|
Name |
Accession |
Description |
Interval |
E-value |
| 2met_isocit_dHY |
TIGR02333 |
2-methylisocitrate dehydratase, Fe/S-dependent; Members of this family appear in an operon for ... |
2-864 |
0e+00 |
|
2-methylisocitrate dehydratase, Fe/S-dependent; Members of this family appear in an operon for the degradation of propionyl-CoA via 2-methylcitrate. This family is homologous to aconitases A and B and appears to act the part as 2-methylisocitrate dehydratase, the enzyme after PrpD and before PrpB. In Escherichia coli, which lacks a member of this family, 2-methylisocitrate dehydratase activity was traced to aconitase B (TIGR00117) ().
Pssm-ID: 131386 [Multi-domain] Cd Length: 858 Bit Score: 1730.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 2 NTKYRKPLAGTQLEYYDVRQAVEDIQPGAYEKLPYTSKVLAEQLVRRADAENLTAYLTQLIERRQDLDFPWYPARVVCHD 81
Cdd:TIGR02333 1 NTLYRKPLPGTDLDYFDTRAAVEAIKPGAYDKLPYTSRILAENLVRRCDPETLSASLLQIIERKRDLDFPWYPARVVCHD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 82 ILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGADPDAFAKNRAVEDRRNEDRFHFIEWTKTAFKN 161
Cdd:TIGR02333 81 ILGQTALVDLAGLRDAIAEKGGDPAQVNPVVPTQLIVDHSLAVEYGGFDPDAFEKNRAIEDRRNEDRFHFINWTKTAFKN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 162 VDVIPAGNGIMHQINLEKMSPVIQARDGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGVE 241
Cdd:TIGR02333 161 VDVIPAGNGIMHQINLEKMSPVIQVKNGVAFPDTCVGTDSHTPHVDALGVIAIGVGGLEAETVMLGRASMMRLPDIVGVE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 242 LVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRLTGRE 321
Cdd:TIGR02333 241 LTGKRQPGITATDIVLALTEFLRKERVVSAYLEFFGEGARALTIGDRATISNMTPEYGATAAMFYIDEQTIDYLKLTGRE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 322 DAQVALVEQYAKEIGLWASEMTKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEKGIAGVVENRDDGLMPDGAIII 401
Cdd:TIGR02333 321 PEQVKLVETYAKAAGLWADSLKHAVYERVLEFDLSSVVRNMAGPSNPHARVPTSDLAARGIAGPAEEQPEGLMPDGAVII 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 402 AAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNGMSG 481
Cdd:TIGR02333 401 AAITSCTNTSNPRNVVAAGLLARNANQLGLKRKPWVKTSFAPGSKVAQLYLEEAGLLPELEQLGFGIVAFACTTCNGMSG 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 482 ALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDALGHDKEGNPIYLKDIWP 561
Cdd:TIGR02333 481 ALDPVIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDVLGVDADGKPIRLKDIWP 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 562 SDAEIDALVKQAVKPEQFRKVYIPMFDLGEVEQAKSPLYDWRPQSTYIRRPPYWEGALAAPRTLANMRPLAILGDNITTD 641
Cdd:TIGR02333 561 SDEEIDAVVAAAVKPEQFRKVYIPMFDLDDTQSAVSPLYDWRPMSTYIRRPPYWEGALAGERTLKGMRPLAILGDNITTD 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 642 HLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFANPKLYNEMVrRSDGTIKQGSKARVEPEGEVMRM 721
Cdd:TIGR02333 641 HLSPSNAILADSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMV-KNDGSVKQGSLARIEPEGKVTRM 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 722 WEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKPGVNRKTLKLDGT 801
Cdd:TIGR02333 720 WEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKPGTNRHTLGLDGT 799
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769768980 802 ELYSVIGNIAPRSTLTLVIERATAdgkeEILEVPVTCRLDTEEEVSVYEAGGVLQRFAQDFLE 864
Cdd:TIGR02333 800 ETFDVVGEITPRADLTLVVTRKNG----EKLEVPVTCRLDTAEEVSVYEAGGVLQRFAQDFLE 858
|
|
| PRK09277 |
PRK09277 |
aconitate hydratase AcnA; |
1-865 |
0e+00 |
|
aconitate hydratase AcnA;
Pssm-ID: 236445 [Multi-domain] Cd Length: 888 Bit Score: 1617.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 1 MNTKYRKPL--AGTQLEYYDVRqAVEDIQPGAYEKLPYTSKVLAEQLVRRADAENLT-AYLTQLIER----RQDLDFPWY 73
Cdd:PRK09277 5 DSFKARKTLevGGKSYDYYSLR-ALEAKGLGDISRLPYSLRVLLENLLRNEDGRSVTeEDIEALAEWlpkaKPDREIPFR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 74 PARVVCHDILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGaDPDAFAKNRAVEDRRNEDRFHFIE 153
Cdd:PRK09277 84 PARVVMQDFTGVPAVVDLAAMRDAIADLGGDPAKINPLVPVDLVIDHSVQVDYFG-TPDAFEKNVELEFERNEERYQFLK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 154 WTKTAFKNVDVIPAGNGIMHQINLEKMSPVIQAR-DG--VAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRAS 230
Cdd:PRK09277 163 WGQKAFDNFRVVPPGTGICHQVNLEYLAPVVWTReDGelVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 231 WMRLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQN 310
Cdd:PRK09277 243 SMLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGEGLASLSLADRATIANMAPEYGATCGFFPIDEE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 311 TIDYLRLTGREDAQVALVEQYAKEIGLWASEMTKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEKgIAGVVE--- 387
Cdd:PRK09277 323 TLDYLRLTGRDEEQVALVEAYAKAQGLWRDPLEEPVYTDVLELDLSTVEPSLAGPKRPQDRIPLSDVKEA-FAKSAElgv 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 388 ---------NRDDGLMPDGAIIIAAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALYLEEAGVL 458
Cdd:PRK09277 402 qgfgldeaeEGEDYELPDGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDYLEKAGLL 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 459 KDLEKLGFGIVAYACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRF 538
Cdd:PRK09277 482 PYLEALGFNLVGYGCTTCIGNSGPLPPEIEKAINDNDLVVTAVLSGNRNFEGRIHPLVKANYLASPPLVVAYALAGTVDI 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 539 DIEKDALGHDKEGNPIYLKDIWPSDAEIDALVKQAVKPEQFRKVYIPMFDLGE----VEQAKSPLYDWRPQSTYIRRPPY 614
Cdd:PRK09277 562 DLEKDPLGTDKDGNPVYLKDIWPSDEEIDAVVAKAVKPEMFRKEYADVFEGDErwnaIEVPEGPLYDWDPDSTYIRNPPY 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 615 WEGALAAP---RTLANMRPLAILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFANPK 691
Cdd:PRK09277 642 FEGMLAEPgpvRDIKGARVLALLGDSITTDHISPAGAIKADSPAGKYLLEHGVEPKDFNSYGSRRGNHEVMMRGTFANIR 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 692 LYNEMVRRsdgtiKQGSKARVEPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFER 771
Cdd:PRK09277 722 IRNEMVPG-----VEGGYTRHFPEGEVMSIYDAAMKYKEEGTPLVVIAGKEYGTGSSRDWAAKGTRLLGVKAVIAESFER 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 772 IHRTNLVGMGVLPLEFKPGVNRKTLKLDGTELYSVIG--NIAPRSTLTLVIERatADGkeEILEVPVTCRLDTEEEVSVY 849
Cdd:PRK09277 797 IHRSNLVGMGVLPLQFKPGESRKTLGLDGTETFDIEGleDLKPGATVTVVITR--ADG--EVVEFPVLCRIDTAVEVDYY 872
|
890
....*....|....*.
