NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2752086961|ref|WP_353501548|]
View 

3-phosphoshikimate 1-carboxyvinyltransferase [Ewingella sp. CoE-038-23]

Protein Classification

3-phosphoshikimate 1-carboxyvinyltransferase( domain architecture ID 11414790)

3-phosphoshikimate 1- carboxyvinyltransferase catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; 3-phosphoshikimate 1-carboxyvinyltransferase catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate

EC:  2.5.1.19
Gene Ontology:  GO:0009073|GO:0008652|GO:0003866|GO:0009423
PubMed:  8973316|17348837
SCOP:  4001425

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-423 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 439898  Cd Length: 421  Bit Score: 616.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSaDRTHCDIDGLGG 80
Cdd:COG0128     1 MSSLTIAPPSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIEEL-DGGTLRVTGVGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFQPSEAlELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEqEDYPPVRLRGG-FKG 159
Cdd:COG0128    80 GLKEPDA-VLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRG-GGYLPLTIRGGpLKG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 160 GEVTVDGSVSSQFLTALLMTAPLAAADTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVsPGTYLV 239
Cdd:COG0128   158 GEYEIPGSASSQFKSALLLAGPLAEGGLEITVTGELESKPYRDHTERMLRAFGVEVEVEGYRRFTVPGGQRYR-PGDYTV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 240 EGDASSASYFLAAAAIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSRGSLTGIDMDMNHIPDAAMTIA 319
Cdd:COG0128   237 PGDISSAAFFLAAAAITGSEVTVEGVGLNSTQGDTGILDILKEMGADIEIENDGITVRGSPLKGIDIDLSDIPDEAPTLA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 320 TTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLTFAEIGTYNDHRMAMCFSLVALSNT 399
Cdd:COG0128   317 VLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRIAMAFAVAGLRAE 396

                         410       420
                  ....*....|....*....|....*
gi 2752086961 400 -PVTILDPKCTAKTFPDYFDRLAGI 423
Cdd:COG0128   397 gPVTIDDAECVAKSFPDFFELLESL 421
 
Name Accession Description Interval E-value
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-423 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439898  Cd Length: 421  Bit Score: 616.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSaDRTHCDIDGLGG 80
Cdd:COG0128     1 MSSLTIAPPSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIEEL-DGGTLRVTGVGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFQPSEAlELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEqEDYPPVRLRGG-FKG 159
Cdd:COG0128    80 GLKEPDA-VLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRG-GGYLPLTIRGGpLKG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 160 GEVTVDGSVSSQFLTALLMTAPLAAADTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVsPGTYLV 239
Cdd:COG0128   158 GEYEIPGSASSQFKSALLLAGPLAEGGLEITVTGELESKPYRDHTERMLRAFGVEVEVEGYRRFTVPGGQRYR-PGDYTV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 240 EGDASSASYFLAAAAIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSRGSLTGIDMDMNHIPDAAMTIA 319
Cdd:COG0128   237 PGDISSAAFFLAAAAITGSEVTVEGVGLNSTQGDTGILDILKEMGADIEIENDGITVRGSPLKGIDIDLSDIPDEAPTLA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 320 TTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLTFAEIGTYNDHRMAMCFSLVALSNT 399
Cdd:COG0128   317 VLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRIAMAFAVAGLRAE 396

                         410       420
                  ....*....|....*....|....*
gi 2752086961 400 -PVTILDPKCTAKTFPDYFDRLAGI 423
Cdd:COG0128   397 gPVTIDDAECVAKSFPDFFELLESL 421
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
1-424 0e+00

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 610.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRTHcdIDGLGG 80
Cdd:PRK11860    4 TEFLDLPPLLSAGGTVRLPGSKSISNRVLLLAALSEGTTTVRDLLDSDDTRVMLDALRALGCGVEQLGDTYR--ITGLGG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFqPSEALELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGG-FKG 159
Cdd:PRK11860   82 QF-PVKQADLFLGNAGTAMRPLTAALALLGGEYELSGVPRMHERPIGDLVDALRQLGCDIDYLGNEGFPPLRIGPApLRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 160 GE-VTVDGSVSSQFLTALLMTAPLAAA-DTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPGTY 237
Cdd:PRK11860  161 DApIRVRGDVSSQFLTALLMALPLVARrDITIEVVGELISKPYIEITLNLLARFGIAVQREGWQRFTIPAGSRYRSPGEI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 238 LVEGDASSASYFLAAAAIKGGT-VRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSRGS--LTGIDMDMNHIPDA 314
Cdd:PRK11860  241 HVEGDASSASYFIAAGAIAGGApVRIEGVGRDSIQGDIRFAEAARAMGAQVTSGPNWLEVRRGAwpLKAIDLDCNHIPDA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 315 AMTIATTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQS---LTFAEIGTYNDHRMAMCF 391
Cdd:PRK11860  321 AMTLAVMALYADGTTTLRNIASWRVKETDRIAAMATELRKLGATVEEGADYIRVTPPAQaadWKAAAIHTYDDHRMAMCF 400

