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Conserved domains on  [gi|299755778|ref|XP_001828881|]
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WD40 repeat-containing protein [Coprinopsis cinerea okayama7#130]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-322 6.56e-99

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 297.21  E-value: 6.56e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQV 285
Cdd:COG2319  291 VNS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AF---SPDGKTLASGSDDGTVRLWDLATGEL 364

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 299755778 286 LQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADG--TVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-322 6.56e-99

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 297.21  E-value: 6.56e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQV 285
Cdd:COG2319  291 VNS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AF---SPDGKTLASGSDDGTVRLWDLATGEL 364

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 299755778 286 LQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADG--TVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-322 1.12e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 267.28  E-value: 1.12e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:cd00200   20 DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:cd00200  100 AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQV 285
Cdd:cd00200  180 VNS-VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV--AF---SPDGYLLASGSEDGTIRVWDLRTGEC 253

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 299755778 286 LQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:cd00200  254 VQTLSGHTNSVTSLAWSPDGKRLASGSADG--TIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 46-278 9.09e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 9.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESgdIIHTFR---------GHKEGINDLAW-APDGEFIASASDDKTVIIWSLELREPVKTL 115
Cdd:PLN00181 494 DGEFFATAGVNKKIKIFECES--IIKDGRdihypvvelASRSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 116 SRHTSVVFCINY-NPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDpVTAVGF-NDDGTLIISCAMDGLIRLWDAESG 193
Cdd:PLN00181 572 KEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpSESGRSLAFGSADHKVYYYDLRNP 650

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 194 QC-LKTLVDDDNPIcSHVCFSPNSKFALASTqDSTIRLWNIQSSRC------VKTYTGHVNRTYcipacFATKSSKGQYI 266
Cdd:PLN00181 651 KLpLCTMIGHSKTV-SYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN-----FVGLSVSDGYI 723

                        250
                 ....*....|..
gi 299755778 267 VTGSEDGKIYVW 278
Cdd:PLN00181 724 ATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-105 5.28e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 5.28e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 299755778    66 SGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWS 105
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
67-105 2.93e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 2.93e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 299755778   67 GDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWS 105
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-322 6.56e-99

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 297.21  E-value: 6.56e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQV 285
Cdd:COG2319  291 VNS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AF---SPDGKTLASGSDDGTVRLWDLATGEL 364

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 299755778 286 LQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADG--TVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
46-322 4.32e-92

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 279.87  E-value: 4.32e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQV 285
Cdd:COG2319  249 VRS-VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AF---SPDGKLLASGSDDGTVRLWDLATGKL 322

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 299755778 286 LQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDG--TVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-322 1.12e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 267.28  E-value: 1.12e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:cd00200   20 DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:cd00200  100 AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQV 285
Cdd:cd00200  180 VNS-VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV--AF---SPDGYLLASGSEDGTIRVWDLRTGEC 253

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 299755778 286 LQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:cd00200  254 VQTLSGHTNSVTSLAWSPDGKRLASGSADG--TIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
46-282 7.61e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 253.68  E-value: 7.61e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQS 282
Cdd:COG2319  333 VRS-VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV--AF---SPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
45-322 3.02e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 244.44  E-value: 3.02e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  45 TDGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFC 124
Cdd:COG2319   46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 125 INYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDN 204
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 205 PICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQ 284
Cdd:COG2319  206 AVRS-VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AF---SPDGRLLASGSADGTVRLWDLATGE 279

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 299755778 285 VLQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDG--TVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-279 1.51e-74