gi 2769768980 850 EAGGVLQRFAQDFLEG 865
Cdd:PRK09277 873 RNGGILQYVLRDLLAS 888
|
|
| acnA |
PRK12881 |
aconitate hydratase AcnA; |
1-864 |
0e+00 |
|
aconitate hydratase AcnA;
Pssm-ID: 237246 [Multi-domain] Cd Length: 889 Bit Score: 1399.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 1 MNTKYRKPLA----GTQLEYYDVRQAVEDIQPGAYEKLPYTSKVLAEQLVRRADAENLT-----AYLTQLIERRQDLDFP 71
Cdd:PRK12881 1 MAHNLHKTLKefdvGGKTYKFYSLPALGKELGGDLARLPVSLRVLLENLLRNEDGKKVTeehleALANWLPERKSDDEIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 72 WYPARVVCHDILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGaDPDAFAKNRAVEDRRNEDRFHF 151
Cdd:PRK12881 81 FVPARVVMQDFTGVPALVDLAAMRDAAAEAGGDPAKINPLVPVDLVVDHSVAVDYFG-QKDALDLNMKIEFQRNAERYQF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 152 IEWTKTAFKNVDVIPAGNGIMHQINLEKMSPVIQAR----DGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLG 227
Cdd:PRK12881 160 LKWGMQAFDNFRVVPPGTGIMHQVNLEYLARVVHTKeddgDTVAYPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAVMLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 228 RASWMRLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYI 307
Cdd:PRK12881 240 QPVYMLIPDVVGVELTGKLREGVTATDLVLTVTEMLRKEGVVGKFVEFFGEGVASLTLGDRATIANMAPEYGATMGFFPV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 308 DQNTIDYLRLTGREDAQVALVEQYAKEIGLWASEMTKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKE-------K 380
Cdd:PRK12881 320 DEQTLDYLRLTGRTEAQIALVEAYAKAQGLWGDPKAEPRYTRTLELDLSTVAPSLAGPKRPQDRIALGNVKSafsdlfsK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 381 GIAGVVENRD-----DGLMPDGAIIIAAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALYLEEA 455
Cdd:PRK12881 400 PVAENGFAKKaqtsnGVDLPDGAVAIAAITSCTNTSNPSVLIAAGLLAKKAVERGLTVKPWVKTSLAPGSKVVTEYLERA 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 456 GVLKDLEKLGFGIVAYACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGT 535
Cdd:PRK12881 480 GLLPYLEKLGFGIVGYGCTTCIGNSGPLTPEIEQAITKNDLVAAAVLSGNRNFEGRIHPNIKANFLASPPLVVAYALAGT 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 536 IRFDIEKDALGHDKEGNPIYLKDIWPSDAEIDALVKQAVKPEQFRKVYIPMFDLGE----VEQAKSPLYDWRPQSTYIRR 611
Cdd:PRK12881 560 VRRDLMTEPLGKGKDGRPVYLKDIWPSSAEIDALVAFAVDPEDFRKNYAEVFKGSElwaaIEAPDGPLYDWDPKSTYIRR 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 612 PPYWE---GALAAPRTLANMRPLAILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFA 688
Cdd:PRK12881 640 PPFFDfsmGPAASIATVKGARPLAVLGDSITTDHISPAGAIKADSPAGKYLKENGVPKADFNSYGSRRGNHEVMMRGTFA 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 689 NPKLYNEMVRRsdgtiKQGSKARVEPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEG 768
Cdd:PRK12881 720 NVRIKNLMIPG-----KEGGLTLHQPSGEVLSIYDAAMRYQAAGTPLVVIAGEEYGTGSSRDWAAKGTRLLGVKAVIAES 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 769 FERIHRTNLVGMGVLPLEFKPGVNRKTLKLDGTELYSVIG---NIAPRSTLTLVIERatADGKEEilEVPVTCRLDTEEE 845
Cdd:PRK12881 795 FERIHRSNLVGMGVLPLQFKGGDSRQSLGLTGGETFDIEGlpgEIKPRQDVTLVIHR--ADGSTE--RVPVLCRIDTPIE 870
|
890
....*....|....*....
gi 2769768980 846 VSVYEAGGVLQRFAQDFLE 864
Cdd:PRK12881 871 VDYYKAGGILPYVLRQLLA 889
|
|
| AcnA |
COG1048 |
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: ... |
4-865 |
0e+00 |
|
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: Lysine biosynthesisTCA cycle
Pssm-ID: 440669 [Multi-domain] Cd Length: 891 Bit Score: 1359.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 4 KYRKPL--AGTQLEYYDVRQAVEdiQPGAYEKLPYTSKVLAEQLVRRADAENLTAYLTQLI-----ERRQDLDFPWYPAR 76
Cdd:COG1048 6 KARKTLtvGGKPYTYYSLPALEE--AGGDISRLPYSLKILLENLLRNEDGETVTEEDIKALanwlpKARGDDEIPFRPAR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 77 VVCHDILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGaDPDAFAKNRAVEDRRNEDRFHFIEWTK 156
Cdd:COG1048 84 VLMQDFTGVPAVVDLAAMRDAVARLGGDPKKINPLVPVDLVIDHSVQVDYFG-TPDALEKNLELEFERNRERYQFLKWGQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 157 TAFKNVDVIPAGNGIMHQINLEKMSPVIQARDG----VAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWM 232
Cdd:COG1048 163 QAFDNFRVVPPGTGIVHQVNLEYLAFVVWTREEdgetVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 233 RLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTI 312
Cdd:COG1048 243 LIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGPGLASLSLADRATIANMAPEYGATCGFFPVDEETL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 313 DYLRLTGREDAQVALVEQYAKEIGLWASEMTK-AEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEKGIAG------- 384
Cdd:COG1048 323 DYLRLTGRSEEQIELVEAYAKAQGLWRDPDAPePYYSDVLELDLSTVEPSLAGPKRPQDRIPLSDLKEAFRAAlaapvge 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 385 -------VVENRDDGLMPDGAIIIAAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALYLEEAGV 457
Cdd:COG1048 403 eldkpvrVEVDGEEFELGHGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDYLERAGL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 458 LKDLEKLGFGIVAYACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIR 537
Cdd:COG1048 483 LPYLEALGFNVVGYGCTTCIGNSGPLPPEISEAIEENDLVVAAVLSGNRNFEGRIHPDVKANFLASPPLVVAYALAGTVD 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 538 FDIEKDALGHDKEGNPIYLKDIWPSDAEIDALVKQAVKPEQFRKVYIPMFDLGEVEQA----KSPLYDWRPQSTYIRRPP 613
Cdd:COG1048 563 IDLTTDPLGTDKDGKPVYLKDIWPSGEEIPAAVFKAVTPEMFRARYADVFDGDERWQAlevpAGELYDWDPDSTYIRRPP 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 614 YWEGALAAPRTLA---NMRPLAILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFANP 690
Cdd:COG1048 643 FFEGLQLEPEPFKdikGARVLAKLGDSITTDHISPAGAIKADSPAGRYLLEHGVEPKDFNSYGSRRGNHEVMMRGTFANI 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 691 KLYNEMVrrsDGTikQGSKARVEPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFE 770
Cdd:COG1048 723 RIKNLLA---PGT--EGGYTKHQPTGEVMSIYDAAMRYKAEGTPLVVLAGKEYGTGSSRDWAAKGTRLLGVKAVIAESFE 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 771 RIHRTNLVGMGVLPLEFKPGVNRKTLKLDGTELYSVIG---NIAPRSTLTLVIERatADGKEEilEVPVTCRLDTEEEVS 847
Cdd:COG1048 798 RIHRSNLVGMGVLPLQFPEGESAESLGLTGDETFDIEGldeGLAPGKTVTVTATR--ADGSTE--EFPVLHRIDTPVEVE 873
|
890
....*....|....*...
