|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
158-627 |
9.62e-134 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 403.37 E-value: 9.62e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 158 NELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAeplaenseeky 237
Cdd:COG0513 5 ADLGLSPPLLKALAELGYTTPTPIQAQAIPLIL-AGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAP----------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 238 aeggilRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVEL 317
Cdd:COG0513 73 ------QALILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGA---LDL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 318 HSLSFFVLDEADRMVENGHFHELQSIIDILPKtsgsmeslsqntencftvsniqrkKRQTFVFSATIAlsadfrkklkrg 397
Cdd:COG0513 144 SGVETLVLDEADRMLDMGFIEDIERILKLLPK------------------------ERQTLLFSATMP------------ 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 398 alrskqlmndglNSIETLSERAgMRpNAAIVDLTNASIMANKLEESFIECREEDKDAYLYYILSVHGQGRTIVFCTSIAA 477
Cdd:COG0513 188 ------------PEIRKLAKRY-LK-NPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEDPERAIVFCNTKRG 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 478 LRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTA 557
Cdd:COG0513 254 ADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTG 333
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225433316 558 RASADGCSIALISPNDRSKFANLcksfskESFQRFPIESSYMP--EVVKRLSLARQIDKISRKDSQEKAKKS 627
Cdd:COG0513 334 RAGAEGTAISLVTPDERRLLRAI------EKLIGQKIEEEELPgfEPVEEKRLERLKPKIKEKLKGKKAGRG 399
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
166-429 |
4.39e-110 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 334.98 E-value: 4.39e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAHQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAEplaeNSEEKYaeggiLRA 245
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGV----GGKQKP-----LRA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEDHLVELHSLSFFVL 325
Cdd:cd17946 72 LILTPTRELAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANLKSLRFLVL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 326 DEADRMVENGHFHELQSIIDILPKTsgsmeslsqntencftvSNIQRKKRQTFVFSATIALSADFRKKLKRgalRSKQLM 405
Cdd:cd17946 152 DEADRMLEKGHFAELEKILELLNKD-----------------RAGKKRKRQTFVFSATLTLDHQLPLKLNS---KKKKKK 211
|
250 260
....*....|....*....|....
gi 225433316 406 NDGLNSIETLSERAGMRPNAAIVD 429
Cdd:cd17946 212 KEKKQKLELLIEKVGFRKKPKVID 235
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
158-601 |
7.70e-73 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 245.10 E-value: 7.70e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 158 NELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseeky 237
Cdd:PRK11776 7 STLPLPPALLANLNELGYTEMTPIQAQSLPAIL-AGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFR------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 238 aeggiLRALIITPTRELALQVTDHLKEVAKGT-NVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEDHLVE 316
Cdd:PRK11776 73 -----VQALVLCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 317 LHSLsffVLDEADRMVENGHFHELQSIIDILPKtsgsmeslsqntencftvsniqrkKRQTFVFSATIAlsadfrkklkr 396
Cdd:PRK11776 148 LNTL---VLDEADRMLDMGFQDAIDAIIRQAPA------------------------RRQTLLFSATYP----------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 397 galrskqlmndglNSIETLSERAgMR-PNAAIVDLTNAsimANKLEESFIECREEDKDAYLYYILSVHGQGRTIVFCTSI 475
Cdd:PRK11776 190 -------------EGIAAISQRF-QRdPVEVKVESTHD---LPAIEQRFYEVSPDERLPALQRLLLHHQPESCVVFCNTK 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 476 AALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGR 555
Cdd:PRK11776 253 KECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGR 332
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 225433316 556 TARASADGCSIALISPNDRSKFANLcksfskESFQRFPIESSYMPE 601
Cdd:PRK11776 333 TGRAGSKGLALSLVAPEEMQRANAI------EDYLGRKLNWEPLPS 372
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
166-384 |
2.11e-72 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 234.64 E-value: 2.11e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseekyaEGGILRA 245
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLIL-SGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKK--------------KGRGPQA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVELHSLSFFVL 325
Cdd:cd00268 66 LVLAPTRELAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGK---LDLSNVKYLVL 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 225433316 326 DEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATI 384
Cdd:cd00268 143 DEADRMLDMGFEEDVEKILSALP------------------------KDRQTLLFSATL 177
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
157-660 |
9.84e-69 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 233.30 E-value: 9.84e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLE-EREKAAEPlaensee 235
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPAL-DGRDVLGSAPTGTGKTAAFLLPALQHLLDfPRRKSGPP------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 236 kyaeggilRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEDHLV 315
Cdd:PRK11192 75 --------RILILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 316 ELHSLsffVLDEADRMVENGhfhelqsiidilpktsgsmesLSQNTEncfTVSNIQRKKRQTFVFSATIALSA--DFrkk 393
Cdd:PRK11192 147 AVETL---ILDEADRMLDMG---------------------FAQDIE---TIAAETRWRKQTLLFSATLEGDAvqDF--- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 394 lkrgalrSKQLMND--GLNSIETLSERAGMRPNAAIVDltnasimaNKleesfiecreEDKDAYLYYILSVHGQGRTIVF 471
Cdd:PRK11192 197 -------AERLLNDpvEVEAEPSRRERKKIHQWYYRAD--------DL----------EHKTALLCHLLKQPEVTRSIVF 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 472 CTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVH 551
Cdd:PRK11192 252 VRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLH 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 552 RSGRTARASADGCSIALISPNDrskFANLCKsfskesfqrfpIEsSYMPEVVKRlslaRQIDKISRKDSQEKAKKSwFEQ 631
Cdd:PRK11192 332 RIGRTGRAGRKGTAISLVEAHD---HLLLGK-----------IE-RYIEEPLKA----RVIDELRPKTKAPSEKKT-GKP 391
|
490 500
....*....|....*....|....*....
gi 225433316 632 NAEALELIVDESDSEEEKVKIHKQKKASS 660
Cdd:PRK11192 392 SKKVLAKRAEKKEKEKEKPKVKKRHRDTK 420
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
157-573 |
3.86e-63 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 219.40 E-value: 3.86e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQkACIPAAAHQGKDVVGASETGSGKTLALGLPILQRLLEerekaaeplAENSEEK 236
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQ-AQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQ---------TPPPKER 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 237 YAegGILRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKAR-PEIVVGTPGRLWELMSRGEDHlv 315
Cdd:PRK01297 159 YM--GEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVH-- 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 316 eLHSLSFFVLDEADRMVENGHFHELQSIIDILPKTSgsmeslsqntencftvsniqrkKRQTFVFSATIalsadfrkklk 395
Cdd:PRK01297 235 -LDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKE----------------------ERQTLLFSATF----------- 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 396 rgalrSKQLMNdglnsietLSERAGMRPnaAIVDLTNASIMANKLEESFIECREEDKDAYLYYILSVHGQGRTIVFCTSI 475
Cdd:PRK01297 281 -----TDDVMN--------LAKQWTTDP--AIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVTQNPWERVMVFANRK 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 476 AALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGR 555
Cdd:PRK01297 346 DEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGR 425
|
410
....*....|....*...
gi 225433316 556 TARASADGCSIALISPND 573
Cdd:PRK01297 426 TGRAGASGVSISFAGEDD 443
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
159-384 |
1.53e-56 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 192.44 E-value: 1.53e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 159 ELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLleerekaaeplaenSEEKYa 238
Cdd:cd17955 3 DLGLSSWLVKQCASLGIKEPTPIQKLCIPEIL-AGRDVIGGAKTGSGKTAAFALPILQRL--------------SEDPY- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 239 egGILrALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEDHLVELH 318
Cdd:cd17955 67 --GIF-ALVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDTTKVLS 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225433316 319 SLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATI 384
Cdd:cd17955 144 RVKFLVLDEADRLLTGSFEDDLATILSALP------------------------PKRQTLLFSATL 185
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
157-400 |
2.77e-54 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 185.98 E-value: 2.77e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseek 236
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVAL-QGRDIIGLAETGSGKTAAFALPILQALLENPQR------------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 237 yaeggiLRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWelmsrgeDHL-- 314
Cdd:cd17954 69 ------FFALVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLV-------DHLen 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 315 ---VELHSLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATIALSADfr 391
Cdd:cd17954 136 tkgFSLKSLKFLVMDEADRLLNMDFEPEIDKILKVIP------------------------RERTTYLFSATMTTKVA-- 189
|
....*....
