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Conserved domains on  [gi|2769516351|ref|WP_366439858|]
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futalosine hydrolase [Streptomyces sp. NPDC091278]

Protein Classification

futalosine hydrolase( domain architecture ID 10013027)

futalosine hydrolase converts futalosine into dehypoxanthinyl futalosine in the biosynthesis of menaquinone

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08236 PRK08236
hypothetical protein; Provisional
 4-239 2.47e-59

hypothetical protein; Provisional


:

Pssm-ID: 236194  Cd Length: 212  Bit Score: 186.80  E-value: 2.47e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351   4 RSLIVTAVAAEADSVSAGLGphlggpvllplpgglvlrrhtaGPVRVDVLVGGVGPAAVAAATGTAltsaaLTDPDAPYG 83
Cdd:PRK08236    3 RVLVVTAVPAERDAVLRGLG----------------------NDSRFDVLAAGVGPAAAAASTARA-----LAAAAAPYD 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  84 LVVSAGIAGGFLPLAPLGSVVVSASVVAADLGARTPDAYLTVEELGFGRSVHPVPDALTGRISAALTAGHLPHAVAPVLT 163
Cdd:PRK08236   56 LVVSAGIAGGFPGKAEVGSLVVADEIIAADLGAETPDGFLPVDELGFGTTTIQVDPALVRQLTEALLAAALGATAGPVLT 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769516351 164 VSTVTGTADRAAELAGRHPGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALESLRRAFELL 239
Cdd:PRK08236  136 VSTVTGTAETAAALAARHPDAVAEAMEGFGVAEAAAAAGLPVLELRAISNPVGPRDRAAWRIKEALAALTAASSVL 211
 
Name Accession Description Interval E-value
PRK08236 PRK08236
hypothetical protein; Provisional
 4-239 2.47e-59

hypothetical protein; Provisional


Pssm-ID: 236194  Cd Length: 212  Bit Score: 186.80  E-value: 2.47e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351   4 RSLIVTAVAAEADSVSAGLGphlggpvllplpgglvlrrhtaGPVRVDVLVGGVGPAAVAAATGTAltsaaLTDPDAPYG 83
Cdd:PRK08236    3 RVLVVTAVPAERDAVLRGLG----------------------NDSRFDVLAAGVGPAAAAASTARA-----LAAAAAPYD 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  84 LVVSAGIAGGFLPLAPLGSVVVSASVVAADLGARTPDAYLTVEELGFGRSVHPVPDALTGRISAALTAGHLPHAVAPVLT 163
Cdd:PRK08236   56 LVVSAGIAGGFPGKAEVGSLVVADEIIAADLGAETPDGFLPVDELGFGTTTIQVDPALVRQLTEALLAAALGATAGPVLT 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769516351 164 VSTVTGTADRAAELAGRHPGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALESLRRAFELL 239
Cdd:PRK08236  136 VSTVTGTAETAAALAARHPDAVAEAMEGFGVAEAAAAAGLPVLELRAISNPVGPRDRAAWRIKEALAALTAASSVL 211
futalosine_nucleosidase_MqnB cd17766
futalosine nucleosidase which catalyzes the hydrolysis of futalosine to ...
 80-239 8.81e-52

futalosine nucleosidase which catalyzes the hydrolysis of futalosine to dehypoxanthinylfutalosine and a hypoxanthine base; similar to Thermus thermophiles MqnB; Futalosine nucleosidase (MqnB, EC 3.2.2.26, also known as futalosine hydrolase) functions in an alternative menaquinone biosynthetic pathway (the futalosine pathway) which operates in some bacteria, including Streptomyces coelicolor and Thermus thermophiles. This domain model belongs to the PNP_UDP_1 superfamily which includes members which accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. PNP_UDP_1 includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Superfamily members have different physiologically relevant quaternary structures: hexameric such as the trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP, homotrimeric such as human PNP and Escherichia coli PNPII (XapA), homohexomeric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD), or homodimeric such as human and Trypanosoma brucei UP. The PNP_UDP_2 (nucleoside phosphorylase-II family) is a different structural family.