gi 2769768980 848 VYEAGGVLQRFAQDFLEG 865
Cdd:COG1048 874 YYRAGGILQYVLRQLLAA 891
|
|
| PTZ00092 |
PTZ00092 |
aconitate hydratase-like protein; Provisional |
4-856 |
0e+00 |
|
aconitate hydratase-like protein; Provisional
Pssm-ID: 240263 [Multi-domain] Cd Length: 898 Bit Score: 950.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 4 KYRKPLA-GTQLEYYDVRqaveDIQPGAYEKLPYTSKVLAEQLVRRADAENLTAYLTQLI-----ERRQDLDFPWYPARV 77
Cdd:PTZ00092 18 KVLKTLKdGGSYKYYSLN----ELHDPRLKKLPYSIRVLLESAVRNCDEFDVTSKDVENIlnweeNSKKQIEIPFKPARV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 78 VCHDILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGaDPDAFAKNRAVEDRRNEDRFHFIEWTKT 157
Cdd:PTZ00092 94 LLQDFTGVPAVVDLAAMRDAMKRLGGDPAKINPLVPVDLVIDHSVQVDFSR-SPDALELNQEIEFERNLERFEFLKWGSK 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 158 AFKNVDVIPAGNGIMHQINLEKMSPVIQARDGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDI 237
Cdd:PTZ00092 173 AFKNLLIVPPGSGIVHQVNLEYLARVVFNKDGLLYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISMVLPEV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 238 IGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRL 317
Cdd:PTZ00092 253 VGFKLTGKLSEHVTATDLVLTVTSMLRKRGVVGKFVEFYGPGVKTLSLADRATIANMAPEYGATMGFFPIDEKTLDYLKQ 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 318 TGREDAQVALVEQYAKEIGLWASEMTKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEKGIAG------------- 384
Cdd:PTZ00092 333 TGRSEEKVELIEKYLKANGLFRTYAEQIEYSDVLELDLSTVVPSVAGPKRPHDRVPLSDLKKDFTAClsapvgfkgfgip 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 385 ------VVENRDDG---LMPDGAIIIAAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALYLEEA 455
Cdd:PTZ00092 413 eekhekKVKFTYKGkeyTLTHGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVEKGLKVPPYIKTSLSPGSKVVTKYLEAS 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 456 GVLKDLEKLGFGIVAYACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGT 535
Cdd:PTZ00092 493 GLLKYLEKLGFYTAGYGCMTCIGNSGDLDPEVSEAITNNDLVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGR 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 536 IRFDIEKDALGHDKEGNPIYLKDIWPSDAEIDALVKQAVKPEQFRKVYIPMFDLGE----VEQAKSPLYDWRPQSTYIRR 611
Cdd:PTZ00092 573 VNIDFETEPLGSDKTGKPVFLRDIWPSREEIQALEAKYVKPEMFKEVYSNITQGNKqwneLQVPKGKLYEWDEKSTYIHN 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 612 PPYWEGALAAPRT---LANMRPLAILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFA 688
Cdd:PTZ00092 653 PPFFQTMELEPPPiksIENAYCLLNLGDSITTDHISPAGNIAKNSPAAKYLMERGVERKDFNTYGARRGNDEVMVRGTFA 732
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 689 NPKLYNEMVRrsdgtiKQGSKARVEPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEG 768
Cdd:PTZ00092 733 NIRLINKLCG------KVGPNTVHVPTGEKMSIYDAAEKYKQEGVPLIVLAGKEYGSGSSRDWAAKGPYLQGVKAVIAES 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 769 FERIHRTNLVGMGVLPLEFKPGVNRKTLKLDGTELYSV---IGNIAPRSTLTLVieraTADGKeeilEVPVTCRLDTEEE 845
Cdd:PTZ00092 807 FERIHRSNLVGMGILPLQFLNGENADSLGLTGKEQFSIdlnSGELKPGQDVTVK----TDTGK----TFDTILRIDTEVE 878
|
890
....*....|.
gi 2769768980 846 VSVYEAGGVLQ 856
Cdd:PTZ00092 879 VEYFKHGGILQ 889
|
|
| aconitase_1 |
TIGR01341 |
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate ... |
16-863 |
0e+00 |
|
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes. [Energy metabolism, TCA cycle]
Pssm-ID: 273562 [Multi-domain] Cd Length: 876 Bit Score: 941.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 16 YYDVRQAVEdiQPGAYEKLPYTSKVLAEQLVRRADA-----ENLTAYLTQLIERRQDLDFPWYPARVVCHDILGQTALVD 90
Cdd:TIGR01341 5 YYSLKALEE--SGGKISKLPYSIRILLESVLRNLDGfsiteEDIENILKWKIGEVADTEIAFKPARVVMQDFTGVPAVVD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 91 LAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGADpDAFAKNRAVEDRRNEDRFHFIEWTKTAFKNVDVIPAGNG 170
Cdd:TIGR01341 83 LAAMREAMKNLGGDPKKINPLVPVDLVIDHSVQVDYYGTE-YALEFNMELEFERNLERYQFLKWAQKAFRNFRVVPPGTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 171 IMHQINLEKMSPVI----QARDGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGVELVGQR 246
Cdd:TIGR01341 162 IIHQVNLEYLATVVfkaeVDGELTAYPDSLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPYYMNVPEVIGVKLTGKL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 247 QAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRLTGREDAQVA 326
Cdd:TIGR01341 242 QEGVTATDLVLTVTQMLRKKGVVGKFVEFFGPGLSELSLADRATIANMAPEYGATCGFFPIDDVTLQYLRLTGRDGDHVE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 327 LVEQYAKEIGLWASEMTKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEK---------GIAGVVENRD------- 390
Cdd:TIGR01341 322 LVEKYARAQGLFYDDSEEPRYTDVVELDLSDVEPSVAGPKRPQDRIPLREVKAKfskelekngGDKGFTLRKEplkkkvn 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 391 --DGLMPDGAIIIAAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGI 468
Cdd:TIGR01341 402 gqNKQLEDGAVVIAAITSCTNTSNPSVMLGAGLLAKKAVELGLKVPPYVKTSLAPGSKVVTDYLAESGLLPYLEELGFNL 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 469 VAYACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDALGHD 548
Cdd:TIGR01341 482 VGYGCTTCIGNSGPLPKYVEEAIKKNDLEVYAVLSGNRNFEGRIHPLVKGNYLASPPLVVAYALAGNIDINLYTEPIGTD 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 549 KEGNPIYLKDIWPSDAEIDALVKQAVKPEQFRKVYIPMFDLGE----VEQAKSPLYDWRPQSTYIRRPPYWEGALAAPRT 624
Cdd:TIGR01341 562 KDGKPVYLRDIWPSNKEIAAYVNMAVKPEMFKKEYENIFEGNErwnsIKTPSGDTYSWDEKSTYIRLPPFFEEMKQDPEE 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 625 ---LANMRPLAILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFANPKLYNEMVRRsd 701
Cdd:TIGR01341 642 vedIKGARILLLLGDSITTDHISPAGSITKDSPAGKYLQERGVSRRDFNSYGSRRGNHEVMMRGTFANIRIKNLMVKG-- 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 702 gtiKQGSKARVEPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMG 781
Cdd:TIGR01341 720 ---KEGGYTVHFPDGKVASVYDAAMQYKKEGTPLVVIAGKEYGSGSSRDWAAKGTKLLGVKAVIAESFERIHRSNLVGMG 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 782 VLPLEFKPGVNRKTLKLDGTELYSV--IGNIAPRSTLTLVieraTADGKEEILEVPVTCRLDTEEEVSVYEAGGVLQRFA 859
Cdd:TIGR01341 797 VIPLQFPQGEDAETLGLTGDETIDIdgIKDLKPGKEVTVT----FTNSKGEKITFKCVLRIDTEVELDYYKHGGILQYVL 872
|
....
gi 2769768980 860 QDFL 863
Cdd:TIGR01341 873 RKFL 876
|
|
| PLN00070 |
PLN00070 |
aconitate hydratase |
7-856 |
0e+00 |
|
aconitate hydratase
Pssm-ID: 215047 [Multi-domain] Cd Length: 936 Bit Score: 787.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 7 KPLAGTQLEYYDVrQAVEDIQpgaYEKLPYTSKVLAEQLVRRADAENLTAYLTQLI-----ERRQDLDFPWYPARVVCHD 81
Cdd:PLN00070 54 KPGGGEFGKYYSL-PALNDPR---IDKLPYSIRILLESAIRNCDNFQVTKEDVEKIidwenTSPKQVEIPFKPARVLLQD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 82 ILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGAdPDAFAKNRAVEDRRNEDRFHFIEWTKTAFKN 161
Cdd:PLN00070 130 FTGVPAVVDLACMRDAMNNLGGDPNKINPLVPVDLVIDHSVQVDVARS-ENAVQANMELEFQRNKERFAFLKWGSTAFQN 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 162 VDVIPAGNGIMHQINLEKMSPVIQARDGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGVE 241
Cdd:PLN00070 209 MLVVPPGSGIVHQVNLEYLGRVVFNTDGILYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFK 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 242 LVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRLTGRE 321
Cdd:PLN00070 289 LSGKLRDGVTATDLVLTVTQMLRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRS 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 322 DAQVALVEQYakeigLWASEM--------TKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKE------------KG 381
Cdd:PLN00070 369 DETVAMIEAY-----LRANKMfvdynepqQERVYSSYLELDLEDVEPCISGPKRPHDRVPLKEMKAdwhscldnkvgfKG 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 382 IA-------GVVENRDDGL---MPDGAIIIAAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALY 451
Cdd:PLN00070 444 FAvpkeaqsKVAKFSFHGQpaeLRHGSVVIAAITSCTNTSNPSVMLGAGLVAKKACELGLEVKPWIKTSLAPGSGVVTKY 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 452 LEEAGVLKDLEKLGFGIVAYACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYA 531
Cdd:PLN00070 524 LLKSGLQKYLNQQGFHIVGYGCTTCIGNSGELDESVASAITENDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYA 603
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 532 IAGTIRFDIEKDALGHDKEGNPIYLKDIWPSDAEIDALVKQAVKPEQFRKVYI------PMFDlgEVEQAKSPLYDWRPQ 605
Cdd:PLN00070 604 LAGTVDIDFEKEPIGTGKDGKDVFFRDIWPSNEEVAEVVQSSVLPDMFKSTYEaitkgnPMWN--QLSVPSGTLYSWDPK 681
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 606 STYIRRPPYWEGALAAP---RTLANMRPLAILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTA 682
Cdd:PLN00070 682 STYIHEPPYFKNMTMSPpgpHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLMERGVDRKDFNSYGSRRGNDEIM 761
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 683 QRATFANPKLYNEMVRrsdGTIkqGSKARVEPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVE 762
Cdd:PLN00070 762 ARGTFANIRIVNKLLK---GEV--GPKTVHIPTGEKLSVFDAAMKYKSEGHDTIILAGAEYGSGSSRDWAAKGPMLLGVK 836
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 763 AIVAEGFERIHRTNLVGMGVLPLEFKPGVNRKTLKLDGTELYSV-----IGNIAPRSTLTLVieraTADGKEeilevpVT 837
Cdd:PLN00070 837 AVIAKSFERIHRSNLVGMGIIPLCFKSGEDADTLGLTGHERYTIdlpsnISEIKPGQDVTVT----TDNGKS------FT 906
|
890 900
....*....|....*....|.
gi 2769768980 838 C--RLDTEEEVSVYEAGGVLQ 856
Cdd:PLN00070 907 CtlRFDTEVELAYFDHGGILP 927
|
|
| AcnA_IRP |
cd01586 |
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA ... |
76-536 |
0e+00 |
|
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydrolyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes.
