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Conserved domains on  [gi|2241009269|ref|XP_002511732|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 [Ricinus communis]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 11477399)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 1-1780 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3683.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269    1 MASSEADSRLNQVVAPALEKIIKNASWRKHSKLAHECKSVLEKLTSPQKQ------HSPDSDPDASIPGPLHDGGPIEYS 74
Cdd:PLN03076     1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNppstssAAADSASASSLPGPLHDGGSIEYS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   75 LAESESVLSPLINACGTGFLKIVDPAVDCIQKLIAHGYLRGEADPTGGsPEAQLLSKLIESVCKCYDIGDDAIELSVLKT 154
Cdd:PLN03076    81 LAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGG-PEALLLAKLIESVCKCHDLGDEGIELLVLKT 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  155 LLSAVTSISLRIHSDCLLQIVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPVEKSD 234
Cdd:PLN03076   160 LLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKSD 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  235 ADGSMTMFVQGFITKIMQDIDVVLSTGGTPSKVSVGAHDGAFETTATVETTNPADLLDSTDKDMLDAKYWEISMYKTALE 314
Cdd:PLN03076   240 SDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGSGAHDGAFETTATVETTNPADLLDSTDKDMLDAKYWEISMYKSALE 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  315 GRKGELADGEVERDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEASADPQLMRGKIVALELLKILLENAGAVFRTSD 394
Cdd:PLN03076   320 GRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRTSD 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  395 RFLGAIKQYLCLSLLKNSASSLMIVFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLEK 474
Cdd:PLN03076   400 RFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLDK 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  475 LCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGTTTTLLPPQEATMKLEAMKCLVAILKSMGDWMNKQLRI 554
Cdd:PLN03076   480 LCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRL 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  555 PDVHSTKKLDVADNIPEPGCLAMANGNGDEPVEGSDSHSEASTEASDVSTIEQRRAYKLELQEGISLFNRKPKKGIEFLI 634
Cdd:PLN03076   560 PDPASLKKLDAVENNLEPGSLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLI 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  635 NANKVGNSPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRVFLQGFRLPGEAQKIDRIM 714
Cdd:PLN03076   640 NANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIM 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  715 EKFAERYCKCNPKVFTSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEYLRSLFERISRNEIK 794
Cdd:PLN03076   720 EKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIK 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  795 MKEDDLALQQKQSMNSNKILGLDGILNIVIRKRGEDR-METSEDLIKHMQEQFKEKARKSESVYYAATDVVILRFMIEVC 873
Cdd:PLN03076   800 MKEDDLVPQQKQSANSNRILGLDSILNIVIRKRGEDSyMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVC 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  874 WAPMLAAFSVPLDQSDDEVVLALCLEGFRCAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVTIADE 953
Cdd:PLN03076   880 WAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADE 959

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  954 DGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAFPQNESDKSKQSKSTILPVLKKKGPGRMQYAAAAVMRGSYDSA 1033
Cdd:PLN03076   960 DGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAAAAVRRGSYDSA 1039

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1034 GIGGGASGAVTSEQMNNLVSNLNMLEQVGSSEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSASDPRVFSLTKIVEI 1113
Cdd:PLN03076  1040 GVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEI 1119

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1114 AHYNMNRIRLVWSSIWHVLSDFFVNIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSSAVEI 1193
Cdd:PLN03076  1120 AHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEI 1199

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1194 RELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIMEKIIRDYFPYITETETTTFTDCVNCLIAFTN 1273
Cdd:PLN03076  1200 RELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTN 1279

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1274 SRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAtgkiPPSSPQAGKEGKHDNGEIGDKEDHLYFWFPLLAGLSEL 1353
Cdd:PLN03076  1280 SRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEA----PPSSPQSGKDGKQESGEFTDKDDHLYFWFPLLAGLSEL 1355

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1354 SFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPTGGDSP-GQGIDSdDAGELDQDAWLYE 1432
Cdd:PLN03076  1356 SFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPeGQGVDG-DQGELDQDAWLYE 1434

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1433 TCTLALQLVVDLFVKFYSTVNPLLRKVLMLLVSFIRRPHQSLAGIGIAAFVRLMSNAGDLFSEEKWLEVVLSLKEAANAT 1512
Cdd:PLN03076  1435 TCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANAT 1514

