfasdsllelsPLSSEVVK----GTNLIIVRE----LVGGIyfgERE 151
Cdd:PRK09222  74 TTPQ-GGG----YKSLnVTLRKTLGLYANVRPC-----------VSYHPFVEtkhpNLDVVIIREneedLYAGI---EHR 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 152 EQEE--------SKDGktawdTEKytvdevtrITRMAAFMALQHNPPlPIWSLDKANVLA-SSRLWRRTVDKvISEEFPT 222
Cdd:PRK09222 135 QTPDvyqclkliSRPG-----SEK--------IIRYAFEYARANGRK-KVTCLTKDNIMKlTDGLFHKVFDE-IAKEYPD 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 223 LKVQHQLIDSAAMILIQNPTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdtntAFGLYEPCHGSAPDLP- 301
Cdd:PRK09222 200 IEAEHYIVDIGAARLATNPENFD-VIVTPNLYGDILSDIAAEISGSVGLAGSANIGE------EYAMFEAVHGSAPDIAg 272

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255731404 302 KNKVNPIATILSAASMLRlSLDCVKEAEALEKAVQEVLDKGIRTADL--RGTST----TTEVGDAVAE 363
Cdd:PRK09222 273 KNIANPSGLLNAAVMMLV-HIGQFDIAELIENAWLKTLEDGIHTADIynEGVSKkkvgTKEFAEAVIE 339
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 13-363 2.24e-21

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 94.41  E-value: 2.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  13 GDHVGTEIVAEAIKSLK-AIEsnTPYQ-KIQFEFKNHLIGGAAIDATGVPLPDEALECAKSsdavLLGAVGGPkwgTGSv 90
Cdd:COG0538   26 GDGIGPEITRAIWKVIDaAVE--KAYGgKRDIEWKEVDAGEKARDETGDWLPDETAEAIKE----YGVGIKGP---LTT- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  91 rPEQGLLK-----IRKELNLYANIRPCnfasdsllelsplssEVVKG----------TNLIIVRELVGGIYFG---EREE 152
Cdd:COG0538   96 -PVGGGWRslnvtIRQILDLYVCRRPV---------------RYFKGvpspvkhpekVDIVIFRENTEDIYAGiewKAGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 153 QEESKDGKTAWDTEKYTVDEVT----------------RITRMAAFMALQHNPPlPIWSLDKANVLASS----RLWRRTV 212
Cdd:COG0538  160 PEALKLIFFLEDEMGVTVIRFPedsgigikpvsdegteRLVRAAIQYALDNKRK-SVTLVHKGNIMKFTegafKDWGYEV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 213 ------DKVISEEFPT----------LKVQHQLIDSAAMILIQNPTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSAS 276
Cdd:COG0538  239 aeeefgDKFITEGPWEkykgpkpagkIVYKDRIADDMLQQILLRPGEYD-VIATKNLNGDYISDALAAQVGGLGIAPGAN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 277 LAslPDTNtafGLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLsLDCVKEAEALEKAVQEVLDKGIRTADL-RGTS-- 352
Cdd:COG0538  318 IG--DDGG---AEFEATHGTAPKYAgKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLaRLMEga 391

                        410
                 ....*....|....
gi 255731404 353 ---TTTEVGDAVAE 363
Cdd:COG0538  392 telSTSEFGDAIIE 405
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
8-363 4.33e-20

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 91.05  E-value: 4.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   8 ITVLPGDHVGTEIVAEAIKSLKAIESNTPYQKIQFEFKNHLIGGAAIDATGVPLPDEALECAKSSDAVLLGAVGGP---K 84
Cdd:PRK06451  26 ILYVEGDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  85 WGTGSVRpeqgllkIRKELNLYANIRPCNFASDSLLELSPLSSevvkgTNLIIVRELVGGIYFG---EREEQEESKDGKT 161
Cdd:PRK06451 106 WKSINVA-------IRLMLDLYANIRPVKYIPGIESPLKNPEK-----IDLIIFRENTDDLYRGieyPYDSEEAKKIRDF 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 162 AWDTEKYTVDEVT-------------RITRMAAFMALQHNPPlPIWSLDKANVL----ASSRLWRRTV------DKVISE 218
Cdd:PRK06451 174 LRKELGVEVEDDTgigikliskfktqRIARMAIKYAIDHKRK-KVTIMHKGNVMkyteGAFREWAYEValkefrDYVVTE 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 219 E---------FPTLKV--QHQLIDSAAMILIQNPTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLAslpDTNtaf 287
Cdd:PRK06451 253 EevtknyngvPPSGKViiNDRIADNMFQQIIIRPDEYD-IILAPNVNGDYISDAAGALVGNIGMLGGANIG---DTG--- 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 288 GLYEPCHGSAPDLP-KNKVNPIATILSAASMLRLsLDCVKEAEALEKAVQEVLDKGIRTADLR---GTS--TTTEVGDAV 361
Cdd:PRK06451 326 GMFEAIHGTAPKYAgKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLArfmGVRalSTTEYTDEL 404


                 ..
gi 255731404 362 AE 363
Cdd:PRK06451 405 IS 406
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 6-361 2.05e-17

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 82.60  E-value: 2.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   6 KTITVLPGDHVGTEIVAEAIKSLKAIESntpyqKIQFEfKNHLIGGAAidatgvPLPDEALECAKSSDAVLLGAVGGP-K 84
Cdd:PLN00123  31 RAVTLIPGDGIGPLVTGAVEQVMEAMHA-----PVYFE-RYEVHGDMK------KVPEEVLESIRRNKVCLKGGLATPvG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  85 WGTGSVRpeqglLKIRKELNLYANIRPC-NFASDSLLElsplssevvKGTNLIIVRELVGGIYFG-EREEQE---ESKDG 159
Cdd:PLN00123  99 GGVSSLN-----VQLRKELDLFASLVNCfNLPGLPTRH---------ENVDIVVIRENTEGEYSGlEHEVVPgvvESLKV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 160 KTAWDTEkytvdevtRITRMAAFMALQHNPPlPIWSLDKANVLA-SSRLWRRTVDKViSEEFPTLKVQHQLIDSAAMILI 238
Cdd:PLN00123 165 ITKFCSE--------RIAKYAFEYAYLNNRK-KVTAVHKANIMKlADGLFLESCREV-AKKYPGIKYNEIIVDNCCMQLV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 239 QNPTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLAslpDTNTAF--GLYEPCHGSAPDLPKNKVNPIATILSAAS 316
Cdd:PLN00123 235 SKPEQFD-VMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG---ADHAVFeqGASAGNVGNEKLVEQKKANPVALLLSSAM 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 255731404 317 MLRlSLDCVKEAEALEKAVQEVLDKG-IRTADLRGTSTTTEVGDAV 361
Cdd:PLN00123 311 MLR-HLQFPSFADRLETAVKRVIAEGkYRTKDLGGSSTTQEVVDAV 355
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 8-319 7.11e-09

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 56.99  E-value: 7.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404   8 ITVLPGDHVGTEIVAEAIKSLKAIESNTPYQKIQFEFKNHLIGGAAIDATG--VPLPDEALECAK----SSDAVLLGAVG 81
Cdd:PRK07006  22 IPFIEGDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATKVYGedVWLPEETLDLIReyrvAIKGPLTTPVG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404  82 GpkwGTGSVRpeqglLKIRKELNLYANIRPCNFASDSLLElsplssevVK---GTNLIIVRELVGGIYFGeREEQEESKD 158
Cdd:PRK07006 102 G---GIRSLN-----VALRQELDLYVCLRPVRYFKGVPSP--------VKrpeDTDMVIFRENSEDIYAG-IEWKAGSAE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 159 GKTAWD--TEKYTVDEV------------------TRITRMAAFMALQHNPPlPIWSLDKANVL----ASSRLW------ 208
Cdd:PRK07006 165 AKKVIKflQEEMGVKKIrfpetsgigikpvseegtERLVRAAIEYAIDNDRK-SVTLVHKGNIMkfteGAFKDWgyqlae 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 209 RRTVDKVIS----EEFPTLKVQHQLI--DSAAMILIQN----PTKLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLa 278
Cdd:PRK07006 244 EEFGDELIDggpwDKIKNPETGKEIIvkDSIADAFLQQillrPAEYD-VIATMNLNGDYISDALAAQVGGIGIAPGANI- 321

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 255731404 279 slpdtNTAFGLYEPCHGSAPDLP-KNKVNPIATILSAASMLR 319
Cdd:PRK07006 322 -----NDGHAIFEATHGTAPKYAgLDKVNPGSVILSAEMMLR 358
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
247-318 4.25e-06

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 48.56  E-value: 4.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255731404 247 IIITSNMFGDIISDEASVIPGSLGLLPSASLAslpDTNTAFglyEPCHGSAPDLPK-NKVNPIATILSAASML 318
Cdd:PRK07362 355 ILATLNLNGDYISDAAAAIVGGLGMAPGANIG---DNAAIF---EATHGTAPKHAGlDRINPGSVILSGVMML 421
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
227-369 2.25e-03

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 39.84  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 227 HQLIDSA-AMILiqnptKLNGIII--TSNMFGDIISDEASVIPGSLGLLPSAsLASlPDTNTAfgLYEPCHGSAP----D 299
Cdd:PRK08299 246 HRLIDDMvASAL-----KWEGGYVwaCKNYDGDVQSDTVAQGFGSLGLMTSV-LMT-PDGKTV--EAEAAHGTVTrhyrQ 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255731404 300 LPKNK---VNPIATIL--SAASMLRLSLDCVKE----AEALEKAVQEVLDKGIRTADL-------RGTSTTTEVGDAVAE 363
Cdd:PRK08299 317 HQKGEetsTNPIASIFawTRGLAHRGKLDGNPElvkfADTLEKVCIETVESGFMTKDLallvgpdQKWLTTEEFLDAIDE 396


                 ....*.
gi 255731404 364 AVARIL 369
Cdd:PRK08299 397 NLEKAL 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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