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2752086961 392 SLVAL--SNTPVTILDPKCTAKTFPDYFDRLAGIS 424
Cdd:PRK11860  401 SLAAFnpAGLPVRINDPKCVAKTFPDYFEALFSVA 435
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 12-423 0e+00

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 557.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  12 VNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRthCDIDGLGGAFQPSEAlELF 91
Cdd:cd01556     1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGT--VEIVGGGGLGLPPEA-VLD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  92 LGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGFKGGEVTVDGSVSSQ 171
Cdd:cd01556    78 CGNSGTTMRLLTGLLALQGGDSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPLIGGGGLKGGEVEIPGAVSSQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 172 FLTALLMTAPLAAADTTIRIkGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPgTYLVEGDASSASYFLA 251
Cdd:cd01556   158 FKSALLLAAPLAEGPTTIII-GELESKPYIDHTERMLRAFGAEVEVDGYRTITVKGGQKYKGP-EYTVEGDASSAAFFLA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 252 AAAIKGGTVRVTGIGKNSmqGDIRFADVLEKMGAKITW-AEDYIECSR-GSLTGIDMDMNHIPDAAMTIATTALFAQGPT 329
Cdd:cd01556   236 AAAITGSEIVIKNVGLNS--GDTGIIDVLKEMGADIEIgNEDTVVVESgGKLKGIDIDGNDIPDEAPTLAVLAAFAEGPT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 330 TLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEP-PQSLTFAEIGTYNDHRMAMCFSLVAL-SNTPVTILDPK 407
Cdd:cd01556   314 RIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGgPLKGAGVEVYTYGDHRIAMSFAIAGLvAEGGVTIEDPE 393

                         410
                  ....*....|....*.
gi 2752086961 408 CTAKTFPDYFDRLAGI 423
Cdd:cd01556   394 CVAKSFPNFFEDLESL 409
aroA TIGR01356
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ...
 14-423 4.40e-168

3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273574  Cd Length: 409  Bit Score: 477.54  E-value: 4.40e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  14 GTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRTHcdIDGLGGAFqPSEalELFLG 93
Cdd:TIGR01356   1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAV--IEGVGGKE-PQA--ELDLG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  94 NAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGFKGGEVTVDGSVSSQFL 173
Cdd:TIGR01356  76 NSGTTARLLTGVLALADGEVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 174 TALLMTAPLAAADTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPGtYLVEGDASSASYFLAAA 253
Cdd:TIGR01356 156 SALLLAAPALQAVGITIVGEPLKSRPYIEITLDLLGSFGVEVERSDGRKIVVPGGQKYGPQG-YDVPGDYSSAAFFLAAA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 254 AIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIEC-SRGSLTGIDMDMNHIPDAAMTIATTALFAQGPTTLR 332
Cdd:TIGR01356 235 AITGGRVTLENLGINPTQGDKAIIIVLEEMGADIEVEEDDLIVeGASGLKGIKIDMDDMIDELPTLAVLAAFAEGVTRIT 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 333 NIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLTFAEIGTYNDHRMAMCFSLVALSN-TPVTILDPKCTAK 411
Cdd:TIGR01356 315 GAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELKGAVVDTFGDHRIAMAFAVAGLVAeGEVLIDDPECVAK 394

                         410
                  ....*....|..
gi 2752086961 412 TFPDYFDRLAGI 423
Cdd:TIGR01356 395 SFPSFFDVLERL 406
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
7-420 1.06e-162

