NCBI Conserved Domain Search

Conserved domains on [gi|189203433|ref|XP_001938052|]

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uncharacterized protein PTRG_07720 [Pyrenophora tritici-repentis Pt-1C-BFP]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085

PubMed: 26758938|26098515

SCOP: 3000310

TCDB: 2.A.1

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS super family

cl28910

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

59-508

8.27e-86

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

The actual alignment was detected with superfamily member cd17323:

Pssm-ID: 475125 [Multi-domain] Cd Length: 376 Bit Score: 270.22 E-value: 8.27e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 219 IFSGvllvlfvflfpetcrkvvgngsippqgvnrsvisciqqrklaklspdeistkpekkkIAWPNPLATFRILAekesg 298
Cdd:cd17323  161 IISG---------------------------------------------------------FCLILIFLFLPIVL----- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 299 ILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGmtitkgkqqdl 378
Cdd:cd17323  179 LLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNG----------- 247

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 379 sNFPLERVRLQILIPGHILGMFGLVMFGWTLKFRTHIVGPEIALFVMGFGVTTAFNITNGLLIDLHRDQPAAATAAVNFA 458
Cdd:cd17323  248 -GKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLV 326

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 189203433 459 RCFMSAGGTAAIIPMCHAMNPGWAFTFIAFIYVILLGVVLWVMRNGMKWR 508
Cdd:cd17323  327 RSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376

Name

Accession

Description

Interval

E-value

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

59-508

8.27e-86

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 270.22 E-value: 8.27e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 219 IFSGvllvlfvflfpetcrkvvgngsippqgvnrsvisciqqrklaklspdeistkpekkkIAWPNPLATFRILAekesg 298
Cdd:cd17323  161 IISG---------------------------------------------------------FCLILIFLFLPIVL----- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 299 ILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGmtitkgkqqdl 378
Cdd:cd17323  179 LLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNG----------- 247

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 379 sNFPLERVRLQILIPGHILGMFGLVMFGWTLKFRTHIVGPEIALFVMGFGVTTAFNITNGLLIDLHRDQPAAATAAVNFA 458
Cdd:cd17323  248 -GKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLV 326

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 189203433 459 RCFMSAGGTAAIIPMCHAMNPGWAFTFIAFIYVILLGVVLWVMRNGMKWR 508
Cdd:cd17323  327 RSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

55-447

1.00e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 1.00e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSI 134
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:COG2814   88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 215 WFLAIFSGVLLVLFVFLFPEtcrkvvgngsippqgvnrsvisciqqrklaklspdeisTKPEKKKiawPNPLATFRILAE 294
Cdd:COG2814  168 LVNAVLALLALLLLLRLLPE--------------------------------------SRPAARA---RLRGSLRELLRR 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 295 KESGILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRyaraigmtitkgk 374
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR------------- 273

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 375 qqdlsnfplervrlQILIPGHILGMFGLVMFGWTlkfrTHIVGPEIALFVMGFGVTTAFNITNGLLIDLHRDQ 447
Cdd:COG2814  274 --------------RLLLIGLLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328

MFS_1

pfam07690

Major Facilitator Superfamily;

62-443

1.45e-31

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.84 E-value: 1.45e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   62 VSISSLISPFGASMFLPAL-NVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLA 140
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  141 LQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIF 220
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  221 sgvllvlfvflfpetcrkvvgngsippqgvnrSVISCIqqrkLAKLSPDEISTKPEKKKIAWPNPLATFRILAEKESGIL 300
Cdd:pfam07690 161 --------------------------------SLLAAV----LLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  301 LMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRryaraigmtitkgkqqdlsn 380
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR-------------------- 264

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433  381 fpleRVRLQILIPGHILGMFGLVMFGWTLKFRTHIVgpeiALFVMGFGVTTAFNITNGLLIDL 443
Cdd:pfam07690 265 ----RRRLLLALLLLILAALGLLLLSLTLSSLWLLL----ALLLLGFGFGLVFPALNALVSDL 319

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

58-355

3.05e-30

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 122.11 E-value: 3.05e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   58 IIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNI 137
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  138 GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL 217
Cdd:TIGR00710  86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  218 AIFSGVLLVLFVFLFPETCRKvvgngsippqgVNRSVISCIQQRKLAKLspdeistkpeKKKIAWPNPLATfrilaekes 297
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPY-----------EARIQISTYFETFLLLL----------KSKMFWGYALIY--------- 215

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433  298 gillmynGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVV 355
Cdd:TIGR00710 216 -------GASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFI 266

emrD

PRK11652

multidrug transporter EmrD;

58-236

2.95e-17

multidrug transporter EmrD;

Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 83.80 E-value: 2.95e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  58 IIFLVSISSLispfGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNI 137
Cdd:PRK11652  13 LVLLVAVGQM----AQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 138 GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL 217
Cdd:PRK11652  89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFL 168

                        170
                 ....*....|....*....
gi 189203433 218 AIFSGVLLVLFVFLFPETC 236
Cdd:PRK11652 169 LLLGAGVTFSMARWMPETR 187

Name

Accession

Description

Interval

E-value

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

59-508

8.27e-86

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 270.22 E-value: 8.27e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 219 IFSGvllvlfvflfpetcrkvvgngsippqgvnrsvisciqqrklaklspdeistkpekkkIAWPNPLATFRILAekesg 298
Cdd:cd17323  161 IISG---------------------------------------------------------FCLILIFLFLPIVL----- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 299 ILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGmtitkgkqqdl 378
Cdd:cd17323  179 LLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNG----------- 247

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 379 sNFPLERVRLQILIPGHILGMFGLVMFGWTLKFRTHIVGPEIALFVMGFGVTTAFNITNGLLIDLHRDQPAAATAAVNFA 458
Cdd:cd17323  248 -GKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLV 326

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 189203433 459 RCFMSAGGTAAIIPMCHAMNPGWAFTFIAFIYVILLGVVLWVMRNGMKWR 508
Cdd:cd17323  327 RSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

55-447

1.00e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 1.00e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSI 134
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:COG2814   88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 215 WFLAIFSGVLLVLFVFLFPEtcrkvvgngsippqgvnrsvisciqqrklaklspdeisTKPEKKKiawPNPLATFRILAE 294
Cdd:COG2814  168 LVNAVLALLALLLLLRLLPE--------------------------------------SRPAARA---RLRGSLRELLRR 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 295 KESGILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRyaraigmtitkgk 374
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR------------- 273

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 375 qqdlsnfplervrlQILIPGHILGMFGLVMFGWTlkfrTHIVGPEIALFVMGFGVTTAFNITNGLLIDLHRDQ 447
Cdd:COG2814  274 --------------RLLLIGLLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

59-501

5.03e-38

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 143.49 E-value: 5.03e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 219 IFSGVLLVLFVFLFPETcrkvvgngsippqgvnrsvisciqqrklakLSPDEISTKPEKKKIAWPNPLATFRILAekesg 298
Cdd:cd17320  161 LLGLLLLLLVLLFLPET------------------------------LPEEKRKPLLSSLLRAYKRVLKNRRFLG----- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 299 iLLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVdwnfrryaRAIGMtitkgkqqdl 378
Cdd:cd17320  206 -YALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLV--------RRFGP---------- 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 379 snfpleRVRLQILIPghILGMFGLVMFGWTLKFRTHIVGPEIALFVMGFGVTTAFNITNGLLIDLHRDQPAAATAAVNFA 458
Cdd:cd17320  267 ------RRLLRLGLL--LLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFL 338

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 189203433 459 RCFMSAGGTAAIIPMchAMNPGWAFTFIAFIYVILLGVVLWVM 501
Cdd:cd17320  339 QFLIGALAGALVGLL--PNGTALPMGLLILVLGLLALLLLILL 379

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

59-361

2.86e-33

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 130.38 E-value: 2.86e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYlGWRSIFWFLA 218
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 219 IFSGVLLVLFVFLFPETCRKVVgngsippqgvnrsvisciqqrklaklsPDEISTKPEKKKIAWPNPLATFRILAekesg 298
Cdd:cd17474  160 ALIPVAFLAILFLLPEPKEKAK---------------------------SSSATKLRDLKKALRGRGLLTFLVSA----- 207