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1513 LPDFSYIATGVSTvgSHKAIIGQNNGESTGSGTPDDDPERLMTRRLYISLSDAKCRAAVQLLLIQAVMEIYNMYRPHLSA 1592
Cdd:PLN03076  1515 LPDFSYVVSGEYM--PAENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSA 1592

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1593 KNTLVLFDALHDVASHAHKINTDTTLRARLQEFGSMTQMQDPPLLRLENESYQICLTFLQNLTLDRPPGFDEVEVESYLV 1672
Cdd:PLN03076  1593 KNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLV 1672

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1673 NLCGEVLEFYIETSRSGQISQLSSSAQSQWLIPVGSGKRRELAARAPLIVATLQAICSLGDASFEKNLSHFFPLLSGLIS 1752
Cdd:PLN03076  1673 ELCEEVLQFYIETSTAGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLIS 1752

                         1770      1780
                   ....*....|....*....|....*...
gi 2241009269 1753 CEHGSNEVQVALSDMLSSTVGPVLLRSC 1780
Cdd:PLN03076  1753 CEHGSNEVQVALSDMLSSWVGPVLLQSC 1780
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 1-1780 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3683.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269    1 MASSEADSRLNQVVAPALEKIIKNASWRKHSKLAHECKSVLEKLTSPQKQ------HSPDSDPDASIPGPLHDGGPIEYS 74
Cdd:PLN03076     1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNppstssAAADSASASSLPGPLHDGGSIEYS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   75 LAESESVLSPLINACGTGFLKIVDPAVDCIQKLIAHGYLRGEADPTGGsPEAQLLSKLIESVCKCYDIGDDAIELSVLKT 154
Cdd:PLN03076    81 LAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGG-PEALLLAKLIESVCKCHDLGDEGIELLVLKT 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  155 LLSAVTSISLRIHSDCLLQIVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPVEKSD 234
Cdd:PLN03076   160 LLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKSD 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  235 ADGSMTMFVQGFITKIMQDIDVVLSTGGTPSKVSVGAHDGAFETTATVETTNPADLLDSTDKDMLDAKYWEISMYKTALE 314
Cdd:PLN03076   240 SDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGSGAHDGAFETTATVETTNPADLLDSTDKDMLDAKYWEISMYKSALE 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  315 GRKGELADGEVERDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEASADPQLMRGKIVALELLKILLENAGAVFRTSD 394
Cdd:PLN03076   320 GRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRTSD 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  395 RFLGAIKQYLCLSLLKNSASSLMIVFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLEK 474
Cdd:PLN03076   400 RFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLDK 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  475 LCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGTTTTLLPPQEATMKLEAMKCLVAILKSMGDWMNKQLRI 554
Cdd:PLN03076   480 LCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRL 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  555 PDVHSTKKLDVADNIPEPGCLAMANGNGDEPVEGSDSHSEASTEASDVSTIEQRRAYKLELQEGISLFNRKPKKGIEFLI 634
Cdd:PLN03076   560 PDPASLKKLDAVENNLEPGSLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLI 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  635 NANKVGNSPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRVFLQGFRLPGEAQKIDRIM 714
Cdd:PLN03076   640 NANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIM 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  715 EKFAERYCKCNPKVFTSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEYLRSLFERISRNEIK 794
Cdd:PLN03076   720 EKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIK 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  795 MKEDDLALQQKQSMNSNKILGLDGILNIVIRKRGEDR-METSEDLIKHMQEQFKEKARKSESVYYAATDVVILRFMIEVC 873
Cdd:PLN03076   800 MKEDDLVPQQKQSANSNRILGLDSILNIVIRKRGEDSyMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVC 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  874 WAPMLAAFSVPLDQSDDEVVLALCLEGFRCAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVTIADE 953
Cdd:PLN03076   880 WAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADE 959

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  954 DGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAFPQNESDKSKQSKSTILPVLKKKGPGRMQYAAAAVMRGSYDSA 1033
Cdd:PLN03076   960 DGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAAAAVRRGSYDSA 1039

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1034 GIGGGASGAVTSEQMNNLVSNLNMLEQVGSSEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSASDPRVFSLTKIVEI 1113
Cdd:PLN03076  1040 GVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEI 1119

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1114 AHYNMNRIRLVWSSIWHVLSDFFVNIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSSAVEI 1193
Cdd:PLN03076  1120 AHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEI 1199

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1194 RELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIMEKIIRDYFPYITETETTTFTDCVNCLIAFTN 1273
Cdd:PLN03076  1200 RELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTN 1279