Pssm-ID: 153136 Cd Length: 404 Bit Score: 557.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 76 RVVCHDILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGaDPDAFAKNRAVEDRRNEDRFHFIEWT 155
Cdd:cd01586 1 RVILQDFTGVPAVVDLAAMRDAVKRLGGDPEKINPLIPVDLVIDHSVQVDFYG-TADALAKNMKLEFERNRERYEFLKWG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 156 KTAFKNVDVIPAGNGIMHQINLEKMSPVIQAR----DGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASW 231
Cdd:cd01586 80 QKAFKNLRVVPPGTGIIHQVNLEYLARVVFTSeedgDGVAYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPIS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 232 MRLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQnt 311
Cdd:cd01586 160 MLLPEVVGVKLTGKLRPGVTATDLVLTVTQMLRKVGVVGKFVEFFGPGVAKLSVADRATIANMAPEYGATCGFFPVDT-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 312 idylrltgredaqvalveqyakeiglwasemtkaeypRVLRFDLSTVTRNIAGPSNPHARVSTadlkekgiagvvenrdd 391
Cdd:cd01586 238 -------------------------------------QVVELDLSTVEPSVSGPKRPQDRVPL----------------- 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 392 glmpDGAIIIAAITSCTNTSNPRNTVAAGLLARKANELGLVRKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAY 471
Cdd:cd01586 264 ----HGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVELGLKVKPYVKTSLAPGSRVVTKYLEASGLLPYLEKLGFHVVGY 339
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2769768980 472 ACTTCNGMSGALDPAIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 536
Cdd:cd01586 340 GCTTCIGNSGPLPEEVEEAIKENDLVVAAVLSGNRNFEGRIHPLVRANYLASPPLVVAYALAGTV 404
|
|
| Aconitase |
pfam00330 |
Aconitase family (aconitate hydratase); |
64-534 |
5.32e-165 |
|
Aconitase family (aconitate hydratase);
Pssm-ID: 459764 Cd Length: 460 Bit Score: 487.70 E-value: 5.32e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 64 RRQDLDFPWYPARVVCHDILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSlaveyggadPDAFAKNRAVEDR 143
Cdd:pfam00330 10 EELDGSLLYIPDRVLMHDVTSPQAFVDLRAAGRAVRRPGGTPATIDHLVPTDLVIDHA---------PDALDKNIEDEIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 144 RNEDRFHFIEWTKTAFkNVDVIPAGNGIMHQINLEKmspviqardGVAFPD-TCVGTDSHTPHTDALGVISVGVGGLEAE 222
Cdd:pfam00330 81 RNKEQYDFLEWNAKKF-GIRFVPPGQGIVHQVGLEY---------GLALPGmTIVGTDSHTTTHGGLGALAFGVGGSEAE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 223 NVMLGRASWMRLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATA 302
Cdd:pfam00330 151 HVLATQPLEMKKPKVVGVKLTGKLPPGVTAKDVILAIIGKLGVKGGTGKVVEFFGPGVRSLSMEGRATICNMAIEYGATA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 303 AMFYIDQNTIDYLRLTGREDAQValVEQYAKEIGLW---ASEmtKAEYPRVLRFDLSTVTRNIAGPSNPHARVS------ 373
Cdd:pfam00330 231 GLFPPDETTFEYLRATGRPEAPK--GEAYDKAVAWKtlaSDP--GAEYDKVVEIDLSTIEPMVTGPTRPQDAVPlselvp 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 374 ---TADLKEKGIAGVVENRDDGL---MPDGAIIIAAITSCTNTSNPRNTVAAGLLArKANELGLVRKPWVKSSFAPGSKA 447
Cdd:pfam00330 307 dpfADAVKRKAAERALEYMGLGPgtpLSDGKVDIAFIGSCTNSSIEDLRAAAGLLK-KAVEKGLKVAPGVKASVVPGSEV 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 448 AALYLEEAGVLKDLEKLGFGIVAYACTTCNGMSGALDPAiqqeiidrdlyATAVLSGNRNFDGRIHPYAKqAFLASPPLV 527
Cdd:pfam00330 386 VRAYAEAEGLDKILEEAGFEWRGPGCSMCIGNSDRLPPG-----------ERCVSSSNRNFEGRQGPGGR-THLASPALV 453
|
....*..
gi 2769768980 528 VAYAIAG 534
Cdd:pfam00330 454 AAAAIAG 460
|
|
| PRK07229 |
PRK07229 |
aconitate hydratase; Validated |
166-855 |
5.74e-87 |
|
aconitate hydratase; Validated
Pssm-ID: 235974 [Multi-domain] Cd Length: 646 Bit Score: 290.12 E-value: 5.74e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 166 PAGNGIMHQINLEKMspviqardgvAFP-DTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGVELVG 244
Cdd:PRK07229 94 KPGNGICHQVHLERF----------AFPgKTLLGSDSHTPTAGGLGMLAIGAGGLDVALAMAGGPYYLKMPKVVGVKLTG 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 245 QRQAGITATDIVLaltEFLRKERV---VGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRLTGRE 321
Cdd:PRK07229 164 KLPPWVSAKDVIL---ELLRRLTVkggVGKIIEYFGPGVATLSVPERATITNMGAELGATTSIFPSDERTREFLKAQGRE 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 322 DAQVALveqYAKEiglwasemtKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEKGIAGVvenrddglmpdgaiii 401
Cdd:PRK07229 241 DDWVEL---LADP---------DAEYDEVIEIDLSELEPLIAGPHSPDNVVPVSEVAGIKVDQV---------------- 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 402 aAITSCTNTSNPRNTVAAGLL-ARKANElglvrkpwvKSSF--APGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNG 478
Cdd:PRK07229 293 -LIGSCTNSSYEDLMRAASILkGKKVHP---------KVSLviNPGSRQVLEMLARDGALADLIAAGARILENACGPCIG 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 479 MSGAldPAIQQeiidrdlyaTAVLSGNRNFDGRI-HPYAkQAFLASPPLVVAYAIAGTIRfdiekdalghdkegNPIYLK 557
Cdd:PRK07229 363 MGQA--PATGN---------VSLRTFNRNFPGRSgTKDA-QVYLASPETAAASALTGVIT--------------DPRTLA 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 558 DIWPSDAEIDAlvkqavkPEQF---RKVYIPMFDLGE-VEQAKSPlydwrpqstYIRRPPywegALAAPRTLANMRPLAI 633
Cdd:PRK07229 417 LENGEYPKLEE-------PEGFavdDAGIIAPAEDGSdVEVVRGP---------NIKPLP----LLEPLPDLLEGKVLLK 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 634 LGDNITTDHLSPSNAILMdsaageylhkmgvpeedfnSYathRGdHLtaqratfanPKLYNEMVRRSDGTIKQgskarve 713
Cdd:PRK07229 477 VGDNITTDHIMPAGAKWL-------------------PY---RS-NI---------PNISEFVFEGVDNTFPE------- 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 714 pegevmRMWEAIETymnrkqplIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFkpgVNR 793
Cdd:PRK07229 518 ------RAKEQGGG--------IVVGGENYGQGSSREHAALAPRYLGVKAVLAKSFARIHKANLINFGILPLTF---ADP 580
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2769768980 794 K---------TLKLDGTElysvigNIAPRSTLTLVIEraTADgkEEIlevpvTCRLD-TEEEVSVYEAGGVL 855
Cdd:PRK07229 581 AdydkieegdVLEIEDLR------EFLPGGPLTVVNV--TKD--EEI-----EVRHTlSERQIEILLAGGAL 637
|
|
| Aconitase |
cd01351 |
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and ... |
76-536 |
9.20e-79 |
|
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Aconitase catalytic domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. Aconitase, in its active form, contains a 4Fe-4S iron-sulfur cluster; three cysteine residues have been shown to be ligands of the 4Fe-4S cluster. This is the Aconitase core domain, including structural domains 1, 2 and 3, which binds the Fe-S cluster. The aconitase family also contains the following proteins: - Iron-responsive element binding protein (IRE-BP), a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.