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 299 ilLMYNGLFFTGMmvtvSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRR 361
Cdd:cd17474  208 --FLYFFLYFAFL----TYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGA 264

MFS_1

pfam07690

Major Facilitator Superfamily;

62-443

1.45e-31

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.84 E-value: 1.45e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   62 VSISSLISPFGASMFLPAL-NVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLA 140
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  141 LQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIF 220
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  221 sgvllvlfvflfpetcrkvvgngsippqgvnrSVISCIqqrkLAKLSPDEISTKPEKKKIAWPNPLATFRILAEKESGIL 300
Cdd:pfam07690 161 --------------------------------SLLAAV----LLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  301 LMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRryaraigmtitkgkqqdlsn 380
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR-------------------- 264

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433  381 fpleRVRLQILIPGHILGMFGLVMFGWTLKFRTHIVgpeiALFVMGFGVTTAFNITNGLLIDL 443
Cdd:pfam07690 265 ----RRRLLLALLLLILAALGLLLLSLTLSSLWLLL----ALLLLGFGFGLVFPALNALVSDL 319

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

55-220

2.24e-31

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 123.00 E-value: 2.24e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSI 134
Cdd:COG0477   12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:COG0477   92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171


                 ....*.
gi 189203433 215 WFLAIF 220
Cdd:COG0477  172 LINAPL 177

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

62-371

5.74e-31

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 123.84 E-value: 5.74e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  62 VSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL 141
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 142 QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 222 GVLLVLFVFLFPETcrkvvgngsippqgvnrsvisciqqrklaklspdeISTKPEKKKIAWPNPLATFRILAEKESGILL 301
Cdd:cd17325  161 LLALVLALLLLPEP-----------------------------------RPPPNKRAVSAARLRSGLRLLLRDRRLLALF 205

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 302 MYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGMTIT 371
Cdd:cd17325  206 LAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

58-355

3.05e-30

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 122.11 E-value: 3.05e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   58 IIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNI 137
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  138 GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL 217
Cdd:TIGR00710  86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  218 AIFSGVLLVLFVFLFPETCRKvvgngsippqgVNRSVISCIQQRKLAKLspdeistkpeKKKIAWPNPLATfrilaekes 297
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPY-----------EARIQISTYFETFLLLL----------KSKMFWGYALIY--------- 215

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433  298 gillmynGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVV 355
Cdd:TIGR00710 216 -------GASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFI 266

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

59-499

8.86e-29

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 117.27 E-value: 8.86e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLIspFGASMFLPA--LNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGN 136
Cdd:cd17324    1 LLALALAAFA--IGTTEYVIQglLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 137 IGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWF 216
Cdd:cd17324   79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 217 LAIFSGvllvlfvflfpetcrkvvgngsippqgvnrsVISCIQQRKLAKLspdeistkPEKKKIAWPNPLATFRILAEKE 296
Cdd:cd17324  159 IAVLAL-------------------------------LAALLLWRLLPSL--------PPKKPGSLGLLSSLLLLLRNPR 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 297 SGILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRyaraigmtitkgkqq 376
Cdd:cd17324  200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR--------------- 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 377 dlsnfplervrlQILIPGHILGMFGLVMFGWTlkfrTHIVGPEIALFVMGFGVTTAFNITNGLLIDLHRDQPAAATAAVN 456
Cdd:cd17324  265 ------------ALLIALLLLAAALLLLTLLG----PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYL 328

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 189203433 457 FarCFMSAGGTAAIIPMCHAMNPGWAFTFIAFIYVILLGVVLW 499
Cdd:cd17324  329 A--AYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

62-221

2.38e-26

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 110.34 E-value: 2.38e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  62 VSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL 141
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 142 QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

2_A_01_02

TIGR00880

Multidrug resistance protein;

98-235

4.16e-26

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 103.50 E-value: 4.16e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   98 ITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSA 177
Cdd:TIGR00880   4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433  178 ERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFSGVLLVLFVFLFPET 235
Cdd:TIGR00880  84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

79-471

2.04e-24

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 104.97 E-value: 2.04e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  79 ALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVG 158
Cdd:cd17503   18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 159 GTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFlaifsgvllvlfvflfpetcrk 238
Cdd:cd17503   98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI---------------------- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 239 vvgngSIPPQGVnrsvisciqqrklaklspdeistkpekkkIAWPNPLATFRILAEKESGILLMYNGLFFTGMMVTVSAI 318
Cdd:cd17503  156 -----NLPIGIL-----------------------------ALLLAPLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLL 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 319 PTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWnfrryaraIGMTITkgkqqdlsnfplervrlqiLIPGHILG 398
Cdd:cd17503  202 PLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK--------FGPRLL-------------------LLAGLLLL 254

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189203433 399 MFGLVMFGWtlkFRTHIVGPEIA--LFVMGFGVTTAF-NITNGLLIDLHRDQPAAATAAVNFARCFMSAGGTAAII 471
Cdd:cd17503  255 ALGTLLLAF---LTPDTSLWLIIlpLFIRGLGMGLVFmPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

52-221

3.16e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 98.40 E-value: 3.16e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  52 KGMKTWIIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVI 131
Cdd:COG2271    5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 132 YSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWR 211
Cdd:COG2271   85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164

                        170
                 ....*....|
gi 189203433 212 SIFWFLAIFS 221
Cdd:COG2271  165 AAFLILGLPG 174

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

62-498

4.00e-21

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.19 E-value: 4.00e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  62 VSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL 141
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 142 QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYL--GWRSIFWFLAI 219
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 220 FSGVLLVLFVFLFPETcrkvvgngsippqgvnrsvisciQQRKLAKLSPDEISTKPEKKKIAWPNPLATfrilaekesgI 299
Cdd:cd06174  161 LALLAAILLLLVVPDP-----------------------PESARAKNEEASSKSVLKLLKRVLKNPGLW----------L 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 300 LLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGMtitkgkqqdls 379
Cdd:cd06174  208 LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG----------- 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 380 nfplervrlqilipghiLGMFGLVMFGWTLKFRTHIVGpeIALFVMGFGVTTAFNITNGLLIDLHRdqPAAATAAVNFAR 459
Cdd:cd06174  277 -----------------LLLMALGLALLLLAPSLLLLL--LLLLLLGFGLGGLLPLSFALIAELFP--PEIRGTAFGLLN 335

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 189203433 460 CFMSAGGTAA--IIPMCHAMNPGWAFTFIAFIYVILLGVVL 498
Cdd:cd06174  336 TFGFLGGAIGplLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

67-221

4.30e-21

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 94.95 E-value: 4.30e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  67 LISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYT 146
Cdd:cd17504    6 LAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189203433 147 ALLILRMLQAVGGtAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17504   86 VLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

59-221

1.96e-19

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.94 E-value: 1.96e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNV-LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNI 137
Cdd:cd17325  201 LLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 138 GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL 217
Cdd:cd17325  281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360


                 ....
gi 189203433 218 AIFS 221
Cdd:cd17325  361 AALL 364

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

57-220

4.55e-18

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.09 E-value: 4.55e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  57 WIIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGN 136
Cdd:COG2223    5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 137 IGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWF 216
Cdd:COG2223   85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164


                 ....
gi 189203433 217 LAIF 220
Cdd:COG2223  165 LGIL 168

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

98-216

1.53e-17

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 83.77 E-value: 1.53e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  98 ITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSA 177
Cdd:cd17502   36 GTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPR 115

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 189203433 178 ERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWF 216
Cdd:cd17502  116 ERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI 154

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

62-371

1.72e-17

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 84.18 E-value: 1.72e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  62 VSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL 141
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 142 QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17489   81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 222 gvllvlfvflfpetcrkVVGngsippqgvnrsvISCIQQRKLAKLSPDEISTKPEKKKIAWPNPLATFrilaekeSGILL 301
Cdd:cd17489  161 -----------------LLA-------------LLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLP-------PALIL 203

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 302 MyngLFFTGMMVTVSAIPtLFYEAYGLDelHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGMTIT 371
Cdd:cd17489  204 F---LASIAYGAISTFLP-LYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLL 267

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

62-221

2.12e-17

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 83.78 E-value: 2.12e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  62 VSISSLISPFGASMFLPALNVLS---DVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVrefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LALQTNYTALLILRMLQAVGGtAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTG-GNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159