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 231.07  E-value: 1.51e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:cd00200   62 DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:cd00200  142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 299755778 206 ICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWD 279
Cdd:cd00200  222 VNS-VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL--AW---SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-322 2.63e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.92  E-value: 2.63e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCI 125
Cdd:COG2319    5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 126 NYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNP 205
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 206 IcSHVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQV 285
Cdd:COG2319  165 V-TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AF---SPDGKLLASGSADGTVRLWDLATGKL 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 299755778 286 LQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPDGRLLASGSADG--TVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
84-322 5.16e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.16  E-value: 5.16e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  84 AWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCINYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDP 163
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 164 VTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNPICShVCFSPNSKFALASTQDSTIRLWNIQSSRCVKTYT 243
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 299755778 244 GHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWDLQSRQVLQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:COG2319  160 GHSGAVTSV--AF---SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG--TVRLW 231
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 46-278 9.09e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 9.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESgdIIHTFR---------GHKEGINDLAW-APDGEFIASASDDKTVIIWSLELREPVKTL 115
Cdd:PLN00181 494 DGEFFATAGVNKKIKIFECES--IIKDGRdihypvvelASRSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 116 SRHTSVVFCINY-NPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDpVTAVGF-NDDGTLIISCAMDGLIRLWDAESG 193
Cdd:PLN00181 572 KEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpSESGRSLAFGSADHKVYYYDLRNP 650

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 194 QC-LKTLVDDDNPIcSHVCFSPNSKFALASTqDSTIRLWNIQSSRC------VKTYTGHVNRTYcipacFATKSSKGQYI 266
Cdd:PLN00181 651 KLpLCTMIGHSKTV-SYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN-----FVGLSVSDGYI 723

                        250
                 ....*....|..
gi 299755778 267 VTGSEDGKIYVW 278
Cdd:PLN00181 724 ATGSETNEVFVY 735
PTZ00421 PTZ00421
coronin; Provisional
 75-193 7.12e-12

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 66.07  E-value: 7.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  75 GHKEGINDLAWAP-DGEFIASASDDKTVIIWSL-------ELREPVKTLSRHTSVVFCINYNPNS-NLLVSGGYDETVII 145
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 299755778 146 WDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESG 193
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-105 5.28e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 5.28e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 299755778    66 SGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWS 105
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 63-322 1.65e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  63 DTESGDIIHTfrghKEGINDLAWAPDGEFIASASDDKTVIIWSLE--------LREPVKTL-SRHTSVVFCINYNPNSNL 133
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFECEsiikdgrdIHYPVVELaSRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 134 lVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFND-DGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNpICshvcf 212
Cdd:PLN00181 549 -ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-IC----- 621

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 213 spnskfalastqdstirlwniqssrcvktytghvnrtycipaCFATKSSKGQYIVTGSEDGKIYVWDLQSRQV-LQVIEG 291
Cdd:PLN00181 622 ------------------------------------------CVQFPSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIG 659

                        250       260       270
                 ....*....|....*....|....*....|.
gi 299755778 292 HRDVVLAMATHPTRNIIASASmdkDMTIKFW 322
Cdd:PLN00181 660 HSKTVSYVRFVDSSTLVSSST---DNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
67-105 2.93e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 2.93e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 299755778   67 GDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWS 105
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
151-189 1.72e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 1.72e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 299755778  151 GKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWD 189
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-189 1.87e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 1.87e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 299755778   151 GKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWD 189
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 109-147 3.76e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 3.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 299755778   109 REPVKTLSRHTSVVFCINYNPNSNLLVSGGYDETVIIWD 147
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 62-152 5.64e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.19  E-value: 5.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  62 WDTESGDIIHTFR--------------GHKEGINDLAWAP-DGEFIASASDDKTVIIWSL--------ELREPVKTLSRH 118
Cdd:PTZ00420  45 WEVEGGGLIGAIRlenqmrkppviklkGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGH 124

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 299755778 119 TSVVFCINYNP-NSNLLVSGGYDETVIIWDVARGK 152
Cdd:PTZ00420 125 KKKISIIDWNPmNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
109-147 4.20e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 299755778  109 REPVKTLSRHTSVVFCINYNPNSNLLVSGGYDETVIIWD 147
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 49-186 1.03e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  49 MLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTS-----VVF 123
Cdd:PTZ00421 140 VLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrCLW 219