Pssm-ID: 350166  Cd Length: 217  Bit Score: 167.71  E-value: 8.81e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  80 APYGLVVSAGIAGGFLP-LAPLGSVVVSASVVAADLGARTPDAYLTVEELGFGRSVHPVPDALTGRISAALTAGHLPHAV 158
Cdd:cd17766    57 HPPDLVINAGIAGAFPGsGLSVGDLVVASEEIAADLGVETPEGFLSLDELGFGLLRIGTDPYLNRFPLSALLLAAGLQVK 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351 159 -APVLTVSTVTGTADRAAELAGRHPGAgAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALESLRRAFE 237
Cdd:cd17766   137 tGPFLTVSTVTGTAERAAELQRRFPAI-AENMEGAAVAHAALLYGVPFLEIRGISNPVGPRDRSAWDIPEALEALQRAVL 215


                  ..
gi 2769516351 238 LL 239
Cdd:cd17766   216 AL 217
fut_nucase TIGR03664
futalosine hydrolase; This enzyme catalyzes the conversion of futalosine to de-hypoxanthine ...
 80-239 6.87e-42

futalosine hydrolase; This enzyme catalyzes the conversion of futalosine to de-hypoxanthine futalosine in a pathway for the biosynthesis of menaquinone distinct from the pathway observed in E. coli.


Pssm-ID: 274710  Cd Length: 222  Bit Score: 142.44  E-value: 6.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  80 APYGLVVSAGIAGGFLPLAPLGSVVVSASVVAADLGARTPDAYLTVEELGFGRSVH---------PVPDALTGRISAALT 150
Cdd:TIGR03664  54 APYELVINAGIAGGFPGKAAVGDLVVADSEIAADLGAETPEGFLPLEALGFPQLPGggrsyfnriPLDPDLVERAVQLAR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351 151 AGHLPHAVAPVLTVSTVTGTADRAAELAGRHpGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALE 230
Cdd:TIGR03664 134 ALGLPVARGPFLTVSTVSGTAARAEALARRF-GAVAENMEGAAVALAALRYGVPFLELRGISNLVGPRDRSRWRIKEALA 212


                  ....*....
gi 2769516351 231 SLRRAFELL 239
Cdd:TIGR03664 213 ALQRAAAKL 221
MtnN COG0775
Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine ...
 84-241 1.75e-14

Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB [Nucleotide transport and metabolism, Coenzyme transport and metabolism]; Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440538  Cd Length: 231  Bit Score: 70.32  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  84 LVVSAGIAGGFLPLAPLGSVVVSASVVAADLGARTPDayLTVEELGFGRSVHPVPDALTGRISAALTAGHLPHAVAPVLT 163
Cdd:COG0775    70 AVINTGVAGGLDPDLKIGDVVLATEVVQHDVDVTAFG--YPRGQVPGMPALFEADPALLEAAKEAAKESGLKVVTGTIAT 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351 164 VSTVTGTADRAAELAGRHPGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWR------IGDALESLRRAFE 237
Cdd:COG0775   148 GDRFVWSAEEKRRLRERFPGALAVDMEGAAIAQVCYRFGVPFLVIRAISDLAGEKAPNDFDefleeaAKNAAELLRALLR 227


                  ....
gi 2769516351 238 LLSS 241
Cdd:COG0775   228 KLRS 231
PNP_UDP_1 pfam01048
Phosphorylase superfamily; Members of this family include: purine nucleoside phosphorylase ...
 84-235 1.82e-04

Phosphorylase superfamily; Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)


Pssm-ID: 426013  Cd Length: 233  Bit Score: 41.56  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  84 LVVSAGIAGGFLPLAPLGSVVVSASVVAADLGArtpDAYLTVEELGFGRSVHPVPDA-LTGRISAALTAGHLPHAVAPVL 162
Cdd:pfam01048  72 AIIRTGTAGGLNPDLKVGDVVIPTDAINHDGRS---PLFGPEGGPYFPDMAPAPADPeLRALAKEAAERLGIPVHRGVYA 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769516351 163 TVSTVTGTADRAAELAgRHPGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALESLRRA 235
Cdd:pfam01048 149 TGDGFYFETPAEIRLL-RRLGADAVEMETAAEAQVAREAGIPFAAIRVVSDLAAGGADGELTHEEVEEFAERA 220
 
