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Conserved domains on  [gi|169785487|ref|XP_001827204|]
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unnamed protein product [Aspergillus oryzae RIB40]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 43-471 1.33e-94

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 291.02  E-value: 1.33e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  43 IAVISVYGLISPVIAAIIVPAMPQIATDLNVTDPGMLqAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNA 122
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 123 LCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWC 202
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 203 SLYILITWVVGLCTLretfrpvliqrkqaaavrkgqlpgsvqhhhksladvfrqdlrrpftflgtqPIIQVLSLFMGYLF 282
Cdd:cd17323  160 AIISGFCLILIFLFL---------------------------------------------------PIVLLLGLYVGLVY 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 283 GLNHLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIYIYYTSKDPAKGTPELRTILMLPAALLVPT 362
Cdd:cd17323  189 AILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPI 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 363 GLLIYGWSAQTHSHWIMPNIGIGIYALGLIMSYQCIQAYVLDCYAVYAASAMGALTILRSLLGFVLPILAPLIYRTLGYG 442
Cdd:cd17323  269 GLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVG 348

                        410       420
                 ....*....|....*....|....*....
gi 169785487 443 WGSSLLALWALVMgGLVPILLWRYGAVLR 471
Cdd:cd17323  349 WAFTLLAFISLAM-IPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 43-471 1.33e-94

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 291.02  E-value: 1.33e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  43 IAVISVYGLISPVIAAIIVPAMPQIATDLNVTDPGMLqAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNA 122
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 123 LCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWC 202
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 203 SLYILITWVVGLCTLretfrpvliqrkqaaavrkgqlpgsvqhhhksladvfrqdlrrpftflgtqPIIQVLSLFMGYLF 282
Cdd:cd17323  160 AIISGFCLILIFLFL---------------------------------------------------PIVLLLGLYVGLVY 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 283 GLNHLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIYIYYTSKDPAKGTPELRTILMLPAALLVPT 362
Cdd:cd17323  189 AILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPI 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 363 GLLIYGWSAQTHSHWIMPNIGIGIYALGLIMSYQCIQAYVLDCYAVYAASAMGALTILRSLLGFVLPILAPLIYRTLGYG 442
Cdd:cd17323  269 GLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVG 348

                        410       420
                 ....*....|....*....|....*....
gi 169785487 443 WGSSLLALWALVMgGLVPILLWRYGAVLR 471
Cdd:cd17323  349 WAFTLLAFISLAM-IPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-425 4.87e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 119.69  E-value: 4.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  37 SYRWLCIAVISVYGLISPVIAAIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGL 116
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 117 FLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWR 196
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 197 AIFAWCSLYILITWVVGLCTLRETfrpvliqrkqaaavrkgqLPGSVQHHHKSLADVFRqdlrrpftflgtQPIIQVLSL 276
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRLLPES------------------RPAARARLRGSLRELLR------------RPRLLLLLL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 277 FMGYLFGLNHLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIYiyytskdpakgtpelRTILMLPA 356
Cdd:COG2814  215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG---------------RRRLLLIG 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 357 ALLVPTGLLIYGWSaqthSHWIMPNIGIGIYALGLIMSYQCIQAYVLDCY-AVYAASAMGALTILRSLLG 425
Cdd:COG2814  280 LLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
46-429 1.41e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.87  E-value: 1.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   46 ISVYGLISPVIAAIIVPAMPQIATDLNVTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCA 125
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  126 FARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLY 205
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  206 ILITWVVGLCTLRETFRPVLIQRKQAaavrkgqlpgsvqhhHKSLADVFRQDLRRPFTFLgtqpiiqvlsLFMGYLFGLN 285
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEA---------------RLSLIVAWKALLRDPVLWL----------LLALLLFGFA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  286 HLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIyiyytskdpakgTPELRTILMLPAALLVPTGLL 365
Cdd:pfam07690 216 FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL------------GRRRRLLLALLLLILAALGLL 283

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169785487  366 IYGWSAQTHSHWIMpnigIGIYALGLIMSYQCIQAYVLDCYAV-YAASAMGALTILRSLLGFVLP 429
Cdd:pfam07690 284 LLSLTLSSLWLLLA----LLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 51-204 4.09e-18

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 85.90  E-value: 4.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   51 LISPVIAAIIVPAMPQIATDLNvTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSD 130
Cdd:TIGR00710  15 ILGPLGIDMYLPAFPEIAADLS-TPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNI 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 169785487  131 YELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSL 204
Cdd:TIGR00710  94 ETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
61-223 7.36e-18

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 84.97  E-value: 7.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  61 VPAMPQIATDLNVtDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFIT 140
Cdd:PRK11102  11 LPALPVIAADFGV-SAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 141 GAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRET 220
Cdd:PRK11102  90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169


                 ...
gi 169785487 221 FRP 223
Cdd:PRK11102 170 LPK 172
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 43-471 1.33e-94

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 291.02  E-value: 1.33e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  43 IAVISVYGLISPVIAAIIVPAMPQIATDLNVTDPGMLqAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNA 122
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 123 LCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWC 202
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 203 SLYILITWVVGLCTLretfrpvliqrkqaaavrkgqlpgsvqhhhksladvfrqdlrrpftflgtqPIIQVLSLFMGYLF 282
Cdd:cd17323  160 AIISGFCLILIFLFL---------------------------------------------------PIVLLLGLYVGLVY 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 283 GLNHLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIYIYYTSKDPAKGTPELRTILMLPAALLVPT 362
Cdd:cd17323  189 AILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPI 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 363 GLLIYGWSAQTHSHWIMPNIGIGIYALGLIMSYQCIQAYVLDCYAVYAASAMGALTILRSLLGFVLPILAPLIYRTLGYG 442
Cdd:cd17323  269 GLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVG 348

                        410       420
                 ....*....|....*....|....*....
gi 169785487 443 WGSSLLALWALVMgGLVPILLWRYGAVLR 471
Cdd:cd17323  349 WAFTLLAFISLAM-IPIPFIFYKYGKKIR 376
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 43-464 3.82e-31

