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Conserved domains on  [gi|2742304573|ref|WP_349356463|]
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family 16 glycosylhydrolase, partial [Streptococcus equi]

Protein Classification

BglS family protein( domain architecture ID 11455201)

BglS family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BglS COG2273
Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];
1-75 6.42e-16

Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];


:

Pssm-ID: 441874 [Multi-domain]  Cd Length: 259  Bit Score: 69.25  E-value: 6.42e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2742304573   1 MNWYPDKIEWYVDGIFYNTMYLTGDDrleaAAAAFNKPQYLQFNLATGGNWsknAGYYLASDETA-FVIDYVRYYQ 75
Cdd:COG2273   190 VEWTPDSIRWYVDGVLVHTVTPADVG----GPWPFDQPFYLILNLAVGGNW---PGAPDTTGFPAtMEVDYVRVYQ 258
 
Name Accession Description Interval E-value
BglS COG2273
Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];
1-75 6.42e-16

Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];


Pssm-ID: 441874 [Multi-domain]  Cd Length: 259  Bit Score: 69.25  E-value: 6.42e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2742304573   1 MNWYPDKIEWYVDGIFYNTMYLTGDDrleaAAAAFNKPQYLQFNLATGGNWsknAGYYLASDETA-FVIDYVRYYQ 75
Cdd:COG2273   190 VEWTPDSIRWYVDGVLVHTVTPADVG----GPWPFDQPFYLILNLAVGGNW---PGAPDTTGFPAtMEVDYVRVYQ 258
GH16_laminarinase_like cd08023
Laminarinase, member of the glycosyl hydrolase family 16; Laminarinase, also known as glucan ...
 1-74 8.64e-15

Laminarinase, member of the glycosyl hydrolase family 16; Laminarinase, also known as glucan endo-1,3-beta-D-glucosidase, is a glycosyl hydrolase family 16 member that hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans.


Pssm-ID: 185693 [Multi-domain]  Cd Length: 235  Bit Score: 66.11  E-value: 8.64e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2742304573   1 MNWYPDKIEWYVDGIFYNTMYLTGDDrlEAAAAAFNKPQYLQFNLATGGNWSKNAGyylasDETAF----VIDYVRYY 74
Cdd:cd08023   165 VEWTPDKITFYVDGKLYFTYTNPNTD--NGGQWPFDQPFYLILNLAVGGNWPGPPD-----DDTPFpatmEVDYVRVY 235
Glyco_hydro_16 pfam00722
Glycosyl hydrolases family 16;
3-72 7.29e-05

Glycosyl hydrolases family 16;


Pssm-ID: 395585 [Multi-domain]  Cd Length: 168  Bit Score: 38.73  E-value: 7.29e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2742304573   3 WYPDKIEWYVDGIFYNTMYltgddRLEAAAAAF-NKPQYLQFNLATGGNWSKNAGYYlasdetafVIDYVR 72
Cdd:pfam00722 111 WNPDKITWYVDGVPVRTLK-----NNDAGGVPYpQTPMRLYVSLWPGGDWATPGGGV--------KIDWAG 168
 
Name Accession Description Interval E-value
BglS COG2273
Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];
1-75 6.42e-16

Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];


Pssm-ID: 441874 [Multi-domain]  Cd Length: 259  Bit Score: 69.25  E-value: 6.42e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2742304573   1 MNWYPDKIEWYVDGIFYNTMYLTGDDrleaAAAAFNKPQYLQFNLATGGNWsknAGYYLASDETA-FVIDYVRYYQ 75
Cdd:COG2273   190 VEWTPDSIRWYVDGVLVHTVTPADVG----GPWPFDQPFYLILNLAVGGNW---PGAPDTTGFPAtMEVDYVRVYQ 258
GH16_laminarinase_like cd08023
Laminarinase, member of the glycosyl hydrolase family 16; Laminarinase, also known as glucan ...
 1-74 8.64e-15

Laminarinase, member of the glycosyl hydrolase family 16; Laminarinase, also known as glucan endo-1,3-beta-D-glucosidase, is a glycosyl hydrolase family 16 member that hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans.


Pssm-ID: 185693 [Multi-domain]  Cd Length: 235  Bit Score: 66.11  E-value: 8.64e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2742304573   1 MNWYPDKIEWYVDGIFYNTMYLTGDDrlEAAAAAFNKPQYLQFNLATGGNWSKNAGyylasDETAF----VIDYVRYY 74
Cdd:cd08023   165 VEWTPDKITFYVDGKLYFTYTNPNTD--NGGQWPFDQPFYLILNLAVGGNWPGPPD-----DDTPFpatmEVDYVRVY 235
GH16_Strep_laminarinase_like cd02182
Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Proteins similar to ...
 7-75 1.43e-07

Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Proteins similar to Streptomyces sioyaensis beta-1,3-glucanase (laminarinase) present in Actinomycetales as well as Peziomycotina. Laminarinases belong to glycosyl hydrolase family 16 and hydrolyze the glycosidic bond of the 1,3-beta-linked glucan, a major component of fungal and plant cell walls and the structural and storage polysaccharides (laminarin) of marine macro-algae. Members of the GH16 family have a conserved jelly roll fold with an active site channel.