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1274 SRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAtgkiPPSSPQAGKEGKHDNGEIGDKEDHLYFWFPLLAGLSEL 1353
Cdd:PLN03076  1280 SRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEA----PPSSPQSGKDGKQESGEFTDKDDHLYFWFPLLAGLSEL 1355

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1354 SFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPTGGDSP-GQGIDSdDAGELDQDAWLYE 1432
Cdd:PLN03076  1356 SFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPeGQGVDG-DQGELDQDAWLYE 1434

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1433 TCTLALQLVVDLFVKFYSTVNPLLRKVLMLLVSFIRRPHQSLAGIGIAAFVRLMSNAGDLFSEEKWLEVVLSLKEAANAT 1512
Cdd:PLN03076  1435 TCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANAT 1514

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1513 LPDFSYIATGVSTvgSHKAIIGQNNGESTGSGTPDDDPERLMTRRLYISLSDAKCRAAVQLLLIQAVMEIYNMYRPHLSA 1592
Cdd:PLN03076  1515 LPDFSYVVSGEYM--PAENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSA 1592

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1593 KNTLVLFDALHDVASHAHKINTDTTLRARLQEFGSMTQMQDPPLLRLENESYQICLTFLQNLTLDRPPGFDEVEVESYLV 1672
Cdd:PLN03076  1593 KNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLV 1672

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1673 NLCGEVLEFYIETSRSGQISQLSSSAQSQWLIPVGSGKRRELAARAPLIVATLQAICSLGDASFEKNLSHFFPLLSGLIS 1752
Cdd:PLN03076  1673 ELCEEVLQFYIETSTAGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLIS 1752

                         1770      1780
                   ....*....|....*....|....*...
gi 2241009269 1753 CEHGSNEVQVALSDMLSSTVGPVLLRSC 1780
Cdd:PLN03076  1753 CEHGSNEVQVALSDMLSSWVGPVLLQSC 1780
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 612-793 1.41e-103

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 328.65  E-value: 1.41e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  612 KLELQEGISLFNRKPKKGIEFLINANKVGNSPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFD 691
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  692 EAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFTSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGID 771
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 2241009269  772 DGKDLPEEYLRSLFERISRNEI 793
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 611-793 9.52e-89

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 286.43  E-value: 9.52e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  611 YKLELQEGISLFNRKPKKGIEFLINANKV-GNSPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGME 689
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  690 FDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFT-SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNR 768
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                          170       180
                   ....*....|....*....|....*
gi 2241009269  769 GIDDGKDLPEEYLRSLFERISRNEI 793
Cdd:cd00171    161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 611-793 3.89e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 262.23  E-value: 3.89e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   611 YKLELQEGISLFNRKPKKGIEFLINANKVGN-SPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGME 689
Cdd:smart00222    4 RKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSAKD 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   690 FDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFT--SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNN 767
Cdd:smart00222   84 LDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIKNV 163

                           170       180
                    ....*....|....*....|....*.
gi 2241009269   768 RGIDDGKDLPEEYLRSLFERISRNEI 793
Cdd:smart00222  164 RGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 1-1780 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3683.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269    1 MASSEADSRLNQVVAPALEKIIKNASWRKHSKLAHECKSVLEKLTSPQKQ------HSPDSDPDASIPGPLHDGGPIEYS 74
Cdd:PLN03076     1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNppstssAAADSASASSLPGPLHDGGSIEYS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   75 LAESESVLSPLINACGTGFLKIVDPAVDCIQKLIAHGYLRGEADPTGGsPEAQLLSKLIESVCKCYDIGDDAIELSVLKT 154
Cdd:PLN03076    81 LAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGG-PEALLLAKLIESVCKCHDLGDEGIELLVLKT 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  155 LLSAVTSISLRIHSDCLLQIVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPVEKSD 234
Cdd:PLN03076   160 LLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKSD 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  235 ADGSMTMFVQGFITKIMQDIDVVLSTGGTPSKVSVGAHDGAFETTATVETTNPADLLDSTDKDMLDAKYWEISMYKTALE 314
Cdd:PLN03076   240 SDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGSGAHDGAFETTATVETTNPADLLDSTDKDMLDAKYWEISMYKSALE 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  315 GRKGELADGEVERDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEASADPQLMRGKIVALELLKILLENAGAVFRTSD 394
Cdd:PLN03076   320 GRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRTSD 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  395 RFLGAIKQYLCLSLLKNSASSLMIVFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLEK 474
Cdd:PLN03076   400 RFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLDK 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  475 LCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGTTTTLLPPQEATMKLEAMKCLVAILKSMGDWMNKQLRI 554
Cdd:PLN03076   480 LCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRL 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  555 PDVHSTKKLDVADNIPEPGCLAMANGNGDEPVEGSDSHSEASTEASDVSTIEQRRAYKLELQEGISLFNRKPKKGIEFLI 634
Cdd:PLN03076   560 PDPASLKKLDAVENNLEPGSLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLI 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  635 NANKVGNSPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRVFLQGFRLPGEAQKIDRIM 714
Cdd:PLN03076   640 NANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIM 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  715 EKFAERYCKCNPKVFTSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEYLRSLFERISRNEIK 794
Cdd:PLN03076   720 EKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIK 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  795 MKEDDLALQQKQSMNSNKILGLDGILNIVIRKRGEDR-METSEDLIKHMQEQFKEKARKSESVYYAATDVVILRFMIEVC 873
Cdd:PLN03076   800 MKEDDLVPQQKQSANSNRILGLDSILNIVIRKRGEDSyMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVC 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  874 WAPMLAAFSVPLDQSDDEVVLALCLEGFRCAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVTIADE 953
Cdd:PLN03076   880 WAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADE 959

