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Conserved domains on  [gi|198436174|ref|XP_002129128|]
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putative protocadherin beta-18 [Ciona intestinalis]

Protein Classification

protocadherin( domain architecture ID 13228088)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 265-365 8.39e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 8.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 265 YTLNLRENLPRGEIITSVQAHDEDSGTFGQVRYFVpASGNSQtarKLIRVDPITGDVMLKQPLDREKHNNIRFVIGARDM 344
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 198436174 345 GKEAKTGKTMLEIRVADVNDN 365
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-612 4.82e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 502 LSLREDALKGTHLVKMSANDADAvylpamrmsktkernienSTNGDITYELHGG--KGCFSINPHSGVITLVGAPDYEAR 579
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDS------------------GENGEVTYSIVSGneDGLFSIDPSTGEITTAKPLDREEQ 65

                         90       100       110
                 ....*....|....*....|....*....|...
gi 198436174 580 KLWKLIVTAKDGGNPSLSTNSSLDVNVLDVNDN 612
Cdd:cd11304   66 SSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 382-491 5.47e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 382 TAYVPESARIGTYVASISANDVDIGINGDVTietsvegyaagrpadFSPNADSLQSYFS-RSDGGILSTGFPLDREDIPM 460
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVT---------------YSIVSGNEDGLFSiDPSTGEITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 198436174 461 FVVRISACDHGMPARCSEQNLTIIVLDENDH 491
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 153-256 7.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 153 IITVNVSEAVPMGTKISLDKylATDDDVGRNKDIVYVATSSDN---FGIHQykdETGaphlELVVADELDHETAATEDLI 229
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVS--ATDPDSGENGEVTYSIVSGNEdglFSIDP---STG----EITTAKPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*..
gi 198436174 230 ITASDRGTPTLKNHVTLRIGILDANDN 256
Cdd:cd11304   72 VTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 635-719 4.43e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 635 VIIKINAIDYDQGAHSDVWYSLVSENGEKPpkdFILNQLSGDFRLNfsNPKMSEMLGLHAIVVKAQDLGSPPLKSEIIFY 714
Cdd:cd11304   15 VVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGGPPLSSTATVT 89


                 ....*
gi 198436174 715 VEVTD 719
Cdd:cd11304   90 ITVLD 94
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 33-118 4.02e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 42.90  E-value: 4.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   33 TIRIQFLEEQPEATVVYNLKEDLLASQREgvyfkmLSqymTSGVDI-TDDVTEWVQLDENSGIVTVNTPVDRETMCDAdd 111
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGE------LA---ARGARVvSKGNKQYFQLNPETGDLLLNEKLDREELCGS-- 69


                  ....*..
gi 198436174  112 TQPCVIH 118
Cdd:pfam08266  70 TEPCVLH 76
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 265-365 8.39e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 8.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 265 YTLNLRENLPRGEIITSVQAHDEDSGTFGQVRYFVpASGNSQtarKLIRVDPITGDVMLKQPLDREKHNNIRFVIGARDM 344
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 198436174 345 GKEAKTGKTMLEIRVADVNDN 365
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-612 4.82e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 502 LSLREDALKGTHLVKMSANDADAvylpamrmsktkernienSTNGDITYELHGG--KGCFSINPHSGVITLVGAPDYEAR 579
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDS------------------GENGEVTYSIVSGneDGLFSIDPSTGEITTAKPLDREEQ 65