Pssm-ID: 153129 [Multi-domain] Cd Length: 389 Bit Score: 260.12 E-value: 9.20e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 76 RVVCHDILGQTALVDLaglrdaiaEKGGDPSKVNPVVPTQLIVDHSLAVEYGgadpdafaknravedrRNEDRFHFIEWT 155
Cdd:cd01351 1 RVMLQDATGPMAMKAF--------EILAALGKVADPSQIACVHDHAVQLEKP----------------VNNEGHKFLSFF 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 156 KTAFKnVDVIPAGNGIMHQINLEKmspviqardGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLP 235
Cdd:cd01351 57 AALQG-IAFYRPGVGIIHQIMVEN---------LALPGDLLVGSDSHTTSYGGLGAISTGAGGGDVAFVMAGGPAWLKKP 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 236 DIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYL 315
Cdd:cd01351 127 EVVGVNLTGKLSPGVTGKDVVLKLGGIVGVDGVLNRIVEFYGEGVSSLSIEDRLTICNMMAELGATTGIFPEDKTTLKWL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 316 RLTGREDAQVALVEqyaKEIGLWASEmtKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEkgiagvvenrddglmp 395
Cdd:cd01351 207 EATGRPLLKNLWLA---FPEELLADE--GAEYDQVIEIDLSELEPDISGPNRPDDAVSVSEVEG---------------- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 396 dGAIIIAAITSCTNtSNPRNTVAAGLLARKAnelglVRKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTT 475
Cdd:cd01351 266 -TKIDQVLIGSCTN-NRYSDMLAAAKLLKGA-----KVAPGVRLIVTPGSRMVYATLSREGYYEILVDSGARILPPGCGP 338
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2769768980 476 CNGMSGALdpaiqqeiidRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 536
Cdd:cd01351 339 CMGNGARL----------VADGEVGVSSGNRNFPGRLGTYERHVYLASPELAAATAIAGKI 389
|
|
| AcnA_IRP_Swivel |
cd01580 |
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, ... |
633-808 |
1.13e-71 |
|
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.
Pssm-ID: 238812 [Multi-domain] Cd Length: 171 Bit Score: 233.32 E-value: 1.13e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 633 ILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFANPKLYNEMVrrsDGTikQGSKARV 712
Cdd:cd01580 1 LLGDSVTTDHISPAGSIAKDSPAGKYLAERGVKPRDFNSYGSRRGNDEVMMRGTFANIRLRNKLV---PGT--EGGTTHH 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 713 EPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKPGVN 792
Cdd:cd01580 76 PPTGEVMSIYDAAMRYKEEGVPLVILAGKEYGSGSSRDWAAKGPFLLGVKAVIAESFERIHRSNLVGMGILPLQFPPGEN 155
|
170
....*....|....*.
gi 2769768980 793 RKTLKLDGTELYSVIG 808
Cdd:cd01580 156 ADSLGLTGEETYDIIG 171
|
|
| AcnA_Mitochondrial |
cd01584 |
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ... |
76-536 |
4.79e-60 |
|
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Mitochondrial aconitase A catalytic domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediary product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. This is the mitochondrial form. The mitochondrial product is coded by a nuclear gene. Most members of this subfamily are mitochondrial but there are some bacterial members.
Pssm-ID: 153134 Cd Length: 412 Bit Score: 209.99 E-value: 4.79e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 76 RVVCHDILGQTALVDL--AGLrdaiaekggdpSKVnpVVPTQLIVDHSLAVEYGGADPDAFAKNRavedrrNEDRFHFIE 153
Cdd:cd01584 1 RVAMQDATAQMALLQFmsSGL-----------PKV--AVPSTIHCDHLIEAQVGGEKDLKRAKDI------NKEVYDFLA 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 154 wTKTAFKNVDVIPAGNGIMHQINLEKMspviqardgvAFPDTC-VGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWM 232
Cdd:cd01584 62 -SAGAKYGIGFWKPGSGIIHQIVLENY----------AFPGLLmIGTDSHTPNAGGLGGIAIGVGGADAVDVMAGIPWEL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 233 RLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTI 312
Cdd:cd01584 131 KCPKVIGVKLTGKLSGWTSPKDVILKVAGILTVKGGTGAIVEYFGPGVDSLSCTGMGTICNMGAEIGATTSVFPYNERMK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 313 DYLRLTGREDAqVALVEQYAKEIgLWASEmtKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEkgiagVVENRDDG 392
Cdd:cd01584 211 KYLKATGRAEI-ADLADEFKDDL-LVADE--GAEYDQLIEINLSELEPHINGPFTPDLATPVSKFKE-----VAEKNGWP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 393 LmpdgAIIIAAITSCTNTSNPRNTVAAGlLARKANELGLVrkpwVKSSF--APGSKAAALYLEEAGVLKDLEKLGFGIVA 470
Cdd:cd01584 282 L----DLRVGLIGSCTNSSYEDMGRAAS-IAKQALAHGLK----CKSIFtiTPGSEQIRATIERDGLLQTFRDAGGIVLA 352
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2769768980 471 YACTTCNGMSGALDpaiqqeiIDRDLYATAVLSGNRNFDGR--IHPyAKQAFLASPPLVVAYAIAGTI 536
Cdd:cd01584 353 NACGPCIGQWDRKD-------IKKGEKNTIVTSYNRNFTGRndANP-ATHAFVASPEIVTAMAIAGTL 412
|
|
| AcnA_Bact |
cd01585 |
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ... |
168-536 |
3.93e-48 |
|
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Bacterial Aconitase-like catalytic domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This distinct subfamily is found only in bacteria and Archaea. Its exact characteristics are not known.
Pssm-ID: 153135 Cd Length: 380 Bit Score: 175.71 E-value: 3.93e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 168 GNGIMHQINLEKMspviqARDGVafpdTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGVELVGQRQ 247
Cdd:cd01585 67 GNGICHQVHLERF-----AVPGK----TLLGSDSHTPTAGGLGMLAIGAGGLDVALAMAGEPYYIPMPKVVGVRLTGELP 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 248 AGITATDIVLaltEFLRKERV---VGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRLTGREDAQ 324
Cdd:cd01585 138 PWVTAKDVIL---ELLRRLTVkggVGKIFEYTGPGVATLSVPERATITNMGAELGATTSIFPSDERTREFLAAQGREDDW 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 325 VALVeqyakeiglwASEmtKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEKGIAGVvenrddglmpdgaiiiaAI 404
Cdd:cd01585 215 VELA----------ADA--DAEYDEEIEIDLSELEPLIARPHSPDNVVPVREVAGIKVDQV-----------------AI 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 405 TSCTNTSNPRNTVAAGLLArkanelGLVRKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNGMSGAld 484
Cdd:cd01585 266 GSCTNSSYEDLMTVAAILK------GRRVHPHVSMVVAPGSKQVLEMLARNGALADLLAAGARILESACGPCIGMGQA-- 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2769768980 485 PAIQqeiidrdlyATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 536
Cdd:cd01585 338 PPTG---------GVSVRTFNRNFEGRSGTKDDLVYLASPEVAAAAALTGVI 380
|
|
| IPMI |
cd01583 |
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and ... |
76-536 |
3.19e-47 |
|
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Aconatase-like catalytic domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes.