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 123.45  E-value: 3.82e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  43 IAVISVYGLISPVIAAIIVPAMPQIATDLNVtDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNA 122
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGA-SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 123 LCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWC 202
Cdd:cd17320   80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 203 SLYILITWVVGLCTLRETFRPvlIQRKQAAavrkgqlpgsvqhhhKSLADVFRQDLRRPFtflgtqpiiqvlslFMGYLF 282
Cdd:cd17320  160 ALLGLLLLLLVLLFLPETLPE--EKRKPLL---------------SSLLRAYKRVLKNRR--------------FLGYAL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 283 --GLNHLSITTFESVWTDIYNQ----TPSRAALNYISIAGGFILGSQITGSLNDRIyiyytskdpakgTPELRTILMLPA 356
Cdd:cd17320  209 alGLSFAGLFAYLAAAPFIYIEqlglSPAQFGLLFALNAIALILGSLLNGRLVRRF------------GPRRLLRLGLLL 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 357 ALLVPTGLLIYGWSAQTHSHWIMpnIGIGIYALGLIMSYQCIQAYVLDCYAVYAASAMGALTILRSLLGFVLPILAPLIY 436
Cdd:cd17320  277 LLAAALVLLLAALLGGLSLWPLV--APLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLP 354

                        410       420
                 ....*....|....*....|....*...
gi 169785487 437 RTlgygwGSSLLALWALVMGGLVPILLW 464
Cdd:cd17320  355 NG-----TALPMGLLILVLGLLALLLLI 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-425 4.87e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 119.69  E-value: 4.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  37 SYRWLCIAVISVYGLISPVIAAIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGL 116
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 117 FLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWR 196
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 197 AIFAWCSLYILITWVVGLCTLRETfrpvliqrkqaaavrkgqLPGSVQHHHKSLADVFRqdlrrpftflgtQPIIQVLSL 276
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRLLPES------------------RPAARARLRGSLRELLR------------RPRLLLLLL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 277 FMGYLFGLNHLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIYiyytskdpakgtpelRTILMLPA 356
Cdd:COG2814  215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG---------------RRRLLLIG 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 357 ALLVPTGLLIYGWSaqthSHWIMPNIGIGIYALGLIMSYQCIQAYVLDCY-AVYAASAMGALTILRSLLG 425
Cdd:COG2814  280 LLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
46-429 1.41e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.87  E-value: 1.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   46 ISVYGLISPVIAAIIVPAMPQIATDLNVTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCA 125
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  126 FARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLY 205
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  206 ILITWVVGLCTLRETFRPVLIQRKQAaavrkgqlpgsvqhhHKSLADVFRQDLRRPFTFLgtqpiiqvlsLFMGYLFGLN 285
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEA---------------RLSLIVAWKALLRDPVLWL----------LLALLLFGFA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  286 HLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIyiyytskdpakgTPELRTILMLPAALLVPTGLL 365
Cdd:pfam07690 216 FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL------------GRRRRLLLALLLLILAALGLL 283

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169785487  366 IYGWSAQTHSHWIMpnigIGIYALGLIMSYQCIQAYVLDCYAV-YAASAMGALTILRSLLGFVLP 429
Cdd:pfam07690 284 LLSLTLSSLWLLLA----LLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 39-235 3.25e-19

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 87.94  E-value: 3.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  39 RWLCIAVISVYGLISPVIAAIIVPAMPQIATDLNvTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFL 118
Cdd:COG0477   12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLG-ASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 119 VFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAI 198
Cdd:COG0477   91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 169785487 199 FaWCSLYILITWVVGLCTLRETFRPVLIQRKQAAAVR 235
Cdd:COG0477  171 F-LINAPLGLLALVLRLRLPESRGLLLALLALALAAL 206
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 59-465 1.05e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 87.63  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRF 138
Cdd:cd17325   14 IIIPILPLYAESLGAS-VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 139 ITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLR 218
Cdd:cd17325   93 LQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 219 ETFRPVLIQRKQAAavrkgqlpgsvqhhhksladvfrqDLRRPFTFLGTQPIIQVLSLFmgylFGLNHLSITTFESV--- 295
Cdd:cd17325  173 EPRPPPNKRAVSAA------------------------RLRSGLRLLLRDRRLLALFLA----IFVLAFAFGALEPFlpl 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 296 -WTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIyiyytskdpakgtpeLRTILMLPAALLVPTGLLIYgwsAQTH 374
Cdd:cd17325  225 yAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI---------------GRKPLILIGLLLSAVALLLL---PLAT 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 375 SHWIMPnIGIGIYALGLIMSYQCIQAYVLDCYAVYA-ASAMGALTILRSLLGFVLPILAPLIYRTLGYGWGSSLLALWAL 453
Cdd:cd17325  287 SFWLLL-LLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLL 365

                        410
                 ....*....|..
gi 169785487 454 VmgGLVPILLWR 465
Cdd:cd17325  366 L--AAVLFLLLR 375
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 51-459 1.63e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 86.86  E-value: 1.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  51 LISPVIAAIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSD 130
Cdd:cd17474    9 LLAVLGVSIVDPILPAIAEALGAS-PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 131 YELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHtSWRAIFAWCSLYILITW 210
Cdd:cd17474   88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 211 VVGLCTLRETFRPVLIQRKQAaavrkgqlpgsvqhhhksladvfrqdLRRPFTFLGTQPIIQVLSLFMGYLFGLNHLsIT 290
Cdd:cd17474  167 LAILFLLPEPKEKAKSSSATK--------------------------LRDLKKALRGRGLLTFLVSAFLYFFLYFAF-LT 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 291 TFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRiyiyytskdpakgtpELRTILMLPAALLVPTGLLIygWS 370
Cdd:cd17474  220 YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK---------------RFGARRILVIGLLLYALSLL--LL 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 371 AQTHSHWIMPnIGIGIYALGLIMSYQCIQAYVLDCY-AVYAASAMGALTILRSLLGFVLPILAPLIYRTLGYGWGSSLLA 449
Cdd:cd17474  283 GFVPSLALLL-IAIVLFGLGLGLNLPLLTTLVTELApEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGA 361

