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Conserved domains on  [gi|145253749|ref|XP_001398387|]
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uncharacterized protein An17g01580 [Aspergillus niger]

Protein Classification

STE and zf-H2C2_2 domain-containing protein( domain architecture ID 12032273)

protein containing domains STE, COG5048, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STE pfam02200
STE like transcription factor;
57-165 9.46e-80

STE like transcription factor;


:

Pssm-ID: 366975  Cd Length: 109  Bit Score: 249.13  E-value: 9.46e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145253749   57 QLIRRFLLPTGDYISCVLWSNLFHISGTDIVRCLAFRFQAFGRPVKNSKKFEEGIFSDLRNLKAGTDATLEEPKSPFLDF 136
Cdd:pfam02200   1 QVIRRYYLNNEEYISCVLWNNLFYITGTDIVKCLTYRFEAFGRPITNKKKFEEGIFSDLRNLKPGIDATLEEPKSEFLDF 80

                          90       100
                  ....*....|....*....|....*....
gi 145253749  137 LYKNNCIRTQKKQKVFYWYSVPHDRLFLD 165
Cdd:pfam02200  81 LYKNGCIRTQKKQKVFYWFSVPHDRLFLD 109
zf-H2C2_2 pfam13465
Zinc-finger double domain;
588-613 1.23e-08

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 50.83  E-value: 1.23e-08
                          10        20
                  ....*....|....*....|....*.
gi 145253749  588 HLKRHVRTHTQERPYPCPYCNKAFSR 613
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
566-624 3.77e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.77e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145253749 566 PYPQKSHSCPIpsCGRLFKRLEHLKRHVRTHTQERPYPCPY--CNKAFSRSDNLAQHRRIH 624
Cdd:COG5048   28 SNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
 
Name Accession Description Interval E-value
STE pfam02200
STE like transcription factor;
57-165 9.46e-80

STE like transcription factor;


Pssm-ID: 366975  Cd Length: 109  Bit Score: 249.13  E-value: 9.46e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145253749   57 QLIRRFLLPTGDYISCVLWSNLFHISGTDIVRCLAFRFQAFGRPVKNSKKFEEGIFSDLRNLKAGTDATLEEPKSPFLDF 136
Cdd:pfam02200   1 QVIRRYYLNNEEYISCVLWNNLFYITGTDIVKCLTYRFEAFGRPITNKKKFEEGIFSDLRNLKPGIDATLEEPKSEFLDF 80

                          90       100
                  ....*....|....*....|....*....
gi 145253749  137 LYKNNCIRTQKKQKVFYWYSVPHDRLFLD 165
Cdd:pfam02200  81 LYKNGCIRTQKKQKVFYWFSVPHDRLFLD 109
STE smart00424
STE like transcription factors;
56-165 1.20e-73

STE like transcription factors;


Pssm-ID: 128701  Cd Length: 111  Bit Score: 233.16  E-value: 1.20e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145253749    56 DQLIRRFLLPTGD-YISCVLWSNLFHISGTDIVRCLAFRFQAFGRPVKNSKKFEEGIFSDLRNLKAGTDATLEEPKSPFL 134
Cdd:smart00424   1 NQVIRRYYLPNGEgFVSCVFWNNLYHITGTDIVRCLVYRFQAFGRPVVNRKKFEEGIFSDLRNLKCGTDATLEEPKSPFL 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 145253749   135 DFLYKNNCIRTQKKQKVFYWYSVPHDRLFLD 165
Cdd:smart00424  81 DFLFKNMCLRTQKKQKVFFWFSVPHDRLFAD 111
zf-H2C2_2 pfam13465
Zinc-finger double domain;
588-613 1.23e-08

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 50.83  E-value: 1.23e-08
                          10        20
                  ....*....|....*....|....*.
gi 145253749  588 HLKRHVRTHTQERPYPCPYCNKAFSR 613
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
566-624 3.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.77e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145253749 566 PYPQKSHSCPIpsCGRLFKRLEHLKRHVRTHTQERPYPCPY--CNKAFSRSDNLAQHRRIH 624
Cdd:COG5048   28 SNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 572-596 4.85e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 4.85e-04
                          10        20
                  ....*....|....*....|....*
gi 145253749  572 HSCPIpsCGRLFKRLEHLKRHVRTH 596
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
602-624 1.34e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|...
gi 145253749   602 YPCPYCNKAFSRSDNLAQHRRIH 624
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
STE pfam02200
STE like transcription factor;
57-165 9.46e-80

STE like transcription factor;


Pssm-ID: 366975  Cd Length: 109  Bit Score: 249.13  E-value: 9.46e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145253749   57 QLIRRFLLPTGDYISCVLWSNLFHISGTDIVRCLAFRFQAFGRPVKNSKKFEEGIFSDLRNLKAGTDATLEEPKSPFLDF 136
Cdd:pfam02200   1 QVIRRYYLNNEEYISCVLWNNLFYITGTDIVKCLTYRFEAFGRPITNKKKFEEGIFSDLRNLKPGIDATLEEPKSEFLDF 80

                          90       100
                  ....*....|....*....|....*....
gi 145253749  137 LYKNNCIRTQKKQKVFYWYSVPHDRLFLD 165
Cdd:pfam02200  81 LYKNGCIRTQKKQKVFYWFSVPHDRLFLD 109
STE smart00424
STE like transcription factors;
56-165 1.20e-73

STE like transcription factors;


Pssm-ID: 128701  Cd Length: 111  Bit Score: 233.16  E-value: 1.20e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145253749    56 DQLIRRFLLPTGD-YISCVLWSNLFHISGTDIVRCLAFRFQAFGRPVKNSKKFEEGIFSDLRNLKAGTDATLEEPKSPFL 134
Cdd:smart00424   1 NQVIRRYYLPNGEgFVSCVFWNNLYHITGTDIVRCLVYRFQAFGRPVVNRKKFEEGIFSDLRNLKCGTDATLEEPKSPFL 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 145253749   135 DFLYKNNCIRTQKKQKVFYWYSVPHDRLFLD 165
Cdd:smart00424  81 DFLFKNMCLRTQKKQKVFFWFSVPHDRLFAD 111
zf-H2C2_2 pfam13465
Zinc-finger double domain;
588-613 1.23e-08

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 50.83  E-value: 1.23e-08
                          10        20
                  ....*....|....*....|....*.
gi 145253749  588 HLKRHVRTHTQERPYPCPYCNKAFSR 613
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 602-624 2.67e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.21  E-value: 2.67e-06
                          10        20
                  ....*....|....*....|...
gi 145253749  602 YPCPYCNKAFSRSDNLAQHRRIH 624
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
566-624 3.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.77e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145253749 566 PYPQKSHSCPIpsCGRLFKRLEHLKRHVRTHTQERPYPCPY--CNKAFSRSDNLAQHRRIH 624
Cdd:COG5048   28 SNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 572-596 4.85e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 4.85e-04
                          10        20
                  ....*....|....*....|....*
gi 145253749  572 HSCPIpsCGRLFKRLEHLKRHVRTH 596
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
602-624 1.34e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|...
gi 145253749   602 YPCPYCNKAFSRSDNLAQHRRIH 624
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 602-624 5.46e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.93  E-value: 5.46e-03
                          10        20
                  ....*....|....*....|...
gi 145253749  602 YPCPYCNKAFSRSDNLAQHRRIH 624
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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