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  954 DGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAFPQNESDKSKQSKSTILPVLKKKGPGRMQYAAAAVMRGSYDSA 1033
Cdd:PLN03076   960 DGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAAAAVRRGSYDSA 1039

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1034 GIGGGASGAVTSEQMNNLVSNLNMLEQVGSSEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSASDPRVFSLTKIVEI 1113
Cdd:PLN03076  1040 GVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEI 1119

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1114 AHYNMNRIRLVWSSIWHVLSDFFVNIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSSAVEI 1193
Cdd:PLN03076  1120 AHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEI 1199

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1194 RELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIMEKIIRDYFPYITETETTTFTDCVNCLIAFTN 1273
Cdd:PLN03076  1200 RELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTN 1279

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1274 SRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAtgkiPPSSPQAGKEGKHDNGEIGDKEDHLYFWFPLLAGLSEL 1353
Cdd:PLN03076  1280 SRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEA----PPSSPQSGKDGKQESGEFTDKDDHLYFWFPLLAGLSEL 1355

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1354 SFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPTGGDSP-GQGIDSdDAGELDQDAWLYE 1432
Cdd:PLN03076  1356 SFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPeGQGVDG-DQGELDQDAWLYE 1434

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1433 TCTLALQLVVDLFVKFYSTVNPLLRKVLMLLVSFIRRPHQSLAGIGIAAFVRLMSNAGDLFSEEKWLEVVLSLKEAANAT 1512
Cdd:PLN03076  1435 TCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANAT 1514

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1513 LPDFSYIATGVSTvgSHKAIIGQNNGESTGSGTPDDDPERLMTRRLYISLSDAKCRAAVQLLLIQAVMEIYNMYRPHLSA 1592
Cdd:PLN03076  1515 LPDFSYVVSGEYM--PAENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSA 1592

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1593 KNTLVLFDALHDVASHAHKINTDTTLRARLQEFGSMTQMQDPPLLRLENESYQICLTFLQNLTLDRPPGFDEVEVESYLV 1672
Cdd:PLN03076  1593 KNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLV 1672

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1673 NLCGEVLEFYIETSRSGQISQLSSSAQSQWLIPVGSGKRRELAARAPLIVATLQAICSLGDASFEKNLSHFFPLLSGLIS 1752
Cdd:PLN03076  1673 ELCEEVLQFYIETSTAGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLIS 1752

                         1770      1780
                   ....*....|....*....|....*...
gi 2241009269 1753 CEHGSNEVQVALSDMLSSTVGPVLLRSC 1780
Cdd:PLN03076  1753 CEHGSNEVQVALSDMLSSWVGPVLLQSC 1780
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 612-793 1.41e-103

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 328.65  E-value: 1.41e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  612 KLELQEGISLFNRKPKKGIEFLINANKVGNSPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFD 691
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  692 EAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFTSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGID 771
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 2241009269  772 DGKDLPEEYLRSLFERISRNEI 793
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 611-793 9.52e-89

