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Conserved domains on  [gi|196002809|ref|XP_002111272|]
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uncharacterized protein TRIADDRAFT_22960 [Trichoplax adhaerens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549439)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens tRNA N(3)-methylcytidine methyltransferase METTL6

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-189 1.38e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 62.39  E-value: 1.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809   88 LEVGCGVGNAVFPLIEEGCQLYIYACDFSPRAIDFVKsNRLYDEAKCHAFVCDITCDDLTLSIPaATINIATLIFVLSAI 167
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAAR-ERLAALGLLNAVRVELFQLDLGELDP-GSFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|..
gi 196002809  168 tpQKMSAAIANIGKVMATGGTL 189
Cdd:pfam08242  79 --ADPRAVLRNIRRLLKPGGVL 98
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-189 1.38e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 62.39  E-value: 1.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809   88 LEVGCGVGNAVFPLIEEGCQLYIYACDFSPRAIDFVKsNRLYDEAKCHAFVCDITCDDLTLSIPaATINIATLIFVLSAI 167
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAAR-ERLAALGLLNAVRVELFQLDLGELDP-GSFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|..
gi 196002809  168 tpQKMSAAIANIGKVMATGGTL 189
Cdd:pfam08242  79 --ADPRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 88-191 9.98e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.85  E-value: 9.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  88 LEVGCGVGNAVFPLIEEGCQLYIyACDFSPRAIDFVKsnRLYDEAKCHAfvCDITCDDLT--LSIPAATINIATLIFVLS 165
Cdd:COG0500   31 LDLGCGTGRNLLALAARFGGRVI-GIDLSPEAIALAR--ARAAKAGLGN--VEFLVADLAelDPLPAESFDLVVAFGVLH 105

                         90       100
                 ....*....|....*....|....*.
gi 196002809 166 AITPQKMSAAIANIGKVMATGGTLLF 191
Cdd:COG0500  106 HLPPEEREALLRELARALKPGGVLLL 131
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 88-191 3.49e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  88 LEVGCGVGNAVFPLIEEGCQlYIYACDFSPRAIDFVKSNRLYDEA-KCHAFVCDItcddltLSIPAATINIATLIFVLSA 166
Cdd:cd02440    3 LDLGCGTGALALALASGPGA-RVTGVDISPVALELARKAAAALLAdNVEVLKGDA------EELPPEADESFDVIISDPP 75

                         90       100
                 ....*....|....*....|....*..
gi 196002809 167 ITPQKMS--AAIANIGKVMATGGTLLF 191
Cdd:cd02440   76 LHHLVEDlaRFLEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-189 1.38e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 62.39  E-value: 1.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809   88 LEVGCGVGNAVFPLIEEGCQLYIYACDFSPRAIDFVKsNRLYDEAKCHAFVCDITCDDLTLSIPaATINIATLIFVLSAI 167
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAAR-ERLAALGLLNAVRVELFQLDLGELDP-GSFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|..
gi 196002809  168 tpQKMSAAIANIGKVMATGGTL 189
Cdd:pfam08242  79 --ADPRAVLRNIRRLLKPGGVL 98
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 88-187 6.59e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.27  E-value: 6.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809   88 LEVGCGVGNAVFPLIEEGcQLYIYACDFSPRAIDFVKSNRLYDEAKCHAFVCDITcddlTLSIPAATINIATLIFVLSAI 167
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAE----DLPFPDGSFDLVVSSGVLHHL 76

                          90       100
                  ....*....|....*....|
gi 196002809  168 TPQKMSAAIANIGKVMATGG 187
Cdd:pfam13649  77 PDPDLEAALREIARVLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 88-191 9.98e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.85  E-value: 9.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  88 LEVGCGVGNAVFPLIEEGCQLYIyACDFSPRAIDFVKsnRLYDEAKCHAfvCDITCDDLT--LSIPAATINIATLIFVLS 165
Cdd:COG0500   31 LDLGCGTGRNLLALAARFGGRVI-GIDLSPEAIALAR--ARAAKAGLGN--VEFLVADLAelDPLPAESFDLVVAFGVLH 105

                         90       100
                 ....*....|....*....|....*.
gi 196002809 166 AITPQKMSAAIANIGKVMATGGTLLF 191
Cdd:COG0500  106 HLPPEEREALLRELARALKPGGVLLL 131
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 88-203 2.40e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 54.61  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  88 LEVGCGVGNAVFPLIEEGCQlyIYACDFSPRAIDFVKSNRLYDEAKCHAFVCDITcddlTLSIPAATINIATLIFVLSAI 167
Cdd:COG2226   27 LDLGCGTGRLALALAERGAR--VTGVDISPEMLELARERAAEAGLNVEFVVGDAE----DLPFPDGSFDLVISSFVLHHL 100