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 464.08  E-value: 1.06e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   7 QPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVT-HRLSADRTHCDIDGLGGAFQPS 85
Cdd:pfam00275   1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEiIKLDDEKSVVIVEGLGGSFEAP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  86 EALELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGfKGGEVTVD 165
Cdd:pfam00275  81 EDLVLDMGNSGTALRPLTGRLALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGL-RLGGIHID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 166 GSVSSQFLTALLMTAPLAAADTTIrIKGdLVSKPYIDITLNLMKTFGVTVENQNY-QEFRIKGQQtyVSPGT-YLVEGDA 243
Cdd:pfam00275 160 GDVSSQFVTSLLMLAALLAEGTTT-IEN-LASEPYIDDTENMLKKFGAKIEGSGTeLSITVKGGE--KLPGQeYRVEGDR 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 244 SSASYFLAAAAIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSRGS-LTGIDMDMNHIPDAAMTIATTA 322
Cdd:pfam00275 236 SSAAYFLVAAAITGGTVTVENVGINSLQGDEALLEILEKMGAEITQEEDADIVVGPPgLRGKAVDIRTAPDPAPTTAVLA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 323 LFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPP-QSLTFAEIGTYNDHRMAMCFSLVAL-SNTP 400
Cdd:pfam00275 316 AFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIPAvKELKGAEVDSYGDHRIAMALALAGLvAEGE 395

                         410       420
                  ....*....|....*....|
gi 2752086961 401 VTILDPKCTAKTFPDYFDRL 420
Cdd:pfam00275 396 TIIDDIECTDRSFPDFEEKL 415
 
Name Accession Description Interval E-value
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-423 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439898  Cd Length: 421  Bit Score: 616.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSaDRTHCDIDGLGG 80
Cdd:COG0128     1 MSSLTIAPPSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIEEL-DGGTLRVTGVGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFQPSEAlELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEqEDYPPVRLRGG-FKG 159
Cdd:COG0128    80 GLKEPDA-VLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRG-GGYLPLTIRGGpLKG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 160 GEVTVDGSVSSQFLTALLMTAPLAAADTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVsPGTYLV 239
Cdd:COG0128   158 GEYEIPGSASSQFKSALLLAGPLAEGGLEITVTGELESKPYRDHTERMLRAFGVEVEVEGYRRFTVPGGQRYR-PGDYTV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 240 EGDASSASYFLAAAAIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSRGSLTGIDMDMNHIPDAAMTIA 319
Cdd:COG0128   237 PGDISSAAFFLAAAAITGSEVTVEGVGLNSTQGDTGILDILKEMGADIEIENDGITVRGSPLKGIDIDLSDIPDEAPTLA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 320 TTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLTFAEIGTYNDHRMAMCFSLVALSNT 399
Cdd:COG0128   317 VLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRIAMAFAVAGLRAE 396

                         410       420
                  ....*....|....*....|....*
gi 2752086961 400 -PVTILDPKCTAKTFPDYFDRLAGI 423
Cdd:COG0128   397 gPVTIDDAECVAKSFPDFFELLESL 421
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
1-424 0e+00

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 610.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRTHcdIDGLGG 80
Cdd:PRK11860    4 TEFLDLPPLLSAGGTVRLPGSKSISNRVLLLAALSEGTTTVRDLLDSDDTRVMLDALRALGCGVEQLGDTYR--ITGLGG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFqPSEALELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGG-FKG 159
Cdd:PRK11860   82 QF-PVKQADLFLGNAGTAMRPLTAALALLGGEYELSGVPRMHERPIGDLVDALRQLGCDIDYLGNEGFPPLRIGPApLRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 160 GE-VTVDGSVSSQFLTALLMTAPLAAA-DTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPGTY 237
Cdd:PRK11860  161 DApIRVRGDVSSQFLTALLMALPLVARrDITIEVVGELISKPYIEITLNLLARFGIAVQREGWQRFTIPAGSRYRSPGEI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 238 LVEGDASSASYFLAAAAIKGGT-VRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSRGS--LTGIDMDMNHIPDA 314
Cdd:PRK11860  241 HVEGDASSASYFIAAGAIAGGApVRIEGVGRDSIQGDIRFAEAARAMGAQVTSGPNWLEVRRGAwpLKAIDLDCNHIPDA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 315 AMTIATTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQS---LTFAEIGTYNDHRMAMCF 391
Cdd:PRK11860  321 AMTLAVMALYADGTTTLRNIASWRVKETDRIAAMATELRKLGATVEEGADYIRVTPPAQaadWKAAAIHTYDDHRMAMCF 400

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2752086961 392 SLVAL--SNTPVTILDPKCTAKTFPDYFDRLAGIS 424
Cdd:PRK11860  401 SLAAFnpAGLPVRINDPKCVAKTFPDYFEALFSVA 435
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-424 0e+00