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 286.43  E-value: 9.52e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  611 YKLELQEGISLFNRKPKKGIEFLINANKV-GNSPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGME 689
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  690 FDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFT-SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNR 768
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                          170       180
                   ....*....|....*....|....*
gi 2241009269  769 GIDDGKDLPEEYLRSLFERISRNEI 793
Cdd:cd00171    161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 611-793 3.89e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 262.23  E-value: 3.89e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   611 YKLELQEGISLFNRKPKKGIEFLINANKVGN-SPEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGME 689
Cdd:smart00222    4 RKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSAKD 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   690 FDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFT--SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNN 767
Cdd:smart00222   84 LDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIKNV 163

                           170       180
                    ....*....|....*....|....*.
gi 2241009269   768 RGIDDGKDLPEEYLRSLFERISRNEI 793
Cdd:smart00222  164 RGSNDGEDLPREFLEELYDSIKNNEI 189
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 339-494 1.15e-52

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 181.92  E-value: 1.15e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269  339 LRRDAFLVFRALCKLSMKTPPKEASADPQLMRGKIVALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMI 418
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSNGKPLSKSDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSSFP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2241009269  419 VFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAqpNFQQKMIVLRFLEKLCVDSQILVDIFINYDCDVN 494
Cdd:pfam12783   81 VFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLESDS--SLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1570-1769 1.30e-43

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 157.02  E-value: 1.30e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1570 AVQLLLIQAVMEIYNMYRPHLSAKNTLVLFDALHDVASHAHKINTDTTLRARLQEFGSMTQMqdPPLLRLENESYQICLT 1649
Cdd:pfam20252    1 VVQLLLIQTVNEILDEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLELRTALWRAGFMKQL--PNLLKQETSSLSTYLR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1650 FLQNLTLDRPPGFDEVE-VESYLVNLCGEVLEFYIETsrsgqisqlsssaqsqwlipVGSGKRRELAARAPLIVATLQAI 1728
Cdd:pfam20252   79 ILFRLYADDEPRTSQREeVEERLIPLCEDILEYYLSL--------------------DEEEKQRELAAWTPVVVLILQGL 138

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2241009269 1729 CSLGDASFEKNLSHFFPLLSGLISCEhGSNEVQVALSDMLS 1769
Cdd:pfam20252  139 LALPDDDFRRHLPEFYPLLCDLILCE-LSPEVRLALREFFS 178
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 6-209 6.89e-42

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 151.64  E-value: 6.89e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269    6 ADSRLNQVVAPALeKIIKNASWRKHSKLAHECKSVLEKLTSPQKQHspdsdpdasipgplhdggPIEYSLA-ESESVLSP 84
Cdd:pfam16213    1 QGSKLLEALQSDL-RTLSSEAKRKYPPVKEASEKGILRLRTVHSSS------------------PLMQNLLsASEDILKP 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269   85 LINACGTGFLKIVDPAVDCIQKLIAHGYLRGEAdptggspeaqlLSKLIESVCKCYDIGDDaIELSVLKTLLSAVTSISl 164
Cdd:pfam16213   62 FVLACETKNPKLVQIALGCLQKLISHDAISQSA-----------APYILDTLWMLMELGSE-IELKVLQTVLLLITTNS- 128

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2241009269  165 RIHSDCLLQIVRTCYDIYLgSKNVVNQTTAKASLIQMLVIVFRRM 209
Cdd:pfam16213  129 VIHGDTLAKALVLCFRLHF-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1161-1244 1.59e-35

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 130.30  E-value: 1.59e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1161 KFLEREELANYNFQNEFMKPFVIVMRKSSAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFE 1240
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ....
gi 2241009269 1241 IMEK 1244
Cdd:pfam09324   81 ILEL 84
Mon2_C pfam16206
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
 1342-1445 1.29e-11

C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.


Pssm-ID: 465066  Cd Length: 827  Bit Score: 69.76  E-value: 1.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2241009269 1342 FWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRH---AIDPTGGDSPGQGIDS 1418
Cdd:pfam16206   92 LWLCLYAKLGELCVDLRPAVRKSAGQTLFSTIGAHGSLLNHPTWHALIWKVLFNLLDNVRAlssSADKEKIDAGGGNILI 171

                           90       100
                   ....*....|....*....|....*..
gi 2241009269 1419 DDAGELDQDAWLyETCTLALQLVVDLF 1445
Cdd:pfam16206  172 HHSRDTAEKQWA-ETQVLTLAGVARIF 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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