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Conserved domains on  [gi|156399895|ref|XP_001638736|]
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protein FAM76B [Nematostella vectensis]

Protein Classification

FAM76 domain-containing protein( domain architecture ID 11240552)

FAM76 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAM76 pfam16046
FAM76 protein; This family of proteins is functionally uncharacterized. This family of ...
 3-295 6.95e-128

FAM76 protein; This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 341 amino acids in length.


:

Pssm-ID: 464993 [Multi-domain]  Cd Length: 303  Bit Score: 366.42  E-value: 6.95e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895    3 LFACTKCHSRHPFEELSRGDQLCKKCRKSFPLVTCTFCRLEFHLLDKTERPVCKKCDSNIKQYGQPTCCVYCNIRAAFNG 82
Cdd:pfam16046   1 LFACTKCFSRHPFEELSSGQQLCKECRGAFPVVKCTYCRSEFQQTSKGTSTICKKCEQNVKQYGKPTACEYCNIIAAFIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895   83 DKCSRCESSEKKYGTPVLCEQCKLKCAFKKSDESKeKVDGKVLCLLCTLSYKRLVHKSKGKVHGRSSSQHKGVKRSHHHP 162
Cdd:pfam16046  81 SKCQRCTNSEKKYGPPVTCEQCKQKCAFDRKDEDK-KVDGKLLCWLCTLSYKRALAKTKQKDAERRSHSKKSKLKSHKSK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895  163 KHEKKSKVAKLQESKQSS--QSSRDSPVTALG-------LYSASSGNSDTGG--EAIMSGQMAELNDLKEQVAKLKRQLQ 231
Cdd:pfam16046 160 KHRLRSQAQINSRSLNSHhsSRPSRVSVTKLGsgplptkISRAKPGNGTSGDtvDPNSSDHVVAITQLKEQIASLQKQLA 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156399895  232 QKDQALLEKEKKLTELKAENWEKEKVSKKKVMSLQKEMTDRIDTLQTENRNLRKQLSSLSRTPK 295
Cdd:pfam16046 240 QKDQQLLEKDKQITELKAKHFTKERELRNKMKTMEKEHEDKVEQLQIKIRSLLKEVATLSKSKK 303
 
Name Accession Description Interval E-value
FAM76 pfam16046
FAM76 protein; This family of proteins is functionally uncharacterized. This family of ...
 3-295 6.95e-128

FAM76 protein; This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 341 amino acids in length.


Pssm-ID: 464993 [Multi-domain]  Cd Length: 303  Bit Score: 366.42  E-value: 6.95e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895    3 LFACTKCHSRHPFEELSRGDQLCKKCRKSFPLVTCTFCRLEFHLLDKTERPVCKKCDSNIKQYGQPTCCVYCNIRAAFNG 82
Cdd:pfam16046   1 LFACTKCFSRHPFEELSSGQQLCKECRGAFPVVKCTYCRSEFQQTSKGTSTICKKCEQNVKQYGKPTACEYCNIIAAFIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895   83 DKCSRCESSEKKYGTPVLCEQCKLKCAFKKSDESKeKVDGKVLCLLCTLSYKRLVHKSKGKVHGRSSSQHKGVKRSHHHP 162
Cdd:pfam16046  81 SKCQRCTNSEKKYGPPVTCEQCKQKCAFDRKDEDK-KVDGKLLCWLCTLSYKRALAKTKQKDAERRSHSKKSKLKSHKSK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895  163 KHEKKSKVAKLQESKQSS--QSSRDSPVTALG-------LYSASSGNSDTGG--EAIMSGQMAELNDLKEQVAKLKRQLQ 231
Cdd:pfam16046 160 KHRLRSQAQINSRSLNSHhsSRPSRVSVTKLGsgplptkISRAKPGNGTSGDtvDPNSSDHVVAITQLKEQIASLQKQLA 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156399895  232 QKDQALLEKEKKLTELKAENWEKEKVSKKKVMSLQKEMTDRIDTLQTENRNLRKQLSSLSRTPK 295
Cdd:pfam16046 240 QKDQQLLEKDKQITELKAKHFTKERELRNKMKTMEKEHEDKVEQLQIKIRSLLKEVATLSKSKK 303
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
214-290 1.27e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.27e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156399895 214 AELNDLKEQVAKLKRQLQQKDQALLEKEKKLTELKAEnwekekvsKKKVMSLQKEMTDRIDTLQTENRNLRKQLSSL 290
Cdd:COG4372   52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQ--------LQAAQAELAQAQEELESLQEEAEELQEELEEL 120
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 214-283 6.10e-03

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 35.23  E-value: 6.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156399895 214 AELNDLKEQVAKLKRQLQQKDQALLEKEKKLTELKAENwekekvskkkvMSLQKEMT---DRIDTLQTENRNL 283
Cdd:cd22887   11 KRLAELEAELASLEEEIKDLEEELKEKNKANEILNDEL-----------IALQIENNlleEKLRKLQEENDEL 72
 
Name Accession Description Interval E-value
FAM76 pfam16046
FAM76 protein; This family of proteins is functionally uncharacterized. This family of ...
 3-295 6.95e-128

FAM76 protein; This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 341 amino acids in length.