gi 225433316 392 kKLKRGALR 400
Cdd:cd17954 190 -KLQRASLK 197
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
157-568 |
2.00e-53 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 194.78 E-value: 2.00e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEeREKAAEPLAENSeek 236
Cdd:PRK04537 11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVAL-PGGDVAGQAQTGTGKTLAFLVAVMNRLLS-RPALADRKPEDP--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 237 yaeggilRALIITPTRELALQVtdHLKEVAKGTN--VRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhL 314
Cdd:PRK04537 86 -------RALILAPTRELAIQI--HKDAVKFGADlgLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHK--V 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 315 VELHSLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniQRKKRQTFVFSATIalsadfrkkl 394
Cdd:PRK04537 155 VSLHACEICVLDEADRMFDLGFIKDIRFLLRRMP----------------------ERGTRQTLLFSATL---------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 395 krgALRSKQLMNDGLNSIETLSERAgmrpnaaivdltnASIMANKLEESFIECREEDKDAYLYYILSVHGQGRTIVFCTS 474
Cdd:PRK04537 203 ---SHRVLELAYEHMNEPEKLVVET-------------ETITAARVRQRIYFPADEEKQTLLLGLLSRSEGARTMVFVNT 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 475 IAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSG 554
Cdd:PRK04537 267 KAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIG 346
|
410
....*....|....
gi 225433316 555 RTARASADGCSIAL 568
Cdd:PRK04537 347 RTARLGEEGDAISF 360
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
166-383 |
2.08e-53 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 183.61 E-value: 2.08e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEerekaaeplaenseeKYAEGGILRA 245
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLAL-LGKDICASAVTGSGKTAAFLLPILERLLY---------------RPKKKAATRV 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWelmsrgeDHL-----VELHSL 320
Cdd:cd17947 65 LVLVPTRELAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLI-------DHLrnspsFDLDSI 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225433316 321 SFFVLDEADRMVENGHFHELQSIIDILPKTsgsmeslsqntencftvsniqrkkRQTFVFSAT 383
Cdd:cd17947 138 EILVLDEADRMLEEGFADELKEILRLCPRT------------------------RQTMLFSAT 176
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
166-383 |
2.91e-51 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 178.28 E-value: 2.91e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEerekaaepLAENSEEKYAEGGilRA 245
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGL-QNRDIIGIAETGSGKTAAFLIPLLVYISR--------LPPLDEETKDDGP--YA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMsrgEDHLVELHSLSFFVL 325
Cdd:cd17945 70 LILAPTRELAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCL---ERRLLVLNQCTYVVL 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 225433316 326 DEADRMVENGHFHELQSIIDILPKTSGSMESLSQNTENcftvSNIQRKKRQTFVFSAT 383
Cdd:cd17945 147 DEADRMIDMGFEPQVTKILDAMPVSNKKPDTEEAEKLA----ASGKHRYRQTMMFTAT 200
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
160-569 |
2.17e-50 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 183.47 E-value: 2.17e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 160 LRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLleerekaaeplaeNSEEKYAE 239
Cdd:PRK10590 6 LGLSPDILRAVAEQGYREPTPIQQQAIPAVL-EGRDLMASAQTGTGKTAGFTLPLLQHL-------------ITRQPHAK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 240 GG-ILRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRgedHLVELH 318
Cdd:PRK10590 72 GRrPVRALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQ---NAVKLD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 319 SLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATialsadFRKKLKrgA 398
Cdd:PRK10590 149 QVEILVLDEADRMLDMGFIHDIRRVLAKLP------------------------AKRQNLLFSAT------FSDDIK--A 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 399 LRSKQLMNDglNSIETlseragMRPNAAIVDLTNASIMANKleesfiecreEDKDAYLYYILSVHGQGRTIVFCTSIAAL 478
Cdd:PRK10590 197 LAEKLLHNP--LEIEV------ARRNTASEQVTQHVHFVDK----------KRKRELLSQMIGKGNWQQVLVFTRTKHGA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 479 RHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTAR 558
Cdd:PRK10590 259 NHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGR 338
|
410
....*....|.
gi 225433316 559 ASADGCSIALI 569
Cdd:PRK10590 339 AAATGEALSLV 349
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
157-392 |
9.54e-50 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 173.64 E-value: 9.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLleereKAAEPlaenseek 236
Cdd:cd17959 3 FQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLIL-DGRDVVAMARTGSGKTAAFLIPMIEKL-----KAHSP-------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 237 yaEGGIlRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSrgEDHLvE 316
Cdd:cd17959 69 --TVGA-RALILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLV--EMNL-K 142
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225433316 317 LHSLSFFVLDEADRMVENGHFHELQSIIDILPKTsgsmeslsqntencftvsniqrkkRQTFVFSATI-ALSADFRK 392
Cdd:cd17959 143 LSSVEYVVFDEADRLFEMGFAEQLHEILSRLPEN------------------------RQTLLFSATLpKLLVEFAK 195
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
440-569 |
1.59e-49 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 170.38 E-value: 1.59e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 440 LEESFIECREEDKDAYLY-YILSVHGQGRTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGI 518
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 225433316 519 LVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTARASADGCSIALI 569
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
166-595 |
2.02e-48 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 179.97 E-value: 2.02e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLeerekaAEPLAenseeKYAEGGILra 245
Cdd:PTZ00110 141 ILKSLKNAGFTEPTPIQVQGWPIAL-SGRDMIGIAETGSGKTLAFLLPAIVHIN------AQPLL-----RYGDGPIV-- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMsrgEDHLVELHSLSFFVL 325
Cdd:PTZ00110 207 LVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFL---ESNVTNLRRVTYLVL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 326 DEADRMVENGHFHELQSIidilpktsgsmeslsqntencftVSNIqRKKRQTFVFSAT-----IALSADfrkklkrgalr 400
Cdd:PTZ00110 284 DEADRMLDMGFEPQIRKI-----------------------VSQI-RPDRQTLMWSATwpkevQSLARD----------- 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 401 skqlmndglnsietLSERAGMRPNAAIVDLTNASimaNKLEESFIeCREEDKDAYLYYILS--VHGQGRTIVFCTSIAAL 478
Cdd:PTZ00110 329 --------------LCKEEPVHVNVGSLDLTACH---NIKQEVFV-VEEHEKRGKLKMLLQriMRDGDKILIFVETKKGA 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 479 RHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTAR 558
Cdd:PTZ00110 391 DFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGR 470
|
410 420 430
....*....|....*....|....*....|....*..
gi 225433316 559 ASADGCSIALISPnDRSKFANLCKSFSKESFQRFPIE 595
Cdd:PTZ00110 471 AGAKGASYTFLTP-DKYRLARDLVKVLREAKQPVPPE 506
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
162-401 |
2.18e-47 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 166.99 E-value: 2.18e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 162 LHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAEPLAenseekyaegg 241
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLAL-EGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQG----------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 242 iLRALIITPTRELALQVTDHLKEVAKGTN--VRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhLVELHS 319
Cdd:cd17961 69 -TRALILVPTRELAQQVSKVLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGS--LLLLST 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 320 LSFFVLDEADRMVENGHFHELQSIIDILPKtsgsmeslsqnteNCftvsniqrkkrQTFVFSATiaLSADFRkKLKRGAL 399
Cdd:cd17961 146 LKYLVIDEADLVLSYGYEEDLKSLLSYLPK-------------NY-----------QTFLMSAT--LSEDVE-ALKKLVL 198
|
..
gi 225433316 400 RS 401
Cdd:cd17961 199 HN 200
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
159-580 |
3.14e-47 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 178.12 E-value: 3.14e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 159 ELRLHPLLMKSIHRLGFKQPTPIQKACIPaaaH--QGKDVVGASETGSGKTLALGLPILQRLLEErekaaeplaenseek 236
Cdd:PRK11634 10 DLGLKAPILEALNDLGYEKPSPIQAECIP---HllNGRDVLGMAQTGSGKTAAFSLPLLHNLDPE--------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 237 yaeggiLRA---LIITPTRELALQVTDHLKEVAKGTN-VRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEd 312
Cdd:PRK11634 72 ------LKApqiLVLAPTRELAVQVAEAMTDFSKHMRgVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGT- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 313 hlVELHSLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATIAlsadfrk 392
Cdd:PRK11634 145 --LDLSKLSGLVLDEADEMLRMGFIEDVETIMAQIP------------------------EGHQTALFSATMP------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 393 klkrGALR--SKQLMNDG-----LNSIETLSERA-------GMRPNAAIVdltnasimankleeSFIECreEDKDAylyy 458
Cdd:PRK11634 192 ----EAIRriTRRFMKEPqevriQSSVTTRPDISqsywtvwGMRKNEALV--------------RFLEA--EDFDA---- 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 459 ilsvhgqgrTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVV 538
Cdd:PRK11634 248 ---------AIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVV 318
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 225433316 539 HYQLPHSAEVYVHRSGRTARASADGCSIALISPNDRSKFANL 580
Cdd:PRK11634 319 NYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNI 360
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
166-384 |
1.85e-45 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 161.59 E-value: 1.85e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLeerekaaeplaenSEEKYAEGGILRA 245
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFL-SNKDVVVEAVTGSGKTLAFLIPVLEILL-------------KRKANLKKGQVGA 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAK--GTNVRVVPIVGGMSTEKQ-ERLLKARPEIVVGTPGRLWELMSRgEDHLVELHSLSF 322
Cdd:cd17960 67 LIISPTRELATQIYEVLQSFLEhhLPKLKCQLLIGGTNVEEDvKKFKRNGPNILVGTPGRLEELLSR-KADKVKVKSLEV 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225433316 323 FVLDEADRMVENGHFHELQSIIDILPKTsgsmeslsqntencftvsniqrkkRQTFVFSATI 384
Cdd:cd17960 146 LVLDEADRLLDLGFEADLNRILSKLPKQ------------------------RRTGLFSATQ 183
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
159-568 |
1.87e-45 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 168.61 E-value: 1.87e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 159 ELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEErekaaePLAENSEEKYA 238
Cdd:PRK04837 12 DFALHPQVVEALEKKGFHNCTPIQALALPLTL-AGRDVAGQAQTGTGKTMAFLTATFHYLLSH------PAPEDRKVNQP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 239 eggilRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGedhLVELH 318
Cdd:PRK04837 85 -----RALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQN---HINLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 319 SLSFFVLDEADRMVENGHFHELQSIIDILPKTsgsmeslsqntencftvsniqrKKRQTFVFSATiaLSadfrkklkrga 398
Cdd:PRK04837 157 AIQVVVLDEADRMFDLGFIKDIRWLFRRMPPA----------------------NQRLNMLFSAT--LS----------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 399 LRSKQLMNDGLNSIETLSeragMRPNAAivdlTNASIManklEESFIEcREEDKDAYLYYILSVHGQGRTIVF------C 472
Cdd:PRK04837 202 YRVRELAFEHMNNPEYVE----VEPEQK----TGHRIK----EELFYP-SNEEKMRLLQTLIEEEWPDRAIIFantkhrC 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 473 TSIAAlrHtsslLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHR 552
Cdd:PRK04837 269 EEIWG--H----LAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHR 342
|
410
....*....|....*.