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 196002809 168 TPQKmsAAIANIGKVMATGGTLLFRDYGIYDHAMLR 203
Cdd:COG2226  101 PDPE--RALAEIARVLKPGGRLVVVDFSPPDLAELE 134
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 88-194 1.39e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.94  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  88 LEVGCGVGNAVFPLIEEGCQlyIYACDFSPRAIDFVKsnRLYDEAKCHAFVCDITcddlTLSIPAATINIATLIFVLSAI 167
Cdd:COG2227   29 LDVGCGTGRLALALARRGAD--VTGVDISPEALEIAR--ERAAELNVDFVQGDLE----DLPLEDGSFDLVICSEVLEHL 100

                         90       100
                 ....*....|....*....|....*..
gi 196002809 168 TPQKmsAAIANIGKVMATGGTLLFRDY 194
Cdd:COG2227  101 PDPA--ALLRELARLLKPGGLLLLSTP 125
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 88-244 1.73e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 52.82  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809   88 LEVGCGVGNAVFPLIEEGCQLYIYacDFSPRAIDFVKSNRLYDEAkchafvcditcDDLTLSIPAATINIATLIFVLSAI 167
Cdd:pfam13489  27 LDFGCGTGIFLRLLRAQGFSVTGV--DPSPIAIERALLNVRFDQF-----------DEQEAAVPAGKFDVIVAREVLEHV 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 196002809  168 tpQKMSAAIANIGKVMATGGTLLFRDYGIYDHAmlrfsrGHKIDDNFYVRQDGTMAYFFSEEATRKLFIGEGFEVVT 244
Cdd:pfam13489  94 --PDPPALLRQIAALLKPGGLLLLSTPLASDEA------DRLLLEWPYLRPRNGHISLFSARSLKRLLEEAGFEVVS 162
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-191 1.90e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 45.35  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809   88 LEVGCGVGNAVFPLIEEGCQlyIYACDFSPRAIDFVKSNrlYDEAKCHAFVCDITcddlTLSIPAATINIATLIFVLSAI 167
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREK--APREGLTFVVGDAE----DLPFPDNSFDLVLSSEVLHHV 72

                          90       100
                  ....*....|....*....|....
gi 196002809  168 TPQkmSAAIANIGKVMATGGTLLF 191
Cdd:pfam08241  73 EDP--ERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 88-191 3.49e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  88 LEVGCGVGNAVFPLIEEGCQlYIYACDFSPRAIDFVKSNRLYDEA-KCHAFVCDItcddltLSIPAATINIATLIFVLSA 166
Cdd:cd02440    3 LDLGCGTGALALALASGPGA-RVTGVDISPVALELARKAAAALLAdNVEVLKGDA------EELPPEADESFDVIISDPP 75

                         90       100
                 ....*....|....*....|....*..
gi 196002809 167 ITPQKMS--AAIANIGKVMATGGTLLF 191
Cdd:cd02440   76 LHHLVEDlaRFLEEARRLLKPGGVLVL 102
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
85-191 5.55e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.68  E-value: 5.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  85 RYMLEVGCGVGNAVFPLIEEGcqLYIYACDFSPRAIDFVKSNRLYDEakchAFVCDITcddlTLSIPAATINIATLIFVL 164
Cdd:COG4976   48 GRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAREKGVYDR----LLVADLA----DLAEPDGRFDLIVAADVL 117

                         90       100
                 ....*....|....*....|....*..
gi 196002809 165 SAITPQKmsAAIANIGKVMATGGTLLF 191
Cdd:COG4976  118 TYLGDLA--AVFAGVARALKPGGLFIF 142
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
88-191 6.74e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 35.18  E-value: 6.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809  88 LEVGCGVGNAVFPLIEEGCQLYIYACDFSPRAIDFVKSNRlydeAKCHAFVCDITcdDLTLSIPAATIniaTLIFVLSAI 167
Cdd:COG4106    6 LDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL----PNVRFVVADLR--DLDPPEPFDLV---VSNAALHWL 76

                         90       100
                 ....*....|....*....|....
gi 196002809 168 TPQKmsAAIANIGKVMATGGTLLF 191
Cdd:COG4106   77 PDHA--ALLARLAAALAPGGVLAV 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 86-194 8.73e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 35.86  E-value: 8.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002809   86 YMLEVGCGVGNAVFPLIEEGC-QLYIYACDFSPRAIDFVKSNrlydeAKCHAF------VCDITcdDLTLSIPAATINIA 158
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELGpNAEVVGIDISEEAIEKAREN-----AQKLGFdnvefeQGDIE--ELPELLEDDKFDVV 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 196002809  159 TLIFVLSAITpqKMSAAIANIGKVMATGGTLLFRDY 194
Cdd:pfam13847  79 ISNCVLNHIP--DPDKVLQEILRVLKPGGRLIISDP 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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