                        410
                 ....*....|
gi 169785487 450 LWALVMGGLV 459
Cdd:cd17474  362 AIALAAAVLL 371
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 59-332 2.86e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 86.06  E-value: 2.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNVTDPGMLQAfVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRF 138
Cdd:cd17324   17 VIQGLLPDIARDFGVSVAQAGLL-VSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 139 ITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFawcslyilitWVVGLCTLr 218
Cdd:cd17324   96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF----------LAIAVLAL- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 219 etfrpvLIqrkqAAAVRKGqLPGSVQHHHKSLadvfrqDLRRPFTFLGTQPIIQVLSLFMGYLFGLNHLSITTFESVWTD 298
Cdd:cd17324  165 ------LA----ALLLWRL-LPSLPPKKPGSL------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTD 227

                        250       260       270
                 ....*....|....*....|....*....|....
gi 169785487 299 IYNQTPSRAALNYISIAGGFILGSQITGSLNDRI 332
Cdd:cd17324  228 VPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
38-465 3.63e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 85.69  E-value: 3.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  38 YRWLCIAVISVYGLISPVIAAIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLF 117
Cdd:COG2271    7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLS-AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 118 LVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRA 197
Cdd:COG2271   86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 198 IFAWCSLYILITWVVGLCTLretfrpvliqrkqaaavrkgqlpgsvqhhhksladvfrqdlrrpftflgtqpIIQVLSLF 277
Cdd:COG2271  166 AFLILGLPGLLLALLRFWLL----------------------------------------------------ALAYFLVY 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 278 MGYLFGLNHLSittfeSVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIyiyytskdpakgtPELRTILMLPAA 357
Cdd:COG2271  194 FALYGFLTWLP-----TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL-------------GRRRKLVLAIGL 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 358 LLVPTGLLIYGWsaqTHSHWIMpNIGIGIYALGLIMSYQCIQAYVLDCY-AVYAASAMGALTILRSLLGFVLPILAPLIY 436
Cdd:COG2271  256 LLAALALLLLAL---LPSPALA-IALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLL 331

                        410       420
                 ....*....|....*....|....*....
gi 169785487 437 RTLGYGWGSSLLALWALVMGGLVPILLWR 465
Cdd:COG2271  332 DATGYQAAFLLLAALALLAALLALLLLRE 360
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 51-204 4.09e-18

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 85.90  E-value: 4.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   51 LISPVIAAIIVPAMPQIATDLNvTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSD 130
Cdd:TIGR00710  15 ILGPLGIDMYLPAFPEIAADLS-TPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNI 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 169785487  131 YELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSL 204
Cdd:TIGR00710  94 ETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
61-223 7.36e-18

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 84.97  E-value: 7.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  61 VPAMPQIATDLNVtDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFIT 140
Cdd:PRK11102  11 LPALPVIAADFGV-SAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 141 GAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRET 220
Cdd:PRK11102  90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169


                 ...
gi 169785487 221 FRP 223
Cdd:PRK11102 170 LPK 172
2_A_01_02 TIGR00880
Multidrug resistance protein;
84-220 5.55e-17

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 77.69  E-value: 5.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   84 SVYVLGWSFAPLVVGPLSEV----YGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLW 159
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169785487  160 APEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRET 220
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 51-199 3.29e-15

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 76.83  E-value: 3.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  51 LISPVIAAIIVPAMPQIATDLNvTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSD 130
Cdd:cd17321    6 FLAALDVTIVNVALPTIARDLG-ASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 169785487 131 YELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIF 199
Cdd:cd17321   85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF 153
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 63-199 2.02e-14

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 74.53  E-value: 2.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  63 AMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGA 142
Cdd:cd17503   18 ALPTIMGDLGAS-LDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 169785487 143 VGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIF 199
Cdd:cd17503   97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF 153
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
62-200 2.21e-13

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 71.46  E-value: 2.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  62 PAMPQIATDLNvTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITg 141
Cdd:PRK11043  27 PAFKAIQADLQ-TSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQ- 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169785487 142 AVG--SAPLSIGAGIIgDLWaPEERGLSIsLYTLGPL--LGPAIAPITGAYIVSHTSWRAIFA 200
Cdd:PRK11043 105 AVGvcSAAVIWQALVI-DRY-PAQKANRV-FATIMPLvaLSPALAPLLGAWLLNHFGWQAIFA 164
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 46-458 4.08e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.53  E-value: 4.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  46 ISVYGLISPVIAAIIVPAMPQIATDLNVTDpGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCA 125
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSA-SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 126 FARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSH--TSWRAIFAWCS 203
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 204 LYILITWVVGLCTLRETfrpvliqrkqaaaVRKGQLPGSVQHHHKSLADVFRQDLRRPFTFLGtqpIIQVLSLFMGYLFg 283
Cdd:cd06174  160 ALALLAAILLLLVVPDP-------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLL---LAIFLVNLAYYSF- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 284 lnhlsITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIYIyytskdpakgtpelRTILMLPAALLVPTG 363
Cdd:cd06174  223 -----STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------------RKPLLLIGLLLMALG 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 364 LLIYGWSAQTHSHWIMPNIGIGIYALGLIMSYQCIQAYVLdcyAVYAASAMGALTILRSLLGFVLPILA-PLIYRTLGYG 442
Cdd:cd06174  284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP---PEIRGTAFGLLNTFGFLGGAIGPLLAgFLLAATFGLT 360

                        410
                 ....*....|....*.
gi 169785487 443 WGSSLLALWALVMGGL 458
Cdd:cd06174  361 GAFLVLAVLLLLAAIL 376
emrD PRK11652
multidrug transporter EmrD;
59-233 5.58e-13

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 70.32  E-value: 5.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNVtDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVfNALCAFARSDYELLIlrf 138
Cdd:PRK11652  26 IYVPAIADMARDLNV-REGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFIL-GTLVALFAHSLTVLI--- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 139 itgaVGSAPLSIGAGIIG--------DLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITW 210
Cdd:PRK11652 101 ----AASAIQGLGTGVGGvmartlprDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVT 176