gi 225433316 553 SGRTARASADGCSIAL 568
Cdd:PRK04837 343 IGRTGRAGASGHSISL 358
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
159-390 |
2.05e-45 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 162.27 E-value: 2.05e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 159 ELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEE-------REKAAEPlae 231
Cdd:cd17967 4 EAGLRELLLENIKRAGYTKPTPVQKYAIPIIL-AGRDLMACAQTGSGKTAAFLLPIISKLLEDgppsvgrGRRKAYP--- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 232 nseekyaeggilRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGe 311
Cdd:cd17967 80 ------------SALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERG- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 312 dhLVELHSLSFFVLDEADRMVENGHFHELQSIIDilpktSGSMESLSQntencftvsniqrkkRQTFVFSATIA-----L 386
Cdd:cd17967 147 --RISLSSIKFLVLDEADRMLDMGFEPQIRKIVE-----HPDMPPKGE---------------RQTLMFSATFPreiqrL 204
|
....
gi 225433316 387 SADF 390
Cdd:cd17967 205 AADF 208
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
179-389 |
6.44e-45 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 158.56 E-value: 6.44e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 179 TPIQKACIPAAaHQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseekyaeggiLRALIITPTRELALQV 258
Cdd:pfam00270 1 TPIQAEAIPAI-LEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNG------------------PQALVLAPTRELAEQI 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 259 TDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKaRPEIVVGTPGRLWELMsrgeDHLVELHSLSFFVLDEADRMVENGHFH 338
Cdd:pfam00270 62 YEELKKLGKGLGLKVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLL----QERKLLKNLKLLVLDEAHRLLDMGFGP 136
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 225433316 339 ELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATIALSAD 389
Cdd:pfam00270 137 DLEEILRRLP------------------------KKRQILLLSATLPRNLE 163
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
162-384 |
2.91e-44 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 158.52 E-value: 2.91e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 162 LHPLLMKSIHRLGFKQPTPIQKACIPAAAHQGKDVVGASETGSGKTLALGLPILQRLLEerekaaEPLAENSeekyaeGG 241
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTGDDVLARAKTGTGKTLAFLLPAIQSLLN------TKPAGRR------SG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 242 IlRALIITPTRELALQVTDHLKEVAKG-TNVRVVPIVGGMSTEKQE-RLLKARPEIVVGTPGRLwelmsrgEDHL----- 314
Cdd:cd17964 69 V-SALIISPTRELALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAELnRLRRGRPDILVATPGRL-------IDHLenpgv 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225433316 315 -VELHSLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsNIQRKKRQTFVFSATI 384
Cdd:cd17964 141 aKAFTDLDYLVLDEADRLLDMGFRPDLEQILRHLP--------------------EKNADPRQTLLFSATV 191
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
157-383 |
1.40e-42 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 154.07 E-value: 1.40e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEERekaaePLAEnseek 236
Cdd:cd17953 14 WSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIM-SGRDVIGIAKTGSGKTLAFLLPMFRHIKDQR-----PVKP----- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 237 yAEGGIlrALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEDHLVE 316
Cdd:cd17953 83 -GEGPI--GLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNGRVTN 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225433316 317 LHSLSFFVLDEADRMVENGHFHELQSIIDilpktsgsmeslsqntencftvsNIqRKKRQTFVFSAT 383
Cdd:cd17953 160 LRRVTYVVLDEADRMFDMGFEPQIMKIVN-----------------------NI-RPDRQTVLFSAT 202
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
162-580 |
2.93e-42 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 161.49 E-value: 2.93e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 162 LHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRL----LEEREKAAEPLAenseeky 237
Cdd:PLN00206 128 LPPKLLLNLETAGYEFPTPIQMQAIPAAL-SGRSLLVSADTGSGKTASFLVPIISRCctirSGHPSEQRNPLA------- 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 238 aeggilraLIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRgedHLVEL 317
Cdd:PLN00206 200 --------MVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSK---HDIEL 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 318 HSLSFFVLDEADRMVENGHFHELQSIIdilpktsgsmESLSQNtencftvsniqrkkrQTFVFSATIALSADfrkklKRG 397
Cdd:PLN00206 269 DNVSVLVLDEVDCMLERGFRDQVMQIF----------QALSQP---------------QVLLFSATVSPEVE-----KFA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 398 ALRSKQLMndgLNSIETLSeragmRPNAAIVDLTnasimankleesfIECREEDKDAYLYYIL--SVHGQGRTIVFCTS- 474
Cdd:PLN00206 319 SSLAKDII---LISIGNPN-----RPNKAVKQLA-------------IWVETKQKKQKLFDILksKQHFKPPAVVFVSSr 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 475 IAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSG 554
Cdd:PLN00206 378 LGADLLANAITVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIG 457
|
410 420
....*....|....*....|....*.