                 ...
gi 189203433 219 IFS 221
Cdd:cd17330  160 ALA 162

emrD

PRK11652

multidrug transporter EmrD;

58-236

2.95e-17

multidrug transporter EmrD;

Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 83.80 E-value: 2.95e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  58 IIFLVSISSLispfGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNI 137
Cdd:PRK11652  13 LVLLVAVGQM----AQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 138 GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL 217
Cdd:PRK11652  89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFL 168

                        170
                 ....*....|....*....
gi 189203433 218 AIFSGVLLVLFVFLFPETC 236
Cdd:PRK11652 169 LLLGAGVTFSMARWMPETR 187

PRK11043

Bcr/CflA family multidrug efflux MFS transporter;

54-221

8.15e-17

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 82.63 E-value: 8.15e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  54 MKTWIIFLVSISSLiSPFG---ASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFV 130
Cdd:PRK11043   1 MQPSKGFLVYLAGL-SMLGflaTDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 131 IYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVAD--ISTSAER--GTYMGyaqagiLMG--PAFGPAIGGLL 204
Cdd:PRK11043  80 LFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDryPAQKANRvfATIMP------LVAlsPALAPLLGAWL 153

                        170
                 ....*....|....*..
gi 189203433 205 AQYLGWRSIFWFLAIFS 221
Cdd:PRK11043 154 LNHFGWQAIFATLFAIT 170

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

70-238

9.07e-17

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 81.88 E-value: 9.07e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  70 PFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALL 149
Cdd:PRK11102   4 PLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 150 ILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFSGVLLVLFV 229
Cdd:PRK11102  84 YMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163


                 ....*....
gi 189203433 230 FLFPETCRK 238
Cdd:PRK11102 164 FFIPETLPK 172

efflux_EmrB

TIGR00711

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...

62-356

5.71e-16

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]

Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 80.50 E-value: 5.71e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   62 VSISSLISPFGASMflpalnvlsdvlhitpSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL 141
Cdd:TIGR00711  23 VAIPTIAGDLGSSL----------------SQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  142 QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:TIGR00711  87 APNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  222 GVLLVLFVFLFPETCRKVVGNG-------SIPPQGVNRSVISciQQRKLAKLSPDEISTKPEKKKIAW----------PN 284
Cdd:TIGR00711 167 IIVVVVAFFILPRDKPAASENFdflglllLSVGLGSLLYGLS--EGPERGWFDSNEILILSITGLVAIiafvvweltdDN 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189203433  285 PLATFRILAEKESGILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVD 356
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGD 316

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

56-221

1.01e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 75.68 E-value: 1.01e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  56 TWIIFLVSISSLISPFGASMFLPALnvLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSD--NSGRRLTFIICFVIYS 133
Cdd:COG2271  182 FWLLALAYFLVYFALYGFLTWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 134 IGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSI 213
Cdd:COG2271  260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339


                 ....*...
gi 189203433 214 FWFLAIFS 221
Cdd:COG2271  340 FLLLAALA 347

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

61-370

7.05e-14

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 73.38 E-value: 7.05e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  61 LVSISSLISPFGASMFlPALNVLSDVLH-ITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGL 139
Cdd:cd17473    4 LLLASTLTVMAGAAIA-PALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 140 ALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQyLGWRSIFWFLAi 219
Cdd:cd17473   83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 220 FSGVLLVLFVFLFPETcrkvvgngsippqgvnrsvisciQQRKLAKLSPDEISTKPEKKKIAWPNPLATFrilaekesgi 299
Cdd:cd17473  161 LALPVLILVLLFLPEP-----------------------ARKSKSAASPGAATAAALPWKRVLPIYFLAF---------- 207

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189203433 300 llmyngLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGMTI 370
Cdd:cd17473  208 ------LAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL 272

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

79-221

1.56e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.39 E-value: 1.56e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   79 ALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVG 158
Cdd:TIGR00895  39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433  159 GTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAP 181

MFS_MFSD9

cd17390

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...

71-209

6.62e-13

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 69.95 E-value: 6.62e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  71 FGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLI 150
Cdd:cd17390   10 FGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFL 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 151 LR-MLQAVGGTaaIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLG 209
Cdd:cd17390   90 SRiPLGIFKHT--QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG 147

MFS_Amf1_MDR_like

cd17476

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...

60-219

2.67e-12

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 68.44 E-value: 2.67e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  60 FLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGL 139
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 140 ALQTNYTALLILRMLQAVGGTAAIALTMAVVADI-STSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTyPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160


                 .
gi 189203433 219 I 219
Cdd:cd17476  161 I 161

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

55-222

2.89e-12

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.22 E-value: 2.89e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASMFLPALnvLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSD-NSGRRLTFIICFVIYS 133
Cdd:cd06174  204 GLWLLLLAIFLVNLAYYSFSTLLPLF--LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMA 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 134 IGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGG-LLAQYLGWRS 212
Cdd:cd06174  282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGLTG 361

                        170
                 ....*....|
gi 189203433 213 IFWFLAIFSG 222
Cdd:cd06174  362 AFLVLAVLLL 371

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

89-219

4.34e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.61 E-value: 4.34e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  89 ITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMA 168
Cdd:cd17365   31 LSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAIT 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 189203433 169 VVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAI 219
Cdd:cd17365  111 LVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGV 161

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

71-221

7.61e-12

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 66.86 E-value: 7.61e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  71 FGASMFLPALNVLSDVL-HITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALL 149
Cdd:cd17472   10 LGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLI 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189203433 150 ILRMLQAVGGTAAIAltMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17472   90 LGRALQGSGAISSVV--MALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILS 159

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

87-221

1.06e-11

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.47 E-value: 1.06e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  87 LHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQ--AVGGTAAIA 164
Cdd:cd17316   31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQgiGIGGEYPGA 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189203433 165 LTMavVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLL----AQYLGWRSIFWFLAIFS 221
Cdd:cd17316  111 STY--VAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGALPA 169

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

63-221

1.77e-11

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 65.65 E-value: 1.77e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  63 SISSLISPFGASMFLPALNV-LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSD-NSGRRLTFIICFVIYSIGNIGLA 140
Cdd:cd17471    2 LLATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDrGGDRKPLILLALLAGALGYLLFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 141 LQTNYTALLILRMLQAVGGTAAIALTMAV---VADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL 217
Cdd:cd17471   82 FLRNYWVLLLVGVVLLSLGAAAFPQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLA 161


                 ....
gi 189203433 218 AIFS 221
Cdd:cd17471  162 ALLY 165

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

87-221

3.77e-11

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 64.51 E-value: 3.77e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  87 LHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALT 166
Cdd:cd17319   33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGA 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 189203433 167 MAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17319  113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLG 167

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

29-221

4.12e-11

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.49 E-value: 4.12e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  29 VERVGVQPGLQRTLSEPPYSVFSKGMKTWIIflvsISSLISPFGASMFLPALNVLSdvLHITPSQVNISITTYMIAQAIA 108
Cdd:cd17370  177 VKEYPRPPKLRKKSKKTSLKKLPKAFWLYLL----AVALFALGNFSFAFLILRAQE--LGLSAALIPLLYALFNLVYALA 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 109 PAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQA 188
Cdd:cd17370  251 AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT 330

                        170       180       190
                 ....*....|....*....|....*....|...
gi 189203433 189 GILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17370  331 VVGIGWLLASLIAGYLWDLISPSAAFLFSAVLA 363

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

55-212

6.78e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.54 E-value: 6.78e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSIssLISPFGASMFLPALN-VLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYS 133
Cdd:COG2211  228 RPFLLLLLAY--LLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 134 IGNIGLAL--QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAE-------RGTYMGYAQAGILMGPAFGPAIGGLL 204
Cdd:COG2211  306 LGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLL 385


                 ....*...
gi 189203433 205 AQYLGWRS 212
Cdd:COG2211  386 LALFGYVA 393

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

74-219

1.15e-10

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.48 E-value: 1.15e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  74 SMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRM 153
Cdd:cd17371   16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 154 LQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYL----GWRSIFWFLAI 219
Cdd:cd17371   96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLFLLGAL 165

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

62-219

1.34e-10

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.96 E-value: 1.34e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  62 VSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL 141
Cdd:cd17478    1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433 142 QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAeRGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAI 219
Cdd:cd17478   81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII 157

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

56-193

1.35e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.07 E-value: 1.35e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  56 TWIIFLVSISSLISPFGASMFLPALnvLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIG 135
Cdd:COG2814  209 LLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433 136 NIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMG 193
Cdd:COG2814  287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

56-220

1.99e-10

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 62.23 E-value: 1.99e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  56 TWIIFLVSISSLISPFGASMFLPALnvLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIG 135
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 136 NI--GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYA-QAGILMGPAFGPAIGGLLAQYLGWRS 212
Cdd:cd17316  257 ALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSyNLGRLGGGGAPPLIALLLASTGGTGV 336


                 ....*...
gi 189203433 213 IFWFLAIF 220
Cdd:cd17316  337 PALILALL 344

MFS_SLC18A1_2_VAT1_2

cd17384

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...