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 597.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVthrlSADRTHCDIDGLGG 80
Cdd:PRK02427    2 MMMLLIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGV----EIEDDEVVVEGVGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFQPSEALELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYlEQEDYPPVRLRGGFKGG 160
Cdd:PRK02427   78 GGLKEPEDVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQMGAKIEG-RDEGYLPLTIRGGKKGG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 161 EVTVDGSVSSQFLTALLMTAPLAAA-DTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQ---NYQEFRIKGQQTYVsPGT 236
Cdd:PRK02427  157 PIEYDGPVSSQFVKSLLLLAPLFAEgDTETTVIEPLPSRPHTEITLRMLRAFGVEVENVegwGYRRIVIKGGQRLR-GQD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 237 YLVEGDASSASYFLAAAAIKGG-TVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDY--------IECSRGSLTGIDMD 307
Cdd:PRK02427  236 ITVPGDPSSAAFFLAAAAITGGsEVTITNVGLNSTQGGKAIIDVLEKMGADIEIENEReggepvgdIRVRSSELKGIDID 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 308 MNHIPDAAMTIATTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLtfAEIGTYNDHRM 387
Cdd:PRK02427  316 IPDIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGGPLA--GVVDSYGDHRI 393

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2752086961 388 AMCFSLVALSNT-PVTILDPKCTAKTFPDYFDRLAGIS 424
Cdd:PRK02427  394 AMAFAIAGLAAEgPVTIDDPECVAKSFPDFFEDLASLG 431
PLN02338 PLN02338
3-phosphoshikimate 1-carboxyvinyltransferase
 1-425 0e+00

3-phosphoshikimate 1-carboxyvinyltransferase


Pssm-ID: 177972 [Multi-domain]  Cd Length: 443  Bit Score: 562.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRTHCDIDGLGG 80
Cdd:PLN02338    1 AEEITLQPIKEISGTVKLPGSKSLSNRILLLAALSEGTTVVDNLLDSDDIRYMLGALKTLGLNVEEDSENNRAVVEGCGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AF----QPSEALELFLGNAGTAMRPLAAALCLGAHDV--VLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRL- 153
Cdd:PLN02338   81 KFpvsgDSKEDVELFLGNAGTAMRPLTAAVTAAGGNAsyVLDGVPRMRERPIGDLVDGLKQLGADVECTLGTNCPPVRVn 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 154 -RGGFKGGEVTVDGSVSSQFLTALLMTAPLAAADTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQN-YQEFRIKGQQTY 231
Cdd:PLN02338  161 aAGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSVEHSDsWDRFFIKGGQKY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 232 VSPGTYLVEGDASSASYFLAAAAIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSR--------GSLTG 303
Cdd:PLN02338  241 KSPGNAYVEGDASSASYFLAGAAITGGTVTVEGCGTTSLQGDVKFAEVLEKMGAKVEWTENSVTVTGpprdafggKHLKA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 304 IDMDMNHIPDAAMTIATTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLTFAEIGTYN 383
Cdd:PLN02338  321 IDVNMNKMPDVAMTLAVVALFADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCIITPPKKLKPAEIDTYD 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2752086961 384 DHRMAMCFSLVALSNTPVTILDPKCTAKTFPDYFDRLAGIST 425
Cdd:PLN02338  401 DHRMAMAFSLAACGDVPVTINDPGCTRKTFPTYFDVLESIAK 442
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 12-423 0e+00

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 557.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  12 VNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRthCDIDGLGGAFQPSEAlELF 91
Cdd:cd01556     1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGT--VEIVGGGGLGLPPEA-VLD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  92 LGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGFKGGEVTVDGSVSSQ 171
Cdd:cd01556    78 CGNSGTTMRLLTGLLALQGGDSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPLIGGGGLKGGEVEIPGAVSSQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 172 FLTALLMTAPLAAADTTIRIkGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPgTYLVEGDASSASYFLA 251
Cdd:cd01556   158 FKSALLLAAPLAEGPTTIII-GELESKPYIDHTERMLRAFGAEVEVDGYRTITVKGGQKYKGP-EYTVEGDASSAAFFLA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 252 AAAIKGGTVRVTGIGKNSmqGDIRFADVLEKMGAKITW-AEDYIECSR-GSLTGIDMDMNHIPDAAMTIATTALFAQGPT 329
Cdd:cd01556   236 AAAITGSEIVIKNVGLNS--GDTGIIDVLKEMGADIEIgNEDTVVVESgGKLKGIDIDGNDIPDEAPTLAVLAAFAEGPT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 330 TLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEP-PQSLTFAEIGTYNDHRMAMCFSLVAL-SNTPVTILDPK 407
Cdd:cd01556   314 RIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGgPLKGAGVEVYTYGDHRIAMSFAIAGLvAEGGVTIEDPE 393

                         410
                  ....*....|....*.
gi 2752086961 408 CTAKTFPDYFDRLAGI 423
Cdd:cd01556   394 CVAKSFPNFFEDLESL 409
EPT-like cd01554
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine ...
 12-423 7.14e-180

Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer.