                         90       100       110
                 ....*....|....*....|....*....|...
gi 198436174 580 KLWKLIVTAKDGGNPSLSTNSSLDVNVLDVNDN 612
Cdd:cd11304   66 SSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 544-614 7.77e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 7.77e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198436174   544 TNGDITYELHGG--KGCFSINPHSGVITLVGAPDYEARKLWKLIVTAKDGGNPSLSTNSSLDVNVLDVNDNSP 614
Cdd:smart00112   9 ENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 382-491 5.47e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 382 TAYVPESARIGTYVASISANDVDIGINGDVTietsvegyaagrpadFSPNADSLQSYFS-RSDGGILSTGFPLDREDIPM 460
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVT---------------YSIVSGNEDGLFSiDPSTGEITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 198436174 461 FVVRISACDHGMPARCSEQNLTIIVLDENDH 491
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-367 5.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 5.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   283 QAHDEDSGTFGQVRYfvpaSGNSQTARKLIRVDPITGDVMLKQPLDREKHNNIRFVIGARDMGKEAKTGKTMLEIRVADV 362
Cdd:smart00112   1 SATDADSGENGKVTY----SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 198436174   363 NDNFP 367
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 153-256 7.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 153 IITVNVSEAVPMGTKISLDKylATDDDVGRNKDIVYVATSSDN---FGIHQykdETGaphlELVVADELDHETAATEDLI 229
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVS--ATDPDSGENGEVTYSIVSGNEdglFSIDP---STG----EITTAKPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*..
gi 198436174 230 ITASDRGTPTLKNHVTLRIGILDANDN 256
Cdd:cd11304   72 VTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
265-359 1.64e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  265 YTLNLRENLPRGEIITSVQAHDEDSGTFGQVRYFVpASGNSqtaRKLIRVDPITGDVMLKQPLDREKHNNIRFVIGARDM 344
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGP---GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 198436174  345 GKEAKTGKTMLEIRV 359
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-258 6.58e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 6.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   175 ATDDDVGRNKDIVYVATSSDNFGIHQYKDETGaphlELVVADELDHETAATEDLIITASDRGTPTLKNHVTLRIGILDAN 254
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 198436174   255 DNAP 258
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 399-493 8.48e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 8.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   399 SANDVDIGINGDVTietsvegyaagrpadFSPNADSLQSYFS-RSDGGILSTGFPLDREDIPMFVVRISACDHGMPARCS 477
Cdd:smart00112   1 SATDADSGENGKVT---------------YSILSGNDDGLFSiDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSS 65

                           90
                   ....*....|....*.
gi 198436174   478 EQNLTIIVLDENDHAP 493
Cdd:smart00112  66 TATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
503-607 1.68e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  503 SLREDALKGTHLVKMSANDADAvylpamrmsktkernienSTNGDITYEL--HGGKGCFSINPHSGVITLVGAPDYEARK 580
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDL------------------GPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIG 65

                          90       100
                  ....*....|....*....|....*..
gi 198436174  581 LWKLIVTAKDGGNPSLSTNSSLDVNVL 607
Cdd:pfam00028  66 EYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 635-719 4.43e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 635 VIIKINAIDYDQGAHSDVWYSLVSENGEKPpkdFILNQLSGDFRLNfsNPKMSEMLGLHAIVVKAQDLGSPPLKSEIIFY 714
Cdd:cd11304   15 VVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGGPPLSSTATVT 89


                 ....*
gi 198436174 715 VEVTD 719
Cdd:cd11304   90 ITVLD 94
Cadherin pfam00028
Cadherin domain;
382-486 1.98e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  382 TAYVPESARIGTYVASISANDVDIGINGDVT---IETSVEGyaagrpaDFSPNADSlqsyfsrsdgGILSTGFPLDREDI 458
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFysiLGGGPGG-------NFRIDPDT----------GDISTTKPLDRESI 64

                          90       100
                  ....*....|....*....|....*...
gi 198436174  459 PMFVVRISACDHGMPARCSEQNLTIIVL 486
Cdd:pfam00028  65 GEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
154-251 3.25e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  154 ITVNVSEAVPMGTKISLdkYLATDDDVGRNKDIVYVATS---SDNFGIHQykdETGaphlELVVADELDHETAATEDLII 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPNGRIFYSILGggpGGNFRIDP---DTG----DISTTKPLDRESIGEYELTV 71