103-221

7.11e-10

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 60.66 E-value: 7.11e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 103 IAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADIST-SAERGT 181
Cdd:cd17384   42 LVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPdDKERGK 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189203433 182 YMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17384  122 AMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLA 161

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

55-221

1.22e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 60.28 E-value: 1.22e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASMFLPalNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSI 134
Cdd:COG2223  206 RFWLLSLLYFGTFGSFIGFSSWLP--PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLAL-QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLG-WRS 212
Cdd:COG2223  284 GLLLLALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTA 363


                 ....*....
gi 189203433 213 IFWFLAIFS 221
Cdd:COG2223  364 AFLVFAVLA 372

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

60-222

1.51e-09

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 60.33 E-value: 1.51e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  60 FLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISiTTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGL 139
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWIS-TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 140 ALQTNYTALLILRMLQAVGgTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQ--YLGWRSIFWFL 217
Cdd:cd06179   80 GTAKSVNMLIGGQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYIN 158


                 ....*
gi 189203433 218 AIFSG 222
Cdd:cd06179  159 AIFNA 163

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

60-220

1.88e-09

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 59.59 E-value: 1.88e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  60 FLVSIS-SLISPFgasmfLPaLNVlSDVLHITPSQVNI------SITTymIAQAIAPAFLGTLSDNSGRRLTFIICFVIY 132
Cdd:cd17391    6 FFTGIGfSLIAPF-----LP-LYI-EQLGVTSGGLVELwsglafSSTF--LVSAIFSPIWGRLADRYGRKPMLLRASLGM 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 133 SIGNIGLALQTNYTALLILRMLQAV-GGTAAIALTMavvadISTSAER---GTYMGYAQAGILMGPAFGPAIGGLLAQYL 208
Cdd:cd17391   77 AIVIGLMAFVTNVWQLLILRLLQGVfSGYVPNATAL-----IASQTPKeksGWALGTLSTGVVAGTLIGPLLGGFLADLF 151

                        170
                 ....*....|..
gi 189203433 209 GWRSIFWFLAIF 220
Cdd:cd17391  152 GIRNVFFITGGL 163

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

58-219

2.11e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 2.11e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  58 IIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNI 137
Cdd:cd06173  210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 138 GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL 217
Cdd:cd06173  290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369


                 ..
gi 189203433 218 AI 219
Cdd:cd06173  370 GA 371

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

98-235

2.33e-09

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 59.19 E-value: 2.33e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  98 ITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGtAAIALTMAVVADISTSA 177
Cdd:cd17388   44 LALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITG-ATGAVAAAYIADVTPPE 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433 178 ERGTYMGYAQAGILMGPAFGPAIGGLLAQYlGWRSIFWFLAIFSGVLLVLFVFLFPET 235
Cdd:cd17388  123 QRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLLGLFVLPES 179

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

78-221

3.26e-09

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 58.73 E-value: 3.26e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  78 PALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAV 157
Cdd:COG2807   39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189203433 158 GGTAAIALTMAVVADiSTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:COG2807  119 GIAVGNVLLPGLIKR-WFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLA 181

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

51-503

3.48e-09

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 3.48e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  51 SKGMKTWIIFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFV 130
Cdd:COG0738    2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 131 IYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADIStSAERGTYMGYAQAGILMGPAFGPAIGGLLAQY--- 207
Cdd:COG0738   82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 208 LGWRSIFWFLAIFSGVLLvlfvflfpetcrkvvgngsippqgvnrsVISCIQQRKLAKLSPDEISTKPEKKKIAWPNPLA 287
Cdd:COG0738  161 LSWHLPYLILAVLLLLLA----------------------------LLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 288 TFrilaekesGILLMyngLFFTGMMVTV-SAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWnfrryarai 366
Cdd:COG0738  213 LL--------GGLAI---FLYVGAEGAIgDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR--------- 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 367 gmtitkgkqqdlsnFPLERVrlqiLIPGHILGMFGLVMFGWTlkfrTHIVGPEIALFVMGFGVTTAFNITNGLLIDlhrD 446
Cdd:COG0738  273 --------------FGPVRL----LRLSALLAAVGLLLALLA----PGPWLALIGLALVGLGLSLMFPTIFSLALD---G 327

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189203433 447 QPAAATAAVNFARCFMSAGGtaAIIP-----MCHAMNPGWAFTFIAFIYVILLGVVLWVMRN 503
Cdd:COG0738  328 LGKRTAAAVSAVLIMGIVGG--AIGPpligfLADAFGLRAAFLVPLVCYLLILLLALALKRK 387

2A0112

TIGR00891

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ...

76-406

3.90e-09

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273324 [Multi-domain] Cd Length: 405 Bit Score: 58.74 E-value: 3.90e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   76 FLPALNV--LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRM 153
Cdd:TIGR00891  29 FLVALVLaeVAGEFGLTTVDAASLISAALISRWFGALMFGLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  154 LQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLG--WRSIFWFlAIFSGVLLVLFVFL 231
Cdd:TIGR00891 109 VIGIGMGGEYGSSAAYVIESWPKHLRNKASGLLISGYAVGAVVAAQVYSLVVPVWGdgWRALFFI-SILPIIFALWLRKN 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  232 FPETcrkvvgngsippqgvnRSVISCIQQRKLAKLSPDEISTKPEKKKIAWPNPLATFRILAEKE--SGILLMYNGLFFT 309
Cdd:TIGR00891 188 IPEA----------------EDWKEKHAGKALVRTMVDILYGGEHRIANIVMTLAAAMVQSAGKRwpTFVYLVVLVLFAN 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  310 GMMVTVSAI-PTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGMTITKgkqqdLSNFPLERVRL 388
Cdd:TIGR00891 252 LYSHPIQDLlPTYLKADLGLSPHTVANIVVFSNIGAIVGGCVFGFLGDWLGRRKAYVCSLLAGQ-----LLIIPVFAIGA 326

                         330
                  ....*....|....*...
gi 189203433  389 QILIPGhiLGMFGLVMFG 406
Cdd:TIGR00891 327 NVAVLG--LGLFFQQMLV 342

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

55-221

4.96e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 58.39 E-value: 4.96e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASM-FLPalnVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNS-GRRLTFIICFVIY 132
Cdd:cd17490  195 KLLFFSLLAILQQMITFSTTFgFTP---LIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKlGERNTIIIGFLLL 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 133 SIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRS 212
Cdd:cd17490  272 GAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT 351


                 ....*....
gi 189203433 213 IFWFLAIFS 221
Cdd:cd17490  352 GFFVIGVIA 360

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

76-220

4.97e-09

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 4.97e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  76 FLPalNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDN-SGRRLTFIICFVIYSIGNIGLALQTNYTALLILRML 154
Cdd:cd17474  220 YLP--FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVL 297

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189203433 155 QAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIF 220
Cdd:cd17474  298 FGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAI 363

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

59-219

2.01e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.47 E-value: 2.01e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNV-LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNI 137
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 138 GLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYlGWRSIFWFL 217
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAA 159


                 ..
gi 189203433 218 AI 219
Cdd:cd17329  160 AV 161

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

64-370

2.02e-08

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.47 E-value: 2.02e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  64 ISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL-- 141
Cdd:cd06173    6 LAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALla 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 142 ---QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd06173   86 llgSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 219 IFsgvllvlfvflfpetcrkvvgngsippqgvnrSVISCIQqrkLAKLSPDEISTKPEKKKIAWPNPLATFRILAE-KES 297
Cdd:cd06173  166 LS--------------------------------FLLSALL---LLFIRRPPPAAPGESSSLLLRDLREGLRYLRRsPLL 210