gi 225433316 555 RTARASADGCSIALISPNDRSKFANL 580
Cdd:PLN00206 458 RASRMGEKGTAIVFVNEEDRNLFPEL 483
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
158-392 |
1.65e-41 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 152.81 E-value: 1.65e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 158 NELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAEplaenseekY 237
Cdd:cd18052 46 EEANLCETLLKNIRKAGYEKPTPVQKYAIPIIL-AGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASS---------F 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 238 AEGGILRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVEL 317
Cdd:cd18052 116 SEVQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGK---ISL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 318 HSLSFFVLDEADRMVENGHFHELQSIIdilpkTSGSMESlsqntencftvsniqRKKRQTFVFSATIA-----LSADFRK 392
Cdd:cd18052 193 SKLKYLILDEADRMLDMGFGPEIRKLV-----SEPGMPS---------------KEDRQTLMFSATFPeeiqrLAAEFLK 252
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
168-383 |
1.31e-39 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 145.13 E-value: 1.31e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 168 KSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEERekaaeplaenseekYAEGGILRALI 247
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHAL-QGRDILGAAKTGSGKTLAFLVPLLEKLYRER--------------WTPEDGLGALI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 248 ITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTeKQERLLKARPEIVVGTPGRLWELMSrgEDHLVELHSLSFFVLDE 327
Cdd:cd17941 68 ISPTRELAMQIFEVLRKVGKYHSFSAGLIIGGKDV-KEEKERINRMNILVCTPGRLLQHMD--ETPGFDTSNLQMLVLDE 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 225433316 328 ADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSAT 383
Cdd:cd17941 145 ADRILDMGFKETLDAIVENLP------------------------KSRQTLLFSAT 176
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
170-394 |
6.22e-39 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 143.02 E-value: 6.22e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 170 IHRLGFKQPTPIQKACIPAAAHQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseekyaeggilRALIIT 249
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGG-------------------RVLVLV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 250 PTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQ-ERLLKARPEIVVGTPGRlweLMSRGEDHLVELHSLSFFVLDEA 328
Cdd:smart00487 62 PTRELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQlRKLESGKTDILVTTPGR---LLDLLENDKLSLSNVDLVILDEA 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225433316 329 DRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATIALSADFRKKL 394
Cdd:smart00487 139 HRLLDGGFGDQLEKLLKLLP------------------------KNVQLLLLSATPPEEIENLLEL 180
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
166-398 |
1.12e-38 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 142.17 E-value: 1.12e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseeKYAEGGIlrA 245
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVAL-SGRDMIGIAKTGSGKTAAFIWPMLVHIMDQREL-----------EKGEGPI--A 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVELHSLSFFVL 325
Cdd:cd17952 67 VIVAPTRELAQQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKA---TNLQRVTYLVL 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225433316 326 DEADRMVENGHFHELQSIIDILpktsgsmeslsqntencftvsniqRKKRQTFVFSATialsadFRKKLKRGA 398
Cdd:cd17952 144 DEADRMFDMGFEYQVRSIVGHV------------------------RPDRQTLLFSAT------FKKKIEQLA 186
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
159-394 |
1.51e-38 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 142.07 E-value: 1.51e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 159 ELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQrlleerekaaeplaenseekya 238
Cdd:cd17938 3 ELGVMPELIKAVEELDWLLPTDIQAEAIPLIL-GGGDVLMAAETGSGKTGAFCLPVLQ---------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 239 eggILRALIITPTRELALQVTDHLKEVAK---GTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGedhLV 315
Cdd:cd17938 60 ---IVVALILEPSRELAEQTYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTG---KL 133
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225433316 316 ELHSLSFFVLDEADRMVENGHFHELQSIIDILPKTSGSMESLsqntencftvsniqrkkrQTFVFSATiaLSADFRKKL 394
Cdd:cd17938 134 DLSSVRFFVLDEADRLLSQGNLETINRIYNRIPKITSDGKRL------------------QVIVCSAT--LHSFEVKKL 192
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
166-392 |
1.45e-36 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 136.35 E-value: 1.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLleerekAAEPLAENSEekyaeGGIlrA 245
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMAL-SGRDMVGIAQTGSGKTLAFLLPAIVHI------NAQPPLERGD-----GPI--V 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVELHSLSFFVL 325
Cdd:cd17966 67 LVLAPTRELAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGK---TNLRRVTYLVL 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225433316 326 DEADRMVENGHFHELQSIIDILpktsgsmeslsqntencftvsniqRKKRQTFVFSAT-----IALSADFRK 392
Cdd:cd17966 144 DEADRMLDMGFEPQIRKIVDQI------------------------RPDRQTLMWSATwpkevRRLAEDFLK 191
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
166-389 |
6.40e-36 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 135.45 E-value: 6.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAHQGK--------DVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseeky 237
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSSKstppyrpgDLCVSAPTGSGKTLAYVLPIVQALSKRVVP------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 238 aeggILRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKA--------RPEIVVGTPGRLwelmsr 309
Cdd:cd17956 68 ----RLRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVdtsgrylsRVDILVATPGRL------ 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 310 gEDHLVE-----LHSLSFFVLDEADRMVENGHfhelQSIIDILPKTSGSMESLSQNTENCFTVSNIQRKKRQTFVFSATi 384
Cdd:cd17956 138 -VDHLNStpgftLKHLRFLVIDEADRLLNQSF----QDWLETVMKALGRPTAPDLGSFGDANLLERSVRPLQKLLFSAT- 211
|
....*
gi 225433316 385 aLSAD 389
Cdd:cd17956 212 -LTRD 215
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
166-335 |
2.49e-35 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 132.71 E-value: 2.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAaHQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAeplaenseekyaeggiLRA 245
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPIL-LHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKKKG----------------LRA 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMS-TEKQERLLKARPEIVVGTPGRLWELMSRGedhLVELHSLSFFV 324
Cdd:cd17957 64 LILAPTRELASQIYRELLKLSKGTGLRIVLLSKSLEaKAKDGPKSITKYDILVSTPLRLVFLLKQG---PIDLSSVEYLV 140
|
170
....*....|.
gi 225433316 325 LDEADRMVENG 335
Cdd:cd17957 141 LDEADKLFEPG 151
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
128-587 |
6.46e-34 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 134.57 E-value: 6.46e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 128 NQTNEESATVSNDkDDVEGDSVDEAEFYEwnELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKT 207
Cdd:PTZ00424 4 SEQKNQSEQVAST-GTIESNYDEIVDSFD--ALKLNEDLLRGIYSYGFEKPSAIQQRGIKPIL-DGYDTIGQAQSGTGKT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 208 LALGLPILQRLleerekaaEPLAENSEekyaeggilrALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQER 287
Cdd:PTZ00424 80 ATFVIAALQLI--------DYDLNACQ----------ALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDIN 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 288 LLKARPEIVVGTPGRLWELMSRGedHLvELHSLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftv 367
Cdd:PTZ00424 142 KLKAGVHMVVGTPGRVYDMIDKR--HL-RVDDLKLFILDEADEMLSRGFKGQIYDVFKKLP------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 368 SNIQrkkrqTFVFSAT-----IALSADFRKKLKRGALRSKQLMNDGLNSIetlseragmrpnaaivdltnaSIMANKLEE 442
Cdd:PTZ00424 200 PDVQ-----VALFSATmpneiLELTTKFMRDPKRILVKKDELTLEGIRQF---------------------YVAVEKEEW 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 443 SFiecreeDKDAYLYYILSVhgqGRTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVAT 522
Cdd:PTZ00424 254 KF------DTLCDLYETLTI---TQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITT 324
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225433316 523 DVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTARASADGCSIALISPNDRSKFANLCKSFSKE 587
Cdd:PTZ00424 325 DLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQ 389
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
157-393 |
1.50e-33 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 127.80 E-value: 1.50e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLleerekaaeplaeNSEEK 236
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIAL-SGRDILARAKNGTGKTGAYLIPILEKI-------------DPKKD 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 237 YaeggiLRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVE 316
Cdd:cd17940 67 V-----IQALILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGV---AD 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225433316 317 LHSLSFFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATIALSA-DFRKK 393
Cdd:cd17940 139 LSHCKTLVLDEADKLLSQDFQPIIEKILNFLP------------------------KERQILLFSATFPLTVkNFMDR 192
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
167-383 |
1.39e-32 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 124.78 E-value: 1.39e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 167 MKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAEPLAenseekyaeggilrAL 246
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLL-EGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTG--------------VI 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 247 IITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMS-TEKQERLLKARPeIVVGTPGRLWELMSRGEDHLVelHSLSFFVL 325
Cdd:cd17942 67 IISPTRELALQIYGVAKELLKYHSQTFGIVIGGANrKAEAEKLGKGVN-ILVATPGRLLDHLQNTKGFLY--KNLQCLII 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 225433316 326 DEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSAT 383
Cdd:cd17942 144 DEADRILEIGFEEEMRQIIKLLP------------------------KRRQTMLFSAT 177
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
166-384 |
2.15e-32 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 124.20 E-value: 2.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAeplaenseekyaeggilrA 245
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGL-LGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPS------------------A 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGT-NVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRgedHLVELHSLSFFV 324
Cdd:cd17962 62 LILTPTRELAVQIEDQAKELMKGLpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQ---SSVELDNIKIVV 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 325 LDEADRMVENGhFHelQSIIDILpktsgsmESLSQNtencftvsniqrkkRQTFVFSATI 384
Cdd:cd17962 139 VDEADTMLKMG-FQ--QQVLDIL-------ENISHD--------------HQTILVSATI 174
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
451-559 |
1.54e-31 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 118.85 E-value: 1.54e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 451 DKDAYLYYILSVHGQGRTIVFCTSIAALrHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLD 530
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTL-EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100
....*....|....*....|....*....
