NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|146098479|ref|XP_001468395|]
View 

putative glucose-6-phosphate 1-dehydrogenase [Leishmania infantum JPCM5]

Protein Classification

PTZ00309 family protein( domain architecture ID 11488367)

PTZ00309 family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-562 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 1036.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479   2 SEEQSHADQDAYVADVDGILDVLRAQVLERKPDDifqfisksalslqkdrGAESCDRINCKVKDEQKSRALTIIVFGASG 81
Cdd:PTZ00309   1 APESGRASQSAYVAEVDLITDVLRAQTLVDKPDN----------------GTESCDRIPCKVKDEDKSRALTIIVLGASG 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  82 DLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDVEKWKHETLMKYFSNLSERGCHAEDFLKHISYFCGAYDSVDDFK 161
Cdd:PTZ00309  65 DLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVERWKKETLARFFKRLDDRECHLEQFLKHISYISGSYDEDEDFK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 162 RLDAVIREKENAFKGPEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvgGWVRVIIEKPFGRDTKSSAELSQALEPFFD 241
Cdd:PTZ00309 145 RLNKLIERMEEAFQGPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKN--GWVRVIVEKPFGRDLESSEELSNQLEPLFD 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 242 ESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVMQNHLTQILALLA 321
Cdd:PTZ00309 223 ESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLLQILALLA 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 322 MEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYTASADGSIPGYLEDVTVPEGSTCPTFAVMRLNINNDRWAGVPFI 401
Cdd:PTZ00309 303 MEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAAAVLHINNDRWEGVPFI 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 402 LKAGKAVEQKYVAIRIQFR--DEVHPYGEATQRNELVIRAQPSEAMYVKITTKVPGLSGDLrqtHQTELDLTYHTRYDVR 479
Cdd:PTZ00309 383 LEAGKALEERYVEIRIQFKgvDEFRPSGDDTQRNELVIRAQPSEAMYLKITAKVPGLSNDL---HQTELDLTYKTRYNVR 459

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 480 LPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPIPYQAGTRGPKEADEFIANNGFKHQKGYHWLPS 559
Cdd:PTZ00309 460 LPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNGFKSSKGYQWLQS 539


                 ...
gi 146098479 560 NKL 562
Cdd:PTZ00309 540 NDQ 542
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-562 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 1036.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479   2 SEEQSHADQDAYVADVDGILDVLRAQVLERKPDDifqfisksalslqkdrGAESCDRINCKVKDEQKSRALTIIVFGASG 81
Cdd:PTZ00309   1 APESGRASQSAYVAEVDLITDVLRAQTLVDKPDN----------------GTESCDRIPCKVKDEDKSRALTIIVLGASG 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  82 DLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDVEKWKHETLMKYFSNLSERGCHAEDFLKHISYFCGAYDSVDDFK 161
Cdd:PTZ00309  65 DLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVERWKKETLARFFKRLDDRECHLEQFLKHISYISGSYDEDEDFK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 162 RLDAVIREKENAFKGPEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvgGWVRVIIEKPFGRDTKSSAELSQALEPFFD 241
Cdd:PTZ00309 145 RLNKLIERMEEAFQGPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKN--GWVRVIVEKPFGRDLESSEELSNQLEPLFD 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 242 ESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVMQNHLTQILALLA 321
Cdd:PTZ00309 223 ESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLLQILALLA 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 322 MEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYTASADGSIPGYLEDVTVPEGSTCPTFAVMRLNINNDRWAGVPFI 401
Cdd:PTZ00309 303 MEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAAAVLHINNDRWEGVPFI 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 402 LKAGKAVEQKYVAIRIQFR--DEVHPYGEATQRNELVIRAQPSEAMYVKITTKVPGLSGDLrqtHQTELDLTYHTRYDVR 479
Cdd:PTZ00309 383 LEAGKALEERYVEIRIQFKgvDEFRPSGDDTQRNELVIRAQPSEAMYLKITAKVPGLSNDL---HQTELDLTYKTRYNVR 459

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 480 LPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPIPYQAGTRGPKEADEFIANNGFKHQKGYHWLPS 559
Cdd:PTZ00309 460 LPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNGFKSSKGYQWLQS 539


                 ...
gi 146098479 560 NKL 562
Cdd:PTZ00309 540 NDQ 542
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 74-552 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 619.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479   74 IIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKvddvekWKHETLMKYFSNLSERGCHA------EDFLKHI 147
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRD------WSVEEFRKVVREAIIKFETDeideqwDEFAQRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  148 SYFCGAYDSVDDFKRLDAVIREKEnafKGPEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvGGWVRVIIEKPFGRDTK 227
Cdd:TIGR00871  79 SYVSGDVDDDESYDSLAELLEQLD---KTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQ-GKWSRVVVEKPFGHDLA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  228 SSAELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRD 307
Cdd:TIGR00871 155 SAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  308 VMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITK--ENCVLGQYTASADG--SIPGYLEDVTVPEGSTCPTF 383
Cdd:TIGR00871 235 MVQNHLLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGAGEIGgvSVPGYLEEEGVDKDSNTETF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  384 AVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRDEVHPYGEAT-----QRNELVIRAQPSEAMYVKITTKVPGLSG 458
Cdd:TIGR00871 315 AALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANerdanPRNALVIRIQPDEGVYLKFNAKKPGLNF 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  459 DLRQTHqteLDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDS-GEIKPIPYQAGTRGPK 537
Cdd:TIGR00871 395 ETRPVK---LDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAAnKGPSPPNYPAGSWGPK 471

                         490
                  ....*....|....*
gi 146098479  538 EADEFIANNGFKHQK 552
Cdd:TIGR00871 472 EADELIRKDGRSWRK 486
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 73-560 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 567.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  73 TIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDvEKWK---HETLmKYFSNLSERGCHAEDFLKHISY 149
Cdd:COG0364   11 DLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSD-EEFReevREAL-EEFSRKPFDEEVWERFLERLHY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 150 FCGAYDSVDDFKRLDAVIREKENAFKGpekgGNRLFYLALPPSVFASVCESIHKGAMPQEvGGWVRVIIEKPFGRDTKSS 229
Cdd:COG0364   89 VSGDFTDPEGYERLKELLEELDEERTP----GNRVFYLATPPSLFGPICENLGAAGLATE-GGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 230 AELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVM 309
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 310 QNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKE----NCVLGQYTASA--DGSIPGYLEDVTVPEGSTCPTF 383
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEdvaeNTVRGQYTAGWigGEPVPGYREEPGVAPDSTTETF 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 384 AVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRDEVH-PYGEATQR---NELVIRAQPSEAMYVKITTKVPGLSGD 459
Cdd:COG0364  324 VALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHsLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMR 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 460 LRqthQTELDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPIPYQAGTRGPKEA 539
Cdd:COG0364  404 LR---PVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAA 480

                        490       500
                 ....*....|....*....|.
gi 146098479 540 DEFIANNGFkhqkgyHWLPSN 560
Cdd:COG0364  481 DALLARDGR------SWREPD 495
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
264-556 6.62e-157

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 449.97  E-value: 6.62e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  264 RFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKC 343
Cdd:pfam02781   4 RFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVLRS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  344 IEPITKE----NCVLGQYTASADG--SIPGYLEDVTVPEGSTCPTFAVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRI 417
Cdd:pfam02781  84 LRPITPEdvedNVVRGQYGAGWIGgePVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  418 QFRDEVHPY---GEATQRNELVIRAQPSEAMYVKITTKVPGLSGDLRqthQTELDLTYHTRYDVRLPDAYESLINDALLG 494
Cdd:pfam02781 164 QFKDVPHNLfrdPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLR---PVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146098479  495 NSTNFVRKDELDVAWRIFTPLLHQIDSGeiKPIPYQAGTRGPKEADEFIANNgfkhqkGYHW 556
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWDEE--KPPPYPAGSWGPKAADELLARD------GRKW 294
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-562 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 1036.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479   2 SEEQSHADQDAYVADVDGILDVLRAQVLERKPDDifqfisksalslqkdrGAESCDRINCKVKDEQKSRALTIIVFGASG 81
Cdd:PTZ00309   1 APESGRASQSAYVAEVDLITDVLRAQTLVDKPDN----------------GTESCDRIPCKVKDEDKSRALTIIVLGASG 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  82 DLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDVEKWKHETLMKYFSNLSERGCHAEDFLKHISYFCGAYDSVDDFK 161
Cdd:PTZ00309  65 DLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVERWKKETLARFFKRLDDRECHLEQFLKHISYISGSYDEDEDFK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 162 RLDAVIREKENAFKGPEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvgGWVRVIIEKPFGRDTKSSAELSQALEPFFD 241
Cdd:PTZ00309 145 RLNKLIERMEEAFQGPEKGGNRLFYLALPPSVFASVCEGIHRGCMSKN--GWVRVIVEKPFGRDLESSEELSNQLEPLFD 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 242 ESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVMQNHLTQILALLA 321
Cdd:PTZ00309 223 ESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLLQILALLA 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 322 MEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYTASADGSIPGYLEDVTVPEGSTCPTFAVMRLNINNDRWAGVPFI 401
Cdd:PTZ00309 303 MEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAAAVLHINNDRWEGVPFI 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 402 LKAGKAVEQKYVAIRIQFR--DEVHPYGEATQRNELVIRAQPSEAMYVKITTKVPGLSGDLrqtHQTELDLTYHTRYDVR 479
Cdd:PTZ00309 383 LEAGKALEERYVEIRIQFKgvDEFRPSGDDTQRNELVIRAQPSEAMYLKITAKVPGLSNDL---HQTELDLTYKTRYNVR 459