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 298 GILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGMTI 370
Cdd:cd06173  211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL 283

PRK10473

MdtL family multidrug efflux MFS transporter;

67-222

4.18e-08

MdtL family multidrug efflux MFS transporter;

Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 55.41 E-value: 4.18e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  67 LISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYT 146
Cdd:PRK10473  13 LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSS 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189203433 147 ALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFSG 222
Cdd:PRK10473  93 LFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGI 168

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

83-221

5.33e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.93 E-value: 5.33e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  83 LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAA 162
Cdd:cd17328   25 IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASY 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 163 IALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQY-LGWRSIFWFLAIFS 221
Cdd:cd17328  105 SPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLG 164

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

79-219

5.57e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 5.57e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  79 ALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVG 158
Cdd:cd17359   23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 189203433 159 GTAAIALTMAVVADISTSAERGTYMGYAQAGILMGP--------AFGPAIGGLLAQYLGWRSIFWFLAI 219
Cdd:cd17359  103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQllayivnyLIANAGGADWLGAEGWRWMLGLEAI 171

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

57-220

1.00e-07

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.12 E-value: 1.00e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  57 WIIFLVSISSLISPFGASMFLPALNV-LSDVLHITPSQVNISITTYMIAQAIAPAFL-GTLSDNSGRRLTFIICFVIYSI 134
Cdd:cd17330  174 PPLRRLLLVYFLIALAFAGLESVFSLfLKDRFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAII 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:cd17330  254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333


                 ....*.
gi 189203433 215 WFLAIF 220
Cdd:cd17330  334 LLAAGL 339

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

34-220

1.29e-07

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.81 E-value: 1.29e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  34 VQPGLQRTLSEPPYSVFSKGmktwIIFLVSISSLISPFGASMFLPALNVLsdVLHITPSQVNISITTYMIAQA------I 107
Cdd:cd17391  182 VEKKKMVSTKEVWNSVPNPS----LLISLFVTTFIIQLANQSIEPILTLY--IRQLMGDASNLAFISGLVFSAtgvsslL 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 108 APAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQ 187
Cdd:cd17391  256 SAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQ 335

                        170       180       190
                 ....*....|....*....|....*....|...
gi 189203433 188 AGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIF 220
Cdd:cd17391  336 SFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL 368

PRK15402

MdfA family multidrug efflux MFS transporter;

75-235

1.38e-07

MdfA family multidrug efflux MFS transporter;

Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 53.79 E-value: 1.38e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  75 MFLPA-LNVLSDvLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRR-------LTFII-CFVIYSIGNIGLalqtny 145
Cdd:PRK15402  31 MIQPGmLAVVED-FNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRpvmlagvAFFILtCLAILLAQSIEQ------ 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 146 taLLILRMLQAVG-------GTAAIALT---------MAVVADIStsaergtymgyaqagiLMGPAFGPAIGGLLAQYLG 209
Cdd:PRK15402 104 --FTLLRFLQGIGlcfigavGYAAIQESfeeadaikiTALMANVA----------------LLAPLLGPLVGAALIHVLP 165

                        170       180
                 ....*....|....*....|....*.
gi 189203433 210 WRSIFWFLAIFSGVLLVLFVFLFPET 235
Cdd:PRK15402 166 WRGMFVLFAALAALSFFGLWRAMPET 191

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

54-222

2.40e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.95 E-value: 2.40e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  54 MKTWIIFLVSISSLISPFGASMFLPALNVLSDV----LHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICF 129
Cdd:cd17477  181 ISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLyglrLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 130 VIYSIGNIGLALQTNYTALLILrMLQAVGGTAAI--ALTMAVVADISTSAERGTymgyAQAGILM----GPAFGPAIGGL 203
Cdd:cd17477  261 LLGALAALLLPLVPGLPLALLV-LLFLWGGAAGPlyTLALALAGDRLPGDELVA----ANAALLLlyglGSVIGPLLAGA 335

                        170
                 ....*....|....*....
gi 189203433 204 LAQYLGWRSIFWFLAIFSG 222
Cdd:cd17477  336 LMDAFGPHGLFLFLAAVAL 354

Sugar_tr

pfam00083

Sugar (and other) transporter;

101-222

2.60e-07

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 53.04 E-value: 2.60e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  101 YMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL---QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSA 177
Cdd:pfam00083  55 FSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAakgKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKK 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 189203433  178 ERGTYMGYAQAGILMGPAFGPAIGGLLAQY---LGWRSIFWFLAIFSG 222
Cdd:pfam00083 135 LRGALGSLYQLAITFGILLAYIFGLGLNKTsnsDGWRIPLGLQLVPAL 182

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

83-222

2.96e-07

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 2.96e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  83 LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAA 162
Cdd:cd17329  227 VVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLV 306

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 163 IALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFSG 222
Cdd:cd17329  307 FPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGL 366

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

58-221

3.29e-07

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.60 E-value: 3.29e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  58 IIFLVSIsslisPFGA-SMFLPALnvlsdVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGN 136
Cdd:cd17489  202 ILFLASI-----AYGAiSTFLPLY-----AAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGL 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 137 IGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWF 216
Cdd:cd17489  272 LLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLL 351


                 ....*
gi 189203433 217 LAIFS 221
Cdd:cd17489  352 AAVVV 356

PRK10504

putative transporter; Provisional

79-214

4.74e-07

putative transporter; Provisional

Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 52.43 E-value: 4.74e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  79 ALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVG 158
Cdd:PRK10504  32 ALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 189203433 159 GTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:PRK10504 112 GAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIF 167

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

55-220

6.71e-07

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 6.71e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASMFLPALnvLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSI 134
Cdd:cd17324  199 RLRLAYLITFLLFGGFFALYTYLAPF--LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAeRGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:cd17324  277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355


                 ....*.
gi 189203433 215 WFLAIF 220
Cdd:cd17324  356 WVGAAL 361

MFS_SLC22A18

cd17331

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...

67-220

7.70e-07

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.45 E-value: 7.70e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  67 LISPFGASMFLPALNVLS-DVLHITPSQVNISITTYMIAQAIAPAFL-GTLSDNSGRRLTFIICFVIYSIGNIGLALQTN 144
Cdd:cd17331  217 LLSGLPIGMFQSMFSLVAmDFFGLTPEENGYLMSYAGVLGMVVQGLLvGPLTKRFGERSLLKLSVALLAIGYLLLAFVTT 296

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189203433 145 YTALLILRMLQAVGGT-AAIALTMAVVADISTSaERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSiFWFLAIF 220
Cdd:cd17331  297 VWQLLVLLLPLVIGGSvLYTVITSLLTKAVPPE-DTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPS-FGLLGAA 371

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

101-221

8.86e-07

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 8.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 101 YMIAQAIAPAFLGTLSD-NSGRRLTFIICFVIYSIGNIGLALQTNYTALLILrMLQAVGGTAAIALTMAVVADIS-TSAE 178
Cdd:COG2807  259 FQLAGIPGSLLVPLLADrLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLRArTPAE 337

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 189203433 179 RGTYMGYAQAGILMGPAFGPAIGGLLAQYLG-WRSIFWFLAIFS 221
Cdd:COG2807  338 AAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALA 381

PRK11551

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

110-215

9.74e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.12 E-value: 9.74e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 110 AFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAG 189
Cdd:PRK11551  68 LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCG 147

                         90       100
                 ....*....|....*....|....*.
gi 189203433 190 ILMGPAFGPAIGGLLAQYLGWRSIFW 215
Cdd:PRK11551 148 VPFGGALASVIGVLAAGDAAWRHIFY 173

MFS_1

pfam07690

Major Facilitator Superfamily;

59-198

9.77e-07

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 9.77e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   59 IFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433  139 LAL---QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGP 198
Cdd:pfam07690 282 LLLlslTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

82-209

1.41e-06

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 1.41e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  82 VLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTA 161
Cdd:cd17473  223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL 302

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 189203433 162 AIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLG 209
Cdd:cd17473  303 LLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350

MFS_MFSD10

cd17389

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...