                          90       100
                  ....*....|....*....|.
gi 198436174  231 TASDRGTPTLKNHVTLRIGIL 251
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
636-718 3.45e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  636 IIKINAIDYDQGAHSDVWYSLVSENgekPPKDFILNQLSGDF----RLNFsnpkmsEMLGLHAIVVKAQDLGSPPLKSEI 711
Cdd:pfam00028  15 VLTVTATDPDLGPNGRIFYSILGGG---PGGNFRIDPDTGDIsttkPLDR------ESIGEYELTVEATDSGGPPLSSTA 85


                  ....*..
gi 198436174  712 IFYVEVT 718
Cdd:pfam00028  86 TVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 640-719 1.13e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   640 NAIDYDQGAHSDVWYSLVSENGEKPpkdFILNQLSGDFR----LNFsnpkmsEMLGLHAIVVKAQDLGSPPLKSEIIFYV 715
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL---FSIDPETGEITttkpLDR------EEQPEYTLTVEATDGGGPPLSSTATVTI 71


                   ....
gi 198436174   716 EVTD 719
Cdd:smart00112  72 TVLD 75
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 33-118 4.02e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 42.90  E-value: 4.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   33 TIRIQFLEEQPEATVVYNLKEDLLASQREgvyfkmLSqymTSGVDI-TDDVTEWVQLDENSGIVTVNTPVDRETMCDAdd 111
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGE------LA---ARGARVvSKGNKQYFQLNPETGDLLLNEKLDREELCGS-- 69


                  ....*..
gi 198436174  112 TQPCVIH 118
Cdd:pfam08266  70 TEPCVLH 76
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 265-365 8.39e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 8.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 265 YTLNLRENLPRGEIITSVQAHDEDSGTFGQVRYFVpASGNSQtarKLIRVDPITGDVMLKQPLDREKHNNIRFVIGARDM 344
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 198436174 345 GKEAKTGKTMLEIRVADVNDN 365
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-612 4.82e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 502 LSLREDALKGTHLVKMSANDADAvylpamrmsktkernienSTNGDITYELHGG--KGCFSINPHSGVITLVGAPDYEAR 579
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDS------------------GENGEVTYSIVSGneDGLFSIDPSTGEITTAKPLDREEQ 65

                         90       100       110
                 ....*....|....*....|....*....|...
gi 198436174 580 KLWKLIVTAKDGGNPSLSTNSSLDVNVLDVNDN 612
Cdd:cd11304   66 SSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 544-614 7.77e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 7.77e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198436174   544 TNGDITYELHGG--KGCFSINPHSGVITLVGAPDYEARKLWKLIVTAKDGGNPSLSTNSSLDVNVLDVNDNSP 614
Cdd:smart00112   9 ENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 382-491 5.47e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 382 TAYVPESARIGTYVASISANDVDIGINGDVTietsvegyaagrpadFSPNADSLQSYFS-RSDGGILSTGFPLDREDIPM 460
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVT---------------YSIVSGNEDGLFSiDPSTGEITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 198436174 461 FVVRISACDHGMPARCSEQNLTIIVLDENDH 491
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-367 5.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 5.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   283 QAHDEDSGTFGQVRYfvpaSGNSQTARKLIRVDPITGDVMLKQPLDREKHNNIRFVIGARDMGKEAKTGKTMLEIRVADV 362
Cdd:smart00112   1 SATDADSGENGKVTY----SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 198436174   363 NDNFP 367
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 153-256 7.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 153 IITVNVSEAVPMGTKISLDKylATDDDVGRNKDIVYVATSSDN---FGIHQykdETGaphlELVVADELDHETAATEDLI 229
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVS--ATDPDSGENGEVTYSIVSGNEdglFSIDP---STG----EITTAKPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*..
gi 198436174 230 ITASDRGTPTLKNHVTLRIGILDANDN 256
Cdd:cd11304   72 VTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
265-359 1.64e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  265 YTLNLRENLPRGEIITSVQAHDEDSGTFGQVRYFVpASGNSqtaRKLIRVDPITGDVMLKQPLDREKHNNIRFVIGARDM 344
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGP---GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 198436174  345 GKEAKTGKTMLEIRV 359
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-258 6.58e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 6.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   175 ATDDDVGRNKDIVYVATSSDNFGIHQYKDETGaphlELVVADELDHETAATEDLIITASDRGTPTLKNHVTLRIGILDAN 254
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 198436174   255 DNAP 258
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 399-493 8.48e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 8.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   399 SANDVDIGINGDVTietsvegyaagrpadFSPNADSLQSYFS-RSDGGILSTGFPLDREDIPMFVVRISACDHGMPARCS 477
Cdd:smart00112   1 SATDADSGENGKVT---------------YSILSGNDDGLFSiDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSS 65