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 480 LPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPIPYQAGTRGPKEADEFIANNGFKHQKGYHWLPS 559
Cdd:PTZ00309 460 LPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNGFKSSKGYQWLQS 539


                 ...
gi 146098479 560 NKL 562
Cdd:PTZ00309 540 NDQ 542
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 58-554 0e+00

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 626.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  58 RINCKVKDEQKSRA---LTIIVFGASGDLAKKKTFPALFDLYCGGLLPP-EVNIIGYARTKVDDVEKwkHETLMKYFSNL 133
Cdd:PLN02539   1 RNDSFVKEYEKVVEtgcLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPdEVHIFGYARSKITDEEL--RDRIRGYLKDE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 134 SERGC-HAEDFLKHISYFCGAYDSVDDFKRLDAVIREKENAFKGPEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvGG 212
Cdd:PLN02539  79 KNAPAeAVSKFLQLIKYVSGAYDSEEGFRRLDKEISEHEISKNSAEGSSRRLFYLALPPSVYPPVCKMIKKCCMNKS-GL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 213 WVRVIIEKPFGRDTKSSAELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGT 292
Cdd:PLN02539 158 WTRIVVEKPFGKDLESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 293 EGRGGYFDSIGIIRDVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYtasadgsiPGYLEDV 372
Cdd:PLN02539 238 EGRGGYFDEYGIIRDIIQNHLLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEVVLGQY--------EGYRDDP 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 373 TVPEGSTCPTFAVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRDEvhP---YGEATQ-RNELVIRAQPSEAMYVK 448
Cdd:PLN02539 310 TVPDDSNTPTFASVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKDV--PgdiFKCQKQgRNEFVIRLQPSEAMYMK 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 449 ITTKVPGLSgdlRQTHQTELDLTYHTRY-DVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPI 527
Cdd:PLN02539 388 LTVKQPGLE---MSTVQSELDLSYGQRYqDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPI 464

                        490       500
                 ....*....|....*....|....*..
gi 146098479 528 PYQAGTRGPKEADEFIANNGFKHQKGY 554
Cdd:PLN02539 465 PYKQGSRGPAEADELLEKAGYVQTHGY 491
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 74-552 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 619.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479   74 IIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKvddvekWKHETLMKYFSNLSERGCHA------EDFLKHI 147
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRD------WSVEEFRKVVREAIIKFETDeideqwDEFAQRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  148 SYFCGAYDSVDDFKRLDAVIREKEnafKGPEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvGGWVRVIIEKPFGRDTK 227
Cdd:TIGR00871  79 SYVSGDVDDDESYDSLAELLEQLD---KTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQ-GKWSRVVVEKPFGHDLA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  228 SSAELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRD 307
Cdd:TIGR00871 155 SAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  308 VMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITK--ENCVLGQYTASADG--SIPGYLEDVTVPEGSTCPTF 383
Cdd:TIGR00871 235 MVQNHLLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGAGEIGgvSVPGYLEEEGVDKDSNTETF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  384 AVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRDEVHPYGEAT-----QRNELVIRAQPSEAMYVKITTKVPGLSG 458
Cdd:TIGR00871 315 AALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANerdanPRNALVIRIQPDEGVYLKFNAKKPGLNF 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  459 DLRQTHqteLDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDS-GEIKPIPYQAGTRGPK 537
Cdd:TIGR00871 395 ETRPVK---LDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAAnKGPSPPNYPAGSWGPK 471