101-222

1.43e-06

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 50.74 E-value: 1.43e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 101 YMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMlqaVGG--TAAIALTMAVVADISTSAE 178
Cdd:cd17389   73 FSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRI---VGGisKGNVSLSTAIVADVTSPKK 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 189203433 179 RGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFL--AIFSG 222
Cdd:cd17389  150 RSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSmpALFAL 195

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

57-220

1.53e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.35 E-value: 1.53e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  57 WIIFLVSISSLISPFGASM-FLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIG 135
Cdd:cd17355    2 WVVLAVTFLILILSWGIRYyFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 136 NIGLALQTNYTALLILRMLQAVGGTAAIALTM-AVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:cd17355   82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161


                 ....*.
gi 189203433 215 WFLAIF 220
Cdd:cd17355  162 LVLALL 167

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

71-221

1.56e-06

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.30 E-value: 1.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  71 FGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIIC-FVIYSIGNIGLALQTNYTALL 149
Cdd:cd17490   10 FSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLL 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189203433 150 ILRMLQAVGGTAAIALTMAVVADISTSaERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17490   90 IARFLSGIAAATWVSFTVLYASYFPPD-EAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAG 160

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

78-221

1.98e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 49.88 E-value: 1.98e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  78 PALNVLSDVLHI--TPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQ 155
Cdd:cd17315   18 GALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433 156 AVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYL--GWRSIFWFLAIFS 221
Cdd:cd17315   98 GLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPA 165

MFS_SLC18A3_VAChT

cd17383

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...

103-221

2.56e-06

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 49.62 E-value: 2.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 103 IAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTS-AERGT 181
Cdd:cd17383   41 IVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEeAERSK 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189203433 182 YMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17383  121 ALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVC 160

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

51-370

6.25e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 6.25e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  51 SKGMKTWIIFLVSISSLISPFGASMFLPALNV-LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNS----GRR--- 122
Cdd:COG2211    4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRrpw 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 123 ---------LTFIICFVIYSIGNIGLALqtnytALLILRMLQAVGGTAAIALTMAVVADISTS-AERGTYMGYAQAGILM 192
Cdd:COG2211   84 iligaiplaLSFVLLFTAPDLSPTGKLI-----YALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 193 GPAFGPAIGGLLAQYL------GWRSIFWFLAIFSGVLLVLFVFLFPETcrkvvgngsippqgvnrsvisciqqrklakl 266
Cdd:COG2211  159 GGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKER------------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 267 spdeISTKPEKKKIawpnpLATFR-ILAEKESGILLMYNGLFFTGMMVTVSAIPTLFYEAYGLDELHIGLCYISNGVAAL 345
Cdd:COG2211  208 ----PVPEEEKVSL-----KESLKaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAAL 278

                        330       340
                 ....*....|....*....|....*
gi 189203433 346 VSSLTMGRVVDWNFRRYARAIGMTI 370
Cdd:COG2211  279 LGAPLWPRLAKRFGKKKAFIIGLLL 303

MFS_PLT

cd17437

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...

61-211

1.25e-05

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 47.78 E-value: 1.25e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  61 LVSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLA 140
Cdd:cd17437    1 LASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189203433 141 LQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQ----AGILMGPAFGPAIGGLLAQyLGWR 211
Cdd:cd17437   81 VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEifinIGILLGYVSNYAFSGLPLH-VGWR 154

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

76-368

1.27e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 47.37 E-value: 1.27e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433   76 FLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQ 155
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  156 AVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGL-LAQYLGWRSIFWF---LAIFSGVLLVLFVFL 231
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVpgiIAIIVSLICFLLLRD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  232 FPETCRkvvgngsippqgvnrsvisciqQRKLAKLSPDEISTKPEKKkiawPNPLATFRILAEKESG---ILLMYNGLFF 308
Cdd:TIGR00881 174 SPQSCG----------------------LPPAEEMPNEEPDGDAEKK----EEELTKKQIFLQYVLLnkvLWYISLGYVF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189203433  309 TGMMVT--VSAIPTLFYEAYGLDELHIGLCYISNGVAALVSSLTMGRVVDWNFRRYARAIGM 368
Cdd:TIGR00881 228 VYVVRTgiLDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAV 289

MFS_GLUT10_12_Class3_like

cd17362

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...

113-218

1.66e-05

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 47.35 E-value: 1.66e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 113 GTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILM 192
Cdd:cd17362   60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVL 139

                         90       100
                 ....*....|....*....|....*..
gi 189203433 193 GPAFGPAIGGLLAQ-YLGWRSIFWFLA 218
Cdd:cd17362  140 GILLGYVSGYAFADvVGGWRYMYGLAA 166

MFS_GLUT12_Class3

cd17435

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...

63-214

2.15e-05

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 46.71 E-value: 2.15e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  63 SISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQ 142
Cdd:cd17435    7 AVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCS 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 143 TNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYL-GWRSIF 214
Cdd:cd17435   87 VSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVSnGWKYMF 159

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

83-219

2.72e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.46 E-value: 2.72e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  83 LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALL-ILRMLQAVGGTA 161
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLvLLFLVGAGYGSV 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 189203433 162 AIALTMAVVADISTSaERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAI 219
Cdd:cd17475  102 QPGGGRAIMRWFPPR-ERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGL 158

PRK15403

multidrug efflux MFS transporter MdtM;

64-261

2.90e-05

multidrug efflux MFS transporter MdtM;

Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 46.36 E-value: 2.90e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  64 ISSLISPFGASMFLPALNVLSDVLH------ITPSQVNI-------------SITTYMIAQAIAPAFLGTLSDNSGRRLT 124
Cdd:PRK15403   4 MPRFFARHAATLFFPMALILYDFAAylttdlIQPGIINVvrdfnadvslapaSVSLYLAGGMALQWLLGPLSDRIGRRPV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 125 FIICFVIYSIGNIGLALQTNYTALLILRMLQ-----------------AVGGTAAIALtMAVVADIstsaergtymgyaq 187
Cdd:PRK15403  84 LITGALIFTLACAATLFTTSMTQFLIARFIQgtsicfiatvgyvtvqeAFGQTKGIKL-MAIITSI-------------- 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189203433 188 agILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFSGVLLVLFVFLFPETCRKvvGNGSIPPQGVNRSVISCIQQR 261
Cdd:PRK15403 149 --VLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKR--GAVPFSAKSVLRDFRNVFRNR 218

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

93-170

3.13e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.03 E-value: 3.13e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  93 QVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVG----GTAAIALTMA 168
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTsagiFTVGFVLGME 105


                 ..
gi 189203433 169 VV 170
Cdd:cd17317  106 IV 107

PRK03545

putative arabinose transporter; Provisional

57-220

3.21e-05

putative arabinose transporter; Provisional

Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 46.42 E-value: 3.21e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  57 WIIFLVSISSLIspFGASMFLP-ALnvLSDV---LHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIY 132
Cdd:PRK03545   9 LRVVTLALAAFI--FNTTEFVPvGL--LSDIaqsFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 133 SIGNIGLALQTNYTALLILRMlqavggtaAIALTMAVVADISTS-AERGTYMG-YAQA-GIL-MGPA----FGPAIGGLL 204
Cdd:PRK03545  85 IASHVLSALAWNFTVLLISRI--------GIAFAHAIFWSITASlAIRVAPAGkKAQAlSLLaTGTAlamvLGLPLGRVI 156

                        170
                 ....*....|....*.
gi 189203433 205 AQYLGWRSIFWFLAIF 220
Cdd:PRK03545 157 GQYLGWRTTFLAIGGG 172

PRK14995

SmvA family efflux MFS transporter;

50-214

6.38e-05

SmvA family efflux MFS transporter;

Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 45.49 E-value: 6.38e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  50 FSKGMKTWIIFLVSISSLISpfgASMFLPALNVLSDVLHITPSQV--NISITTYMIAQAIAPafLGTLSDNSGRRLTFII 127
Cdd:PRK14995   2 FRQWLTLVIIVLVYIPVAID---ATVLHVAAPTLSMTLGASGNELlwIIDIYSLVMAGMVLP--MGALGDRIGFKRLLML 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 128 CFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSA-ERGTYMGYAQAGILMGPAFGPAIGGLLAQ 206
Cdd:PRK14995  77 GGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEkQRNMALGVWAAVGSGGAAFGPLVGGILLE 156


                 ....*...
gi 189203433 207 YLGWRSIF 214
Cdd:PRK14995 157 HFYWGSVF 164

PRK09874

multidrug efflux MFS transporter MdtG;

66-218

8.04e-05

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 44.91 E-value: 8.04e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  66 SLISPFgASMFLPALNVLSDVLHITPSQVNISITtyMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNY 145
Cdd:PRK09874  31 SLVMPF-LPLYVEQLGVTGHSALNMWSGLVFSIT--FLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNI 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 146 TALLILRMLQAVGGtAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:PRK09874 108 WQFLILRALLGLLG-GFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITA 179

MFS_SLC17

cd17318

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...

139-221

9.84e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.92 E-value: 9.84e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLA 218
Cdd:cd17318  105 LAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFG 184


                 ...
gi 189203433 219 IFS 221
Cdd:cd17318  185 GLG 187

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

56-214

1.12e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.57 E-value: 1.12e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  56 TWIIFL-VSISSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSI 134
Cdd:cd17312    1 RWRIFLgVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIF 214
Cdd:cd17312   81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160

MFS_NRT2_like

cd17341

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...

60-220

1.48e-04

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.16 E-value: 1.48e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  60 FLVSISSLISPFGASMFLPALNV-LSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIG 138
Cdd:cd17341    1 LHLSWLSFFLGFMVWFLFAPLGPvIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 139 LAL-QTNYTALLILRMLQAVGGtAAIALTMAVVADISTSAERGTY-MGYAQAGILMGPA---FGPAI---GGLLAQYLGW 210
Cdd:cd17341   81 LALaVSSYWGLLVLGFLLGFAG-ANFASGQPWASFWFPKEKIGGAaGGIAGAGNMGVAVsqlLAPLIagaIVFDGGFVGW 159

                        170
                 ....*....|
gi 189203433 211 RSIFWFLAIF 220
Cdd:cd17341  160 RNAFFVPGIL 169

MFS_SLC22A18

cd17331

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...

99-221

1.79e-04

Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 43.75 E-value: 1.79e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  99 TTYMIAQAIAPAFLGTLSDNSGRRLTFIICF----VIYSIgnigLALQTNYTALLILRmLQAVGGTAAIALTMaVVADIS 174
Cdd:cd17331   42 TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFlssaLSYLL----LAFASSVPMLFLSR-LPSVFMHAMQAAQM-VVTDLT 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 189203433 175 TSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17331  116 DPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGS 162

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

57-221

1.89e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 43.75 E-value: 1.89e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  57 WIIF------LVSISSLISPFGASMFlpalnvlsdvlHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFV 130
Cdd:cd17353  219 WLMFflnataGLMLIGQAKPIGQEFA-----------GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 131 IYSIGNIGLAL-QTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLG 209
Cdd:cd17353  288 IQGVAMFLLPFiGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367

                        170
                 ....*....|..
gi 189203433 210 WRSIFWFLAIFS 221
Cdd:cd17353  368 YNAAFIIAAALS 379

MFS_SLC46

cd17386

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...

106-221

6.41e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 42.26 E-value: 6.41e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 106 AIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQT------NYTALLILRMLQAV--GGTAAIALTMAVVADISTSA 177
Cdd:cd17386   44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVyfttvpSVWWFYLSAIPLALfgGFTAFLSASFAYISDISSEK 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 189203433 178 ERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17386  124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALL 167

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

87-221

7.74e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.80 E-value: 7.74e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  87 LHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALT 166
Cdd:cd17335  228 LGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAA 307

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 189203433 167 MAVVADISTSAERGTYMGYAQAGIL-MGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17335  308 VSYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAA 363

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

88-222

8.94e-04

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 8.94e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  88 HITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTN-YTALLILRMLQAVGGTAAIALT 166
Cdd:cd17355  241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGWGATVPLT 320

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 189203433 167 MAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAIFSG 222
Cdd:cd17355  321 AALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALG 376

MFS_MCT_like

cd17314

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...

56-222

9.23e-04

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 41.63 E-value: 9.23e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  56 TWIIFLVSISSLISPFGASMFLPALNVLSDVLHitPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRL-TFIICFVIYSI 134
Cdd:cd17314  208 FWILFIAIFLVLIGGFLFIANMASLVRSLQLDA--PSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLsTLSILLTILGL 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAA--IALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYL-GWR 211
Cdd:cd17314  286 GLCAFLFLLKMTPVGLVLTGSLLGFSYGglFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTpSYI 365

                        170
                 ....*....|.
gi 189203433 212 SIFWFLAIFSG 222
Cdd:cd17314  366 SAVYIYAVIVF 376

MFS_MFSD8

cd17326

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...

59-205

9.55e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 41.43 E-value: 9.55e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFL----PALNVLsdVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSG-RRLTFIICFVIYS 133
Cdd:cd17326    1 IYVMYLTMFLSSLQFSIVLtsiwPYLQKI--DPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAI 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189203433 134 IGNI-----GLALQTNYTALLILRMLQAVGGTAaIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLA 205
Cdd:cd17326   79 VGNIlyalaEYFPSNRKYVMLVARFLIGVGAGN-VAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT 154

MFS_ARN_like

cd17322

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...

96-184

9.94e-04

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 41.91 E-value: 9.94e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  96 ISITTYMIAQAIAPaFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADIST 175
Cdd:cd17322   42 INVVNNIVSAVSQP-PYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSS 120


                 ....*....
gi 189203433 176 SAERGTYMG 184
Cdd:cd17322  121 LKNRGFASA 129

PRK03893

putative sialic acid transporter; Provisional

79-214

1.03e-03

putative sialic acid transporter; Provisional

Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.61 E-value: 1.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  79 ALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLqavg 158
Cdd:PRK03893  42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLV---- 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 189203433 159 gtaaIALTMAvvADISTSAergTYM---------GYAQAGILMGPAFGPAIGGLLAQYL----GWRSIF 214
Cdd:PRK03893 118 ----IGMGMA--GEYGSSA---TYVieswpkhlrNKASGFLISGFSIGAVVAAQVYSLVvpvwGWRALF 177

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

46-235

1.20e-03

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.13 E-value: 1.20e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  46 PYSVFSKGMK--TWIIFLVSISSLISPFGASMFLPalNVLSDVLHITpsqvNISITTYMIAQAIApAFLGT-----LSDN 118
Cdd:cd17371  199 LRELFSPPLLrtTLLASLLATGALGGYYGITTWLP--SYLTGERGLS----FEGSAGYLVVTILG-GFLGYlaggfLADR 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 119 SGRRLTFIICFVIysiGNIGLALQT----NYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGP 194
Cdd:cd17371  272 IGRRNNFALFALG---SAISILLYFflplSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIG 348

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 189203433 195 AFGPAIGGLLAQYLGWRSIFWFLAIFSGVLLVLFVFLFPET 235
Cdd:cd17371  349 ALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389

MFS_CitA

cd17368

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...

112-216

1.48e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 41.21 E-value: 1.48e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 112 LGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTA--------LLILRMLQAVGGTAAIALTMAVVADISTSAERGTYM 183
Cdd:cd17368   60 LGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYT 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 189203433 184 GYAQAGILMGPAFGPAIGGLLAQYL--------GWRSIFWF 216
Cdd:cd17368  140 SWQSASQQVAIVAGALVGYLLSLTLtaealaewGWRIPFFI 180

MFS_SLC18A1_2_VAT1_2

cd17384

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...