Pssm-ID: 464993 [Multi-domain]  Cd Length: 303  Bit Score: 366.42  E-value: 6.95e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895    3 LFACTKCHSRHPFEELSRGDQLCKKCRKSFPLVTCTFCRLEFHLLDKTERPVCKKCDSNIKQYGQPTCCVYCNIRAAFNG 82
Cdd:pfam16046   1 LFACTKCFSRHPFEELSSGQQLCKECRGAFPVVKCTYCRSEFQQTSKGTSTICKKCEQNVKQYGKPTACEYCNIIAAFIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895   83 DKCSRCESSEKKYGTPVLCEQCKLKCAFKKSDESKeKVDGKVLCLLCTLSYKRLVHKSKGKVHGRSSSQHKGVKRSHHHP 162
Cdd:pfam16046  81 SKCQRCTNSEKKYGPPVTCEQCKQKCAFDRKDEDK-KVDGKLLCWLCTLSYKRALAKTKQKDAERRSHSKKSKLKSHKSK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895  163 KHEKKSKVAKLQESKQSS--QSSRDSPVTALG-------LYSASSGNSDTGG--EAIMSGQMAELNDLKEQVAKLKRQLQ 231
Cdd:pfam16046 160 KHRLRSQAQINSRSLNSHhsSRPSRVSVTKLGsgplptkISRAKPGNGTSGDtvDPNSSDHVVAITQLKEQIASLQKQLA 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156399895  232 QKDQALLEKEKKLTELKAENWEKEKVSKKKVMSLQKEMTDRIDTLQTENRNLRKQLSSLSRTPK 295
Cdd:pfam16046 240 QKDQQLLEKDKQITELKAKHFTKERELRNKMKTMEKEHEDKVEQLQIKIRSLLKEVATLSKSKK 303
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
214-290 1.27e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.27e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156399895 214 AELNDLKEQVAKLKRQLQQKDQALLEKEKKLTELKAEnwekekvsKKKVMSLQKEMTDRIDTLQTENRNLRKQLSSL 290
Cdd:COG4372   52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQ--------LQAAQAELAQAQEELESLQEEAEELQEELEEL 120
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 212-305 7.02e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 7.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895 212 QMAELNDLKEQVAKLKRQLQQKDQALLEKEKKLTELKAEnwekekvSKKKVMSLQKEMT---DRIDTLQTENRNLRKQLS 288
Cdd:COG4942  158 DLAELAALRAELEAERAELEALLAELEEERAALEALKAE-------RQKLLARLEKELAelaAELAELQQEAEELEALIA 230

                         90
                 ....*....|....*..
gi 156399895 289 SLSRTPKPEKASASTAS 305
Cdd:COG4942  231 RLEAEAAAAAERTPAAG 247
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 206-305 8.26e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 8.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156399895 206 EAIMSGQMAELNDLKEQVAKLKRQLQQKDQALLEKEKKLTELKAEnwekekvsKKKVMSLQKEMTDRIDTLQTENRNLRK 285
Cdd:COG3883  125 SKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAA--------KAELEAQQAEQEALLAQLSAEEAAAEA 196

                         90       100
                 ....*....|....*....|
gi 156399895 286 QLSSLSRTPKPEKASASTAS 305
Cdd:COG3883  197 QLAELEAELAAAEAAAAAAA 216
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 214-292 5.89e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 37.89  E-value: 5.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156399895 214 AELNDLKEQVAKLKRQLQQKDQALLEKEKKLTELKAEnwekekvskkkvmslQKEMTDRIDTLQTENRNLRKQLSSLSR 292
Cdd:COG3883   30 AELEAAQAELDALQAELEELNEEYNELQAELEALQAE---------------IDKLQAEIAEAEAEIEERREELGERAR 93
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 214-283 6.10e-03

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 35.23  E-value: 6.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156399895 214 AELNDLKEQVAKLKRQLQQKDQALLEKEKKLTELKAENwekekvskkkvMSLQKEMT---DRIDTLQTENRNL 283
Cdd:cd22887   11 KRLAELEAELASLEEEIKDLEEELKEKNKANEILNDEL-----------IALQIENNlleEKLRKLQEENDEL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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