type III toxin-antitoxin system toxin TenpN and similar proteins; TenpN-like toxin component ...
3-127
7.41e-13
type III toxin-antitoxin system toxin TenpN and similar proteins; TenpN-like toxin component of a type III toxin-antitoxin (TA) system, which consists of a ribonuclease (RNase) toxin that processes its structured and specific cognate RNA antitoxin, which in turn then directly inhibits the toxin. TA systems have been associated with many important phenotypes, like phage resistance, maintenance of genomic islands, and formation of bacterial persister cells.
The actual alignment was detected with superfamily member cd17493:
Pssm-ID: 341213 Cd Length: 121 Bit Score: 65.67 E-value: 7.41e-13
type III toxin-antitoxin system toxin TenpN and similar proteins; TenpN-like toxin component ...
3-127
7.41e-13
type III toxin-antitoxin system toxin TenpN and similar proteins; TenpN-like toxin component of a type III toxin-antitoxin (TA) system, which consists of a ribonuclease (RNase) toxin that processes its structured and specific cognate RNA antitoxin, which in turn then directly inhibits the toxin. TA systems have been associated with many important phenotypes, like phage resistance, maintenance of genomic islands, and formation of bacterial persister cells.
Pssm-ID: 341213 Cd Length: 121 Bit Score: 65.67 E-value: 7.41e-13
N-terminal domain of anti-restriction factor ArdC; This is the ssDNA binding domain of ...
436-537
1.79e-06
N-terminal domain of anti-restriction factor ArdC; This is the ssDNA binding domain of anti-restriction factor ArdC deployed by plasmids and phages in polyvalent proteins related to the BHD domains of XPC/Rad4 and the Tc-38 domain found in kinetoplastid minicircle binding proteins. The structure of this domain is composed of three alpha-helices and a three-stranded beta-sheet that supports a long and protuberant beta-hairpin. This domain is also found in the N-terminal region of the RP4 TraC1 primase, together with the Toprim domain (pfam01751, pfam13362 and pfam13662).
Pssm-ID: 429975 Cd Length: 127 Bit Score: 47.72 E-value: 1.79e-06
type III toxin-antitoxin system toxin TenpN and similar proteins; TenpN-like toxin component ...
3-127
7.41e-13
type III toxin-antitoxin system toxin TenpN and similar proteins; TenpN-like toxin component of a type III toxin-antitoxin (TA) system, which consists of a ribonuclease (RNase) toxin that processes its structured and specific cognate RNA antitoxin, which in turn then directly inhibits the toxin. TA systems have been associated with many important phenotypes, like phage resistance, maintenance of genomic islands, and formation of bacterial persister cells.
Pssm-ID: 341213 Cd Length: 121 Bit Score: 65.67 E-value: 7.41e-13
N-terminal domain of anti-restriction factor ArdC; This is the ssDNA binding domain of ...
436-537
1.79e-06
N-terminal domain of anti-restriction factor ArdC; This is the ssDNA binding domain of anti-restriction factor ArdC deployed by plasmids and phages in polyvalent proteins related to the BHD domains of XPC/Rad4 and the Tc-38 domain found in kinetoplastid minicircle binding proteins. The structure of this domain is composed of three alpha-helices and a three-stranded beta-sheet that supports a long and protuberant beta-hairpin. This domain is also found in the N-terminal region of the RP4 TraC1 primase, together with the Toprim domain (pfam01751, pfam13362 and pfam13662).
Pssm-ID: 429975 Cd Length: 127 Bit Score: 47.72 E-value: 1.79e-06
Zincin-like metallopeptidase; Zincin-like Metallopeptidase frequently found in polyvalent ...
618-674
3.37e-06
Zincin-like metallopeptidase; Zincin-like Metallopeptidase frequently found in polyvalent proteins of phages and conjugative elements. The active site is comprised of a HEXXH motif and a C-terminal glutamate.
Pssm-ID: 465878 Cd Length: 126 Bit Score: 46.70 E-value: 3.37e-06
Putative metallopeptidase family (DUF6782); This family of proteins is functionally ...
584-659
8.28e-05
Putative metallopeptidase family (DUF6782); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 256 and 362 amino acids in length. There is a conserved HEXRH sequence motif which is characteriztic of metallopeptidase enzymes.
Pssm-ID: 466722 Cd Length: 241 Bit Score: 44.69 E-value: 8.28e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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