Pssm-ID: 238795  Cd Length: 408  Bit Score: 507.53  E-value: 7.14e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  12 VNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRthCDIDGLGGAFQPSEALELF 91
Cdd:cd01554     1 LHGIIRVPGDKSISHRSLIFASLAEGETKVYNILRGEDVLSTMQVLRDLGVEIEDKDGV--ITIQGVGMAGLKAPQNALN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  92 LGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGFKGGEVTVDGSVSSQ 171
Cdd:cd01554    79 LGNSGTAIRLISGVLAGADFEVELFGDDSLSKRPMDRVTLPLKKMGASISGQEERDLPPLLKGGKNLGPIHYEDPIASAQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 172 FLTALLMTAPLAAADTTIRIKgdlVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPgTYLVEGDASSASYFLA 251
Cdd:cd01554   159 VKSALMFAALLAKGETVIIEA---AKEPTINHTENMLQTFGGHISVQGTKKIVVQGPQKLTGQ-KYVVPGDISSAAFFLV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 252 AAAIKGGTVRVTGIGKNSmqGDIRFADVLEKMGAKITWAEDYIECSRGSLTGIDMDMNHIP---DAAMTIATTALFAQGP 328
Cdd:cd01554   235 AAAIAPGRLVLQNVGINE--TRTGIIDVLRAMGAKIEIGEDTISVESSDLKATEICGALIPrliDELPIIALLALQAQGT 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 329 TTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLTFAEIGTYNDHRMAMCFSLVAL-SNTPVTILDPK 407
Cdd:cd01554   313 TVIKDAEELKVKETDRIFVVADELNSMGADIEPTADGMIIKGKEKLHGARVNTFGDHRIGMMTALAALvADGEVELDRAE 392

                         410
                  ....*....|....*.
gi 2752086961 408 CTAKTFPDYFDRLAGI 423
Cdd:cd01554   393 AINTSYPSFFDDLESL 408
aroA TIGR01356
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ...
 14-423 4.40e-168

3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273574  Cd Length: 409  Bit Score: 477.54  E-value: 4.40e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  14 GTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRTHcdIDGLGGAFqPSEalELFLG 93
Cdd:TIGR01356   1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAV--IEGVGGKE-PQA--ELDLG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  94 NAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGFKGGEVTVDGSVSSQFL 173
Cdd:TIGR01356  76 NSGTTARLLTGVLALADGEVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 174 TALLMTAPLAAADTTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPGtYLVEGDASSASYFLAAA 253
Cdd:TIGR01356 156 SALLLAAPALQAVGITIVGEPLKSRPYIEITLDLLGSFGVEVERSDGRKIVVPGGQKYGPQG-YDVPGDYSSAAFFLAAA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 254 AIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIEC-SRGSLTGIDMDMNHIPDAAMTIATTALFAQGPTTLR 332
Cdd:TIGR01356 235 AITGGRVTLENLGINPTQGDKAIIIVLEEMGADIEVEEDDLIVeGASGLKGIKIDMDDMIDELPTLAVLAAFAEGVTRIT 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 333 NIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLTFAEIGTYNDHRMAMCFSLVALSN-TPVTILDPKCTAK 411
Cdd:TIGR01356 315 GAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELKGAVVDTFGDHRIAMAFAVAGLVAeGEVLIDDPECVAK 394

                         410
                  ....*....|..
gi 2752086961 412 TFPDYFDRLAGI 423
Cdd:TIGR01356 395 SFPSFFDVLERL 406
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
7-420 1.06e-162

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 464.08  E-value: 1.06e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   7 QPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVT-HRLSADRTHCDIDGLGGAFQPS 85
Cdd:pfam00275   1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEiIKLDDEKSVVIVEGLGGSFEAP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  86 EALELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGfKGGEVTVD 165
Cdd:pfam00275  81 EDLVLDMGNSGTALRPLTGRLALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGL-RLGGIHID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 166 GSVSSQFLTALLMTAPLAAADTTIrIKGdLVSKPYIDITLNLMKTFGVTVENQNY-QEFRIKGQQtyVSPGT-YLVEGDA 243
Cdd:pfam00275 160 GDVSSQFVTSLLMLAALLAEGTTT-IEN-LASEPYIDDTENMLKKFGAKIEGSGTeLSITVKGGE--KLPGQeYRVEGDR 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 244 SSASYFLAAAAIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIECSRGS-LTGIDMDMNHIPDAAMTIATTA 322
Cdd:pfam00275 236 SSAAYFLVAAAITGGTVTVENVGINSLQGDEALLEILEKMGAEITQEEDADIVVGPPgLRGKAVDIRTAPDPAPTTAVLA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 323 LFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPP-QSLTFAEIGTYNDHRMAMCFSLVAL-SNTP 400
Cdd:pfam00275 316 AFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIPAvKELKGAEVDSYGDHRIAMALALAGLvAEGE 395