gi 225433316 531 IPGVRTVVHYQLPHSAEVYVHRSGRTARA 559
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRA 108
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
156-390 |
1.23e-30 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 120.92 E-value: 1.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 156 EWNELRLHPLLMKSIHRLGFKQPTPIQKACIPAAaHQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAEPLAE---N 232
Cdd:cd18051 22 TFSDLDLGEIIRNNIELARYTKPTPVQKHAIPII-KSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGESLPSESgyyG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 233 SEEKYAEggilrALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEd 312
Cdd:cd18051 101 RRKQYPL-----ALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGK- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 313 hlVELHSLSFFVLDEADRMVENGHFHELQSII--DILPKTSgsmeslsqntencftvsniqrkKRQTFVFSATI-----A 385
Cdd:cd18051 175 --IGLDYCKYLVLDEADRMLDMGFEPQIRRIVeqDTMPPTG----------------------ERQTLMFSATFpkeiqM 230
|
....*
gi 225433316 386 LSADF 390
Cdd:cd18051 231 LARDF 235
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
172-384 |
2.07e-30 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 119.23 E-value: 2.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 172 RLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLeerekAAEPLAENSEekyaegGILrALIITPT 251
Cdd:cd17949 8 KMGIEKPTAIQKLAIPVLL-QGRDVLVRSQTGSGKTLAYLLPIIQRLL-----SLEPRVDRSD------GTL-ALVLVPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 252 RELALQVTDHLKEVAKGTnVRVVP--IVGGMS--TEKQeRLLKARPeIVVGTPGRLWelmsrgeDHL-----VELHSLSF 322
Cdd:cd17949 75 RELALQIYEVLEKLLKPF-HWIVPgyLIGGEKrkSEKA-RLRKGVN-ILIATPGRLL-------DHLkntqsFDVSNLRW 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225433316 323 FVLDEADRMVENGhFHElqSIIDILpktsgsmESLSQNTENCFTVSNIQrKKRQTFVFSATI 384
Cdd:cd17949 145 LVLDEADRLLDMG-FEK--DITKIL-------ELLDDKRSKAGGEKSKP-SRRQTVLVSATL 195
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
166-384 |
5.23e-30 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 117.36 E-value: 5.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseekyaeggiLRA 245
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGL-AGHDLIVQAKSGTGKTLVFVVIALESLDLERRH------------------PQV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVA-KGTNVRVVPIVGGMSTEKQERLLKaRPEIVVGTPGRLwelmsrgeDHLVELHSLS--- 321
Cdd:cd17943 62 LILAPTREIAVQIHDVFKKIGkKLEGLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRI--------KQLIELGALNvsh 132
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225433316 322 --FFVLDEADRMVENGHFHELQSIIDILPktsgsmeslsqntencftvsniqrKKRQTFVFSATI 384
Cdd:cd17943 133 vrLFVLDEADKLMEGSFQKDVNWIFSSLP------------------------KNKQVIAFSATY 173
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
166-356 |
1.57e-29 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 116.02 E-value: 1.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEE---REKAAEPlaenseekyaeggi 242
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIIL-QGIDLIGVAQTGTGKTLAYLLPGFIHLDLQpipREQRNGP-------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 243 lRALIITPTRELALQVTDHLKEVaKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSrgeDHLVELHSLSF 322
Cdd:cd17958 66 -GVLVLTPTRELALQIEAECSKY-SYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQM---NNVINLKSITY 140
|
170 180 190
....*....|....*....|....*....|....*
gi 225433316 323 FVLDEADRMVENGHFHELQSI-IDILPKTSGSMES 356
Cdd:cd17958 141 LVLDEADRMLDMGFEPQIRKIlLDIRPDRQTIMTS 175
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
166-350 |
2.06e-29 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 117.08 E-value: 2.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAaHQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAEPLaeNSEekyaeggilRA 245
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSI-LRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPF--NAP---------RG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSteKQERLLKARPE--IVVGTPGRLWELMSRgedHLVELHSLSFF 323
Cdd:cd17948 69 LVITPSRELAEQIGSVAQSLTEGLGLKVKVITGGRT--KRQIRNPHFEEvdILVATPGALSKLLTS---RIYSLEQLRHL 143
|
170 180
....*....|....*....|....*..
gi 225433316 324 VLDEADRMVENGhFHELQSiiDILPKT 350
Cdd:cd17948 144 VLDEADTLLDDS-FNEKLS--HFLRRF 167
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
159-350 |
3.28e-29 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 115.11 E-value: 3.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 159 ELRLHPLLMKSIHRLGFKQPTPIQKACI-PAAahQGKDVVGASETGSGKTLALGLPILQRLleerekaaeplaENSEEKy 237
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIvPII--KGRDVIAQAQSGTGKTATFSIGALQRI------------DTTVRE- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 238 aeggiLRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVEL 317
Cdd:cd17939 66 -----TQALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRS---LRT 137
|
170 180 190
....*....|....*....|....*....|...
gi 225433316 318 HSLSFFVLDEADRMVENGHFHELQSIIDILPKT 350
Cdd:cd17939 138 DKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPE 170
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
166-384 |
9.49e-28 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 111.28 E-value: 9.49e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLLEEREKAaePLAENseekyaEGGIlrA 245
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTIL-SGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKL--PFIKG------EGPY--G 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTN------VRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVELHS 319
Cdd:cd17951 70 LIVCPSRELARQTHEVIEYYCKALQeggypqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKK---INLDI 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225433316 320 LSFFVLDEADRMVENGHFHELQSIIDIlpktsgsmeslsqntencFTvsniqrKKRQTFVFSATI 384
Cdd:cd17951 147 CRYLCLDEADRMIDMGFEEDIRTIFSY------------------FK------GQRQTLLFSATM 187
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
162-333 |
4.71e-26 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 106.66 E-value: 4.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 162 LHPLLMKSIHRLGFKQPTPIQKACIPAAAHqGKDVVGASETGSGKTLALGLPILQRLleerekaaEPlaenseekyaEGG 241
Cdd:cd17950 9 LKPELLRAIVDCGFEHPSEVQHECIPQAIL-GMDVLCQAKSGMGKTAVFVLSTLQQL--------EP----------VDG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 242 ILRALIITPTRELALQVTDHLKEVAKG-TNVRVVPIVGGMSTEKQERLLKAR-PEIVVGTPGRLWELMSRGEdhlVELHS 319
Cdd:cd17950 70 QVSVLVICHTRELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLKNKcPHIVVGTPGRILALVREKK---LKLSH 146
|
170
....*....|....
gi 225433316 320 LSFFVLDEADRMVE 333
Cdd:cd17950 147 VKHFVLDECDKMLE 160
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
157-350 |
6.99e-26 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 105.99 E-value: 6.99e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQK-ACIPAAahQGKDVVGASETGSGKTLALGLPILQRLlEEREKAAEplaensee 235
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQrAIMPCI--KGYDVIAQAQSGTGKTATFSISILQQI-DTSLKATQ-------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 236 kyaeggilrALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGedhLV 315
Cdd:cd18046 70 ---------ALVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRR---YL 137
|
170 180 190
....*....|....*....|....*....|....*
gi 225433316 316 ELHSLSFFVLDEADRMVENGHFHELQSIIDILPKT 350
Cdd:cd18046 138 RTDYIKMFVLDEADEMLSRGFKDQIYDIFQKLPPD 172
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
153-392 |
1.19e-25 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 106.25 E-value: 1.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 153 EFYEWNelrLHPLLMKSIHRLGFKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLleerekAAEPLAEN 232
Cdd:cd18049 25 NFYEAN---FPANVMDVIARQNFTEPTAIQAQGWPVAL-SGLDMVGVAQTGSGKTLSYLLPAIVHI------NHQPFLER 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 233 seekyAEGGILraLIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEd 312
Cdd:cd18049 95 -----GDGPIC--LVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 313 hlVELHSLSFFVLDEADRMVENGHFHELQSIIDILpktsgsmeslsqntencftvsniqRKKRQTFVFSATI-----ALS 387
Cdd:cd18049 167 --TNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQI------------------------RPDRQTLMWSATWpkevrQLA 220
|
....*
gi 225433316 388 ADFRK 392
Cdd:cd18049 221 EDFLK 225
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
162-383 |
1.88e-24 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 101.50 E-value: 1.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 162 LHPLLMKSIHRLGFKQPTPIQKACIPAA-AHQGKDVVGASETGSGKTLALGLPILQRLlEEREKAaeplaenseekyaeg 240
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLIlSDPPENLIAQSQSGTGKTAAFVLAMLSRV-DPTLKS--------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 241 giLRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQErllKARPEIVVGTPGRLWELMSRgedHLVELHSL 320
Cdd:cd17963 65 --PQALCLAPTRELARQIGEVVEKMGKFTGVKVALAVPGNDVPRGK---KITAQIVIGTPGTVLDWLKK---RQLDLKKI 136
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225433316 321 SFFVLDEADRMVE-NGHFHELQSIIDILPKtsgsmeslsqnteNCftvsniqrkkrQTFVFSAT 383
Cdd:cd17963 137 KILVLDEADVMLDtQGHGDQSIRIKRMLPR-------------NC-----------QILLFSAT 176