                           90
                   ....*....|....*.
gi 198436174   478 EQNLTIIVLDENDHAP 493
Cdd:smart00112  66 TATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
503-607 1.68e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  503 SLREDALKGTHLVKMSANDADAvylpamrmsktkernienSTNGDITYEL--HGGKGCFSINPHSGVITLVGAPDYEARK 580
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDL------------------GPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIG 65

                          90       100
                  ....*....|....*....|....*..
gi 198436174  581 LWKLIVTAKDGGNPSLSTNSSLDVNVL 607
Cdd:pfam00028  66 EYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 635-719 4.43e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174 635 VIIKINAIDYDQGAHSDVWYSLVSENGEKPpkdFILNQLSGDFRLNfsNPKMSEMLGLHAIVVKAQDLGSPPLKSEIIFY 714
Cdd:cd11304   15 VVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGGPPLSSTATVT 89


                 ....*
gi 198436174 715 VEVTD 719
Cdd:cd11304   90 ITVLD 94
Cadherin pfam00028
Cadherin domain;
382-486 1.98e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  382 TAYVPESARIGTYVASISANDVDIGINGDVT---IETSVEGyaagrpaDFSPNADSlqsyfsrsdgGILSTGFPLDREDI 458
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFysiLGGGPGG-------NFRIDPDT----------GDISTTKPLDRESI 64

                          90       100
                  ....*....|....*....|....*...
gi 198436174  459 PMFVVRISACDHGMPARCSEQNLTIIVL 486
Cdd:pfam00028  65 GEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
154-251 3.25e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  154 ITVNVSEAVPMGTKISLdkYLATDDDVGRNKDIVYVATS---SDNFGIHQykdETGaphlELVVADELDHETAATEDLII 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPNGRIFYSILGggpGGNFRIDP---DTG----DISTTKPLDRESIGEYELTV 71

                          90       100
                  ....*....|....*....|.
gi 198436174  231 TASDRGTPTLKNHVTLRIGIL 251
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
636-718 3.45e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174  636 IIKINAIDYDQGAHSDVWYSLVSENgekPPKDFILNQLSGDF----RLNFsnpkmsEMLGLHAIVVKAQDLGSPPLKSEI 711
Cdd:pfam00028  15 VLTVTATDPDLGPNGRIFYSILGGG---PGGNFRIDPDTGDIsttkPLDR------ESIGEYELTVEATDSGGPPLSSTA 85


                  ....*..
gi 198436174  712 IFYVEVT 718
Cdd:pfam00028  86 TVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 640-719 1.13e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   640 NAIDYDQGAHSDVWYSLVSENGEKPpkdFILNQLSGDFR----LNFsnpkmsEMLGLHAIVVKAQDLGSPPLKSEIIFYV 715
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL---FSIDPETGEITttkpLDR------EEQPEYTLTVEATDGGGPPLSSTATVTI 71


                   ....
gi 198436174   716 EVTD 719
Cdd:smart00112  72 TVLD 75
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 33-118 4.02e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 42.90  E-value: 4.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198436174   33 TIRIQFLEEQPEATVVYNLKEDLLASQREgvyfkmLSqymTSGVDI-TDDVTEWVQLDENSGIVTVNTPVDRETMCDAdd 111
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGE------LA---ARGARVvSKGNKQYFQLNPETGDLLLNEKLDREELCGS-- 69


                  ....*..
gi 198436174  112 TQPCVIH 118
Cdd:pfam08266  70 TEPCVLH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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