                        170       180
                 ....*....|....*....|...
gi 169785487 211 VVGLCTLRETfRPVLIQRKQAAA 233
Cdd:PRK11652 177 FSMARWMPET-RPADARRTRVLA 198
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 59-199 1.10e-12

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 69.13  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNvtDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRF 138
Cdd:cd17502   14 IVATALPTIVAEFG--GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRA 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169785487 139 ITGAVGSAPLSIGAGIIGDLWAPEERGLSI----SLYTLGPLLGPAIapitGAYIVSHTSWRAIF 199
Cdd:cd17502   92 IQGIGGGGLMSLAFIIIADLVPPRERGKYQgyigAVFGIASVAGPLI----GGAFTDHLSWRWCF 152
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
37-466 1.71e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 68.75  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  37 SYRWLCIAVISVYGLISPVIAAIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGL 116
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLS-AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 117 FLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWR 196
Cdd:COG2223   80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 197 AIFAWCSLYILITWVVGLCTLRETfrPVLIQRKQAAAVRkgqlpgsvqhhhkSLADVFRqdlrrpftflgtQPIIQVLSL 276
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDP--PAGAAAAAKASLR-------------DQLEALR------------DPRFWLLSL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 277 FMGYLFGLNHLSITTFESVWTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIyiyytskdpakgtPELRTILMLPA 356
Cdd:COG2223  213 LYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-------------GGRRVLLIVFA 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 357 ALLVPTGLLIYgwsaqTHSHWIMPNIGIGIYALGLIMSYQCIQAYVLDCYAV-YAASAMGALTILRSLLGFVLPILAPLI 435
Cdd:COG2223  280 LMALGLLLLAL-----ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTkNAGAVYGLVGAAGGLGGFLGPLLFGAL 354

                        410       420       430
                 ....*....|....*....|....*....|.
gi 169785487 436 YRTLGyGWGSSLLALWALVMGGLVpILLWRY 466
Cdd:COG2223  355 LDATG-SYTAAFLVFAVLALVALV-LTLLLY 383
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 39-204 6.23e-11

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 63.74  E-value: 6.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  39 RWLCIAVISVYGLISPVIAAIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFL 118
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLS-PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 119 VFNALCAFARSDYELLILRFITGaVGSAPLSIGAGIIGDLWAP-EERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRA 197
Cdd:cd17319   80 LFTALTGFATSLTSLYVLRFLLG-VAEAGFFPGAIKALAEWFPaRERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW 158


                 ....*..
gi 169785487 198 IFAWCSL 204
Cdd:cd17319  159 AFIIEGL 165
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 37-200 9.49e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.45  E-value: 9.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   37 SYRWLCIAVISVYGLISPVIAAIIVPAMPQIATDLNVtDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGL 116
Cdd:TIGR00895  13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGL-DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  117 FLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWR 196
Cdd:TIGR00895  92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171


                  ....
gi 169785487  197 AIFA 200
Cdd:TIGR00895 172 SLFY 175
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 64-332 2.16e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 59.24  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  64 MPQIATDLNVT--DPGMLqafVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITG 141
Cdd:cd17371   22 LPALIAEFGLDeaEAGLL---GTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 142 AVGSAPLSIGAGIIGDLWAPEERGLSISL----YTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLcTL 217
Cdd:cd17371   99 LGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRR-FV 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 218 REtfrPVLIQRKQAAAVRKGQLPgsvqhhhkSLADVFRQDLRRpfTFLGTqpiiqvlSLFMGYLFGLNHLSITTFESVWT 297
Cdd:cd17371  178 KE---PPQWQAARAARRHFADRP--------SLRELFSPPLLR--TTLLA-------SLLATGALGGYYGITTWLPSYLT 237

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 169785487 298 DIYNQTPSRAALNYISIAGGFILGSQITGSLNDRI 332
Cdd:cd17371  238 GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI 272
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
63-220 2.73e-09

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 58.88  E-value: 2.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  63 AMPQIATDLNVTDPGMLQAFvSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGa 142
Cdd:PRK10473  25 GLPRIAADLNASEAQLHIAF-SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQG- 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 143 vgsaplsIGAG--------IIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGL 214
Cdd:PRK10473 103 -------IGAGccyvvafaILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSL 175


                 ....*.
gi 169785487 215 CTLRET 220
Cdd:PRK10473 176 FILKET 181
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 59-199 3.68e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 58.40  E-value: 3.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNVTDP--GMLQ-AFVSVYVLgwsFAPlVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLI 135
Cdd:cd17328   17 TIAGVLPDIQSDFLIDDSlaGLLQtVFIISYMV---LSP-IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 169785487 136 LRFITGaVGSAPLS-IGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHT-SWRAIF 199
Cdd:cd17328   93 FRALVG-IGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAF 157
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 50-199 3.69e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 58.36  E-value: 3.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  50 GLISPVIAAIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARS 129
Cdd:cd17504    5 ALAVMLVETMLSPALPTIQREFGTS-AAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169785487 130 DYELLILRFITGAVGSA-PLSIGagIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIF 199
Cdd:cd17504   84 LPVLIAGRALQGIGGAVfPLAFA--LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIF 152
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 51-455 4.44e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 57.97  E-value: 4.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  51 LISPVIAAIIVPAMPQIATDLNVT--DPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFAR 128
Cdd:cd17330    6 FLDALGFGIVFPVLPFYVREFNKLgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 129 SDYELLILRFITGAVGSApLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILI 208
Cdd:cd17330   86 NLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 209 TWVVGLCTLRETFRPVLIqrkqaaavrkgqlpgsvqhhhksladVFrqdlrrpFTFLGTQPIIQVLSLFMGYLFGLNHLS 288
Cdd:cd17330  165 NLVLVLFFLPPLRRLLLV--------------------------YF-------LIALAFAGLESVFSLFLKDRFGFSPSQ 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 289 ITTFesvwtdiynqtpsraalnyISIAGGFILGSQ--ITGSLNDRIyiyytskdpakgtpELRTILMLpAALLVPTGLLI 366
Cdd:cd17330  212 IGLL-------------------LALVGIAGILAQllLIPRLAKRL--------------GERKLLRL-GLLLAIIGLLL 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 367 YGWSAQTHSHWIMpnigIGIYALGLIMSYQCIQAYVLD-CYAVYAASAMGALTILRSLLGFVLPILAPLIYRTLGYGWGS 445
Cdd:cd17330  258 LPFASSVPLLVLA----AAILAFGTGIVFPALSALLSKsVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333