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
158-349 |
3.40e-24 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 102.45 E-value: 3.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 158 NELRLHP---------LLMKSIHRLGFKQPTPIQKACIPA--------AAHQGKDVVG-------ASETGSGKTLALGLP 213
Cdd:cd17965 2 DQLKLLPsvreaiikeILKGSNKTDEEIKPSPIQTLAIKKllktlmrkVTKQTSNEEPklevfllAAETGSGKTLAYLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 214 ILQRLLEErEKAAEPLAENSEEKYAEGGILRALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLL--KA 291
Cdd:cd17965 82 LLDYLKRQ-EQEPFEEAEEEYESAKDTGRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLafKG 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 225433316 292 RPEIVVGTPGRlweLMSRGEDHLVELHSLSFFVLDEADRMVENGHFHELQSIIDILPK 349
Cdd:cd17965 161 RIDILVTTPGK---LASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPK 215
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
484-559 |
4.01e-24 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 96.51 E-value: 4.01e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225433316 484 LLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTARA 559
Cdd:smart00490 6 LLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
175-383 |
2.09e-22 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 97.77 E-value: 2.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 175 FKQPTPIQKACIPAAAhQGKDVVGASETGSGKTLALGLPILQRLleerekAAEPLAENseekyAEGGIlrALIITPTREL 254
Cdd:cd18050 82 FKEPTPIQCQGFPLAL-SGRDMVGIAQTGSGKTLAYLLPAIVHI------NHQPYLER-----GDGPI--CLVLAPTREL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 255 ALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVELHSLSFFVLDEADRMVEN 334
Cdd:cd18050 148 AQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK---TNLRRCTYLVLDEADRMLDM 224
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 225433316 335 GHFHELQSIIDILpktsgsmeslsqntencftvsniqRKKRQTFVFSAT 383
Cdd:cd18050 225 GFEPQIRKIVDQI------------------------RPDRQTLMWSAT 249
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
180-383 |
1.19e-20 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 90.68 E-value: 1.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 180 PIQKACIpAAAHQGKDVVGASETGSGKTLALGLPILQRL---LEEREKAAEPlaenseekyaeggilRALIITPTRELAL 256
Cdd:cd17944 15 PIQVKTF-HPVYSGKDLIAQARTGTGKTFSFAIPLIEKLqedQQPRKRGRAP---------------KVLVLAPTRELAN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 257 QVTDHLKEVAKGTNVRVvpIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVELHSLSFFVLDEADRMVENGH 336
Cdd:cd17944 79 QVTKDFKDITRKLSVAC--FYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGR---LDLTKLKHVVLDEVDQMLDMGF 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 225433316 337 FHELQSIIDilpktsgsmESLSQNTENcftvsniqrkKRQTFVFSAT 383
Cdd:cd17944 154 AEQVEEILS---------VSYKKDSED----------NPQTLLFSAT 181
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
166-348 |
2.69e-20 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 89.83 E-value: 2.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQK-ACIPAAahQGKDVVGASETGSGKTLALGLPILQRL-LEEREkaaeplaenseekyaeggiL 243
Cdd:cd18045 10 LLRGIYAYGFEKPSAIQQrAIKPII--KGRDVIAQSQSGTGKTATFSISVLQCLdIQVRE-------------------T 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 244 RALIITPTRELALQVTDHLKEVAKGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhlVELHSLSFF 323
Cdd:cd18045 69 QALILSPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRS---LRTRHIKML 145
|
170 180
....*....|....*....|....*
gi 225433316 324 VLDEADRMVENGHFHELQSIIDILP 348
Cdd:cd18045 146 VLDEADEMLNKGFKEQIYDVYRYLP 170
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
193-338 |
4.56e-20 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 87.46 E-value: 4.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 193 GKDVVGASETGSGKTLALGLPILQRLLEERekaaeplaenseekyaeggiLRALIITPTRELALQVTDHLKEVAKGtNVR 272
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKKG--------------------KKVLVLVPTKALALQTAERLRELFGP-GIR 59
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225433316 273 VVPIVGGMSTEKQERLLKARPEIVVGTPGRLweLMSRGEDHLVELHSLSFFVLDEADRMVENGHFH 338
Cdd:cd00046 60 VAVLVGGSSAEEREKNKLGDADIIIATPDML--LNLLLREDRLFLKDLKLIIVDEAHALLIDSRGA 123
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
157-350 |
3.50e-19 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 87.38 E-value: 3.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAA-AHQGKDVVGASETGSGKTLALGLPILQRLleerekaaeplaeNSEE 235
Cdd:cd18048 20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMlADPPQNLIAQSQSGTGKTAAFVLAMLSRV-------------DALK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 236 KYAEggilrALIITPTRELALQVTDHLKEVAKGTN-VRVVPIVGGMSTEKQERLLKarpEIVVGTPGRL--WELMSRged 312
Cdd:cd18048 87 LYPQ-----CLCLSPTFELALQTGKVVEEMGKFCVgIQVIYAIRGNRPGKGTDIEA---QIVIGTPGTVldWCFKLR--- 155
|
170 180 190
....*....|....*....|....*....|....*....
gi 225433316 313 hLVELHSLSFFVLDEADRMVE-NGHFHELQSIIDILPKT 350
Cdd:cd18048 156 -LIDVTNISVFVLDEADVMINvQGHSDHSVRVKRSMPKE 193
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
157-349 |
4.81e-17 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 80.53 E-value: 4.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 157 WNELRLHPLLMKSIHRLGFKQPTPIQKACIPAA-AHQGKDVVGASETGSGKTLALGLPILQRLleerekaaEPLAENSEe 235
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMlAEPPQNLIAQSQSGTGKTAAFVLAMLSQV--------EPANKYPQ- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 236 kyaeggilrALIITPTRELALQVTDHLKEVakGTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEdhLV 315
Cdd:cd18047 74 ---------CLCLSPTYELALQTGKVIEQM--GKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLK--FI 140
|
170 180 190
....*....|....*....|....*....|....*
gi 225433316 316 ELHSLSFFVLDEADRMV-ENGHFHELQSIIDILPK 349
Cdd:cd18047 141 DPKKIKVFVLDEADVMIaTQGHQDQSIRIQRMLPR 175
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
443-611 |
1.11e-15 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 80.57 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 443 SFIECREEDKDAYLYYILSVHGQGRTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVAT 522
Cdd:COG0514 208 EVVPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 523 dVA-ARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTARASADGCSIALISPNDRSKfanlcksfskesfQRFPIESSYMPE 601
Cdd:COG0514 288 -IAfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAI-------------QRFFIEQSPPDE 353
|
170
....*....|
gi 225433316 602 VVKRLSLARQ 611
Cdd:COG0514 354 ERKRVERAKL 363
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
131-674 |
1.29e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 80.84 E-value: 1.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 131 NEESATVSNDKDDVEGDSVDEAEFYEWNELRLHPLLMKSIHRLGFK-QPTPIQKACI----PAAAHQGKDVVGASETGSG 205
Cdd:COG1061 33 NLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSfELRPYQQEALeallAALERGGGRGLVVAPTGTG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 206 KTLaLGLPILQRLLEERekaaeplaenseekyaeggilRALIITPTRELALQVTDHLKEVAKGtnvrvvPIVGGMSTEKQ 285
Cdd:COG1061 113 KTV-LALALAAELLRGK---------------------RVLVLVPRRELLEQWAEELRRFLGD------PLAGGGKKDSD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 286 ERllkarpeIVVGTPGRLwelmsRGEDHLVELHSL-SFFVLDEAdrmvenghfHEL-----QSIIDILPKT-----SGSM 354
Cdd:COG1061 165 AP-------ITVATYQSL-----ARRAHLDELGDRfGLVIIDEA---------HHAgapsyRRILEAFPAAyrlglTATP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 355 ESLSQNTENCFTVSNIqrkkrqtfVFSATIalsadfrkklkrgalrsKQLMNDGLnsietLSERAGMRPNAAIVDLTNAS 434
Cdd:COG1061 224 FRSDGREILLFLFDGI--------VYEYSL-----------------KEAIEDGY-----LAPPEYYGIRVDLTDERAEY 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 435 IMANKLEESFIECREEDKDAYLYYILSVHGQG-RTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRG 513
Cdd:COG1061 274 DALSERLREALAADAERKDKILRELLREHPDDrKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRD 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 514 NEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTARASADG--CSIALISPNDRSKFANLCKSFSKESFQR 591
Cdd:COG1061 354 GELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKedALVYDFVGNDVPVLEELAKDLRDLAGYR 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 592 FPIESSYMPEVVKRLSLARQIDKISRKDSQEKAKKSWFEQNAEALELIVDESDSEEEKVKIHKQKKASSMHLNKLQQELN 671
Cdd:COG1061 434 VEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALELLELAKAEGKAEEEEEEKE 513
|
...
gi 225433316 672 MLL 674
Cdd:COG1061 514 LLL 516
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
151-328 |
8.05e-15 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 78.72 E-value: 8.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 151 EAEFYEWNElRLHPLLMKSIHRLGFKQPTPIQKACIpAAAHQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaepla 230
Cdd:COG1205 31 EARYAPWPD-WLPPELRAALKKRGIERLYSHQAEAI-EAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPGA------ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 231 enseekyaeggilRALIITPTRELAlqvTDHLKEVAK-----GTNVRVVPIVGgmSTEKQER-LLKARPEIVVGTPGRL- 303
Cdd:COG1205 103 -------------TALYLYPTKALA---RDQLRRLRElaealGLGVRVATYDG--DTPPEERrWIREHPDIVLTNPDMLh 164
|
170 180
....*....|....*....|....*..