Name Accession Description Interval E-value
PRK08236 PRK08236
hypothetical protein; Provisional
 4-239 2.47e-59

hypothetical protein; Provisional


Pssm-ID: 236194  Cd Length: 212  Bit Score: 186.80  E-value: 2.47e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351   4 RSLIVTAVAAEADSVSAGLGphlggpvllplpgglvlrrhtaGPVRVDVLVGGVGPAAVAAATGTAltsaaLTDPDAPYG 83
Cdd:PRK08236    3 RVLVVTAVPAERDAVLRGLG----------------------NDSRFDVLAAGVGPAAAAASTARA-----LAAAAAPYD 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  84 LVVSAGIAGGFLPLAPLGSVVVSASVVAADLGARTPDAYLTVEELGFGRSVHPVPDALTGRISAALTAGHLPHAVAPVLT 163
Cdd:PRK08236   56 LVVSAGIAGGFPGKAEVGSLVVADEIIAADLGAETPDGFLPVDELGFGTTTIQVDPALVRQLTEALLAAALGATAGPVLT 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769516351 164 VSTVTGTADRAAELAGRHPGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALESLRRAFELL 239
Cdd:PRK08236  136 VSTVTGTAETAAALAARHPDAVAEAMEGFGVAEAAAAAGLPVLELRAISNPVGPRDRAAWRIKEALAALTAASSVL 211
futalosine_nucleosidase_MqnB cd17766
futalosine nucleosidase which catalyzes the hydrolysis of futalosine to ...
 80-239 8.81e-52

futalosine nucleosidase which catalyzes the hydrolysis of futalosine to dehypoxanthinylfutalosine and a hypoxanthine base; similar to Thermus thermophiles MqnB; Futalosine nucleosidase (MqnB, EC 3.2.2.26, also known as futalosine hydrolase) functions in an alternative menaquinone biosynthetic pathway (the futalosine pathway) which operates in some bacteria, including Streptomyces coelicolor and Thermus thermophiles. This domain model belongs to the PNP_UDP_1 superfamily which includes members which accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. PNP_UDP_1 includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Superfamily members have different physiologically relevant quaternary structures: hexameric such as the trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP, homotrimeric such as human PNP and Escherichia coli PNPII (XapA), homohexomeric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD), or homodimeric such as human and Trypanosoma brucei UP. The PNP_UDP_2 (nucleoside phosphorylase-II family) is a different structural family.


Pssm-ID: 350166  Cd Length: 217  Bit Score: 167.71  E-value: 8.81e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  80 APYGLVVSAGIAGGFLP-LAPLGSVVVSASVVAADLGARTPDAYLTVEELGFGRSVHPVPDALTGRISAALTAGHLPHAV 158
Cdd:cd17766    57 HPPDLVINAGIAGAFPGsGLSVGDLVVASEEIAADLGVETPEGFLSLDELGFGLLRIGTDPYLNRFPLSALLLAAGLQVK 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351 159 -APVLTVSTVTGTADRAAELAGRHPGAgAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALESLRRAFE 237
Cdd:cd17766   137 tGPFLTVSTVTGTAERAAELQRRFPAI-AENMEGAAVAHAALLYGVPFLEIRGISNPVGPRDRSAWDIPEALEALQRAVL 215


                  ..
gi 2769516351 238 LL 239
Cdd:cd17766   216 AL 217
fut_nucase TIGR03664
futalosine hydrolase; This enzyme catalyzes the conversion of futalosine to de-hypoxanthine ...
 80-239 6.87e-42

futalosine hydrolase; This enzyme catalyzes the conversion of futalosine to de-hypoxanthine futalosine in a pathway for the biosynthesis of menaquinone distinct from the pathway observed in E. coli.


Pssm-ID: 274710  Cd Length: 222  Bit Score: 142.44  E-value: 6.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  80 APYGLVVSAGIAGGFLPLAPLGSVVVSASVVAADLGARTPDAYLTVEELGFGRSVH---------PVPDALTGRISAALT 150
Cdd:TIGR03664  54 APYELVINAGIAGGFPGKAAVGDLVVADSEIAADLGAETPEGFLPLEALGFPQLPGggrsyfnriPLDPDLVERAVQLAR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351 151 AGHLPHAVAPVLTVSTVTGTADRAAELAGRHpGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALE 230
Cdd:TIGR03664 134 ALGLPVARGPFLTVSTVSGTAARAEALARRF-GAVAENMEGAAVALAALRYGVPFLELRGISNLVGPRDRSRWRIKEALA 212


                  ....*....
gi 2769516351 231 SLRRAFELL 239
Cdd:TIGR03664 213 ALQRAAAKL 221
MtnN COG0775
Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine ...
 84-241 1.75e-14

Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB [Nucleotide transport and metabolism, Coenzyme transport and metabolism]; Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440538  Cd Length: 231  Bit Score: 70.32  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  84 LVVSAGIAGGFLPLAPLGSVVVSASVVAADLGARTPDayLTVEELGFGRSVHPVPDALTGRISAALTAGHLPHAVAPVLT 163
Cdd:COG0775    70 AVINTGVAGGLDPDLKIGDVVLATEVVQHDVDVTAFG--YPRGQVPGMPALFEADPALLEAAKEAAKESGLKVVTGTIAT 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351 164 VSTVTGTADRAAELAGRHPGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWR------IGDALESLRRAFE 237
Cdd:COG0775   148 GDRFVWSAEEKRRLRERFPGALAVDMEGAAIAQVCYRFGVPFLVIRAISDLAGEKAPNDFDefleeaAKNAAELLRALLR 227


                  ....
gi 2769516351 238 LLSS 241
Cdd:COG0775   228 KLRS 231
NP_MTAN-like cd17877
nucleoside phosphorylases similar to 5'-methylthioadenosine/S-adenosylhomocysteine ...
 161-214 3.25e-06

nucleoside phosphorylases similar to 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases; This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs), as well as futalosine nucleosidase and adenosylhopane nucleosidase. Bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.


Pssm-ID: 350170 [Multi-domain]  Cd Length: 210  Bit Score: 46.52  E-value: 3.25e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2769516351 161 VLTVSTVTGTADRAAELAGRHPgAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNA 214
Cdd:cd17877   130 IITVDAIVRKSAEKAALAARFP-ALAVDMESAAIAQVAAARGIPFLAIRAISDP 182
PNP_UDP_1 pfam01048
Phosphorylase superfamily; Members of this family include: purine nucleoside phosphorylase ...
 84-235 1.82e-04

Phosphorylase superfamily; Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)


Pssm-ID: 426013  Cd Length: 233  Bit Score: 41.56  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769516351  84 LVVSAGIAGGFLPLAPLGSVVVSASVVAADLGArtpDAYLTVEELGFGRSVHPVPDA-LTGRISAALTAGHLPHAVAPVL 162
Cdd:pfam01048  72 AIIRTGTAGGLNPDLKVGDVVIPTDAINHDGRS---PLFGPEGGPYFPDMAPAPADPeLRALAKEAAERLGIPVHRGVYA 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769516351 163 TVSTVTGTADRAAELAgRHPGAGAEAMEGFGVAEAAAAHGLPVVEIRAVSNAVGPRDRAAWRIGDALESLRRA 235
Cdd:pfam01048 149 TGDGFYFETPAEIRLL-RRLGADAVEMETAAEAQVAREAGIPFAAIRVVSDLAAGGADGELTHEEVEEFAERA 220
MTAN cd09008
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases; This subfamily includes both ...
 170-217 8.82e-03

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases; This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.


Pssm-ID: 350159  Cd Length: 222  Bit Score: 36.32  E-value: 8.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2769516351 170 TADRAAELAGRHPGAGAEaMEGFGVAEAAAAHGLPVVEIRAVSNAVGP 217
Cdd:cd09008   152 SSEKKEELRENFPALAVE-MEGAAIAQVCYLNGVPFLVIRSISDLADG 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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