                        410
                 ....*....|
gi 169785487 446 SLLALWALVM 455
Cdd:cd17330  334 LLAAGLLLIA 343
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 55-208 6.20e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.60  E-value: 6.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  55 VIAAIIVPAMpqiATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELL 134
Cdd:cd17365   16 AVMGFVAPAL---AQDWGLS-PAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 169785487 135 ILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILI 208
Cdd:cd17365   92 LLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI 165
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 63-226 3.21e-08

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 55.35  E-value: 3.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  63 AMPQIATDLNvTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGA 142
Cdd:cd17476   20 ILPIIGDSFG-TSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 143 VGSAPLSIGAGIIGDLWAP-EERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRETF 221
Cdd:cd17476   99 GPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTSPSF 178


                 ....*
gi 169785487 222 RPVLI 226
Cdd:cd17476  179 IAVLL 183
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
59-395 5.66e-08

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 54.83  E-value: 5.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNvTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRF 138
Cdd:PRK15403  34 LIQPGIINVVRDFN-ADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 139 ITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLR 218
Cdd:PRK15403 113 IQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMP 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 219 ETfrpvliqrkqaaaVRKGQLPGSVqhhhKSLADVFRQDLRRPFTFLGTqpiiqvLSLFMGYLFGLNHLSITTFesVWTD 298
Cdd:PRK15403 193 ET-------------VKRGAVPFSA----KSVLRDFRNVFRNRLFLTGA------ATLSLSYIPMMSWVAVSPV--ILID 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 299 IYNQTPSRAALNYISIAGGFILGSQITGSLndriyiyytSKDPAkgtpELRTILMLPAALLVPTGLLIYGWSAQTHShWI 378
Cdd:PRK15403 248 AGGMTTSQFAWTQVPVFGAVIVANAIVARF---------VKDPT----EPRFIWRAVPIQLVGLALLIVGNLLWPHV-WL 313

                        330
                 ....*....|....*..
gi 169785487 379 MPNIGIGIYALGLIMSY 395
Cdd:PRK15403 314 WSVLGTSLYAFGIGLIF 330
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 48-212 1.20e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 53.37  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  48 VYGLISPVIAAIIVPAMPQIATDLnvtdpgmlqaFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFA 127
Cdd:cd17316   17 LIGFVAPVLAAEFSLGLSLLQTGL----------LFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 128 RSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTS----WRAIFAWCS 203
Cdd:cd17316   87 PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGA 166


                 ....*....
gi 169785487 204 LYILITWVV 212
Cdd:cd17316  167 LPALLALLL 175
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 58-243 1.68e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 53.35  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  58 AIIVPAMPQIATDLNVTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILR 137
Cdd:cd17473   16 AAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 138 FITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHtSWRAIFAwcsLYiLITWVVGLC-- 215
Cdd:cd17473   96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFL---VY-LLALPVLILvl 170

                        170       180
                 ....*....|....*....|....*....
gi 169785487 216 -TLRETFRPVLIQRKQAAAVRKGQLPGSV 243
Cdd:cd17473  171 lFLPEPARKSKSAASPGAATAAALPWKRV 199
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 58-226 2.30e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 52.58  E-value: 2.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  58 AIIVPAMPQIATDLNVT-DPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLIL 136
Cdd:cd17315   14 GVINGALLYIAKDLGFGlSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 137 RFITG-AVGSAplSIGAGI-IGDLWAPEERGLSISLYTLGPLLGPAIAPITG---AYIVSHtSWRAIFAWCSLYILITWV 211
Cdd:cd17315   94 RFLLGlGVGLA--SVLVPLyISEIAPAKIRGALGTLNQLMITFGILLAYLLGlalSLSPPG-WWRLMFALAAVPALLQLL 170

                        170
                 ....*....|....*
gi 169785487 212 VGLcTLRETfRPVLI 226
Cdd:cd17315  171 LMF-FLPES-RALLV 183
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
60-211 3.06e-07

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 52.63  E-value: 3.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  60 IVPAMPQIATDLNVtDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFI 139
Cdd:PRK15402  32 IQPGMLAVVEDFNA-GAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 140 TGavgsaplsIGAGIIGDLWAP------EERgLSISLYTLG---PLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITW 210
Cdd:PRK15402 111 QG--------IGLCFIGAVGYAaiqesfEEA-DAIKITALManvALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSF 181


                 .
gi 169785487 211 V 211
Cdd:PRK15402 182 F 182
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 83-454 4.68e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 4.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  83 VSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPE 162
Cdd:cd17489   37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 163 ERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRETFRPVLIQRKQAaavrkgqlpgs 242
Cdd:cd17489  117 RRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT----------- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 243 vqhhhksladVFRQDLRRPFTFLGTqpiiqVLSLFMGYLFGlnhlSITTFESVWTDiyNQTPSRAALNYISIAGGFILGS 322
Cdd:cd17489  186 ----------RAFRRLVEKKVLPPA-----LILFLASIAYG----AISTFLPLYAA--ERGISNAGLFFTVYAIALLLSR 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 323 QITGSLNDRiyiyytskdpaKGtpelRTILMLPAALLVPTGLLIygwSAQTHShWIMPNIGIGIYALGLIMSYQCIQAYV 402
Cdd:cd17489  245 PFSGKLSDR-----------KG----PKTVIIPGLLLLALGLLL---LSFAGS-PWMLLLAAVLYGLGFGLLFPALQALA 305

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 169785487 403 LD-CYAVYAASAMGALTILRSLLGFVLPILAPLIYRTLGYGWGSSLLALWALV 454
Cdd:cd17489  306 VDlVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLL 358
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 60-224 1.68e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 49.96  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  60 IVPAMPQIATDLNVTDPGMLQ-----AFVSVYVLGWSFAPlVVGPLSEVYGR-ISLLNTGHGLFLVFNALcAFARSDYEL 133
Cdd:cd17391   15 IAPFLPLYIEQLGVTSGGLVElwsglAFSSTFLVSAIFSP-IWGRLADRYGRkPMLLRASLGMAIVIGLM-AFVTNVWQL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 134 LILRFITGAV-GSAPLSIGagIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVV 212
Cdd:cd17391   93 LILRLLQGVFsGYVPNATA--LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLL 170