gi 225433316 304 WELMSRGED--HLVElhSLSFFVLDEA 328
Cdd:COG1205 165 YGLLPHHTRwaRFFR--NLRYVVIDEA 189
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
188-328 |
3.52e-13 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 68.38 E-value: 3.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 188 AAAHQGKDVVGASETGSGKTLALGLPILQRLLEEREKaaeplaenseekyaeggilRALIITPTRELAlqvTDHLKEVAK 267
Cdd:cd17923 10 EAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGS-------------------RALYLYPTKALA---QDQLRSLRE 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225433316 268 -----GTNVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLWELMSRGEDHLVE-LHSLSFFVLDEA 328
Cdd:cd17923 68 lleqlGLGIRVATYDGDTPREERRAIIRNPPRILLTNPDMLHYALLPHHDRWARfLRNLRYVVLDEA 134
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
449-563 |
4.74e-13 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 66.85 E-value: 4.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 449 EEDKDAYLYYILSVHGQGRTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATdVA-AR 527
Cdd:cd18794 14 KDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVAT-VAfGM 92
|
90 100 110
....*....|....*....|....*....|....*.
gi 225433316 528 GLDIPGVRTVVHYQLPHSAEVYVHRSGRTARasaDG 563
Cdd:cd18794 93 GIDKPDVRFVIHYSLPKSMESYYQESGRAGR---DG 125
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
193-340 |
2.31e-12 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 65.68 E-value: 2.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 193 GKDVVGASETGSGKTLALGLPILQRLLEEREKAaeplaenseekyaeggiLRALIITPTRELALQVTDHLKEVAKGTN-- 270
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKG-----------------VQVLYISPLKALINDQERRLEEPLDEIDle 63
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225433316 271 VRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLwELM--SRGEDHLveLHSLSFFVLDEadrmvenghFHEL 340
Cdd:cd17922 64 IPVAVRHGDTSQSEKAKQLKNPPGILITTPESL-ELLlvNKKLREL--FAGLRYVVVDE---------IHAL 123
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
179-328 |
7.68e-12 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 64.59 E-value: 7.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 179 TPIQKACIPAAAHQGKDVVGASETGSGKTLALGLPILQRLLEerekaaeplaenseekyaEGGilRALIITPTRELALQV 258
Cdd:cd17921 3 NPIQREALRALYLSGDSVLVSAPTSSGKTLIAELAILRALAT------------------SGG--KAVYIAPTRALVNQK 62
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225433316 259 TDHLKEVAKGTNVRVVPIVGGMSTEKQErllKARPEIVVGTPGRlWELMSR-GEDHLVELHSLsfFVLDEA 328
Cdd:cd17921 63 EADLRERFGPLGKNVGLLTGDPSVNKLL---LAEADILVATPEK-LDLLLRnGGERLIQDVRL--VVVDEA 127
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
459-651 |
7.80e-11 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 65.52 E-value: 7.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 459 ILSVHGQGRTIVFCTSIAALRHTSSLLRILGINVWTLHAQ--------MQQRARLKAIDRFRGNEHGILVATDVAARGLD 530
Cdd:COG1111 347 QLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQaskegdkgLTQKEQIEILERFRAGEFNVLVATSVAEEGLD 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 531 IPGVRTVVHYQLPHSAEVYVHRSGRTARaSADGCSIALISPNDRSkfanlcKSFSKESFQRfpiESSyMPEVVKRLS-LA 609
Cdd:COG1111 427 IPEVDLVIFYEPVPSEIRSIQRKGRTGR-KREGRVVVLIAKGTRD------EAYYWSSRRK---EKK-MKSILKKLKkLL 495
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 225433316 610 RQIDKISRKDSQEKAKKSWFEQNAEALELIVDESDSEEEKVK 651
Cdd:COG1111 496 DKQEKEKLKESAQATLDEFESIKELAEDEINEKDLDEIESSE 537
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
175-300 |
3.87e-10 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 63.58 E-value: 3.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 175 FKQPTPIQKACIPAAaHQGKDVVGASETGSGKTLALGLPILQRLLEEREkaaeplaensEEKYAEGgiLRALIITPTREL 254
Cdd:COG1201 22 FGAPTPPQREAWPAI-AAGESTLLIAPTGSGKTLAAFLPALDELARRPR----------PGELPDG--LRVLYISPLKAL 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 225433316 255 A------LQVTdhLKEVAKGTNVRVVPIVGGM------STEKQeRLLKARPEIVVGTP 300
Cdd:COG1201 89 AndiernLRAP--LEEIGEAAGLPLPEIRVGVrtgdtpASERQ-RQRRRPPHILITTP 143
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
166-328 |
1.28e-09 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 61.45 E-value: 1.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 166 LMKSIHRLGFKQPTPIQKACIPAAAHQGKDVVGASETGSGKTLALGLPILQRLLeerekaaeplaenseekyaEGGilRA 245
Cdd:COG1204 11 VIEFLKERGIEELYPPQAEALEAGLLEGKNLVVSAPTASGKTLIAELAILKALL-------------------NGG--KA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 246 LIITPTRELALQVTDHLKEVAKGTNVRVvpivgGMST---EKQERLLkARPEIVVGTPGRLWELMSRGEDhlvELHSLSF 322
Cdd:COG1204 70 LYIVPLRALASEKYREFKRDFEELGIKV-----GVSTgdyDSDDEWL-GRYDILVATPEKLDSLLRNGPS---WLRDVDL 140
|
....*.
gi 225433316 323 FVLDEA 328
Cdd:COG1204 141 VVVDEA 146
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
439-559 |
1.41e-09 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 57.22 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 439 KLEESFIECREEDKDAylyyilsvhgqgRTIVFCTSIAALRHTSSLLRILGI--NVWTLH-------------AQMQQRA 503
Cdd:cd18802 11 KLIEILREYFPKTPDF------------RGIIFVERRATAVVLSRLLKEHPStlAFIRCGfligrgnssqrkrSLMTQRK 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 225433316 504 RLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRtARA 559
Cdd:cd18802 79 QKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
459-652 |
2.06e-09 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 61.04 E-value: 2.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 459 ILSVHGQGRTIVFCTSiaalRHTSS----LLRILGINVWTLHAQ--------MQQRARLKAIDRFRGNEHGILVATDVAA 526
Cdd:PRK13766 359 QLGKNPDSRIIVFTQY----RDTAEkivdLLEKEGIKAVRFVGQaskdgdkgMSQKEQIEILDKFRAGEFNVLVSTSVAE 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 527 RGLDIPGVRTVVHYQLPHSAEVYVHRSGRTARASAdGCSIALISPNDRSKfANLCKSFSKE-SFQRFPIESSYMPEVVKR 605
Cdd:PRK13766 435 EGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGRQEE-GRVVVLIAKGTRDE-AYYWSSRRKEkKMKEELKNLKGILNKKLQ 512
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 225433316 606 LSLARQIDKISRKDSQE------KAKKSWFEQNAEALELIVDESDSEEEKVKI 652
Cdd:PRK13766 513 ELDEEQKGEEEEKDEQLslddfvKSKGKEEEEEEEKEEKDKETEEDEPEGPKI 565
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
518-566 |
2.16e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.55 E-value: 2.16e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 225433316 518 ILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTARASADGCSI 566
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEV 73
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
458-563 |
3.65e-08 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 53.41 E-value: 3.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 458 YILSVHGQG-RTIVFCTSIAALRHTSSLLRILGINvwtlhAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIP---- 532
Cdd:cd18789 41 ELLKRHEQGdKIIVFTDNVEALYRYAKRLLKPFIT-----GETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLPeanv 115
|
90 100 110
....*....|....*....|....*....|.
gi 225433316 533 GVRTVVHYQlphSAEVYVHRSGRTARASADG 563
Cdd:cd18789 116 AIQISGHGG---SRRQEAQRLGRILRPKKGG 143
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
499-558 |
1.01e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 51.59 E-value: 1.01e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 499 MQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTAR 558
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
462-563 |
1.63e-07 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 54.72 E-value: 1.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 462 VHGQ-GRT-IVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVH 539
Cdd:PRK11057 231 VQEQrGKSgIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVH 310
|
90 100
....*....|....*....|....