                         410       420
                  ....*....|....*....|
gi 2752086961 401 VTILDPKCTAKTFPDYFDRL 420
Cdd:pfam00275 396 TIIDDIECTDRSFPDFEEKL 415
PRK11861 PRK11861
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-424 1.12e-158

bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 183343 [Multi-domain]  Cd Length: 673  Bit Score: 463.41  E-value: 1.12e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   1 MESLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVthRLSADRTHCDIDGLGG 80
Cdd:PRK11861  240 MEHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGV--KLSRDGGTCVVGGTRG 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFQPSEAlELFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEYLEQEDYPPVRLRGGFKG- 159
Cdd:PRK11861  318 AFTAKTA-DLFLGNAGTAVRPLTAALAVNGGEYRIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATISv 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 160 -GEVTVDGSVSSQFLTALLMTAPLAAAD---TTIRIKGDLVSKPYIDITLNLMKTFGVTVENQNYQEFRIKGQQTYVSPG 235
Cdd:PRK11861  397 dAPIRVRGDVSSQFLTALLMTLPLVKAKdgaSVVEIDGELISKPYIEITIKLMARFGVTVERDGWQRFTVPAGVRYRSPG 476

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 236 TYLVEGDASSASYFLAAAAIKGGTVRVTGIGKNSMQGDIRFADVLEKMGAKITWAEDYIEC-----SRGSLTGIDMDMNH 310
Cdd:PRK11861  477 TIMVEGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIEVrgighDHGRLAPIDMDFNL 556

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 311 IPDAAMTIATTALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQSLT-FAEIGTYNDHRMAM 389
Cdd:PRK11861  557 IPDAAMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTpNASIDTYDDHRMAM 636

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2752086961 390 CFSLVALSNTPVTILDPKCTAKTFPDYFDRLAGIS 424
Cdd:PRK11861  637 CFSLVSLGGVPVRINDPKCVGKTFPDYFDRFLALA 671
EPT_RTPC-like cd01553
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate ...
 240-423 6.53e-52

This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a 4th slightly different domain inserted between the 2nd and 3rd repeat. They evidently share the same active site location, although the catalytic residues differ.


Pssm-ID: 238794  Cd Length: 211  Bit Score: 173.62  E-value: 6.53e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 240 EGDASSASYFLAAAAIKGGTVRVTGIGKNSM-----QGDIRFADVLEKM-GAKITWAE---DYIECSRGSLTGIDMDMNH 310
Cdd:cd01553     7 KGGGQILRSFLVLAAISGGPITVTGIRPDRAkpgllRQHLTFLKALEKIcGATVEGGElgsDRISFRPGTVRGGDVRFAI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 311 -----IPDAAMTIATTALFAQGPTTLRNIYNWRV----KETDRLAAMATELRKVGAIVEEGED------------YIRVE 369
Cdd:cd01553    87 gsagsCTDVLQTILPLLLFAKGPTRLTVTGGTDNpsapPADFIRFVLEPELAKIGAHQEETLLrhgfypagggvvATEVS 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2752086961 370 PPQSLTFAEIgtyndhRMAMCFSLVAlsnTPVTILDPKCTAKTFPDYFDRLAGI 423
Cdd:cd01553   167 PVEKLNTAQL------RQLVLPMLLA---SGAVEFTVAHPSCHLLTNFAVLEAL 211
PRK14806 PRK14806
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; ...
 3-421 2.87e-48

bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 237820 [Multi-domain]  Cd Length: 735  Bit Score: 175.57  E-value: 2.87e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961   3 SLTLQPVALVNGTINLPGSKSVSNRALLLAAFAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRlSADRTHCDIDGLG--G 80
Cdd:PRK14806  303 SYSVLPGGAVKGTIRVPGDKSISHRSIMLGSLAEGVTEVEGFLEGEDALATLQAFRDMGVVIE-GPHNGRVTIHGVGlhG 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  81 AFQPSEAleLFLGNAGTAMRPLAAALCLGAHDVVLTGEPRMKERPIGHLVDALRQGGAEIEyLEQEDYPPVRLRGGFKGG 160
Cdd:PRK14806  382 LKAPPGP--LYMGNSGTSMRLLSGLLAAQSFDSVLTGDASLSKRPMERVAKPLREMGAVIE-TGEEGRPPLSIRGGQRLK 458