35-221

1.74e-03

Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 40.63 E-value: 1.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  35 QPGLQRTLSEPpYSVFSKGMKTWIIFLVSISSLISPFGASMFLPALNV-LSDVLHITPSQVNISITTYMIAQAIAPAFLG 113
Cdd:cd17384  173 QPSVKSEESEE-GTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIwMMETMCPPKWQLGTAFLPDSIGYLIGTNLFG 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 114 TLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLI--LRMLQAVGGT-AAIALTMAVVADISTSAERGTYMGYAQAGI 190
Cdd:cd17384  252 PLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIphFGLGLGIGMVdSSMMPLLAYLVDLRHSSVYGSVYAIADVAF 331

                        170       180       190
                 ....*....|....*....|....*....|.
gi 189203433 191 LMGPAFGPAIGGLLAQYLGWRSIFWFLAIFS 221
Cdd:cd17384  332 CLAFALGPSLGGAIVKSIGFPWLMRIIGIIN 362

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

58-220

1.83e-03

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.83e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  58 IIFLVSISSLISPFGASM--FLPalnVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIySIG 135
Cdd:cd17478  197 LLLLLIIVFLRSWVLSSLttFLP---FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLL-AAP 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 136 NIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADIstsaeRGTYMGYAqAGILMGPAFG-----PAIGGLLAQYLGW 210
Cdd:cd17478  273 FLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQEL-----LPGNVGLA-SGLMMGLSFGlggigAPVLGALADAFGL 346

                        170
                 ....*....|
gi 189203433 211 RSIFWFLAIF 220
Cdd:cd17478  347 ESVLLILALL 356

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

65-221

1.89e-03

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  65 SSLISPFGASMFLPALNVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTN 144
Cdd:cd17477    4 SVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189203433 145 YTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYlGWRsIFWFLAIFS 221
Cdd:cd17477   84 PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GAL-PFLIAAVLL 158

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

91-210

1.99e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.70 E-value: 1.99e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  91 PSQVNISITTYMIA--QAIAPAFLGTLSDNSGRRLTFIICFVIYSIGN-IGLALQTNYTALLILRMLQAVGGTAAIALTM 167
Cdd:cd17356   42 PSSSRQGLIVSIVNlgSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAiIQVAAIGKWYQLIVGRIIAGLGVGFASVLVP 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 189203433 168 AVVADISTSAERGTYMGYAQAGIlmgpafgpAIGGLLAQYLGW 210
Cdd:cd17356  122 VYQSEVAPKHIRGTLVSLYQLAI--------TIGILVAYCINY 156

MFS_SV2A

cd17439

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...

110-243

2.41e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 40.40 E-value: 2.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 110 AFL-GTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQA 188
Cdd:cd17439   51 AFLwGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCM 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189203433 189 GILMGPAFGPAIGGLLAQYLGWR------------SIFWFLAIFSGVLLVLFVFLFPETCRKVVGNG 243
Cdd:cd17439  131 FWMIGGIYASAMAWAIIPHYGWSfqmgsayqfhswRVFVLVCAFPSVFAIGALTTMPESPRFFLENG 197

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

101-219

2.55e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 2.55e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 101 YMIAQAIApaflGTLSDNSGRRLTFIICFVIYSIGNI--GLALQTNYTALLILRMLQAVG-GTAAIALTMAVVADISTSa 177
Cdd:cd17380   47 YALTQVLG----GYLADRFGGKKVLLLAVALWSLATLltPLLAYSSLPLLILSRILLGLGeGVHFPSMTSLFSRWVPVS- 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 189203433 178 ERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRSIFWFLAI 219
Cdd:cd17380  122 ERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

55-220

3.99e-03

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.48 E-value: 3.99e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  55 KTWIIFLVSISSLISPFGASMFLPALnvLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSD---NSGRRLTFIICFVI 131
Cdd:cd17319  180 QVWGLALGYFGINYALYGLLTWLPTY--LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 132 YSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGP-AIGGLLAQYLGW 210
Cdd:cd17319  258 AAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPlLIGYLVDATGSY 337

                        170
                 ....*....|
gi 189203433 211 RSIFWFLAIF 220
Cdd:cd17319  338 TAAFLFLAAV 347

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

56-221

4.10e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 4.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  56 TWIIFLVsisslispFGASMFLPALN--VLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYS 133
Cdd:cd17333    1 LYISFFS--------NGLTDALLGILgpSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLIS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 134 IGNIGLALQTNYTALLILRMLQAVGGTA--AIALTMAVVADISTSAERgtyMGYAQAGILMGPAFGPAIGG-LLAQYLGW 210
Cdd:cd17333   73 LALALIFATPSIYLFVVLMFLAGLGAGIldTGANTFVGALFEESSATR---LNVLHGFFGLGALIGPLIATsLLTSELSW 149

                        170
                 ....*....|.
gi 189203433 211 RSIFWFLAIFS 221
Cdd:cd17333  150 SWAYLIIGLIY 160

synapt_SV2

TIGR01299

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...

111-210

4.21e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.

Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 4.21e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  111 FLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGI 190
Cdd:TIGR01299 221 FWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFW 300

                          90       100
                  ....*....|....*....|
gi 189203433  191 LMGPAFGPAIGGLLAQYLGW 210
Cdd:TIGR01299 301 MIGGIYAAAMAWAIIPHYGW 320

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

71-204

4.57e-03

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 4.57e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  71 FGASMFLPALnVLSDVLHITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLAL---QTNYTA 147
Cdd:cd17321  184 LGGLLFLLPL-YLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWL 262

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189203433 148 LLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLL 204
Cdd:cd17321  263 LLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319

MFS_SLC22A31

cd17443

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...

100-162

4.77e-03

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341001 [Multi-domain] Cd Length: 343 Bit Score: 39.37 E-value: 4.77e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 100 TYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQavGGTAA 162
Cdd:cd17443   44 SYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQ--GGTLA 104

MFS_NIMT_CynX_like

cd17339

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...

107-219

4.96e-03

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 4.96e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 107 IAPAFLGTLSDnsgRRLTFIICFVIYSIGNIGLALQTNyTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYM-GY 185
Cdd:cd17339  250 LVPILATRLKN---QRPIVVLLAVLFIIGVLGLLFAPT-ALALLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALsGM 325

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 189203433 186 AQAGILMGPAFGPAIGGLLAQYLG-WRSIFWFLAI 219
Cdd:cd17339  326 AQSVGYLLAALGPLLFGVLHDLTGsWTAPLVLLLA 360

MFS_SVOP_like

cd17372

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...

74-221

4.97e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.44 E-value: 4.97e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  74 SMFLPALNVLSDVLH----ITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALL 149
Cdd:cd17372   12 AMEMMLLSFVGPAVQcewnLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLI 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189203433 150 ILRMLqaVG-GTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGWRsifWFLAIFS 221
Cdd:cd17372   92 ILRCL--VGlGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWR---WLLAFSS 159

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

56-219

7.79e-03

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.72 E-value: 7.79e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  56 TWIIFLVSISSLISPFGASMFLPALNVLSDvlhITPSQVNISITTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIG 135
Cdd:cd17365  173 TLLLWVTFFMGLLLVYLLNSWLPKLMVEAG---YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVS 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 136 NIGLALQTNYTALL-ILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGG-LLAQYLGWRSI 213
Cdd:cd17365  250 LALLGVSPASLVLLyVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGlLLAAGLGPESV 329


                 ....*.
gi 189203433 214 FWFLAI 219
Cdd:cd17365  330 FLALAI 335

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

59-219

8.75e-03

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 8.75e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  59 IFLVSISSLISPFGASMFLPALNVLSDVLHITPSQVNIsITTymIAQAIAPA---FLGTLSDNSGRRLTFIIC-FVIYSI 134
Cdd:cd17370    1 VWLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGL-IEG--LAEALGSLlrlFSGYLSDRTGKRKPLVILgYGLSAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 135 GNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGTYMGYAQAGILMGPAFGPAIGGLLAQYLGW--RS 212
Cdd:cd17370   78 AKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyRT 157


                 ....*..
gi 189203433 213 IFWFLAI 219
Cdd:cd17370  158 IFLLAAI 164

MFS_SLC22A6_OAT1_like

cd17446

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...

99-185

9.14e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.55 E-value: 9.14e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433  99 TTYMIAQAIAPAFLGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVAD---IST 175
Cdd:cd17446   40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEwmpTRV 119

                         90
                 ....*....|
gi 189203433 176 SAERGTYMGY 185
Cdd:cd17446  120 RAVVGTLLGY 129

MFS_SLC22A1_2_3

cd17379

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...

112-181

9.84e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.49 E-value: 9.84e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189203433 112 LGTLSDNSGRRLTFIICFVIYSIGNIGLALQTNYTALLILRMLQAVGGTAAIALTMAVVADISTSAERGT 181
Cdd:cd17379   53 IGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRT 122

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01