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 299755778 124 CINYNPNSNLLVSGGYDETVIIWDVAR-GKALKTLPAHSDPVTAVGFNDDGT--LIISCAMDGLIR 186
Cdd:PTZ00421 220 AKRKDLIITLGCSKSQQRQIMLWDTRKmASPYSTVDLDQSSALFIPFFDEDTnlLYIGSKGEGNIR 285
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 112-309 1.72e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.91  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  112 VKTLSRHTSVVFCINYNPNSNLLVSGGYDETVIIWDVARGKALK-----------------------TLPAHSDPVTAVG 168
Cdd:pfam20426 117 VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIITCLY 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  169 FNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNPICSHVCFSPNSKFALASTQDSTIRLWNIQ-----SSRCvktyT 243
Cdd:pfam20426 197 VSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHLYSINgkhiaSSES----N 272

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 299755778  244 GHVNrtyCIPAcfatkSSKGQYIVTGSEDGKIYVWDLQSRQVLQVIEGHRDVVLAMATHPTRNIIA 309
Cdd:pfam20426 273 GRLN---CIEL-----SSCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLA 330
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 83-172 9.41e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 9.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778   83 LAWAPDGEFIASASDDKTVI--------IWSLELREpvktlsrHTSVVFCINYNPNSNLLVSGGYDETVIIWDVARGKAL 154
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLlhrlnwqrVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73

                          90
                  ....*....|....*...
gi 299755778  155 KTLPAHSDPVTAVGFNDD 172
Cdd:pfam12894  74 HHFSAGSDLITCLGWGEN 91
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
130-283 1.02e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 130 NSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDGTLIISCAMDGLIRLWDAESGQCLKTLVDDDNPicSH 209
Cdd:COG3391   79 GRRLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP--HG 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 210 VCFSPNSKFALASTQDST-----IRLWNIQSSRCVKTYTGHVNrtyciPACFATkSSKGQYIV--------TGSEDGKIY 276
Cdd:COG3391  157 IAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVGGG-----PVGVAV-SPDGRRLYvanrgsntSNGGSNTVS 230


                 ....*..
gi 299755778 277 VWDLQSR 283
Cdd:COG3391  231 VIDLATL 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-279 1.61e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.61e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 299755778   235 SSRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWD 279
Cdd:smart00320   1 SGELLKTLKGHTGPVTSV--AF---SPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 282-322 4.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.13e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 299755778   282 SRQVLQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDG--TIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 46-86 5.26e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 5.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 299755778   46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDLAWA 86
Cdd:pfam12894  49 DGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 46-286 7.91e-05

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 43.76  E-value: 7.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  46 DGSMLASAGPDKTIKLWDTESGDIIHTFRGHKEGINDlawAPDGEFIASASDDKTVI---------IWSL---ELREPVK 113
Cdd:cd22857   43 SEPLLAVARKNGTVEVLDPENGDLLASFSDSEPATKL---SEEDHFVGLHLFSGTLLtctskgslrSTKLpddSTASSSP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 114 TLSRHTSV-VFCINYNPNSNLLVSGGYDETVIIWDVaRGKALKTLPAHSDP-----------VTAVGF--NDDGTLIISC 179
Cdd:cd22857  120 TAWVCLGGnLLCMRVDPNENYFAFGGKEVELNVWDL-EEKPGKIWRAKNVPndslglrvpvwVTDLTFlsKDDHRKIVTG 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 180 AMDGLIRLWDAESGQCLKTLVD-DDNPICShVCFSPNSKFALAStqDSTIRLWNIqSSRcvktyTGHVNRtycipaCFAT 258
Cdd:cd22857  199 TGYHQVRLYDTRAQRRPVVSVDfGETPIKA-VAEDPDGHTVYVG--DTSGDLASI-DLR-----TGKLLG------CFKG 263