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 161 EVTVDGSVSSQFLTALLMTAPLAAADTTIrikgdlVSKPYI--DITLNLMKTFGVTVEnqnyqefrIKGQQTYVSPGTYL 238
Cdd:PRK14806  459 GIHYDLPMASAQVKSCLLLAGLYAEGETS------VTEPAPtrDHTERMLRGFGYPVK--------VEGNTISVEGGGKL 524

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 239 ------VEGDASSASYFLAAAAIKGGT-VRVTGIGKNSMQgdIRFADVLEKMGAKITWAEDYI---EC-----SRGS-LT 302
Cdd:PRK14806  525 tatdieVPADISSAAFFLVAASIAEGSeLTLEHVGINPTR--TGVIDILKLMGADITLENEREvggEPvadirVRGArLK 602

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 303 GIDMDMNHIPDA-----AMTIAttALFAQGPTTLRNIYNWRVKETDRLAAMATELRKVGAIVEEGEDYIRVEPPQsLTFA 377
Cdd:PRK14806  603 GIDIPEDQVPLAidefpVLFVA--AACAEGRTVLTGAEELRVKESDRIQVMADGLKTLGIDCEPTPDGIIIEGGI-FGGG 679

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 2752086961 378 EIGTYNDHRMAMCFSLVAL-SNTPVTILDPKCTAKTFPDyFDRLA 421
Cdd:PRK14806  680 EVESHGDHRIAMSFSVASLrASGPITIHDCANVATSFPN-FLELA 723
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 13-379 3.47e-14

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 73.87  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  13 NGTINLPGSKsvsNRAL-LLAA--FAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRThCDIDGlgGAFQPSEA-L 88
Cdd:COG0766    13 SGEVRISGAK---NAALpILAAalLTDGPVTLRNVPDLSDVRTMLELLESLGVKVERDDGGT-LTIDA--SNINSTEApY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  89 ELflgnaGTAMRplAAALCLGAhdvvLTGepRMKE-------------RPIG-HLvDALRQGGAEIEylEQEDYppVRLR 154
Cdd:COG0766    87 EL-----VRKMR--ASILVLGP----LLA--RFGEarvslpggcaigaRPIDlHL-KGLEALGAEIE--IEHGY--IEAR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 155 -GGFKGGEVTVDG-SVssqflTA---LLMTAPLAAADTTIR-------IkGDLvskpyIDItLNLMktfGVTVENQNYQE 222
Cdd:COG0766   149 aGRLKGARIYLDFpSV-----GAtenIMMAAVLAEGTTVIEnaarepeI-VDL-----ANF-LNAM---GAKIEGAGTDT 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 223 FRIKGqqtyV---SPGTYLVEGD---ASSasyFLAAAAIKGGTVRVTGIGKNSMQGdirFADVLEKMGAKITWAEDYIE- 295
Cdd:COG0766   214 ITIEG----VeklHGAEHTVIPDrieAGT---FLVAAAITGGDVTVKNVIPEHLEA---VLAKLREAGVEIEEGDDGIRv 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 296 CSRGSLTGIDM----------DMNHIpdaAMTIATTalfAQGPTTLR-NIYNWRVKETDrlaamatELRKVGA-IVEEGe 363
Cdd:COG0766   284 RGPGRLKAVDIktapypgfptDLQAQ---FMALLTQ---AEGTSVITeTVFENRFMHVD-------ELNRMGAdIKLDG- 349

                         410
                  ....*....|....*.
gi 2752086961 364 DYIRVEPPQSLTFAEI 379
Cdd:COG0766   350 HTAIVRGVTKLSGAPV 365
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 13-305 1.83e-10