gi 225433316 540 YQLPHSAEVYVHRSGRTARasaDG 563
Cdd:PRK11057 311 FDIPRNIESYYQETGRAGR---DG 331
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
467-543 |
3.72e-07 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 49.78 E-value: 3.72e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225433316 467 RTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFR--GNEHGILVATDVAARGLDIPGVRTVVHYQLP 543
Cdd:cd18793 29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNedPDIRVFLLSTKAGGVGLNLTAANRVILYDPW 107
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
181-327 |
9.73e-07 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 50.05 E-value: 9.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 181 IQKACIPAAAHQGKDVVGASETGSGKTLALGLPILqRLLEEREKAAEplaenseekyaegGILRALIITPTRELALQVTD 260
Cdd:cd18023 5 IQSEVFPDLLYSDKNFVVSAPTGSGKTVLFELAIL-RLLKERNPLPW-------------GNRKVVYIAPIKALCSEKYD 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225433316 261 HLKEVAKGTNVRVVPIVGGMSTEKQERLLKArpEIVVGTPGRlWELMSR-GEDHLVELHSLSFFVLDE 327
Cdd:cd18023 71 DWKEKFGPLGLSCAELTGDTEMDDTFEIQDA--DIILTTPEK-WDSMTRrWRDNGNLVQLVALVLIDE 135
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
448-533 |
2.46e-06 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 51.08 E-value: 2.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 448 REEDKDAYLYYILSVHG--QGRTIVFCTSIAALRHTSSLLR-ILGINVWtlhaqMQQRA-RLKAIDRFRGNEHGILVATD 523
Cdd:COG1199 441 RDGYLEAIAEAIAELLEasGGNTLVLFTSYRALEQVAELLReRLDIPVL-----VQGDGsREALLERFREGGNSVLVGTG 515
|
90
....*....|
gi 225433316 524 VAARGLDIPG 533
Cdd:COG1199 516 SFWEGVDLPG 525
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
175-300 |
1.15e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 49.11 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 175 FKQPTPIQKACIPAAaHQGKDVVGASETGSGKTLALGLPILQRLLEerekaaepLAENSEekyAEGGILrALIITPTREL 254
Cdd:PRK13767 30 FGTFTPPQRYAIPLI-HEGKNVLISSPTGSGKTLAAFLAIIDELFR--------LGREGE---LEDKVY-CLYVSPLRAL 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 225433316 255 A-------LQVTDHLKEVAKGTNVRVVPIVGGMST------EKQeRLLKARPEIVVGTP 300
Cdd:PRK13767 97 NndihrnlEEPLTEIREIAKERGEELPEIRVAIRTgdtssyEKQ-KMLKKPPHILITTP 154
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
467-543 |
1.73e-05 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 48.30 E-value: 1.73e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225433316 467 RTIVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHG--ILVATDVAARGLDIPGVRTVVHYQLP 543
Cdd:COG0553 551 KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEApvFLISLKAGGEGLNLTAADHVIHYDLW 629
|
|
| secA |
PRK12898 |
preprotein translocase subunit SecA; Reviewed |
462-574 |
2.85e-05 |
|
preprotein translocase subunit SecA; Reviewed
Pssm-ID: 237253 [Multi-domain] Cd Length: 656 Bit Score: 47.70 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 462 VHGQGRTIVFCT-SIAALRHTSSLLRILGINVWTLHAQmqQRARLKAIDRFRGNEHGILVATDVAARGLDI---PGVRT- 536
Cdd:PRK12898 469 LHAQGRPVLVGTrSVAASERLSALLREAGLPHQVLNAK--QDAEEAAIVARAGQRGRITVATNMAGRGTDIklePGVAAr 546
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 225433316 537 ----VVHYQLPHSAEVYVHRSGRTARASADGCSIALISPNDR 574
Cdd:PRK12898 547 gglhVILTERHDSARIDRQLAGRCGRQGDPGSYEAILSLEDD 588
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
202-328 |
4.17e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 45.34 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 202 TGSGKTLalglpILQRLLeeREKAAEPLAENSEEKyaeggilRALIITPTRELALQVTdhlKEVAKGTNVRVVPIVGGMS 281
Cdd:cd18034 25 TGSGKTL-----IAVMLI--KEMGELNRKEKNPKK-------RAVFLVPTVPLVAQQA---EAIRSHTDLKVGEYSGEMG 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 225433316 282 TEKQERLLK----ARPEIVVGTPGRLWELMSRGEdhlVELHSLSFFVLDEA 328
Cdd:cd18034 88 VDKWTKERWkeelEKYDVLVMTAQILLDALRHGF---LSLSDINLLIFDEC 135
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
467-558 |
4.32e-05 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 43.32 E-value: 4.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 467 RTIVFCTSIAALRHTSSLLRILGINVWTLHAQ--MQQRARLKAIDRFRGNEHG-ILVATDVAARGLDIPGVRTVVHYQLP 543
Cdd:cd18799 8 KTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDysDRERGDEALILLFFGELKPpILVTVDLLTTGVDIPEVDNVVFLRPT 87
|
90
....*....|....*
gi 225433316 544 HSAEVYVHRSGRTAR 558
Cdd:cd18799 88 ESRTLFLQMLGRGLR 102
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
202-327 |
1.06e-04 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 46.07 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 202 TGSGKTLALGLPILQRLLEERekaaeplAENSEEKYaEGGILRALIITPTRELALQVTDHLKEVAKG------------T 269
Cdd:PRK09751 5 TGSGKTLAAFLYALDRLFREG-------GEDTREAH-KRKTSRILYISPIKALGTDVQRNLQIPLKGiaderrrrgeteV 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 225433316 270 NVRVVPIVGGMSTEKQERLLKARPEIVVGTPGRLW-ELMSRGEDHLVELHSLsffVLDE 327
Cdd:PRK09751 77 NLRVGIRTGDTPAQERSKLTRNPPDILITTPESLYlMLTSRARETLRGVETV---IIDE 132
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
175-328 |
1.48e-04 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 43.40 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 175 FKQPTPIQKACIPAAAHQGKDVVGASETGSGKTLALGLPILqRLLEEREKAaeplaenseekyaeggilRALIITPTREL 254
Cdd:cd18021 1 FKFFNPIQTQVFNSLYNTDDNVFVGAPTGSGKTVCAELALL-RHWRQNPKG------------------RAVYIAPMQEL 61
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225433316 255 A-LQVTDHLKEVAKGTNVRVVPIVGGMSTEKqeRLLkARPEIVVGTPGRlWELMSRGEDHLVELHSLSFFVLDEA 328
Cdd:cd18021 62 VdARYKDWRAKFGPLLGKKVVKLTGETSTDL--KLL-AKSDVILATPEQ-WDVLSRRWKQRKNVQSVELFIADEL 132
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
158-239 |
7.74e-04 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 42.88 E-value: 7.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 158 NELRLHPLLMKSIHRLGFKQPTPIQKACIPAAAHQGKDVVGASETGSGKTLALGLPILQRLLEEREKAAE--PLAENSEE 235
Cdd:PRK00254 4 DELRVDERIKRVLKERGIEELYPPQAEALKSGVLEGKNLVLAIPTASGKTLVAEIVMVNKLLREGGKAVYlvPLKALAEE 83
|
....
gi 225433316 236 KYAE 239
Cdd:PRK00254 84 KYRE 87
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
469-558 |
2.99e-03 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 41.42 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 469 IVFCTSIAALRHTSSLLRILGINVWTLHAQMQQRARLKAIDRFRGNEHGILVATDVAARGLDIPGVRTVVHYQLPHSAEV 548
Cdd:PLN03137 684 IIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEG 763
|
90
....*....|
gi 225433316 549 YVHRSGRTAR 558
Cdd:PLN03137 764 YHQECGRAGR 773
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
244-329 |
3.15e-03 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 39.62 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 244 RALIITPTRELALQVTDHLKEVAKGTNVRVVPIV--GGMSTEKQERLLKARPE----IVVGTPGRLwelmSRGEDHLVEl 317
Cdd:cd17924 62 RSYLIFPTKSLVKQAYERLSKYAEKAGVEVKILVyhSRLKKKEKEELLEKIEKgdfdILVTTNQFL----SKNFDLLSN- 136
|
90
....*....|..
gi 225433316 318 HSLSFFVLDEAD 329
Cdd:cd17924 137 KKFDFVFVDDVD 148
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
454-558 |
3.37e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 38.78 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 454 AYLYYILSVHGQgRTIVFCTSIAA----LRHTSSLLRILGINVWTLhaqMQQRARLKAIDR-------FRGNEHGIlVAT 522
Cdd:cd18797 25 ARLFADLVRAGV-KTIVFCRSRKLaellLRYLKARLVEEGPLASKV---ASYRAGYLAEDRreieaelFNGELLGV-VAT 99
|
90 100 110
....*....|....*....|....*....|....*.
gi 225433316 523 DVAARGLDIPGVRTVVHYQLPHSAEVYVHRSGRTAR 558
Cdd:cd18797 100 NALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGR 135
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
181-334 |
9.41e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 37.88 E-value: 9.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225433316 181 IQKACIPAAAHQGKDVVGASeTGSGKTLALGLPILQRLleerekaaeplaenseEKYaeGGilRALIITPTRELALQVTD 260
Cdd:cd18035 5 LYQVLIAAVALNGNTLIVLP-TGLGKTIIAILVAADRL----------------TKK--GG--KVLILAPSRPLVEQHAE 63
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225433316 261 HLKEVAKGTNvRVVPIVGGMSTEKQERLLKaRPEIVVGTPGRLWELMSRGEdhlVELHSLSFFVLDEADRMVEN 334
Cdd:cd18035 64 NLKRVLNIPD-KITSLTGEVKPEERAERWD-ASKIIVATPQVIENDLLAGR---ITLDDVSLLIFDEAHHAVGN 132
|
|
| |