Pssm-ID: 153133 Cd Length: 382 Bit Score: 173.14 E-value: 3.19e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 76 RVVCHDILGQTALvdlAGLRDAIAEKGGDPSKvnpvvpTQLIVDHSLAVeyggadPDAFAKNRAVEDRRNEDRFhfiewt 155
Cdd:cd01583 1 LHLVHDVTSPQAF---EGLREAGREKVWDPEK------IVAVFDHNVPT------PDIKAAEQVKTLRKFAKEF------ 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 156 ktAFKNVDVipAGNGIMHQINLEKmspviqardGVAFP-DTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRL 234
Cdd:cd01583 60 --GINFFDV--GRQGICHVILPEK---------GLTLPgMTIVGGDSHTCTHGAFGAFATGIGTTDVAHVLATGKLWFRV 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 235 PDIIGVELVGQRQAGITATDIVLALtefLRKERVVGA-Y--LEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNT 311
Cdd:cd01583 127 PETMRVNVEGKLPPGVTAKDVILYI---IGKIGVDGAtYkaMEFAGEAIESLSMEERMTLCNMAIEAGAKAGIVAPDETT 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 312 IDYLRLTGREDAQValveqyakeiglWASEmTKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTADLKEKGIAGVVenrdd 391
Cdd:cd01583 204 FEYLKGRGKAYWKE------------LKSD-EDAEYDKVVEIDASELEPQVAWPHSPDNVVPVSEVEGIKIDQVF----- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 392 glmpdgaiiiaaITSCTN--TSNPRntVAAGLLarkaneLGLVRKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIV 469
Cdd:cd01583 266 ------------IGSCTNgrLEDLR--AAAEIL------KGRKVADGVRLIVVPASQRVYKQAEKEGLIEIFIEAGAEVR 325
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2769768980 470 AYACTTCNGMS-GALDPaiqqeiidrdlYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 536
Cdd:cd01583 326 PPGCGACLGGHmGVLAP-----------GERCVSTSNRNFKGRMGSPGARIYLASPATAAASAITGEI 382
|
|
| LeuC |
COG0065 |
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism] ... |
73-536 |
4.04e-43 |
|
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Homoaconitase/3-isopropylmalate dehydratase large subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439835 Cd Length: 417 Bit Score: 162.12 E-value: 4.04e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 73 YPARVVCHDILGQTALvdlAGLRDAIAEKGGDPSKvnpvvpTQLIVDHSlaveyggadpdAFAKNRAVEDRRNEDRfhfi 152
Cdd:COG0065 27 YIDLHLVHDVTSPQAF---EGLREAGGRKVWDPDR------IVAVFDHN-----------VPTKDPKSAEQVKTLR---- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 153 EWTKTAfkNVDVIPAG-NGIMHQINLEKmspviqardGVAFP-DTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRAS 230
Cdd:COG0065 83 EFAKEF--GITFFDVGdPGICHVVLPEQ---------GLVLPgMTIVGGDSHTCTHGAFGAFAFGIGTTDVAHVLATGTL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 231 WMRLPDIIGVELVGQRQAGITATDIVLALtefLRKERVVGA-Y--LEFFGEGADSMSVGDRATISNMTPEYGATAAMFYI 307
Cdd:COG0065 152 WFKVPETMRIEVTGKLPPGVTAKDLILAI---IGKIGADGAtGkaIEFAGEAIRALSMEERMTLCNMAIEAGAKAGIIAP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 308 DQNTIDYLRltGREdaqvalveqYAKEIGLWASEmtKAEYPRVLRFDLSTVTRNIAGPSNPhARVSTADlkekGIAGVve 387
Cdd:COG0065 229 DETTFEYLK--GRP---------FAPWRTLKSDE--DAVYDKEVEIDASDLEPQVAWPHSP-DNVVPVS----ELEGI-- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 388 nrddglmpdgAIIIAAITSCTNT--SNPRntVAAGLLA-RKAnelglvrKPWVKSSFAPGSKAAALYLEEAGVLKDLEKL 464
Cdd:COG0065 289 ----------KIDQVFIGSCTNGriEDLR--AAAEILKgRKV-------APGVRAIVVPGSQEVYRQAEAEGLDEIFIEA 349
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769768980 465 GFGIVAYACTTCNGMS-GALDPAiqqeiidrdlyATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 536
Cdd:COG0065 350 GAEWREPGCGMCLGMNmGVLAPG-----------ERCASTSNRNFEGRMGSPGSRTYLASPATAAASAIAGRI 411
|
|
| PRK00402 |
PRK00402 |
3-isopropylmalate dehydratase large subunit; Reviewed |
41-536 |
1.04e-41 |
|
3-isopropylmalate dehydratase large subunit; Reviewed
Pssm-ID: 234748 Cd Length: 418 Bit Score: 158.03 E-value: 1.04e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 41 LAEQLVrrADAENLTAYLTQLIERRQDLdfpwyparVVCHDILGQTALvdlAGLRDAIAEKGGDPSKVnpvvptQLIVDH 120
Cdd:PRK00402 5 LAEKIL--ARHSGRDVSPGDIVEAKVDL--------VMAHDITGPLAI---KEFEKIGGDKVFDPSKI------VIVFDH 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 121 SlaveyggadpdAFAKNRAVEDRRNEDRfhfiEWTK-TAFKNVDVIpaGNGIMHQINLEKmspviqardGVAFP-DTCVG 198
Cdd:PRK00402 66 F-----------VPAKDIKSAEQQKILR----EFAKeQGIPNFFDV--GEGICHQVLPEK---------GLVRPgDVVVG 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 199 TDSHTPHTDALGVISVGVGGLEAENVM-LGRAsWMRLPDIIGVELVGQRQAGITATDIVLALtefLRKERVVGA-Y--LE 274
Cdd:PRK00402 120 ADSHTCTYGALGAFATGMGSTDMAAAMaTGKT-WFKVPETIKVVLEGKLPPGVTAKDVILHI---IGDIGVDGAtYkaLE 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 275 FFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRltgredaqvalvEQYAKEIGLWASEmTKAEYPRVLRFD 354
Cdd:PRK00402 196 FTGETIEALSMDERMTLANMAIEAGAKAGIFAPDEKTLEYLK------------ERAGRDYKPWKSD-EDAEYEEVYEID 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 355 LSTVTRNIAGPSNPhARVSTADlkekGIAGVvenrddglmpdgAIIIAAITSCTN--TSNPRntVAAGLLARKAnelglv 432
Cdd:PRK00402 263 LSKLEPQVAAPHLP-DNVKPVS----EVEGT------------KVDQVFIGSCTNgrLEDLR--IAAEILKGRK------ 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 433 RKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNGMS-GALDPAiqqeiidrdlyATAVLSGNRNFDGR 511
Cdd:PRK00402 318 VAPGVRLIVIPASQKIYLQALKEGLIEIFVDAGAVVSTPTCGPCLGGHmGVLAPG-----------EVCLSTTNRNFKGR 386
|
490 500
....*....|....*....|....*.
gi 2769768980 512 I-HPYAkQAFLASPPLVVAYAIAGTI 536
Cdd:PRK00402 387 MgSPES-EVYLASPAVAAASAVTGKI 411
|
|
| Homoaconitase |
cd01582 |
Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase ... |
162-536 |
1.02e-34 |
|
Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase catalytic domain. Homoaconitase and other uncharacterized proteins of the Aconitase family. Homoaconitase is part of an unusual lysine biosynthesis pathway found only in filamentous fungi, in which lysine is synthesized via the alpha-aminoadipate pathway. In this pathway, homoaconitase catalyzes the conversion of cis-homoaconitic acid into homoisocitric acid. The reaction mechanism is believed to be similar to that of other aconitases.
Pssm-ID: 153132 [Multi-domain] Cd Length: 363 Bit Score: 136.20 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 162 VDVIPAGNGIMHQINLEkmspviqarDGVAFPDT-CVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGV 240
Cdd:cd01582 60 IDFYPAGRGIGHQIMIE---------EGYAFPGTlAVASDSHSNMYGGVGCLGTPIVRTDAAAIWATGQTWWQIPPVAKV 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 241 ELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDqntidylrltgr 320
Cdd:cd01582 131 ELKGQLPKGVTGKDVIVALCGLFNKDQVLNHAIEFTGSGLNSLSVDTRLTIANMTTEWGALSGLFPTD------------ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 321 edaqvalveqyAKEIGLwasemtkaeyprvlrfDLSTVTRNIAGPSNPHARVSTADLKEKGIagvvenrddglmpdgAII 400
Cdd:cd01582 199 -----------AKHLIL----------------DLSTLSPYVSGPNSVKVSTPLKELEAQNI---------------KIN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 401 IAAITSCTNTSNPRNTVAAGLLARKANELGLVRK-PWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNGM 479
Cdd:cd01582 237 KAYLVSCTNSRASDIAAAADVVKGKKEKNGKIPVaPGVEFYVAAASSEVQAAAEKNGDWQTLLEAGATPLPAGCGPCIGL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2769768980 480 -SGALDPAiqqeiidrdlyATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 536
Cdd:cd01582 317 gQGLLEPG-----------EVGISATNRNFKGRMGSTEALAYLASPAVVAASAISGKI 363
|
|
| hacA_fam |
TIGR01343 |
homoaconitate hydratase family protein; This model represents a subfamily of proteins ... |
55-536 |
1.19e-32 |
|
homoaconitate hydratase family protein; This model represents a subfamily of proteins consisting of aconitase, homoaconitase, 3-isopropylmalate dehydratase, and uncharacterized proteins. The majority of the members of this family have been designated as 3-isopropylmalate dehydratase large subunit (LeuC) in microbial genome annotation, but the only characterized member is Thermus thermophilus homoaconitase, an enzyme of a non-aspartate pathway of Lys biosynthesis.