Pssm-ID: 185691  Cd Length: 259  Bit Score: 46.54  E-value: 1.43e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2742304573   7 KIEWYVDGIFYNTmyLTGDDRLEAAA--AAFNKPQYLQFNLATGGNW-SKNAGYYLASDETAFVIDYVRYYQ 75
Cdd:cd02182   190 SIRWYLDGVVYHT--VTGARVGDETTwqALAHHPLFIILNVAVGGNWpGAPNGNTATGSGSAMEVDYVAVYS 259
Glyco_hydrolase_16 cd00413
glycosyl hydrolase family 16; The O-Glycosyl hydrolases are a widespread group of enzymes that ...
 1-74 1.60e-07

glycosyl hydrolase family 16; The O-Glycosyl hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycosyl hydrolase family 16. Family 16 includes lichenase, xyloglucan endotransglycosylase (XET), beta-agarase, kappa-carrageenase, endo-beta-1,3-glucanase, endo-beta-1,3-1,4-glucanase, and endo-beta-galactosidase, all of which have a conserved jelly roll fold with a deep active site channel harboring the catalytic residues.


Pssm-ID: 185683 [Multi-domain]  Cd Length: 210  Bit Score: 46.27  E-value: 1.60e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2742304573   1 MNWYPDKIEWYVDGIFYNTMYltgddrleaaAAAFNKPQYLQFNLATGGNWSKNAGYylASDETAFVIDYVRYY 74
Cdd:cd00413   149 VDWTPGEITFYVDGVLVATIT----------NQVPDDPMNIILNLWSDGGWWWGGPP--PGAPAYMEIDWVRVY 210
Glyco_hydro_16 pfam00722
Glycosyl hydrolases family 16;
3-72 7.29e-05

Glycosyl hydrolases family 16;


Pssm-ID: 395585 [Multi-domain]  Cd Length: 168  Bit Score: 38.73  E-value: 7.29e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2742304573   3 WYPDKIEWYVDGIFYNTMYltgddRLEAAAAAF-NKPQYLQFNLATGGNWSKNAGYYlasdetafVIDYVR 72
Cdd:pfam00722 111 WNPDKITWYVDGVPVRTLK-----NNDAGGVPYpQTPMRLYVSLWPGGDWATPGGGV--------KIDWAG 168
GH16_CCF cd08024
Coelomic cytolytic factor, member of glycosyl hydrolase family 16; Subgroup of glucanases of ...
 1-75 4.49e-03

Coelomic cytolytic factor, member of glycosyl hydrolase family 16; Subgroup of glucanases of unknown function that are related to beta-GRP (beta-1,3-glucan recognition protein), but contain active site residues. Beta-GRPs are one group of pattern recognition receptors (PRRs), also referred to as biosensor proteins, that complexes with pathogen-associated beta-1,3-glucans and then transduces signals necessary for activation of an appropriate innate immune response. Beta-GRPs are present in insects and lack all catalytic residues. This subgroup contains related proteins that still contain the active site and are widely distributed in eukaryotes. Their structures adopt a jelly roll fold with a deep active site channel harboring the catalytic residues, like those of other glycosyl hydrolase family 16 members.


Pssm-ID: 185694  Cd Length: 330  Bit Score: 33.76  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2742304573   1 MNWYPDKIEWYVDGIFYNTMYLTGDDRLEAA----------------AAAFNKPQYLQFNLATGGN-------------W 51
Cdd:cd08024   212 LDWTPDHIRFYVDDRLILTLDVPGQGFWEFGgfsgtpidnpwagggkMAPFDQEFYLILNVAVGGTngffpdgwpggkpW 291

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2742304573  52 SKNAGY-----YLA----------SDETAFVIDYVRYYQ 75
Cdd:cd08024   292 SNGSPTamrdfWEArnqwlptwhgGDDAAMQVDYVKMWQ 330
GH16_beta_GRP cd02179
beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16; Beta-GRP (beta-1, ...
 3-74 4.72e-03

beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16; Beta-GRP (beta-1,3-glucan recognition protein) is one of several pattern recognition receptors (PRRs), also referred to as biosensor proteins, that complexes with pathogen-associated beta-1,3-glucans and then transduces signals necessary for activation of an appropriate innate immune response. They are present in insects and lack all catalytic residues. This subgroup also contains related proteins of unknown function that still contain the active site. Their structures adopt a jelly roll fold with a deep active site channel harboring the catalytic residues, like those of other glycosyl hydrolase family 16 members.


Pssm-ID: 185688 [Multi-domain]  Cd Length: 321  Bit Score: 33.89  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2742304573   3 WYPDKIEWYVDGI-----------FYNTMYLTGDDRLEAAA--AAFNKPQYLQFNLATGGN--------------WsKNA 55
Cdd:cd02179   209 WKPDGITLMVDGEeygeiepgeggYSEAANNPAASRWLGGTvmAPFDKEFYLSLGVGVGGHndfpdssirgyvkpW-KNT 287

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2742304573  56 G------YYLA--------SDETAFVIDYVRYY 74
Cdd:cd02179   288 GpkamlkFWQArdkwfptwSDDSALKVDYVKVY 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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