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 299755778 259 KSSK----------GQYIVTGSEDGKIYVWDLQSRQVL 286
Cdd:cd22857  264 KCGGsirsiarhpeLPLIASCGLDRYLRIWDTETRQLL 301
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 75-130 8.74e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 8.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 299755778   75 GHKEGINDLAWAPDGEFIASASDDKTVIIWSLELREPVKTLSRHTSVVFCINYNPN 130
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
236-279 1.70e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 299755778  236 SRCVKTYTGHVNRTYCIpaCFatkSSKGQYIVTGSEDGKIYVWD 279
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSL--AF---SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-232 2.07e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 299755778   192 SGQCLKTLVDDDNPICShVCFSPNSKFALASTQDSTIRLWN 232
Cdd:smart00320   1 SGELLKTLKGHTGPVTS-VAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
111-290 2.10e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 111 PVKTLSRHTSVVFCINYNPNSNLLVSGGYDETVIIWDVARGKALKTLPAHSDPVTAVGFNDDG-TLIISCAMDGLIRLWD 189
Cdd:COG3391   17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrRLYVANSGSGRVSVID 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778 190 AESGQCLKTLVDDDNPicSHVCFSPNSKFAL-ASTQDSTIRLWNIQSSRCVKTYTGHVNrtyciPACFATKSSKGQYIVT 268
Cdd:COG3391   97 LATGKVVATIPVGGGP--RGLAVDPDGGRLYvADSGNGRVSVIDTATGKVVATIPVGAG-----PHGIAVDPDGKRLYVA 169

                        170       180
                 ....*....|....*....|....*.
gi 299755778 269 GSEDGKI----YVWDLQSRQVLQVIE 290
Cdd:COG3391  170 NSGSNTVsvivSVIDTATGKVVATIP 195
WD40 pfam00400
WD domain, G-beta repeat;
283-322 3.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 299755778  283 RQVLQVIEGHRDVVLAMATHPTRNIIASASMDKdmTIKFW 322
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDG--TVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
193-232 3.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 299755778  193 GQCLKTLVDDDNPICShVCFSPNSKFALASTQDSTIRLWN 232
Cdd:pfam00400   1 GKLLKTLEGHTGSVTS-LAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 49-107 6.85e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 6.85e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 299755778  49 MLASAGPDKTIKLWD--------TESGDIIHTFRGHKEGINDLAWAPDGEFIASASD-DKTVIIWSLE 107
Cdd:PTZ00420  89 ILASGSEDLTIRVWEiphndesvKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDIE 156
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 127-202 3.19e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.72  E-value: 3.19e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 299755778 127 YNPNSNLLVSGGYDETVIIWDVArGKALKTLPAHSDPVTAVGFNDDGTLIIsCAMDGLIRLWDAESGQcLKTLVDD 202
Cdd:COG3386   15 WDPDGRLYWVDIPGGRIHRYDPD-GGAVEVFAEPSGRPNGLAFDPDGRLLV-ADHGRGLVRFDPADGE-VTVLADE 87
PTZ00421 PTZ00421
coronin; Provisional
 264-322 4.28e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.72  E-value: 4.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 299755778 264 QYIVTGSEDGKIYVWDLQSRQVLQVI-------EGHRDVVLAMATHPT-RNIIASASMdkDMTIKFW 322
Cdd:PTZ00421  89 QKLFTASEDGTIMGWGIPEEGLTQNIsdpivhlQGHTKKVGIVSFHPSaMNVLASAGA--DMVVNVW 153
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 127-209 5.15e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299755778  127 YNPNSNLLVSGGYDETVI--------IWDVArgkalktLPAHSDPVTAVGFNDDGTLI-ISCAmDGLIRLWDAESGQCLK 197
Cdd:pfam12894   3 WCPTMDLIALATEDGELLlhrlnwqrVWTLS-------PDKEDLEVTSLAWRPDGKLLaVGYS-DGTVRLLDAENGKIVH 74

                          90
                  ....*....|...
gi 299755778  198 TL-VDDDNPICSH 209
Cdd:pfam12894  75 HFsAGSDLITCLG 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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