Pssm-ID: 273563 Cd Length: 412 Bit Score: 131.41 E-value: 1.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 55 TAYLTQLIERRQDLdfpwyparVVCHDILGQTALvdlaglrDAIAEKGGDpsKVNPVVPTQLIVDHSlaveyggadpdAF 134
Cdd:TIGR01343 14 EVYAGDLIEAEIDL--------AMVHDITAPLAI-------KTLEEYGID--KVWNPEKIVIVFDHQ-----------VP 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 135 AKNRAVEDRRNEDRfhfiEWTK-TAFKNVdvIPAGNGIMHQINLEKmspviqardGVAFP-DTCVGTDSHTPHTDALGVI 212
Cdd:TIGR01343 66 ADTIKAAEMQKLAR----EFVKkQGIKYF--YDVGEGICHQVLPEK---------GLVKPgDLVVGADSHTCTYGAFGAF 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 213 SVGVGGLEAENVMLGRASWMRLPDIIGVELVGQRQAGITATDIVLaltEFLRKERVVGA-Y--LEFFGEGADSMSVGDRA 289
Cdd:TIGR01343 131 ATGMGSTDMAYAIATGKTWFKVPETIRVNITGKLNPGVTAKDVIL---EVIGEIGVDGAtYmaMEFGGETVKNMDMEGRL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 290 TISNMTPEYGATAAMFYIDQNTIDYLRLTGREDAQVALVEQyakeiglwasemtKAEYPRVLRFDLSTVTRNIAGPSNPH 369
Cdd:TIGR01343 208 TLANMAIEAGGKTGIIEPDEKTIQYLKERRKEPFRVYKSDE-------------DAEYAKEIEIDASQIEPVVACPHNVD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 370 arvstadlKEKGIAGVvenrdDGLMPDGAIIiaaiTSCTNTSNPRNTVAAGLL-ARKAnelglvrKPWVKSSFAPGSKAA 448
Cdd:TIGR01343 275 --------NVKPVSEV-----EGTEIDQVFI----GSCTNGRLEDLRVAAKILkGRKV-------APDVRLIVIPASRAV 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 449 ALYLEEAGVLKDLEKLGFGIVAYACTTCNGM-SGALDPAiqqEIidrdlyatAVLSGNRNFDGRI-HPYAkQAFLASPPL 526
Cdd:TIGR01343 331 YLQALKEGLIEIFVKAGAVVSTPGCGPCLGShQGVLAPG---EV--------CISTSNRNFKGRMgHPNA-EIYLASPAT 398
|
490
....*....|
gi 2769768980 527 VVAYAIAGTI 536
Cdd:TIGR01343 399 AAASAVKGYI 408
|
|
| Aconitase_C |
pfam00694 |
Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This ... |
655-790 |
4.12e-29 |
|
Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This domain undergoes conformational change in the enzyme mechanism.
Pssm-ID: 459908 [Multi-domain] Cd Length: 131 Bit Score: 112.84 E-value: 4.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 655 AGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFANPKLYNEMVRRsdgtiKQGSKARVEPEGEVMRMWEAIETYMNRKQP 734
Cdd:pfam00694 1 MPVFLKLKGKTTPDFNSNVDTDLIIPKQFLGTIANIGIGNINFEG-----WRYGKVRYLPDGENPDFYDAAMRYKQHGAP 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2769768980 735 LIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKPG 790
Cdd:pfam00694 76 IVVIGGKNFGCGSSREHAAWALRDLGIKAVIAESFARIHRNNLIKNGLLPLEFPEE 131
|
|
| PRK12466 |
PRK12466 |
3-isopropylmalate dehydratase large subunit; |
117-536 |
7.22e-25 |
|
3-isopropylmalate dehydratase large subunit;
Pssm-ID: 183543 Cd Length: 471 Bit Score: 109.22 E-value: 7.22e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 117 IVDH--SLAVEYGGADPDAFAKNRAVEDRRNEDRFHfIEwtktafkNVDVIPAGNGIMHqinlekmspVIQARDGVAFPD 194
Cdd:PRK12466 61 VVDHvvPTRPGRDRGITDPGGALQVDYLRENCADFG-IR-------LFDVDDPRQGIVH---------VVAPELGLTLPG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 195 -TCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYL 273
Cdd:PRK12466 124 mVIVCGDSHTTTYGALGALAFGIGTSEVEHVLATQTLVYRKPKTMRVRVDGELPPGVTAKDLILALIARIGADGATGYAI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 274 EFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRltGREDA-QVALVEQyakEIGLWASEMT--KAEYPRV 350
Cdd:PRK12466 204 EFAGEAIRALSMEGRMTLCNMAVEAGARGGLIAPDETTFDYLR--GRPRApKGALWDA---ALAYWRTLRSdaDAVFDRE 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 351 LRFDLSTVTRNIAGPSNP------HARV-STADLKEKGIAGVVENRDD--GLMP-----DGAIIIAAITSCTNT--SNPR 414
Cdd:PRK12466 279 VEIDAADIAPQVTWGTSPdqavpiTGRVpDPAAEADPARRAAMERALDymGLTPgtplaGIPIDRVFIGSCTNGriEDLR 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 415 ntVAAGLLA-RKAnelglvrKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNGMSGALDPAIQQeiid 493
Cdd:PRK12466 359 --AAAAVLRgRKV-------APGVRAMVVPGSGAVRRQAEAEGLARIFIAAGFEWREPGCSMCLAMNDDVLAPGER---- 425
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 2769768980 494 rdlyatAVLSGNRNFDGRIHPYAKqAFLASPPLVVAYAIAGTI 536
Cdd:PRK12466 426 ------CASTTNRNFEGRQGPGAR-THLMSPAMVAAAAVAGHI 461
|
|
| Aconitase_swivel |
cd00404 |
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible ... |
734-808 |
2.59e-20 |
|
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. The aconitase family contains the following proteins: - Iron-responsive element binding protein (IRE-BP). IRE-BP is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.
Pssm-ID: 238236 [Multi-domain] Cd Length: 88 Bit Score: 85.98 E-value: 2.59e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2769768980 734 PLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKPGVNRktLKLDGTELYSVIG 808
Cdd:cd00404 16 PGVVIGDENYGTGSSREHAALELRLLGGRAVIAKSFARIFFRNLVDQGLLPLEFADPEDY--LKLHTGDELDIYP 88
|
|
| PRK05478 |
PRK05478 |
3-isopropylmalate dehydratase large subunit; |
200-536 |
1.00e-17 |
|
3-isopropylmalate dehydratase large subunit;
Pssm-ID: 235490 Cd Length: 466 Bit Score: 87.10 E-value: 1.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 200 DSHTPHTDALGVISVGVGGLEAENVMlgrAS---WMRLPDIIGVELVGQRQAGITATDIVLALtefLRKERV---VGAYL 273
Cdd:PRK05478 128 DSHTSTHGAFGALAFGIGTSEVEHVL---ATqtlLQKKPKTMKIEVDGKLPPGVTAKDIILAI---IGKIGTaggTGYVI 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 274 EFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRltGREDAQVAlvEQYAKEIGLWASEMT--KAEYPRVL 351
Cdd:PRK05478 202 EFAGEAIRALSMEGRMTICNMSIEAGARAGLVAPDETTFEYLK--GRPFAPKG--EDWDKAVAYWKTLKSdeDAVFDKVV 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 352 RFDLS----TVTRNIagpsNPharvstadlkEKGIA--GVVENRDD-----------------GLMP-----DGAIIIAA 403
Cdd:PRK05478 278 TLDAAdiepQVTWGT----NP----------GQVISidGKVPDPEDfadpvkrasaeralaymGLKPgtpitDIKIDKVF 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 404 ITSCTNT--SNPR--------NTVAAGLLArkanelglvrkpWVkssfAPGS---KAAAlylEEAGVLKDLEKLGF---- 466
Cdd:PRK05478 344 IGSCTNSriEDLRaaaavvkgRKVAPGVRA------------LV----VPGSglvKAQA---EAEGLDKIFIEAGFewre 404
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769768980 467 -GivayaCTTCNGMSGalDPAIQQEIidrdlyatAVLSGNRNFDGRihpyakQAF-----LASPPLVVAYAIAGTI 536
Cdd:PRK05478 405 pG-----CSMCLAMNP--DKLPPGER--------CASTSNRNFEGR------QGKggrthLVSPAMAAAAAITGHF 459
|
|
| AcnA_Bact_Swivel |
cd01579 |
Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) ... |
633-788 |
8.27e-17 |
|
Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism. This distinct subfamily is found only in bacteria and archea. Its exact characteristics are not known.