                         490
                  ....*....|....*
gi 146098479  538 EADEFIANNGFKHQK 552
Cdd:TIGR00871 472 EADELIRKDGRSWRK 486
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 73-549 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 572.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  73 TIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDvEKWK---HETLmKYFSNLSERGCHAEDFLKHISY 149
Cdd:PRK05722  11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSD-EDFRevvREAL-KEFARTPFDEEVWERFLSRLYY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 150 FCGAYDSVDDFKRLDAVIREKENAFkgpEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvGGWVRVIIEKPFGRDTKSS 229
Cdd:PRK05722  89 VSGDVTDPESYERLKELLEELDEER---GTGGNRVFYLATPPSLFGTICENLAAAGLNEG-GGWRRVVIEKPFGHDLASA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 230 AELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVM 309
Cdd:PRK05722 165 RELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 310 QNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKE----NCVLGQYTA--SADGSIPGYLEDVTVPEGSTCPTF 383
Cdd:PRK05722 245 QNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEdvkeNTVRGQYTAgwIGGKPVPGYREEEGVNPDSTTETF 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 384 AVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRDEVHPYGEATQR----NELVIRAQPSEAMYVKITTKVPGLSGD 459
Cdd:PRK05722 325 VALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEelgpNKLVIRIQPDEGISLRFNAKVPGEGME 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 460 LRqthQTELDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPIPYQAGTRGPKEA 539
Cdd:PRK05722 405 LR---PVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAA 481

                        490
                 ....*....|
gi 146098479 540 DEFIANNGFK 549
Cdd:PRK05722 482 DALLARDGRS 491
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 73-560 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 567.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  73 TIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDvEKWK---HETLmKYFSNLSERGCHAEDFLKHISY 149
Cdd:COG0364   11 DLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSD-EEFReevREAL-EEFSRKPFDEEVWERFLERLHY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 150 FCGAYDSVDDFKRLDAVIREKENAFKGpekgGNRLFYLALPPSVFASVCESIHKGAMPQEvGGWVRVIIEKPFGRDTKSS 229
Cdd:COG0364   89 VSGDFTDPEGYERLKELLEELDEERTP----GNRVFYLATPPSLFGPICENLGAAGLATE-GGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 230 AELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVM 309
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 310 QNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKE----NCVLGQYTASA--DGSIPGYLEDVTVPEGSTCPTF 383
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEdvaeNTVRGQYTAGWigGEPVPGYREEPGVAPDSTTETF 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 384 AVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRDEVH-PYGEATQR---NELVIRAQPSEAMYVKITTKVPGLSGD 459
Cdd:COG0364  324 VALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHsLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMR 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 460 LRqthQTELDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPIPYQAGTRGPKEA 539
Cdd:COG0364  404 LR---PVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAA 480

                        490       500
                 ....*....|....*....|.
gi 146098479 540 DEFIANNGFkhqkgyHWLPSN 560
Cdd:COG0364  481 DALLARDGR------SWREPD 495
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
70-547 2.72e-172

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 496.34  E-value: 2.72e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  70 RALTIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDvEKWKhETLMKYFSNLSERGCHA---EDFLKH 146
Cdd:PRK12853   7 PPCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSD-EQWR-ARVRESLRAFGADGFDDavwDRLAAR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 147 ISYFCGAYDSVDDFKRLDAVIREkenafkgpekGGNRLFYLALPPSVFASVCESIHKGAMpqeVGGWVRVIIEKPFGRDT 226
Cdd:PRK12853  85 LSYVQGDVTDPADYARLAEALGP----------GGNPVFYLAVPPSLFAPVVENLGAAGL---LPEGRRVVLEKPFGHDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 227 KSSAELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIR 306
Cdd:PRK12853 152 ASARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 307 DVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKENC--VLGQYTASADG--SIPGYLEDVTVPEGSTCPT 382
Cdd:PRK12853 232 DMVQNHLLQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDVhtVRGQYTAGTVGgePVPGYREEPGVDPDSRTET 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 383 FAVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRDEVHPYGEATQR---NELVIRAQPSEAMYVKITTKVPGLSGD 459
Cdd:PRK12853 312 FVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVeppNRLVIRLQPDEGISLELNVKRPGPGMR 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 460 LRqthQTELDLTYhtRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIKPIPYQAGTRGPKEA 539
Cdd:PRK12853 392 LR---PVELDADY--ADDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAA 466


                 ....*...
gi 146098479 540 DEFIANNG 547
Cdd:PRK12853 467 DALLARDG 474
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 43-536 1.59e-169

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 494.11  E-value: 1.59e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  43 SALSLQKDRGAESCDrINckvkdeQKSRALTIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDVE--K 120
Cdd:PLN02333  96 SIPSSEEDKVVAEFD-GN------KDESTVSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAElrN 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 121 WKHETLMKYFSNLSERGCHAEDFLKHISYFCGAYDSVDDFKRLDAVIREKENAfkgpeKGGNRLFYLALPPSVFASVCES 200
Cdd:PLN02333 169 MVSKTLTCRIDKRENCGEKMEEFLKRCFYHSGQYDSQEHFAELDKKLKEHEGG-----RVSNRLFYLSIPPNIFVDAVKC 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 201 IHKGAmpQEVGGWVRVIIEKPFGRDTKSSAELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIA 280
Cdd:PLN02333 244 ASSSA--SSVNGWTRVIVEKPFGRDSESSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIR 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 281 CVQITFKETIGTEGRGGYFDSIGIIRDVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYTAS 360
Cdd:PLN02333 322 NVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSH 401

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 361 ADGSI--PGYLEDVTVPEGSTCPTFAVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRdevHPYGEATQR------ 432
Cdd:PLN02333 402 TKGGVtyPAYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFR---HVPGNLYNRnfgtdl 478

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 433 ----NELVIRAQPSEAMYVKITTKVPGLSGDLRQTHqteLDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVA 508
Cdd:PLN02333 479 dqatNELVIRVQPDEAIYLKINNKVPGLGMRLDRSN---LNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAA 555

                        490       500
                 ....*....|....*....|....*...
gi 146098479 509 WRIFTPLLHQIDSGEIKPIPYQAGTRGP 536
Cdd:PLN02333 556 WALFTPLLKELEEKKIIPEYYPYGSRGP 583
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 62-536 3.41e-166

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 484.52  E-value: 3.41e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  62 KVKDEQKSRALTIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDVE--KWKHETLMKYFSNLSERGCH 139
Cdd:PLN02640  79 EEHAEKGESTLSITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEElrDMISSTLTCRIDQRENCGDK 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 140 AEDFLKHISYFCGAYDSVDDFKRLDAVIREKENAfkgpeKGGNRLFYLALPPSVFASV--CESIHKGAMpqevGGWVRVI 217
Cdd:PLN02640 159 MDQFLKRCFYHSGQYDSEEDFAELNKKLKEKEAG-----KLSNRLFYLSIPPNIFVDVvrCASLRASSE----NGWTRVI 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 218 IEKPFGRDTKSSAELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGG 297
Cdd:PLN02640 230 VEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGG 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 298 YFDSIGIIRDVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYTASADG--SIPGYLEDVTVP 375
Cdd:PLN02640 310 YFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGgkSYPAYTDDPTVP 389

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 376 EGSTCPTFAVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRIQFRdevHPYGEATQR----------NELVIRAQPSEAM 445
Cdd:PLN02640 390 KHSLTPTFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFR---HVPGNLYKRnfgtdldkatNELVLRVQPDEAI 466

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 446 YVKITTKVPGLSGDLrqtHQTELDLTYHTRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHQIDSGEIK 525
Cdd:PLN02640 467 YLKINNKVPGLGMRL---DRSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKII 543

                        490
                 ....*....|.
gi 146098479 526 PIPYQAGTRGP 536
Cdd:PLN02640 544 PELYPYGSRGP 554
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
264-556 6.62e-157

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 449.97  E-value: 6.62e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  264 RFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGIIRDVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKC 343
Cdd:pfam02781   4 RFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVLRS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  344 IEPITKE----NCVLGQYTASADG--SIPGYLEDVTVPEGSTCPTFAVMRLNINNDRWAGVPFILKAGKAVEQKYVAIRI 417
Cdd:pfam02781  84 LRPITPEdvedNVVRGQYGAGWIGgePVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  418 QFRDEVHPY---GEATQRNELVIRAQPSEAMYVKITTKVPGLSGDLRqthQTELDLTYHTRYDVRLPDAYESLINDALLG 494
Cdd:pfam02781 164 QFKDVPHNLfrdPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLR---PVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146098479  495 NSTNFVRKDELDVAWRIFTPLLHQIDSGeiKPIPYQAGTRGPKEADEFIANNgfkhqkGYHW 556
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWDEE--KPPPYPAGSWGPKAADELLARD------GRKW 294
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 73-556 1.54e-121

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 366.67  E-value: 1.54e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  73 TIIVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDvEKWK---HETLMKYFSnlserGCHAED----FLK 145
Cdd:PRK12854  13 VFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSA-EAFRehaRDALDEFGA-----RKLDDGewarFAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 146 HISYFCGAYDSvDDFKRLDAVIREKEnAFKGPEkgGNRLFYLALPPSVFASVCESIHKGAMpqeVGGwVRVIIEKPFGRD 225
Cdd:PRK12854  87 RLRYVPGGFLS-AGPGALAAAVAAAR-AELGGD--ARLVHYLAVPPSAFLDVTRALGEAGL---AEG-SRVVMEKPFGTD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 226 TKSSAELSQALEPFFDESQLYRIDHYLGKEMVQNIITTRFANRIFSAVWNASNIACVQITFKETIGTEGRGGYFDSIGII 305
Cdd:PRK12854 159 LASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAY 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 306 RDVMQNHLTQILALLAMEKPRSLDAECIRDEKVSVLKCIEPITKENCVLGQYTasadgsipGYLEDVTVPEGSTCPTFAV 385
Cdd:PRK12854 239 RDMVVTHLFQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQYS--------GYRDEPGVAPDSTTETFVA 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 386 MRLNINNDRWAGVPFILKAGK--AVEQKYVAI------RIQFRdevHPYGEATQRNELVIRAQPSEAMYVKITTKVPGLS 457
Cdd:PRK12854 311 LKVWIDNWRWAGVPFYLRTGKrmAEGQRIISIafreppYSMFP---AGSVGAQGPDHLTFDLADNSKVSLSFYGKRPGPG 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479 458 GDLRQTHqteLDLTYH-TRYDVRLPDAYESLINDALLGNSTNFVRKDELDVAWRIFTPLLHqiDSGEIKpiPYQAGTRGP 536
Cdd:PRK12854 388 MRLDKLS---LQFSLKdTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLLE--DPPPVK--PYAPGSWGP 460

                        490       500
                 ....*....|....*....|
gi 146098479 537 KEADEFIANNGFKHQKGYHW 556
Cdd:PRK12854 461 NAIHQLAAPDAWRLPFEREW 480
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
75-259 9.60e-84

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 258.51  E-value: 9.60e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479   75 IVFGASGDLAKKKTFPALFDLYCGGLLPPEVNIIGYARTKVDDvEKWkHETLMKYFSNLSE-RGCHAEDFLKHISYFCGA 153
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSD-EEF-RERVREALKEFKElDEEKWDRFLERLHYVSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146098479  154 YDSVDDFKRLDAVIREKENafkgpEKGGNRLFYLALPPSVFASVCESIHKGAMPQEvGGWVRVIIEKPFGRDTKSSAELS 233
Cdd:pfam00479  79 FDDPESYEKLKERLEEHED-----ETRGNRLFYLAVPPSLFGPIAENLGRAGLSEE-GGWRRVVIEKPFGHDLESARELN 152

                         170       180
                  ....*....|....*....|....*.
gi 146098479  234 QALEPFFDESQLYRIDHYLGKEMVQN 259
Cdd:pfam00479 153 DQLAKVFKEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH