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Conserved domains on  [gi|115437672|ref|XP_001217870|]
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uncharacterized protein ATEG_09248 [Aspergillus terreus NIH2624]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10510134)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins

CATH:  3.40.525.10|1.10.8.20
Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 203-308 2.48e-18

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 80.84  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672 203 RREKDTPLTGSVILADASTLTMMQGFDLrGFARDVSGLLSMCYPEIIDKIIICHCPAYMGAIWKIVKGWIDPVTATKLVF 282
Cdd:cd00170   54 LRELEEQVEGFVVIIDLKGFSLSNLSDL-SLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVF 132

                         90       100
                 ....*....|....*....|....*.
gi 115437672 283 LTSGevYPMLSEIIHDEDLPVQFGGK 308
Cdd:cd00170  133 LGSD--LEELLEYIDPDQLPKELGGT 156
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 16-71 4.41e-03

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


:

Pssm-ID: 461043  Cd Length: 53  Bit Score: 34.94  E-value: 4.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672   16 ALATFFQLCAEKnllgrpdGLQDDDANFAI----NDETTLLRFLRARRHDPAAALQQYVE 71
Cdd:pfam03765   1 AYDELLELLKDE-------DEETDREKFWLtredHDDVCLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 203-308 2.48e-18

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 80.84  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672 203 RREKDTPLTGSVILADASTLTMMQGFDLrGFARDVSGLLSMCYPEIIDKIIICHCPAYMGAIWKIVKGWIDPVTATKLVF 282
Cdd:cd00170   54 LRELEEQVEGFVVIIDLKGFSLSNLSDL-SLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVF 132

                         90       100
                 ....*....|....*....|....*.
gi 115437672 283 LTSGevYPMLSEIIHDEDLPVQFGGK 308
Cdd:cd00170  133 LGSD--LEELLEYIDPDQLPKELGGT 156
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 202-310 8.69e-15

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 71.18  E-value: 8.69e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672   202 DRREKDTPLTGSVILADASTLTMMQgFDLrGFARDVSGLLSMCYPEIIDKIIICHCPAYMGAIWKIVKGWIDPVTATKLV 281
Cdd:smart00516  53 QEEKKTGGIEGFTVIFDLKGLSMSN-PDL-SVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIR 130

                           90       100
                   ....*....|....*....|....*....
gi 115437672   282 FLtSGEVYPMLSEIIHDEDLPVQFGGKLE 310
Cdd:smart00516 131 FV-GNDSKEELLEYIDKEQLPEELGGTLD 158
CRAL_TRIO pfam00650
CRAL/TRIO domain;
207-307 9.40e-15

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 70.75  E-value: 9.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672  207 DTPLTGSVILADASTLTMMQ-GFDLRGFARDVSGLLSMCYPEIIDKIIICHCPAYMGAIWKIVKGWIDPVTATKLVFLtS 285
Cdd:pfam00650  51 EGQVEGLTVIIDLKGLSLSNmDWWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFL-K 129

                          90       100
                  ....*....|....*....|..
gi 115437672  286 GEVYPMLSEIIHDEDLPVQFGG 307
Cdd:pfam00650 130 NSNEEELEKYIPPEQLPKEYGG 151
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 16-71 4.41e-03

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 34.94  E-value: 4.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672   16 ALATFFQLCAEKnllgrpdGLQDDDANFAI----NDETTLLRFLRARRHDPAAALQQYVE 71
Cdd:pfam03765   1 AYDELLELLKDE-------DEETDREKFWLtredHDDVCLLRFLRARKWDVEKAIKMLED 53
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
14-71 5.68e-03

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 34.45  E-value: 5.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 115437672    14 KAALATFFQLCAEKNLLGRPDglqDDDAnfaindetTLLRFLRARRHDPAAALQQYVE 71
Cdd:smart01100   1 EEALEELRELLEKHPDLLPPR---LDDA--------FLLRFLRARKFDVEKAKEMLEK 47
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 203-308 2.48e-18

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 80.84  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672 203 RREKDTPLTGSVILADASTLTMMQGFDLrGFARDVSGLLSMCYPEIIDKIIICHCPAYMGAIWKIVKGWIDPVTATKLVF 282
Cdd:cd00170   54 LRELEEQVEGFVVIIDLKGFSLSNLSDL-SLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVF 132

                         90       100
                 ....*....|....*....|....*.
gi 115437672 283 LTSGevYPMLSEIIHDEDLPVQFGGK 308
Cdd:cd00170  133 LGSD--LEELLEYIDPDQLPKELGGT 156
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 202-310 8.69e-15

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 71.18  E-value: 8.69e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672   202 DRREKDTPLTGSVILADASTLTMMQgFDLrGFARDVSGLLSMCYPEIIDKIIICHCPAYMGAIWKIVKGWIDPVTATKLV 281
Cdd:smart00516  53 QEEKKTGGIEGFTVIFDLKGLSMSN-PDL-SVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIR 130

                           90       100
                   ....*....|....*....|....*....
gi 115437672   282 FLtSGEVYPMLSEIIHDEDLPVQFGGKLE 310
Cdd:smart00516 131 FV-GNDSKEELLEYIDKEQLPEELGGTLD 158
CRAL_TRIO pfam00650
CRAL/TRIO domain;
207-307 9.40e-15

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 70.75  E-value: 9.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672  207 DTPLTGSVILADASTLTMMQ-GFDLRGFARDVSGLLSMCYPEIIDKIIICHCPAYMGAIWKIVKGWIDPVTATKLVFLtS 285
Cdd:pfam00650  51 EGQVEGLTVIIDLKGLSLSNmDWWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFL-K 129

                          90       100
                  ....*....|....*....|..
gi 115437672  286 GEVYPMLSEIIHDEDLPVQFGG 307
Cdd:pfam00650 130 NSNEEELEKYIPPEQLPKEYGG 151
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 16-71 4.41e-03

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 34.94  E-value: 4.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115437672   16 ALATFFQLCAEKnllgrpdGLQDDDANFAI----NDETTLLRFLRARRHDPAAALQQYVE 71
Cdd:pfam03765   1 AYDELLELLKDE-------DEETDREKFWLtredHDDVCLLRFLRARKWDVEKAIKMLED 53
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
14-71 5.68e-03

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 34.45  E-value: 5.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 115437672    14 KAALATFFQLCAEKNLLGRPDglqDDDAnfaindetTLLRFLRARRHDPAAALQQYVE 71
Cdd:smart01100   1 EEALEELRELLEKHPDLLPPR---LDDA--------FLLRFLRARKFDVEKAKEMLEK 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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