Pssm-ID: 238811 [Multi-domain] Cd Length: 121 Bit Score: 77.09 E-value: 8.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 633 ILGDNITTDHLSPSNAILMDsaageylHKMGVPEedFNSYATHRGDHLTAQRATFANPKlynemvrrsdgtikqgskarv 712
Cdd:cd01579 1 KVGDNITTDHIMPAGAKVLP-------LRSNIPA--ISEFVFHRVDPTFAERAKAAGPG--------------------- 50
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769768980 713 epegevmrmweaietymnrkqplIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFK 788
Cdd:cd01579 51 -----------------------FIVGGENYGQGSSREHAALAPMYLGVRAVLAKSFARIHRANLINFGILPLTFA 103
|
|
| PRK11413 |
PRK11413 |
putative hydratase; Provisional |
165-368 |
6.55e-13 |
|
putative hydratase; Provisional
Pssm-ID: 183125 [Multi-domain] Cd Length: 751 Bit Score: 72.73 E-value: 6.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 165 IPAGNGIMHQINLEKMSpviqardgvafpdTC----VGTDSHTPHtDALGVISVGVGGLEAENVMLGRASWMRLPDIIGV 240
Cdd:PRK11413 123 VPPHIAVIHQYMREMMA-------------GGgkmiLGSDSHTRY-GALGTMAVGEGGGELVKQLLNDTYDIDYPGVVAV 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 241 ELVGQRQAGITATDIVLALT-EFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRLTG 319
Cdd:PRK11413 189 YLTGKPAPGVGPQDVALAIIgAVFKNGYVKNKVMEFVGPGVSALSTDFRNGVDVMTTETTCLSSIWQTDEEVHNWLALHG 268
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2769768980 320 REDAqvalveqYAKeigLWASEMtkAEYPRVLRFDLSTVTRNIAGPSNP 368
Cdd:PRK11413 269 RGQD-------YCE---LNPQPM--AYYDGCISVDLSAIKPMIALPFHP 305
|
|
| IPMI_Swivel |
cd01577 |
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized ... |
736-803 |
8.81e-10 |
|
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.
Pssm-ID: 238809 [Multi-domain] Cd Length: 91 Bit Score: 56.06 E-value: 8.81e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2769768980 736 IIIAGADYGQGSSR---DWAAKGvrlAGVEAIVAEGFERIHRTNLVGMGVLPLEFKPGVNRKTLKLDGTEL 803
Cdd:cd01577 20 IIVAGKNFGCGSSRehaPWALKD---AGIRAVIAESFARIFFRNAINNGLLPVTLADEDVEEVEAKPGDEV 87
|
|
| AcnA_Mitochon_Swivel |
cd01578 |
Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and ... |
734-788 |
1.75e-09 |
|
Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. This is the mitochondrial form. The mitochondrial product is coded by a nuclear gene. Most members of this subfamily are mitochondrial but there are some bacterial members.
Pssm-ID: 238810 [Multi-domain] Cd Length: 149 Bit Score: 57.09 E-value: 1.75e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2769768980 734 PLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFK 788
Cdd:cd01578 70 KWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFA 124
|
|
| LeuD |
COG0066 |
3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; ... |
736-786 |
5.39e-09 |
|
3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; 3-isopropylmalate dehydratase small subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439836 [Multi-domain] Cd Length: 195 Bit Score: 56.72 E-value: 5.39e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2769768980 736 IIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLE 786
Cdd:COG0066 67 ILVAGRNFGCGSSREHAPWALKDYGFRAVIAPSFADIFYRNAINNGLLPIE 117
|
|
| PRK14023 |
PRK14023 |
homoaconitate hydratase small subunit; Provisional |
736-786 |
8.07e-09 |
|
homoaconitate hydratase small subunit; Provisional
Pssm-ID: 184460 [Multi-domain] Cd Length: 166 Bit Score: 55.58 E-value: 8.07e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2769768980 736 IIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLE 786
Cdd:PRK14023 52 ILVAGRNFGLGSSREYAPEALKMLGIGAIIAKSYARIFYRNLVNLGIPPFE 102
|
|
| leuD |
PRK00439 |
3-isopropylmalate dehydratase small subunit; Reviewed |
736-786 |
1.64e-08 |
|
3-isopropylmalate dehydratase small subunit; Reviewed
Pssm-ID: 234762 [Multi-domain] Cd Length: 163 Bit Score: 54.83 E-value: 1.64e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2769768980 736 IIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLE 786
Cdd:PRK00439 51 IIVAGKNFGCGSSREHAPIALKAAGVSAVIAKSFARIFYRNAINIGLPVLE 101
|
|
| AcnB |
cd01581 |
Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA ... |
193-536 |
2.23e-07 |
|
Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Aconitase B catalytic domain. Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle. Aconitase has an active (4FE-4S) and an inactive (3FE-4S) form. The active cluster is part of the catalytic site that interconverts citrate, cis-aconitase and isocitrate. The domain architecture of aconitase B is different from other aconitases in that the catalytic domain is normally found at C-terminus for other aconitases, but it is at N-terminus for B family. It also has a HEAT domain before domain 4 which plays a role in protein-protein interaction. This alignment is the core domain including domains 1,2 and 3.
Pssm-ID: 153131 Cd Length: 436 Bit Score: 54.04 E-value: 2.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 193 PDTC-VGTDSHTPHtdALGvISVGVG-GLEAENVMLGRASwMRLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVV- 269
Cdd:cd01581 106 PDTVgTGGDSHTRF--PIG-ISFPAGsGLVAFAAATGVMP-LDMPESVLVRFKGKMQPGITLRDLVNAIPYYAIQQGLLt 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 270 -----------GAYLEFfgEGADSMSVGDRATISNMTPEYGATAAMFYIDQNT-IDYLRLT----------GREDAQVAL 327
Cdd:cd01581 182 vekkgkknvfnGRILEI--EGLPDLKVEQAFELTDASAERSAAACTVRLDKEPvIEYLESNvvlmkimianGYDDARTLL 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 328 VEQYAKEIGLWASEMTK----AEYPRVLRFDLSTVTRNI-AGPSNPHARVSTADLKEKGIagvvenrDDGLmpdgaiiia 402
Cdd:cd01581 260 RRIIAMEEWLANPPLLEpdadAEYAAVIEIDLDDIKEPIlACPNDPDDVKLLSEVAGKKI-------DEVF--------- 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 403 aITSC-TNTSNPRntVAAGLLARKANELGLVrkpWVkssfAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNGMsg 481
Cdd:cd01581 324 -IGSCmTNIGHFR--AAAKILRGKEFKPTRL---WV----APPTRMDWAILQEEGYYSIFGDAGARTEMPGCSLCMGN-- 391
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2769768980 482 aldpaiQQEIIDRDlyaTAVLSGNRNFDGRIHPYAkQAFLASPPLVVAYAIAGTI 536
Cdd:cd01581 392 ------QARVADGA---TVFSTSTRNFDNRVGKGA-EVYLGSAELAAVCALLGRI 436
|
|
| PLN00072 |
PLN00072 |
3-isopropylmalate isomerase/dehydratase small subunit; Provisional |
633-786 |
7.29e-07 |
|
3-isopropylmalate isomerase/dehydratase small subunit; Provisional
Pssm-ID: 177701 [Multi-domain] Cd Length: 246 Bit Score: 51.40 E-value: 7.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769768980 633 ILGDNITTDHLSPSNAI-LMDSAAGEYlhkmgvpeEDFNSYAThrgdhltaqratFANPKLYNEMVrrsdgtikqgskar 711
Cdd:PLN00072 75 VVGDNIDTDQIIPAEYLtLVPSKPDEY--------EKLGSYAL------------IGLPAFYKTRF-------------- 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769768980 712 VEPeGEvmrmweaietymNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMG-VLPLE 786
Cdd:PLN00072 121 VEP-GE------------MKTKYSIIIGGENFGCGSSREHAPVALGAAGAKAVVAESYARIFFRNSVATGeVYPLE 183
|
|
| leuD |
PRK01641 |
3-isopropylmalate dehydratase small subunit; |
736-784 |
2.02e-03 |
|
3-isopropylmalate dehydratase small subunit;
Pssm-ID: 179314 [Multi-domain] Cd Length: 200 Bit Score: 40.50 E-value: 2.02e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2769768980 736 IIIAGADYGQGSSRD---WAakgvrLA--GVEAIVAEGFERIHRTNLVGMGVLP 784
Cdd:PRK01641 70 ILLAGDNFGCGSSREhapWA-----LAdyGFRAVIAPSFADIFYNNCFKNGLLP 118
|
|
| |