                        170
                 ....*....|..
gi 169785487 213 GLCTLRETFRPV 224
Cdd:cd17391  171 TLFFVKEDFKPV 182
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
43-222 2.15e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  43 IAVISVYGLISPVIAAIIVpAMPQIATDLNVTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGR--ISLLNTGHGLFLVF 120
Cdd:COG2271  183 WLLALAYFLVYFALYGFLT-WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 121 NALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFA 200
Cdd:COG2271  262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341

                        170       180
                 ....*....|....*....|..
gi 169785487 201 WCSLYILITWVVGLCTLRETFR 222
Cdd:COG2271  342 LLAALALLAALLALLLLRETRK 363
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 8-208 4.11e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   8 RTRLLSQSDDPSPSLEELEEWEEPRNWKVSYRWLcIAVISVYGLISPVIAAIIVPAMPQIATDLNVTDPGMLQAFVSVYV 87
Cdd:cd17325  167 ALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRR-LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  88 LGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEERGLS 167
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 169785487 168 ISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILI 208
Cdd:cd17325  326 MGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
Sugar_tr pfam00083
Sugar (and other) transporter;
81-233 7.55e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 48.04  E-value: 7.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   81 AFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSD---YELLILRFITGavgsaplsIGAGI--- 154
Cdd:pfam00083  50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKwsvYQLIVGRVLVG--------IGVGGasv 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  155 -----IGDLWAPEERGLSISLYTLGPLLGPAIAPITG---AYIVSHTSWRAIFAWCSLyILITWVVGLCTLRETFRPVLI 226
Cdd:pfam00083 122 lapmyISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLV-PALLLIIGLLFLPESPRWLVE 200


                  ....*..
gi 169785487  227 QRKQAAA 233
Cdd:pfam00083 201 KGRLEEA 207
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 98-236 1.87e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 46.83  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  98 GPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFI--TGAVGSAPLSigagIIGDLWAPEERGLSISLYTLGP 175
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALqgSGAISSVVMA----LLADLTREENRTKAMALIGASI 128

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169785487 176 LLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRETFRPVLIQRKQAAAVRK 236
Cdd:cd17472  129 GIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKK 189
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
31-220 5.44e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.25  E-value: 5.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  31 PRNWKVSYRWLCIAVISVYGLISPVIAAIIvPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLL 110
Cdd:COG2807    9 RRSRRAGRWLLLLAIVLVALNLRPAITSVG-PLLPEIRADLGLS-ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 111 NTGHGLFLVFNALCAFARSDYELLILRFITG---AVGSAPLSigaGIIGDlWAPEERGLSISLYTLGPLLGPAIAPITGA 187
Cdd:COG2807   87 LLALLLLAAGLLLRSLAPSVALLLAGTALIGagiAVGNVLLP---GLIKR-WFPDRVGLMTGLYTAAMGLGAALAAGLTV 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 169785487 188 YIVSHTSWRAIFAWCSLYILITWVVGLCTLRET 220
Cdd:COG2807  163 PLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 51-235 5.88e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.24  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  51 LISPVIAAIIVPAMPQIATDLNVTDpGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSD 130
Cdd:cd17478    6 FLNDFYQGFLPALLPLLIAKLGLSY-AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 131 YELLILRFITGaVGSA---PLsiGAGIIGDLwAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCsLYIL 207
Cdd:cd17478   85 WLLLLLVALAG-IGSAafhPE--GARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL-IIPG 159

                        170       180
                 ....*....|....*....|....*...
gi 169785487 208 ITWVVGLCTLRETFRPVLIQRKQAAAVR 235
Cdd:cd17478  160 LAVALLLLRLRPLKKPEAKKAAAKSSAR 187
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 70-217 6.94e-05

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 45.03  E-value: 6.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  70 DLNVTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRIS-LLNTGHGLFlVFNALCAFARSDYELLILRFITGAVGSAPL 148
Cdd:cd17379   26 NLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVcFLISILGNG-VSGVLMAFSPNYPWFLIFRFLQGLFGKGGW 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169785487 149 SIGAGIIGDLWAPEER---GLSISL-YTLGPLLGPAIapitgAYIVSHTSW--RAIFAWCSLYILITWVVGLCTL 217
Cdd:cd17379  105 MTGYVLVTEFVGSKYRrtvGIVYQMfFTLGLLILPGI-----AYFIPHWRWlqLAVTLPNFLFLLYYWFIPKHTF 174
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 82-223 7.22e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 45.31  E-value: 7.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  82 FVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGaVGSAPLSIGAGIIGDLWAP 161
Cdd:cd06179   37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPN 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169785487 162 EERGLSISLYTLGPLLGPAIAPITGAYIV--SHTSWRAIFawcslYIL-ITWVVGLCTLRETFRP 223
Cdd:cd06179  116 KYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIF-----YINaIFNALALILLFFFYHP 175
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 64-214 7.62e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.89  E-value: 7.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  64 MPQIATDLNVTDPGMlqaFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGAV 143
Cdd:cd17489  217 LPLYAAERGISNAGL---FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG 293

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169785487 144 GSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFAWCSLYILITWVVGL 214
Cdd:cd17489  294 FGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 84-210 2.72e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 42.95  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  84 SVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAPEE 163
Cdd:cd17317   32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 169785487 164 RGLSISLYTLGPLLGPAIAPITgAYIVSHtswraifaWCSLYILITW 210
Cdd:cd17317  112 RSFVGILFGLFWALGYMLLALL-AYLIRD--------WRWLQLAISL 149
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
35-462 3.90e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.53  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  35 KVSYRWLCIAVISVYGLISpVIAAIIVPAMPQIATDLNVTDpGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGH 114
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWG-FATALWGPLIPALKDAFGLSD-AQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 115 GLFLVFNALCAFARSDYELLILRFITGAvGSAPLSIGAGIIGDLWAPEERGLSISL----YTLGPLLGPAIApitGAYIV 190
Cdd:COG0738   81 LLMALGLLLFALAPSYPLLLLALFLLGL-GLGLLDVAANPYVAALGPETAASRLNLlhafFSLGALLGPLLG---GLLIL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 191 SHTS--WRAIFAWCSLYILITWVVGLCTlretfrpvliqrkqaaavrkgQLPGSVQHHHKSLADV--FRQDLRRPFTFLG 266
Cdd:COG0738  157 LGLSlsWHLPYLILAVLLLLLALLFLRS---------------------KLPEIEEEEEEAAGSAasLKSLLKNPRLLLG 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 267 TqpIIQVlsLFMGYLFGLNHLSITTFesvwTDIYNQTPSRAALNYISIAGGFILGSQITGSLNDRIyiyytskdpakgtp 346
Cdd:COG0738  216 G--LAIF--LYVGAEGAIGDWLPLYL----KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-------------- 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 347 ELRTILMLPAALlvptGLLIYGWSAQTHSHWIMpniGIGIYALGLIMS--YQCIQAYVLDCYAVYAASAMGALTILRSLL 424
Cdd:COG0738  274 GPVRLLRLSALL----AAVGLLLALLAPGPWLA---LIGLALVGLGLSlmFPTIFSLALDGLGKRTAAAVSAVLIMGIVG 346

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 169785487 425 GFVLPILAPLIYRTLGYGWGSSLLALWALVMGGLVPIL 462
Cdd:COG0738  347 GAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
31-224 4.58e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 42.60  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  31 PRNWKvsyRWLCIAVISVYglISPVIAAIIVPAMPQIATDLNVTDPGMLQAF----VSVYVLGWSFAPLVVGPLSEVYGR 106
Cdd:PRK09874   9 PINWK---RNLTVAWLGCF--LTGAAFSLVMPFLPLYVEQLGVTGHSALNMWsglvFSITFLFSAIASPFWGGLADRKGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 107 -ISLLNTGHGLFLVFnALCAFARSDYELLILRFITGAVGSAPLSIGAgIIGDLWAPEERGLSISLYTLGPLLGPAIAPIT 185
Cdd:PRK09874  84 kIMLLRSALGMGIVM-VLMGLAQNIWQFLILRALLGLLGGFVPNANA-LIATQVPRNKSGWALGTLSTGGVSGALLGPLA 161

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 169785487 186 GAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRETFRPV 224
Cdd:PRK09874 162 GGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPV 200
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 73-199 5.21e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 42.26  E-value: 5.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  73 VTDPGMLQAF-VSVYVLGWSFA---------PLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGA 142
Cdd:PRK11551  36 VAAPRMAQEFgLDVAQMGWAFSagilgllpgALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 169785487 143 VGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIF 199
Cdd:PRK11551 116 GLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF 172
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 51-214 6.19e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.82  E-value: 6.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  51 LISPVIAAIIVPAMPQIATD---LNVTDPGMLQAFVSVyvLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFA 127
Cdd:cd17331  217 LLSGLPIGMFQSMFSLVAMDffgLTPEENGYLMSYAGV--LGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFV 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 128 RSDYELLILrFITGAVGSAPLSIGAGIIGDLWAPEER-----GLSISLYTLGPLLGPAIapitGAYIVSHTSWRAIFAWC 202
Cdd:cd17331  295 TTVWQLLVL-LLPLVIGGSVLYTVITSLLTKAVPPEDtgtalGLSHALFSLVRTVSPTI----GGALLQAYGFPSFGLLG 369

                        170
                 ....*....|..
gi 169785487 203 SLYILITWVVGL 214
Cdd:cd17331  370 AAINGLLTVYLL 381
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 59-223 6.36e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 41.85  E-value: 6.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLnVTDPGMLQAFVSVYVLGWS-----FAPlVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYEL 133
Cdd:cd17388   17 LIMPVLPTLLREF-VGDSADAATHYGVLLALYAlmqfiFAP-ILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 134 LILRFITGAVGsAPLSIGAGIIGDLWAPEER----GLSISLYTLGPLLGPAIAPITGAYivshtSWRAIFAWCSLYILIT 209
Cdd:cd17388   95 YLGRIIAGITG-ATGAVAAAYIADVTPPEQRarnfGLLGAAFGLGFIAGPALGGLLGEI-----SPRAPFLVAAGLNGLN 168

                        170
                 ....*....|....
gi 169785487 210 WVVGLCTLRETFRP 223
Cdd:cd17388  169 FLLGLFVLPESLPP 182
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 59-190 8.52e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 41.44  E-value: 8.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGR-----ISLLNTGHGLFLVfnalcAFARSDYEL 133
Cdd:cd17390   14 MILPLLSTHIRSLGAS-PTVIGLIGSVYGALQLFSSPLVGSWSDVVGRrpvllICLLLTALGYVLL-----GFSTSLALL 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 169785487 134 LILRFITGAVGSApLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIV 190
Cdd:cd17390   88 FLSRIPLGIFKHT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLA 143
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 63-220 9.67e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.21  E-value: 9.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   63 AMPQI--ATDLNVTDPGMLqafVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFIT 140
Cdd:TIGR00881  17 AMPYLveEIGLSKTDLGLL---LSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  141 GAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAI-APITGAYIVSHTSWRAIFAWCSLYILITWVVGLCTLRE 219
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLlPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRD 173


                  .
gi 169785487  220 T 220
Cdd:TIGR00881 174 S 174
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 62-199 1.01e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.11  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  62 PAMPQIATDLNVT--DPGMLqafVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFI 139
Cdd:cd17312   24 VAKPPIVEEIGLSkdDLGII---GSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 140 TGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIF 199
Cdd:cd17312  101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 82-192 1.08e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.06  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  82 FVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGAVGSAPLSIGAGIIGDLWAP 161
Cdd:cd17329   40 VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP 119

                         90       100       110
                 ....*....|....*....|....*....|.
gi 169785487 162 EERGLSISLYTLGPLLGPAIAPITGAYIVSH 192
Cdd:cd17329  120 ENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 92-220 1.46e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 40.72  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  92 FAPLVVGPLSEVYGRIS-LLNTGHGLFLVFnALCAFARSdYELLILRFITGAVGSAPLSIGAGIIGDLWAPEER------ 164
Cdd:cd17389   79 LSSPITGAASDVYGRKPvLLLTMIGLAISY-ALWAVSRS-FTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRskgmal 156

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 169785487 165 -GLSISL-YTLGPLLGPAIAPITGAYIVSHTSWRAIFAWcsLYILITWVVGLCTLRET 220
Cdd:cd17389  157 iGVAFSLgFIIGPMIGAYFASFTRSLGEVFFSMPALFAL--VLALADLLFIFFFLPET 212
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 59-222 1.50e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 40.72  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLN--VTDPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLIL 136
Cdd:cd17360   15 VISGALLYIKDDLGevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 137 RFITG-AVGSAPLSIGAgIIGDLWAPEERGLSISLYTLGPLLGPAIAP-ITGAYIVSHTSWRAIFAWCSLYILITWvVGL 214
Cdd:cd17360   95 RVLVGlGVGIASMTVPL-YIAEAAPPRIRGRLVTINVLFITGGQFVAYvINGAFSYLPGGWRWMLGLAAVPAVLQF-IGL 172


                 ....*...
gi 169785487 215 CTLRETFR 222
Cdd:cd17360  173 LFLPESPR 180
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 58-222 2.84e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 39.86  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  58 AIIVPAMPQIATDLNVTdPGMLQAFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILR 137
Cdd:cd17359   18 GVINGALPFLQTDFNLT-PFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIAR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 138 FITG-AVGSAPlSIGAGIIGDLWAPEERGLSISLYTLGPLLGP--------AIAPITGAYIVSHTSWRAIFAWCSLYILI 208
Cdd:cd17359   97 IIGGlAVGGAS-ALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQllayivnyLIANAGGADWLGAEGWRWMLGLEAIPAIL 175

                        170
                 ....*....|....
gi 169785487 209 TWvVGLCTLRETFR 222
Cdd:cd17359  176 FL-LGMLFIPESPR 188
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 63-239 4.13e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 39.65  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487   63 AMPQIATDLNVTDPGMLqaFVSVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLV----------FNALCAfarsdyE 132
Cdd:pfam06609  66 ALPNILQDIGQSENQGL--FSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVgaivgctankFNTLLA------A 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  133 LLILRFITGAVGSAPLsigagIIGDLWAPEERGLSISLYTLGPLLGPAIAPITGAYIVSHTSWRAIFawcSLYILITWVV 212
Cdd:pfam06609 138 MTLLGVAAGPAGASPL-----FIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIF---YIYIIMSAIA 209

                         170       180
                  ....*....|....*....|....*..
gi 169785487  213 GLCTLRETFRPVLIQRKQAAAVRKGQL 239
Cdd:pfam06609 210 VLLIIIWYHPPSFAQLHGKKARKRDEL 236
PRK10504 PRK10504
putative transporter; Provisional
 59-199 4.82e-03

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 39.33  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  59 IIVPAMPQIATDLNVTDPGMLQAFVSvYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRF 138
Cdd:PRK10504  28 IVNTALPSMAQSLGESPLHMHMVIVS-YVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARV 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169785487 139 ITGAVGSAPLSIGAGIIGDLWAPEERGLSISLYTL----GPLLGPAIapitGAYIVSHTSWRAIF 199
Cdd:PRK10504 107 LQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLpgqvGPLLGPAL----GGLLVEYASWHWIF 167
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 84-212 8.43e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.43  E-value: 8.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  84 SVYVLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELLILRFITGAvGSAPLSIGAGIIGDLWA-PE 162
Cdd:cd17374   42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGF-AVSGISINTLILGTEWTtPR 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 169785487 163 ERGLSISL----YTLGPLLGPAIapitgAYIVSHtsWR----AIFAWCSLYILITWVV 212
Cdd:cd17374  121 HRALAITLtscfFSIGQMLLAGL-----AYAIRD--WRllqlVVSVPFFLFFLYSWWL 171
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 55-459 9.34e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.07  E-value: 9.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487  55 VIAAIIVPAMPQIATDLNVTDPGMLQAFVSVYvLGWSFAPLVVGPLSEVYGRISLLNTGHGLFLVFNALCAFARSDYELL 134
Cdd:cd17333   10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQN-AGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 135 ILRFITGAVGSAPLSIGAGIIGDLWapEERGLSI-----SLYTLGPLLGPAIApitGAYIVSHTSWRAIFaWCSLYILIt 209
Cdd:cd17333   89 VLMFLAGLGAGILDTGANTFVGALF--EESSATRlnvlhGFFGLGALIGPLIA---TSLLTSELSWSWAY-LIIGLIYL- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 210 wVVGLCTLRETFRPVLIQRKQAAAVRKGQLPGSvqhhhksladvfrQDLRRPFTFLGtqpiiqVLSLFMGYLfglnhlSI 289
Cdd:cd17333  162 -LLAILILLTLFPELPSARNPQQSVGAFSASAS-------------RLLRNPSIILG------ALALFLYVG------AE 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 290 TTFeSVWTDIY----NQTPSRAALNYISI-AGGFILGSQITGSLNDRIyiyytskdpakgtpelrtilmLPAALLVPTGL 364
Cdd:cd17333  216 TAF-SSWVPSYlvekKHVSDGLAGYLLSGfWVGITIGRLLGGPISRRI---------------------KPHTLLVLSGS 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169785487 365 liyGWSAQTHSHWIMPN---IGIGIYALGLIMS--YQCIQAYVLDCYAVYAASAMGALTILRSLLGFVLPILAPLIYRTL 439
Cdd:cd17333  274 ---GALLGLLILLLAPTlvvGLVATALLGLFMAalFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAV 350

                        410       420
                 ....*....|....*....|
gi 169785487 440 GYGWGSSLLALWALVMGGLV 459
Cdd:cd17333  351 GIQTAMLLITILYAIIFVLA 370
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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