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 62.36  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  13 NGTINLPGSKsvsNRAL-LLAA--FAQGTTRLNNLLDSDDVRHMLNALTKLGVTHRLSADRT-HCDIDGLGGAFQPSEAl 88
Cdd:PRK09369   13 SGEVTISGAK---NAALpILAAslLAEEPVTLTNVPDLSDVRTMIELLRSLGAKVEFDGNGTvTIDASNINNTEAPYEL- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961  89 elflgnAGTaMRplAAALCLGAhdvvLTGepRMKE-------------RPIG-HLvDALRQGGAEIEylEQEDYPPVRLR 154
Cdd:PRK09369   89 ------VKK-MR--ASILVLGP----LLA--RFGEakvslpggcaigaRPVDlHL-KGLEALGAEIE--IEHGYVEAKAD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 155 GGFKGGEVTVDG-SVssqflTA---LLMTAPLAAADTTIRikgDLVSKPYI-DIT--LNLMktfGVTVENQNYQEFRIKG 227
Cdd:PRK09369  151 GRLKGAHIVLDFpSV-----GAtenILMAAVLAEGTTVIE---NAAREPEIvDLAnfLNKM---GAKISGAGTDTITIEG 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2752086961 228 QQTyVSPGTYLVEGDASSASYFLAAAAIKGGTVRVTGIGKNSMQGdirFADVLEKMGAKITWAEDYIE-CSRGSLTGID 305
Cdd:PRK09369  220 VER-LHGAEHTVIPDRIEAGTFLVAAAITGGDVTIRGARPEHLEA---VLAKLREAGAEIEEGEDGIRvDMPGRLKAVD 294
UdpNAET cd01555
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ...
 160-369 9.00e-06

UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.


Pssm-ID: 238796  Cd Length: 400  Bit Score: 47.47  E-value: 9.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 160 GEVTVDGSVSSqfLTALLMTAPLAaaDTTIRIKG--DLVSkpyIDITLNLMKTFGVTVENQNYQEFRI--KGQQTYVSPG 235
Cdd:cd01555     3 GEVRISGAKNA--ALPILAAALLT--DEPVTLRNvpDLLD---VETMIELLRSLGAKVEFEGENTLVIdaSNINSTEAPY 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 236 TYlvegdASS--ASYFLAAAAI-KGGTVRVTG-----IGKnsmqgdiRFAD----VLEKMGAKITWAEDYIECSR-GSLT 302
Cdd:cd01555    76 EL-----VRKmrASILVLGPLLaRFGEARVSLpggcaIGA-------RPVDlhlkGLEALGAKIEIEDGYVEAKAaGRLK 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2752086961 303 G--IDMDMnhiPD--AAMTIATTALFAQGPTTLRNIYnwRVKETDRLAAMateLRKVGAIVE-EGEDYIRVE 369
Cdd:cd01555   144 GarIYLDF---PSvgATENIMMAAVLAEGTTVIENAA--REPEIVDLANF---LNKMGAKIEgAGTDTIRIE 207
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 278-382 1.31e-05

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 47.29  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 278 DVLEKMGAKITWAEDYIECSRGSLTG--IDMDM-------NhipdaAMTIATtalFAQGPTTLRNIYnwrvKE---TDrL 345
Cdd:COG0766   129 KGLEALGAEIEIEHGYIEARAGRLKGarIYLDFpsvgateN-----IMMAAV---LAEGTTVIENAA----REpeiVD-L 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2752086961 346 AAMateLRKVGAIVE-EGEDYIRVEPPQSLTFA---------EIGTY 382
Cdd:COG0766   196 ANF---LNAMGAKIEgAGTDTITIEGVEKLHGAehtvipdriEAGTF 239
PRK12830 PRK12830
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed
 246-379 1.18e-04

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed


Pssm-ID: 183779  Cd Length: 417  Bit Score: 44.08  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 246 ASYFLAAAAIKGGTVRVTGIGKNSMQGdirFADVLEKMGAKITWAEDYIE-CSRGSLTGIDMDMNHIP----DAAMTIAT 320
Cdd:PRK12830  235 AGTYMILAAACGGGVTINNVIPEHLES---FIAKLEEMGVRVEVNEDSIFvEKQGNLKAVDIKTLPYPgfatDLQQPLTP 311

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 321 TALFAQGPTTLR-NIYNWRVKETDrlaamatELRKVGAIVEEGEDYIRVEPPQSLTFAEI 379
Cdd:PRK12830  312 LLLKANGRSVVTdTIYEKRFKHVD-------ELKRMGANIKVEGRSAIITGPSKLTGAKV 364
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 280-382 3.13e-03

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 39.63  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752086961 280 LEKMGAKITWAEDYIECS-RGSLTG--IDMDMnhiPD--AAMTIATTALFAQGPTTLRNiynwrvketdrlAAMATE--- 351
Cdd:PRK09369  131 LEALGAEIEIEHGYVEAKaDGRLKGahIVLDF---PSvgATENILMAAVLAEGTTVIEN------------AAREPEivd 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2752086961 352 ----LRKVGAIVE-EGEDYIRVEPPQSLTFA---------EIGTY 382
Cdd:PRK09369  196 lanfLNKMGAKISgAGTDTITIEGVERLHGAehtvipdriEAGTF 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH