|
Name |
Accession |
Description |
Interval |
E-value |
| EntE |
COG1021 |
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ... |
19-527 |
0e+00 |
|
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 796.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 19 WNGKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAH 98
Cdd:COG1021 22 WRGETLGDLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLALGLRPGDRVVVQLPNVAEFVIVFFALFRAGAI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 99 PVLLMPTQRAHDVHALCQIARPVAYIIPDCIHGFDYREMAREVAASCPELEHIIVDGEAEEFIPFASIEDEP--LNIIGP 176
Cdd:COG1021 102 PVFALPAHRRAEISHFAEQSEAVAYIIPDRHRGFDYRALARELQAEVPSLRHVLVVGDAGEFTSLDALLAAPadLSEPRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 177 GYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDTA 256
Cdd:COG1021 182 DPDDVAFFQLSGGTTGLPKLIPRTHDDYLYSVRASAEICGLDADTVYLAALPAAHNFPLSSPGVLGVLYAGGTVVLAPDP 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 257 SCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEGLLCY 335
Cdd:COG1021 262 SPDTAFPLIERERVTVTALVPPLALLWLDAAERSRYDLSSLRVLQVGGAKLSPELARRVRPALGCtLQQVFGMAEGLVNY 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 336 TRLDDPYEVIINTQGRPLSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRP 415
Cdd:COG1021 342 TRLDDPEEVILTTQGRPISPDDEVRIVDEDGNPVPPGEVGELLTRGPYTIRGYYRAPEHNARAFTPDGFYRTGDLVRRTP 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 416 DGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKGVQR 495
Cdd:COG1021 422 DGYLVVEGRAKDQINRGGEKIAAEEVENLLLAHPAVHDAAVVAMPDEYLGERSCAFVVPRGEPLTLAELRRFLRERGLAA 501
|
490 500 510
....*....|....*....|....*....|..
gi 2740590833 496 HKIPDQWLFVAYWPLTAVGKINKRQLVQMAQA 527
Cdd:COG1021 502 FKLPDRLEFVDALPLTAVGKIDKKALRAALAA 533
|
|
| 23DHB-AMP_lg |
cd05920 |
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ... |
19-521 |
0e+00 |
|
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.
Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 677.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 19 WNGKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAH 98
Cdd:cd05920 12 WQDEPLGDLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 99 PVLLMPTQRAHDVHALCQIARPVAYIIPDCIHGFDYREMAREVAASCPelehiivdgeaeefipfasiedeplniigpgy 178
Cdd:cd05920 92 PVLALPSHRRSELSAFCAHAEAVAYIVPDRHAGFDHRALARELAESIP-------------------------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 179 gDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDTASC 258
Cdd:cd05920 140 -EVALFLLSGGTTGTPKLIPRTHNDYAYNVRASAEVCGLDQDTVYLAVLPAAHNFPLACPGVLGTLLAGGRVVLAPDPSP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 259 DEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEGLLCYTR 337
Cdd:cd05920 219 DAAFPLIEREGVTVTALVPALVSLWLDAAASRRADLSSLRLLQVGGARLSPALARRVPPVLGCtLQQVFGMAEGLLNYTR 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 338 LDDPYEVIINTQGRPLSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDG 417
Cdd:cd05920 299 LDDPDEVIIHTQGRPMSPDDEIRVVDEEGNPVPPGEEGELLTRGPYTIRGYYRAPEHNARAFTPDGFYRTGDLVRRTPDG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 418 NLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKGVQRHK 497
Cdd:cd05920 379 YLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVVAMPDELLGERSCAFVVLRDPPPSAAQLRRFLRERGLAAYK 458
|
490 500
....*....|....*....|....
gi 2740590833 498 IPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05920 459 LPDRIEFVDSLPLTAVGKIDKKAL 482
|
|
| DHB_AMP_lig |
TIGR02275 |
2,3-dihydroxybenzoate-AMP ligase; Proteins in this family belong to the AMP-binding enzyme ... |
19-521 |
0e+00 |
|
2,3-dihydroxybenzoate-AMP ligase; Proteins in this family belong to the AMP-binding enzyme family (pfam00501). Members activate 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate; many are involved in synthesis of siderophores such as enterobactin, vibriobactin, vulnibactin, etc. The most closely related proteine believed to differ in function activates salicylate rather than DHB. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 274063 [Multi-domain] Cd Length: 526 Bit Score: 572.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 19 WNGKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAH 98
Cdd:TIGR02275 20 WQDKPLTDILRDQAARYPDAIAIICGNRQWSYRELDQRADNLAAGLTKLGIKQGDTAVVQLPNIAEFYIVFFALLKLGVA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 99 PVLLMPTQRAHDVHALCQIARPVAYIIPDCIHGFDYREMAREVAASCPELEHIIVDG---EAEEFIPFASIEDePLNIIG 175
Cdd:TIGR02275 100 PVLALFSHRKSELTAYASQIEPALYIIDRAHSLFDYDDFARQLQSKLPTLRNIIVAGqtgEAELFLWLESPAE-PVKFPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 176 PGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDT 255
Cdd:TIGR02275 179 TKSDEVAFFQLSGGSTGTPKLIPRTHNDYYYSVRRSVEICWLTQQTRYLCALPAAHNYPLSSPGALGVFYAGGCVVLAPD 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 256 ASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLC 334
Cdd:TIGR02275 259 PSPTDCFPLIERHKVTVTALVPPAVALWMQAASKSRADLSSLKLLQVGGAKFSAAAARRVPAVFGcQLQQVFGMAEGLVN 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 YTRLDDPYEVIINTQGRPLSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIR 414
Cdd:TIGR02275 339 YTRLDDPAEIIFTTQGRPMSPDDEVRVVDDHGNPVAPGETGMLLTRGPYTFRGYYKAPEHNAAAFDAEGFYYTGDLVRLT 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 415 PDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKGVQ 494
Cdd:TIGR02275 419 PEGYIVVVGRAKDQINRGGEKIAAEEIENLLLAHPAVHDAALVSMPDELLGEKSCAFIVVRDPALKAAQLRRFLRERGLA 498
|
490 500
....*....|....*....|....*..
gi 2740590833 495 RHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:TIGR02275 499 EYKLPDRVEFVDSLPLTAVGKVDKKAL 525
|
|
| entE |
PRK10946 |
(2,3-dihydroxybenzoyl)adenylate synthase; |
37-527 |
2.21e-167 |
|
(2,3-dihydroxybenzoyl)adenylate synthase;
Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 500.67 E-value: 2.21e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQ 116
Cdd:PRK10946 38 DAIAVICGERQFSYRELNQASDNLACSLRRQGIKPGDTALVQLGNVAEFYITFFALLKLGVAPVNALFSHQRSELNAYAS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 IARPvAYIIPDCIHG-FDYREMAREVAASCPELEHIIVDGEAEEFIPFASIEDEPLNII-GPGYGD-IAVLLLSGGTTGT 193
Cdd:PRK10946 118 QIEP-ALLIADRQHAlFSDDDFLNTLVAEHSSLRVVLLLNDDGEHSLDDAINHPAEDFTaTPSPADeVAFFQLSGGSTGT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 194 PKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHL 273
Cdd:PRK10946 197 PKLIPRTHNDYYYSVRRSVEICGFTPQTRYLCALPAAHNYPMSSPGALGVFLAGGTVVLAPDPSATLCFPLIEKHQVNVT 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 274 ALVPALARLWEQA-RDWE-QSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRLDDPYEVIINTQG 350
Cdd:PRK10946 277 ALVPPAVSLWLQAiAEGGsRAQLASLKLLQVGGARLSETLARRIPAELGcQLQQVFGMAEGLVNYTRLDDSDERIFTTQG 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 351 RPLSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQIN 430
Cdd:PRK10946 357 RPMSPDDEVWVADADGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLVSIDPDGYITVVGREKDQIN 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 431 RSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLpkSINQP-DPAQMQAFLHQKGVQRHKIPDQWLFVAYWP 509
Cdd:PRK10946 437 RGGEKIAAEEIENLLLRHPAVIHAALVSMEDELMGEKSCAFL--VVKEPlKAVQLRRFLREQGIAEFKLPDRVECVDSLP 514
|
490
....*....|....*...
gi 2740590833 510 LTAVGKINKRQLVQMAQA 527
Cdd:PRK10946 515 LTAVGKVDKKQLRQWLAS 532
|
|
| salicyl_syn |
TIGR03494 |
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional ... |
557-979 |
2.12e-153 |
|
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional enzymes that make salicylate, in two steps, from chorismate. Members are homologous to anthranilate synthase component I from Trp biosynthesis. Members typically are found in gene regions associated with siderophore or other secondary metabolite biosynthesis.
Pssm-ID: 132533 [Multi-domain] Cd Length: 425 Bit Score: 460.40 E-value: 2.12e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 557 VTHLLADNDAPPCTLYEMKGEWSLGIGCAATISADASGQLIDSQGH-RHPYDISTLSQKLEQTLNALPIKDWRAYGRTLF 635
Cdd:TIGR03494 6 LAAVLSEFAEEDYYVYERDGEWYLGIGVQAMLTIDSDGRRVTFTGVtDRQRWSGSIGDAAREAVDALLLEGDRVFGQVGF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 636 EFSHMTYGLplepslvQQNEA---LIKITIPQHELRITQGQVLIRTLEEAQISILNEKVKraDQLGTPAFPQTKEVEIIN 712
Cdd:TIGR03494 86 EFAAHARGL-------QFNAGewpLLRLFVPRTEIVVTEDNVTLFGVSAGERRRLCRLVA--EGTTTTQIAPLPQARAVD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 713 TADTAKNYQDNVANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGRQANTPARSFFLRDGDFSAYGFSPETVVEAEG 792
Cdd:TIGR03494 157 TATDPSAYRARVARAVAEIAAGRYHKVILSRAVPLPFAIDFPATLLLGRRHNTPVRSFLLRLGGIEALGFSPELVMSVRA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 793 SGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHLASRV 872
Cdd:TIGR03494 237 DGKVVTEPLAGTRALGGGPEHDKQLRDELLSDSKEIVEHAISVKEAIEELEQVCEPGTVVVEDFMTVRERGSVQHLGSTV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 873 KGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAG 952
Cdd:TIGR03494 317 SGQLAPSKDAWDAFEVLFPAITASGIPKAAALEAIMRLEKTPRGLYSGAVLLLDADGTLDAALVLRAAYQDSGRTWLQAG 396
|
410 420
....*....|....*....|....*..
gi 2740590833 953 AGLVRNSRPEREWQETCEKLECIMKYV 979
Cdd:TIGR03494 397 AGIIAQSTPERELTETCEKLASIAPYL 423
|
|
| PRK07912 |
PRK07912 |
salicylate synthase; |
553-981 |
1.35e-119 |
|
salicylate synthase;
Pssm-ID: 169151 [Multi-domain] Cd Length: 449 Bit Score: 373.36 E-value: 1.35e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 553 PLDLVTHL---LADNDAPPCTLYEMKGEWSLGIGCAATISADASGQLI--DSQGHRHPYDISTlSQKLEQTLNALPIKDW 627
Cdd:PRK07912 25 PADLAAELaavVTESVGEDYLLYERDGQWVLAAGVQAMVELDSDELRVirDGVTRRQQWSGRP-GAALGEAVDRLLLETD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 628 RAYGRTLFEFSHMTYGLPlepSLVQQNEALIKITIPQHELRITQGQVLIRTLEEAQIsilnEKVKRADQLGTPAFPQTKE 707
Cdd:PRK07912 104 QAFGWVAFEFGVYRYGLQ---QRLAPGTPLARVFSPRTRIVVTEKGIRLFGAGIRHR----EAIDRLLATGVREVPQSRS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 708 VEIintADTAKNYQDNVANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGRQANTPARSFFLRDGDFSAYGFSPETV 787
Cdd:PRK07912 177 VDV---SDDPSGYRDRVAVAVAEIAAGRYHKVILSRCVEVPFAVDFPATYRLGRRHNTPVRSFLLRLGGIRALGYSPELV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 788 VEAEGSGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQH 867
Cdd:PRK07912 254 TAVRADGVVITEPLAGTRAFGRGAAIDRLARDDLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDFMTVRERGSVQH 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 868 LASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERC 947
Cdd:PRK07912 334 LGSTVRGRLDASSDRMDALEALFPAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRT 413
|
410 420 430
....*....|....*....|....*....|....
gi 2740590833 948 WLQAGAGLVRNSRPEREWQETCEKLECIMKYVRP 981
Cdd:PRK07912 414 WLRAGAGIIEESEPEREFEETCEKLSTLAPYLVA 447
|
|
| MenE/FadK |
COG0318 |
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ... |
24-532 |
7.97e-118 |
|
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 368.37 E-value: 7.97e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 24 LDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLM 103
Cdd:COG0318 1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 104 PTQRAHdvhalcqiarpvayiipdcihgfdyremarevaascpELEHIIVDGEAEEFIpfasiedeplniigpgygdIAV 183
Cdd:COG0318 81 PRLTAE-------------------------------------ELAYILEDSGARALV-------------------TAL 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 184 LLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSpGILGTLSQGGCVLLSDTASCDEAMP 263
Cdd:COG0318 105 ILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPGDVVLVALPLFHVFGLTV-GLLAPLLAGATLVLLPRFDPERVLE 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 264 LIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE-GLLCYTRLDDP 341
Cdd:COG0318 184 LIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLERFEERFGvRIVEGYGLTEtSPVVTVNPEDP 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 342 YEVIINTQGRPLsEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLV 421
Cdd:COG0318 264 GERRPGSVGRPL-PGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAFR-DGWLRTGDLGRLDEDGYLYI 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 422 EGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQRHKIPD 500
Cdd:COG0318 342 VGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVvLRPGAELDAEELRAFLRER-LARYKVPR 420
|
490 500 510
....*....|....*....|....*....|..
gi 2740590833 501 QWLFVAYWPLTAVGKINKRQLVQMAQAENTET 532
Cdd:COG0318 421 RVEFVDELPRTASGKIDRRALRERYAAGALEA 452
|
|
| Chorismate_bind |
pfam00425 |
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ... |
720-971 |
4.60e-94 |
|
chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Pssm-ID: 425674 [Multi-domain] Cd Length: 255 Bit Score: 298.31 E-value: 4.60e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 720 YQDNVANAVKDIASGHYQKVILSRQVELGSNIDIT--HSYWLGRQANTPARSFFLRDGDFSAYGFSPETVVEAEGsGWIN 797
Cdd:pfam00425 3 YLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGDIDplALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDG-GRII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 798 TQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHLASRVKGLLH 877
Cdd:pfam00425 82 TEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRLK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 878 TDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAGAGLVR 957
Cdd:pfam00425 162 PGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIVA 241
|
250
....*....|....
gi 2740590833 958 NSRPEREWQETCEK 971
Cdd:pfam00425 242 DSDPEAEWEETEAK 255
|
|
| PRK13295 |
PRK13295 |
cyclohexanecarboxylate-CoA ligase; Reviewed |
6-529 |
2.00e-93 |
|
cyclohexanecarboxylate-CoA ligase; Reviewed
Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 306.98 E-value: 2.00e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 6 IPEKTLTMTPNYLWNGKTLDQQLAGWSSIWGNKTALI------YHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQL 79
Cdd:PRK13295 8 LPPRRAASIAAGHWHDRTINDDLDACVASCPDKTAVTavrlgtGAPRRFTYRELAALVDRVAVGLARLGVGRGDVVSCQL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 80 PNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYIIPDCIHGFDYREMAREVAASCPELEHIIV-DGE-A 157
Cdd:PRK13295 88 PNWWEFTVLYLACSRIGAVLNPLMPIFRERELSFMLKHAESKVLVVPKTFRGFDHAAMARRLRPELPALRHVVVvGGDgA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 158 EEFIPFASI---EDEP-----LNIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPV 229
Cdd:PRK13295 168 DSFEALLITpawEQEPdapaiLARLRPGPDDVTQLIYTSGTTGEPKGVMHTANTLMANIVPYAERLGLGADDVILMASPM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 230 AH--NFILgspGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTH-LALVPALARLWEqARDWEQSDLSSLRCLQVGGGR 306
Cdd:PRK13295 248 AHqtGFMY---GLMMPVMLGATAVLQDIWDPARAAELIRTEGVTFtMASTPFLTDLTR-AVKESGRPVSSLRTFLCAGAP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 307 LTPELAEQVMARLGP-LQQVFGTAE-GLLCYTRLDDPYEVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYT 384
Cdd:PRK13295 324 IPGALVERARAALGAkIVSAWGMTEnGAVTLTKLDDPDERASTTDGCPLPGV-EVRVVDADGAPLPAGQIGRLQVRGCSN 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 385 ITGYYRAEQHNTVAftTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELL 464
Cdd:PRK13295 403 FGGYLKRPQLNGTD--ADGWFDTGDLARIDADGYIRISGRSKDVIIRGGENIPVVEIEALLYRHPAIAQVAIVAYPDERL 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740590833 465 GERICACL-PKSINQPDPAQMQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAEN 529
Cdd:PRK13295 481 GERACAFVvPRPGQSLDFEEMVEFLKAQKVAKQYIPERLVVRDALPRTPSGKIQKFRLREMLRGED 546
|
|
| AFD_class_I |
cd04433 |
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ... |
180-516 |
1.80e-89 |
|
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 289.19 E-value: 1.80e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGspGILGTLSQGGCVLLSDTASCD 259
Cdd:cd04433 1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGDVFLSTLPLFHIGGLF--GLLGALLAGGTVVLLPKFDPE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 260 EAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE--GLLCYT 336
Cdd:cd04433 79 AALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGiKLVNGYGLTEtgGTVATG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 RLDDPYEVIiNTQGRPLsEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEqHNTVAFTTDGFYRTGDLVRIRPD 416
Cdd:cd04433 159 PPDDDARKP-GSVGRPV-PGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNP-EATAAVDEDGWYRTGDLGRLDED 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 417 GNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQR 495
Cdd:cd04433 236 GYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVvLRPGADLDAEELRAHVRER-LAP 314
|
330 340
....*....|....*....|.
gi 2740590833 496 HKIPDQWLFVAYWPLTAVGKI 516
Cdd:cd04433 315 YKVPRRVVFVDALPRTASGKI 335
|
|
| PRK06772 |
PRK06772 |
salicylate synthase; |
569-979 |
2.55e-87 |
|
salicylate synthase;
Pssm-ID: 102546 [Multi-domain] Cd Length: 434 Bit Score: 287.02 E-value: 2.55e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 569 CTLYEMKGEWSLGIGCAATISADASGQ---LIDSQGHRHpYDISTLSQKLEQTLNALPIKDWRAYGRTLFEFSHMTYGLP 645
Cdd:PRK06772 32 CYVYERQPCWYLGKGCQARLHINADGTqatFIDDAGEQK-WAVDSIADCARRFMAHPQVKGRRVYGQVGFNFAAHARGIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 646 LEPSlvqqNEALIKITIPQHELRITQGQVLIRTLEEAQISILNEKVKRAdqlGTpafpQTKEVEI-INTADTAKNYQDNV 724
Cdd:PRK06772 111 FNAG----EWPLLTLTVPREELIFEKGNVTVYADSADGCRRLCEWVKEA---GT----TTQNAPLaVDTALNGEAYKQQV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 725 ANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGRQANTPARSFFLRDGDFSAYGFSPETVVEAEGSGWInTQPLAGT 804
Cdd:PRK06772 180 ARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALGFSPELVMSVTGNKVV-TEPLAGT 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 805 RALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHLASRVKGLLHTDKNRWD 884
Cdd:PRK06772 259 RDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENKDAWD 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 885 AFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTgKLDAALVLRSLYQHKERCWLQAGAGLVRNSRPERE 964
Cdd:PRK06772 339 AFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDT-RFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERE 417
|
410
....*....|....*
gi 2740590833 965 WQETCEKLECIMKYV 979
Cdd:PRK06772 418 LTETREKLASIAPYL 432
|
|
| TrpE |
COG0147 |
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ... |
545-980 |
5.49e-86 |
|
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439917 [Multi-domain] Cd Length: 416 Bit Score: 282.76 E-value: 5.49e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 545 HTIAITSTPLDLVTHLLadnDAPPCTLYE------MKGEWS-LGIGCAATISADASGQLIDSQGHRHPYDISTLSQkLEQ 617
Cdd:COG0147 7 RELLALETPVSLFLKLA---DGPYAFLLEsaeggeKWGRYSfIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDA-LRA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 618 TLNALPIKDwraygrtlfefshmTYGLPlepslvqqnealikitipqhelRITQGQV------LIRTLEeaqisilNEKV 691
Cdd:COG0147 83 LLARFRLPP--------------LPGLP----------------------PFTGGLVgyfgydLVRYFE-------RLPD 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 692 KRADQLGTP----AFPQT------KEVEIINTadTAKNYQDNVANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGR 761
Cdd:COG0147 120 LAPDDLGLPdaalGLYDRllvfdhLKGTRSNF--TREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALR 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 762 QANTPARSFFLRDGDFSAYGFSPETVVEAEGsGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEE 841
Cdd:COG0147 198 RINPSPYMFYLRFGDFAIVGSSPERLVRVED-GRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARND 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 842 LAPICQPETLCVSEFMAICERGSVQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGC 921
Cdd:COG0147 277 LGRVCEPGSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGA 356
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 2740590833 922 VMLLDSTGKLDAALVLRSLYQHKERCWLQAGAGLVRNSRPEREWQETCEKLECIMKYVR 980
Cdd:COG0147 357 VGYLSFDGNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALE 415
|
|
| AMP-binding |
pfam00501 |
AMP-binding enzyme; |
35-432 |
2.63e-82 |
|
AMP-binding enzyme;
Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 272.65 E-value: 2.63e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALIYHE-QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHA 113
Cdd:pfam00501 8 TPDKTALEVGEgRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRLPAEELAY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 LCQIARPVAYIIPDcihgFDYREMAREVAASCPELEHIIV--------DGEAEEFIPFASIEDEPLNIIGPGygDIAVLL 185
Cdd:pfam00501 88 ILEDSGAKVLITDD----ALKLEELLEALGKLEVVKLVLVldrdpvlkEEPLPEEAKPADVPPPPPPPPDPD--DLAYII 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPKLIPRTHDAYTYNFVLSARLC----AINTESVYLAVLPVAHnfILG-SPGILGTLSQGGCVLL--SDTASC 258
Cdd:pfam00501 162 YTSGTTGKPKGVMLTHRNLVANVLSIKRVRprgfGLGPDDRVLSTLPLFH--DFGlSLGLLGPLLAGATVVLppGFPALD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 259 DEAMP-LIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE--GLLC 334
Cdd:pfam00501 240 PAALLeLIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELARRFRELFGgALVNGYGLTEttGVVT 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 YTRLDDPYEVIINTQGRPLSEeDEINLADTN-LQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRI 413
Cdd:pfam00501 320 TPLPLDEDLRSLGSVGRPLPG-TEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLNDPELTAEAFDEDGWYRTGDLGRR 398
|
410
....*....|....*....
gi 2740590833 414 RPDGNLLVEGRIKEQINRS 432
Cdd:pfam00501 399 DEDGYLEIVGRKKDQIKLG 417
|
|
| FACL_FadD13-like |
cd17631 |
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ... |
36-518 |
2.50e-80 |
|
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.
Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 267.94 E-value: 2.50e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLmptqrahdvhalc 115
Cdd:cd17631 9 PDRTALVFGGRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPL------------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 qiarpvayiipdcihgfDYREMAREVAascpeleHIIVDGEAEEFIpfasiedeplniigpgyGDIAVLLLSGGTTGTPK 195
Cdd:cd17631 76 -----------------NFRLTPPEVA-------YILADSGAKVLF-----------------DDLALLMYTSGTTGRPK 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 196 LIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPgILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLAL 275
Cdd:cd17631 115 GAMLTHRNLLWNAVNALAALDLGPDDVLLVVAPLFHIGGLGVF-TLPTLLRGGTVVILRKFDPETVLDLIERHRVTSFFL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 276 VPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAE--GLLCYTRLDDPYEVIiNTQGRPL 353
Cdd:cd17631 194 VPTMIQALLQHPRFATTDLSSLRAVIYGGAPMPERLLRALQARGVKFVQGYGMTEtsPGVTFLSPEDHRRKL-GSAGRPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 354 SEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSG 433
Cdd:cd17631 273 FFVE-VRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEATAAAFR-DGWFHTGDLGRLDEDGYLYIVDRKKDMIISGG 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 434 EKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA-CLPKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTA 512
Cdd:cd17631 351 ENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAvVVPRPGAELDEDELIAHCRER-LARYKIPKSVEFVDALPRNA 429
|
....*.
gi 2740590833 513 VGKINK 518
Cdd:cd17631 430 TGKILK 435
|
|
| CHC_CoA_lg |
cd05903 |
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ... |
47-521 |
1.22e-77 |
|
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.
Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 260.78 E-value: 1.22e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYIIP 126
Cdd:cd05903 1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 DCIHGFDYREMArevaascpelehiivdgeaeefipfasiedeplniigpgyGDIAVLLLSGGTTGTPKLIPRTHDAYTY 206
Cdd:cd05903 81 ERFRQFDPAAMP----------------------------------------DAVALLLFTSGTTGEPKGVMHSHNTLSA 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 207 NFVLSARLCAINTESVYLAVLPVAH--NFILG--SPGILGTlsqggCVLLSDTASCDEAMPLIEEHKVTHLALVPA---- 278
Cdd:cd05903 121 SIRQYAERLGLGPGDVFLVASPMAHqtGFVYGftLPLLLGA-----PVVLQDIWDPDKALALMREHGVTFMMGATPfltd 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 279 LARLWEQARDweqsDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEGLLCYTRL-DDPYEVIINTQGRPLSEE 356
Cdd:cd05903 196 LLNAVEEAGE----PLSRLRTFVCGGATVPRSLARRAAELLGAkVCSAYGSTECPGAVTSItPAPEDRRLYTDGRPLPGV 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 357 dEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEqHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKI 436
Cdd:cd05903 272 -EIKVVDDTGATLAPGVEGELLSRGPSVFLGYLDRP-DLTADAAPEGWFRTGDLARLDEDGYLRITGRSKDIIIRGGENI 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 437 STLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGK 515
Cdd:cd05903 350 PVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVvTKSGALLTFDELVAYLDRQGVAKQYWPERLVHVDDLPRTPSGK 429
|
....*.
gi 2740590833 516 INKRQL 521
Cdd:cd05903 430 VQKFRL 435
|
|
| FC-FACS_FadD_like |
cd05936 |
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ... |
24-522 |
3.05e-76 |
|
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 257.88 E-value: 3.05e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 24 LDQQLAgwssIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLM 103
Cdd:cd05936 5 LEEAAR----RFPDKTALIFMGRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 104 PTQRAHDVHALCQIARPVAYIipdCIHGFdyremarevaascpelEHIIVDGEAEEFIPFASIEDeplniigpgygdIAV 183
Cdd:cd05936 81 PLYTPRELEHILNDSGAKALI---VAVSF----------------TDLLAAGAPLGERVALTPED------------VAV 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 184 LLLSGGTTGTPKLIPRTHdaytYNFVLSARLCAINTES------VYLAVLPVAHNFILGSPGILGTLSqGGCVLLSDTAS 257
Cdd:cd05936 130 LQYTSGTTGVPKGAMLTH----RNLVANALQIKAWLEDllegddVVLAALPLFHVFGLTVALLLPLAL-GATIVLIPRFR 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 258 CDEAMPLIEEHKVTHLALVPAL-ARLWEQArDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEG--LL 333
Cdd:cd05936 205 PIGVLKEIRKHRVTIFPGVPTMyIALLNAP-EFKKRDFSSLRLCISGGAPLPVEVAERFEELTGvPIVEGYGLTETspVV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 334 CYTRLDDPYEviINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRI 413
Cdd:cd05936 284 AVNPLDGPRK--PGSIGIPLPGT-EVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEETAEAFV-DGWLRTGDIGYM 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKg 492
Cdd:cd05936 360 DEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFVvLKEGASLTEEEIIAFCREQ- 438
|
490 500 510
....*....|....*....|....*....|
gi 2740590833 493 VQRHKIPDQWLFVAYWPLTAVGKINKRQLV 522
Cdd:cd05936 439 LAGYKVPRQVEFRDELPKSAVGKILRRELR 468
|
|
| PRK07656 |
PRK07656 |
long-chain-fatty-acid--CoA ligase; Validated |
36-521 |
1.54e-74 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 254.83 E-value: 1.54e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALC 115
Cdd:PRK07656 19 GDKEAYVFGDQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVVPLNTRYTADEAAYIL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 QIARPVAYIIPDCIHGFDYremarEVAASCPELEHIIV------DGEAEEFIPFAS-IEDEPLNIIGPGYG--DIAVLLL 186
Cdd:PRK07656 99 ARGDAKALFVLGLFLGVDY-----SATTRLPALEHVVIceteedDPHTEKMKTFTDfLAAGDPAERAPEVDpdDVADILF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 187 SGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILgSPGILGTLSQGGCVLLSDTASCDEAMPLIE 266
Cdd:PRK07656 174 TSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGDRYLAANPFFHVFGY-KAGVNAPLMRGATILPLPVFDPDEVFRLIE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 267 EHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGplqqvFGT---------AEGLLCYTR 337
Cdd:PRK07656 253 TERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAASMPVALLERFESELG-----VDIvltgyglseASGVTTFNR 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 338 LDDPYEVIINTQGRPLsEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDG 417
Cdd:PRK07656 328 LDDDRKTVAGTIGTAI-AGVENKIVNELGEEVPVGEVGELLVRGPNVMKGYYDDPEATAAAIDADGWLHTGDLGRLDEEG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 418 NLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA-CLPKSINQPDPAQMQAFlhqkgVQRH 496
Cdd:PRK07656 407 YLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDERLGEVGKAyVVLKPGAELTEEELIAY-----CREH 481
|
490 500
....*....|....*....|....*....
gi 2740590833 497 ----KIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK07656 482 lakyKVPRSIEFLDELPKNATGKVLKRAL 510
|
|
| PRK06187 |
PRK06187 |
long-chain-fatty-acid--CoA ligase; Validated |
23-521 |
1.74e-74 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 254.73 E-value: 1.74e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 23 TLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA--HPV 100
Cdd:PRK06187 7 TIGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAvlHPI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 101 --LLMPTQrahdvhalcqiarpVAYIIPDC-----IHGFDYREMAREVAASCPELEHIIV--DGEAEEFIPFAS-----I 166
Cdd:PRK06187 87 niRLKPEE--------------IAYILNDAedrvvLVDSEFVPLLAAILPQLPTVRTVIVegDGPAAPLAPEVGeyeelL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 167 EDEPLNIIGPGYG--DIAVLLLSGGTTGTPKLIPRTHDaytyNFVLSARLCA----INTESVYLAVLPVAHNFILGSPgI 240
Cdd:PRK06187 153 AAASDTFDFPDIDenDAAAMLYTSGTTGHPKGVVLSHR----NLFLHSLAVCawlkLSRDDVYLVIVPMFHVHAWGLP-Y 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 241 LGTLSqGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG 320
Cdd:PRK06187 228 LALMA-GAKQVIPRRFDPENLLDLIETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIYGGAALPPALLREFKEKFG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 321 -PLQQVFGTAE--GLLCYTRLDD---PYEVIINTQGRPLSEEdEINLADTNLQPVAPS--EVGELITRGPYTITGYYRAE 392
Cdd:PRK06187 307 iDLVQGYGMTEtsPVVSVLPPEDqlpGQWTKRRSAGRPLPGV-EARIVDDDGDELPPDggEVGEIIVRGPWLMQGYWNRP 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 393 QhNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL 472
Cdd:PRK06187 386 E-ATAETIDGGWLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGVPDEKWGERPVAVV 464
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 2740590833 473 -PKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK06187 465 vLKPGATLDAKELRAFLRGR-LAKFKLPKRIAFVDELPRTSVGKILKRVL 513
|
|
| Acs |
COG0365 |
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]; |
36-535 |
6.34e-68 |
|
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 237.70 E-value: 6.34e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYH-----EQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHD 110
Cdd:COG0365 23 GDKVALIWEgedgeERTLTYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSPVFPGFGAEA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 111 VHALCQIARPVAYIIPDCIH----GFDYREMAREVAASCPELEHIIVDGEA------------EEFIPFAS--IEDEPLN 172
Cdd:COG0365 103 LADRIEDAEAKVLITADGGLrggkVIDLKEKVDEALEELPSLEHVIVVGRTgadvpmegdldwDELLAAASaeFEPEPTD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 173 IigpgyGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCA-INTESVYLAVLPVAhnFILGSPGIL-GTLSQGGCV 250
Cdd:COG0365 183 A-----DDPLFILYTSGTTGKPKGVVHTHGGYLVHAATTAKYVLdLKPGDVFWCTADIG--WATGHSYIVyGPLLNGATV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 LL----SDTASCDEAMPLIEEHKVTHLALVPALARLWEQARDW--EQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQ 323
Cdd:COG0365 256 VLyegrPDFPDPGRLWELIEKYGVTVFFTAPTAIRALMKAGDEplKKYDLSSLRLLGSAGEPLNPEVWEWWYEAVGvPIV 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 324 QVFGTAEGLLCytrlddpyevIINTQ----------GRPLseedEINLADTNLQPVAPSEVGELITRGPYT--ITGYYRA 391
Cdd:COG0365 336 DGWGQTETGGI----------FISNLpglpvkpgsmGKPVpg-yDVAVVDEDGNPVPPGEEGELVIKGPWPgmFRGYWND 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 392 EQ--HNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERIC 469
Cdd:COG0365 405 PEryRETYFGRFPGWYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGTAEIESALVSHPAVAEAAVVGVPDEIRGQVVK 484
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2740590833 470 A-CLPKSINQPDPA---QMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAEN---TETAEN 535
Cdd:COG0365 485 AfVVLKPGVEPSDElakELQAHV-REELGPYAYPREIEFVDELPKTRSGKIMRRLLRKIAEGRPlgdTSTLED 556
|
|
| PRK06087 |
PRK06087 |
medium-chain fatty-acid--CoA ligase; |
35-523 |
8.28e-66 |
|
medium-chain fatty-acid--CoA ligase;
Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 231.56 E-value: 8.28e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALIYHEQRL-----------------TYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA 97
Cdd:PRK06087 20 WGDASLADYWQQTArampdkiavvdnhgasyTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 98 HPVLLMPTQRAHDVHALCQIARPVAYIIPDCIHGFDYREMAREVAASCPELEHII-VDGEAEEF--IPFASI--EDEPLN 172
Cdd:PRK06087 100 VSVPLLPSWREAELVWVLNKCQAKMFFAPTLFKQTRPVDLILPLQNQLPQLQQIVgVDKLAPATssLSLSQIiaDYEPLT 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 173 IIGPGYGD-IAVLLLSGGTTGTPKLIPRTHDaytyNFVLSAR-LCA---INTESVYLAVLPVAH--NFILG--SPGILGt 243
Cdd:PRK06087 180 TAITTHGDeLAAVLFTSGTEGLPKGVMLTHN----NILASERaYCArlnLTWQDVFMMPAPLGHatGFLHGvtAPFLIG- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 244 lsqgGCVLLSDTASCDEAMPLIEEHKVT-HLALVPALARLWEQARDwEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPL 322
Cdd:PRK06087 255 ----ARSVLLDIFTPDACLALLEQQRCTcMLGATPFIYDLLNLLEK-QPADLSALRFFLCGGTTIPKKVARECQQRGIKL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 323 QQVFGTAEGL-LCYTRLDDPYEVIINTQGRPLsEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTT 401
Cdd:PRK06087 330 LSVYGSTESSpHAVVNLDDPLSRFMHTDGYAA-AGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYLDEPELTARALDE 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 402 DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSINQP 479
Cdd:PRK06087 409 EGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDERLGERSCAyvVLKAPHHSL 488
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 2740590833 480 DPAQMQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQ 523
Cdd:PRK06087 489 TLEEVVAFFSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRK 532
|
|
| A_NRPS |
cd05930 |
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ... |
37-521 |
8.14e-63 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 220.09 E-value: 8.14e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvha 113
Cdd:cd05930 2 DAVAVVDGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLdpsYPAER------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 lcqiarpVAYIIPDcihgfdyremarevaaSCPELehIIVDGeaeefipfasiedeplniigpgyGDIAVLLLSGGTTGT 193
Cdd:cd05930 76 -------LAYILED----------------SGAKL--VLTDP-----------------------DDLAYVIYTSGSTGK 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 194 PKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLL--SDTASCDEAMP-LIEEHKV 270
Cdd:cd05930 108 PKGVMVEHRGLVNLLLWMQEAYPLTPGDRVLQFTSFS--FDVSVWEIFGALLAGATLVVlpEEVRKDPEALAdLLAEEGI 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 271 THLALVPALARLWEQARDWEqsDLSSLRCLQVGGGRLTPELAEQVmARLGPLQQVF---GTAEGLLC--YTRLDDPYE-- 343
Cdd:cd05930 186 TVLHLTPSLLRLLLQELELA--ALPSLRLVLVGGEALPPDLVRRW-RELLPGARLVnlyGPTEATVDatYYRVPPDDEed 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 --VIIntqGRPLSeedeiNLA----DTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLV 411
Cdd:cd05930 263 grVPI---GRPIP-----NTRvyvlDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPNPFgpgermYRTGDLV 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 412 RIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQ 490
Cdd:cd05930 335 RWLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEKRLVAYVvPDEGGELDEEELRAHLAE 414
|
490 500 510
....*....|....*....|....*....|.
gi 2740590833 491 KgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05930 415 R-LPDYMVPSAFVVLDALPLTPNGKVDRKAL 444
|
|
| PRK07470 |
PRK07470 |
acyl-CoA synthetase; Validated |
36-521 |
6.06e-61 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 217.22 E-value: 6.06e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvLLMPT---QRAHDVH 112
Cdd:PRK07470 21 PDRIALVWGDRSWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGA---VWVPTnfrQTPDEVA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 113 ALCQIARPVAYIipdCiHGfDYREMAREVAASCPELEHIIVDGEAEEFIPFASIEDEPLniiGPGYGDIAV-------LL 185
Cdd:PRK07470 98 YLAEASGARAMI---C-HA-DFPEHAAAVRAASPDLTHVVAIGGARAGLDYEALVARHL---GARVANAAVdhddpcwFF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPKLIPRTHDayTYNFVLSARLC----AINTESVYLAVLPVAHnfilgSPGI--LGTLSQGG-CVLL-SDTAS 257
Cdd:PRK07470 170 FTSGTTGRPKAAVLTHG--QMAFVITNHLAdlmpGTTEQDASLVVAPLSH-----GAGIhqLCQVARGAaTVLLpSERFD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 258 CDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEGLLCYT 336
Cdd:PRK07470 243 PAEVWALVERHRVTNLFTVPTILKMLVEHPAVDRYDHSSLRYVIYAGAPMYRADQKRALAKLGKvLVQYFGLGEVTGNIT 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 RL-------DDPYEVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFtTDGFYRTGD 409
Cdd:PRK07470 323 VLppalhdaEDGPDARIGTCGFERTGM-EVQIQDDEGRELPPGETGEICVIGPAVFAGYYNNPEANAKAF-RDGWFRTGD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 410 LVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGE-RICACLPKSINQPDPAQMQAFL 488
Cdd:PRK07470 401 LGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVLGVPDPVWGEvGVAVCVARDGAPVDEAELLAWL 480
|
490 500 510
....*....|....*....|....*....|...
gi 2740590833 489 HQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK07470 481 DGK-VARYKLPKRFFFWDALPKSGYGKITKKMV 512
|
|
| FACL_fum10p_like |
cd05926 |
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ... |
48-523 |
6.09e-61 |
|
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.
Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 216.02 E-value: 6.09e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYIIPD 127
Cdd:cd05926 15 LTYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEFYLADLGSKLVLTPK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 CIHGFDYR-----EMAREVAASCPELEHIIVDGE----AEEFIPFASIEDEPLNiigpgyGDIAVLLLSGGTTGTPKLIP 198
Cdd:cd05926 95 GELGPASRaasklGLAILELALDVGVLIRAPSAEslsnLLADKKNAKSEGVPLP------DDLALILHTSGTTGRPKGVP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 199 RTHDaytyNFVLSARlcaiNTESVY--------LAVLPVAH-NFILGSpgILGTLSQGGCVLLSDTASCDEAMPLIEEHK 269
Cdd:cd05926 169 LTHR----NLAASAT----NITNTYkltpddrtLVVMPLFHvHGLVAS--LLSTLAAGGSVVLPPRFSASTFWPDVRDYN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 270 VTHLALVPALAR-LWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGllCYTRLDDPYEVI-- 345
Cdd:cd05926 239 ATWYTAVPTIHQiLLNRPEPNPESPPPKLRFIRSCSASLPPAVLEALEATFGaPVLEAYGMTEA--AHQMTSNPLPPGpr 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 346 -INTQGRPLSEEDEINLADTNLQPvaPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGR 424
Cdd:cd05926 317 kPGSVGKPVGVEVRILDEDGEILP--PGVVGEICLRGPNVTRGYLNNPEANAEAAFKDGWFRTGDLGYLDADGYLFLTGR 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 425 IKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERI-CACLPKSINQPDPAQMQAFLhQKGVQRHKIPDQWL 503
Cdd:cd05926 395 IKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVaAAVVLREGASVTEEELRAFC-RKHLAAFKVPKKVY 473
|
490 500
....*....|....*....|
gi 2740590833 504 FVAYWPLTAVGKINKRQLVQ 523
Cdd:cd05926 474 FVDELPKTATGKIQRRKVAE 493
|
|
| LC_FACS_like |
cd05935 |
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ... |
47-521 |
5.23e-60 |
|
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.
Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 211.57 E-value: 5.23e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPtqrahdvhalcqiarpvayiip 126
Cdd:cd05935 1 SLTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINP---------------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 dcihgfdyreMAREVaascpELEHIIVDGEAEEFIPFASIEDeplniigpgygdIAVLLLSGGTTGTPKLIPRTHDAYTY 206
Cdd:cd05935 59 ----------MLKER-----ELEYILNDSGAKVAVVGSELDD------------LALIPYTSGTTGLPKGCMHTHFSAAA 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 207 NFVLSARLCAINTESVYLAVLPVAHnfILGSPGILGT-LSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALARLWEQ 285
Cdd:cd05935 112 NALQSAVWTGLTPSDVILACLPLFH--VTGFVGSLNTaVYVGGTYVLMARWDRETALELIEKYKVTFWTNIPTMLVDLLA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 286 ARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLlCYTRLDDPYEVIINTQGRPLSEEDEINLADT 364
Cdd:cd05935 190 TPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGlRFVEGYGLTETM-SQTHTNPPLRPKLQCLGIP*FGVDARVIDIE 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 365 NLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDG---FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEV 441
Cdd:cd05935 269 TGRELPPNEVGEIVVRGPQIFKGYWNRPEETEESFIEIKgrrFFRTGDLGYMDEEGYFFFVDRVKRMINVSGFKVWPAEV 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 442 ETLLLQHPDIDDTVVIAVPDELLGERICACL---PKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINK 518
Cdd:cd05935 349 EAKLYKHPAI*EVCVISVPDERVGEEVKAFIvlrPEYRGKVTEEDIIEWAREQ-MAAYKYPREVEFVDELPRSASGKILW 427
|
...
gi 2740590833 519 RQL 521
Cdd:cd05935 428 RLL 430
|
|
| PRK06164 |
PRK06164 |
acyl-CoA synthetase; Validated |
39-527 |
3.78e-58 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 209.60 E-value: 3.78e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIA 118
Cdd:PRK06164 27 VALIDEDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATVIAVNTRYRSHEVAHILGRG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 119 RPVAYIIPDCIHGFDYREMAREVA-ASCPELEHIIVDGEAEEFIP------------FASIEDEPLNIIGPGYGDIAVLL 185
Cdd:PRK06164 107 RARWLVVWPGFKGIDFAAILAAVPpDALPPLRAIAVVDDAADATPapapgarvqlfaLPDPAPPAAAGERAADPDAGALL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 L-SGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFilGSPGILGTLSQGGCVLLSDTASCDEAMPL 264
Cdd:PRK06164 187 FtTSGTTSGPKLVLHRQATLLRHARAIARAYGYDPGAVLLAALPFCGVF--GFSTLLGALAGGAPLVCEPVFDAARTARA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 265 IEEHKVTH-LALVPALARLWEQARdwEQSDLSSLRCLqvGGGRLTP---ELAEQVMARLGPLQQVFGTAE--GLLCYTRL 338
Cdd:PRK06164 265 LRRHRVTHtFGNDEMLRRILDTAG--ERADFPSARLF--GFASFAPalgELAALARARGVPLTGLYGSSEvqALVALQPA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 339 DDPYEVIINTQGRPLSEEDEINLADTNLQPVAP-SEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDG 417
Cdd:PRK06164 341 TDPVSVRIEGGGRPASPEARVRARDPQDGALLPdGESGEIEIRAPSLMRGYLDNPDATARALTDDGYFRTGDLGYTRGDG 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 418 NLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVpdELLGERICAC--LPKSINQPDPAQMQAFLhQKGVQR 495
Cdd:PRK06164 421 QFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGA--TRDGKTVPVAfvIPTDGASPDEAGLMAAC-REALAG 497
|
490 500 510
....*....|....*....|....*....|....*
gi 2740590833 496 HKIPDQWLFVAYWPLTAVG---KINKRQLVQMAQA 527
Cdd:PRK06164 498 FKVPARVQVVEAFPVTESAngaKIQKHRLREMAQA 532
|
|
| Firefly_Luc_like |
cd05911 |
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ... |
46-517 |
8.83e-58 |
|
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 207.07 E-value: 8.83e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPvAYII 125
Cdd:cd05911 9 KELTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKP-KVIF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 --PDCIhgfdyrEMAREVAASCPELEHIIVDGEAEEFIPFASIEDEPLNII---------GPGYGDIAVLLLSGGTTGTP 194
Cdd:cd05911 88 tdPDGL------EKVKEAAKELGPKDKIIVLDDKPDGVLSIEDLLSPTLGEededlppplKDGKDDTAAILYSSGTTGLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 195 KLIPRTHDAYTYN--FVLSARLCAINTESVYLAVLPVAHnfILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTH 272
Cdd:cd05911 162 KGVCLSHRNLIANlsQVQTFLYGNDGSNDVILGFLPLYH--IYGLFTTLASLLNGATVIIMPKFDSELFLDLIEKYKITF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP--LQQVFGTAE--GLLCYTRLDDPY-----E 343
Cdd:cd05911 240 LYLVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNatIKQGYGMTEtgGILTVNPDGDDKpgsvgR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 VIINTQGRPLSEEDEinladtnlQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEG 423
Cdd:cd05911 320 LLPNVEAKIVDDDGK--------DSLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGWLHTGDIGYFDEDGYLYIVD 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 424 RIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKGVQRHKIPDQW 502
Cdd:cd05911 392 RKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVvRKPGEKLTEKEVKDYVAKKVASYKQLRGGV 471
|
490
....*....|....*
gi 2740590833 503 LFVAYWPLTAVGKIN 517
Cdd:cd05911 472 VFVDEIPKSASGKIL 486
|
|
| 4CL |
cd05904 |
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ... |
23-521 |
2.75e-57 |
|
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.
Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 205.93 E-value: 2.75e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 23 TLDQQLAGWSSIWGNKTALI--YHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA--- 97
Cdd:cd05904 6 PLDSVSFLFASAHPSRPALIdaATGRALTYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAvvt 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 98 --HPvLLMPTQRAHDVHAlcqiARPVaYIIPDCihgfdyrEMAREVAASCPElehIIVDGEAeefiPFASIEDEPLNIIG 175
Cdd:cd05904 86 taNP-LSTPAEIAKQVKD----SGAK-LAFTTA-------ELAEKLASLALP---VVLLDSA----EFDSLSFSDLLFEA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 176 PGYG---------DIAVLLLSGGTTGTPKLIPRTHDaytyNFVlsARLCAINT--------ESVYLAVLPVAHNFILGSP 238
Cdd:cd05904 146 DEAEppvvvikqdDVAALLYSSGTTGRSKGVMLTHR----NLI--AMVAQFVAgegsnsdsEDVFLCVLPMFHIYGLSSF 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 239 gILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVP----ALARlweqARDWEQSDLSSLRCLQVGGGRLTPELAEQ 314
Cdd:cd05904 220 -ALGLLRLGATVVVMPRFDLEELLAAIERYKVTHLPVVPpivlALVK----SPIVDKYDLSSLRQIMSGAAPLGKELIEA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 315 VMARLG--PLQQVFG----TAEGLLCYTRLDDPYEviINTQGRpLSEEDEINLADTN-LQPVAPSEVGELITRGPYTITG 387
Cdd:cd05904 295 FRAKFPnvDLGQGYGmtesTGVVAMCFAPEKDRAK--YGSVGR-LVPNVEAKIVDPEtGESLPPNQTGELWIRGPSIMKG 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 388 YYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGER 467
Cdd:cd05904 372 YLNNPEATAATIDKEGWLHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEV 451
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 468 ICACLPKsinQPD----PAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05904 452 PMAFVVR---KPGssltEDEIMDFV-AKQVAPYKKVRKVAFVDAIPKSPSGKILRKEL 505
|
|
| FACL_DitJ_like |
cd05934 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
45-521 |
3.29e-57 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.
Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 203.29 E-value: 3.29e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 45 EQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHdvhalcqiarpvayi 124
Cdd:cd05934 1 GRRWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGD--------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 125 ipdcihgfdyremarevaascpELEHIIVDGEAEefipfasiedepLNIIgpgygDIAVLLLSGGTTGTPKLIPRTHDAY 204
Cdd:cd05934 66 ----------------------ELAYIIDHSGAQ------------LVVV-----DPASILYTSGTTGPPKGVVITHANL 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 205 TYNFVLSARLCAINTESVYLAVLPVAH-NFILGSpgILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALAR-L 282
Cdd:cd05934 107 TFAGYYSARRFGLGEDDVYLTVLPLFHiNAQAVS--VLAALSVGATLVLLPRFSASRFWSDVRRYGATVTNYLGAMLSyL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 283 WEQARDWEQSDlSSLRClqVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRlDDPYEVIINTQGRPLSEEdEINL 361
Cdd:cd05934 185 LAQPPSPDDRA-HRLRA--AYGAPNPPELHEEFEERFGvRLLEGYGMTETIVGVIG-PRDEPRRPGSIGRPAPGY-EVRI 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 362 ADTNLQPVAPSEVGELITRG--PYTI-TGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKIST 438
Cdd:cd05934 260 VDDDGQELPAGEPGELVIRGlrGWGFfKGYYNMPEATAEAMR-NGWFHTGDLGYRDADGFFYFVDRKKDMIRRRGENISS 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 439 LEVETLLLQHPDIDDTVVIAVPDELLGERICACLpkSINQPDPAQMQAFLH--QKGVQRHKIPDQWLFVAYWPLTAVGKI 516
Cdd:cd05934 339 AEVERAILRHPAVREAAVVAVPDEVGEDEVKAVV--VLRPGETLDPEELFAfcEGQLAYFKVPRYIRFVDDLPKTPTEKV 416
|
....*
gi 2740590833 517 NKRQL 521
Cdd:cd05934 417 AKAQL 421
|
|
| PRK08315 |
PRK08315 |
AMP-binding domain protein; Validated |
21-528 |
3.15e-56 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 204.27 E-value: 3.15e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 21 GKTLDQQLAGWSSIWGNKTALIYHEQ--RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAH 98
Cdd:PRK08315 15 EQTIGQLLDRTAARYPDREALVYRDQglRWTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPEWVLTQFATAKIGAI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 99 PVLLMPTQRAHDV-HALCQIArpVAYIIpdCIHGF---DYREMAREVAASC-------------PELEHIIVDGEAEE-- 159
Cdd:PRK08315 95 LVTINPAYRLSELeYALNQSG--CKALI--AADGFkdsDYVAMLYELAPELatcepgqlqsarlPELRRVIFLGDEKHpg 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 160 FIPFASIEDEPLNIIGPGYGDIAVLL---------LSGGTTGTPKLIPRTH-----DAY----TYNFVLSARLCaintes 221
Cdd:PRK08315 171 MLNFDELLALGRAVDDAELAARQATLdpddpiniqYTSGTTGFPKGATLTHrnilnNGYfigeAMKLTEEDRLC------ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 222 vylavLPVA--HNF--ILGSpgiLGTLSQGGC-VLLSDtaSCDEAMPL--IEEHKVTHLALVPA--LARLweQARDWEQS 292
Cdd:PRK08315 245 -----IPVPlyHCFgmVLGN---LACVTHGATmVYPGE--GFDPLATLaaVEEERCTALYGVPTmfIAEL--DHPDFARF 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 293 DLSSLRclqVG--GGRLTP-ELAEQVMARLGpLQQV---FGTAEG--LLCYTRLDDPYEVIINTQGRPLsEEDEINLADT 364
Cdd:PRK08315 313 DLSSLR---TGimAGSPCPiEVMKRVIDKMH-MSEVtiaYGMTETspVSTQTRTDDPLEKRVTTVGRAL-PHLEVKIVDP 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 365 NL-QPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVET 443
Cdd:PRK08315 388 ETgETVPRGEQGELCTRGYSVMKGYWNDPEKTAEAIDADGWMHTGDLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEE 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 444 LLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLV 522
Cdd:PRK08315 468 FLYTHPKIQDVQVVGVPDEKYGEEVCAWIiLRPGATLTEEDVRDFCRGK-IAHYKIPRYIRFVDEFPMTVTGKIQKFKMR 546
|
....*.
gi 2740590833 523 QMAQAE 528
Cdd:PRK08315 547 EMMIEE 552
|
|
| PRK08314 |
PRK08314 |
long-chain-fatty-acid--CoA ligase; Validated |
37-521 |
1.05e-54 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 199.80 E-value: 1.05e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAhdvhalc 115
Cdd:PRK08314 25 DKTAIVFYGRAISYRELLEEAERLAGYLQQEcGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVPVNPMNRE------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 qiaRPVAYIIPDC-----IHGFDYREMAREVAASCPeLEHIIV-------DGEAEEFIP---FASIEDEPLNIIG----- 175
Cdd:PRK08314 98 ---EELAHYVTDSgarvaIVGSELAPKVAPAVGNLR-LRHVIVaqysdylPAEPEIAVPawlRAEPPLQALAPGGvvawk 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 176 -------------PGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHnfILG-SPGIL 241
Cdd:PRK08314 174 ealaaglappphtAGPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPESVVLAVLPLFH--VTGmVHSMN 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 242 GTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLqVGGGRLTPE-LAEQvmarlg 320
Cdd:PRK08314 252 APIYAGATVVLMPRWDREAAARLIERYRVTHWTNIPTMVVDFLASPGLAERDLSSLRYI-GGGGAAMPEaVAER------ 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 321 pLQQVFGtaeglLCYTrldDPY---EVI----INTQGRPLSEEDEINLADTN--------LQPVAPSEVGELITRGPYTI 385
Cdd:PRK08314 325 -LKELTG-----LDYV---EGYgltETMaqthSNPPDRPKLQCLGIPTFGVDarvidpetLEELPPGEVGEIVVHGPQVF 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 386 TGYYRAEQHNTVAFTT-DG--FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDE 462
Cdd:PRK08314 396 KGYWNRPEATAEAFIEiDGkrFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHPAIQEACVIATPDP 475
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 463 LLGERICACL---PKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK08314 476 RRGETVKAVVvlrPEARGKTTEEEIIAWAREH-MAAYKYPRIVEFVDSLPKSGSGKILWRQL 536
|
|
| PRK06188 |
PRK06188 |
acyl-CoA synthetase; Validated |
12-521 |
2.13e-53 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 195.20 E-value: 2.13e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 12 TMTPNYLWNGKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNR----ISFVV 87
Cdd:PRK06188 2 ATMADLLHSGATYGHLLVSALKRYPDRPALVLGDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRpevlMAIGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 88 TCFALFRLGA-HPvllMPTQRAHdvhalcqiarpvAYIIPDC------IHGFDYREMAREVAASCPELEHIIVDGEAEEF 160
Cdd:PRK06188 82 AQLAGLRRTAlHP---LGSLDDH------------AYVLEDAgistliVDPAPFVERALALLARVPSLKHVLTLGPVPDG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 161 IPF----ASIEDEPLnIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTynfVLSARLCA---INTESVYLAVLPVAHnf 233
Cdd:PRK06188 147 VDLlaaaAKFGPAPL-VAAALPPDIAGLAYTGGTTGKPKGVMGTHRSIA---TMAQIQLAeweWPADPRFLMCTPLSH-- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 234 iLGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPA-LARLWEQARDwEQSDLSSLRCLQVGGGRLTP-EL 311
Cdd:PRK06188 221 -AGGAFFLPTLLRGGTVIVLAKFDPAEVLRAIEEQRITATFLVPTmIYALLDHPDL-RTRDLSSLETVYYGASPMSPvRL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 312 AEqVMARLGP-LQQVFGTAEGLLCYTRL-----DDPYEVIINTQGRPlSEEDEINLADTNLQPVAPSEVGELITRGPYTI 385
Cdd:PRK06188 299 AE-AIERFGPiFAQYYGQTEAPMVITYLrkrdhDPDDPKRLTSCGRP-TPGLRVALLDEDGREVAQGEVGEICVRGPLVM 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 386 TGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLG 465
Cdd:PRK06188 377 DGYWNRPEETAEAFR-DGWLHTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGVPDEKWG 455
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 466 ERICAC-LPKSINQPDPAQMQAFL-HQKGVqrHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK06188 456 EAVTAVvVLRPGAAVDAAELQAHVkERKGS--VHAPKQVDFVDSLPLTALGKPDKKAL 511
|
|
| menE |
TIGR01923 |
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ... |
49-521 |
3.02e-53 |
|
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 162605 [Multi-domain] Cd Length: 436 Bit Score: 192.66 E-value: 3.02e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 49 TYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHdvHALCQIAR-PVAYIIpd 127
Cdd:TIGR01923 1 TWQDLDCEAAHLAKALKAQGIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTEN--ERTNQLEDlDVQLLL-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 cihgfdyremarevAASCPELEHIIVDGEAEefIPFASIEDEPLNIIGPGyGDIAVLLLSGGTTGTPKLIPRTHDAYTYN 207
Cdd:TIGR01923 77 --------------TDSLLEEKDFQADSLDR--IEAAGRYETSLSASFNM-DQIATLMFTSGTTGKPKAVPHTFRNHYAS 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 208 FVLSARLCAINTESVYLAVLPVAHnfILGSPGILGTLSQGGCVLLSDTAScdEAMPLIEEHKVTHLALVPA-LARLWEqa 286
Cdd:TIGR01923 140 AVGSKENLGFTEDDNWLLSLPLYH--ISGLSILFRWLIEGATLRIVDKFN--QLLEMIANERVTHISLVPTqLNRLLD-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 287 rdwEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEGLLCYTRLDDPYEVIINTQGRPL-SEEDEINLADTn 365
Cdd:TIGR01923 214 ---EGGHNENLRKILLGGSAIPAPLIEEAQQYGLPIYLSYGMTETCSQVTTATPEMLHARPDVGRPLaGREIKIKVDNK- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 366 lqpvapSEVGELITRGPYTITGYYRAEQHNTvAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLL 445
Cdd:TIGR01923 290 ------EGHGEIMVKGANLMKGYLYQGELTP-AFEQQGWFNTGDIGELDGEGFLYVLGRRDDLIISGGENIYPEEIETVL 362
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740590833 446 LQHPDIDDTVVIAVPDELLGERICACLpKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:TIGR01923 363 YQHPGIQEAVVVPKPDAEWGQVPVAYI-VSESDISQAKLIAYLTEK-LAKYKVPIAFEKLDELPYNASGKILRNQL 436
|
|
| AA-adenyl-dom |
TIGR01733 |
amino acid adenylation domain; This model represents a domain responsible for the specific ... |
49-456 |
4.34e-53 |
|
amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.
Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 191.32 E-value: 4.34e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 49 TYHELHQSAERLANGL-YHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvhalcqiarpVAYI 124
Cdd:TIGR01733 1 TYRELDERANRLARHLrAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLdpaYPAER-------------LAFI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 125 IPDCIHGF-----DYREMAREVAascpeLEHIIVDGEAEEFIPFASIEDEPLNIIGPGygDIAVLLLSGGTTGTPKLIPR 199
Cdd:TIGR01733 68 LEDAGARLlltdsALASRLAGLV-----LPVILLDPLELAALDDAPAPPPPDAPSGPD--DLAYVIYTSGSTGRPKGVVV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 THDAYTyNFVLSARLCAINTE-SVYLAVLPVAHNFILGSpgILGTLSQGGC-VLLSDTASCDEAM---PLIEEHKVTHLA 274
Cdd:TIGR01733 141 THRSLV-NLLAWLARRYGLDPdDRVLQFASLSFDASVEE--IFGALLAGATlVVPPEDEERDDAAllaALIAEHPVTVLN 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 275 LVPALARLWEQARDweqSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQ--QVFGTAEGLLC-----YTRLDDPYEVIIN 347
Cdd:TIGR01733 218 LTPSLLALLAAALP---PALASLRLVILGGEALTPALVDRWRARGPGARliNLYGPTETTVWstatlVDPDDAPRESPVP 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 348 TqGRPLSeedeiNLA----DTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF--------YRTGDLVRIRP 415
Cdd:TIGR01733 295 I-GRPLA-----NTRlyvlDDDLRPVPVGVVGELYIGGPGVARGYLNRPELTAERFVPDPFaggdgarlYRTGDLVRYLP 368
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 2740590833 416 DGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVV 456
Cdd:TIGR01733 369 DGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGVREAVV 409
|
|
| A_NRPS_Srf_like |
cd12117 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ... |
35-521 |
1.06e-52 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.
Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 192.42 E-value: 1.06e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHAL 114
Cdd:cd12117 10 TPDAVAVVYGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPELPAERLAFM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 CQIARPVAYIipdcihgfDYREMAREVAASCPELEHIIVDGEAEEfipfasieDEPLNIIGPGygDIAVLLLSGGTTGTP 194
Cdd:cd12117 90 LADAGAKVLL--------TDRSLAGRAGGLEVAVVIDEALDAGPA--------GNPAVPVSPD--DLAYVMYTSGSTGRP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 195 KLIPRTHDAYTyNFVLSARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLLSDT---ASCDEAMPLIEEHKVT 271
Cdd:cd12117 152 KGVAVTHRGVV-RLVKNTNYVTLGPDDRVLQTSPLA--FDASTFEIWGALLNGARLVLAPKgtlLDPDALGALIAEEGVT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPALAR-LWEQARDWeqsdLSSLRCLQVGGGRLTPELAEQVMARLGPLQQV--FGTAEGLLCYT--RLDDPYEVI- 345
Cdd:cd12117 229 VLWLTAALFNqLADEDPEC----FAGLRELLTGGEVVSPPHVRRVLAACPGLRLVngYGPTENTTFTTshVVTELDEVAg 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 346 ---IntqGRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRIRPD 416
Cdd:cd12117 305 sipI---GRPIANTR-VYVLDEDGRPVPPGVPGELYVGGDGLALGYLNRPALTAERFVADPFgpgerlYRTGDLARWLPD 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 417 GNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSiNQPDPAQMQAFLHQKgVQRH 496
Cdd:cd12117 381 GRLEFLGRIDDQVKIRGFRIELGEIEAALRAHPGVREAVVVVREDAGGDKRLVAYVVAE-GALDAAELRAFLRER-LPAY 458
|
490 500
....*....|....*....|....*
gi 2740590833 497 KIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd12117 459 MVPAAFVVLDELPLTANGKVDRRAL 483
|
|
| CBAL |
cd05923 |
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ... |
47-521 |
1.08e-52 |
|
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.
Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 192.72 E-value: 1.08e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYIIP 126
Cdd:cd05923 28 RLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVPALINPRLKAAELAELIERGEMTAAVIA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 DCihgfdyREMAREVAASCPELEHIIVD---GEAEEFIPfaSIEDEPlniigPGYGDIAVLLLSGGTTGTPK--LIPRTH 201
Cdd:cd05923 108 VD------AQVMDAIFQSGVRVLALSDLvglGEPESAGP--LIEDPP-----REPEQPAFVFYTSGTTGLPKgaVIPQRA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 202 DAytynfvlsARLCAINTES--------VYLAVLPVAHnfILGSPGIL-GTLSQGGCVLLSDTASCDEAMPLIEEHKVTH 272
Cdd:cd05923 175 AE--------SRVLFMSTQAglrhgrhnVVLGLMPLYH--VIGFFAVLvAALALDGTYVVVEEFDPADALKLIEQERVTS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVP----ALARLWEQArdweQSDLSSLRCLQVGGGRLTPELAEQVMARL-GPLQQVFGTAEgllCYTRLDDPyEVIIN 347
Cdd:cd05923 245 LFATPthldALAAAAEFA----GLKLSSLRHVTFAGATMPDAVLERVNQHLpGEKVNIYGTTE---AMNSLYMR-DARTG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 348 TQGRP--LSEEDEINLADTNLQPVAPSEVGELITR--GPYTITGYYRaEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEG 423
Cdd:cd05923 317 TEMRPgfFSEVRIVRIGGSPDEALANGEEGELIVAaaADAAFTGYLN-QPEATAKKLQDGWYRTGDVGYVDPSGDVRILG 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 424 RIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKGVQRHKIPDQWL 503
Cdd:cd05923 396 RVDDMIISGGENIHPSEIERVLSRHPGVTEVVVIGVADERWGQSVTACVVPREGTLSADELDQFCRASELADFKRPRRYF 475
|
490
....*....|....*...
gi 2740590833 504 FVAYWPLTAVGKINKRQL 521
Cdd:cd05923 476 FLDELPKNAMNKVLRRQL 493
|
|
| ttLC_FACS_AlkK_like |
cd12119 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
47-521 |
4.29e-52 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.
Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 191.30 E-value: 4.29e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA--HPV--LLMPTQrahdvhalcqiarpVA 122
Cdd:cd12119 25 RYTYAEVAERARRLANALRRLGVKPGDRVATLAWNTHRHLELYYAVPGMGAvlHTInpRLFPEQ--------------IA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 123 YII---PDCIHGFDyREMAR---EVAASCPELEHIIV----DGEAEEFIPFAS-----IEDEPLNIIGPGY--GDIAVLL 185
Cdd:cd12119 91 YIInhaEDRVVFVD-RDFLPlleAIAPRLPTVEHVVVmtddAAMPEPAGVGVLayeelLAAESPEYDWPDFdeNTAAAIC 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPKLIPRTHDAyTYNFVLSARL---CAINTESVYLAVLPVAHNFILGSPgiLGTLSQGGCVLLS----DTASC 258
Cdd:cd12119 170 YTSGTTGNPKGVVYSHRS-LVLHAMAALLtdgLGLSESDVVLPVVPMFHVNAWGLP--YAAAMVGAKLVLPgpylDPASL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 259 DEampLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAE--GLLCYT 336
Cdd:cd12119 247 AE---LIEREGVTFAAGVPTVWQGLLDHLEANGRDLSSLRRVVIGGSAVPRSLIEAFEERGVRVIHAWGMTEtsPLGTVA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 RL-----DDPYEVIIN---TQGRPL-SEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQhNTVAFTTDGFYRT 407
Cdd:cd12119 324 RPpsehsNLSEDEQLAlraKQGRPVpGVELRIVDDDGRELPWDGKAVGELQVRGPWVTKSYYKNDE-ESEALTEDGWLRT 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 408 GDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQA 486
Cdd:cd12119 403 GDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGERPLAVVvLKEGATVTAEELLE 482
|
490 500 510
....*....|....*....|....*....|....*
gi 2740590833 487 FLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd12119 483 FLADK-VAKWWLPDDVVFVDEIPKTSTGKIDKKAL 516
|
|
| PRK08316 |
PRK08316 |
acyl-CoA synthetase; Validated |
35-521 |
7.37e-52 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 190.91 E-value: 7.37e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA-H-PVLLMPTqrahdvh 112
Cdd:PRK08316 24 YPDKTALVFGDRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGAvHvPVNFMLT------- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 113 alcqiARPVAYIIPDC-----IHGFDYREMAREVAASCP----ELEHIIVDGEAEE-FIPFASI---EDEPLNIIGPGYG 179
Cdd:PRK08316 97 -----GEELAYILDHSgarafLVDPALAPTAEAALALLPvdtlILSLVLGGREAPGgWLDFADWaeaGSVAEPDVELADD 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAH-----NFilgspgiLGT-LSQGGCVLLS 253
Cdd:PRK08316 172 DLAQILYTSGTESLPKGAMLTHRALIAEYVSCIVAGDMSADDIPLHALPLYHcaqldVF-------LGPyLYVGATNVIL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 254 DTASCDEAMPLIEEHKVTHLALVP----ALARlweqARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARL---------- 319
Cdd:PRK08316 245 DAPDPELILRTIEAERITSFFAPPtvwiSLLR----HPDFDTRDLSSLRKGYYGASIMPVEVLKELRERLpglrfyncyg 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 320 ----GPLQQVFGTAEGLlcyTRLDdpyeviinTQGRP-LSEEDEInlADTNLQPVAPSEVGELITRGPYTITGYYRAEQH 394
Cdd:PRK08316 321 qteiAPLATVLGPEEHL---RRPG--------SAGRPvLNVETRV--VDDDGNDVAPGEVGEIVHRSPQLMLGYWDDPEK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 395 NTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-P 473
Cdd:PRK08316 388 TAEAFR-GGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGLPDPKWIEAVTAVVvP 466
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 2740590833 474 KSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK08316 467 KAGATVTEDELIAHCRAR-LAGFKVPKRVIFVDELPRNPSGKILKREL 513
|
|
| A_NRPS_Ta1_like |
cd12116 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ... |
36-521 |
6.28e-51 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.
Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 186.73 E-value: 6.28e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALC 115
Cdd:cd12116 1 PDATAVRDDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 QIARPVAYIIPDcihgfdyrEMAREVAASCPELEHIIVDGEAeefiPFASIEDEPLNiigpgyGDIAVLLLSGGTTGTPK 195
Cdd:cd12116 81 EDAEPALVLTDD--------ALPDRLPAGLPVLLLALAAAAA----APAAPRTPVSP------DDLAYVIYTSGSTGRPK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 196 LIPRTHDAYTyNFVLS-ARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLL--SDTASCDEAMP-LIEEHKVT 271
Cdd:cd12116 143 GVVVSHRNLV-NFLHSmRERLGLGPGDRLLAVTTYA--FDISLLELLLPLLAGARVVIapRETQRDPEALArLIEAHSIT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPALarlWEQARDWEQSDLSSLRCLqVGGGRLTPELAEQVMARLGPLQQVFGTAEGLL--CYTRLDDPYEVIinTQ 349
Cdd:cd12116 220 VMQATPAT---WRMLLDAGWQGRAGLTAL-CGGEALPPDLAARLLSRVGSLWNLYGPTETTIwsTAARVTAAAGPI--PI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 350 GRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF-------YRTGDLVRIRPDGNLLVE 422
Cdd:cd12116 294 GRPLANTQ-VYVLDAALRPVPPGVPGELYIGGDGVAQGYLGRPALTAERFVPDPFagpgsrlYRTGDLVRRRADGRLEYL 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 423 GRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLhqkgvqRHKIPDQW 502
Cdd:cd12116 373 GRADGQVKIRGHRIELGEIEAALAAHPGVAQAAVVVREDGGDRRLVAYVVLKAGAAPDAAALRAHL------RATLPAYM 446
|
490 500
....*....|....*....|....
gi 2740590833 503 LFVAY-----WPLTAVGKINKRQL 521
Cdd:cd12116 447 VPSAFvrldaLPLTANGKLDRKAL 470
|
|
| PRK12583 |
PRK12583 |
acyl-CoA synthetase; Provisional |
37-533 |
2.89e-50 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 186.90 E-value: 2.89e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQ--RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHAL 114
Cdd:PRK12583 33 DREALVVRHQalRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIGAILVNINPAYRASELEYA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 CQIARPVAYIIPDCIHGFDYREMAREVA-------------ASCPELEHIIVDG--EAEEFIPFASIEDEPLNIIGPG-- 177
Cdd:PRK12583 113 LGQSGVRWVICADAFKTSDYHAMLQELLpglaegqpgalacERLPELRGVVSLApaPPPGFLAWHELQARGETVSREAla 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 178 -------YGDIAVLLLSGGTTGTPKLIPRTHdaytYNFVLSARLCAIN---TESVYLAV-LPVAHNF--ILGSpgiLGTL 244
Cdd:PRK12583 193 erqasldRDDPINIQYTSGTTGFPKGATLSH----HNILNNGYFVAESlglTEHDRLCVpVPLYHCFgmVLAN---LGCM 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 245 SQGGCVLL-SDTASCDEAMPLIEEHKVTHLALVPA--LARLWEQARDweQSDLSSLRCLQVGGGRLTPELAEQVMARL-- 319
Cdd:PRK12583 266 TVGACLVYpNEAFDPLATLQAVEEERCTALYGVPTmfIAELDHPQRG--NFDLSSLRTGIMAGAPCPIEVMRRVMDEMhm 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 320 GPLQQVFGTAEG--LLCYTRLDDPYEVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTV 397
Cdd:PRK12583 344 AEVQIAYGMTETspVSLQTTAADDLERRVETVGRTQPHL-EVKVVDPDGATVPRGEIGELCTRGYSVMKGYWNNPEATAE 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 398 AFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLP-KSI 476
Cdd:PRK12583 423 SIDEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAVADVQVFGVPDEKYGEEIVAWVRlHPG 502
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 2740590833 477 NQPDPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENTETA 533
Cdd:PRK12583 503 HAASEEELREFC-KARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMREISIEELALPV 558
|
|
| PRK07798 |
PRK07798 |
acyl-CoA synthetase; Validated |
36-528 |
1.01e-49 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 184.70 E-value: 1.01e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALC 115
Cdd:PRK07798 17 PDRVALVCGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYRYVEDELRYLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 QIARPVAyiipdCIHGFDYREMAREVAASCPELEHIIV--DGEAEEF----IPFASI----EDEPLniIGPGYGDIAVLL 185
Cdd:PRK07798 97 DDSDAVA-----LVYEREFAPRVAEVLPRLPKLRTLVVveDGSGNDLlpgaVDYEDAlaagSPERD--FGERSPDDLYLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPK-LIPRTHDAY----------TYNFVLS----ARLCAINTESVYLAVLPVAHNfiLGSPGILGTLSQGGCV 250
Cdd:PRK07798 170 YTGGTTGMPKgVMWRQEDIFrvllggrdfaTGEPIEDeeelAKRAAAGPGMRRFPAPPLMHG--AGQWAAFAALFSGQTV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 LLSDTASCD--EAMPLIEEHKVTHLALV------PALARLwEQARDWeqsDLSSLRCLQVGGGRLTPELAEQVMARLgP- 321
Cdd:PRK07798 248 VLLPDVRFDadEVWRTIEREKVNVITIVgdamarPLLDAL-EARGPY---DLSSLFAIASGGALFSPSVKEALLELL-Pn 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 322 --LQQVFGTAEGLLCYTRLDDPYEViinTQGRPLSEEDE-INLADTNLQPVAP-SEVGELITRGPYTITGYYR-AEQHNT 396
Cdd:PRK07798 323 vvLTDSIGSSETGFGGSGTVAKGAV---HTGGPRFTIGPrTVVLDEDGNPVEPgSGEIGWIARRGHIPLGYYKdPEKTAE 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 397 VAFTTDGfYR---TGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL- 472
Cdd:PRK07798 400 TFPTIDG-VRyaiPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEALKAHPDVADALVVGVPDERWGQEVVAVVq 478
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 2740590833 473 PKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAE 528
Cdd:PRK07798 479 LREGARPDLAELRAHCRSS-LAGYKVPRAIWFVDEVQRSPAGKADYRWAKEQAAER 533
|
|
| PRK03640 |
PRK03640 |
o-succinylbenzoate--CoA ligase; |
37-523 |
2.80e-47 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 176.69 E-value: 2.80e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVhaLCQ 116
Cdd:PRK03640 17 DRTAIEFEEKKVTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSREEL--LWQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 IARP-VAYIIPDcihgfdyREMAREVAASCPELEHIIVDGEAEEFIPfasIEDEPLNiigpgygDIAVLLLSGGTTGTPK 195
Cdd:PRK03640 95 LDDAeVKCLITD-------DDFEAKLIPGISVKFAELMNGPKEEAEI---QEEFDLD-------EVATIMYTSGTTGKPK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 196 LIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHnfILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLAL 275
Cdd:PRK03640 158 GVIQTYGNHWWSAVGSALNLGLTEDDCWLAAVPIFH--ISGLSILMRSVIYGMRVVLVEKFDAEKINKLLQTGGVTIISV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 276 VPA-LARLWEQARDWEQSdlSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEGLLCYTRLDDPYEVI-INTQGRPL 353
Cdd:PRK03640 236 VSTmLQRLLERLGEGTYP--SSFRCMLLGGGPAPKPLLEQCKEKGIPVYQSYGMTETASQIVTLSPEDALTkLGSAGKPL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 354 SEEdEINLADtNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSG 433
Cdd:PRK03640 314 FPC-ELKIEK-DGVVVPPFEEGEIVVKGPNVTKGYLNREDATRETFQ-DGWFKTGDIGYLDEEGFLYVLDRRSDLIISGG 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 434 EKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSiNQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAV 513
Cdd:PRK03640 391 ENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWGQVPVAFVVKS-GEVTEEELRHFCEEK-LAKYKVPKRFYFVEELPRNAS 468
|
490
....*....|
gi 2740590833 514 GKINKRQLVQ 523
Cdd:PRK03640 469 GKLLRHELKQ 478
|
|
| MCS |
cd05941 |
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ... |
37-523 |
4.49e-47 |
|
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.
Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 174.79 E-value: 4.49e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRG-IRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHdvhalc 115
Cdd:cd05941 1 DRIAIVDDGDSITYADLVARAARLANRLLALGkDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLA------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 qiarpvayiipdcihgfdyremarevaascpELEHIIVDGEAEEFIpfasiedeplniigpgygDIAVLLLSGGTTGTPK 195
Cdd:cd05941 75 -------------------------------ELEYVITDSEPSLVL------------------DPALILYTSGTTGRPK 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 196 LIPRTHDAYTYNFVLSARLCAINTESVYLAVLPV--AHNFILGspgILGTLSQGG-CVLLS----DTASCDEAMPLIeeh 268
Cdd:cd05941 106 GVVLTHANLAANVRALVDAWRWTEDDVLLHVLPLhhVHGLVNA---LLCPLFAGAsVEFLPkfdpKEVAISRLMPSI--- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 269 kvTHLALVPAL-ARLWEqarDWEQSD----------LSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE-GLLCY 335
Cdd:cd05941 180 --TVFMGVPTIyTRLLQ---YYEAHFtdpqfaraaaAERLRLMVSGSAALPVPTLEEWEAITGhTLLERYGMTEiGMALS 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 336 TRLDDpyEVIINTQGRPLSEEdEINLADTN-LQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIR 414
Cdd:cd05941 255 NPLDG--ERRPGTVGMPLPGV-QARIVDEEtGEPLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGWFKTGDLGVVD 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 415 PDGNLLVEGRIKEQINRS-GEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICAC--LPKSINQPDPAQMQAFLHQK 491
Cdd:cd05941 332 EDGYYWILGRSSVDIIKSgGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGERVVAVvvLRAGAAALSLEELKEWAKQR 411
|
490 500 510
....*....|....*....|....*....|..
gi 2740590833 492 GVqRHKIPDQWLFVAYWPLTAVGKINKRQLVQ 523
Cdd:cd05941 412 LA-PYKRPRRLILVDELPRNAMGKVNKKELRK 442
|
|
| PRK06839 |
PRK06839 |
o-succinylbenzoate--CoA ligase; |
37-524 |
4.24e-46 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 173.51 E-value: 4.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhalc 115
Cdd:PRK06839 17 DRIAIITEEEEMTYKQLHEYVSKVAAYLIYElNVKKGERIAILSQNSLEYIVLLFAIAKVEC------------------ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 qIARPVAYIIPDCIHGFDYREMAREVAASCPELEHIIVDGEAEEFI-PFASIED-------EPLNIIGPGYGDIAVLLLS 187
Cdd:PRK06839 79 -IAVPLNIRLTENELIFQLKDSGTTVLFVEKTFQNMALSMQKVSYVqRVISITSlkeiedrKIDNFVEKNESASFIICYT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 188 GGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHnfiLGSPGI--LGTLSQGGCVLLSDTASCDEAMPLI 265
Cdd:PRK06839 158 SGTTGKPKGAVLTQENMFWNALNNTFAIDLTMHDRSIVLLPLFH---IGGIGLfaFPTLFAGGVIIVPRKFEPTKALSMI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 266 EEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAE-GLLCYTRLDDPYEV 344
Cdd:PRK06839 235 EKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFYNGGAPCPEELMREFIDRGFLFGQGFGMTEtSPTVFMLSEEDARR 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 345 IINTQGRPLSEeDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHnTVAFTTDGFYRTGDLVRIRPDGNLLVEGR 424
Cdd:PRK06839 315 KVGSIGKPVLF-CDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDA-TEETIQDGWLCTGDLARVDEDGFVYIVGR 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 425 IKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGE-RICACLPKSINQPDPAQMQAFLHQKgVQRHKIPDQWL 503
Cdd:PRK06839 393 KKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEiPIAFIVKKSSSVLIEKDVIEHCRLF-LAKYKIPKEIV 471
|
490 500
....*....|....*....|.
gi 2740590833 504 FVAYWPLTAVGKINKRQLVQM 524
Cdd:PRK06839 472 FLKELPKNATGKIQKAQLVNQ 492
|
|
| PRK07529 |
PRK07529 |
AMP-binding domain protein; Validated |
33-521 |
4.55e-46 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 175.91 E-value: 4.55e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 33 SIWGNKTALIY--------HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLG-AHPV--L 101
Cdd:PRK07529 36 ARHPDAPALSFlldadpldRPETWTYAELLADVTRTANLLHSLGVGPGDVVAFLLPNLPETHFALWGGEAAGiANPInpL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 102 LMPTQRAHDVHAlcQIARPVAYIIPDciHGFDYREMAREVAASCPELEHII-VDG-----EAEEFIPFASIEDEPLNIIG 175
Cdd:PRK07529 116 LEPEQIAELLRA--AGAKVLVTLGPF--PGTDIWQKVAEVLAALPELRTVVeVDLarylpGPKRLAVPLIRRKAHARILD 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 176 ------------------PGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILgS 237
Cdd:PRK07529 192 fdaelarqpgdrlfsgrpIGPDDVAAYFHTGGTTGMPKLAQHTHGNEVANAWLGALLLGLGPGDTVFCGLPLFHVNAL-L 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 238 PGILGTLSQGGCVLLS------DTASCDEAMPLIEEHKVTHLALVP-ALARLWEQARDweQSDLSSLRCLQVGGGRLTPE 310
Cdd:PRK07529 271 VTGLAPLARGAHVVLAtpqgyrGPGVIANFWKIVERYRINFLSGVPtVYAALLQVPVD--GHDISSLRYALCGAAPLPVE 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 311 LAEQVMARLG-PLQQVFGTAEGLlCYTRLDDPY-EVIINTQGRPLSEED----EINLADTNLQPVAPSEVGELITRGPYT 384
Cdd:PRK07529 349 VFRRFEAATGvRIVEGYGLTEAT-CVSSVNPPDgERRIGSVGLRLPYQRvrvvILDDAGRYLRDCAVDEVGVLCIAGPNV 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 385 ITGYYRAEqHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELL 464
Cdd:PRK07529 428 FSGYLEAA-HNKGLWLEDGWLNTGDLGRIDADGYFWLTGRAKDLIIRGGHNIDPAAIEEALLRHPAVALAAAVGRPDAHA 506
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 465 GERICACL---PKSinQPDPAQMQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK07529 507 GELPVAYVqlkPGA--SATEAELLAFARDHIAERAAVPKHVRILDALPKTAVGKIFKPAL 564
|
|
| OSB_CoA_lg |
cd05912 |
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ... |
48-523 |
5.63e-46 |
|
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.
Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 170.99 E-value: 5.63e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHdvhalcqiarpvayiipd 127
Cdd:cd05912 2 YTFAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPN------------------ 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 cihgfdyrEMAREvaascpelehiivdgeaeefipfasIEDeplniIGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYN 207
Cdd:cd05912 64 --------ELAFQ-------------------------LKD-----SDVKLDDIATIMYTSGTTGKPKGVQQTFGNHWWS 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 208 FVLSARLCAINTESVYLAVLPVAHnfILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPA-LARLWEQa 286
Cdd:cd05912 106 AIGSALNLGLTEDDNWLCALPLFH--ISGLSILMRSVIYGMTVYLVDKFDAEQVLHLINSGKVTIISVVPTmLQRLLEI- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 287 rdWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFG---TAEGLLCYTRLDDPYEviINTQGRPLSEEdEINLAD 363
Cdd:cd05912 183 --LGEGYPNNLRCILLGGGPAPKPLLEQCKEKGIPVYQSYGmteTCSQIVTLSPEDALNK--IGSAGKPLFPV-ELKIED 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 364 TNlqpVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVET 443
Cdd:cd05912 258 DG---QPPYEVGEILLKGPNVTKGYLNRPDATEESFE-NGWFKTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEE 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 444 LLLQHPDIDDTVVIAVPDELLGERICACLpkSINQP-DPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLV 522
Cdd:cd05912 334 VLLSHPAIKEAGVVGIPDDKWGQVPVAFV--VSERPiSEEELIAYC-SEKLAKYKVPKKIYFVDELPRTASGKLLRHELK 410
|
.
gi 2740590833 523 Q 523
Cdd:cd05912 411 Q 411
|
|
| A_NRPS_AB3403-like |
cd17646 |
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ... |
39-521 |
6.08e-45 |
|
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 169.76 E-value: 6.08e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIA 118
Cdd:cd17646 15 PAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPGYPADRLAYMLADA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 119 RPvAYIIPDcihgfdyremAREVAASCPELEHIIVDGEAeefipFASIEDEPLnIIGPGYGDIAVLLLSGGTTGTPKLIP 198
Cdd:cd17646 95 GP-AVVLTT----------ADLAARLPAGGDVALLGDEA-----LAAPPATPP-LVPPRPDNLAYVIYTSGSTGRPKGVM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 199 RTHDAytynfvLSARLCAINTESVYLAVLPVAHNFILGSP----GILGTLSQGGCVLLsdtascdeAMP----------- 263
Cdd:cd17646 158 VTHAG------IVNRLLWMQDEYPLGPGDRVLQKTPLSFDvsvwELFWPLVAGARLVV--------ARPgghrdpaylaa 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 264 LIEEHKVTHLALVPALARLWEQARDWEQsdLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLL--CYTRLDD 340
Cdd:cd17646 224 LIREHGVTTCHFVPSMLRVFLAEPAAGS--CASLRRVFCSGEALPPELAARFLALPGaELHNLYGPTEAAIdvTHWPVRG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 PYEVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRIR 414
Cdd:cd17646 302 PAETPSVPIGRPVPNT-RLYVLDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFgpgsrmYRTGDLARWR 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 415 PDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSINQPDPAQMQAFLHQKg 492
Cdd:cd17646 381 PDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARAAPAGAARLVGyvVPAAGAAGPDTAALRAHLAER- 459
|
490 500
....*....|....*....|....*....
gi 2740590833 493 VQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17646 460 LPEYMVPAAFVVLDALPLTANGKLDRAAL 488
|
|
| PRK13571 |
PRK13571 |
anthranilate synthase component I; Provisional |
716-971 |
1.03e-44 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184152 [Multi-domain] Cd Length: 506 Bit Score: 169.43 E-value: 1.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 716 TAKNYQDNVANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGRQANTPARSFFLR------DGDFSAYGFSPETVVE 789
Cdd:PRK13571 228 TVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTADPLDVYRVLRVTNPSPYMYLLRvpnsdgGTDFSIVGSSPEALVT 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 790 AEGsGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAIcERGS-VQHL 868
Cdd:PRK13571 308 VTD-GRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRNDLGRVCRPGTVRVVDFSHI-ERYShVMHL 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 869 ASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCW 948
Cdd:PRK13571 386 VSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGVVGYLDFAGDADTAIAIRTALMRDGTAY 465
|
250 260
....*....|....*....|...
gi 2740590833 949 LQAGAGLVRNSRPEREWQETCEK 971
Cdd:PRK13571 466 VQAGGGVVADSDPDYEDNEARNK 488
|
|
| MACS_like |
cd05972 |
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ... |
48-521 |
1.48e-44 |
|
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.
Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 167.13 E-value: 1.48e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhalcqIARPvayiipd 127
Cdd:cd05972 1 WSFRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGA-------------------VYVP------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 CIHGFDYREMAREVAASCPELehIIVDGEaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKLIPRTHdaytyn 207
Cdd:cd05972 55 LTTLLGPKDIEYRLEAAGAKA--IVTDAE-----------------------DPALIYFTSGTTGLPKGVLHTH------ 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 208 fvlSARLCAINTESVYLAVLPVAHNFILGSPG--------ILGTLSQGGCVLLSDTASCD--EAMPLIEEHKVTHLALVP 277
Cdd:cd05972 104 ---SYPLGHIPTAAYWLGLRPDDIHWNIADPGwakgawssFFGPWLLGATVFVYEGPRFDaeRILELLERYGVTSFCGPP 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 278 ALARLWEQArDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE-GLLCYTRLDDPyeVIINTQGRPLSE 355
Cdd:cd05972 181 TAYRMLIKQ-DLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGlPIRDGYGQTEtGLTVGNFPDMP--VKPGSMGRPTPG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 356 EDeINLADTNLQPVAPSEVGEL-ITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGE 434
Cdd:cd05972 258 YD-VAIIDDDGRELPPGEEGDIaIKLPPPGLFLGYVGDPEKTEASIRGDYYLTGDRAYRDEDGYFWFVGRADDIIKSSGY 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 435 KISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKGVQR---HKIPDQWLFVAYWPLT 511
Cdd:cd05972 337 RIGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSGYEPSEELAEELQGHVKKVlapYKYPREIEFVEELPKT 416
|
490
....*....|
gi 2740590833 512 AVGKINKRQL 521
Cdd:cd05972 417 ISGKIRRVEL 426
|
|
| FACL_like_2 |
cd05917 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
189-521 |
2.20e-44 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 164.37 E-value: 2.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 189 GTTGTPKLIPRTHdaytYNFVLSARLCAIN---TESVYLAV-LPVAHNFilGSP-GILGTLSQGG-CVLLSDTASCDEAM 262
Cdd:cd05917 12 GTTGSPKGATLTH----HNIVNNGYFIGERlglTEQDRLCIpVPLFHCF--GSVlGVLACLTHGAtMVFPSPSFDPLAVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 263 PLIEEHKVTHLALVPAL--ARLWEQarDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG--PLQQVFGTAEG--LLCYT 336
Cdd:cd05917 86 EAIEKEKCTALHGVPTMfiAELEHP--DFDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNmkDVTIAYGMTETspVSTQT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 RLDDPYEVIINTQGRPLSE-EDEINLADTNLQPvAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRP 415
Cdd:cd05917 164 RTDDSIEKRVNTVGRIMPHtEAKIVDPEGGIVP-PVGVPGELCIRGYSVMKGYWNDPEKTAEAIDGDGWLHTGDLAVMDE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 416 DGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQ 494
Cdd:cd05917 243 DGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGEEVCAWIrLKEGAELTEEDIKAYCKGK-IA 321
|
330 340
....*....|....*....|....*..
gi 2740590833 495 RHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05917 322 HYKVPRYVFFVDEFPLTVSGKIQKFKL 348
|
|
| BCL_4HBCL |
cd05959 |
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ... |
36-521 |
3.48e-44 |
|
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.
Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 167.93 E-value: 3.48e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPV----LLMPTQrahdv 111
Cdd:cd05959 18 GDKTAFIDDAGSLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVpvntLLTPDD----- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 112 halcqiarpVAYIIPD------CIHGFDYREMAREVAASCPELEHIIVDGEAEEFIPFASIEDEP------LNIIGPGYG 179
Cdd:cd05959 93 ---------YAYYLEDsrarvvVVSGELAPVLAAALTKSEHTLVVLIVSGGAGPEAGALLLAELVaaeaeqLKPAATHAD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSAR-LCAINTESVYLAVLPVAHNFILGSpGILGTLSQGG-CVLLSDTAS 257
Cdd:cd05959 164 DPAFWLYSSGSTGRPKGVVHLHADIYWTAELYARnVLGIREDDVCFSAAKLFFAYGLGN-SLTFPLSVGAtTVLMPERPT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 258 CDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGpLQQV--FGTAEGLLCY 335
Cdd:cd05959 243 PAAVFKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLCVSAGEALPAEVGERWKARFG-LDILdgIGSTEMLHIF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 336 TRlDDPYEVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYrAEQHNTVAFTTDGFYRTGDLVRIRP 415
Cdd:cd05959 322 LS-NRPGRVRYGTTGKPVPGY-EVELRDEDGGDVADGEPGELYVRGPSSATMYW-NNRDKTRDTFQGEWTRTGDKYVRDD 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 416 DGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQP---DPAQMQAFLHQK 491
Cdd:cd05959 399 DGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDGLTKPKAFVvLRPGYEDseaLEEELKEFVKDR 478
|
490 500 510
....*....|....*....|....*....|
gi 2740590833 492 gVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05959 479 -LAPYKYPRWIVFVDELPKTATGKIQRFKL 507
|
|
| PRK07788 |
PRK07788 |
acyl-CoA synthetase; Validated |
37-524 |
5.89e-44 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 168.18 E-value: 5.89e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL----MPTQRA---- 108
Cdd:PRK07788 64 DRAALIDERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLntgfSGPQLAevaa 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 109 -HDVHALC---QIARPVAYIIPD---CIHGFDYREMAREVAASCPELEHIIVDGEAEEFIPFASiedeplniigPGygdi 181
Cdd:PRK07788 144 rEGVKALVyddEFTDLLSALPPDlgrLRAWGGNPDDDEPSGSTDETLDDLIAGSSTAPLPKPPK----------PG---- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 182 AVLLLSGGTTGTPKLIPRTH-DAYTynfVLSARLCAI--NTESVYLAVLPVAH-----NFILGspgilgtLSQGGCVLLS 253
Cdd:PRK07788 210 GIVILTSGTTGTPKGAPRPEpSPLA---PLAGLLSRVpfRAGETTLLPAPMFHatgwaHLTLA-------MALGSTVVLR 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 254 DTASCDEAMPLIEEHKVTHLALVPA-LARLWEQARDWEQS-DLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAE 330
Cdd:PRK07788 280 RRFDPEATLEDIAKHKATALVVVPVmLSRILDLGPEVLAKyDTSSLKIIFVSGSALSPELATRALEAFGPvLYNLYGSTE 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 331 glLCYTRLDDPYEVIIN--TQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVafttDGFYRTG 408
Cdd:PRK07788 360 --VAFATIATPEDLAEApgTVGRPPKGV-TVKILDENGNEVPRGVVGRIFVGNGFPFEGYTDGRDKQII----DGLLSSG 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 409 DLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA-CLPKSINQPDPAQMQAF 487
Cdd:PRK07788 433 DVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVDDEEFGQRLRAfVVKAPGAALDEDAIKDY 512
|
490 500 510
....*....|....*....|....*....|....*..
gi 2740590833 488 LHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQM 524
Cdd:PRK07788 513 VRDN-LARYKVPRDVVFLDELPRNPTGKVLKRELREM 548
|
|
| BCL_like |
cd05919 |
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ... |
38-521 |
8.31e-44 |
|
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.
Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 165.33 E-value: 8.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 38 KTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVhalcqi 117
Cdd:cd05919 1 KTAFYAADRSVTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDY------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 arpvAYIIPDCihgfdyreMAREVaascpelehiIVDGEaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKLI 197
Cdd:cd05919 75 ----AYIARDC--------EARLV----------VTSAD-----------------------DIAYLLYSSGTTGPPKGV 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 198 PRTH-DAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSpGILGTLSQGGCVLLSDTA-SCDEAMPLIEEHKVTHLAL 275
Cdd:cd05919 110 MHAHrDPLLFADAMAREALGLTPGDRVFSSAKMFFGYGLGN-SLWFPLAVGASAVLNPGWpTAERVLATLARFRPTVLYG 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 276 VPAL-ARLWEQArDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRlDDPYEVIINTQGRPL 353
Cdd:cd05919 189 VPTFyANLLDSC-AGSPDALRSLRLCVSAGEALPRGLGERWMEHFGgPILDGIGATEVGHIFLS-NRPGAWRLGSTGRPV 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 354 sEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQhNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSG 433
Cdd:cd05919 267 -PGYEIRLVDEEGHTIPPGEEGDLLVRGPSAAVGYWNNPE-KSRATFNGGWYRTGDKFCRDADGWYTHAGRADDMLKVGG 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 434 EKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAfLHQKGVQR---HKIPDQWLFVAYWP 509
Cdd:cd05919 345 QWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVvLKSPAAPQESLARD-IHRHLLERlsaHKVPRRIAFVDELP 423
|
490
....*....|..
gi 2740590833 510 LTAVGKINKRQL 521
Cdd:cd05919 424 RTATGKLQRFKL 435
|
|
| FAA1 |
COG1022 |
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; |
22-493 |
8.63e-44 |
|
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 168.74 E-value: 8.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 22 KTLDQQLAGWSSIWGNKTALIYHE----QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA 97
Cdd:COG1022 11 DTLPDLLRRRAARFPDRVALREKEdgiwQSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADLAILAAGA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 98 HPVLLMPTQRAHDvhalcqiarpVAYIIPDC------IHGFDYREMAREVAASCPELEHIIV-DGEAEE----FIPFASI 166
Cdd:COG1022 91 VTVPIYPTSSAEE----------VAYILNDSgakvlfVEDQEQLDKLLEVRDELPSLRHIVVlDPRGLRddprLLSLDEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 167 EDEPLNIIGPGY----------GDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNF--I 234
Cdd:COG1022 161 LALGREVADPAElearraavkpDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGDRTLSFLPLAHVFerT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 235 LGspgiLGTLSQGGCVLLsdTASCDEAMPLIEEHKVTHLALVPalaRLWE--------------------------QARD 288
Cdd:COG1022 241 VS----YYALAAGATVAF--AESPDTLAEDLREVKPTFMLAVP---RVWEkvyagiqakaeeagglkrklfrwalaVGRR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 289 WEQSDLSS-----------------------------LRCLQVGGGRLTPELAEqVMARLG-PLQQVFGTAE--GLLCYT 336
Cdd:COG1022 312 YARARLAGkspslllrlkhaladklvfsklrealggrLRFAVSGGAALGPELAR-FFRALGiPVLEGYGLTEtsPVITVN 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 RLDDpyeVIINTQGRPLsEEDEINLADTnlqpvapsevGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPD 416
Cdd:COG1022 391 RPGD---NRIGTVGPPL-PGVEVKIAED----------GEILVRGPNVMKGYYKNPEATAEAFDADGWLHTGDIGELDED 456
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 417 GNLLVEGRIKEQI-NRSGEKISTLEVETLLLQHPDIDDTVVIAvpDellGERICACLpksINqPDPAQMQAFLHQKGV 493
Cdd:COG1022 457 GFLRITGRKKDLIvTSGGKNVAPQPIENALKASPLIEQAVVVG--D---GRPFLAAL---IV-PDFEALGEWAEENGL 525
|
|
| PRK05852 |
PRK05852 |
fatty acid--CoA ligase family protein; |
39-523 |
3.23e-43 |
|
fatty acid--CoA ligase family protein;
Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 165.83 E-value: 3.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQR--LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQ 116
Cdd:PRK05852 33 PALVVTADRiaISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPIAEQRVRSQ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 IARPVAYIIPDCIHGfdyrEMAREVAASCPELEHIIVDGEAEEFIPF----ASIEDEPLNIIGPGYG-DIAVLLLSGGTT 191
Cdd:PRK05852 113 AAGARVVLIDADGPH----DRAEPTTRWWPLTVNVGGDSGPSGGTLSvhldAATEPTPATSTPEGLRpDDAMIMFTGGTT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 192 GTPKLIPRTHdaytYNFVLSAR-LCA---INTESVYLAVLPVAHNFILGSpGILGTLSQGGCVLLSDTA--SCDEAMPLI 265
Cdd:PRK05852 189 GLPKMVPWTH----ANIASSVRaIITgyrLSPRDATVAVMPLYHGHGLIA-ALLATLASGGAVLLPARGrfSAHTFWDDI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 266 EEHKVTHLALVPALARLWEQARDWEQSDL--SSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE--------GLLC 334
Cdd:PRK05852 264 KAVGATWYTAVPTIHQILLERAATEPSGRkpAALRFIRSCSAPLTAETAQALQTEFAaPVVCAFGMTEathqvtttQIEG 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 YTRLDDPyEVIINTQGRplSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYrAEQHNTVAFTTDGFYRTGDLVRIR 414
Cdd:PRK05852 344 IGQTENP-VVSTGLVGR--STGAQIRIVGSDGLPLPAGAVGEVWLRGTTVVRGYL-GDPTITAANFTDGWLRTGDLGSLS 419
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 415 PDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLhQKGV 493
Cdd:PRK05852 420 AAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPDQLYGEAVAAVIvPRESAPPTAEELVQFC-RERL 498
|
490 500 510
....*....|....*....|....*....|
gi 2740590833 494 QRHKIPDQWLFVAYWPLTAVGKINKRQLVQ 523
Cdd:PRK05852 499 AAFEIPASFQEASGLPHTAKGSLDRRAVAE 528
|
|
| A_NRPS_Cytc1-like |
cd17643 |
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ... |
39-521 |
4.19e-43 |
|
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 163.63 E-value: 4.19e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPtqrahdvhalcqiA 118
Cdd:cd17643 4 VAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDP-------------A 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 119 RPVAYIipdcihgfdyREMAREVAASCpelehIIVDGEaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKLIP 198
Cdd:cd17643 71 YPVERI----------AFILADSGPSL-----LLTDPD-----------------------DLAYVIYTSGSTGRPKGVV 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 199 RTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSpgILGTLSQGGCVLL--SDTASCDEAMP-LIEEHKVTHLAL 275
Cdd:cd17643 113 VSHANVLALFAATQRWFGFNEDDVWTLFHSYAFDFSVWE--IWGALLHGGRLVVvpYEVARSPEDFArLLRDEGVTVLNQ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 276 VPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPelaeqvmARLGPLQQVFGTAEgllcyTRLDDPY---EVIINTQGRP 352
Cdd:cd17643 191 TPSAFYQLVEAADRDGRDPLALRYVIFGGEALEA-------AMLRPWAGRFGLDR-----PQLVNMYgitETTVHVTFRP 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 353 LSEED----------------EINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF-------YRTGD 409
Cdd:cd17643 259 LDAADlpaaaaspigrplpglRVYVLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERFVANPFggpgsrmYRTGD 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 410 LVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFL 488
Cdd:cd17643 339 LARRLPDGELEYLGRADEQVKIRGFRIELGEIEAALATHPSVRDAAVIVREDEPGDTRLVAYVvADDGAAADIAELRALL 418
|
490 500 510
....*....|....*....|....*....|...
gi 2740590833 489 HQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17643 419 KEL-LPDYMVPARYVPLDALPLTVNGKLDRAAL 450
|
|
| PRK09088 |
PRK09088 |
acyl-CoA synthetase; Validated |
46-521 |
4.28e-42 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 161.51 E-value: 4.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPvAYII 125
Cdd:PRK09088 21 RRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSASELDALLQDAEP-RLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 PDcihgfdyremaREVAASCPE---LEHIIVDGEAEEFIPFASIEDEPLNIIgpgygdiavlLLSGGTTGTPK---LIPR 199
Cdd:PRK09088 100 GD-----------DAVAAGRTDvedLAAFIASADALEPADTPSIPPERVSLI----------LFTSGTSGQPKgvmLSER 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 THDAYTYNFvlsARLCAINTESVYLAVLPVAHnfILG-SPGILGTLSQGGCVLLSDTASCDEAMPLIEEHK--VTHLALV 276
Cdd:PRK09088 159 NLQQTAHNF---GVLGRVDAHSSFLCDAPMFH--IIGlITSVRPVLAVGGSILVSNGFEPKRTLGRLGDPAlgITHYFCV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 277 PALARLWEQARDWEQSDLSSLRCLQVGGGrltPELAEQVMARLG---PLQQVFGTAEGLLCYTRLDDPyEVIINTQGRP- 352
Cdd:PRK09088 234 PQMAQAFRAQPGFDAAALRHLTALFTGGA---PHAAEDILGWLDdgiPMVDGFGMSEAGTVFGMSVDC-DVIRAKAGAAg 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 353 -LSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINR 431
Cdd:PRK09088 310 iPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQATARAFTGDGWFRTGDIARRDADGFFWVVDRKKDMFIS 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 432 SGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGE-RICACLPKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPL 510
Cdd:PRK09088 390 GGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEvGYLAIVPADGAPLDLERIRSHLSTR-LAKYKVPKHLRLVDALPR 468
|
490
....*....|.
gi 2740590833 511 TAVGKINKRQL 521
Cdd:PRK09088 469 TASGKLQKARL 479
|
|
| A_NRPS_TlmIV_like |
cd12114 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ... |
37-521 |
6.84e-42 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.
Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 160.51 E-value: 6.84e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAhdvhalcq 116
Cdd:cd12114 2 DATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPA-------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 iARpVAYIIPDCIHGFDyremareVAASCPELEHIIVDGEAEEFIPFASIEDEPLNiIGPGYGDIAVLLLSGGTTGTPKL 196
Cdd:cd12114 74 -AR-REAILADAGARLV-------LTDGPDAQLDVAVFDVLILDLDALAAPAPPPP-VDVAPDDLAYVIFTSGSTGTPKG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAyTYNFVLS-ARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLLSDTASCDEA---MPLIEEHKVTH 272
Cdd:cd12114 144 VMISHRA-ALNTILDiNRRFAVGPDDRVLALSSLS--FDLSVYDIFGALSAGATLVLPDEARRRDPahwAELIERHGVTL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVmARLGPLQQVF---GTAEGLL--CYTRLDD------- 340
Cdd:cd12114 221 WNSVPALLEMLLDVLEAAQALLPSLRLVLLSGDWIPLDLPARL-RALAPDARLIslgGATEASIwsIYHPIDEvppdwrs 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 -PYeviintqGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDG----FYRTGDLVRIRP 415
Cdd:cd12114 300 iPY-------GRPLANQ-RYRVLDPRGRDCPDWVPGELWIGGRGVALGYLGDPELTAARFVTHPdgerLYRTGDLGRYRP 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 416 DGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDEllGERICACLPKSINQPDPAQMQAfLHQKGVQR 495
Cdd:cd12114 372 DGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVLGDP--GGKRLAAFVVPDNDGTPIAPDA-LRAFLAQT 448
|
490 500
....*....|....*....|....*....
gi 2740590833 496 ---HKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd12114 449 lpaYMIPSRVIALEALPLTANGKVDRAAL 477
|
|
| PRK13391 |
PRK13391 |
acyl-CoA synthetase; Provisional |
47-522 |
8.53e-42 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 161.01 E-value: 8.53e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDvhalcqiarpVAYIIP 126
Cdd:PRK13391 24 VVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPAE----------AAYIVD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 DC-----IHGFDYREMAREVAASCPELEHIIV---DGEAEEFIPFAS---------IEDEPLNiigpgygdiAVLLLSGG 189
Cdd:PRK13391 94 DSgaralITSAAKLDVARALLKQCPGVRHRLVldgDGELEGFVGYAEavaglpatpIADESLG---------TDMLYSSG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 190 TTGTPKLIPR------THDAYTYNFVLsARLCAINTESVYLAVLPVAHNFILGSPGIlgTLSQGGCVLLSDTASCDEAMP 263
Cdd:PRK13391 165 TTGRPKGIKRplpeqpPDTPLPLTAFL-QRLWGFRSDMVYLSPAPLYHSAPQRAVML--VIRLGGTVIVMEHFDAEQYLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 264 LIEEHKVTHLALVPAL----ARLWEQARDweQSDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEGLLcYTRL 338
Cdd:PRK13391 242 LIEEYGVTHTQLVPTMfsrmLKLPEEVRD--KYDLSSLEVAIHAAAPCPPQVKEQMIDWWGPiIHEYYAATEGLG-FTAC 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 339 DDPyEVIIN--TQGRPLSeeDEINLADTNLQPVAPSEVGELITRG--PYtitgyyraEQHNTVAFTT-----DGFYRT-G 408
Cdd:PRK13391 319 DSE-EWLAHpgTVGRAMF--GDLHILDDDGAELPPGEPGTIWFEGgrPF--------EYLNDPAKTAearhpDGTWSTvG 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 409 DLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPA---QM 484
Cdd:PRK13391 388 DIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDLGEEVKAVVqPVDGVDPGPAlaaEL 467
|
490 500 510
....*....|....*....|....*....|....*...
gi 2740590833 485 QAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLV 522
Cdd:PRK13391 468 IAFCRQR-LSRQKCPRSIDFEDELPRLPTGKLYKRLLR 504
|
|
| A_NRPS_VisG_like |
cd17651 |
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ... |
40-521 |
1.19e-41 |
|
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 160.20 E-value: 1.19e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIAR 119
Cdd:cd17651 13 ALVAEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYPAERLAFMLADAG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 120 PVAYIIPDcihGFDYREMAREVAASCPELEHIIVDGEAEEFIPfasiedeplniigPGYGDIAVLLLSGGTTGTPKLIPR 199
Cdd:cd17651 93 PVLVLTHP---ALAGELAVELVAVTLLDQPGAAAGADAEPDPA-------------LDADDLAYVIYTSGSTGRPKGVVM 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 THDAYTyNFVL-SARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGC-VLLSDTASCDEA--MPLIEEHKVTHLAL 275
Cdd:cd17651 157 PHRSLA-NLVAwQARASSLGPGARTLQFAGLG--FDVSVQEIFSTLCAGATlVLPPEEVRTDPPalAAWLDEQRISRVFL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 276 VPALARLWEQARDWEQSDLSSLRCLQVGGGRL--TPEL----AEQVMARL----GPLQQVFGTAEGL-LCYTRLDDPyev 344
Cdd:cd17651 234 PTVALRALAEHGRPLGVRLAALRYLLTGGEQLvlTEDLrefcAGLPGLRLhnhyGPTETHVVTALSLpGDPAAWPAP--- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 345 iiNTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRIRPDGN 418
Cdd:cd17651 311 --PPIGRPIDNT-RVYVLDAALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPDPFvpgarmYRTGDLARWLPDGE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 419 LLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQRHK 497
Cdd:cd17651 388 LEFLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLAREDRPGEKRLVAYVvGDPEAPVDAAELRAALATH-LPEYM 466
|
490 500
....*....|....*....|....
gi 2740590833 498 IPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17651 467 VPSAFVLLDALPLTPNGKLDRRAL 490
|
|
| A_NRPS_Bac |
cd17655 |
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ... |
37-521 |
1.37e-41 |
|
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 159.80 E-value: 1.37e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRAHdvha 113
Cdd:cd17655 12 DHTAVVFEDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIdpdYPEERIQ---- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 lcqiarpvaYIIPDCihGFDYREMAREVAASCPELEHIIVDGEAEefipFASIEDEPLNIIGpGYGDIAVLLLSGGTTGT 193
Cdd:cd17655 88 ---------YILEDS--GADILLTQSHLQPPIAFIGLIDLLDEDT----IYHEESENLEPVS-KSDDLAYVIYTSGSTGK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 194 PKLIPRTHDAYTyNFVLSARLCAINTESVYLAVLpVAHNFILGSPGILGTLSQGGCVLLSDTASCDEAMPLIE---EHKV 270
Cdd:cd17655 152 PKGVMIEHRGVV-NLVEWANKVIYQGEHLRVALF-ASISFDASVTEIFASLLSGNTLYIVRKETVLDGQALTQyirQNRI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 271 THLALVPALARLWEQARDWEQSdlsSLRCLQVGGGRLTPELAEQVMARLGP---LQQVFGTAEGLLCYTRLddPYEVIIN 347
Cdd:cd17655 230 TIIDLTPAHLKLLDAADDSEGL---SLKHLIVGGEALSTELAKKIIELFGTnptITNAYGPTETTVDASIY--QYEPETD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 348 TQ-----GRPLSEeDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRIRPD 416
Cdd:cd17655 305 QQvsvpiGKPLGN-TRIYILDQYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKFVDDPFvpgermYRTGDLARWLPD 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 417 GNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLpKSINQPDPAQMQAFLhQKGVQRH 496
Cdd:cd17655 384 GNIEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKEAVVIARKDEQGQNYLCAYI-VSEKELPVAQLREFL-ARELPDY 461
|
490 500
....*....|....*....|....*
gi 2740590833 497 KIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17655 462 MIPSYFIKLDEIPLTPNGKVDRKAL 486
|
|
| OSB_MenE-like |
cd17630 |
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ... |
180-525 |
1.39e-41 |
|
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.
Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 155.57 E-value: 1.39e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAH---------NFILGSPGILGTLSQGgcv 250
Cdd:cd17630 1 RLATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGDSWLLSLPLYHvgglailvrSLLAGAELVLLERNQA--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 LLSDTASCDeamplieehkVTHLALVPA-LARLWEqaRDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTA 329
Cdd:cd17630 78 LAEDLAPPG----------VTHVSLVPTqLQRLLD--SGQGPAALKSLRAVLLGGAPIPPELLERAADRGIPLYTTYGMT 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 330 E--GLLCYTRLDDPYEviiNTQGRPLsEEDEINLADTnlqpvapsevGELITRGPYTITGYYRAEQHNtvAFTTDGFYRT 407
Cdd:cd17630 146 EtaSQVATKRPDGFGR---GGVGVLL-PGRELRIVED----------GEIWVGGASLAMGYLRGQLVP--EFNEDGWFTT 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 408 GDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICAcLPKSINQPDPAQMQAF 487
Cdd:cd17630 210 KDLGELHADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVA-VIVGRGPADPAELRAW 288
|
330 340 350
....*....|....*....|....*....|....*...
gi 2740590833 488 LHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMA 525
Cdd:cd17630 289 LKDK-LARFKLPKRIYPVPELPRTGGGKVDRRALRAWL 325
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
37-534 |
1.54e-41 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 166.19 E-value: 1.54e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQ 116
Cdd:COG1020 491 DAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPAYPAERLAYMLE 570
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 IARPVAYIipdcihgfdyreMAREVAASCPELEHIIVDGEAEEFIPFASieDEPLNIIGPGygDIAVLLLSGGTTGTPK- 195
Cdd:COG1020 571 DAGARLVL------------TQSALAARLPELGVPVLALDALALAAEPA--TNPPVPVTPD--DLAYVIYTSGSTGRPKg 634
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 196 -LIprTHDAYTyNFVLS-ARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGC-VLLSDTASCD-EAM-PLIEEHKV 270
Cdd:COG1020 635 vMV--EHRALV-NLLAWmQRRYGLGPGDRVLQFASLS--FDASVWEIFGALLSGATlVLAPPEARRDpAALaELLARHRV 709
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 271 THLALVPALARLWeqaRDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQV--FGTAEGLL--CYTRLDDPYE--- 343
Cdd:COG1020 710 TVLNLTPSLLRAL---LDAAPEALPSLRLVLVGGEALPPELVRRWRARLPGARLVnlYGPTETTVdsTYYEVTPPDAdgg 786
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 -VIIntqGRPLSeedeiNLA----DTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF-------YRTGDLV 411
Cdd:COG1020 787 sVPI---GRPIA-----NTRvyvlDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAERFVADPFgfpgarlYRTGDLA 858
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 412 RIRPDGNLLVEGRIKEQInrsgeKISTL-----EVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQA 486
Cdd:COG1020 859 RWLPDGNLEFLGRADDQV-----KIRGFrielgEIEAALLQHPGVREAVVVAREDAPGDKRLVAYVVPEAGAAAAAALLR 933
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 2740590833 487 FLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENTETAE 534
Cdd:COG1020 934 LALALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAAAAAAAAAA 981
|
|
| BACL_like |
cd05929 |
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ... |
47-522 |
2.57e-41 |
|
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.
Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 158.69 E-value: 2.57e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRAHDV-HALCQIARPVA 122
Cdd:cd05929 17 LLLLDVYSIALNRNARAAAAEGVWIADGVYIYLINSILTVFAAAAAWKCGACPAYKssrAPRAEACAIiEIKAAALVCGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 123 YIIPDCIHGF-DYREmarevaascpelehiivdgeAEEFIPFASIEDEplniiGPGYgdiaVLLLSGGTTGTPKLIPRTH 201
Cdd:cd05929 97 FTGGGALDGLeDYEA--------------------AEGGSPETPIEDE-----AAGW----KMLYSGGTTGRPKGIKRGL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 202 DAYTYN---FVLSARLCAINTESVYLAVLPVAHNfilgSPGI--LGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALV 276
Cdd:cd05929 148 PGGPPDndtLMAAALGFGPGADSVYLSPAPLYHA----APFRwsMTALFMGGTLVLMEKFDPEEFLRLIERYRVTFAQFV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 277 PA----LARLWEQARDWEqsDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEGL-LCYTRLDD----PYEVii 346
Cdd:cd05929 224 PTmfvrLLKLPEAVRNAY--DLSSLKRVIHAAAPCPPWVKEQWIDWGGPiIWEYYGGTEGQgLTIINGEEwlthPGSV-- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 347 ntqGRPLseEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQhNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIK 426
Cdd:cd05929 300 ---GRAV--LGKVHILDEDGNEVPPGEIGEVYFANGPGFEYTNDPEK-TAAARNEGGWSTLGDVGYLDEDGYLYLTDRRS 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 427 EQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL---PKSINQPDPAQ-MQAFLHQKgVQRHKIPDQW 502
Cdd:cd05929 374 DMIISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHAVVqpaPGADAGTALAEeLIAFLRDR-LSRYKCPRSI 452
|
490 500
....*....|....*....|
gi 2740590833 503 LFVAYWPLTAVGKINKRQLV 522
Cdd:cd05929 453 EFVAELPRDDTGKLYRRLLR 472
|
|
| PRK06178 |
PRK06178 |
acyl-CoA synthetase; Validated |
14-528 |
3.06e-41 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 160.59 E-value: 3.06e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 14 TPNYLWNGKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALF 93
Cdd:PRK06178 25 EPEYPHGERPLTEYLRAWARERPQRPAIIFYGHVITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGIL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 94 RLGAHPVLLMPTQRAHD-VHALCQiARPVAYIIPDCIHgfdyrEMAREVAASCPeLEHIIVDGEAeEFIP---------- 162
Cdd:PRK06178 105 KLGAVHVPVSPLFREHElSYELND-AGAEVLLALDQLA-----PVVEQVRAETS-LRHVIVTSLA-DVLPaeptlplpds 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 163 --------------FASIEDEPLNI--IGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNfvlSARLCAI----NTESV 222
Cdd:PRK06178 177 lraprlaaagaidlLPALRACTAPVplPPPALDALAALNYTGGTTGMPKGCEHTQRDMVYT---AAAAYAVavvgGEDSV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 223 YLAVLPV----AHNFilgspGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLA-LVPALARLWEQARdWEQSDLSSL 297
Cdd:PRK06178 254 FLSFLPEfwiaGENF-----GLLFPLFSGATLVLLARWDAVAFMAAVERYRVTRTVmLVDNAVELMDHPR-FAEYDLSSL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 298 RclQVGGG----RLTPELAEQVMARLGPL--QQVFGTAEGLLCYT----RLDDPYEviINTQ----GRPL-SEEDEINLA 362
Cdd:PRK06178 328 R--QVRVVsfvkKLNPDYRQRWRALTGSVlaEAAWGMTETHTCDTftagFQDDDFD--LLSQpvfvGLPVpGTEFKICDF 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 363 DTNlQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFtTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVE 442
Cdd:PRK06178 404 ETG-ELLPLGAEGEIVVRTPSLLKGYWNKPEATAEAL-RDGWLHTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPSEVE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 443 TLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLhQKGVQRHKIPdQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK06178 482 ALLGQHPAVLGSAVVGRPDPDKGQVPVAFVqLKPGADLTAAALQAWC-RENMAVYKVP-EIRIVDALPMTATGKVRKQDL 559
|
....*..
gi 2740590833 522 VQMAQAE 528
Cdd:PRK06178 560 QALAEEL 566
|
|
| FACL_like_6 |
cd05922 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
59-522 |
5.26e-41 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 157.60 E-value: 5.26e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 59 RLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHP----VLLMPTQRAHDVHALCQIARPvAYIIPDciHGFDY 134
Cdd:cd05922 5 AAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGGRLglvfVPLNPTLKESVLRYLVADAGG-RIVLAD--AGAAD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 135 REMAREVAASCPELehiIVDGE----AEEFIPFASIEDEplniigpgygDIAVLLLSGGTTGTPKLIPRTHdaytYNFVL 210
Cdd:cd05922 82 RLRDALPASPDPGT---VLDADgiraARASAPAHEVSHE----------DLALLLYTSGSTGSPKLVRLSH----QNLLA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 211 SARLCA----INTESVYLAVLPVAHNFilGSPGILGTLSQGGCVLLSDTASCDEAM-PLIEEHKVTHLALVPALarlWEQ 285
Cdd:cd05922 145 NARSIAeylgITADDRALTVLPLSYDY--GLSVLNTHLLRGATLVLTNDGVLDDAFwEDLREHGATGLAGVPST---YAM 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 286 AR--DWEQSDLSSLRCLQVGGGRLTPELAEQvMARLGPLQQV---FGTAEGLLCYTRLddPYEVIIN---TQGRPLSEeD 357
Cdd:cd05922 220 LTrlGFDPAKLPSLRYLTQAGGRLPQETIAR-LRELLPGAQVyvmYGQTEATRRMTYL--PPERILEkpgSIGLAIPG-G 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 358 EINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKIS 437
Cdd:cd05922 296 EFEILDDDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYRRKEGRGGGVLHTGDLARRDEDGFLFIVGRRDRMIKLFGNRIS 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 438 TLEVETLLLQHPDIDDTVVIAVPDElLGERICACL---PKSINQPDPAQMQAFLHqkgvqRHKIPDQWLFVAYWPLTAVG 514
Cdd:cd05922 376 PTEIEAAARSIGLIIEAAAVGLPDP-LGEKLALFVtapDKIDPKDVLRSLAERLP-----PYKVPATVRVVDELPLTASG 449
|
....*...
gi 2740590833 515 KINKRQLV 522
Cdd:cd05922 450 KVDYAALR 457
|
|
| A_NRPS_PvdJ-like |
cd17649 |
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ... |
38-521 |
8.51e-41 |
|
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 156.76 E-value: 8.51e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 38 KTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQrahdvhalcqi 117
Cdd:cd17649 3 AVALVFGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEY----------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 arPVAyiipdcihgfdyremarevaascpELEHIIVDGEAeefipfasiedePLnIIGPGYGDIAVLLLSGGTTGTPKLI 197
Cdd:cd17649 72 --PAE------------------------RLRYMLEDSGA------------GL-LLTHHPRQLAYVIYTSGSTGTPKGV 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 198 PRTHDAYTYNFVLSARLCAINTESVYLAVLPVahNFILGSPGILGTLSQGGCVLLSDT---ASCDEAMPLIEEHKVTHLA 274
Cdd:cd17649 113 AVSHGPLAAHCQATAERYGLTPGDRELQFASF--NFDGAHEQLLPPLICGACVVLRPDelwASADELAEMVRELGVTVLD 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 275 LVPALARLW-EQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEGLL------CYTRLDDPYEVI-I 346
Cdd:cd17649 191 LPPAYLQQLaEEADRTGDGRPPSLRLYIFGGEALSPELLRRWLKAPVRLFNAYGPTEATVtplvwkCEAGAARAGASMpI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 347 ntqGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYyraeqHNTVAFTTDGF------------YRTGDLVRIR 414
Cdd:cd17649 271 ---GRPLGGR-SAYILDADLNPVPVGVTGELYIGGEGLARGY-----LGRPELTAERFvpdpfgapgsrlYRTGDLARWR 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 415 PDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDElLGERICACL--PKSINQP-DPAQMQAFLHQK 491
Cdd:cd17649 342 DDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVALDGA-GGKQLVAYVvlRAAAAQPeLRAQLRTALRAS 420
|
490 500 510
....*....|....*....|....*....|
gi 2740590833 492 gVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17649 421 -LPDYMVPAHLVFLARLPLTPNGKLDRKAL 449
|
|
| PRK05605 |
PRK05605 |
long-chain-fatty-acid--CoA ligase; Validated |
36-520 |
1.19e-40 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 158.62 E-value: 1.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALC 115
Cdd:PRK05605 46 GDRPALDFFGATTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCPQHIVAFYAVLRLGAVVVEHNPLYTAHELEHPF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 QIARPVAYIIPDCIHGfdyreMAREVAASCPeLEHII-VD----------------------------GEAEEFIPFASI 166
Cdd:PRK05605 126 EDHGARVAIVWDKVAP-----TVERLRRTTP-LETIVsVNmiaampllqrlalrlpipalrkaraaltGPAPGTVPWETL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 167 EDEPlnIIGPGYG---------DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLS-ARLCAI-NTESVYLAVLPVAHNFIL 235
Cdd:PRK05605 200 VDAA--IGGDGSDvshprptpdDVALILYTSGTTGKPKGAQLTHRNLFANAAQGkAWVPGLgDGPERVLAALPMFHAYGL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 236 GSPGILGtLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPAL-ARLWEQARDwEQSDLSSLRCLQVGGGRLTPELAEQ 314
Cdd:PRK05605 278 TLCLTLA-VSIGGELVLLPAPDIDLILDAMKKHPPTWLPGVPPLyEKIAEAAEE-RGVDLSGVRNAFSGAMALPVSTVEL 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 315 VMARLGplqqvfgtaeGLLC--YTrLDDPYEVIIntqGRPLSEE------------DEINLAD-TNL-QPVAPSEVGELI 378
Cdd:PRK05605 356 WEKLTG----------GLLVegYG-LTETSPIIV---GNPMSDDrrpgyvgvpfpdTEVRIVDpEDPdETMPDGEEGELL 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 379 TRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIA 458
Cdd:PRK05605 422 VRGPQVFKGYWNRPEETAKSFL-DGWFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPAEVEEVLREHPGVEDAAVVG 500
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740590833 459 VPDELLGERICACLpksINQP----DPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQ 520
Cdd:PRK05605 501 LPREDGSEEVVAAV---VLEPgaalDPEGLRAYC-REHLTRYKVPRRFYHVDELPRDQLGKVRRRE 562
|
|
| PRK13574 |
PRK13574 |
anthranilate synthase component I; Provisional |
716-972 |
1.34e-40 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184155 [Multi-domain] Cd Length: 420 Bit Score: 155.36 E-value: 1.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 716 TAKNYQDNVANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGRQANTPARSFFLRDGDFSAYGFSPETVVEAEGsGW 795
Cdd:PRK13574 156 NKNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLKFDERYLIGSSPELLFRVQD-NI 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 796 INTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHLASRVKGL 875
Cdd:PRK13574 235 VETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPELMYVEKYSHVQHIVSKVIGT 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 876 LHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAGAGL 955
Cdd:PRK13574 315 LKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKDLLRIQAGAGI 394
|
250
....*....|....*..
gi 2740590833 956 VRNSRPEREWQETCEKL 972
Cdd:PRK13574 395 VYDSNPESEYFETEHKL 411
|
|
| A_NRPS_Sfm_like |
cd12115 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ... |
38-521 |
1.75e-40 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.
Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 155.55 E-value: 1.75e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 38 KTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPtqrahdvhalcqi 117
Cdd:cd12115 15 AIALVCGDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDP------------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 ARPVAYIipdcihgfdyREMAREVAAscpelEHIIVDGEaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKLI 197
Cdd:cd12115 82 AYPPERL----------RFILEDAQA-----RLVLTDPD-----------------------DLAYVIYTSGSTGRPKGV 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 198 PRTHDAyTYNFV-LSARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEhkVTHLALV 276
Cdd:cd12115 124 AIEHRN-AAAFLqWAAAAFSAEELAGVLASTSIC--FDLSVFELFGPLATGGKVVLADNVLALPDLPAAAE--VTLINTV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 277 PALARLWEQARDWEQSdlssLRCLQVGGGRLTPELAEQVMARLgPLQQVF---GTAEGLLCYT----RLDDPYEVIIntq 349
Cdd:cd12115 199 PSAAAELLRHDALPAS----VRVVNLAGEPLPRDLVQRLYARL-QVERVVnlyGPSEDTTYSTvapvPPGASGEVSI--- 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 350 GRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYY-RAEQhnTVA-FTTDGF------YRTGDLVRIRPDGNLLV 421
Cdd:cd12115 271 GRPLANT-QAYVLDRALQPVPLGVPGELYIGGAGVARGYLgRPGL--TAErFLPDPFgpgarlYRTGDLVRWRPDGLLEF 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 422 EGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQRHKIPD 500
Cdd:cd12115 348 LGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAIGDAAGERRLVAYIvAEPGAAGLVEDLRRHLGTR-LPAYMVPS 426
|
490 500
....*....|....*....|.
gi 2740590833 501 QWLFVAYWPLTAVGKINKRQL 521
Cdd:cd12115 427 RFVRLDALPLTPNGKIDRSAL 447
|
|
| ttLC_FACS_AEE21_like |
cd12118 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ... |
28-518 |
3.60e-40 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.
Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 155.53 E-value: 3.60e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 28 LAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvLLMPTQR 107
Cdd:cd12118 10 LERAAAVYPDRTSIVYGDRRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGA---VLNALNT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 108 AHDvhalcqiARPVAYIIPdciHGfdyremarevaascpELEHIIVDGE--AEEFIpfASIEDEPLNIIGPGYGDIAVLL 185
Cdd:cd12118 87 RLD-------AEEIAFILR---HS---------------EAKVLFVDREfeYEDLL--AEGDPDFEWIPPADEWDPIALN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAH----NFILGSPGILGTLsqggcVLLsDTASCDEA 261
Cdd:cd12118 140 YTSGTTGRPKGVVYHHRGAYLNALANILEWEMKQHPVYLWTLPMFHcngwCFPWTVAAVGGTN-----VCL-RKVDAKAI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 262 MPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQvMARLG-PLQQVFGTAE----GLLCY- 335
Cdd:cd12118 214 YDLIEKHKVTHFCGAPTVLNMLANAPPSDARPLPHRVHVMTAGAPPPAAVLAK-MEELGfDVTHVYGLTEtygpATVCAw 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 336 ----TRLDDPYEVIINT-QGRPLSEEDEINLADTN-LQPVAP--SEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRT 407
Cdd:cd12118 293 kpewDELPTEERARLKArQGVRYVGLEEVDVLDPEtMKPVPRdgKTIGEIVFRGNIVMKGYLKNPEATAEAFR-GGWFHS 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 408 GDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLP-KSINQPDPAQMQA 486
Cdd:cd12118 372 GDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEAAVVARPDEKWGEVPCAFVElKEGAKVTEEEIIA 451
|
490 500 510
....*....|....*....|....*....|..
gi 2740590833 487 FLHQKgVQRHKIPDQWLFVAYwPLTAVGKINK 518
Cdd:cd12118 452 FCREH-LAGFMVPKTVVFGEL-PKTSTGKIQK 481
|
|
| MenF |
COG1169 |
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ... |
720-972 |
1.01e-39 |
|
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440783 [Multi-domain] Cd Length: 353 Bit Score: 151.07 E-value: 1.01e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 720 YQDNVANAVKDIASGHYQKVILSRQVEL--GSNIDITHSywLGR--QANTPARSFFLRDGDFSAY-GFSPETVVEAEGsG 794
Cdd:COG1169 91 WREAVAQALEAIRAGELDKVVLARALDLtlDEPIDPRAL--LARlrRRNPDCYTFAVELGAGDGFvGASPERLVRRRG-G 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 795 WINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQpeTLCVSEFMAICERGSVQHLASRVKG 874
Cdd:COG1169 168 QLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREALAPLCS--SLDVPEEPELLRLRNVQHLATPITG 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 875 LLHTDKNRWDAFIALFP--AVtaSGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAG 952
Cdd:COG1169 246 TLDPGVSALDLAAALHPtpAV--GGTPREAALALIRELEPFDRGWYAGPVGWVDADGDGEFAVAIRSALIDGNRARLFAG 323
|
250 260
....*....|....*....|
gi 2740590833 953 AGLVRNSRPEREWQETCEKL 972
Cdd:COG1169 324 AGIVAGSDPEAEWAETEAKL 343
|
|
| PRK06155 |
PRK06155 |
crotonobetaine/carnitine-CoA ligase; Provisional |
21-530 |
4.44e-39 |
|
crotonobetaine/carnitine-CoA ligase; Provisional
Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 153.38 E-value: 4.44e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 21 GKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPV 100
Cdd:PRK06155 20 ERTLPAMLARQAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGNRIEFLDVFLGCAWLGAIAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 101 LLMPTQRAHDVHALCQIARPVAYIIPDcihgfDYREMAREVAASCPELEHI-IVDGEAEEFIP--FASIE----DEPLNI 173
Cdd:PRK06155 100 PINTALRGPQLEHILRNSGARLLVVEA-----ALLAALEAADPGDLPLPAVwLLDAPASVSVPagWSTAPlpplDAPAPA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 174 IGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNfilgspGILGTLSQ----GGC 249
Cdd:PRK06155 175 AAVQPGDTAAILYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGADDVLYTTLPLFHT------NALNAFFQallaGAT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 250 VLLSDTASCDEAMPLIEEHK--VTHL--ALVPALARLWEQARDWEQSdlsslrcLQVG-GGRLTPELAEQVMARLG-PLQ 323
Cdd:PRK06155 249 YVLEPRFSASGFWPAVRRHGatVTYLlgAMVSILLSQPARESDRAHR-------VRVAlGPGVPAALHAAFRERFGvDLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 324 QVFGTAE-GLLCYTRLDDPYEviiNTQGRpLSEEDEINLADTNLQPVAPSEVGELITRG--PYTI-TGYYR-AEQhnTVA 398
Cdd:PRK06155 322 DGYGSTEtNFVIAVTHGSQRP---GSMGR-LAPGFEARVVDEHDQELPDGEPGELLLRAdePFAFaTGYFGmPEK--TVE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 399 FTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLG-ERICACLPKSIN 477
Cdd:PRK06155 396 AWRNLWFHTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSHPAVAAAAVFPVPSELGEdEVMAAVVLRDGT 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 2740590833 478 QPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENT 530
Cdd:PRK06155 476 ALEPVALVRHCEPR-LAYFAVPRYVEFVAALPKTENGKVQKFVLREQGVTADT 527
|
|
| PRK13572 |
PRK13572 |
anthranilate synthase component I; Provisional |
689-977 |
7.54e-39 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 237432 [Multi-domain] Cd Length: 435 Bit Score: 150.66 E-value: 7.54e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 689 EKVKRADqlgtpaFPQTKE-VEIINTADTAKNYQDNVANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGRQANtPA 767
Cdd:PRK13572 149 EKAKRFE------IEEEDGgSEVLGCDADREEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNLREIN-PS 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 768 RSFFLRDGDFSAYGFSPETVVEAEGSGW-INtqPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPIC 846
Cdd:PRK13572 222 PYMFLLEFDKDVVGASPETMASVENNILkIN--PIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVS 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 847 QPETLCVSEFMAICERGSVQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLD 926
Cdd:PRK13572 300 KSGSVRLERFFDVVKYSHVQHIESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVGYFS 379
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2740590833 927 STGKLDAALVLRsLYQHKERCWLQAGAGLVRNSRPEREWQETCEKLECIMK 977
Cdd:PRK13572 380 NSGNADLAIAIR-MAEIDKVCRVRAGAGIVADSVPEKEFYETERKMAAVLK 429
|
|
| MACS_AAE_MA_like |
cd05970 |
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ... |
31-518 |
3.95e-38 |
|
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.
Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 150.72 E-value: 3.95e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 31 WSSIWGNKTALIY-----HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPT 105
Cdd:cd05970 26 MAKEYPDKLALVWcddagEERIFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSLLALHKLGAIAIPATHQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 106 QRAHDVHALCQIARpVAYIIpdCIHGFDYREMAREVAASCPELEHIIV--DGEAEEFIPFASIEDEPLNIIGPGYG---- 179
Cdd:cd05970 106 LTAKDIVYRIESAD-IKMIV--AIAEDNIPEEIEKAAPECPSKPKLVWvgDPVPEGWIDFRKLIKNASPDFERPTAnsyp 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 ---DIAVLLLSGGTTGTPKLIprTHDaYTYNfvlsarLCAINTESVYLAVLPVAHNFILGSPG--------ILGTLSQGG 248
Cdd:cd05970 183 cgeDILLVYFSSGTTGMPKMV--EHD-FTYP------LGHIVTAKYWQNVREGGLHLTVADTGwgkavwgkIYGQWIAGA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 249 CVLLSDTASCDEAMPL--IEEHKVTHLALVPALARLWEQArDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQV 325
Cdd:cd05970 254 AVFVYDYDKFDPKALLekLSKYGVTTFCAPPTIYRFLIRE-DLSRYDLSSLRYCTTAGEALNPEVFNTFKEKTGiKLMEG 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 326 FGTAEGLLCYTRLddPY-EVIINTQGRPlSEEDEINLADTNLQPVAPSEVGELITR----GPYTI-TGYYRAEQHNTVAF 399
Cdd:cd05970 333 FGQTETTLTIATF--PWmEPKPGSMGKP-APGYEIDLIDREGRSCEAGEEGEIVIRtskgKPVGLfGGYYKDAEKTAEVW 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 400 TtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSIN 477
Cdd:cd05970 410 H-DGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQHPAVLECAVTGVPDPIRGQVVKAtiVLAKGYE 488
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2740590833 478 QPDPAQMQAFLHQKGVQR-HKIPDQWLFVAYWPLTAVGKINK 518
Cdd:cd05970 489 PSEELKKELQDHVKKVTApYKYPRIVEFVDELPKTISGKIRR 530
|
|
| VL_LC_FACS_like |
cd05907 |
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ... |
48-492 |
5.73e-38 |
|
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 148.51 E-value: 5.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTqrahdvhalcqiarpvayiipd 127
Cdd:cd05907 6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPT---------------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 cihgfdyremarevaASCPELEHIIVDGEAEEfipfasiedeplnIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYN 207
Cdd:cd05907 64 ---------------SSAEQIAYILNDSEAKA-------------LFVEDPDDLATIIYTSGTTGRPKGVMLSHRNILSN 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 208 FVLSARLCAINTESVYLAVLPVAHNF--ILGspgILGTLSQGGCVLLsdtASCDEA-MPLIEEHKVTHLALVPalaRLWE 284
Cdd:cd05907 116 ALALAERLPATEGDRHLSFLPLAHVFerRAG---LYVPLLAGARIYF---ASSAETlLDDLSEVRPTVFLAVP---RVWE 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 285 QARDWEQSDLSS--------------LRCLQVGGGRLTPELAEQvMARLG-PLQQVFGTAE--GLLCYTRLDDPYeviIN 347
Cdd:cd05907 187 KVYAAIKVKAVPglkrklfdlavggrLRFAASGGAPLPAELLHF-FRALGiPVYEGYGLTEtsAVVTLNPPGDNR---IG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 348 TQGRPLSEEdEINLADTnlqpvapsevGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKE 427
Cdd:cd05907 263 TVGKPLPGV-EVRIADD----------GEILVRGPNVMLGYYKNPEATAEALDADGWLHTGDLGEIDEDGFLHITGRKKD 331
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740590833 428 -QINRSGEKISTLEVETLLLQHPDIDDTVVIAvpDellGERICACLpksInQPDPAQMQAFLHQKG 492
Cdd:cd05907 332 lIITSGGKNISPEPIENALKASPLISQAVVIG--D---GRPFLVAL---I-VPDPEALEAWAEEHG 388
|
|
| AAS_C |
cd05909 |
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ... |
48-525 |
6.86e-38 |
|
C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.
Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 149.02 E-value: 6.86e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLyHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARpVAYIIP- 126
Cdd:cd05909 8 LTYRKLLTGAIALARKL-AKMTKEGENVGVMLPPSAGGALANFALALSGKVPVMLNYTAGLRELRACIKLAG-IKTVLTs 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 -------DCIHGFDYREMAR-----EVAASCPELEHIIVdGEAEEFIPFASIEDEPLNIIGPGygDIAVLLLSGGTTGTP 194
Cdd:cd05909 86 kqfieklKLHHLFDVEYDARivyleDLRAKISKADKCKA-FLAGKFPPKWLLRIFGVAPVQPD--DPAVILFTSGSEGLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 195 KLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLA 274
Cdd:cd05909 163 KGVVLSHKNLLANVEQITAIFDPNPEDVVFGALPFFHSFGLTGCLWLPLLSGIKVVFHPNPLDYKKIPELIYDKKATILL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 275 LVPALARLWeqARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRLDDPYEVIINTQGRPL 353
Cdd:cd05909 243 GTPTFLRGY--ARAAHPEDFSSLRLVVAGAEKLKDTLRQEFQEKFGiRILEGYGTTECSPVISVNTPQSPNKEGTVGRPL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 354 --------SEEDEInladtnlqPVAPSEVGELITRGPYTITGYYRAEQHnTVAFTTDGFYRTGDLVRIRPDGNLLVEGRI 425
Cdd:cd05909 321 pgmevkivSVETHE--------EVPIGEGGLLLVRGPNVMLGYLNEPEL-TSFAFGDGWYDTGDIGKIDGEGFLTITGRL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 426 KEQINRSGEKISTLEVETLLLQHPDIDDTV-VIAVPDELLGERICACLpkSINQPDPAQMQAFLHQKGVQRHKIPDQWLF 504
Cdd:cd05909 392 SRFAKIAGEMVSLEAIEDILSEILPEDNEVaVVSVPDGRKGEKIVLLT--TTTDTDPSSLNDILKNAGISNLAKPSYIHQ 469
|
490 500
....*....|....*....|.
gi 2740590833 505 VAYWPLTAVGKINKRQLVQMA 525
Cdd:cd05909 470 VEEIPLLGTGKPDYVTLKALA 490
|
|
| ABCL |
cd05958 |
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ... |
38-521 |
8.50e-38 |
|
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.
Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 147.62 E-value: 8.50e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 38 KTALIYHEQRLTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVhalcq 116
Cdd:cd05958 1 RTCLRSPEREWTYRDLLALANRIANVLVGElGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKEL----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 iarpvAYIIPDCihgfdyremaREVAASCPELEhiivdgeaeefipfaSIEDeplniigpgygDIAVLLLSGGTTGTPKL 196
Cdd:cd05958 76 -----AYILDKA----------RITVALCAHAL---------------TASD-----------DICILAFTSGTTGAPKA 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAYtynfVLSARLCAINT-----ESVYLAVLPVAHNFILGSpGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVT 271
Cdd:cd05958 115 TMHFHRDP----LASADRYAVNVlrlreDDRFVGSPPLAFTFGLGG-VLLFPFGVGASGVLLEEATPDLLLSAIARYKPT 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRlDDPYEVIINTQG 350
Cdd:cd05958 190 VLFTAPTAYRAMLAHPDAAGPDLSSLRKCVSAGEALPAALHRAWKEATGiPIIDGIGSTEMFHIFIS-ARPGDARPGATG 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 351 RPLsEEDEINLADTNLQPVAPSEVGELITRGPytiTGY-YRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQI 429
Cdd:cd05958 269 KPV-PGYEAKVVDDEGNPVPDGTIGRLAVRGP---TGCrYLADKRQRTYVQ-GGWNITGDTYSRDPDGYFRHQGRSDDMI 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 430 NRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL---PKSINQPDPA-QMQAFLHQKgVQRHKIPDQWLFV 505
Cdd:cd05958 344 VSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVvlrPGVIPGPVLArELQDHAKAH-IAPYKYPRAIEFV 422
|
490
....*....|....*.
gi 2740590833 506 AYWPLTAVGKINKRQL 521
Cdd:cd05958 423 TELPRTATGKLQRFAL 438
|
|
| PRK08276 |
PRK08276 |
long-chain-fatty-acid--CoA ligase; Validated |
46-521 |
8.99e-38 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 148.90 E-value: 8.99e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHpvllmptqrahdvhaLCQI-----ARP 120
Cdd:PRK08276 10 EVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLY---------------YTPInwhltAAE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 121 VAYIIPDC-----IHGFDYREMAREVAASCPE-LEH-IIVDGEAEEFIPFAS---------IEDEPlniigPGygdiAVL 184
Cdd:PRK08276 75 IAYIVDDSgakvlIVSAALADTAAELAAELPAgVPLlLVVAGPVPGFRSYEEalaaqpdtpIADET-----AG----ADM 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 185 LLSGGTTGTPKLI--PRTH-DAYTYNFVLSARLCA---INTESVYLAVLPVAHnfilGSPGILGTLSQ--GGCVLLSDTA 256
Cdd:PRK08276 146 LYSSGTTGRPKGIkrPLPGlDPDEAPGMMLALLGFgmyGGPDSVYLSPAPLYH----TAPLRFGMSALalGGTVVVMEKF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 257 SCDEAMPLIEEHKVTHLALVPA----LARLWEQARdwEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEG 331
Cdd:PRK08276 222 DAEEALALIERYRVTHSQLVPTmfvrMLKLPEEVR--ARYDVSSLRVAIHAAAPCPVEVKRAMIDWWGPiIHEYYASSEG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 332 -----LLCYTRLDDPYEViintqGRPLseEDEINLADTNLQPVAPSEVGEL-ITRGPYTITgYYRAEQHNTVAFTTDGFY 405
Cdd:PRK08276 300 ggvtvITSEDWLAHPGSV-----GKAV--LGEVRILDEDGNELPPGEIGTVyFEMDGYPFE-YHNDPEKTAAARNPHGWV 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 406 RTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPA-- 482
Cdd:PRK08276 372 TVGDVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVqPADGADAGDAla 451
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 2740590833 483 -QMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK08276 452 aELIAWLRGR-LAHYKCPRSIDFEDELPRTPTGKLYKRRL 490
|
|
| PLN02860 |
PLN02860 |
o-succinylbenzoate-CoA ligase |
26-525 |
9.70e-38 |
|
o-succinylbenzoate-CoA ligase
Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 149.95 E-value: 9.70e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 26 QQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPT 105
Cdd:PLN02860 11 QCLTRLATLRGNAVVTISGNRRRTGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 106 QRAHDVHALCQIARPVAYIIPD-CIHGFDYREMARevaasCPELE-HIIVDGEAEEFIPFASIEDEPLNIIGPGYG---- 179
Cdd:PLN02860 91 WSFEEAKSAMLLVRPVMLVTDEtCSSWYEELQNDR-----LPSLMwQVFLESPSSSVFIFLNSFLTTEMLKQRALGttel 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 -------DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHnfILGSPGILGTLSQGGC-VL 251
Cdd:PLN02860 166 dyawapdDAVLICFTSGTTGRPKGVTISHSALIVQSLAKIAIVGYGEDDVYLHTAPLCH--IGGLSSALAMLMVGAChVL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 252 LS--DTASCDEAmplIEEHKVTHLALVPA-LARLWEQARDWEQSDL-SSLRCLQVGGGRLTPELAEQVmARLGPLQQVFg 327
Cdd:PLN02860 244 LPkfDAKAALQA---IKQHNVTSMITVPAmMADLISLTRKSMTWKVfPSVRKILNGGGSLSSRLLPDA-KKLFPNAKLF- 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 328 TAEGL------LCYTRLDDPyevIINTQGRPLSEEDEINLADTNL-----------------QPVAPSEVGELITRGPYT 384
Cdd:PLN02860 319 SAYGMteacssLTFMTLHDP---TLESPKQTLQTVNQTKSSSVHQpqgvcvgkpaphvelkiGLDESSRVGRILTRGPHV 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 385 ITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELL 464
Cdd:PLN02860 396 MLGYWGQNSETASVLSNDGWLDTGDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPGVASVVVVGVPDSRL 475
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2740590833 465 GERICACLP-----KSINQPDPAQMQAFL----------HQKGVQRHKIPDqwLFVAY---WPLTAVGKINKRQLVQMA 525
Cdd:PLN02860 476 TEMVVACVRlrdgwIWSDNEKENAKKNLTlssetlrhhcREKNLSRFKIPK--LFVQWrkpFPLTTTGKIRRDEVRREV 552
|
|
| A_NRPS_CmdD_like |
cd17652 |
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ... |
39-521 |
1.09e-37 |
|
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).
Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 147.01 E-value: 1.09e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIA 118
Cdd:cd17652 4 PAVVFGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYMLADA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 119 RPVAyiipdcihgfdyremarevaascpelehIIVDGEAEEFIPFASiedeplniigpgygdiavlllsgGTTGTPKLIP 198
Cdd:cd17652 84 RPAL----------------------------LLTTPDNLAYVIYTS-----------------------GSTGRPKGVV 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 199 RTHdaytynfvlsARLCAINTESV-YLAVLPVAHNFILGSPG-------ILGTLSQGGCVLLSDTASCDEAMPLIE---E 267
Cdd:cd17652 113 VTH----------RGLANLAAAQIaAFDVGPGSRVLQFASPSfdasvweLLMALLAGATLVLAPAEELLPGEPLADllrE 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 268 HKVTHLALVP-ALARLweqardwEQSDLSSLRCLQVGGGRLTPELAEqvmaRLGPLQQVF---GTAEGLLCYTR---LDD 340
Cdd:cd17652 183 HRITHVTLPPaALAAL-------PPDDLPDLRTLVVAGEACPAELVD----RWAPGRRMInayGPTETTVCATMagpLPG 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 PYEVIIntqGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF-------YRTGDLVRI 413
Cdd:cd17652 252 GGVPPI---GRPVPGT-RVYVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAERFVADPFgapgsrmYRTGDLARW 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA-CLPKSINQPDPAQMQAFLHQKg 492
Cdd:cd17652 328 RADGQLEFLGRADDQVKIRGFRIELGEVEAALTEHPGVAEAVVVVRDDRPGDKRLVAyVVPAPGAAPTAAELRAHLAER- 406
|
490 500
....*....|....*....|....*....
gi 2740590833 493 VQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17652 407 LPGYMVPAAFVVLDALPLTPNGKLDRRAL 435
|
|
| FACL_like_4 |
cd05944 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
179-525 |
1.95e-37 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 144.55 E-value: 1.95e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 179 GDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFilGSPGILGT-LSQGGCVLLS---- 253
Cdd:cd05944 2 DDVAAYFHTGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDDVLLCGLPLFHVN--GSVVTLLTpLASGAHVVLAgpag 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 254 --DTASCDEAMPLIEEHKVTHLALVP-ALARLWEQARDweqSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTA 329
Cdd:cd05944 80 yrNPGLFDNFWKLVERYRITSLSTVPtVYAALLQVPVN---ADISSLRFAMSGAAPLPVELRARFEDATGlPVVEGYGLT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 330 EGLlCYTRLDDPY-EVIINTQGRPLSEED----EINLADTNLQPVAPSEVGELITRGPYTITGYYRAEqHNTVAFTTDGF 404
Cdd:cd05944 157 EAT-CLVAVNPPDgPKRPGSVGLRLPYARvrikVLDGVGRLLRDCAPDEVGEICVAGPGVFGGYLYTE-GNKNAFVADGW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 405 YRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLP-KSINQPDPAQ 483
Cdd:cd05944 235 LNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELPVAYVQlKPGAVVEEEE 314
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2740590833 484 MQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMA 525
Cdd:cd05944 315 LLAWARDHVPERAAVPKHIEVLEELPVTAVGKVFKPALRADA 356
|
|
| ACS-like |
cd17634 |
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ... |
36-516 |
1.44e-36 |
|
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 146.57 E-value: 1.44e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIY------HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAH 109
Cdd:cd17634 67 GDRTAIIYegddtsQSRTISYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFGGFAPE 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 110 DVHALCQIARPVAYIIPDcihGF-------DYREMAREVA-ASCPELEHIIV--------------DGEAEEFIPFASIE 167
Cdd:cd17634 147 AVAGRIIDSSSRLLITAD---GGvragrsvPLKKNVDDALnPNVTSVEHVIVlkrtgsdidwqegrDLWWRDLIAKASPE 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 168 DEPLNIIGPgygDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLC-AINTESVYLAVLPVAhnFILGSPGIL-GTLS 245
Cdd:cd17634 224 HQPEAMNAE---DPLFILYTSGTTGKPKGVLHTTGGYLVYAATTMKYVfDYGPGDIYWCTADVG--WVTGHSYLLyGPLA 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 246 QGGCVLLSDTA----SCDEAMPLIEEHKVTHLALVPALAR-LWEQARDW-EQSDLSSLRCLQVGGGRLTPELAEQVMARL 319
Cdd:cd17634 299 CGATTLLYEGVpnwpTPARMWQVVDKHGVNILYTAPTAIRaLMAAGDDAiEGTDRSSLRILGSVGEPINPEAYEWYWKKI 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 320 GP-----LQQVFGTAEGLLCYTRLDDPYEVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPY---TITGYYRA 391
Cdd:cd17634 379 GKekcpvVDTWWQTETGGFMITPLPGAIELKAGSATRPVFGV-QPAVVDNEGHPQPGGTEGNLVITDPWpgqTRTLFGDH 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 392 EQHNTVAFTT-DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA 470
Cdd:cd17634 458 ERFEQTYFSTfKGMYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIESVLVAHPKVAEAAVVGIPHAIKGQAPYA 537
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 2740590833 471 CLPKSINQPDPAQMQAFLHQ---KGVQRHKIPDQWLFVAYWPLTAVGKI 516
Cdd:cd17634 538 YVVLNHGVEPSPELYAELRNwvrKEIGPLATPDVVHWVDSLPKTRSGKI 586
|
|
| PRK05940 |
PRK05940 |
anthranilate synthase component I; |
783-971 |
1.48e-36 |
|
anthranilate synthase component I;
Pssm-ID: 235651 [Multi-domain] Cd Length: 463 Bit Score: 144.49 E-value: 1.48e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 783 SPETVVEAEGsGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAIcER 862
Cdd:PRK05940 255 SPERLVQLQG-NQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWGSVEVDELLTI-ER 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 863 GS-VQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSL- 940
Cdd:PRK05940 333 YShVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRGNLDLNILIRTLl 412
|
170 180 190
....*....|....*....|....*....|....*
gi 2740590833 941 ----YQHKERCWLQAGAGLVRNSRPEREWQETCEK 971
Cdd:PRK05940 413 ytplSRGLSTIWGQVGAGIVADSDPEKEWLESLQK 447
|
|
| PRK07786 |
PRK07786 |
long-chain-fatty-acid--CoA ligase; Validated |
37-537 |
2.37e-36 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 145.31 E-value: 2.37e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPV----LLMPTQrahdvh 112
Cdd:PRK07786 32 DAPALRFLGNTTTWRELDDRVAALAGALSRRGVGFGDRVLILMLNRTEFVESVLAANMLGAIAVpvnfRLTPPE------ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 113 alcqiarpVAYIIPDCIHGFDYRE-----MAREVAASCPELEHIIVDG---------------EAEEFIPFASI-EDEPl 171
Cdd:PRK07786 106 --------IAFLVSDCGAHVVVTEaalapVATAVRDIVPLLSTVVVAGgssddsvlgyedllaEAGPAHAPVDIpNDSP- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 172 niigpgygdiAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTES-VYLAVLPVAHNFILGSpgILGTLSQGGCV 250
Cdd:PRK07786 177 ----------ALIMYTSGTTGRPKGAVLTHANLTGQAMTCLRTNGADINSdVGFVGVPLFHIAGIGS--MLPGLLLGAPT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 LLSDTASCD--EAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSsLRCLQVGGGRLTPELAEQvMARLGPLQQ---V 325
Cdd:PRK07786 245 VIYPLGAFDpgQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLA-LRVLSWGAAPASDTLLRQ-MAATFPEAQilaA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 326 FGTAE--GLLCYTRLDDPYEVIiNTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDG 403
Cdd:PRK07786 323 FGQTEmsPVTCMLLGEDAIRKL-GSVGKVIPTV-AARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFA-GG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 404 FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGEricacLPKSINQPDPA- 482
Cdd:PRK07786 400 WFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEKWGE-----VPVAVAAVRNDd 474
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 483 ------QMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL-VQMAQAENTETAENNS 537
Cdd:PRK07786 475 aaltleDLAEFLTDR-LARYKHPKALEIVDALPRNPAGKVLKTELrERYGACVNVERRSASA 535
|
|
| PLN02574 |
PLN02574 |
4-coumarate--CoA ligase-like |
48-521 |
2.49e-36 |
|
4-coumarate--CoA ligase-like
Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 145.37 E-value: 2.49e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHAL---CQIArpVAY 123
Cdd:PLN02574 67 ISYSELQPLVKSMAAGLYHVmGVRQGDVVLLLLPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIKKRvvdCSVG--LAF 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 124 IIPDCIHGFdyrEMAREVAASCPELEHIivDGEAEEFIPFAS-IEDEPLNIIGP--GYGDIAVLLLSGGTTGTPKLIPRT 200
Cdd:PLN02574 145 TSPENVEKL---SPLGVPVIGVPENYDF--DSKRIEFPKFYElIKEDFDFVPKPviKQDDVAAIMYSSGTTGASKGVVLT 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 201 HDaytyNFVLSARL---------CAINTESVYLAVLPVAHNFILgSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVT 271
Cdd:PLN02574 220 HR----NLIAMVELfvrfeasqyEYPGSDNVYLAALPMFHIYGL-SLFVVGLLSLGSTIVVMRRFDASDMVKVIDRFKVT 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPA-LARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG--PLQQVFGTAEGLLCYTRLddpyeviINT 348
Cdd:PLN02574 295 HFPVVPPiLMALTKKAKGVCGEVLKSLKQVSCGAAPLSGKFIQDFVQTLPhvDFIQGYGMTESTAVGTRG-------FNT 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 349 QgrPLSEEDEINLADTNLQP----------VAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGN 418
Cdd:PLN02574 368 E--KLSKYSSVGLLAPNMQAkvvdwstgclLPPGNCGELWIQGPGVMKGYLNNPKATQSTIDKDGWLRTGDIAYFDEDGY 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 419 LLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKsinQPDPAQMQAFLH---QKGVQR 495
Cdd:PLN02574 446 LYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVR---RQGSTLSQEAVInyvAKQVAP 522
|
490 500
....*....|....*....|....*.
gi 2740590833 496 HKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PLN02574 523 YKKVRKVVFVQSIPKSPAGKILRREL 548
|
|
| PRK06145 |
PRK06145 |
acyl-CoA synthetase; Validated |
23-521 |
4.62e-36 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 143.49 E-value: 4.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 23 TLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpVLL 102
Cdd:PRK06145 3 NLSASIAFHARRTPDRAALVYRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGA--VFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 103 MPTQRahdvhalcqIARP-VAYIIPDCihGFDYREMAREVAAScPELEH--IIVDGEAEEFIPFASIEDEPlniIGPGY- 178
Cdd:PRK06145 81 PINYR---------LAADeVAYILGDA--GAKLLLVDEEFDAI-VALETpkIVIDAAAQADSRRLAQGGLE---IPPQAa 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 179 ---GDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGIlGTLSQGGCVLLSDT 255
Cdd:PRK06145 146 vapTDLVRLMYTSGTTDRPKGVMHSYGNLHWKSIDHVIALGLTASERLLVVGPLYHVGAFDLPGI-AVLWVGGTLRIHRE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 256 ASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLqVGGGRLTPELAEQVMARL---GPLQQVFGTAEGL 332
Cdd:PRK06145 225 FDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWC-IGGGEKTPESRIRDFTRVftrARYIDAYGLTETC 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 333 LCYTRLDDPYEV-IINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLV 411
Cdd:PRK06145 304 SGDTLMEAGREIeKIGSTGRALAHV-EIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAFY-GDWFRSGDVG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 412 RIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPdpaqmqafLHQK 491
Cdd:PRK06145 382 YLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGERITAVVVLNPGAT--------LTLE 453
|
490 500 510
....*....|....*....|....*....|....*...
gi 2740590833 492 GVQRH--------KIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK06145 454 ALDRHcrqrlasfKVPRQLKVRDELPRNPSGKVLKRVL 491
|
|
| ACLS-CaiC |
cd17637 |
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ... |
222-518 |
9.13e-36 |
|
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 138.94 E-value: 9.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 222 VYLAVLPVAHnfILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLA-LVPALARLWEQArDWEQSDLSSLRcl 300
Cdd:cd17637 43 VYLNMLPLFH--IAGLNLALATFHAGGANVVMEKFDPAEALELIEEEKVTLMGsFPPILSNLLDAA-EKSGVDLSSLR-- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 301 QVGGgrL-TPElaeqVMARL-----GPLQQVFGTAE--GLLCYTRLDD-PyeviiNTQGRPLSEEDeINLADTNLQPVAP 371
Cdd:cd17637 118 HVLG--LdAPE----TIQRFeettgATFWSLYGQTEtsGLVTLSPYRErP-----GSAGRPGPLVR-VRIVDDNDRPVPA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 372 SEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRI--KEQINRSGEKISTLEVETLLLQHP 449
Cdd:cd17637 186 GETGEIVVRGPLVFQGYWNLPELTAYTFR-NGWHHTGDLGRFDEDGYLWYAGRKpeKELIKPGGENVYPAEVEKVILEHP 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 450 DIDDTVVIAVPDELLGERI---CACLPKSinQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINK 518
Cdd:cd17637 265 AIAEVCVIGVPDPKWGEGIkavCVLKPGA--TLTADELIEFVGSR-IARYKKPRYVVFVEALPKTADGSIDR 333
|
|
| PRK09070 |
PRK09070 |
aminodeoxychorismate synthase component I; |
698-971 |
1.25e-35 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236371 [Multi-domain] Cd Length: 447 Bit Score: 141.38 E-value: 1.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 698 GTPAFPQTKEVEIINTADTAKnYQDNVANAVKDIASGHYQKVILSR--QVELGSNIDITHSYWLGRQANTPARSFFLRDG 775
Cdd:PRK09070 164 ALPPLPVWLAPQAVEEDPPER-FTDGVERVLDYIRAGDVFQVNLSRawQAQFANAVDPAALYARLRAANPAPFSGLFVAA 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 776 DFSAYGFSPETVVEAEGsGWINTQPLAGTRALTHDKkQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSE 855
Cdd:PRK09070 243 GRAIVSSSPERLVSVQG-GVVQTRPIAGTRPRFAGD-DDAALIRELVGHPKERAEHVMLIDLERNDLGRICAPGSVEVDE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 856 FMAICERGSVQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAAL 935
Cdd:PRK09070 321 LMTVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYLNRDGDMDLNI 400
|
250 260 270
....*....|....*....|....*....|....*.
gi 2740590833 936 VLRSLYQHKERCWLQAGAGLVRNSRPEREWQETCEK 971
Cdd:PRK09070 401 LIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAK 436
|
|
| DltA |
cd05945 |
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ... |
37-521 |
3.00e-35 |
|
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 140.07 E-value: 3.00e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQ 116
Cdd:cd05945 6 DRPAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERIREILD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 IARPVAyiipdcihgfdyremarevaascpelehIIVDGeaeefipfasiedeplniigpgyGDIAVLLLSGGTTGTPKL 196
Cdd:cd05945 86 AAKPAL----------------------------LIADG-----------------------DDNAYIIFTSGSTGRPKG 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAYTyNFV--LSARLcAINTESVYLAVLPvaHNFILGSPGILGTLSQGGC-VLLSDTASCDEAMPL--IEEHKVT 271
Cdd:cd05945 115 VQISHDNLV-SFTnwMLSDF-PLGPGDVFLNQAP--FSFDLSVMDLYPALASGATlVPVPRDATADPKQLFrfLAEHGIT 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLgPLQQVFGT-----AEGLLCYTRLDDpyEVII 346
Cdd:cd05945 191 VWVSTPSFAAMCLLSPTFTPESLPSLRHFLFCGEVLPHKTARALQQRF-PDARIYNTygpteATVAVTYIEVTP--EVLD 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 347 NTQ----GRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYY-RAEQHNTVAFTTDGF--YRTGDLVRIRPDGNL 419
Cdd:cd05945 268 GYDrlpiGYAKPGAK-LVILDEDGRPVPPGEKGELVISGPSVSKGYLnNPEKTAAAFFPDEGQraYRTGDLVRLEADGLL 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 420 LVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSINQPDPAQMQAFLhQKGVQRHK 497
Cdd:cd05945 347 FYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPKYKGEKVTELIAfvVPKPGAEAGLTKAIKAEL-AERLPPYM 425
|
490 500
....*....|....*....|....
gi 2740590833 498 IPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05945 426 IPRRFVYLDELPLNANGKIDRKAL 449
|
|
| PRK06404 |
PRK06404 |
anthranilate synthase component I; Reviewed |
685-976 |
3.95e-35 |
|
anthranilate synthase component I; Reviewed
Pssm-ID: 102361 [Multi-domain] Cd Length: 351 Bit Score: 137.31 E-value: 3.95e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 685 SILNEKVKRAdqlGTPAF----PQTKEVEIIN-----TADTAKNYQD-----NVANAVKDIASGHYQKVILSRQVElgSN 750
Cdd:PRK06404 61 ACFNNKVEKS---GWPYFysmdPETSYKRNIErksfkTVKLKGNYNDislslKIKELIELIRAGEVLQVVISREFE--AN 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 751 IDITHsywLGRQANTPARS---FFLRDGDFSAYGFSPETVVEAEGSGwINTQPLAGTRAlthdkkqDQQLRADLLSDPKE 827
Cdd:PRK06404 136 IDFKE---KLSEFINNDRSryvFYYRFGKYRVVGSSPENVFTVNGNI-INVDPIAGTYD-------DKILSNELLNSEKD 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 828 ISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHLASRVKGLLhTDKNRWDAFIALFPAVTASGIPKKPALHTI 907
Cdd:PRK06404 205 KLEHRMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSVKHLVSQVTAKF-SNASYRDILASMFPAGTVSGSPKERAIEII 283
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2740590833 908 SRYEGEPRRLYSGCVMLLdSTGKLDAALVLRSLYQHKERCWLQAGAGLVRNSRPEREWQETCEKLECIM 976
Cdd:PRK06404 284 NKYEETPRGPYGGAIGII-SKGYTDMALVIRTAYSHGNGFRVRAGAGIVKDSDPEDEVNEIYSKARSVM 351
|
|
| PRK13383 |
PRK13383 |
acyl-CoA synthetase; Provisional |
5-521 |
8.32e-35 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 140.13 E-value: 8.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 5 SIPEKTLTMTPNYLWNGKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRIS 84
Cdd:PRK13383 18 PSPRAVLRLLREASRGGTNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATESLARRLTRDGVAPGRAVGVMCRNGRG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 85 FVVTCFALFRLGAHpVLLMPTQRAHDVHALCQIARPVAYIIPDcihgfdyREMAREVAAScpelehiivdGEAEEFIPFA 164
Cdd:PRK13383 98 FVTAVFAVGLLGAD-VVPISTEFRSDALAAALRAHHISTVVAD-------NEFAERIAGA----------DDAVAVIDPA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 165 SIEDEPLN----IIGPGygdiAVLLLSGGTTGTPKLIPRT---HDAYTYNFVLSARlCAINTESVYLAVLPVAHNFILGS 237
Cdd:PRK13383 160 TAGAEESGgrpaVAAPG----RIVLLTSGTTGKPKGVPRApqlRSAVGVWVTILDR-TRLRTGSRISVAMPMFHGLGLGM 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 238 pgILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVP-ALARLWE---QARdwEQSDLSSLRCLQVGGGRLTPELAE 313
Cdd:PRK13383 235 --LMLTIALGGTVLTHRHFDAEAALAQASLHRADAFTAVPvVLARILElppRVR--ARNPLPQLRVVMSSGDRLDPTLGQ 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 314 QVMARLGP-LQQVFGTAE----GLLCYTRLDDPYEviinTQGRPLSEeDEINLADTNLQPVAPSEVGELITRGPYTITGY 388
Cdd:PRK13383 311 RFMDTYGDiLYNGYGSTEvgigALATPADLRDAPE----TVGKPVAG-CPVRILDRNNRPVGPRVTGRIFVGGELAGTRY 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 389 YRAEQHNTVafttDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERI 468
Cdd:PRK13383 386 TDGGGKAVV----DGMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRL 461
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 2740590833 469 CACLpksINQP----DPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK13383 462 AAFV---VLHPgsgvDAAQLRDYLKDR-VSRFEQPRDINIVSSIPRNPTGKVLRKEL 514
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
38-521 |
2.07e-34 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 143.76 E-value: 2.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 38 KTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVhalcqi 117
Cdd:PRK12467 528 RPALVFGEQVLSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEYPQDRL------ 601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 arpvAYIIPDC--------IHGFDYREMAREVAASCPELEHIIVDGEAEEFIPFAsiedeplniIGPGygDIAVLLLSGG 189
Cdd:PRK12467 602 ----AYMLDDSgvrllltqSHLLAQLPVPAGLRSLCLDEPADLLCGYSGHNPEVA---------LDPD--NLAYVIYTSG 666
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 190 TTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLLSD---TASCDEAMPLIE 266
Cdd:PRK12467 667 STGQPKGVAISHGALANYVCVIAERLQLAADDSMLMVSTFA--FDLGVTELFGALASGATLHLLPpdcARDAEAFAALMA 744
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 267 EHKVTHLALVPALARLWEQARdwEQSDLSSLRCLQVGGGRLTPELAEQVMArLGPLQQVFG------TAEGLLCYTRLDD 340
Cdd:PRK12467 745 DQGVTVLKIVPSHLQALLQAS--RVALPRPQRALVCGGEALQVDLLARVRA-LGPGARLINhygpteTTVGVSTYELSDE 821
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 PYEVIINTQGRPLsEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYR-----AEQHNTVAFTTDG--FYRTGDLVRI 413
Cdd:PRK12467 822 ERDFGNVPIGQPL-ANLGLYILDHYLNPVPVGVVGELYIGGAGLARGYHRrpaltAERFVPDPFGADGgrLYRTGDLARY 900
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSInqPDPAQMQAFLH--QK 491
Cdd:PRK12467 901 RADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVREAVVLAQPGDAGLQLVAYLVPAAV--ADGAEHQATRDelKA 978
|
490 500 510
....*....|....*....|....*....|....
gi 2740590833 492 GVQR----HKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK12467 979 QLRQvlpdYMVPAHLLLLDSLPLTPNGKLDRKAL 1012
|
|
| AFD_YhfT-like |
cd17633 |
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ... |
186-516 |
3.02e-34 |
|
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain
Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 134.07 E-value: 3.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGspGILGTLSQGGCVLLSDTASCDEAMPLI 265
Cdd:cd17633 7 FTSGTTGLPKAYYRSERSWIESFVCNEDLFNISGEDAILAPGPLSHSLFLY--GAISALYLGGTFIGQRKFNPKSWIRKI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 266 EEHKVTHLALVP----ALARlweqardwEQSDLSSLRCLQVGGGRLtPELAEQVMARLGP---LQQVFGTAE----GLLC 334
Cdd:cd17633 85 NQYNATVIYLVPtmlqALAR--------TLEPESKIKSIFSSGQKL-FESTKKKLKNIFPkanLIEFYGTSElsfiTYNF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 YTRLDDPyeviiNTQGRPLSE-EDEINLADTNlqpvapsEVGELITRGPYTITGYYRAEQHNTvafttDGFYRTGDLVRI 413
Cdd:cd17633 156 NQESRPP-----NSVGRPFPNvEIEIRNADGG-------EIGKIFVKSEMVFSGYVRGGFSNP-----DGWMSVGDIGYV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLpkSINQPDPAQMQAFLHQKgV 493
Cdd:cd17633 219 DEEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIAVALY--SGDKLTYKQLKRFLKQK-L 295
|
330 340
....*....|....*....|...
gi 2740590833 494 QRHKIPDQWLFVAYWPLTAVGKI 516
Cdd:cd17633 296 SRYEIPKKIIFVDSLPYTSSGKI 318
|
|
| PRK13382 |
PRK13382 |
bile acid CoA ligase; |
38-521 |
3.99e-34 |
|
bile acid CoA ligase;
Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 138.35 E-value: 3.99e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 38 KTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQI 117
Cdd:PRK13382 59 RPGLIDELGTLTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRIGADILLLNTSFAGPALAEVVTR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 ARPVAYIIPDcihgfDYREMAREVAASCPELEHIIVDGEAEEFIPFASIEDEPLN---IIGPGYGDiaVLLLSGGTTGTP 194
Cdd:PRK13382 139 EGVDTVIYDE-----EFSATVDRALADCPQATRIVAWTDEDHDLTVEVLIAAHAGqrpEPTGRKGR--VILLTSGTTGTP 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 195 KLIPRTHDAyTYNfVLSARLCAI--NTESVYLAVLPVAHNFilGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTH 272
Cdd:PRK13382 212 KGARRSGPG-GIG-TLKAILDRTpwRAEEPTVIVAPMFHAW--GFSQLVLAASLACTIVTRRRFDPEATLDLIDRHRATG 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVPALAR----LWEQARDweQSDLSSLRCLQVGGGRLTPELAEQVMARLGP-LQQVFGTAEGLLCYTRLDDPYEVIIN 347
Cdd:PRK13382 288 LAVVPVMFDrimdLPAEVRN--RYSGRSLRFAAASGSRMRPDVVIAFMDQFGDvIYNNYNATEAGMIATATPADLRAAPD 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 348 TQGRPlSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVafttDGFYRTGDLVRIRPDGNLLVEGRIKE 427
Cdd:PRK13382 366 TAGRP-AEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGYTSGSTKDFH----DGFMASGDVGYLDENGRLFVVGRDDE 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 428 QINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLpksINQPDPAQMQAFLHQ---KGVQRHKIPDQWLF 504
Cdd:PRK13382 441 MIVSGGENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQRLAAFV---VLKPGASATPETLKQhvrDNLANYKVPRDIVV 517
|
490
....*....|....*..
gi 2740590833 505 VAYWPLTAVGKINKRQL 521
Cdd:PRK13382 518 LDELPRGATGKILRREL 534
|
|
| A_NRPS_SidN3_like |
cd05918 |
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ... |
37-527 |
8.59e-34 |
|
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 136.52 E-value: 8.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQ 116
Cdd:cd05918 14 DAPAVCAWDGSLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDPSHPLQRLQEILQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 IARpvayiipdcihgfdyremAREVAASCPElehiivdgeaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKL 196
Cdd:cd05918 94 DTG------------------AKVVLTSSPS--------------------------------DAAYVIFTSGSTGKPKG 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAYTYNFVLSARLCAINTESVYL--AvlpvAHNF---ILGspgILGTLSQGGCV-------LLSDTASCdeampl 264
Cdd:cd05918 124 VVIEHRALSTSALAHGRALGLTSESRVLqfA----SYTFdvsILE---IFTTLAAGGCLcipseedRLNDLAGF------ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 265 IEEHKVTHLALVPALARLWEQardweqSDLSSLRCLQVGGGRLTPELAEQVMARLGpLQQVFGTAEGLLCYTRLDDPYEV 344
Cdd:cd05918 191 INRLRVTWAFLTPSVARLLDP------EDVPSLRTLVLGGEALTQSDVDTWADRVR-LINAYGPAECTIAATVSPVVPST 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 345 IINTQGRPLS------EEDEINladtnlQPVAPSEVGELITRGPYTITGYYRAEQHNTVAF-----------TTDG--FY 405
Cdd:cd05918 264 DPRNIGRPLGatcwvvDPDNHD------RLVPIGAVGELLIEGPILARGYLNDPEKTAAAFiedpawlkqegSGRGrrLY 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 406 RTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAV---PDELLGERICACL---------- 472
Cdd:cd05918 338 RTGDLVRYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHLRQSLPGAKEVVVEVvkpKDGSSSPQLVAFVvldgsssgsg 417
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2740590833 473 --------PKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQA 527
Cdd:cd05918 418 dgdslflePSDEFRALVAELRSKLRQR-LPSYMVPSVFLPLSHLPLTASGKIDRRALRELAES 479
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
40-521 |
1.02e-33 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 141.45 E-value: 1.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvhalcq 116
Cdd:PRK12467 3113 ALVFGDQQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLdpeYPRER--------- 3183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 iarpVAYIIPDCihGFDYREMAREVAASCPELEH---IIVDGEAEEFIPfasiEDEPLNIIGPGygDIAVLLLSGGTTGT 193
Cdd:PRK12467 3184 ----LAYMIEDS--GVKLLLTQAHLLEQLPAPAGdtaLTLDRLDLNGYS----ENNPSTRVMGE--NLAYVIYTSGSTGK 3251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 194 PKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLLSDTASCD--EAMPLIEEHKVT 271
Cdd:PRK12467 3252 PKGVGVRHGALANHLCWIAEAYELDANDRVLLFMSFS--FDGAQERFLWTLICGGCLVVRDNDLWDpeELWQAIHAHRIS 3329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPALarLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP--LQQVFGTAEGLLCYTRLDDPYEVIINTQ 349
Cdd:PRK12467 3330 IACFPPAY--LQQFAEDAGGADCASLDIYVFGGEAVPPAAFEQVKRKLKPrgLTNGYGPTEAVVTVTLWKCGGDAVCEAP 3407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 350 ----GRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYR-----AEQHNTVAFTTDG--FYRTGDLVRIRPDGN 418
Cdd:PRK12467 3408 yapiGRPVAGR-SIYVLDGQLNPVPVGVAGELYIGGVGLARGYHQrpsltAERFVADPFSGSGgrLYRTGDLARYRADGV 3486
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 419 LLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDElLGERICACLPKSINQPDPAQMQAFLHQKGVQRHKI 498
Cdd:PRK12467 3487 IEYLGRIDHQVKIRGFRIELGEIEARLLQHPSVREAVVLARDGA-GGKQLVAYVVPADPQGDWRETLRDHLAASLPDYMV 3565
|
490 500
....*....|....*....|...
gi 2740590833 499 PDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK12467 3566 PAQLLVLAAMPLGPNGKVDRKAL 3588
|
|
| AACS_like |
cd05968 |
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ... |
25-519 |
1.10e-33 |
|
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.
Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 138.01 E-value: 1.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 25 DQQLAGWSSIWGNKTALIY-----HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhp 99
Cdd:cd05968 64 EQLLDKWLADTRTRPALRWegedgTSRTLTYGELLYEVKRLANGLRALGVGKGDRVGIYLPMIPEIVPAFLAVARIGG-- 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 100 vLLMPTQRAHDVHALC---QIARPVAYIIPDcihGF-------DYREMAREVAASCPELEHIIVDGEAEEFIPFASIED- 168
Cdd:cd05968 142 -IVVPIFSGFGKEAAAtrlQDAEAKALITAD---GFtrrgrevNLKEEADKACAQCPTVEKVVVVRHLGNDFTPAKGRDl 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 169 -EPLNIIGPGYG-------DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCA-INTESVYLAVLPVAhnFILGSPG 239
Cdd:cd05968 218 sYDEEKETAGDGaerteseDPLMIIYTSGTTGKPKGTVHVHAGFPLKAAQDMYFQFdLKPGDLLTWFTDLG--WMMGPWL 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 240 ILGTLSQGGCVLLSDTA----SCDEAMPLIEEHKVTHLALVPALAR-LWEQARDW-EQSDLSSLRCLQVGGGRLTPE--- 310
Cdd:cd05968 296 IFGGLILGATMVLYDGApdhpKADRLWRMVEDHEITHLGLSPTLIRaLKPRGDAPvNAHDLSSLRVLGSTGEPWNPEpwn 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 311 -LAEQVMARLGPLQQVFGTAE---GLLCYTRLDDPYEVIINTqgrPLSEEDEINLaDTNLQPVAPsEVGELITRGPY--T 384
Cdd:cd05968 376 wLFETVGKGRNPIINYSGGTEisgGILGNVLIKPIKPSSFNG---PVPGMKADVL-DESGKPARP-EVGELVLLAPWpgM 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 385 ITGYYRAEQ--HNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDE 462
Cdd:cd05968 451 TRGFWRDEDryLETYWSRFDNVWVHGDFAYYDEEGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHP 530
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 463 LLGERI-CACLPKSINQPDPAQMQAFLhqKGVQRHK----IPDQWLFVAYWPLTAVGKINKR 519
Cdd:cd05968 531 VKGEAIvCFVVLKPGVTPTEALAEELM--ERVADELgkplSPERILFVKDLPKTRNAKVMRR 590
|
|
| caiC |
PRK08008 |
putative crotonobetaine/carnitine-CoA ligase; Validated |
21-521 |
1.28e-33 |
|
putative crotonobetaine/carnitine-CoA ligase; Validated
Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 136.74 E-value: 1.28e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 21 GKTLDQQLAGWSSIWGNKTALIYHE-----QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRL 95
Cdd:PRK08008 6 GQHLRQMWDDLADVYGHKTALIFESsggvvRRYSYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 96 GAhpvLLMPTQrAHDVHALCqiarpvAYIIPDCIHGF---------DYREMAREVAAScpeLEHIIVDGEAEEFIP---- 162
Cdd:PRK08008 86 GA---IMVPIN-ARLLREES------AWILQNSQASLlvtsaqfypMYRQIQQEDATP---LRHICLTRVALPADDgvss 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 163 FASIEDE---------PLNIigpgyGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAH-N 232
Cdd:PRK08008 153 FTQLKAQqpatlcyapPLST-----DDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHiD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 233 FILGSpgILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALAR--LWEQARDWEQSdlsslRCLqvgggR---- 306
Cdd:PRK08008 228 CQCTA--AMAAFSAGATFVLLEKYSARAFWGQVCKYRATITECIPMMIRtlMVQPPSANDRQ-----HCL-----Revmf 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 307 ---LTPELAEQVMARLG-PLQQVFGTAE---GLLCytrlDDP-----YEVIintqGRP-LSEEDEInlADTNLQPVAPSE 373
Cdd:PRK08008 296 ylnLSDQEKDAFEERFGvRLLTSYGMTEtivGIIG----DRPgdkrrWPSI----GRPgFCYEAEI--RDDHNRPLPAGE 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 374 VGELITRG-P-YTI-TGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPD 450
Cdd:PRK08008 366 IGEICIKGvPgKTIfKEYYLDPKATAKVLEADGWLHTGDTGYVDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPK 445
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 451 IDDTVVIAVPDELLGERICA-CLPKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK08008 446 IQDIVVVGIKDSIRDEAIKAfVVLNEGETLSEEEFFAFCEQN-MAKFKVPSYLEIRKDLPRNCSGKIIKKNL 516
|
|
| PrpE |
cd05967 |
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ... |
36-529 |
2.45e-33 |
|
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 137.06 E-value: 2.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIY------HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA-HPVLLMPTQrA 108
Cdd:cd05967 65 GDQIALIYdspvtgTERTYTYAELLDEVSRLAGVLRKLGVVKGDRVIIYMPMIPEAAIAMLACARIGAiHSVVFGGFA-A 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 109 HDVHALCQIARPVAYIIPDCihGF------DYREM---AREVAASCPEleHIIV----DGEAE----------------- 158
Cdd:cd05967 144 KELASRIDDAKPKLIVTASC--GIepgkvvPYKPLldkALELSGHKPH--HVLVlnrpQVPADltkpgrdldwsellaka 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 159 EFIPFASIE-DEPLNIigpgygdiavlLLSGGTTGTPKLIPRTHDAYTYNFVLSARLC-AINTESVYLA------VlpVA 230
Cdd:cd05967 220 EPVDCVPVAaTDPLYI-----------LYTSGTTGKPKGVVRDNGGHAVALNWSMRNIyGIKPGDVWWAasdvgwV--VG 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 231 HNFILGSPGILGTLS---QGGCVllsDTASCDEAMPLIEEHKVTHLALVP----ALARLWEQARDWEQSDLSSLRCLQVG 303
Cdd:cd05967 287 HSYIVYGPLLHGATTvlyEGKPV---GTPDPGAFWRVIEKYQVNALFTAPtairAIRKEDPDGKYIKKYDLSSLRTLFLA 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 304 GGRLTPELAEQVMARLG-P-LQQVFGTAEG--LLCYTRLDDPYEVIINTQGRPLSEEDeINLADTNLQPVAPSEVGELIT 379
Cdd:cd05967 364 GERLDPPTLEWAENTLGvPvIDHWWQTETGwpITANPVGLEPLPIKAGSPGKPVPGYQ-VQVLDEDGEPVGPNELGNIVI 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 380 RGPY---TITGYYRaeqhNTVAFTT------DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPD 450
Cdd:cd05967 443 KLPLppgCLLTLWK----NDERFKKlylskfPGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESVLSHPA 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 451 IDDTVVIAVPDELLGER-ICACLPKSINQPDPAQMQAFLHQkgVQRHKI-----PDQWLFVAYWPLTAVGKINKRQLVQM 524
Cdd:cd05967 519 VAECAVVGVRDELKGQVpLGLVVLKEGVKITAEELEKELVA--LVREQIgpvaaFRLVIFVKRLPKTRSGKILRRTLRKI 596
|
....*
gi 2740590833 525 AQAEN 529
Cdd:cd05967 597 ADGED 601
|
|
| A_NRPS_PpsD_like |
cd17650 |
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ... |
37-521 |
3.72e-33 |
|
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 134.13 E-value: 3.72e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhalcq 116
Cdd:cd17650 2 DAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGG------------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 iarpvAYIIPDCihgfDYrEMARevaascpeLEHIIVDGEAeefipfasiedePLNIIGPGygDIAVLLLSGGTTGTPKL 196
Cdd:cd17650 63 -----AYVPIDP----DY-PAER--------LQYMLEDSGA------------KLLLTQPE--DLAYVIYTSGTTGKPKG 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAYTYnfvlsarlCAINTESVY-LAVLPVAH------NFILGSPGILGTLSQGGC-VLLSDTASCDEAM--PLIE 266
Cdd:cd17650 111 VMVEHRNVAH--------AAHAWRREYeLDSFPVRLlqmasfSFDVFAGDFARSLLNGGTlVICPDEVKLDPAAlyDLIL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 267 EHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQV---FGTAEGLL---CYTRLDD 340
Cdd:cd17650 183 KSRITLMESTPALIRPVMAYVYRNGLDLSAMRLLIVGSDGCKAQDFKTLAARFGQGMRIinsYGVTEATIdstYYEEGRD 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 PYEVIINTQ-GRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRI 413
Cdd:cd17650 263 PLGDSANVPiGRPLPNT-AMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERFVENPFapgermYRTGDLARW 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA-CLPKSinQPDPAQMQAFLHQKg 492
Cdd:cd17650 342 RADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDEAVVAVREDKGGEARLCAyVVAAA--TLNTAELRAFLAKE- 418
|
490 500
....*....|....*....|....*....
gi 2740590833 493 VQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17650 419 LPSYMIPSYYVQLDALPLTPNGKVDRRAL 447
|
|
| FadD3 |
cd17638 |
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ... |
180-518 |
5.38e-33 |
|
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.
Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 130.70 E-value: 5.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSpGILGTLSQGGCVLLSDTASCD 259
Cdd:cd17638 1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDDRYLIINPFFHTFGYKA-GIVACLLTGATVVPVAVFDVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 260 EAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGpLQQVFgTAEGL------- 332
Cdd:cd17638 80 AILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMRSELG-FETVL-TAYGLteagvat 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 333 LCytRLDDPYEVIINTQGRPLSEEdEINLADTnlqpvapsevGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVR 412
Cdd:cd17638 158 MC--RPGDDAETVATTCGRACPGF-EVRIADD----------GEVLVRGYNVMQGYLDDPEATAEAIDADGWLHTGDVGE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 413 IRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL----PKSINQPDpaqMQAFL 488
Cdd:cd17638 225 LDERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVvarpGVTLTEED---VIAWC 301
|
330 340 350
....*....|....*....|....*....|
gi 2740590833 489 HQKgVQRHKIPDQWLFVAYWPLTAVGKINK 518
Cdd:cd17638 302 RER-LANYKVPRFVRFLDELPRNASGKVMK 330
|
|
| PLN02246 |
PLN02246 |
4-coumarate--CoA ligase |
48-466 |
8.53e-33 |
|
4-coumarate--CoA ligase
Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 134.34 E-value: 8.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHAlcQIARPVAYIIpd 127
Cdd:PLN02246 51 YTYADVELLSRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTANPFYTPAEIAK--QAKASGAKLI-- 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 cIHGFDYREMAREVAAScPELEHIIVDGEAEEFIPF-----ASIEDEPLNIIGPgyGDIAVLLLSGGTTGTPKLIPRTH- 201
Cdd:PLN02246 127 -ITQSCYVDKLKGLAED-DGVTVVTIDDPPEGCLHFseltqADENELPEVEISP--DDVVALPYSSGTTGLPKGVMLTHk 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 202 ----------DAYTYNFVLSArlcaintESVYLAVLPVAHNFILGSPgILGTLSQGGCVLLSDTASCDEAMPLIEEHKVT 271
Cdd:PLN02246 203 glvtsvaqqvDGENPNLYFHS-------DDVILCVLPMFHIYSLNSV-LLCGLRVGAAILIMPKFEIGALLELIQRHKVT 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLgPlQQVFGTAEGL--------LCYTRLDDPYE 343
Cdd:PLN02246 275 IAPFVPPIVLAIAKSPVVEKYDLSSIRMVLSGAAPLGKELEDAFRAKL-P-NAVLGQGYGMteagpvlaMCLAFAKEPFP 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 --------VIINTQGRPLSEEDEINLADTnlQPvapsevGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRP 415
Cdd:PLN02246 353 vksgscgtVVRNAELKIVDPETGASLPRN--QP------GEICIRGPQIMKGYLNDPEATANTIDKDGWLHTGDIGYIDD 424
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2740590833 416 DGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGE 466
Cdd:PLN02246 425 DDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVVPMKDEVAGE 475
|
|
| PRK06710 |
PRK06710 |
long-chain-fatty-acid--CoA ligase; Validated |
19-531 |
1.07e-32 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 134.39 E-value: 1.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 19 WNGKTLDQQLAGWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAH 98
Cdd:PRK06710 21 YDIQPLHKYVEQMASRYPEKKALHFLGKDITFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAGGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 99 PVLLMP--TQRA-----HDVHA---LCqiarpVAYIIPDCIHgfdyremarevAASCPELEHIIVDGEAEeFIPFA---- 164
Cdd:PRK06710 101 VVQTNPlyTEREleyqlHDSGAkviLC-----LDLVFPRVTN-----------VQSATKIEHVIVTRIAD-FLPFPknll 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 165 -------------------------SIEDE---PLNIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLC- 215
Cdd:PRK06710 164 ypfvqkkqsnlvvkvsesetihlwnSVEKEvntGVEVPCDPENDLALLQYTGGTTGFPKGVMLTHKNLVSNTLMGVQWLy 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 216 -AINTESVYLAVLPVAHnfILGSPGILG-TLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSD 293
Cdd:PRK06710 244 nCKEGEEVVLGVLPFFH--VYGMTAVMNlSIMQGYKMVLIPKFDMKMVFEAIKKHKVTLFPGAPTIYIALLNSPLLKEYD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 294 LSSLRCLQVGGGRLTPELAEQV-MARLGPLQQVFGTAEGLLCyTRLDDPYEV-IINTQGRPLSEEDEINLADTNLQPVAP 371
Cdd:PRK06710 322 ISSIRACISGSAPLPVEVQEKFeTVTGGKLVEGYGLTESSPV-THSNFLWEKrVPGSIGVPWPDTEAMIMSLETGEALPP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 372 SEVGELITRGPYTITGYYRAEQHnTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDI 451
Cdd:PRK06710 401 GEIGEIVVKGPQIMKGYWNKPEE-TAAVLQDGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEVLYEHEKV 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 452 DDTVVIAVPDELLGERICA-CLPKSINQPDPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENT 530
Cdd:PRK06710 480 QEVVTIGVPDPYRGETVKAfVVLKEGTECSEEELNQFA-RKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIEEEKRKNE 558
|
.
gi 2740590833 531 E 531
Cdd:PRK06710 559 D 559
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
37-521 |
1.44e-32 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 137.60 E-value: 1.44e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvha 113
Cdd:PRK12467 1589 EAVALVFGEQELTYGELNRRANRLAHRLIALGVGPEVLVGIAVERSLEMVVGLLAILKAGGAYVPLdpeYPRER------ 1662
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 lcqiarpVAYIIPDCihGFDYREMAREVAASCP---ELEHIIVDGEAEEFIPFAsiEDEPLNIIGPGygDIAVLLLSGGT 190
Cdd:PRK12467 1663 -------LAYMIEDS--GIELLLTQSHLQARLPlpdGLRSLVLDQEDDWLEGYS--DSNPAVNLAPQ--NLAYVIYTSGS 1729
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 191 TGTPKLIPRTHDAytynfvLSARLCA------INTESVYLAVLPVAHNFILGspGILGTLSQGGCVLLSDTA---SCDEA 261
Cdd:PRK12467 1730 TGRPKGAGNRHGA------LVNRLCAtqeayqLSAADVVLQFTSFAFDVSVW--ELFWPLINGARLVIAPPGahrDPEQL 1801
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 262 MPLIEEHKVTHLALVP-ALARLWEQARDWEQSdlSSLRCLQVGGGRLTPELAEQVMARLGP--LQQVFGTAEGLLCYT-- 336
Cdd:PRK12467 1802 IQLIERQQVTTLHFVPsMLQQLLQMDEQVEHP--LSLRRVVCGGEALEVEALRPWLERLPDtgLFNLYGPTETAVDVThw 1879
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 --RLDDPYEVIINTQGRPLSeedeiNLA----DTNLQPVAPSEVGELITRGPYTITGYYR-----AEQHNTVAFTTDG-- 403
Cdd:PRK12467 1880 tcRRKDLEGRDSVPIGQPIA-----NLStyilDASLNPVPIGVAGELYLGGVGLARGYLNrpaltAERFVADPFGTVGsr 1954
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 404 FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVpDELLGERICACL-PKSINQPDPA 482
Cdd:PRK12467 1955 LYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLREQGGVREAVVIAQ-DGANGKQLVAYVvPTDPGLVDDD 2033
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 2740590833 483 QMQAFLH-------QKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK12467 2034 EAQVALRailknhlKASLPEYMVPAHLVFLARMPLTPNGKLDRKAL 2079
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
39-541 |
2.24e-32 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 137.01 E-value: 2.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIA 118
Cdd:PRK12316 528 PALAFGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDPEYPAERLAYMLEDS 607
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 119 RpVAYIIPDCiHGFDYREMAREVAASCPELEHIIVDGEAEEFipfASIEDEPLNIigpgygdiAVLLLSGGTTGTPKLIP 198
Cdd:PRK12316 608 G-VQLLLSQS-HLGRKLPLAAGVQVLDLDRPAAWLEGYSEEN---PGTELNPENL--------AYVIYTSGSTGKPKGAG 674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 199 RTHDAytynfvLSARLCAINT-------ESVyLAVLPVAhnFILGSPGILGTLSQGGCVLLS---DTASCDEAMPLIEEH 268
Cdd:PRK12316 675 NRHRA------LSNRLCWMQQayglgvgDTV-LQKTPFS--FDVSVWEFFWPLMSGARLVVAapgDHRDPAKLVELINRE 745
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 269 KVTHLALVPALARLWEQARDweQSDLSSLRCLQVGGGRLTPELAEQVMARL--GPLQQVFGTAE---GLLCYTRLDDPYE 343
Cdd:PRK12316 746 GVDTLHFVPSMLQAFLQDED--VASCTSLRRIVCSGEALPADAQEQVFAKLpqAGLYNLYGPTEaaiDVTHWTCVEEGGD 823
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 VIinTQGRPLSeedeiNLA----DTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRI 413
Cdd:PRK12316 824 SV--PIGRPIA-----NLAcyilDANLEPVPVGVLGELYLAGRGLARGYHGRPGLTAERFVPSPFvagermYRTGDLARY 896
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLgerICACLPKSINQPDPAQMQAFLHQKgV 493
Cdd:PRK12316 897 RADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAVDGKQL---VGYVVLESEGGDWREALKAHLAAS-L 972
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 2740590833 494 QRHKIPDQWLFVAYWPLTAVGKINKRQL--VQMAQAENTETAENNSLMKQ 541
Cdd:PRK12316 973 PEYMVPAQWLALERLPLTPNGKLDRKALpaPEASVAQQGYVAPRNALERT 1022
|
|
| Firefly_Luc |
cd17642 |
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ... |
45-524 |
4.08e-32 |
|
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 132.27 E-value: 4.08e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 45 EQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA--HPVLLMPTQRAHDvHALcQIARPVa 122
Cdd:cd17642 42 GVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENSLQFFLPVIAGLFIGVgvAPTNDIYNERELD-HSL-NISKPT- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 123 yIIPDCIHGFDyreMAREVAASCPELEHIIVDGEAEEFIPFASIEDEPLNIIGPGYG-------------DIAVLLLSGG 189
Cdd:cd17642 119 -IVFCSKKGLQ---KVLNVQKKLKIIKTIIILDSKEDYKGYQCLYTFITQNLPPGFNeydfkppsfdrdeQVALIMNSSG 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 190 TTGTPKLIPRTHDAYTYNFVlSAR----LCAINTESVYLAVLPVAHNFilGSPGILGTLSQGGCVLLSDTASCDEAMPLI 265
Cdd:cd17642 195 STGLPKGVQLTHKNIVARFS-HARdpifGNQIIPDTAILTVIPFHHGF--GMFTTLGYLICGFRVVLMYKFEEELFLRSL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 266 EEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-P-LQQVFGTAEGLLCytrlddpye 343
Cdd:cd17642 272 QDYKVQSALLVPTLFAFFAKSTLVDKYDLSNLHEIASGGAPLSKEVGEAVAKRFKlPgIRQGYGLTETTSA--------- 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 VIINTQG----------RPLSEEDEINLaDTNlQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRI 413
Cdd:cd17642 343 ILITPEGddkpgavgkvVPFFYAKVVDL-DTG-KTLGPNERGELCVKGPMIMKGYVNNPEATKALIDKDGWLHSGDIAYY 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQpdpaQMQAFLHQKGV 493
Cdd:cd17642 421 DEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPKIFDAGVAGIPDEDAGELPAAVVVLEAGK----TMTEKEVMDYV 496
|
490 500 510
....*....|....*....|....*....|....*.
gi 2740590833 494 QRHKIPDQWL-----FVAYWPLTAVGKINKRQLVQM 524
Cdd:cd17642 497 ASQVSTAKRLrggvkFVDEVPKGLTGKIDRRKIREI 532
|
|
| A_NRPS_ApnA-like |
cd17644 |
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ... |
40-521 |
1.14e-31 |
|
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 129.86 E-value: 1.14e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvhalcq 116
Cdd:cd17644 18 AVVFEDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLdpnYPQER--------- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 iarpVAYIIPDCihgfdyremarevaascpELEHIIVDGEaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKL 196
Cdd:cd17644 89 ----LTYILEDA------------------QISVLLTQPE-----------------------NLAYVIYTSGSTGKPKG 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAY-TYNFVLSARLCAINTESVylaVLPVAHNFILGSPGILGTLSQGGCVLLSDT---ASCDEAMPLIEEHKVTH 272
Cdd:cd17644 124 VMIEHQSLvNLSHGLIKEYGITSSDRV---LQFASIAFDVAAEEIYVTLLSGATLVLRPEemrSSLEDFVQYIQQWQLTV 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVPALARLWEQARDWEQSDL-SSLRCLQVGGGRLTPELAEQVMARLGPLQQ---VFGTAEGLLCYT--RLDDPYEVII 346
Cdd:cd17644 201 LSLPPAYWHLLVLELLLSTIDLpSSLRLVIVGGEAVQPELVRQWQKNVGNFIQlinVYGPTEATIAATvcRLTQLTERNI 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 347 N--TQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF--------YRTGDLVRIRPD 416
Cdd:cd17644 281 TsvPIGRPIANT-QVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHPFnsseserlYKTGDLARYLPD 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 417 GNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQR 495
Cdd:cd17644 360 GNIEYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKTAVVIVREDQPGNKRLVAYIvPHYEESPSTVELRQFLKAK-LPD 438
|
490 500
....*....|....*....|....*.
gi 2740590833 496 HKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17644 439 YMIPSAFVVLEELPLTPNGKIDRRAL 464
|
|
| A_NRPS_TubE_like |
cd05906 |
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ... |
44-521 |
2.06e-31 |
|
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 130.09 E-value: 2.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 44 HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMP----TQRAHDVHALCQI-- 117
Cdd:cd05906 36 SEEFQSYQDLLEDARRLAAGLRQLGLRPGDSVILQFDDNEDFIPAFWACVLAGFVPAPLTVpptyDEPNARLRKLRHIwq 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 --ARPVayIIPDCihgfdyrEMAREVAAScPELEHIIVDGEAEEFIPFASIEDEPLNIIGPGygDIAVLLLSGGTTGTPK 195
Cdd:cd05906 116 llGSPV--VLTDA-------ELVAEFAGL-ETLSGLPGIRVLSIEELLDTAADHDLPQSRPD--DLALLMLTSGSTGFPK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 196 LIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSqgGC--------VLLSDTAscdEAMPLIEE 267
Cdd:cd05906 184 AVPLTHRNILARSAGKIQHNGLTPQDVFLNWVPLDHVGGLVELHLRAVYL--GCqqvhvpteEILADPL---RWLDLIDR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 268 HKVTHlALVP--ALARLWEQARDWEQS--DLSSLRCLQVGGGRLTPELAEQVMARLGPLQ-------QVFGTAEglLC-- 334
Cdd:cd05906 259 YRVTI-TWAPnfAFALLNDLLEEIEDGtwDLSSLRYLVNAGEAVVAKTIRRLLRLLEPYGlppdairPAFGMTE--TCsg 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 --YTRlDDPYEVIINTQ-----GRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRT 407
Cdd:cd05906 336 viYSR-SFPTYDHSQALefvslGRPIPGVS-MRIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNNPEANAEAFTEDGWFRT 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 408 GDLVRIRpDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLG---ERICACLPKSINQPDP--A 482
Cdd:cd05906 414 GDLGFLD-NGNLTITGRTKDTIIVNGVNYYSHEIEAAVEEVPGVEPSFTAAFAVRDPGaetEELAIFFVPEYDLQDAlsE 492
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 2740590833 483 QMQAF----LHQKGVQR-HKIPdqwLFVAYWPLTAVGKINKRQL 521
Cdd:cd05906 493 TLRAIrsvvSREVGVSPaYLIP---LPKEEIPKTSLGKIQRSKL 533
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
39-541 |
2.81e-31 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 133.54 E-value: 2.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvhalc 115
Cdd:PRK12316 2020 IAVVFGDQHLSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLdpnYPAER-------- 2091
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 qiarpVAYIIPDCihGFDYREMAREVAASCP---ELEHIIVDGEAEEFipfASIEDEPLNIIGPGygDIAVLLLSGGTTG 192
Cdd:PRK12316 2092 -----LAYMLEDS--GAALLLTQRHLLERLPlpaGVARLPLDRDAEWA---DYPDTAPAVQLAGE--NLAYVIYTSGSTG 2159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 193 TPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLLSDTA--SCDEAMPLIEEHKV 270
Cdd:PRK12316 2160 LPKGVAVSHGALVAHCQAAGERYELSPADCELQFMSFS--FDGAHEQWFHPLLNGARVLIRDDElwDPEQLYDEMERHGV 2237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 271 THLALVPA-LARLWEQARdwEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP--LQQVFGTAEG----LLCYTRLDDPYE 343
Cdd:PRK12316 2238 TILDFPPVyLQQLAEHAE--RDGRPPAVRVYCFGGEAVPAASLRLAWEALRPvyLFNGYGPTEAvvtpLLWKCRPQDPCG 2315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 VIINTQGRPLSEEDEINLaDTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF-------YRTGDLVRIRPD 416
Cdd:PRK12316 2316 AAYVPIGRALGNRRAYIL-DADLNLLAPGMAGELYLGGEGLARGYLNRPGLTAERFVPDPFsasgerlYRTGDLARYRAD 2394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 417 GNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVpDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQR 495
Cdd:PRK12316 2395 GVVEYLGRIDHQVKIRGFRIELGEIEARLQAHPAVREAVVVAQ-DGASGKQLVAYVvPDDAAEDLLAELRAWLAAR-LPA 2472
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 2740590833 496 HKIPDQWLFVAYWPLTAVGKINKRQL--VQMAQAENTETAENNSLMKQ 541
Cdd:PRK12316 2473 YMVPAHWVVLERLPLNPNGKLDRKALpkPDVSQLRQAYVAPQEGLEQR 2520
|
|
| PRK08162 |
PRK08162 |
acyl-CoA synthetase; Validated |
34-528 |
5.06e-31 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 129.30 E-value: 5.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 34 IWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpVLlmptqrahdvHA 113
Cdd:PRK08162 30 VYPDRPAVIHGDRRRTWAETYARCRRLASALARRGIGRGDTVAVLLPNIPAMVEAHFGVPMAGA--VL----------NT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 LcQI---ARPVAYIIPdciHG--------FDYREMAREVAASCPELEHIIV---DGEAEEFIPFASIEDEPLNIIG-PGY 178
Cdd:PRK08162 98 L-NTrldAASIAFMLR---HGeakvlivdTEFAEVAREALALLPGPKPLVIdvdDPEYPGGRFIGALDYEAFLASGdPDF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 179 G--------DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILgTLSQGGCV 250
Cdd:PRK08162 174 AwtlpadewDAIALNYTSGTTGNPKGVVYHHRGAYLNALSNILAWGMPKHPVYLWTLPMFHCNGWCFPWTV-AARAGTNV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 LLSDtASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQvMARLG-PLQQVFGTA 329
Cdd:PRK08162 253 CLRK-VDPKLIFDLIREHGVTHYCGAPIVLSALINAPAEWRAGIDHPVHAMVAGAAPPAAVIAK-MEEIGfDLTHVYGLT 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 330 E----GLLC-----YTRLDDPYEVIINT-QGRPLSEEDEINLADTN-LQPVaPSE---VGELITRGPYTITGYYRAEQHN 395
Cdd:PRK08162 331 EtygpATVCawqpeWDALPLDERAQLKArQGVRYPLQEGVTVLDPDtMQPV-PADgetIGEIMFRGNIVMKGYLKNPKAT 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 396 TVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLP-K 474
Cdd:PRK08162 410 EEAFA-GGWFHTGDLAVLHPDGYIKIKDRSKDIIISGGENISSIEVEDVLYRHPAVLVAAVVAKPDPKWGEVPCAFVElK 488
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 2740590833 475 SINQPDPAQMQAFLhQKGVQRHKIPDQWLFVAYwPLTAVGKINKRQLVQMAQAE 528
Cdd:PRK08162 489 DGASATEEEIIAHC-REHLAGFKVPKAVVFGEL-PKTSTGKIQKFVLREQAKSL 540
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
40-564 |
7.88e-31 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 132.00 E-value: 7.88e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVhalcqiar 119
Cdd:PRK12316 3075 ALAFGEQRLSYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEMVVGLLAILKAGGAYVPLDPEYPEERL-------- 3146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 120 pvAYIIPDCihGFDYREMAREVA-ASCPELEHIIVDGEAEEfipfASIEDEPLNIIGPgygDIAVLLLSGGTTGTPKLIP 198
Cdd:PRK12316 3147 --AYMLEDS--GAQLLLSQSHLRlPLAQGVQVLDLDRGDEN----YAEANPAIRTMPE---NLAYVIYTSGSTGKPKGVG 3215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 199 RTHDAYTYNFVLSARLCAINTESVYLAVLPVahNFILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPA 278
Cdd:PRK12316 3216 IRHSALSNHLCWMQQAYGLGVGDRVLQFTTF--SFDVFVEELFWPLMSGARVVLAGPEDWRDPALLVELINSEGVDVLHA 3293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 279 LARLWEQA-RDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLgPLQQVFGTAEGLLCYTRLDDPYE-VIINTQGRPLSEE 356
Cdd:PRK12316 3294 YPSMLQAFlEEEDAHRCTSLKRIVCGGEALPADLQQQVFAGL-PLYNLYGPTEATITVTHWQCVEEgKDAVPIGRPIANR 3372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 357 dEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRIRPDGNLLVEGRIKEQIN 430
Cdd:PRK12316 3373 -ACYILDGSLEPVPVGALGELYLGGEGLARGYHNRPGLTAERFVPDPFvpgerlYRTGDLARYRADGVIEYIGRVDHQVK 3451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 431 RSGEKISTLEVETLLLQHPDIDDTVVIAVPdellGERICACLPKSINQPD-PAQMQAFLHQKgVQRHKIPDQWLFVAYWP 509
Cdd:PRK12316 3452 IRGFRIELGEIEARLLEHPWVREAVVLAVD----GRQLVAYVVPEDEAGDlREALKAHLKAS-LPEYMVPAHLLFLERMP 3526
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 510 LTAVGKINKRQL--VQMAQAENTETAENNSLmkqyhEHTIA-ITSTPLDLVTHLLADN 564
Cdd:PRK12316 3527 LTPNGKLDRKALprPDAALLQQDYVAPVNEL-----ERRLAaIWADVLKLEQVGLTDN 3579
|
|
| FADD10 |
cd17635 |
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ... |
180-518 |
1.16e-30 |
|
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.
Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 124.30 E-value: 1.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHD-AYTYNFVLSARLCAINTESVYLAVLPVAHNFilGSPGILGTLSQGG-CVLLSDTAS 257
Cdd:cd17635 2 DPLAVIFTSGTTGEPKAVLLANKtFFAVPDILQKEGLNWVVGDVTYLPLPATHIG--GLWWILTCLIHGGlCVTGGENTT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 258 CDEAMPLIEEHKVTHLALVP-ALARLWEQARDWEQSdLSSLRCLQVGGGRltPELAEQVMARLGPLQ---QVFGTAE--G 331
Cdd:cd17635 80 YKSLFKILTTNAVTTTCLVPtLLSKLVSELKSANAT-VPSLRLIGYGGSR--AIAADVRFIEATGLTntaQVYGLSEtgT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 332 LLCYTRLDDPYEviINTQGRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLV 411
Cdd:cd17635 157 ALCLPTDDDSIE--INAVGRPYPGVD-VYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVLI-DGWVNTGDLG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 412 RIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKS-INQPDPAQMQAFLHQ 490
Cdd:cd17635 233 ERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAVVASaELDENAIRALKHTIR 312
|
330 340
....*....|....*....|....*...
gi 2740590833 491 KGVQRHKIPDQWLFVAYWPLTAVGKINK 518
Cdd:cd17635 313 RELEPYARPSTIVIVTDIPRTQSGKVKR 340
|
|
| MACS_like_3 |
cd05971 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
46-523 |
1.29e-30 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 126.01 E-value: 1.29e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhalcqIARPVAYII 125
Cdd:cd05971 5 EKVTFKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGA-------------------IAVPLFALF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 -PDCihgfdyremarevaascpeLEHIIVDGEAEEFIPFASieDEPlniigpgygdiAVLLLSGGTTGTPKLIPRTH--- 201
Cdd:cd05971 66 gPEA-------------------LEYRLSNSGASALVTDGS--DDP-----------ALIIYTSGTTGPPKGALHAHrvl 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 202 --DAYTYNFVLSarlCAINTESVYLAvlPVAHNFILGSPGILGTLSQGGCVLLSDTA---SCDEAMPLIEEHKVTHLALV 276
Cdd:cd05971 114 lgHLPGVQFPFN---LFPRDGDLYWT--PADWAWIGGLLDVLLPSLYFGVPVLAHRMtkfDPKAALDLMSRYGVTTAFLP 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 277 PALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRLDDPYEVIINTQGRPLSE 355
Cdd:cd05971 189 PTALKMMRQQGEQLKHAQVKLRAIATGGESLGEELLGWAREQFGvEVNEFYGQTECNLVIGNCSALFPIKPGSMGKPIPG 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 356 EDeINLADTNLQPVAPSEVGELITRGPYTIT--GYYRAEQHNTVAFTTDgFYRTGDLVRIRPDGNLLVEGRIKEQINRSG 433
Cdd:cd05971 269 HR-VAIVDDNGTPLPPGEVGEIAVELPDPVAflGYWNNPSATEKKMAGD-WLLTGDLGRKDSDGYFWYVGRDDDVITSSG 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 434 EKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSINQPD--PAQMQAFLHQKgVQRHKIPDQWLFVAYWP 509
Cdd:cd05971 347 YRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAfvVLNPGETPSDalAREIQELVKTR-LAAHEYPREIEFVNELP 425
|
490
....*....|....
gi 2740590833 510 LTAVGKINKRQLVQ 523
Cdd:cd05971 426 RTATGKIRRRELRA 439
|
|
| FACL_like_5 |
cd05924 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
179-519 |
1.49e-30 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 124.42 E-value: 1.49e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 179 GDIAVLLLSGGTTGTPK-LIPRTHDAY----------TYNFV---LSARLCAINTESVYLAVLPVAHNFILGSpGILGTL 244
Cdd:cd05924 3 ADDLYILYTGGTTGMPKgVMWRQEDIFrmlmggadfgTGEFTpseDAHKAAAAAAGTVMFPAPPLMHGTGSWT-AFGGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 245 SQGGCVLLSDTASCDEAMPLIEEHKVTHLALV-PALAR-LWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMaRLGP- 321
Cdd:cd05924 82 GGQTVVLPDDRFDPEEVWRTIEKHKVTSMTIVgDAMARpLIDALRDAGPYDLSSLFAISSGGALLSPEVKQGLL-ELVPn 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 322 --LQQVFGTAE---GLLCYTRLDDPyeviiNTQGRPLSEEDEINLA-DTNLQPVAPSEVGELITRGpYTITGYYRAEQHN 395
Cdd:cd05924 161 itLVDAFGSSEtgfTGSGHSAGSGP-----ETGPFTRANPDTVVLDdDGRVVPPGSGGVGWIARRG-HIPLGYYGDEAKT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 396 TVAFTTDGFYR---TGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL 472
Cdd:cd05924 235 AETFPEVDGVRyavPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQEVVAVV 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2740590833 473 P-KSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKR 519
Cdd:cd05924 315 QlREGAGVDLEELREHCRTR-IARYKLPKQVVFVDEIERSPAGKADYR 361
|
|
| MACS_like_4 |
cd05969 |
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ... |
48-521 |
2.54e-30 |
|
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.
Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 125.31 E-value: 2.54e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhalcqIARPV-AYIIP 126
Cdd:cd05969 1 YTFAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGA-------------------VICPLfSAFGP 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 DCIHGFDYREMAReVAASCPELehiivdgeAEEFIPfasiedeplniigpgyGDIAVLLLSGGTTGTPKLIPRTHDAYTY 206
Cdd:cd05969 62 EAIRDRLENSEAK-VLITTEEL--------YERTDP----------------EDPTLLHYTSGTTGTPKGVLHVHDAMIF 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 207 NFVLSARLCAINTESVYlavlpvahnFILGSPGILGTLSQG-------GCVLLSDTASCDEA--MPLIEEHKVTHLALVP 277
Cdd:cd05969 117 YYFTGKYVLDLHPDDIY---------WCTADPGWVTGTVYGiwapwlnGVTNVVYEGRFDAEswYGIIERVKVTVWYTAP 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 278 ALARLWEQARDW--EQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFG---TAEGLLC-YTRLDdpyeVIINTQG 350
Cdd:cd05969 188 TAIRMLMKEGDElaRKYDLSSLRFIHSVGEPLNPEAIRWGMEVFGvPIHDTWWqteTGSIMIAnYPCMP----IKPGSMG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 351 RPLSEEdEINLADTNLQPVAPSEVGELITRG--PYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQ 428
Cdd:cd05969 264 KPLPGV-KAAVVDENGNELPPGTKGILALKPgwPSMFRGIWNDEERYKNSFI-DGWYLTGDLAYRDEDGYFWFVGRADDI 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 429 INRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSINQPDPAQMQAFLH-QKGVQRHKIPDQWLFV 505
Cdd:cd05969 342 IKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAfiSLKEGFEPSDELKEEIINFvRQKLGAHVAPREIEFV 421
|
490
....*....|....*.
gi 2740590833 506 AYWPLTAVGKINKRQL 521
Cdd:cd05969 422 DNLPKTRSGKIMRRVL 437
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
40-523 |
3.00e-30 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 130.46 E-value: 3.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvhalcq 116
Cdd:PRK12316 4569 AVVFDEEKLTYAELNRRANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLdpeYPRER--------- 4639
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 iarpVAYIIPDC------IHGFDYREMAREVAASCPELEHiivDGEAEEFIpfasiEDEPLNIIGPGygDIAVLLLSGGT 190
Cdd:PRK12316 4640 ----LAYMMEDSgaalllTQSHLLQRLPIPDGLASLALDR---DEDWEGFP-----AHDPAVRLHPD--NLAYVIYTSGS 4705
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 191 TGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAhnFILGSPGILGTLSQGGCVLLSDTASCDEA--MPLIEEH 268
Cdd:PRK12316 4706 TGRPKGVAVSHGSLVNHLHATGERYELTPDDRVLQFMSFS--FDGSHEGLYHPLINGASVVIRDDSLWDPErlYAEIHEH 4783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 269 KVTHLALVPA-LARLWEQARdwEQSDLSSLRCLQVGGGRLTPELAEQVMARLGP--LQQVFGTAEG----LLCYTRLDDP 341
Cdd:PRK12316 4784 RVTVLVFPPVyLQQLAEHAE--RDGEPPSLRVYCFGGEAVAQASYDLAWRALKPvyLFNGYGPTETtvtvLLWKARDGDA 4861
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 342 YEVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF-------YRTGDLVRIR 414
Cdd:PRK12316 4862 CGAAYMPIGTPLGNR-SGYVLDGQLNPLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFgapggrlYRTGDLARYR 4940
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 415 PDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQ--KG 492
Cdd:PRK12316 4941 ADGVIDYLGRVDHQVKIRGFRIELGEIEARLREHPAVREAVVIAQEGAVGKQLVGYVVPQDPALADADEAQAELRDelKA 5020
|
490 500 510
....*....|....*....|....*....|....*.
gi 2740590833 493 VQRHKIPD-----QWLFVAYWPLTAVGKINKRQLVQ 523
Cdd:PRK12316 5021 ALRERLPEymvpaHLVFLARMPLTPNGKLDRKALPQ 5056
|
|
| PLN02445 |
PLN02445 |
anthranilate synthase component I |
796-971 |
1.34e-29 |
|
anthranilate synthase component I
Pssm-ID: 215244 [Multi-domain] Cd Length: 523 Bit Score: 124.41 E-value: 1.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 796 INTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAIcERGS-VQHLASRVKG 874
Cdd:PLN02445 313 IVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHIMLVDLGRNDVGKVSKAGSVKVEKLMNI-ERYShVMHISSTVTG 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 875 LLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRS-----------LYQH 943
Cdd:PLN02445 392 ELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELEVTRRGPYSGGFGGVSFTGDMDIALALRTmvfptaarydtMYSY 471
|
170 180 190
....*....|....*....|....*....|....*
gi 2740590833 944 KE----RCW---LQAGAGLVRNSRPEREWQETCEK 971
Cdd:PLN02445 472 KDtnsrREWvahLQAGAGIVADSDPEDEYRECVNK 506
|
|
| PRK07054 |
PRK07054 |
isochorismate synthase; |
699-984 |
3.08e-29 |
|
isochorismate synthase;
Pssm-ID: 235920 [Multi-domain] Cd Length: 475 Bit Score: 122.57 E-value: 3.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 699 TPAFPQTKEVEIINTADTAKNYQDNVANAVKDIASGHYQKVILSRQV--ELGSNIDITHSYWLGRQANTPARSFFLRDGD 776
Cdd:PRK07054 176 APAADDDAPRLLRASALQAREWQHEVRRAVDAIRGGAFGKVVLARDVlqQYARPVAIGPLLRRLRLRDPHAHLFAFRRGN 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 777 FSAYGFSPETVVEAEGsGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICqpETLCVSEF 856
Cdd:PRK07054 256 ACFLGATPERLVRVAA-GDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLS--RALDIPDQ 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 857 MAICERGSVQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALV 936
Cdd:PRK07054 333 PSLHRLPRLQHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIGWLDAHGNGDFAVA 412
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2740590833 937 LRSLYQHKERCWLQAGAGLVRNSRPEREWQETCEKLECIMKYVRPYSA 984
Cdd:PRK07054 413 LRSALITGGACRLFAGCGIVADSEPASEYRETCLKLSGMREALRARDA 460
|
|
| MACS_like_2 |
cd05973 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
48-518 |
4.81e-29 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 121.47 E-value: 4.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhalcqIARPVayiipd 127
Cdd:cd05973 1 LTFGELRALSARFANALQELGVGPGDVVAGLLPRTPELVVTILGIWRLGA-------------------VYQPL------ 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 cIHGFDYREMAREVAASCPELehIIVDGEAEefipfASIEDEPLniigpgygdiaVLLLSGGTTGTPKLIPRThdaytyn 207
Cdd:cd05973 56 -FTAFGPKAIEHRLRTSGARL--VVTDAANR-----HKLDSDPF-----------VMMFTSGTTGLPKGVPVP------- 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 208 fvLSARLCAINTESVYLAVLPVAHNFILGSPG--------ILGTLSQG-GCVLLSDTASCDEAMPLIEEHKVTHLALVPA 278
Cdd:cd05973 110 --LRALAAFGAYLRDAVDLRPEDSFWNAADPGwayglyyaITGPLALGhPTILLEGGFSVESTWRVIERLGVTNLAGSPT 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 279 LARLWEQARDWEQSDLS-SLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE-GLLCYTRLDDPYEVIINTQGRPLSE 355
Cdd:cd05973 188 AYRLLMAAGAEVPARPKgRLRRVSSAGEPLTPEVIRWFDAALGvPIHDHYGQTElGMVLANHHALEHPVHAGSAGRAMPG 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 356 EdEINLADTNLQPVAPSEVGEL---ITRGP-YTITGYYRAEQHNTVAfttdGFYRTGDLVRIRPDGNLLVEGRIKEQINR 431
Cdd:cd05973 268 W-RVAVLDDDGDELGPGEPGRLaidIANSPlMWFRGYQLPDTPAIDG----GYYLTGDTVEFDPDGSFSFIGRADDVITM 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 432 SGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSIN-QPDPA---QMQAFLHQKgVQRHKIPDQWLFVAY 507
Cdd:cd05973 343 SGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVLRGGhEGTPAladELQLHVKKR-LSAHAYPRTIHFVDE 421
|
490
....*....|.
gi 2740590833 508 WPLTAVGKINK 518
Cdd:cd05973 422 LPKTPSGKIQR 432
|
|
| PRK12406 |
PRK12406 |
long-chain-fatty-acid--CoA ligase; Provisional |
40-521 |
2.26e-28 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 120.57 E-value: 2.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLmptqrahDVHAlcqIAR 119
Cdd:PRK12406 4 TIISGDRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPV-------NWHF---KPE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 120 PVAYIIPDC------IHGFDYREMAREVAASCPELE-----------------------HIIVDGEAEEFIPFAsiedep 170
Cdd:PRK12406 74 EIAYILEDSgarvliAHADLLHGLASALPAGVTVLSvptppeiaaayrispalltppagAIDWEGWLAQQEPYD------ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 171 lniiGPGYGDIAVLLLSGGTTGTPKLIPRthDAYTYNFVLS-----ARLCAINTESVYLAVLPVAHNfilgSPGILGTLS 245
Cdd:PRK12406 148 ----GPPVPQPQSMIYTSGTTGHPKGVRR--AAPTPEQAAAaeqmrALIYGLKPGIRALLTGPLYHS----APNAYGLRA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 246 Q--GGCVLLSDTASCDEAMPLIEEHKVTHLALVPA----LARLWEQARdwEQSDLSSLRCLQVGGGRLTPELAEQVMARL 319
Cdd:PRK12406 218 GrlGGVLVLQPRFDPEELLQLIERHRITHMHMVPTmfirLLKLPEEVR--AKYDVSSLRHVIHAAAPCPADVKRAMIEWW 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 320 GPLQQVF--GTAEGLLCYTRLDD----PyeviiNTQGRPlSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQ 393
Cdd:PRK12406 296 GPVIYEYygSTESGAVTFATSEDalshP-----GTVGKA-APGAELRFVDEDGRPLPQGEIGEIYSRIAGNPDFTYHNKP 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 394 HNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL- 472
Cdd:PRK12406 370 EKRAEIDRGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEALMAVVe 449
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 2740590833 473 PKSINQPDPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK12406 450 PQPGATLDEADIRAQL-KARLAGYKVPKHIEIMAELPREDSGKIFKRRL 497
|
|
| LC_FACL_like |
cd05914 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ... |
41-461 |
2.29e-28 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 119.85 E-value: 2.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 41 LIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHalcqiarp 120
Cdd:cd05914 1 LYYGGEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVH-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 121 vayiipdcihgfdyremarevaascpeleHIIVDGEAEefIPFASIEDeplniigpgygDIAVLLLSGGTTGTPKLIPRT 200
Cdd:cd05914 73 -----------------------------HILNHSEAK--AIFVSDED-----------DVALINYTSGTTGNSKGVMLT 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 201 HDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDTAScdeamPLIE---EHKVTHLALVP 277
Cdd:cd05914 111 YRNIVSNVDGVKEVVLLGKGDKILSILPLHHIYPLTFTLLLPLLNGAHVVFLDKIPS-----AKIIalaFAQVTPTLGVP 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 278 ALARLWEQARDWEQSDLSSLRCLQ-------------------------------VGGGRLTPELaEQVMARLG-PLQQV 325
Cdd:cd05914 186 VPLVIEKIFKMDIIPKLTLKKFKFklakkinnrkirklafkkvheafggnikefvIGGAKINPDV-EEFLRTIGfPYTIG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 326 FGTAEG--LLCYTRlddPYEVIINTQGRPLSEEdEINLADtnlqPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDG 403
Cdd:cd05914 265 YGMTETapIISYSP---PNRIRLGSAGKVIDGV-EVRIDS----PDPATGEGEIIVRGPNVMKGYYKNPEATAEAFDKDG 336
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 404 FYRTGDLVRIRPDGNLLVEGRIKEQI-NRSGEKISTLEVETLLLQHPDI---------DDTVVIAVPD 461
Cdd:cd05914 337 WFHTGDLGKIDAEGYLYIRGRKKEMIvLSSGKNIYPEEIEAKINNMPFVleslvvvqeKKLVALAYID 404
|
|
| ACS |
cd05966 |
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ... |
15-529 |
3.17e-28 |
|
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.
Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 121.13 E-value: 3.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 15 PNYLW--NGKT------LDQQLAGWssiwGNKTALIYH------EQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLP 80
Cdd:cd05966 42 PFIKWfeGGKLnisyncLDRHLKER----GDKVAIIWEgdepdqSRTITYRELLREVCRFANVLKSLGVKKGDRVAIYMP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 81 NRISFVVTCFALFRLGA-HPVL--------LMptQRAHDvhalcqiARPVAYIIPDcihGFdYR--------EMAREVAA 143
Cdd:cd05966 118 MIPELVIAMLACARIGAvHSVVfagfsaesLA--DRIND-------AQCKLVITAD---GG-YRggkviplkEIVDEALE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 144 SCPELEHIIVDGEAEEFIPFASIEDEPLNIIGPGYG-----------DIAVLLLSGGTTGTPKLIPRTHDAY------TY 206
Cdd:cd05966 185 KCPSVEKVLVVKRTGGEVPMTEGRDLWWHDLMAKQSpecepewmdseDPLFILYTSGSTGKPKGVVHTTGGYllyaatTF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 207 NFVLSARlcainTESVYLAVLPVA----HNFILGSPGILGTLSqggcVLLsdtascdEAMP----------LIEEHKVTH 272
Cdd:cd05966 265 KYVFDYH-----PDDIYWCTADIGwitgHSYIVYGPLANGATT----VMF-------EGTPtypdpgrywdIVEKHKVTI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVPALAR-LWEQARDW-EQSDLSSLRCL-----------------QVGGGRL----TPELAEQVMARLGPLQQVFGTA 329
Cdd:cd05966 329 FYTAPTAIRaLMKFGDEWvKKHDLSSLRVLgsvgepinpeawmwyyeVIGKERCpivdTWWQTETGGIMITPLPGATPLK 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 330 EGllCYTRlddPYEVIintqgrplseedEINLADTNLQPVAPSEVGELITRGPY-----TITG-YYRAEQHNTVAFTtdG 403
Cdd:cd05966 409 PG--SATR---PFFGI------------EPAILDEEGNEVEGEVEGYLVIKRPWpgmarTIYGdHERYEDTYFSKFP--G 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 404 FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA-CLPKSINQPDPA 482
Cdd:cd05966 470 YYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEAIYAfVTLKDGEEPSDE 549
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 483 QMQAFLHQkgVqRHKI-----PDQWLFVAYWPLTAVGKINKRQLVQMAQAEN 529
Cdd:cd05966 550 LRKELRKH--V-RKEIgpiatPDKIQFVPGLPKTRSGKIMRRILRKIAAGEE 598
|
|
| PRK07867 |
PRK07867 |
acyl-CoA synthetase; Validated |
40-533 |
9.81e-28 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 119.02 E-value: 9.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIR-RGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQR----AHDV-HA 113
Cdd:PRK07867 21 GLYFEDSFTSWREHIRGSAARAAALRARLDPtRPPHVGVLLDNTPEFSLLLGAAALSGIVPVGLNPTRRgaalARDIaHA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 LCQIArpvayiipdcIHGFDYREMAREVAascPELEHIIVDGE--AEEFIPFAsieDEPLNIIGPGYGDIAVLLLSGGTT 191
Cdd:PRK07867 101 DCQLV----------LTESAHAELLDGLD---PGVRVINVDSPawADELAAHR---DAEPPFRVADPDDLFMLIFTSGTS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 192 GTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAH-NFILG--SPGilgtLSQGGCVLLSDTASCDEAMPLIEEH 268
Cdd:PRK07867 165 GDPKAVRCTHRKVASAGVMLAQRFGLGPDDVCYVSMPLFHsNAVMAgwAVA----LAAGASIALRRKFSASGFLPDVRRY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 269 KVTHLALV-PALARLW---EQARDWEqsdlSSLRclQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRLDDPYE 343
Cdd:PRK07867 241 GATYANYVgKPLSYVLatpERPDDAD----NPLR--IVYGNEGAPGDIARFARRFGcVVVDGFGSTEGGVAITRTPDTPP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 344 VIINtqgrPLSEEDEINLADTnLQPVAPSE------------VGELI-TRGPYTITGYYRAEQhNTVAFTTDGFYRTGDL 410
Cdd:PRK07867 315 GALG----PLPPGVAIVDPDT-GTECPPAEdadgrllnadeaIGELVnTAGPGGFEGYYNDPE-ADAERMRGGVYWSGDL 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 411 VRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLH 489
Cdd:PRK07867 389 AYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVGDQVMAALvLAPGAKFDPDAFAEFLA 468
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 2740590833 490 QkgvQRHKIPDQW----LFVAYWPLTAVGKINKRQLVqmaqAENTETA 533
Cdd:PRK07867 469 A---QPDLGPKQWpsyvRVCAELPRTATFKVLKRQLS----AEGVDCA 509
|
|
| PtmA |
cd17636 |
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ... |
191-470 |
1.19e-26 |
|
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 112.01 E-value: 1.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 191 TGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGspGILGTLSQGGCVLLSDTASCDEAMPLIEEHKV 270
Cdd:cd17636 12 SGRPNGALLSHQALLAQALVLAVLQAIDEGTVFLNSGPLFHIGTLM--FTLATFHAGGTNVFVRRVDAEEVLELIEAERC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 271 THLALVPALARLWEQARDWEQSDLSSLRclqvgGGRLTPELAEQVMARLGPLQQV---FGTAE--GLLCYTRLDDPyevI 345
Cdd:cd17636 90 THAFLLPPTIDQIVELNADGLYDLSSLR-----SSPAAPEWNDMATVDTSPWGRKpggYGQTEvmGLATFAALGGG---A 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 346 INTQGRPlSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTvAFTTDGFYRTGDLVRIRPDGNLLVEGRi 425
Cdd:cd17636 162 IGGAGRP-SPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNA-RRTRGGWHHTNDLGRREPDGSLSFVGP- 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2740590833 426 KEQINRSG-EKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA 470
Cdd:cd17636 239 KTRMIKSGaENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKA 284
|
|
| PRK06923 |
PRK06923 |
isochorismate synthase DhbC; Validated |
718-977 |
2.58e-26 |
|
isochorismate synthase DhbC; Validated
Pssm-ID: 235886 [Multi-domain] Cd Length: 399 Bit Score: 112.52 E-value: 2.58e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 718 KNYQDNVANAVKDIASGHYQKVILSRQVELGSNIDI-------------THSYW----LGRQANTPARSFFlrdgdfsay 780
Cdd:PRK06923 122 EVYMNGVKQGIAKIQDGDLKKIVLSRSLDVKSSEKIdkqkllrelaehnKHGYTfavnLPKDENENSKTLI--------- 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 781 GFSPETVVEAEGSGWInTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQpeTLCVSEFMAIC 860
Cdd:PRK06923 193 GASPELLVSRHGMQVI-SNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVEAVAAALRPYCH--TLHVPEKPSVI 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 861 ERGSVQHLASRVKG-LLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRS 939
Cdd:PRK06923 270 HTEAMWHLSTEVKGeLKDPNTSSLELAIALHPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGEWIVTIRC 349
|
250 260 270
....*....|....*....|....*....|....*...
gi 2740590833 940 LYQHKERCWLQAGAGLVRNSRPEREWQETCEKLECIMK 977
Cdd:PRK06923 350 AEVEENTLRLYAGAGVVAESKPEDELAETSAKFQTMLK 387
|
|
| PRK08279 |
PRK08279 |
long-chain-acyl-CoA synthetase; Validated |
21-461 |
3.60e-26 |
|
long-chain-acyl-CoA synthetase; Validated
Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 114.59 E-value: 3.60e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 21 GKTLDQqlagWSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhPV 100
Cdd:PRK08279 40 GDVFEE----AAARHPDRPALLFEDQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRPEYLAAWLGLAKLGA-VV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 101 LLMPTQRAHDV--HALcQIARPVAYII-PDCIHGFDyremarEVAASCPELEHIIVDGEAEEFIPFASIEdepLNIIGPG 177
Cdd:PRK08279 115 ALLNTQQRGAVlaHSL-NLVDAKHLIVgEELVEAFE------EARADLARPPRLWVAGGDTLDDPEGYED---LAAAAAG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 178 Y-------------GDIAVLLLSGGTTGTPKLIPRTHdaytYNFVLSAR----LCAINTESVYLAVLPVAHN----FILG 236
Cdd:PRK08279 185 ApttnpasrsgvtaKDTAFYIYTSGTTGLPKAAVMSH----MRWLKAMGgfggLLRLTPDDVLYCCLPLYHNtggtVAWS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 237 SpgilgTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALAR-LWEQARDWEQSDlSSLRCLqVGGGrLTPELAEQV 315
Cdd:PRK08279 261 S-----VLAAGATLALRRKFSASRFWDDVRRYRATAFQYIGELCRyLLNQPPKPTDRD-HRLRLM-IGNG-LRPDIWDEF 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 316 MARLGpLQQVF---GTAEGLLCYTRLDDpyevIINTQGR-PLSE-------------EDEINLADTNLQPVAPSEVGELI 378
Cdd:PRK08279 333 QQRFG-IPRILefyAASEGNVGFINVFN----FDGTVGRvPLWLahpyaivkydvdtGEPVRDADGRCIKVKPGEVGLLI 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 379 T----RGPYtiTGYYRAEQHNTV----AFTT-DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHP 449
Cdd:PRK08279 408 GritdRGPF--DGYTDPEASEKKilrdVFKKgDAWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENVATTEVENALSGFP 485
|
490
....*....|....
gi 2740590833 450 DIDDTVV--IAVPD 461
Cdd:PRK08279 486 GVEEAVVygVEVPG 499
|
|
| PRK07008 |
PRK07008 |
long-chain-fatty-acid--CoA ligase; Validated |
47-524 |
4.93e-26 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 113.65 E-value: 4.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA--HPV--LLMPTQrahdvhalcqiarpVA 122
Cdd:PRK07008 39 RYTYRDCERRAKQLAQALAALGVEPGDRVGTLAWNGYRHLEAYYGVSGSGAvcHTInpRLFPEQ--------------IA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 123 YII---PDCIHGFD--YREMAREVAASCPELEHIIVDGEAEEF----IPFASIEDeplnIIGPGYGDIA----------V 183
Cdd:PRK07008 105 YIVnhaEDRYVLFDltFLPLVDALAPQCPNVKGWVAMTDAAHLpagsTPLLCYET----LVGAQDGDYDwprfdenqasS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 184 LLLSGGTTGTPKLIPRTHDA---YTYNFVLSARLCAinteSVYLAVLPVAHNFILGSPGILGTLSQGGCVLL-----SDT 255
Cdd:PRK07008 181 LCYTSGTTGNPKGALYSHRStvlHAYGAALPDAMGL----SARDAVLPVVPMFHVNAWGLPYSAPLTGAKLVlpgpdLDG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 256 ASCDEampLIEEHKVTHLALVPALarlWEQARDWEQSD---LSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE- 330
Cdd:PRK07008 257 KSLYE---LIEAERVTFSAGVPTV---WLGLLNHMREAglrFSTLRRTVIGGSACPPAMIRTFEDEYGvEVIHAWGMTEm 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 331 ---GLLC---YTRLDDPYEV---IINTQGRPLSEED-EINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVaft 400
Cdd:PRK07008 331 splGTLCklkWKHSQLPLDEqrkLLEKQGRVIYGVDmKIVGDDGRELPWDGKAFGDLQVRGPWVIDRYFRGDASPLV--- 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 401 tDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGER-ICACLPKSINQP 479
Cdd:PRK07008 408 -DGWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERpLLVVVKRPGAEV 486
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 2740590833 480 DPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQM 524
Cdd:PRK07008 487 TREELLAFYEGK-VAKWWIPDDVVFVDAIPHTATGKLQKLKLREQ 530
|
|
| A_NRPS_ProA |
cd17656 |
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ... |
37-521 |
4.95e-26 |
|
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 112.95 E-value: 4.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL---MPTQRahdvha 113
Cdd:cd17656 3 DAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIdpeYPEER------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 lcqiarpVAYIIPDCihGFDYREMAREVAASCP---ELEHIIVDGEAEEfipfasiEDEPLNIIGPGyGDIAVLLLSGGT 190
Cdd:cd17656 77 -------RIYIMLDS--GVRVVLTQRHLKSKLSfnkSTILLEDPSISQE-------DTSNIDYINNS-DDLLYIIYTSGT 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 191 TGTPKLIPRTHD------AYTYNFVLsarlcaINTESVYLAVlpVAHNFILGSPGILGTLSQGGCVLLSDTAS---CDEA 261
Cdd:cd17656 140 TGKPKGVQLEHKnmvnllHFEREKTN------INFSDKVLQF--ATCSFDVCYQEIFSTLLSGGTLYIIREETkrdVEQL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 262 MPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRL--TPELAEQVMARLGPLQQVFGTAEGLLCYTRLD 339
Cdd:cd17656 212 FDLVKRHNIEVVFLPVAFLKFIFSEREFINRFPTCVKHIITAGEQLviTNEFKEMLHEHNVHLHNHYGPSETHVVTTYTI 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 340 DPYEVI--INTQGRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLV 411
Cdd:cd17656 292 NPEAEIpeLPPIGKPISNTW-IYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTAEKFFPDPFdpnermYRTGDLA 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 412 RIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSINQpdpAQMQAFLh 489
Cdd:cd17656 371 RYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSEAVVLDKADDKGEKYLCAyfVMEQELNI---SQLREYL- 446
|
490 500 510
....*....|....*....|....*....|..
gi 2740590833 490 QKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17656 447 AKQLPEYMIPSFFVPLDQLPLTPNGKVDRKAL 478
|
|
| PRK09274 |
PRK09274 |
peptide synthase; Provisional |
35-460 |
1.05e-25 |
|
peptide synthase; Provisional
Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 112.68 E-value: 1.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALIYheQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPtqrAHDVHAL 114
Cdd:PRK09274 31 RGADGKLAY--DELSFAELDARSDAIAHGLNAAGIGRGMRAVLMVTPSLEFFALTFALFKAGAVPVLVDP---GMGIKNL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 CQI---ARPVAYI-IPD-----CIHGFDYREMAREVAAS------CPELEHIIVDGEAEEFIPFASIEDEPlniigpgyg 179
Cdd:PRK09274 106 KQClaeAQPDAFIgIPKahlarRLFGWGKPSVRRLVTVGgrllwgGTTLATLLRDGAAAPFPMADLAPDDM--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 diAVLLLSGGTTGTPKLIPRTHDaytyNFVlsARLCAINTE------SVYLAVLPVahnFILGSPGiLGtlsqGGCVL-- 251
Cdd:PRK09274 177 --AAILFTSGSTGTPKGVVYTHG----MFE--AQIEALREDygiepgEIDLPTFPL---FALFGPA-LG----MTSVIpd 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 252 --LSDTASCDEAMPL--IEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVF- 326
Cdd:PRK09274 241 mdPTRPATVDPAKLFaaIERYGVTNLFGSPALLERLGRYGEANGIKLPSLRRVISAGAPVPIAVIERFRAMLPPDAEILt 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 327 --GTAEGL-----------------------LCYTRLDDPYEV-IINTQGRPLSEEDEInladtnlQPVAPSEVGELITR 380
Cdd:PRK09274 321 pyGATEALpissiesreilfatraatdngagICVGRPVDGVEVrIIAISDAPIPEWDDA-------LRLATGEIGEIVVA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 381 GPYTITGYYRAEQHNTVAFTTDG----FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVV 456
Cdd:PRK09274 394 GPMVTRSYYNRPEATRLAKIPDGqgdvWHRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGVKRSAL 473
|
....
gi 2740590833 457 IAVP 460
Cdd:PRK09274 474 VGVG 477
|
|
| PRK13564 |
PRK13564 |
anthranilate synthase component 1; |
770-968 |
1.07e-25 |
|
anthranilate synthase component 1;
Pssm-ID: 237428 [Multi-domain] Cd Length: 520 Bit Score: 112.62 E-value: 1.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 770 FFLRDGDFSAYGFSPETVV--EAEgSGWINTQPLAGTR--------ALTHDkkQDQQLRADLLSDPKEISEHAVSVKLAL 839
Cdd:PRK13564 294 FYMQDEDFTLFGASPESALkyDAS-SRQVEIYPIAGTRprgrradgSIDRD--LDSRIELELRTDHKELAEHLMLVDLAR 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 840 EELAPICQPETLCVSEFMAIcERGS-VQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLY 918
Cdd:PRK13564 371 NDLARICQPGSRYVADLLKV-DRYShVMHLVSRVVGELRHDLDALHAYRACMNMGTLTGAPKVRAMQLIREVEGQRRGSY 449
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2740590833 919 SGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAGAGLVRNSRPEREWQET 968
Cdd:PRK13564 450 GGAVGYLTGHGDLDTCIVIRSAFVENGIATVQAGAGVVLDSDPQSEADET 499
|
|
| LC_FACS_like |
cd17640 |
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ... |
45-503 |
1.12e-25 |
|
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 111.68 E-value: 1.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 45 EQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhalcqiarpvayi 124
Cdd:cd17640 3 PKRITYKDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGA--------------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 125 iPDCIHGFDyremarevaASCPELEHIIVDGEAEEFIpfasIEDEPlniigpgyGDIAVLLLSGGTTGTPKLIPRTHDAY 204
Cdd:cd17640 56 -VDVVRGSD---------SSVEELLYILNHSESVALV----VENDS--------DDLATIIYTSGTTGNPKGVMLTHANL 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 205 TYNFVlsaRLCAINTESV---YLAVLPVAHNFILGSPGILgtLSQGGCVLLSDTASCDEAMPLIEEHkvtHLALVPalaR 281
Cdd:cd17640 114 LHQIR---SLSDIVPPQPgdrFLSILPIWHSYERSAEYFI--FACGCSQAYTSIRTLKDDLKRVKPH---YIVSVP---R 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 282 LWEQARDWEQSDLSS-----------------LRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAE--GLLCYTRLDdpy 342
Cdd:cd17640 183 LWESLYSGIQKQVSKsspikqflflfflsggiFKFGISGGGALPPHVDTFFEAIGIEVLNGYGLTEtsPVVSARRLK--- 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 343 EVIINTQGRPLSEEdEINLADTNLQ-PVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLV 421
Cdd:cd17640 260 CNVRGSVGRPLPGT-EIKIVDPEGNvVLPPGEKGIVWVRGPQVMKGYYKNPEATSKVLDSDGWFNTGDLGWLTCGGELVL 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 422 EGRIKEQINRS-GEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICaclpksinqPDPAQMQAFLHQKGVQRHKIPD 500
Cdd:cd17640 339 TGRAKDTIVLSnGENVEPQPIEEALMRSPFIEQIMVVGQDQKRLGALIV---------PNFEELEKWAKESGVKLANDRS 409
|
...
gi 2740590833 501 QWL 503
Cdd:cd17640 410 QLL 412
|
|
| PLN03102 |
PLN03102 |
acyl-activating enzyme; Provisional |
32-554 |
1.49e-25 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 112.81 E-value: 1.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 32 SSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvLLMPTQRAHDV 111
Cdd:PLN03102 24 SECYPNRTSIIYGKTRFTWPQTYDRCCRLAASLISLNITKNDVVSVLAPNTPAMYEMHFAVPMAGA---VLNPINTRLDA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 112 HALCQIARPVAYIIPDCIHGFDyrEMAREVAA------SCPELEHIIVDGEAEEFIPFASIED--------EPLNIIGPG 177
Cdd:PLN03102 101 TSIAAILRHAKPKILFVDRSFE--PLAREVLHllssedSNLNLPVIFIHEIDFPKRPSSEELDyecliqrgEPTPSLVAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 178 Y------GDIAVLLLSGGTTGTPKLIPRTHDAyTYNFVLSARL-CAINTESVYLAVLPVAHnfILGSPGILGTLSQGGCV 250
Cdd:PLN03102 179 MfriqdeHDPISLNYTSGTTADPKGVVISHRG-AYLSTLSAIIgWEMGTCPVYLWTLPMFH--CNGWTFTWGTAARGGTS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 LLSDTASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVmARLG-PLQQVFGTA 329
Cdd:PLN03102 256 VCMRHVTAPEIYKNIEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGPVHVLTGGSPPPAALVKKV-QRLGfQVMHAYGLT 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 330 EG----LLC-----YTRLDDPYEVIINT-QGRPLSEEDEINLADTNLQPVAPSE---VGELITRGPYTITGYYRAEQHNT 396
Cdd:PLN03102 335 EAtgpvLFCewqdeWNRLPENQQMELKArQGVSILGLADVDVKNKETQESVPRDgktMGEIVIKGSSIMKGYLKNPKATS 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 397 VAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPK 474
Cdd:PLN03102 415 EAFK-HGWLNTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAfvVLEK 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 475 SINQPDPAQMQAFLHQKGVQRH--------KIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENTEtaENNSLMKQYHEHT 546
Cdd:PLN03102 494 GETTKEDRVDKLVTRERDLIEYcrenlphfMCPRKVVFLQELPKNGNGKILKPKLRDIAKGLVVE--DEDNVIKKVHQRP 571
|
....*...
gi 2740590833 547 IAITSTPL 554
Cdd:PLN03102 572 VEHFSSRL 579
|
|
| PRK06018 |
PRK06018 |
putative acyl-CoA synthetase; Provisional |
47-521 |
1.84e-25 |
|
putative acyl-CoA synthetase; Provisional
Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 112.15 E-value: 1.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA--HPV--LLMPTQrahdvhalcqiarpVA 122
Cdd:PRK06018 39 RTTYAQIHDRALKVSQALDRDGIKLGDRVATIAWNTWRHLEAWYGIMGIGAicHTVnpRLFPEQ--------------IA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 123 YII---PDCIHGFD--YREMAREVAASCPELEHIIVDGEAEEF----IPFASIEDEplnIIGPGYGDI----------AV 183
Cdd:PRK06018 105 WIInhaEDRVVITDltFVPILEKIADKLPSVERYVVLTDAAHMpqttLKNAVAYEE---WIAEADGDFawktfdentaAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 184 LLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTES--VYLAVLPVAHNFILG----SPGILGTLSQGGCVLlsDTAS 257
Cdd:PRK06018 182 MCYTSGTTGDPKGVLYSHRSNVLHALMANNGDALGTSAadTMLPVVPLFHANSWGiafsAPSMGTKLVMPGAKL--DGAS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 258 CDEampLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLqVGGGRLTPELAEQV----------------MARLGP 321
Cdd:PRK06018 260 VYE---LLDTEKVTFTAGVPTVWLMLLQYMEKEGLKLPHLKMV-VCGGSAMPRSMIKAfedmgvevrhawgmteMSPLGT 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 322 LQQVFGTAEGLLCYTRLDdpyevIINTQGR-PLSEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHntvAFT 400
Cdd:PRK06018 336 LAALKPPFSKLPGDARLD-----VLQKQGYpPFGVEMKITDDAGKELPWDGKTFGRLKVRGPAVAAAYYRVDGE---ILD 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 401 TDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGER-ICACLPKSINQP 479
Cdd:PRK06018 408 DDGFFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYHPKWDERpLLIVQLKPGETA 487
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2740590833 480 DPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK06018 488 TREEILKYMDGK-IAKWWMPDDVAFVDAIPHTATGKILKTAL 528
|
|
| PRK13388 |
PRK13388 |
acyl-CoA synthetase; Provisional |
39-525 |
2.77e-25 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 111.27 E-value: 2.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHE-LHQSAERlANGLyhRGIRRGD---HVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQR----AHD 110
Cdd:PRK13388 18 IAVRYGDRTWTWREvLAEAAAR-AAAL--IALADPDrplHVGVLLGNTPEMLFWLAAAALGGYVLVGLNTTRRgaalAAD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 111 V-HALCQIarpvayIIPDCIHgfdyreMAREVAASCPELEHIIVDGEA-EEFIPFASiEDEPLNIIGPGygDIAVLLLSG 188
Cdd:PRK13388 95 IrRADCQL------LVTDAEH------RPLLDGLDLPGVRVLDVDTPAyAELVAAAG-ALTPHREVDAM--DPFMLIFTS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 189 GTTGTPKLIPRTHDAYTY-NFVLSARLCAINTESVYLAvLPVAH-NFILGspGILGTLSQGGCVLLSDTASCDEAMPLIE 266
Cdd:PRK13388 160 GTTGAPKAVRCSHGRLAFaGRALTERFGLTRDDVCYVS-MPLFHsNAVMA--GWAPAVASGAAVALPAKFSASGFLDDVR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 267 EHKVTHLALV-PALARLW---EQARDWEQSdlsslrcLQVG-GGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTRLDD 340
Cdd:PRK13388 237 RYGATYFNYVgKPLAYILatpERPDDADNP-------LRVAfGNEASPRDIAEFSRRFGcQVEDGYGSSEGAVIVVREPG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 --------PYE--VIINTQGR---PLSEEDEiNLADTNlqpvaPSE-VGELI-TRGPYTITGYYRAEQHNTVAFTtDGFY 405
Cdd:PRK13388 310 tppgsigrGAPgvAIYNPETLtecAVARFDA-HGALLN-----ADEaIGELVnTAGAGFFEGYYNNPEATAERMR-HGMY 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 406 RTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERI-CACLPKSINQPDPAQM 484
Cdd:PRK13388 383 WSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPDERVGDQVmAALVLRDGATFDPDAF 462
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2740590833 485 QAFLH-QKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMA 525
Cdd:PRK13388 463 AAFLAaQPDLGTKAWPRYVRIAADLPSTATNKVLKRELIAQG 504
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
40-541 |
3.24e-25 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 113.72 E-value: 3.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIAR 119
Cdd:PRK05691 2206 ALTFAGQTLSYAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKAGGAYVPLDPEYPLERLHYMIEDSG 2285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 120 pVAYIIPDCIHGFDYREMAREVAASCPELEHIIVDGEAEefipfasieDEPLNIIGPGYgdIAVLLLSGGTTGTPKLIPR 199
Cdd:PRK05691 2286 -IGLLLSDRALFEALGELPAGVARWCLEDDAAALAAYSD---------APLPFLSLPQH--QAYLIYTSGSTGKPKGVVV 2353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 TH-------DAYTYNFVLSARLCAINTESVylavlpvahNFILGSPGILGTLSQGGCVLLSDTASCD--EAMPLIEEHKV 270
Cdd:PRK05691 2354 SHgeiamhcQAVIERFGMRADDCELHFYSI---------NFDAASERLLVPLLCGARVVLRAQGQWGaeEICQLIREQQV 2424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 271 THLALVPALArlwEQARDW--EQSDLSSLRCLQVGGGRLTPELAEQVMARLGPlqQVFGTAEGllcytrlddPYEVIINT 348
Cdd:PRK05691 2425 SILGFTPSYG---SQLAQWlaGQGEQLPVRMCITGGEALTGEHLQRIRQAFAP--QLFFNAYG---------PTETVVMP 2490
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 349 QGRPLSEEDEINLA----------------DTNLQPVAPSEVGELITRGPYTITGYYR-----AEQHNTVAFTTDG--FY 405
Cdd:PRK05691 2491 LACLAPEQLEEGAAsvpigrvvgarvayilDADLALVPQGATGELYVGGAGLAQGYHDrpgltAERFVADPFAADGgrLY 2570
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 406 RTGDLVRIRPDGnlLVE--GRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVpDELLGERICACLPKSINQPDPAQ 483
Cdd:PRK05691 2571 RTGDLVRLRADG--LVEyvGRIDHQVKIRGFRIELGEIESRLLEHPAVREAVVLAL-DTPSGKQLAGYLVSAVAGQDDEA 2647
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2740590833 484 mQAFLHQ--KGVQRHKIPD-----QWLFVAYWPLTAVGKINKRQLVQMAQAENTE--TAENNSLMKQ 541
Cdd:PRK05691 2648 -QAALREalKAHLKQQLPDymvpaHLILLDSLPLTANGKLDRRALPAPDPELNRQayQAPRSELEQQ 2713
|
|
| FAAL |
cd05931 |
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ... |
44-462 |
6.21e-25 |
|
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.
Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 110.41 E-value: 6.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 44 HEQRLTYHELHQSAERLANGLYHRGiRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQI---ARP 120
Cdd:cd05931 21 REETLTYAELDRRARAIAARLQAVG-KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLPPPTPGRHAERLAAIladAGP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 121 VAYIIPDcihgfDYREMAREVAASCPELEHIIVdgEAEEFIPFASIEDEPLNIIGPgyGDIAVLLLSGGTTGTPKLIPRT 200
Cdd:cd05931 100 RVVLTTA-----AALAAVRAFAASRPAAGTPRL--LVVDLLPDTSAADWPPPSPDP--DDIAYLQYTSGSTGTPKGVVVT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 201 HDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSpGILGTLSQGG-CVLLSdtascdeamP------------LIEE 267
Cdd:cd05931 171 HRNLLANVRQIRRAYGLDPGDVVVSWLPLYHDMGLIG-GLLTPLYSGGpSVLMS---------PaaflrrplrwlrLISR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 268 HKVTHLAlVP----ALARLWEQARDWEQSDLSSLRCLQVGGGRLTPE------------------------LAEQV---- 315
Cdd:cd05931 241 YRATISA-APnfayDLCVRRVRDEDLEGLDLSSWRVALNGAEPVRPAtlrrfaeafapfgfrpeafrpsygLAEATlfvs 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 316 MARLG-PLQQVFGTAEGLLCYTRLDDPYEVIINTQ---GRPLSEEdEINLADTN-LQPVAPSEVGELITRGPYTITGYYR 390
Cdd:cd05931 320 GGPPGtGPVVLRVDRDALAGRAVAVAADDPAARELvscGRPLPDQ-EVRIVDPEtGRELPDGEVGEIWVRGPSVASGYWG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 391 AEQHNTVAFTT------DGFYRTGDLVRIRpDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPD---IDDTVVIAVPD 461
Cdd:cd05931 399 RPEATAETFGAlaatdeGGWLRTGDLGFLH-DGELYITGRLKDLIIVRGRNHYPQDIEATAEEAHPalrPGCVAAFSVPD 477
|
.
gi 2740590833 462 E 462
Cdd:cd05931 478 D 478
|
|
| PRK05677 |
PRK05677 |
long-chain-fatty-acid--CoA ligase; Validated |
48-521 |
6.46e-25 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 110.62 E-value: 6.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGL-YHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMP--TQR----------AHDVHAL 114
Cdd:PRK05677 50 LTYGELYKLSGAFAAWLqQHTDLKPGDRIAVQLPNVLQYPVAVFGAMRAGLIVVNTNPlyTARemehqfndsgAKALVCL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 CQIARPVAYIIPdciHGFDYREMAREVAASCPELEHIIVDG---EAEEFIPFASIED-------------EPLNIIGPGY 178
Cdd:PRK05677 130 ANMAHLAEKVLP---KTGVKHVIVTEVADMLPPLKRLLINAvvkHVKKMVPAYHLPQavkfndalakgagQPVTEANPQA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 179 GDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTE---SVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDT 255
Cdd:PRK05677 207 DDVAVLQYTGGTTGVAKGAMLTHRNLVANMLQCRALMGSNLNegcEILIAPLPLYHIYAFTFHCMAMMLIGNHNILISNP 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 256 ASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLC 334
Cdd:PRK05677 287 RDLPAMVKELGKWKFSGFVGLNTLFVALCNNEAFRKLDFSALKLTLSGGMALQLATAERWKEVTGcAICEGYGMTETSPV 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 YTRldDPYEVI-INTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRI 413
Cdd:PRK05677 367 VSV--NPSQAIqVGTIGIPVPST-LCKVIDDDGNELPLGEVGELCVKGPQVMKGYWQRPEATDEILDSDGWLKTGDIALI 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERI-CACLPKSINQPDPAQMQAFLHQKg 492
Cdd:PRK05677 444 QEDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQCAAIGVPDEKSGEAIkVFVVVKPGETLTKEQVMEHMRAN- 522
|
490 500
....*....|....*....|....*....
gi 2740590833 493 VQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK05677 523 LTGYKVPKAVEFRDELPTTNVGKILRREL 551
|
|
| A_NRPS_GliP_like |
cd17653 |
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ... |
35-523 |
6.75e-25 |
|
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 108.94 E-value: 6.75e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahdvhal 114
Cdd:cd17653 10 HPDAVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGA----------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 cqiarpvAYIIPDcihgfdyremarevAASCPELEHIIVDGEAEEFIPFASIEDeplniigpgygDIAVLLLSGGTTGTP 194
Cdd:cd17653 73 -------AYVPLD--------------AKLPSARIQAILRTSGATLLLTTDSPD-----------DLAYIIFTSGSTGIP 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 195 KLIPRTHDAYTyNFVL--SARLcAINTESVYLAVLPVAHNFILGSpgILGTLSQGGCVLLSDTAScdeamPLIEEHK-VT 271
Cdd:cd17653 121 KGVMVPHRGVL-NYVSqpPARL-DVGPGSRVAQVLSIAFDACIGE--IFSTLCNGGTLVLADPSD-----PFAHVARtVD 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVP-ALARLweqardwEQSDLSSLRCLQVGGGRLTPELAEqvmaRLGP---LQQVFGTAEGLLC--YTRLDDPYEVI 345
Cdd:cd17653 192 ALMSTPsILSTL-------SPQDFPNLKTIFLGGEAVPPSLLD----RWSPgrrLYNAYGPTECTISstMTELLPGQPVT 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 346 IntqGRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRIRPDGNL 419
Cdd:cd17653 261 I---GKPIPNST-CYILDADLQPVPEGVVGEICISGVQVARGYLGNPALTASKFVPDPFwpgsrmYRTGDYGRWTEDGGL 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 420 LVEGRIKEQINRSGEKISTLEVE-TLLLQHPDIDDTVVIAVpdellGERICACL-PKSInqpDPAQMQAFLhQKGVQRHK 497
Cdd:cd17653 337 EFLGREDNQVKVRGFRINLEEIEeVVLQSQPEVTQAAAIVV-----NGRLVAFVtPETV---DVDGLRSEL-AKHLPSYA 407
|
490 500
....*....|....*....|....*.
gi 2740590833 498 IPDQWLFVAYWPLTAVGKINKRQLVQ 523
Cdd:cd17653 408 VPDRIIALDSFPLTANGKVDRKALRE 433
|
|
| PRK07059 |
PRK07059 |
Long-chain-fatty-acid--CoA ligase; Validated |
35-521 |
1.27e-24 |
|
Long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 109.72 E-value: 1.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPV----LLMPTQRAHD 110
Cdd:PRK07059 36 YADRPAFICMGKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAIAAVLRAGYVVVnvnpLYTPRELEHQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 111 V---------------HALCQIAR--PVAYII----------PDCIHGFDYREMAREVAA----SCPELEHIIVDGEAEE 159
Cdd:PRK07059 116 LkdsgaeaivvlenfaTTVQQVLAktAVKHVVvasmgdllgfKGHIVNFVVRRVKKMVPAwslpGHVRFNDALAEGARQT 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 160 FIPFAsiedeplniIGPGygDIAVLLLSGGTTGTPKLIPRTHDAYTYNfVLSARL---CAINT-----ESVYLAVLPVAH 231
Cdd:PRK07059 196 FKPVK---------LGPD--DVAFLQYTGGTTGVSKGATLLHRNIVAN-VLQMEAwlqPAFEKkprpdQLNFVCALPLYH 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 232 NFILGSPGILGtLSQGGCVLL----SDTAScdeampLIEEHKVTHLALVPALARLWE---QARDWEQSDLSSLRcLQVGG 304
Cdd:PRK07059 264 IFALTVCGLLG-MRTGGRNILipnpRDIPG------FIKELKKYQVHIFPAVNTLYNallNNPDFDKLDFSKLI-VANGG 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 305 GRLTPE-LAEQVMARLG-PLQQVFGTAEG--LLCYTRLDDPyeVIINTQGRPLSEEdEINLADTNLQPVAPSEVGELITR 380
Cdd:PRK07059 336 GMAVQRpVAERWLEMTGcPITEGYGLSETspVATCNPVDAT--EFSGTIGLPLPST-EVSIRDDDGNDLPLGEPGEICIR 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 381 GPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVP 460
Cdd:PRK07059 413 GPQVMAGYWNRPDETAKVMTADGFFRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVASHPGVLEVAAVGVP 492
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2740590833 461 DELLGERICACLPKSinqpDP----AQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK07059 493 DEHSGEAVKLFVVKK----DPalteEDVKAFCKER-LTNYKRPKFVEFRTELPKTNVGKILRREL 552
|
|
| MACS_euk |
cd05928 |
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ... |
45-521 |
5.28e-24 |
|
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.
Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 107.55 E-value: 5.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 45 EQRLTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGahpVLLMP--TQ-RAHDVHALCQIARP 120
Cdd:cd05928 39 EVKWSFRELGSLSRKAANVLSGAcGLQRGDRVAVILPRVPEWWLVNVACIRTG---LVFIPgtIQlTAKDILYRLQASKA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 121 VAYIIPDcihgfdyrEMAREV---AASCPELE-HIIVD-------GEAEEFIPFASIEDeplNIIGPGYGDIAVLLLSGG 189
Cdd:cd05928 116 KCIVTSD--------ELAPEVdsvASECPSLKtKLLVSeksrdgwLNFKELLNEASTEH---HCVETGSQEPMAIYFTSG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 190 TTGTPKLIPRTHDAYTYNFVLSARLCAINTESvylavlPVAHNF--------ILGSpgILGTLSQGGCVLLSDTASCDEA 261
Cdd:cd05928 185 TTGSPKMAEHSHSSLGLGLKVNGRYWLDLTAS------DIMWNTsdtgwiksAWSS--LFEPWIQGACVFVHHLPRFDPL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 262 MPL--IEEHKVTHLALVPALARLWEQaRDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAE-GLLCYTR 337
Cdd:cd05928 257 VILktLSSYPITTFCGAPTVYRMLVQ-QDLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGlDIYEGYGQTEtGLICANF 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 338 ldDPYEVIINTQGRPLSEEDeINLADTNLQPVAPSEVGELITR----GPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRI 413
Cdd:cd05928 336 --KGMKIKPGSMGKASPPYD-VQIIDDNGNVLPPGTEGDIGIRvkpiRPFGLFSGYVDNPEKTAATIRGDFYLTGDRGIM 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 414 RPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSINQPDPAQMQAFL--H 489
Cdd:cd05928 413 DEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAfvVLAPQFLSHDPEQLTKELqqH 492
|
490 500 510
....*....|....*....|....*....|...
gi 2740590833 490 QKGVQR-HKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05928 493 VKSVTApYKYPRKVEFVQELPKTVTGKIQRNEL 525
|
|
| PRK07787 |
PRK07787 |
acyl-CoA synthetase; Validated |
147-523 |
4.92e-23 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 103.92 E-value: 4.92e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 147 ELEHIIVDGEAEEFIPFASIEDEPLNII-------------GPGYGDIAVLLLSGGTTGTPK--LIPRThdaytynfVLS 211
Cdd:PRK07787 83 ERRHILADSGAQAWLGPAPDDPAGLPHVpvrlharswhrypEPDPDAPALIVYTSGTTGPPKgvVLSRR--------AIA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 212 ARLCAI------NTESVYLAVLPV--AHNFILGspgILGTLSQGGCVLLSDTAScDEAMPLIEEHKVTHLALVPALarlW 283
Cdd:PRK07787 155 ADLDALaeawqwTADDVLVHGLPLfhVHGLVLG---VLGPLRIGNRFVHTGRPT-PEAYAQALSEGGTLYFGVPTV---W 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 284 EQ-ARDWEQSD-LSSLRCLQVGGGRLTPELAEQVMARLGplQQV---FGTAEGLL-CYTRLDDPYEViiNTQGRPLSEEd 357
Cdd:PRK07787 228 SRiAADPEAARaLRGARLLVSGSAALPVPVFDRLAALTG--HRPverYGMTETLItLSTRADGERRP--GWVGLPLAGV- 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 358 EINLADTNLQPVA--PSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGR-----IKEqin 430
Cdd:PRK07787 303 ETRLVDEDGGPVPhdGETVGELQVRGPTLFDGYLNRPDATAAAFTADGWFRTGDVAVVDPDGMHRIVGRestdlIKS--- 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 431 rSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSiNQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPL 510
Cdd:PRK07787 380 -GGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIVAYVVGA-DDVAADELIDFVAQQ-LSVHKRPREVRFVDALPR 456
|
410
....*....|...
gi 2740590833 511 TAVGKINKRQLVQ 523
Cdd:PRK07787 457 NAMGKVLKKQLLS 469
|
|
| PRK08751 |
PRK08751 |
long-chain fatty acid--CoA ligase; |
48-527 |
1.12e-22 |
|
long-chain fatty acid--CoA ligase;
Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 103.42 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDV-HALCQIARPVAYII 125
Cdd:PRK08751 51 ITYREADQLVEQFAAYLLGElQLKKGDRVALMMPNCLQYPIATFGVLRAGLTVVNVNPLYTPRELkHQLIDSGASVLVVI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 PDcihgfdYREMAREVAASCPeLEHIIVDGEAEEF-IPFASIEDEPLNIIG---PGY----------------------- 178
Cdd:PRK08751 131 DN------FGTTVQQVIADTP-VKQVITTGLGDMLgFPKAALVNFVVKYVKklvPEYringairfrealalgrkhsmptl 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 179 ----GDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTE-----SVYLAVLPVAHNFILGSPGILgTLSQGGC 249
Cdd:PRK08751 204 qiepDDIAFLQYTGGTTGVAKGAMLTHRNLVANMQQAHQWLAGTGKleegcEVVITALPLYHIFALTANGLV-FMKIGGC 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 250 VLLsdtASCDEAMP-LIEEHKVTHLALVPALARLWEQARD---WEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQ 324
Cdd:PRK08751 283 NHL---ISNPRDMPgFVKELKKTRFTAFTGVNTLFNGLLNtpgFDQIDFSSLKMTLGGGMAVQRSVAERWKQVTGlTLVE 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 325 VFGTAEG--LLCYTRLD-DPYEVIIntqGRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTT 401
Cdd:PRK08751 360 AYGLTETspAACINPLTlKEYNGSI---GLPIPSTD-ACIKDDAGTVLAIGEIGELCIKGPQVMKGYWKRPEETAKVMDA 435
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 402 DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSinqpDP 481
Cdd:PRK08751 436 DGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGVLEVAAVGVPDEKSGEIVKVVIVKK----DP 511
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 2740590833 482 ---AQMQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQA 527
Cdd:PRK08751 512 altAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELRDAAKA 560
|
|
| PRK13567 |
PRK13567 |
anthranilate synthase component I; Provisional |
781-968 |
2.81e-22 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184148 [Multi-domain] Cd Length: 468 Bit Score: 101.37 E-value: 2.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 781 GFSPETVVEAEGsGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAIC 860
Cdd:PRK13567 270 GSSPESFVSVKD-QIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIE 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 861 ERGSVQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTIsrYEGEP--RRLYSGCVMLLDSTGKLDAALVLR 938
Cdd:PRK13567 349 KYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERI--YEQYPhkRGVYSGGVGYINCNHNLDFALAIR 426
|
170 180 190
....*....|....*....|....*....|
gi 2740590833 939 SLYQHKERCWLQAGAGLVRNSRPEREWQET 968
Cdd:PRK13567 427 TMMIDEQYINVEAGCGVVYDSIPEKELNET 456
|
|
| ttLC_FACS_like |
cd05915 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
34-521 |
3.51e-22 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.
Pssm-ID: 213283 [Multi-domain] Cd Length: 509 Bit Score: 101.35 E-value: 3.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 34 IWGNKTaliYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHA 113
Cdd:cd05915 14 VSRLHT---GEVHRTTYAEVYQRARRLMGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 LCQIARPVAYIIPDcihgfDYREMAREVAASCPEL-EHIIVDGEAEEFIPFASIEDEPLNIIGP-GYGDIAVLLLSGGTT 191
Cdd:cd05915 91 ILNHAEDKVLLFDP-----NLLPLVEAIRGELKTVqHFVVMDEKAPEGYLAYEEALGEEADPVRvPERAACGMAYTTGTT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 192 GTPKLIPRTHDAYTYNFVLSARLCAINTES--VYLAVLPVAHnfILGSPGILGTLSQGGCVLLSDTASCDEAM-PLIEEH 268
Cdd:cd05915 166 GLPKGVVYSHRALVLHSLAASLVDGTALSEkdVVLPVVPMFH--VNAWCLPYAATLVGAKQVLPGPRLDPASLvELFDGE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 269 KVTHLALVPALARLWEQARDWEQSDLSslRCLQVGGGRLTPELAEQVMARLGPLQ--QVFGTAE--GLLCYTRLDDPYEV 344
Cdd:cd05915 244 GVTFTAGVPTVWLALADYLESTGHRLK--TLRRLVVGGSAAPRSLIARFERMGVEvrQGYGLTEtsPVVVQNFVKSHLES 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 345 IINTQGRPLSEEDEINLADTNLQPVAPSEV-----GELIT----RGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRP 415
Cdd:cd05915 322 LSEEEKLTLKAKTGLPIPLVRLRVADEEGRpvpkdGKALGevqlKGPWITGGYYGNEEATRSALTPDGFFRTGDIAVWDE 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 416 DGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKGVQR 495
Cdd:cd05915 402 EGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAVVVPRGEKPTPEELNEHLLKAGFAK 481
|
490 500
....*....|....*....|....*.
gi 2740590833 496 HKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd05915 482 WQLPDAYVFAEEIPRTSAGKFLKRAL 507
|
|
| A_NRPS_LgrA-like |
cd17645 |
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ... |
37-521 |
3.72e-22 |
|
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.
Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 100.71 E-value: 3.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPtqrahdvhalcq 116
Cdd:cd17645 13 DHVAVVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP------------ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 iarpvayiipdcihgfDYREmarevaascPELEHIIVDGEAEEFIPFAsiedeplniigpgyGDIAVLLLSGGTTGTPKL 196
Cdd:cd17645 81 ----------------DYPG---------ERIAYMLADSSAKILLTNP--------------DDLAYVIYTSGSTGLPKG 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAYTyNFVLSARLC----AINTESVYLAVlpvahNFILGSPGILGTLSQGGCVLLSDTAS---CDEAMPLIEEHK 269
Cdd:cd17645 122 VMIEHHNLV-NLCEWHRPYfgvtPADKSLVYASF-----SFDASAWEIFPHLTAGAALHVVPSERrldLDALNDYFNQEG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 270 VThLALVPALArlweqARDWEQSDLSSLRCLQVGGGRLTpelaeqvMARLGPLQQV--FGTAEGLLCYT--RLDDPYEVI 345
Cdd:cd17645 196 IT-ISFLPTGA-----AEQFMQLDNQSLRVLLTGGDKLK-------KIERKGYKLVnnYGPTENTVVATsfEIDKPYANI 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 346 inTQGRPLSEEDEINLADTN-LQPVAPSevGELITRGPYTITGYYRAEQHNTVAFTTDGF------YRTGDLVRIRPDGN 418
Cdd:cd17645 263 --PIGKPIDNTRVYILDEALqLQPIGVA--GELCIAGEGLARGYLNRPELTAEKFIVHPFvpgermYRTGDLAKFLPDGN 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 419 LLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICA--CLPKSInqpDPAQMQAFLhQKGVQRH 496
Cdd:cd17645 339 IEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEDADGRKYLVAyvTAPEEI---PHEELREWL-KNDLPDY 414
|
490 500
....*....|....*....|....*
gi 2740590833 497 KIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17645 415 MIPTYFVHLKALPLTANGKVDRKAL 439
|
|
| FACL_like_1 |
cd05910 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
46-459 |
4.98e-22 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 100.61 E-value: 4.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPtqrahdvhalcqiarpvayii 125
Cdd:cd05910 1 SRLSFRELDERSDRIAQGLTAYGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDP--------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 pdcihGFDYREMARevaasCpelehiivdgeaeefipfaSIEDEPLNIIG-PGYGDIAVLLLSGGTTGTPKLIPRTHDAY 204
Cdd:cd05910 60 -----GMGRKNLKQ-----C-------------------LQEAEPDAFIGiPKADEPAAILFTSGSTGTPKGVVYRHGTF 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 205 TYNFVLSARLCAINTESVYLAVLPVahnFILGSPgILGTLSQGGCVLLSDTASCD--EAMPLIEEHKVTHLALVPALARL 282
Cdd:cd05910 111 AAQIDALRQLYGIRPGEVDLATFPL---FALFGP-ALGLTSVIPDMDPTRPARADpqKLVGAIRQYGVSIVFGSPALLER 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 283 WEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVF---GTAEGL-----------------------LCYT 336
Cdd:cd05910 187 VARYCAQHGITLPSLRRVLSAGAPVPIALAARLRKMLSDEAEILtpyGATEALpvssigsrellatttaatsggagTCVG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 RLDDPYEV-IIntqgrPLSEEDEINLADTNLQPvaPSEVGELITRGPYTITGYYRAEQHNTVAFTTDG----FYRTGDLV 411
Cdd:cd05910 267 RPIPGVRVrII-----EIDDEPIAEWDDTLELP--RGEIGEITVTGPTVTPTYVNRPVATALAKIDDNsegfWHRMGDLG 339
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2740590833 412 RIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAV 459
Cdd:cd05910 340 YLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV 387
|
|
| PRK07638 |
PRK07638 |
acyl-CoA synthetase; Validated |
37-526 |
5.52e-22 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 100.62 E-value: 5.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLyHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQ 116
Cdd:PRK07638 16 NKIAIKENDRVLTYKDWFESVCKVANWL-NEKESKNKTIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDELKERLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 117 IARPVAYIIpdcihgfDYREMAREVAASCP--ELEHI--IVDGEAEEFIPFASIEDEPLNIigpGYgdiavlllSGGTTG 192
Cdd:PRK07638 95 ISNADMIVT-------ERYKLNDLPDEEGRviEIDEWkrMIEKYLPTYAPIENVQNAPFYM---GF--------TSGSTG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 193 TPKLIPRTHDAYTYNFVLSARLCAINTE-SVYLAVLPVAHNFILGSpgiLGTLSQGGCVLLSDTASCDEAMPLIEEHKVT 271
Cdd:PRK07638 157 KPKAFLRAQQSWLHSFDCNVHDFHMKREdSVLIAGTLVHSLFLYGA---ISTLYVGQTVHLMRKFIPNQVLDKLETENIS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 272 HLALVPA-LARLWEQARDWEQSD--LSSlrclqvggGRLTPELAEQVMARLGP---LQQVFGTAEGLLCYTRLDDPYEVI 345
Cdd:PRK07638 234 VMYTVPTmLESLYKENRVIENKMkiISS--------GAKWEAEAKEKIKNIFPyakLYEFYGASELSFVTALVDEESERR 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 346 INTQGRPLSE-EDEI-NLADTNLQPvapSEVGELITRGPYTITGYyRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEG 423
Cdd:PRK07638 306 PNSVGRPFHNvQVRIcNEAGEEVQK---GEIGTVYVKSPQFFMGY-IIGGVLARELNADGWMTVRDVGYEDEEGFIYIVG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 424 RIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQpdpAQMQAFLHQKgVQRHKIPDQWL 503
Cdd:PRK07638 382 REKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGEKPVAIIKGSATK---QQLKSFCLQR-LSSFKIPKEWH 457
|
490 500
....*....|....*....|...
gi 2740590833 504 FVAYWPLTAVGKINKRQLVQMAQ 526
Cdd:PRK07638 458 FVDEIPYTNSGKIARMEAKSWIE 480
|
|
| PLN02330 |
PLN02330 |
4-coumarate--CoA ligase-like 1 |
49-521 |
6.10e-22 |
|
4-coumarate--CoA ligase-like 1
Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 101.21 E-value: 6.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 49 TYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYIIPDC 128
Cdd:PLN02330 57 TYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAKLIVTNDT 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 129 IHG---------FDYREMAREVAASCPELEhiivdgEAEEFIPFASIEDEPLNiigpgyGDIAVLLLSGGTTGTPKLIPR 199
Cdd:PLN02330 137 NYGkvkglglpvIVLGEEKIEGAVNWKELL------EAADRAGDTSDNEEILQ------TDLCALPFSSGTTGISKGVML 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 THDAYTYNfvLSARLCAINTESV----YLAVLPVAHnfILGSPGI-LGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLA 274
Cdd:PLN02330 205 THRNLVAN--LCSSLFSVGPEMIgqvvTLGLIPFFH--IYGITGIcCATLRNKGKVVVMSRFELRTFLNALITQEVSFAP 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 275 LVPALARLWEQARDWEQSDLSSL--RCLQVGGGRLTPELAEQVMARLG--PLQQVFGTAEGLLCYTRLDDPyeviinTQG 350
Cdd:PLN02330 281 IVPPIILNLVKNPIVEEFDLSKLklQAIMTAAAPLAPELLTAFEAKFPgvQVQEAYGLTEHSCITLTHGDP------EKG 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 351 RPLSEEDEINLADTNL----------QPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLL 420
Cdd:PLN02330 355 HGIAKKNSVGFILPNLevkfidpdtgRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIDEDGWLHTGDIGYIDDDGDIF 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 421 VEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLpkSINQPDPAQMQAFLH--QKGVQRHKI 498
Cdd:PLN02330 435 IVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPLPDEEAGEIPAACV--VINPKAKESEEDILNfvAANVAHYKK 512
|
490 500
....*....|....*....|...
gi 2740590833 499 PDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PLN02330 513 VRVVQFVDSIPKSLSGKIMRRLL 535
|
|
| PLN02479 |
PLN02479 |
acetate-CoA ligase |
34-521 |
2.48e-21 |
|
acetate-CoA ligase
Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 99.15 E-value: 2.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 34 IWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISF------------VVTCFALfRLGAHPV- 100
Cdd:PLN02479 32 VHPTRKSVVHGSVRYTWAQTYQRCRRLASALAKRSIGPGSTVAVIAPNIPAMyeahfgvpmagaVVNCVNI-RLNAPTIa 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 101 LLMPTQRAHDV-------------------HALCQIARPVAYIIPDciHGFDYREMAREVAASCPELEHIIVDGEAEefI 161
Cdd:PLN02479 111 FLLEHSKSEVVmvdqefftlaeealkilaeKKKSSFKPPLLIVIGD--PTCDPKSLQYALGKGAIEYEKFLETGDPE--F 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 162 PFASIEDEpLNIIGPGYgdiavlllSGGTTGTPKLIPRTHDAyTYNFVLSARLC-AINTESVYLAVLPVAHnfilgspgi 240
Cdd:PLN02479 187 AWKPPADE-WQSIALGY--------TSGTTASPKGVVLHHRG-AYLMALSNALIwGMNEGAVYLWTLPMFH--------- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 241 lgtlSQGGCVLLSDTASCDEAMPL-----------IEEHKVTHLALVPALARLWEQARDWEQS-DLSSLRCLQVGGGRLT 308
Cdd:PLN02479 248 ----CNGWCFTWTLAALCGTNICLrqvtakaiysaIANYGVTHFCAAPVVLNTIVNAPKSETIlPLPRVVHVMTAGAAPP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 309 PELAEQVMARLGPLQQVFGTAE----GLLC-----YTRLDDPYEVIINT-QGRPLSEEDEINLADT-NLQPVAP--SEVG 375
Cdd:PLN02479 324 PSVLFAMSEKGFRVTHTYGLSEtygpSTVCawkpeWDSLPPEEQARLNArQGVRYIGLEGLDVVDTkTMKPVPAdgKTMG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 376 ELITRGPYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTV 455
Cdd:PLN02479 404 EIVMRGNMVMKGYLKNPKANEEAFA-NGWFHSGDLGVKHPDGYIEIKDRSKDIIISGGENISSLEVENVVYTHPAVLEAS 482
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 456 VIAVPDELLGERICA--CLPKSINQPDPAQMQAFLHQkgVQRHKIPDQWL--FVAYWPL--TAVGKINKRQL 521
Cdd:PLN02479 483 VVARPDERWGESPCAfvTLKPGVDKSDEAALAEDIMK--FCRERLPAYWVpkSVVFGPLpkTATGKIQKHVL 552
|
|
| A_NRPS_ACVS-like |
cd17648 |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ... |
37-521 |
6.44e-21 |
|
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.
Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 97.09 E-value: 6.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDH-VMVQLPNRISFVVTCFALFRLGAHPVLLMPTqrahdvhalc 115
Cdd:cd17648 2 DRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIRPDDlVGLVLDKSELMIIAILAVWKAGAAYVPIDPS---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 116 qiarpvaYiiPDcihgfdyremarevaascpelehiivdgEAEEFIpfasIEDEPLNIIGPGYGDIAVLLLSGGTTGTPK 195
Cdd:cd17648 72 -------Y--PD----------------------------ERIQFI----LEDTGARVVITNSTDLAYAIYTSGTTGKPK 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 196 LIPRTHDAyTYNFV--LSARLCAINTEsvYLAVLPVAhNFILgSPGI----LGTLSQGGCVLLSDTASCD--EAMPLIEE 267
Cdd:cd17648 111 GVLVEHGS-VVNLRtsLSERYFGRDNG--DEAVLFFS-NYVF-DFFVeqmtLALLNGQKLVVPPDEMRFDpdRFYAYINR 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 268 HKVTHLALVPALARLWEQARdweqsdLSSLRCLQVGGGRLTPELAEQVMARL-GPLQQVFGTAE-GLLCYTRLDDPYEVI 345
Cdd:cd17648 186 EKVTYLSGTPSVLQQYDLAR------LPHLKRVDAAGEEFTAPVFEKLRSRFaGLIINAYGPTEtTVTNHKRFFPGDQRF 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 346 INTQGRPLSEEDEINLADtNLQPVAPSEVGELITRGPYTITGYyraeqHNTVAFTTDGF-------------------YR 406
Cdd:cd17648 260 DKSLGRPVRNTKCYVLND-AMKRVPVGAVGELYLGGDGVARGY-----LNRPELTAERFlpnpfqteqerargrnarlYK 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 407 TGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDE----------LLGERICAclPKSI 476
Cdd:cd17648 334 TGDLVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVVAKEDAsqaqsriqkyLVGYYLPE--PGHV 411
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 2740590833 477 nqpDPAQMQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17648 412 ---PESDLLSFLRAK-LPRYMVPARLVRLEGIPVTINGKLDVRAL 452
|
|
| A_NRPS_acs4 |
cd17654 |
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ... |
181-521 |
6.53e-21 |
|
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 96.77 E-value: 6.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 181 IAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVY-LAVLPVAHNFILGspgILGTLSQGGCVLLSDTASCD 259
Cdd:cd17654 120 LAYVIHTSGTTGTPKIVAVPHKCILPNIQHFRSLFNITSEDILfLTSPLTFDPSVVE---IFLSLSSGATLLIVPTSVKV 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 260 E----AMPLIEEHKVTHLALVPALARLW--EQARDWEQSDLSSLRCLQVGGgRLTPELAEQVMARLGPLQ----QVFGTA 329
Cdd:cd17654 197 LpsklADILFKRHRITVLQATPTLFRRFgsQSIKSTVLSATSSLRVLALGG-EPFPSLVILSSWRGKGNRtrifNIYGIT 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 330 EgLLCYTRLddpYEVIINTQGRPLSEEDE---INLADTNLQPVAPSEVGELITRGpytitgYYRAEQHNTVAFTtdgFYR 406
Cdd:cd17654 276 E-VSCWALA---YKVPEEDSPVQLGSPLLgtvIEVRDQNGSEGTGQVFLGGLNRV------CILDDEVTVPKGT---MRA 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 407 TGDLVRIRpDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDEllgeRICACLpksINQPDPAQMQA 486
Cdd:cd17654 343 TGDFVTVK-DGELFFLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAVTLSDQQ----RLIAFI---VGESSSSRIHK 414
|
330 340 350
....*....|....*....|....*....|....*
gi 2740590833 487 FLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:cd17654 415 ELQLTLLSSHAIPDTFVQIDKLPLTSHGKVDKSEL 449
|
|
| PRK07508 |
PRK07508 |
aminodeoxychorismate synthase component I; |
771-977 |
7.78e-21 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236035 [Multi-domain] Cd Length: 378 Bit Score: 95.85 E-value: 7.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 771 FLRDGDFSAYGFSPETVVEAEGSGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPET 850
Cdd:PRK07508 165 LVDLGGPVILSRSPELFFRVDGEGWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGS 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 851 LCVSEFMAICERGSVQHLASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGK 930
Cdd:PRK07508 245 LDVPELFDIETYPTVHQMVSRVRARLLPGLGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGR 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2740590833 931 LDAALVLRSLYQHKE-RCWLQAGAGLVRNSRPEREWQetceklECIMK 977
Cdd:PRK07508 325 MRFNVAIRTLSLFPGgRAVFNVGGGIVFDSTAEAEYE------ECLLK 366
|
|
| MACS_like_1 |
cd05974 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
48-463 |
8.21e-21 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 96.48 E-value: 8.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvLLMPTqrahdvhalcqiarpVAYIIPD 127
Cdd:cd05974 1 VSFAEMSARSSRVANFLRSIGVGRGDRILLMLGNVVELWEAMLAAMKLGA---VVIPA---------------TTLLTPD 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 128 CIHgfDYREMAREVAASCPELEHiivdgeaeefipfasiEDEPLniigpgygdiaVLLLSGGTTGTPKLIPRTHDAYTYN 207
Cdd:cd05974 63 DLR--DRVDRGGAVYAAVDENTH----------------ADDPM-----------LLYFTSGTTSKPKLVEHTHRSYPVG 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 208 FVLSARLCAINTESVYLAVlpvahnfilGSPG--------ILGTLSQGGCVLLSDTASCD--EAMPLIEEHKVTHLALVP 277
Cdd:cd05974 114 HLSTMYWIGLKPGDVHWNI---------SSPGwakhawscFFAPWNAGATVFLFNYARFDakRVLAALVRYGVTTLCAPP 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 278 ALARLWEQArdweqsDLSSLRCLQ---VGGGR-LTPELAEQVMARLG-PLQQVFGTAEGLLCYTrlDDPYEVI-INTQGR 351
Cdd:cd05974 185 TVWRMLIQQ------DLASFDVKLrevVGAGEpLNPEVIEQVRRAWGlTIRDGYGQTETTALVG--NSPGQPVkAGSMGR 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 352 PLSEEdEINLADTNLQPVAPSEVG-ELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQIN 430
Cdd:cd05974 257 PLPGY-RVALLDPDGAPATEGEVAlDLGDTRPVGLMKGYAGDPDKTAHAMRGGYYRTGDIAMRDEDGYLTYVGRADDVFK 335
|
410 420 430
....*....|....*....|....*....|...
gi 2740590833 431 RSGEKISTLEVETLLLQHPDIDDTVVIAVPDEL 463
Cdd:cd05974 336 SSDYRISPFELESVLIEHPAVAEAAVVPSPDPV 368
|
|
| PRK06334 |
PRK06334 |
long chain fatty acid--[acyl-carrier-protein] ligase; Validated |
172-478 |
2.30e-20 |
|
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 96.04 E-value: 2.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 172 NIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVL 251
Cdd:PRK06334 176 GVSDKDPEDVAVILFTSGTEKLPKGVPLTHANLLANQRACLKFFSPKEDDVMMSFLPPFHAYGFNSCTLFPLLSGVPVVF 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 252 LSDTASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMaRLGP---LQQVFGT 328
Cdd:PRK06334 256 AYNPLYPKKIVEMIDEAKVTFLGSTPVFFDYILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEAL-KTFPhiqLRQGYGT 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 329 AEgllCytrldDPYeVIINTQGRPLSEE---------DEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNT-VA 398
Cdd:PRK06334 335 TE---C-----SPV-ITINTVNSPKHEScvgmpirgmDVLIVSEETKVPVSSGETGLVLTRGTSLFSGYLGEDFGQGfVE 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 399 FTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQH---PDIDDT---VVIAVPdellGERICACL 472
Cdd:PRK06334 406 LGGETWYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEALESILMEGfgqNAADHAgplVVCGLP----GEKVRLCL 481
|
330
....*....|
gi 2740590833 473 ----PKSINQ 478
Cdd:PRK06334 482 fttfPTSISE 491
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
13-521 |
9.06e-20 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 96.01 E-value: 9.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 13 MTPNYLWNGKTLDQQLAGWSsiwgNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFAL 92
Cdd:PRK05691 1126 CAPAQAWLPELLNEQARQTP----ERIALVWDGGSLDYAELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAI 1201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 93 FRLGAHPVLL---MPTQRahdvhalcqiarpVAYIIPDCihGFDYREMAREVAASCPELEHIIVdgeaeefIPFASIEDE 169
Cdd:PRK05691 1202 LKAGGAYVPLdpdYPAER-------------LAYMLADS--GVELLLTQSHLLERLPQAEGVSA-------IALDSLHLD 1259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 170 PLNIIGPG---YGD-IAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGS---PGIlg 242
Cdd:PRK05691 1260 SWPSQAPGlhlHGDnLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYALDDSDVLMQKAPISFDVSVWEcfwPLI-- 1337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 243 tlsqGGC--VLLSDTASCDEA--MPLIEEHKVTHLALVPALARLWEQARDweQSDLSSLRCLQVGGGRLTPELAEQVMAR 318
Cdd:PRK05691 1338 ----TGCrlVLAGPGEHRDPQriAELVQQYGVTTLHFVPPLLQLFIDEPL--AAACTSLRRLFSGGEALPAELRNRVLQR 1411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 319 LGPLQ--QVFGTAEGLLCYT----RLDDPYEVIIntqGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYR-- 390
Cdd:PRK05691 1412 LPQVQlhNRYGPTETAINVThwqcQAEDGERSPI---GRPLGNV-LCRVLDAELNLLPPGVAGELCIGGAGLARGYLGrp 1487
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 391 ---AEQHNTVAFTTDG--FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIaVPDELLG 465
Cdd:PRK05691 1488 altAERFVPDPLGEDGarLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQAAVL-VREGAAG 1566
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 2740590833 466 ERICACLPKSINQPDPAQ-MQAFLHQKgVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK05691 1567 AQLVGYYTGEAGQEAEAErLKAALAAE-LPEYMVPAQLIRLDQMPLGPSGKLDRRAL 1622
|
|
| PRK04319 |
PRK04319 |
acetyl-CoA synthetase; Provisional |
24-521 |
1.16e-19 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 94.19 E-value: 1.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 24 LDQQLAGWSsiwGNKTALIY----HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPnRI--------------SF 85
Cdd:PRK04319 49 IDRHADGGR---KDKVALRYldasRKEKYTYKELKELSNKFANVLKELGVEKGDRVFIFMP-RIpelyfallgalkngAI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 86 VVTCFALFrlGAHPVllmpTQRAHDVHALCQIARPVAYiipdcihgfdyremAREVAASCPELEHIIVDGEAEEFIP--- 162
Cdd:PRK04319 125 VGPLFEAF--MEEAV----RDRLEDSEAKVLITTPALL--------------ERKPADDLPSLKHVLLVGEDVEEGPgtl 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 163 -----FASIEDEpLNIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDA-----YTYNFVLSAR-----LCAIN----TESVY 223
Cdd:PRK04319 185 dfnalMEQASDE-FDIEWTDREDGAILHYTSGSTGKPKGVLHVHNAmlqhyQTGKYVLDLHeddvyWCTADpgwvTGTSY 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 224 lavlpvahnfilgspGILGTLSQGG-CVLLSDTASCDEAMPLIEEHKVTHLALVPALARLWEQARD--WEQSDLSSLRCL 300
Cdd:PRK04319 264 ---------------GIFAPWLNGAtNVIDGGRFSPERWYRILEDYKVTVWYTAPTAIRMLMGAGDdlVKKYDLSSLRHI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 301 QVGGGRLTPElaeqvMARLGplQQVFG---------TAEG--LLCYTRLDDpyeVIINTQGRPLSEEdEINLADTNLQPV 369
Cdd:PRK04319 329 LSVGEPLNPE-----VVRWG--MKVFGlpihdnwwmTETGgiMIANYPAMD---IKPGSMGKPLPGI-EAAIVDDQGNEL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 370 APSEVGEL-ITRG-PYTITGYYRAEQHNTVAFTtDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQ 447
Cdd:PRK04319 398 PPNRMGNLaIKKGwPSMMRGIWNNPEKYESYFA-GDWYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLME 476
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2740590833 448 HPDIDDTVVIAVPDELLGERICA--CLpKSINQPDPA---QMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK04319 477 HPAVAEAGVIGKPDPVRGEIIKAfvAL-RPGYEPSEElkeEIRGFV-KKGLGAHAAPREIEFKDKLPKTRSGKIMRRVL 553
|
|
| PRK05620 |
PRK05620 |
long-chain fatty-acid--CoA ligase; |
32-523 |
2.88e-19 |
|
long-chain fatty-acid--CoA ligase;
Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 92.92 E-value: 2.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 32 SSIWGNKTALIYHE---QRLTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGA--HPV--LLM 103
Cdd:PRK05620 20 STVHGDTTVTTWGGaeqEQTTFAAIGARAAALAHALHDElGITGDQRVGSMMYNCAEHLEVLFAVACMGAvfNPLnkQLM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 104 PTQRAHDVH--------ALCQIARPVAYIIPDC--------IHGFDYREMAREVAA--SCPELEHIIvDGEAEEFiPFAS 165
Cdd:PRK05620 100 NDQIVHIINhaedevivADPRLAEQLGEILKECpcvravvfIGPSDADSAAAHMPEgiKVYSYEALL-DGRSTVY-DWPE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 166 IEDEplniigpgygDIAVLLLSGGTTGTPKLIPRTHDAYtYNFVLSAR----LCAINTESvYLAVLPVAHNFILGSPgIL 241
Cdd:PRK05620 178 LDET----------TAAAICYSTGTTGAPKGVVYSHRSL-YLQSLSLRttdsLAVTHGES-FLCCVPIYHVLSWGVP-LA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 242 GTLSQGGCVLLSDTASCDEAMPLIEEH--KVTHLalVPALarlWEQAR-DWEQS--DLSSLRCLQVGGGRLTPELAEQVM 316
Cdd:PRK05620 245 AFMSGTPLVFPGPDLSAPTLAKIIATAmpRVAHG--VPTL---WIQLMvHYLKNppERMSLQEIYVGGSAVPPILIKAWE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 317 ARLG-PLQQVFGTAE------------GLLCYTRldDPYEViinTQGR-PLSEEDEInLADTNLQPVAPSEVGELITRGP 382
Cdd:PRK05620 320 ERYGvDVVHVWGMTEtspvgtvarppsGVSGEAR--WAYRV---SQGRfPASLEYRI-VNDGQVMESTDRNEGEIQVRGN 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 383 YTITGYY--------------RAEQHNTVA--FTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLL 446
Cdd:PRK05620 394 WVTASYYhspteegggaastfRGEDVEDANdrFTADGWLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIM 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 447 QHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKGVQRHK---IPDQWLFVAYWPLTAVGKINKRQLVQ 523
Cdd:PRK05620 474 AAPEVVECAVIGYPDDKWGERPLAVTVLAPGIEPTRETAERLRDQLRDRLPnwmLPEYWTFVDEIDKTSVGKFDKKDLRQ 553
|
|
| LC_FACS_euk1 |
cd17639 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ... |
180-540 |
4.13e-19 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.
Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 91.89 E-value: 4.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHdaytYNFV-----LSARLC-AINTESVYLAVLPVAHNFILGSPGILgtLSQGGCV--- 250
Cdd:cd17639 89 DLACIMYTSGSTGNPKGVMLTH----GNLVagiagLGDRVPeLLGPDDRYLAYLPLAHIFELAAENVC--LYRGGTIgyg 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 ---LLSD--TASC--DeamplIEEHKVTHLALVPALarlWEQARDWEQSDLSS--------------------------- 296
Cdd:cd17639 163 sprTLTDksKRGCkgD-----LTEFKPTLMVGVPAI---WDTIRKGVLAKLNPmgglkrtlfwtayqsklkalkegpgtp 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 297 -----------------LRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEGLLCYTRLDdPYEVIINTQGRPLSEEdEI 359
Cdd:cd17639 235 lldelvfkkvraalggrLRYMLSGGAPLSADTQEFLNIVLCPVIQGYGLTETCAGGTVQD-PGDLETGRVGPPLPCC-EI 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 360 NLADT---NLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQI-NRSGEK 435
Cdd:cd17639 313 KLVDWeegGYSTDKPPPRGEILIRGPNVFKGYYKNPEKTKEAFDGDGWFHTGDIGEFHPDGTLKIIDRKKDLVkLQNGEY 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 436 ISTLEVETLLLQHPDIDDTVVIAVPDEllgERICAclpksINQPDPAQMQAFLHQKGVQRHKIPDQwlfvaywpltavgk 515
Cdd:cd17639 393 IALEKLESIYRSNPLVNNICVYADPDK---SYPVA-----IVVPNEKHLTKLAEKHGVINSEWEEL-------------- 450
|
410 420
....*....|....*....|....*
gi 2740590833 516 INKRQLVQMAQAENTETAENNSLMK 540
Cdd:cd17639 451 CEDKKLQKAVLKSLAETARAAGLEK 475
|
|
| PRK05857 |
PRK05857 |
fatty acid--CoA ligase; |
48-465 |
5.78e-19 |
|
fatty acid--CoA ligase;
Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 91.61 E-value: 5.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYII-P 126
Cdd:PRK05857 42 LRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVaP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 DCIHGfdyremarevAASCPELEH----IIVDGEAEEFIPFASIE-DEPLNIIGPGYGDIAVLLLSGGTTGTPK--LIP- 198
Cdd:PRK05857 122 GSKMA----------SSAVPEALHsipvIAVDIAAVTRESEHSLDaASLAGNADQGSEDPLAMIFTSGTTGEPKavLLAn 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 199 RTHdaYTYNFVLSARLCA----INTESVYlAVLPVAHnfILGSPGILGTLSQGG-CVLLSDTAScdEAMPLIEEHKVTHL 273
Cdd:PRK05857 192 RTF--FAVPDILQKEGLNwvtwVVGETTY-SPLPATH--IGGLWWILTCLMHGGlCVTGGENTT--SLLEILTTNAVATT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 274 ALVPAL-ARLWEQARdWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEG---LLCYTRLDDPYEVI-INT 348
Cdd:PRK05857 265 CLVPTLlSKLVSELK-SANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETgctALCLPTDDGSIVKIeAGA 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 349 QGRP-------LSEEDEinlADTNLQPVAPS-EVGELITRGPYTITGYYRAEQHnTVAFTTDGFYRTGDLVRIRPDGNLL 420
Cdd:PRK05857 344 VGRPypgvdvyLAATDG---IGPTAPGAGPSaSFGTLWIKSPANMLGYWNNPER-TAEVLIDGWVNTGDLLERREDGFFY 419
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2740590833 421 VEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLG 465
Cdd:PRK05857 420 IKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFG 464
|
|
| PLN02786 |
PLN02786 |
isochorismate synthase |
661-967 |
9.07e-19 |
|
isochorismate synthase
Pssm-ID: 178383 [Multi-domain] Cd Length: 533 Bit Score: 91.00 E-value: 9.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 661 TIPQHEL-----------RITQGQVLIRTLEEA---------QISILNEKVKRaDQLGTpafpqtkEVEIINTADTAKNY 720
Cdd:PLN02786 191 IVPQVEFnelggssmlaaTIAWDDALSWTWENAiealqetmlQVSSVVMKLRK-ESLGV-------SVLSKNHVPSKGAW 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 721 QDNVANAVKDIASGH--YQKVILSRQVELGSNIDITHSYWLGR-QANTP-ARSFFLRDGDFSAY-GFSPETVVEAEGSGw 795
Cdd:PLN02786 263 HLAVNKALQIIKRKSspLKKVVLARSSRIITDTDIDPIAWLAClQVEGQnAYQFCLQPPDAPAFiGNTPEQLFHRKGLG- 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 796 INTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAV---SVKLALEElapICqpETLCVSEFMAICERGSVQHLASRV 872
Cdd:PLN02786 342 VCSEALAATRPRGGSSARDLQIELDLLTSPKDDLEFSIvreNIREKLEA---IC--DRVVVEPHKAIRKLARVQHLYAQL 416
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 873 KGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAG 952
Cdd:PLN02786 417 AGRLRSEDDEFDILAALHPTPAVCGHPTEEARLLIAETESFDRGMYAGPVGWFGGGESEFAVGIRSALVEKGLGALIYAG 496
|
330
....*....|....*
gi 2740590833 953 AGLVRNSRPEREWQE 967
Cdd:PLN02786 497 TGIVEGSNPSSEWNE 511
|
|
| PRK09029 |
PRK09029 |
O-succinylbenzoic acid--CoA ligase; Provisional |
31-523 |
1.01e-18 |
|
O-succinylbenzoic acid--CoA ligase; Provisional
Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 90.32 E-value: 1.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 31 WSSIWGNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPtqrahd 110
Cdd:PRK09029 12 WAQVRPQAIALRLNDEVLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNP------ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 111 vhALCqiarpvayiipdcihgfdyremAREVAASCPEL--EHIIVDGEAEEFIPFASI-EDEPLNIIGPGYGD--IAVLL 185
Cdd:PRK09029 86 --QLP----------------------QPLLEELLPSLtlDFALVLEGENTFSALTSLhLQLVEGAHAVAWQPqrLATMT 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPKLIPRTHDAYTYNF--VLSarLCAINTESVYLAVLPVAHnfILGSpGILGT-LSQGGCVLLSDTASCDEAM 262
Cdd:PRK09029 142 LTSGSTGLPKAAVHTAQAHLASAegVLS--LMPFTAQDSWLLSLPLFH--VSGQ-GIVWRwLYAGATLVVRDKQPLEQAL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 263 plieeHKVTHLALVPA-LARLWeqarDWEQSDLSSLRCLqVGGGRLTPELAEQVMARlgplqqvfgtaeGLLCYT----- 336
Cdd:PRK09029 217 -----AGCTHASLVPTqLWRLL----DNRSEPLSLKAVL-LGGAAIPVELTEQAEQQ------------GIRCWCgyglt 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 ---------RLDDpyeviINTQGRPLSEEdEINLADtnlqpvapsevGELITRGPYTITGYYRaeQHNTVAFT-TDGFYR 406
Cdd:PRK09029 275 emastvcakRADG-----LAGVGSPLPGR-EVKLVD-----------GEIWLRGASLALGYWR--QGQLVPLVnDEGWFA 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 407 TGDLVRIRpDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLpKSINQPDPAQMQA 486
Cdd:PRK09029 336 TRDRGEWQ-NGELTILGRLDNLFFSGGEGIQPEEIERVINQHPLVQQVFVVPVADAEFGQRPVAVV-ESDSEAAVVNLAE 413
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2740590833 487 FLHQKgVQRHKIPdqwlfVAYWPLTAV----G-KINKRQLVQ 523
Cdd:PRK09029 414 WLQDK-LARFQQP-----VAYYLLPPElkngGiKISRQALKE 449
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
47-534 |
1.10e-18 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 91.95 E-value: 1.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHrGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIA--RPV--- 121
Cdd:PRK06814 658 PLTYRKLLTGAFVLGRKLKK-NTPPGENVGVMLPNANGAAVTFFALQSAGRVPAMINFSAGIANILSACKAAqvKTVlts 736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 122 -AYIipdcihgfdyrEMAR--EVAASCPELEHIIVdgeAEEFIPFASIEDEPLNIIGPGYG----------DIAVLLLSG 188
Cdd:PRK06814 737 rAFI-----------EKARlgPLIEALEFGIRIIY---LEDVRAQIGLADKIKGLLAGRFPlvyfcnrdpdDPAVILFTS 802
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 189 GTTGTPKLIPRTHDAYTYN-FVLSARLcAINTESVYLAVLPVAHNFILGSPGILGTLSqGGCVLLSDTascdeamPLiee 267
Cdd:PRK06814 803 GSEGTPKGVVLSHRNLLANrAQVAARI-DFSPEDKVFNALPVFHSFGLTGGLVLPLLS-GVKVFLYPS-------PL--- 870
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 268 hkvtHLALVPALAR-------------LWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFG---TAE 330
Cdd:PRK06814 871 ----HYRIIPELIYdtnatilfgtdtfLNGYARYAHPYDFRSLRYVFAGAEKVKEETRQTWMEKFGiRILEGYGvteTAP 946
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 331 GLLCYTrlddPYEVIINTQGRPLSeedeinLADTNLQPVAP-SEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGD 409
Cdd:PRK06814 947 VIALNT----PMHNKAGTVGRLLP------GIEYRLEPVPGiDEGGRLFVRGPNVMLGYLRAENPGVLEPPADGWYDTGD 1016
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 410 LVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQ-HPDiDDTVVIAVPDELLGERICACLPKSInqPDPAQMQAFL 488
Cdd:PRK06814 1017 IVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEELAAElWPD-ALHAAVSIPDARKGERIILLTTASD--ATRAAFLAHA 1093
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 2740590833 489 HQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENTETAE 534
Cdd:PRK06814 1094 KAAGASELMVPAEIITIDEIPLLGTGKIDYVAVTKLAEEAAAKPEA 1139
|
|
| FATP_FACS |
cd05940 |
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ... |
45-460 |
1.34e-18 |
|
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 89.72 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 45 EQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHD-VHALcQIARPvay 123
Cdd:cd05940 1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESlAHCL-NVSSA--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 124 iipdcihgfdyremarevaascpelEHIIVdgeaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKLIPRTHDA 203
Cdd:cd05940 77 -------------------------KHLVV--------------------------DAALYIYTSGTTGLPKAAIISHRR 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 204 YTYNFVLSARLCAINTESVYLAVLPVAHNfILGSPGILGTLSQGGCVLLSDTASCDEAMPLIEEHKVTHLALVPALAR-L 282
Cdd:cd05940 106 AWRGGAFFAGSGGALPSDVLYTCLPLYHS-TALIVGWSACLASGATLVIRKKFSASNFWDDIRKYQATIFQYIGELCRyL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 283 WEQARDWEQSDlSSLRClqVGGGRLTPELAEQVMARLGPLQ--QVFGTAEGLLCYTRLDDpyevIINTQGR--------- 351
Cdd:cd05940 185 LNQPPKPTERK-HKVRM--IFGNGLRPDIWEEFKERFGVPRiaEFYAATEGNSGFINFFG----KPGAIGRnpsllrkva 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 352 PLS------EEDE-INLADTNLQPVAPSEVGELITR--GPYTITGYYRAEQHNTVAFTT-----DGFYRTGDLVRIRPDG 417
Cdd:cd05940 258 PLAlvkydlESGEpIRDAEGRCIKVPRGEPGLLISRinPLEPFDGYTDPAATEKKILRDvfkkgDAWFNTGDLMRLDGEG 337
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 2740590833 418 NLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVP 460
Cdd:cd05940 338 FWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQ 380
|
|
| PRK13390 |
PRK13390 |
acyl-CoA synthetase; Provisional |
37-521 |
1.93e-18 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 89.68 E-value: 1.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 37 NKTALIYHE--QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGahpvlLMPTQRAHDVhal 114
Cdd:PRK13390 12 DRPAVIVAEtgEQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRSG-----LYITAINHHL--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 cqIARPVAYIIPDC-----IHGFDYREMAREVAASCPEleHIIVDGEAEEFIPFASiedePLNIIGPGYGDI---AVLLL 186
Cdd:PRK13390 84 --TAPEADYIVGDSgarvlVASAALDGLAAKVGADLPL--RLSFGGEIDGFGSFEA----ALAGAGPRLTEQpcgAVMLY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 187 SGGTTGTPK-----LIPRTHDAYTYNFVLSAR-LCAINTESVYLAVLPVAHNFILGSPGILGTLsqGGCVLLSDTASCDE 260
Cdd:PRK13390 156 SSGTTGFPKgiqpdLPGRDVDAPGDPIVAIARaFYDISESDIYYSSAPIYHAAPLRWCSMVHAL--GGTVVLAKRFDAQA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 261 AMPLIEEHKVTHLALVPA----LARLWEQARdwEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEGLLCYT 336
Cdd:PRK13390 234 TLGHVERYRITVTQMVPTmfvrLLKLDADVR--TRYDVSSLRAVIHAAAPCPVDVKHAMIDWLGPIVYEYYSSTEAHGMT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 337 RLDDP-YEVIINTQGRplSEEDEINLADTNLQPVAPSEVGELI---TRGPYTitgYYRAEQHNTVA-FTTDGFYRT-GDL 410
Cdd:PRK13390 312 FIDSPdWLAHPGSVGR--SVLGDLHICDDDGNELPAGRIGTVYferDRLPFR---YLNDPEKTAAAqHPAHPFWTTvGDL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 411 VRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICAC--LPKSINQPDPAQMQAFL 488
Cdd:PRK13390 387 GSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAViqLVEGIRGSDELARELID 466
|
490 500 510
....*....|....*....|....*....|....
gi 2740590833 489 HQKG-VQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK13390 467 YTRSrIAHYKAPRSVEFVDELPRTPTGKLVKGLL 500
|
|
| LC_FACS_bac |
cd05932 |
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ... |
46-457 |
2.33e-18 |
|
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 89.45 E-value: 2.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDV-----HALCQIarp 120
Cdd:cd05932 5 VEFTWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIryvleHSESKA--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 121 vayiipdCIHGF--DYREMAREVAASCPELEHIIVDgEAEEFIPFASI-------EDEPLniigPGYGDIAVLLLSGGTT 191
Cdd:cd05932 82 -------LFVGKldDWKAMAPGVPEGLISISLPPPS-AANCQYQWDDLiaqhpplEERPT----RFPEQLATLIYTSGTT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 192 GTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAH----NFILGSPGILGTLsqggcvlLSDTASCDEAMPLIEE 267
Cdd:cd05932 150 GQPKGVMLTFGSFAWAAQAGIEHIGTEENDRMLSYLPLAHvterVFVEGGSLYGGVL-------VAFAESLDTFVEDVQR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 268 HKVTHLALVPalaRLWEQARDWEQSD----------------------------LSSLRCLQVGGGRLTPELAEQvMARL 319
Cdd:cd05932 223 ARPTLFFSVP---RLWTKFQQGVQDKipqqklnlllkipvvnslvkrkvlkglgLDQCRLAGCGSAPVPPALLEW-YRSL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 320 G-PLQQVFGTAEGLlCYTRLDDPYEVIINTQGRPLSE-EDEInladtnlqpvapSEVGELITRGPYTITGYYRAEQHNTV 397
Cdd:cd05932 299 GlNILEAYGMTENF-AYSHLNYPGRDKIGTVGNAGPGvEVRI------------SEDGEILVRSPALMMGYYKDPEATAE 365
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2740590833 398 AFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRS-GEKISTLEVETLLLQHPDIDDTVVI 457
Cdd:cd05932 366 AFTADGFLRTGDKGELDADGNLTITGRVKDIFKTSkGKYVAPAPIENKLAEHDRVEMVCVI 426
|
|
| PRK08308 |
PRK08308 |
acyl-CoA synthetase; Validated |
110-521 |
3.70e-18 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 88.17 E-value: 3.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 110 DVHALCQIARPV-AYIIPdcIHGFDYREMAREVA--ASCpeleHIIVDGEAEEFIpfasIEDEPLNIIGPGygdiaVLLL 186
Cdd:PRK08308 44 DIITLVFFLKEKgASVLP--IHPDTPKEAAIRMAkrAGC----HGLLYGESDFTK----LEAVNYLAEEPS-----LLQY 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 187 SGGTTGTPKLIPRTH-------DAYTYNFVlsarlCAINTESVYLAvlPVAHNFILGSpGILGTLSQGGCVLLSDTASCD 259
Cdd:PRK08308 109 SSGTTGEPKLIRRSWteidreiEAYNEALN-----CEQDETPIVAC--PVTHSYGLIC-GVLAALTRGSKPVIITNKNPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 260 EAMPLIEEHKVtHL-----ALVPALARLweqARDWEQsdlssLRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEG--- 331
Cdd:PRK08308 181 FALNILRNTPQ-HIlyavpLMLHILGRL---LPGTFQ-----FHAVMTSGTPLPEAWFYKLRERTTYMMQQYGCSEAgcv 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 332 LLCYTrLDDPYEViintqGRPLSEEDeinlADTNLQPVAPSEVgeLITRGPYTItgyyraeqhntvafttdgfyRTGDLV 411
Cdd:PRK08308 252 SICPD-MKSHLDL-----GNPLPHVS----VSAGSDENAPEEI--VVKMGDKEI--------------------FTKDLG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 412 RIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICAcLPKSINQPDPAQMQAFLhQK 491
Cdd:PRK08308 300 YKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKA-KVISHEEIDPVQLREWC-IQ 377
|
410 420 430
....*....|....*....|....*....|
gi 2740590833 492 GVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK08308 378 HLAPYQVPHEIESVTEIPKNANGKVSRKLL 407
|
|
| pabB |
PRK15465 |
aminodeoxychorismate synthase component 1; |
744-977 |
4.78e-18 |
|
aminodeoxychorismate synthase component 1;
Pssm-ID: 185362 [Multi-domain] Cd Length: 453 Bit Score: 88.05 E-value: 4.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 744 QVELGSNIDITHS--YWLG----RQANTPARSFFLRDGDFSAYGFSPETVVEAEgSGWINTQPLAGTRALTHDKKQDQQL 817
Cdd:PRK15465 211 QVNLAQRFHATYSgdEWQAflqlNQANRAPFSAFLRLEQGAILSLSPERFILCD-NSEIQTRPIKGTLPRLPDPQEDSKQ 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 818 RADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHLASRVKGLLHTDKNRWDAFIALFPAVTASG 897
Cdd:PRK15465 290 AEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITG 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 898 IPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAGAGLVRNSRPEREWQETCEKLECIMK 977
Cdd:PRK15465 370 APKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDKVNRILR 449
|
|
| PRK12492 |
PRK12492 |
long-chain-fatty-acid--CoA ligase; Provisional |
48-525 |
1.06e-17 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 87.96 E-value: 1.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGL-YHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHD---------VHALCQI 117
Cdd:PRK12492 50 LSYAELERHSAAFAAYLqQHTDLVPGDRIAVQMPNVLQYPIAVFGALRAGLIVVNTNPLYTAREmrhqfkdsgARALVYL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 ---ARPVAYIIPDCihGFDY---REMAREVAASCPELEHIIVDGEAE--------EFIPFASI----EDEPLNIIGPGYG 179
Cdd:PRK12492 130 nmfGKLVQEVLPDT--GIEYlieAKMGDLLPAAKGWLVNTVVDKVKKmvpayhlpQAVPFKQAlrqgRGLSLKPVPVGLD 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNfVLSARLCAINT-----------ESVYLAVLPVAHNFILGSPGILGTLSQGG 248
Cdd:PRK12492 208 DIAVLQYTGGTTGLAKGAMLTHGNLVAN-MLQVRACLSQLgpdgqplmkegQEVMIAPLPLYHIYAFTANCMCMMVSGNH 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 249 CVLLSDTASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFG 327
Cdd:PRK12492 287 NVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALMDHPGFKDLDFSALKLTNSGGTALVKATAERWEQLTGcTIVEGYG 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 328 TAEGLLCYTRldDPYEVI--INTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFY 405
Cdd:PRK12492 367 LTETSPVAST--NPYGELarLGTVGIPVPGT-ALKVIDDDGNELPLGERGELCIKGPQVMKGYWQQPEATAEALDAEGWF 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 406 RTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQ 485
Cdd:PRK12492 444 KTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVVMAHPKVANCAAIGVPDERSGEAVKLFVVARDPGLSVEELK 523
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 2740590833 486 AFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMA 525
Cdd:PRK12492 524 AYC-KENFTGYKVPKHIVLRDSLPMTPVGKILRRELRDIA 562
|
|
| PRK07445 |
PRK07445 |
O-succinylbenzoic acid--CoA ligase; Reviewed |
273-527 |
1.70e-17 |
|
O-succinylbenzoic acid--CoA ligase; Reviewed
Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 86.59 E-value: 1.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVPA-LARLWEQARDWeqsdLSSLRCLQVGGGRLTPELAEQVmARLG-PLQQVFGTAE--GLLCYTRLDDPYEVIINT 348
Cdd:PRK07445 211 LSLVPTqLQRLLQLRPQW----LAQFRTILLGGAPAWPSLLEQA-RQLQlRLAPTYGMTEtaSQIATLKPDDFLAGNNSS 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 349 qGRPLSEedeinladTNLQpVAPSEVGELITRGPYTITGYYraeQHNtvaFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQ 428
Cdd:PRK07445 286 -GQVLPH--------AQIT-IPANQTGNITIQAQSLALGYY---PQI---LDSQGIFETDDLGYLDAQGYLHILGRNSQK 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 429 INRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVAYW 508
Cdd:PRK07445 350 IITGGENVYPAEVEAAILATGLVQDVCVLGLPDPHWGEVVTAIYVPKDPSISLEELKTAIKDQ-LSPFKQPKHWIPVPQL 428
|
250
....*....|....*....
gi 2740590833 509 PLTAVGKINKRQLVQMAQA 527
Cdd:PRK07445 429 PRNPQGKINRQQLQQIAVQ 447
|
|
| PRK00174 |
PRK00174 |
acetyl-CoA synthetase; Provisional |
15-541 |
4.91e-17 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 85.96 E-value: 4.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 15 PNYLW--NGKT------LDQQLAGWssiwGNKTALI------YHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLP 80
Cdd:PRK00174 56 PFIKWfeDGELnvsyncLDRHLKTR----GDKVAIIwegddpGDSRKITYRELHREVCRFANALKSLGVKKGDRVAIYMP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 81 NRISFVVTCFALFRLGAhpvllmptqrAHDV-------HAL------CQiARPVayIIPDcihGFdYR--------EMAR 139
Cdd:PRK00174 132 MIPEAAVAMLACARIGA----------VHSVvfggfsaEALadriidAG-AKLV--ITAD---EG-VRggkpiplkANVD 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 140 EVAASCPELEHIIV---DGEA-----------EEFIPFAS--IEDEPLNIIGPGYgdiavLLLSGGTTGTPKLIPRT--- 200
Cdd:PRK00174 195 EALANCPSVEKVIVvrrTGGDvdwvegrdlwwHELVAGASdeCEPEPMDAEDPLF-----ILYTSGSTGKPKGVLHTtgg 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 201 ---HDAYTYNFVLSarlcaINTESVYLAVLPV----AHNFIlgspgILGTLSQGGCVLL-------SDTASCDEampLIE 266
Cdd:PRK00174 270 ylvYAAMTMKYVFD-----YKDGDVYWCTADVgwvtGHSYI-----VYGPLANGATTLMfegvpnyPDPGRFWE---VID 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 267 EHKVTHLALVPALAR-LWEQARDW-EQSDLSSLRCL-----------------QVGGGR----------------LTPel 311
Cdd:PRK00174 337 KHKVTIFYTAPTAIRaLMKEGDEHpKKYDLSSLRLLgsvgepinpeawewyykVVGGERcpivdtwwqtetggimITP-- 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 312 aeqvmarL-GPLQQVFGTAegllcyTRlddPY----EVIINTQGRPLSEEDEINLAdtnlqpvapsevgelITRgPY--- 383
Cdd:PRK00174 415 -------LpGATPLKPGSA------TR---PLpgiqPAVVDEEGNPLEGGEGGNLV---------------IKD-PWpgm 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 384 --TITG--------YYRAEqhntvafttDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDD 453
Cdd:PRK00174 463 mrTIYGdherfvktYFSTF---------KGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAE 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 454 TVVIAVPDELLGERICA-CLPKSINQPDPAqmqafLHQKGVQ--RHKI-----PDQWLFVAYWPLTAVGKINKRQLVQMA 525
Cdd:PRK00174 534 AAVVGRPDDIKGQGIYAfVTLKGGEEPSDE-----LRKELRNwvRKEIgpiakPDVIQFAPGLPKTRSGKIMRRILRKIA 608
|
650 660
....*....|....*....|
gi 2740590833 526 QAE----NTETAENNSLMKQ 541
Cdd:PRK00174 609 EGEeilgDTSTLADPSVVEK 628
|
|
| entF |
PRK10252 |
enterobactin non-ribosomal peptide synthetase EntF; |
40-521 |
7.32e-17 |
|
enterobactin non-ribosomal peptide synthetase EntF;
Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 86.25 E-value: 7.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIAR 119
Cdd:PRK10252 476 ALADARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDAR 555
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 120 PVAYIipdcihgfdyremarEVAASCPELEHIIVDGEAEEFIPFASIEDEPLNIIGPGygDIAVLLLSGGTTGTPKLIPR 199
Cdd:PRK10252 556 PSLLI---------------TTADQLPRFADVPDLTSLCYNAPLAPQGAAPLQLSQPH--HTAYIIFTSGSTGRPKGVMV 618
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 THDAYT---------YNF-----VLSARLCAINTeSVYLAVLPvahnFILGSpgilgTLsqggcVLLSDTASCD-EAMP- 263
Cdd:PRK10252 619 GQTAIVnrllwmqnhYPLtaddvVLQKTPCSFDV-SVWEFFWP----FIAGA-----KL-----VMAEPEAHRDpLAMQq 683
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 264 LIEEHKVTHLALVPALarlweqardweqsdlsslrcLQVGGGRLTPELAEQVMArlgPLQQVFGTAEGL---LC---YTR 337
Cdd:PRK10252 684 FFAEYGVTTTHFVPSM--------------------LAAFVASLTPEGARQSCA---SLRQVFCSGEALpadLCrewQQL 740
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 338 -------LDDPYEVIINTQGRPLSEEDEINLA------------------DTNLQPVAPSEVGELITRGPYTITGYYRAE 392
Cdd:PRK10252 741 tgaplhnLYGPTEAAVDVSWYPAFGEELAAVRgssvpigypvwntglrilDARMRPVPPGVAGDLYLTGIQLAQGYLGRP 820
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 393 QHNTVAFTTDGF------YRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAV----PDE 462
Cdd:PRK10252 821 DLTASRFIADPFapgermYRTGDVARWLDDGAVEYLGRSDDQLKIRGQRIELGEIDRAMQALPDVEQAVTHACvinqAAA 900
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 463 LLGE--RICACLPKSINQP-DPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK10252 901 TGGDarQLVGYLVSQSGLPlDTSALQAQL-RERLPPHMVPVVLLQLDQLPLSANGKLDRKAL 961
|
|
| PRK08974 |
PRK08974 |
long-chain-fatty-acid--CoA ligase FadD; |
180-521 |
2.26e-16 |
|
long-chain-fatty-acid--CoA ligase FadD;
Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 83.56 E-value: 2.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNfVLSAR-----LCAINTESVYLAvLPVAHNFILGSPGILgTLSQGGC-VLLS 253
Cdd:PRK08974 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAN-LEQAKaaygpLLHPGKELVVTA-LPLYHIFALTVNCLL-FIELGGQnLLIT 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 254 DTASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRcLQVGGGrltpelaeqvMArlgpLQQVFGTAEGLL 333
Cdd:PRK08974 284 NPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQELDFSSLK-LSVGGG----------MA----VQQAVAERWVKL 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 334 CYTRLDD--------------PYEVIINTQ--GRPLSEEDeINLADTNLQPVAPSEVGELITRGPYTITGYY-RAEQhnT 396
Cdd:PRK08974 349 TGQYLLEgygltecsplvsvnPYDLDYYSGsiGLPVPSTE-IKLVDDDGNEVPPGEPGELWVKGPQVMLGYWqRPEA--T 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 397 VAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACLPKSi 476
Cdd:PRK08974 426 DEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKVLEVAAVGVPSEVSGEAVKIFVVKK- 504
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2740590833 477 nqpDPAQMQAFLhQKGVQRH----KIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK08974 505 ---DPSLTEEEL-ITHCRRHltgyKVPKLVEFRDELPKSNVGKILRREL 549
|
|
| PRK07514 |
PRK07514 |
malonyl-CoA synthase; Validated |
46-518 |
3.07e-16 |
|
malonyl-CoA synthase; Validated
Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 83.00 E-value: 3.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpVLLmPTQRAHDVHALcqiarpvAYII 125
Cdd:PRK07514 27 LRYTYGDLDAASARLANLLVALGVKPGDRVAVQVEKSPEALALYLATLRAGA--VFL-PLNTAYTLAEL-------DYFI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 PD-------CIHGfdYREMAREVAASC--PELEHIIVDGEAEeFIPFASIEDEPLNIIGPGYGDIAVLLLSGGTTGTPKL 196
Cdd:PRK07514 97 GDaepalvvCDPA--NFAWLSKIAAAAgaPHVETLDADGTGS-LLEAAAAAPDDFETVPRGADDLAAILYTSGTTGRSKG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 197 IPRTHDAYTYNFVLSARLCAINTESVYLAVLPV--AHNFILGSPGILgtLSQGGCVLLS--DTASCDEAMPlieehKVTH 272
Cdd:PRK07514 174 AMLSHGNLLSNALTLVDYWRFTPDDVLIHALPIfhTHGLFVATNVAL--LAGASMIFLPkfDPDAVLALMP-----RATV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 273 LALVPAL-ARLWEQARdWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEGLLCYTrldDPY--EVIINT 348
Cdd:PRK07514 247 MMGVPTFyTRLLQEPR-LTREAAAHMRLFISGSAPLLAETHREFQERTGhAILERYGMTETNMNTS---NPYdgERRAGT 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 349 QGRPLSEEdEINLAD-TNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKE 427
Cdd:PRK07514 323 VGFPLPGV-SLRVTDpETGAELPPGEIGMIEVKGPNVFKGYWRMPEKTAEEFRADGFFITGDLGKIDERGYVHIVGRGKD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 428 QINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLHQKgVQRHKIPDQWLFVA 506
Cdd:PRK07514 402 LIISGGYNVYPKEVEGEIDELPGVVESAVIGVPHPDFGEGVTAVVvPKPGAALDEAAILAALKGR-LARFKQPKRVFFVD 480
|
490
....*....|..
gi 2740590833 507 YWPLTAVGKINK 518
Cdd:PRK07514 481 ELPRNTMGKVQK 492
|
|
| FCS |
cd05921 |
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ... |
47-461 |
6.12e-16 |
|
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.
Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 82.09 E-value: 6.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLG--AHPVLLMPTQRAHDVHALCQIarpVAYI 124
Cdd:cd05921 25 RVTYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGvpAAPVSPAYSLMSQDLAKLKHL---FELL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 125 IPDCIHGFDYREMAREVAASCP---ELEHIIVDGEAEEFIPFASI--------EDEPLNIIGPgyGDIAVLLLSGGTTGT 193
Cdd:cd05921 102 KPGLVFAQDAAPFARALAAIFPlgtPLVVSRNAVAGRGAISFAELaatpptaaVDAAFAAVGP--DTVAKFLFTSGSTGL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 194 PKLIPRTHDAYTYNFVLSARLCAINTES--VYLAVLPVAHNFIlGSPGILGTLSQGGcvllsdTASCDEAMPL------- 264
Cdd:cd05921 180 PKAVINTQRMLCANQAMLEQTYPFFGEEppVLVDWLPWNHTFG-GNHNFNLVLYNGG------TLYIDDGKPMpggfeet 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 265 ---IEEHKVTHLALVPA----LARLWEQARDWEQSDLSSLRCLQVGGGRLTP-------ELAEQVMARLGPLQQVFGTAE 330
Cdd:cd05921 253 lrnLREISPTVYFNVPAgwemLVAALEKDEALRRRFFKRLKLMFYAGAGLSQdvwdrlqALAVATVGERIPMMAGLGATE 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 331 ----GLLCYTRLDDPYEVIINTQGrplseedeinladTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYR 406
Cdd:cd05921 333 taptATFTHWPTERSGLIGLPAPG-------------TELKLVPSGGKYEVRVKGPNVTPGYWRQPELTAQAFDEEGFYC 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 407 TGDLVRI----RPDGNLLVEGRIKEQIN-RSGEKIS--TLEVETLLLQHPDIDDtVVIAVPD 461
Cdd:cd05921 400 LGDAAKLadpdDPAKGLVFDGRVAEDFKlASGTWVSvgPLRARAVAACAPLVHD-AVVAGED 460
|
|
| PRK07768 |
PRK07768 |
long-chain-fatty-acid--CoA ligase; Validated |
47-442 |
1.41e-15 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 80.81 E-value: 1.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 47 RLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL-MPTQRAHDVHALCQIARPVAYIi 125
Cdd:PRK07768 29 RHTWGEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRGASLTMLhQPTPRTDLAVWAEDTLRVIGMI- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 pdcihgfdyreMAREVAASCPELEHI-IVDGEAEEFIPFASIED-EPLNIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDa 203
Cdd:PRK07768 108 -----------GAKAVVVGEPFLAAApVLEEKGIRVLTVADLLAaDPIDPVETGEDDLALMQLTSGSTGSPKAVQITHG- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 204 ytyNFVLSARL----CAINTES-VYLAVLPVAHNfiLGSPGILGTLSQGGCVL--------LSDTASCdeaMPLIEEHKV 270
Cdd:PRK07768 176 ---NLYANAEAmfvaAEFDVETdVMVSWLPLFHD--MGMVGFLTVPMYFGAELvkvtpmdfLRDPLLW---AELISKYRG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 271 THLAlVPALA------RLWEQARDwEQSDLSSLRCLQVGGGRLTPELAEQVM---ARLG----PLQQVFGTAEGLLC--Y 335
Cdd:PRK07768 248 TMTA-APNFAyallarRLRRQAKP-GAFDLSSLRFALNGAEPIDPADVEDLLdagARFGlrpeAILPAYGMAEATLAvsF 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 336 TRLDDPYEVII------------------NTQ-----GRPLSEEdEINLADTNLQPVAPSEVGELITRGPyTITGYYRAE 392
Cdd:PRK07768 326 SPCGAGLVVDEvdadllaalrravpatkgNTRrlatlGPPLPGL-EVRVVDEDGQVLPPRGVGVIELRGE-SVTPGYLTM 403
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 2740590833 393 QHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVE 442
Cdd:PRK07768 404 DGFIPAQDADGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIE 453
|
|
| PRK15012 |
PRK15012 |
menaquinone-specific isochorismate synthase; Provisional |
724-967 |
1.46e-15 |
|
menaquinone-specific isochorismate synthase; Provisional
Pssm-ID: 184974 [Multi-domain] Cd Length: 431 Bit Score: 80.27 E-value: 1.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 724 VANAVKDIASGHYQKVILSRQVEL--GSNIDITHSYWLGRQANTPARSFFLR-DGDFSAYGFSPETVVEAEGSGwINTQP 800
Cdd:PRK15012 176 IELATKTIAEGELDKVVLARATDLhfASPVNAAAMMAASRRLNLNCYHFYMAfDAENAFLGSSPERLWRRRDKA-LRTEA 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 801 LAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKlaleelaPICQ-----PETLCVSEFMAICERgSVQHLasrvKGL 875
Cdd:PRK15012 255 LAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE-------DICQrlqadTQTLDVLPPQVLRLR-KVQHL----RRC 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 876 LHTDKNRWDAFIALF---PAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLdSTGKLDAALVLRSLYQHKERCWLQAG 952
Cdd:PRK15012 323 IWTSLNKADDVICLHqlqPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYL-SLQQSEFCVSLRSAKVSGNVVRLYAG 401
|
250
....*....|....*
gi 2740590833 953 AGLVRNSRPEREWQE 967
Cdd:PRK15012 402 AGIVRGSDPEQEWQE 416
|
|
| A_NRPS_MycA_like |
cd05908 |
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ... |
181-526 |
1.66e-15 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 80.61 E-value: 1.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 181 IAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSpGILGTLSQGGCVLLSDTASCDE 260
Cdd:cd05908 108 LAFIQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKDRILSWMPLTHDMGLIA-FHLAPLIAGMNQYLMPTRLFIR 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 261 A----MPLIEEHKVTHLAlVPALARLW-------EQARDWeqsDLSSLRCLQVGGGRLTPELAEQVMARLGP-------L 322
Cdd:cd05908 187 RpilwLKKASEHKATIVS-SPNFGYKYflktlkpEKANDW---DLSSIRMILNGAEPIDYELCHEFLDHMSKyglkrnaI 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 323 QQVFGTAEGLL--CYTRLDDPYEVIIN-----TQGRPLSEED-------------------EINLADTNLQPVAPSEVGE 376
Cdd:cd05908 263 LPVYGLAEASVgaSLPKAQSPFKTITLgrrhvTHGEPEPEVDkkdsecltfvevgkpidetDIRICDEDNKILPDGYIGH 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 377 LITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRpDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDID--DT 454
Cdd:cd05908 343 IQIRGKNVTPGYYNNPEATAKVFTDDGWLKTGDLGFIR-NGRLVITGREKDIIFVNGQNVYPHDIERIAEELEGVElgRV 421
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 455 VVIAVPDELLGERICACL---PKSINQ--PDPAQMQAFLHQ-KGVQRHKIpdqwLFVAYWPLTAVGKINKRQLVQMAQ 526
Cdd:cd05908 422 VACGVNNSNTRNEEIFCFiehRKSEDDfyPLGKKIKKHLNKrGGWQINEV----LPIRRIPKTTSGKVKRYELAQRYQ 495
|
|
| PRK15016 |
PRK15016 |
isochorismate synthase EntC; Provisional |
724-972 |
2.12e-15 |
|
isochorismate synthase EntC; Provisional
Pssm-ID: 184977 [Multi-domain] Cd Length: 391 Bit Score: 79.53 E-value: 2.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 724 VANAVKDIASGHYQKVILSRQVELGSNIDITHSYWLGRQ-ANTPARSFF---LRDGDfSAYGFSPETVVEAEGSGWiNTQ 799
Cdd:PRK15016 133 VARAAALTATPQVDKVVLSRLIDITTDAAIDSGALLERLiAQNPVSYNFhvpLADGG-VLLGASPELLLRKDGERF-SSL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 800 PLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPicQPETLCVSEFMAICERGSVQHLASRVKGLLHTD 879
Cdd:PRK15016 211 PLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRE--RSSELHVPSSPQLITTPTLWHLATPFEGKANAQ 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 880 KNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAGAGLVRNS 959
Cdd:PRK15016 289 ENALTLACLLHPTPALSGFPHQAAKQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPAS 368
|
250
....*....|...
gi 2740590833 960 RPEREWQETCEKL 972
Cdd:PRK15016 369 SPLGEWRETGVKL 381
|
|
| AACS |
cd05943 |
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ... |
40-535 |
2.21e-15 |
|
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.
Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 80.78 E-value: 2.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 40 ALIYHE-----QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHA- 113
Cdd:cd05943 86 AAIYAAedgerTEVTWAELRRRVARLAAALRALGVKPGDRVAGYLPNIPEAVVAMLATASIGAIWSSCSPDFGVPGVLDr 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 114 LCQIARPV-----AYIIPDCIHgfDYREMAREVAASCPELEHIIV----------DGEA-------EEFI---PFASIED 168
Cdd:cd05943 166 FGQIEPKVlfavdAYTYNGKRH--DVREKVAELVKGLPSLLAVVVvpytvaagqpDLSKiakaltlEDFLatgAAGELEF 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 169 EPLNIIGPGYgdiavLLLSGGTTGTPKLIprTHDA-------------------------YT------YNFVLSArlcai 217
Cdd:cd05943 244 EPLPFDHPLY-----ILYSSGTTGLPKCI--VHGAggtllqhlkehilhcdlrpgdrlfyYTtcgwmmWNWLVSG----- 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 218 ntesvyLAVlpvahnfilgspgilgtlsqGGCVLLSD---TASCDEAMP-LIEEHKVTHL----ALVPALARLWEQARdw 289
Cdd:cd05943 312 ------LAV--------------------GATIVLYDgspFYPDTNALWdLADEEGITVFgtsaKYLDALEKAGLKPA-- 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 290 EQSDLSSLRCLQVGGGRLTPELAEQVMARLGP---LQQVFGTAEGLLCY---TRLDDPYEVIIntQGRPLSEEDEInlAD 363
Cdd:cd05943 364 ETHDLSSLRTILSTGSPLKPESFDYVYDHIKPdvlLASISGGTDIISCFvggNPLLPVYRGEI--QCRGLGMAVEA--FD 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 364 TNLQPVaPSEVGEL-ITRG-PYTITGY--------YRA---EQHNtvafttdGFYRTGDLVRIRPDGNLLVEGRIKEQIN 430
Cdd:cd05943 440 EEGKPV-WGEKGELvCTKPfPSMPVGFwndpdgsrYRAayfAKYP-------GVWAHGDWIEITPRGGVVILGRSDGTLN 511
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 431 RSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERIC--------ACLPKSINQpdpaQMQAFLHQKGVQRHkIPDQW 502
Cdd:cd05943 512 PGGVRIGTAEIYRVVEKIPEVEDSLVVGQEWKDGDERVIlfvklregVELDDELRK----RIRSTIRSALSPRH-VPAKI 586
|
570 580 590
....*....|....*....|....*....|....*.
gi 2740590833 503 LFVAYWPLTAVGKINK---RQLVQMAQAENTETAEN 535
Cdd:cd05943 587 IAVPDIPRTLSGKKVEvavKKIIAGRPVKNAGALAN 622
|
|
| FATP_chFAT1_like |
cd05937 |
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ... |
43-459 |
2.63e-15 |
|
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.
Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 79.78 E-value: 2.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 43 YHEQRLTYHELHQSAERLANGLY-HRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLL-MPTQRAHDVHALcQIARp 120
Cdd:cd05937 1 FEGKTWTYSETYDLVLRYAHWLHdDLGVQAGDFVAIDLTNSPEFVFLWLGLWSIGAAPAFInYNLSGDPLIHCL-KLSG- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 121 vayiipdcihgfdyremAREVaascpelehiIVDGEaeefipfasiedeplniigpgygDIAVLLLSGGTTGTPKLIP-R 199
Cdd:cd05937 79 -----------------SRFV----------IVDPD-----------------------DPAILIYTSGTTGLPKAAAiS 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 THDAYTYNFVLSARLCAINTESVYLAvLPVAHnfilGSPGILGT---LSQGGCVLLSDTASCDEAMPLIEEHKVTHLALV 276
Cdd:cd05937 109 WRRTLVTSNLLSHDLNLKNGDRTYTC-MPLYH----GTAAFLGAcncLMSGGTLALSRKFSASQFWKDVRDSGATIIQYV 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 277 PALAR--LWEQARDWEQSDlsslRCLQVGGGRLTPELAEQVMARLG--PLQQVFGTAEGLLCYTRL-------------- 338
Cdd:cd05937 184 GELCRylLSTPPSPYDRDH----KVRVAWGNGLRPDIWERFRERFNvpEIGEFYAATEGVFALTNHnvgdfgagaighhg 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 339 --------DDPYEVIINTQgrplsEEDEINLADTNLQPVAP-SEVGELITRGPY----TITGYYRAEQHNTVAFTTDGF- 404
Cdd:cd05937 260 lirrwkfeNQVVLVKMDPE-----TDDPIRDPKTGFCVRAPvGEPGEMLGRVPFknreAFQGYLHNEDATESKLVRDVFr 334
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 405 -----YRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAV 459
Cdd:cd05937 335 kgdiyFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYGV 394
|
|
| PRK07093 |
PRK07093 |
para-aminobenzoate synthase component I; Validated |
782-971 |
2.68e-15 |
|
para-aminobenzoate synthase component I; Validated
Pssm-ID: 235932 [Multi-domain] Cd Length: 323 Bit Score: 77.99 E-value: 2.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 782 FSPETVVEAEGsGWINTQPLAGT--RALTHDKKQdqqlradLLSDPKEISEHAVSVKLALEELAPICqpETLCVSEFMAI 859
Cdd:PRK07093 131 FSPEPFVRIED-NKISTYPMKGTidASLPNAEEK-------LLNDEKEFAEHATIVDLLRNDLSMVA--KNVRVTRFRYI 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 860 ----CERGSVQHLASRVKGLLHTD-KNRW-DAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGcVMLLDSTGKLDA 933
Cdd:PRK07093 201 dkikTNKGEILQTSSEISGTLPENwQENIgDILAKLLPAGSITGAPKEKTVEIIEQAEGYERGFYTG-VFGYFDGESLDS 279
|
170 180 190
....*....|....*....|....*....|....*...
gi 2740590833 934 ALVLRSLYQHKERCWLQAGAGLVRNSRPEREWQETCEK 971
Cdd:PRK07093 280 AVMIRFIEQENDGLYFKSGGGITIDSDLKDEYNELIQK 317
|
|
| PLN02889 |
PLN02889 |
oxo-acid-lyase/anthranilate synthase |
714-967 |
4.05e-15 |
|
oxo-acid-lyase/anthranilate synthase
Pssm-ID: 215481 [Multi-domain] Cd Length: 918 Bit Score: 80.28 E-value: 4.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 714 ADTAK-NYQDNVANAVKDIASGHYQKVILSRQV--ELGsNIDITHSYWLGRQANTPARSFFLR--DGDFSAYGFSPETVV 788
Cdd:PLN02889 639 ADKSReQYIKDVQKCLKYIKDGESYELCLTTQMrkRIG-EIDSLGLYLHLREKNPAPYAAWLNfsNENLCICSSSPERFL 717
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 789 EAEGSGWINTQPLAGTRALTHDKKQDQQLRADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHL 868
Cdd:PLN02889 718 KLDRNGMLEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVESYTTVHTM 797
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 869 ASRVKGLLHTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCW 948
Cdd:PLN02889 798 VSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGIYSGSIGFFSYNQTFDLNIVIRTVVIHEGEAS 877
|
250
....*....|....*....
gi 2740590833 949 LQAGAGLVRNSRPEREWQE 967
Cdd:PLN02889 878 IGAGGAIVALSNPEDEYEE 896
|
|
| PRK05877 |
PRK05877 |
aminodeoxychorismate synthase component I; Provisional |
722-981 |
4.63e-15 |
|
aminodeoxychorismate synthase component I; Provisional
Pssm-ID: 235634 [Multi-domain] Cd Length: 405 Bit Score: 78.59 E-value: 4.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 722 DNVANAVKDIASGH-YQKVILSR-QVEL-GSNIDithsYWLGRQANT-PARSFFLRdGDFSAYG-FSPETVVEAEGSGwI 796
Cdd:PRK05877 146 DGVLACLEAIAAGEvYQACVCTQfTGTVtGSPLD----FFADGVARTaPARAAYLA-GDWGAVAsLSPELFLRRRGSV-V 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 797 NTQPLAGTRALTHDKkqdqqlrADLLSDPKEISEHAVSVKLALEELAPICQPETLCVSEFMAICERGSVQHLASRVKGLL 876
Cdd:PRK05877 220 TSSPIKGTLPLDADP-------SALRASAKDVAENIMIVDLVRNDLGRVARTGTVTVPELLVVRPAPGVWHLVSTVSAQV 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 877 HTDKNRWDAFIALFPAVTASGIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSL-YQHKERCWLQAGAGL 955
Cdd:PRK05877 293 PDELPMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVeFDADGNAVLGVGGGI 372
|
250 260
....*....|....*....|....*.
gi 2740590833 956 VRNSRPEREWQETCEKLECIMKYVRP 981
Cdd:PRK05877 373 TADSDPDAEWQECLHKAAPIVGLPAA 398
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
180-527 |
1.18e-14 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 78.81 E-value: 1.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFilgspGILGT----LSQG-GCVLLSD 254
Cdd:PRK08633 783 DTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNLRNDDVILSSLPFFHSF-----GLTVTlwlpLLEGiKVVYHPD 857
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 255 TASCDEAMPLIEEHKVTHLALVPALARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG--PLQQvFGTAE-- 330
Cdd:PRK08633 858 PTDALGIAKLVAKHRATILLGTPTFLRLYLRNKKLHPLMFASLRLVVAGAEKLKPEVADAFEEKFGirILEG-YGATEts 936
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 331 ---GLLCYTRLDDPYEVIINTQ----GRPL---SeedeINLAD-TNLQPVAPSEVGELITRGPYTITGYY-RAEQHNTVA 398
Cdd:PRK08633 937 pvaSVNLPDVLAADFKRQTGSKegsvGMPLpgvA----VRIVDpETFEELPPGEDGLILIGGPQVMKGYLgDPEKTAEVI 1012
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 399 FTTDG--FYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQ--HPDIDDTVVIAVPDELLGERIcaCLPK 474
Cdd:PRK08633 1013 KDIDGigWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEELAKalGGEEVVFAVTAVPDEKKGEKL--VVLH 1090
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2740590833 475 SINQPDPAQMQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQA 527
Cdd:PRK08633 1091 TCGAEDVEELKRAIKESGLPNLWKPSRYFKVEALPLLGSGKLDLKGLKELALA 1143
|
|
| LC-FACS_euk |
cd05927 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ... |
48-462 |
1.52e-14 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.
Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 77.64 E-value: 1.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQL--PNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHalcqiarpvaYII 125
Cdd:cd05927 6 ISYKEVAERADNIGSALRSLGGKPAPASFVGIysINRPEWIISELACYAYSLVTVPLYDTLGPEAIE----------YIL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 PDCihgfdyremarevaascpELEHIIVDGEAEeFIPFASIEDE----PLNIIGPGYGDIAVLLLSGGTTGTPKLIPRTH 201
Cdd:cd05927 76 NHA------------------EISIVFCDAGVK-VYSLEEFEKLgkknKVPPPPPKPEDLATICYTSGTTGNPKGVMLTH 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 202 DAYTyNFVLSA-----RLCAINTESVYLAVLPVAHnfILGSPGILGTLSQGGCV---------LLSDtascdeamplIEE 267
Cdd:cd05927 137 GNIV-SNVAGVfkileILNKINPTDVYISYLPLAH--IFERVVEALFLYHGAKIgfysgdirlLLDD----------IKA 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 268 HKVTHLALVPalaRLWEQ----------------------ARDWEQSDLSS------------------------LRCLQ 301
Cdd:cd05927 204 LKPTVFPGVP---RVLNRiydkifnkvqakgplkrklfnfALNYKLAELRSgvvraspfwdklvfnkikqalggnVRLML 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 302 VGGGRLTPELAEQVMARLG-PLQQVFGTAEGLlCYTRLDDPYEVIINTQGRPLSEeDEINLADT---NLQPVAPSEVGEL 377
Cdd:cd05927 281 TGSAPLSPEVLEFLRVALGcPVLEGYGQTECT-AGATLTLPGDTSVGHVGGPLPC-AEVKLVDVpemNYDAKDPNPRGEV 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 378 ITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRS-GEKISTLEVETLLLQHPDIDDT-- 454
Cdd:cd05927 359 CIRGPNVFSGYYKDPEKTAEALDEDGWLHTGDIGEWLPNGTLKIIDRKKNIFKLSqGEYVAPEKIENIYARSPFVAQIfv 438
|
490
....*....|....*..
gi 2740590833 455 ---------VVIAVPDE 462
Cdd:cd05927 439 ygdslksflVAIVVPDP 455
|
|
| LC_FACS_bac1 |
cd17641 |
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ... |
46-469 |
4.09e-14 |
|
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 76.31 E-value: 4.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYII 125
Cdd:cd17641 10 QEFTWADYADRVRAFALGLLALGVGRGDVVAILGDNRPEWVWAELAAQAIGALSLGIYQDSMAEEVAYLLNYTGARVVIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 PDcihgfdyREMAR---EVAASCPELEHIIVDGEA-------EEFIPFASIEDE--PLNIIGPG----------YGDIAV 183
Cdd:cd17641 90 ED-------EEQVDkllEIADRIPSVRYVIYCDPRgmrkyddPRLISFEDVVALgrALDRRDPGlyerevaagkGEDVAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 184 LLLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVA----HNFILGSPgilgtLSQGGCVLLSDTAscD 259
Cdd:cd17641 163 LCTTSGTTGKPKLAMLSHGNFLGHCAAYLAADPLGPGDEYVSVLPLPwigeQMYSVGQA-----LVCGFIVNFPEEP--E 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 260 EAMPLIEEHKVTHLALVPalaRLWE------QARDWEQSDLSS-----------------LRCLQVG-GGRLTPELAEQV 315
Cdd:cd17641 236 TMMEDLREIGPTFVLLPP---RVWEgiaadvRARMMDATPFKRfmfelgmklglraldrgKRGRPVSlWLRLASWLADAL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 316 MAR--------------------LGP------------LQQVFGTAEGLLCYT--RLDDpyeVIINTQGRPLSEEDeinl 361
Cdd:cd17641 313 LFRplrdrlgfsrlrsaatggaaLGPdtfrffhaigvpLKQLYGQTELAGAYTvhRDGD---VDPDTVGVPFPGTE---- 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 362 adtnlqpVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRS-GEKISTLE 440
Cdd:cd17641 386 -------VRIDEVGEILVRSPGVFVGYYKNPEATAEDFDEDGWLHTGDAGYFKENGHLVVIDRAKDVGTTSdGTRFSPQF 458
|
490 500
....*....|....*....|....*....
gi 2740590833 441 VETLLLQHPDIDDTVVIAVPDELLGERIC 469
Cdd:cd17641 459 IENKLKFSPYIAEAVVLGAGRPYLTAFIC 487
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
262-521 |
6.20e-14 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 76.75 E-value: 6.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 262 MPLIEEHKVTHLALVPAL-ARLWEQardwEQSDLSSLRCLQVGGGRLTPELAEQVMAR---LGpLQQVFGTAEgllC--- 334
Cdd:PRK05691 3953 LAHVQAQGITVLESVPSLiQGMLAE----DRQALDGLRWMLPTGEAMPPELARQWLQRypqIG-LVNAYGPAE---Csdd 4024
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 --YTRLDdpyevIINTQGRPL-----SEEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF--- 404
Cdd:PRK05691 4025 vaFFRVD-----LASTRGSYLpigspTDNNRLYLLDEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAFVPHPFgap 4099
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 405 ----YRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVViAVPDELLGERICACLPKSinqpD 480
Cdd:PRK05691 4100 gerlYRTGDLARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVREAAV-AVQEGVNGKHLVGYLVPH----Q 4174
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2740590833 481 PAQMQAFLHQKGVQRHK-------IPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK05691 4175 TVLAQGALLERIKQRLRaelpdymVPLHWLWLDRLPLNANGKLDRKAL 4222
|
|
| AFD_CAR-like |
cd17632 |
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ... |
39-416 |
7.11e-14 |
|
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.
Pssm-ID: 341287 [Multi-domain] Cd Length: 588 Bit Score: 75.57 E-value: 7.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 39 TALIYHEQRLTYHELHQSAERLANGL-YHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVllmPTQRAHDVHALCQI 117
Cdd:cd17632 59 LRLLPRFETITYAELWERVGAVAAAHdPEQPVRPGDFVAVLGFTSPDYATVDLALTRLGAVSV---PLQAGASAAQLAPI 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 118 arpVAYIIPDCIH-GFDYREMAREVAASCPELEHIIV-DGE-----------------AEEFIPFASIED---------- 168
Cdd:cd17632 136 ---LAETEPRLLAvSAEHLDLAVEAVLEGGTPPRLVVfDHRpevdahraalesarerlAAVGIPVTTLTLiavrgrdlpp 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 169 EPLNIIGPGYGDIAVLLLSGGTTGTPKliprtHDAYTYNFVLSARLCAINTE------SVYLAVLPVAHnfILGSPGILG 242
Cdd:cd17632 213 APLFRPEPDDDPLALLIYTSGSTGTPK-----GAMYTERLVATFWLKVSSIQdirppaSITLNFMPMSH--IAGRISLYG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 243 TLSQGGC---VLLSDTASCDEAMPLIeehKVTHLALVPalaRLWEQARDWEQSDLSslRCLQVGGGRLTpeLAEQVMARL 319
Cdd:cd17632 286 TLARGGTayfAAASDMSTLFDDLALV---RPTELFLVP---RVCDMLFQRYQAELD--RRSVAGADAET--LAERVKAEL 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 320 ------GPLQ-QVFGTA----------EGLLcYTRLDDPY------EVIINTQ-GRP------LSEEDEINLADTNLqpv 369
Cdd:cd17632 356 rervlgGRLLaAVCGSAplsaemkafmESLL-DLDLHDGYgsteagAVILDGViVRPpvldykLVDVPELGYFRTDR--- 431
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2740590833 370 aPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLV-RIRPD 416
Cdd:cd17632 432 -PHPRGELLVKTDTLFPGYYKRPEVTAEVFDEDGFYRTGDVMaELGPD 478
|
|
| PRK12582 |
PRK12582 |
acyl-CoA synthetase; Provisional |
48-427 |
1.41e-13 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 74.70 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFvvtcfALFRLGAH-------PVL----LMPT--QRAHDVHAL 114
Cdd:PRK12582 81 VTYGEAKRAVDALAQALLDLGLDPGRPVMILSGNSIEH-----ALMTLAAMqagvpaaPVSpaysLMSHdhAKLKHLFDL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 CqiaRPvAYIIPDciHGFDYREMAREVAASCPELEHIIVDGEAEEFIPFASIEDEPLN------IIGPGYGDIAVLLLSG 188
Cdd:PRK12582 156 V---KP-RVVFAQ--SGAPFARALAALDLLDVTVVHVTGPGEGIASIAFADLAATPPTaavaaaIAAITPDTVAKYLFTS 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 189 GTTGTPKLIPRTHDAYTYNFVLSA--RLCAINTE-SVYLAVLPVAHNFiLGSPGILGTLSQGGCVLLsdtascDEAMPL- 264
Cdd:PRK12582 230 GSTGMPKAVINTQRMMCANIAMQEqlRPREPDPPpPVSLDWMPWNHTM-GGNANFNGLLWGGGTLYI------DDGKPLp 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 265 --IEE-----HKV--THLALVPA----LARLWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMA--------RLgPLQ 323
Cdd:PRK12582 303 gmFEEtirnlREIspTVYGNVPAgyamLAEAMEKDDALRRSFFKNLRLMAYGGATLSDDLYERMQAlavrttghRI-PFY 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 324 QVFGTAE--GLLCYTRLDDPYEVIIntqGRPLSeedEINLadtNLQPVapSEVGELITRGPYTITGYYRAEQHNTVAFTT 401
Cdd:PRK12582 382 TGYGATEtaPTTTGTHWDTERVGLI---GLPLP---GVEL---KLAPV--GDKYEVRVKGPNVTPGYHKDPELTAAAFDE 450
|
410 420 430
....*....|....*....|....*....|
gi 2740590833 402 DGFYRTGDLVRI----RPDGNLLVEGRIKE 427
Cdd:PRK12582 451 EGFYRLGDAARFvdpdDPEKGLIFDGRVAE 480
|
|
| PRK07824 |
PRK07824 |
o-succinylbenzoate--CoA ligase; |
381-524 |
7.78e-13 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 71.23 E-value: 7.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 381 GPYTITGYYRAEQHNtvAFTTDGFYRTGDLVRIRpDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVP 460
Cdd:PRK07824 214 GPTLAKGYRNPVDPD--PFAEPGWFRTDDLGALD-DGVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVFGLP 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2740590833 461 DELLGERICAC-LPKSINQPDPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQM 524
Cdd:PRK07824 291 DDRLGQRVVAAvVGDGGPAPTLEALRAHV-ARTLDRTAAPRELHVVDELPRRGIGKVDRRALVRR 354
|
|
| PRK06060 |
PRK06060 |
p-hydroxybenzoic acid--AMP ligase FadD22; |
35-521 |
1.98e-12 |
|
p-hydroxybenzoic acid--AMP ligase FadD22;
Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 71.22 E-value: 1.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 35 WGNKTALiYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTqrahdvhal 114
Cdd:PRK06060 19 WYDRPAF-YAADVVTHGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPE--------- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 cqiarpvayiipdcIHGFDYREMAREVAAS--------CPELEHIIVDGEAEEFIPFASIEDEPLNIIGpgyGDIAVL-L 185
Cdd:PRK06060 89 --------------LHRDDHALAARNTEPAlvvtsdalRDRFQPSRVAEAAELMSEAARVAPGGYEPMG---GDALAYaT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 186 LSGGTTGTPK-LIPRTHDAYTYNFVLSARLCAINTESVYLAVLPVAHNFILGSPGILGTLSQGGCVLLSDTASCDEAMPL 264
Cdd:PRK06060 152 YTSGTTGPPKaAIHRHADPLTFVDAMCRKALRLTPEDTGLCSARMYFAYGLGNSVWFPLATGGSAVINSAPVTPEAAAIL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 265 IEEHKVTHLALVPA-LARLWEQArdwEQSDLSSLRCLQVGGGRLTPELAEQVMARLG--PLQQVFGTAE-GLLCYTRLDD 340
Cdd:PRK06060 232 SARFGPSVLYGVPNfFARVIDSC---SPDSFRSLRCVVSAGEALELGLAERLMEFFGgiPILDGIGSTEvGQTFVSNRVD 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 PYEViiNTQGRPLSEEdEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHntvAFTTDGFYRTGDLVRIRPDGNLL 420
Cdd:PRK06060 309 EWRL--GTLGRVLPPY-EIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDS---PVANEGWLDTRDRVCIDSDGWVT 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 421 VEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAfLHQKGVQR---H 496
Cdd:PRK06060 383 YRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLvATSGATIDGSVMRD-LHRGLLNRlsaF 461
|
490 500
....*....|....*....|....*
gi 2740590833 497 KIPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK06060 462 KVPHRFAVVDRLPRTPNGKLVRGAL 486
|
|
| hsFATP2a_ACSVL_like |
cd05938 |
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ... |
43-460 |
1.77e-11 |
|
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 67.70 E-value: 1.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 43 YHEQRLTYHELHQSAERLANGLY-HRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPV 121
Cdd:cd05938 1 FEGETYTYRDVDRRSNQAARALLaHAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 122 AYIIpdcihGFDYREMAREVaasCPEL----------------EHII-----VDGEAEEFIPfASIEDEPLNIigpgygD 180
Cdd:cd05938 81 VLVV-----APELQEAVEEV---LPALradgvsvwylshtsntEGVIslldkVDAASDEPVP-ASLRAHVTIK------S 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 181 IAVLLLSGGTTGTPKLIPRTHDAYTY-NFVLsaRLCAINTESVYLAVLPVAHN--FILGspgILGTLSQGG-CVLLSD-T 255
Cdd:cd05938 146 PALYIYTSGTTGLPKAARISHLRVLQcSGFL--SLCGVTADDVIYITLPLYHSsgFLLG---IGGCIELGAtCVLKPKfS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 256 ASC--DEAmpliEEHKVTHLALVPALAR-LWEQARDWEQSDlSSLRcLQVGGGrLTPELAEQVMARLGPLQ--QVFGTAE 330
Cdd:cd05938 221 ASQfwDDC----RKHNVTVIQYIGELLRyLCNQPQSPNDRD-HKVR-LAIGNG-LRADVWREFLRRFGPIRirEFYGSTE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 331 G---LLCYT-------------RLDDPYEVIintqgRPLSEEDE-INLADTNLQPVAPSEVGELITRgpytIT------G 387
Cdd:cd05938 294 GnigFFNYTgkigavgrvsylyKLLFPFELI-----KFDVEKEEpVRDAQGFCIPVAKGEPGLLVAK----ITqqspflG 364
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2740590833 388 YYRAEQHNT------VAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVP 460
Cdd:cd05938 365 YAGDKEQTEkkllrdVFKKGDVYFNTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADVLGLLDFLQEVNVYGVT 443
|
|
| PTZ00237 |
PTZ00237 |
acetyl-CoA synthetase; Provisional |
159-522 |
2.18e-11 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 67.84 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 159 EFIPFASieDEPLNIIgpgygdiavllLSGGTTGTPKLIPRTHDAYTYNFVLSARLCAI-NTESVYLAVLPVA----HNF 233
Cdd:PTZ00237 247 EYVPVES--SHPLYIL-----------YTSGTTGNSKAVVRSNGPHLVGLKYYWRSIIEkDIPTVVFSHSSIGwvsfHGF 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 234 ILGSPGILGT--LSQGGcvLLSDTASCDEAMPLIEEHKVTH-LALVPALARLWEQARDWEQ----SDLSSLRCLQVGGGR 306
Cdd:PTZ00237 314 LYGSLSLGNTfvMFEGG--IIKNKHIEDDLWNTIEKHKVTHtLTLPKTIRYLIKTDPEATIirskYDLSNLKEIWCGGEV 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 307 LTPELAEQVMARLG-PLQQVFGTAEG----LLCYTRLDDPYeviiNTQGRP--------LSEeDEINLADtnlqpvapSE 373
Cdd:PTZ00237 392 IEESIPEYIENKLKiKSSRGYGQTEIgityLYCYGHINIPY----NATGVPsifikpsiLSE-DGKELNV--------NE 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 374 VGELITRGP----YTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHP 449
Cdd:PTZ00237 459 IGEVAFKLPmppsFATTFYKNDEKFKQLFSKFPGYYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHP 538
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 450 DIDDTVVIAVPDELLGERICACL----PKSINQPDPAQMQA---FLHQKGVQRHKIPDQWLFVAYWPLTAVGKInKRQLV 522
Cdd:PTZ00237 539 LVLECCSIGIYDPDCYNVPIGLLvlkqDQSNQSIDLNKLKNeinNIITQDIESLAVLRKIIIVNQLPKTKTGKI-PRQII 617
|
|
| prpE |
PRK10524 |
propionyl-CoA synthetase; Provisional |
36-526 |
2.42e-11 |
|
propionyl-CoA synthetase; Provisional
Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 67.67 E-value: 2.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIY------HEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGA-HPVLLMPTQrA 108
Cdd:PRK10524 67 PEQLALIAvstetdEERTYTFRQLHDEVNRMAAMLRSLGVQRGDRVLIYMPMIAEAAFAMLACARIGAiHSVVFGGFA-S 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 109 HDVHALCQIARPVAYIIPDC-IHG---FDYREM---AREVAASCPelEHI-IVD-GEAEEF------IPFASIEDEPLNI 173
Cdd:PRK10524 146 HSLAARIDDAKPVLIVSADAgSRGgkvVPYKPLldeAIALAQHKP--RHVlLVDrGLAPMArvagrdVDYATLRAQHLGA 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 174 IGP----GYGDIAVLLLSGGTTGTPKLIPRthDAYTYNFVLSARLCAI---NTESVYLAV----LPVAHNFILGSPGILG 242
Cdd:PRK10524 224 RVPvewlESNEPSYILYTSGTTGKPKGVQR--DTGGYAVALATSMDTIfggKAGETFFCAsdigWVVGHSYIVYAPLLAG 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 243 TLSqggcVLLsdtascdEAMP----------LIEEHKVTHLALVPALAR-LWEQARDW-EQSDLSSLRCLQVGGGRLTPE 310
Cdd:PRK10524 302 MAT----IMY-------EGLPtrpdagiwwrIVEKYKVNRMFSAPTAIRvLKKQDPALlRKHDLSSLRALFLAGEPLDEP 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 311 LAEQVMARLG-P-LQQVFGTAEG--LLCYTRLDDPYEVIINTQGRPLSEEDEINLADTNLQPVAPSEVGELITRGPY--- 383
Cdd:PRK10524 371 TASWISEALGvPvIDNYWQTETGwpILAIARGVEDRPTRLGSPGVPMYGYNVKLLNEVTGEPCGPNEKGVLVIEGPLppg 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 384 ---TITG--------YYRAEQHNTvafttdgfYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDID 452
Cdd:PRK10524 451 cmqTVWGdddrfvktYWSLFGRQV--------YSTFDWGIRDADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVA 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 453 DTVVIAVPDELLGERICA-CLPK---SINQPDPAQ------MQAFLHQKG-VQRhkiPDQWLFVAYWPLTAVGKINKRQL 521
Cdd:PRK10524 523 EVAVVGVKDALKGQVAVAfVVPKdsdSLADREARLalekeiMALVDSQLGaVAR---PARVWFVSALPKTRSGKLLRRAI 599
|
....*
gi 2740590833 522 VQMAQ 526
Cdd:PRK10524 600 QAIAE 604
|
|
| PRK13566 |
PRK13566 |
anthranilate synthase component I; |
761-968 |
1.30e-10 |
|
anthranilate synthase component I;
Pssm-ID: 237429 [Multi-domain] Cd Length: 720 Bit Score: 65.32 E-value: 1.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 761 RQANTPARSFF--LRDGDFsAYGFSPETVVEAEGSGwINTQPLAGTRALTHDKKQD-QQLRAdLLSDPKEISEhavsvkl 837
Cdd:PRK13566 287 KEINPSPYGFFinLGDGEY-LVGASPEMFVRVEGRR-VETCPISGTIKRGADAIGDaEQIRK-LLNSKKDESE------- 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 838 aleeLapicqpeTLCV-------SEfmaICERGSVQHLASR--------------VKGLLHTDKNRWDAFIALFPAVTAS 896
Cdd:PRK13566 357 ----L-------TMCTdvdrndkSR---VCEPGSVKVIGRRqiemysrlihtvdhVEGRLRPGFDALDAFLTHAWAVTVT 422
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740590833 897 GIPKKPALHTISRYEGEPRRLYSGCVMLLDSTGKLDAALVLRSLYQHKERCWLQAGAGLVRNSRPEREWQET 968
Cdd:PRK13566 423 GAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEVRVGATLLFDSDPEAEEAET 494
|
|
| PRK04813 |
PRK04813 |
D-alanine--poly(phosphoribitol) ligase subunit DltA; |
355-523 |
2.97e-10 |
|
D-alanine--poly(phosphoribitol) ligase subunit DltA;
Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 63.76 E-value: 2.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 355 EEDEINLADTNLQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTT-DG--FYRTGDLVRIrPDGNLLVEGRIKEQINR 431
Cdd:PRK04813 325 PDSPLLIIDEEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEAFFTfDGqpAYHTGDAGYL-EDGLLFYQGRIDFQIKL 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 432 SGEKISTLEVETLLLQHPDIDDTVVIAV-PDELLGERICACLPKSINQPDPAQMQAFLHQ---KGVQRHKIPDQWLFVAY 507
Cdd:PRK04813 404 NGYRIELEEIEQNLRQSSYVESAVVVPYnKDHKVQYLIAYVVPKEEDFEREFELTKAIKKelkERLMEYMIPRKFIYRDS 483
|
170
....*....|....*.
gi 2740590833 508 WPLTAVGKINKRQLVQ 523
Cdd:PRK04813 484 LPLTPNGKIDRKALIE 499
|
|
| PRK09192 |
PRK09192 |
fatty acyl-AMP ligase; |
48-468 |
1.37e-09 |
|
fatty acyl-AMP ligase;
Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 61.94 E-value: 1.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPV-LLMPT---QRAHDVHAL---CQIARP 120
Cdd:PRK09192 50 LPYQTLRARAEAGARRLLALGLKPGDRVALIAETDGDFVEAFFACQYAGLVPVpLPLPMgfgGRESYIAQLrgmLASAQP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 121 VAYIIPDcihgfDYREMAREVAASCPELehiiVDGEAEEFIPFASiEDEPLNIIGPGygDIAVLLLSGGTTGTPKLIPRT 200
Cdd:PRK09192 130 AAIITPD-----ELLPWVNEATHGNPLL----HVLSHAWFKALPE-ADVALPRPTPD--DIAYLQYSSGSTRFPRGVIIT 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 201 HDAytynfvLSARLCAINTESVYL-----AV--LPVAHNfiLGSPGILgtLSQGGCVLLSD-TASCDEAM-P-----LIE 266
Cdd:PRK09192 198 HRA------LMANLRAISHDGLKVrpgdrCVswLPFYHD--MGLVGFL--LTPVATQLSVDyLPTRDFARrPlqwldLIS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 267 EHKVThLALVPAL-----ARLWEQArDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLGPL---QQVF----GTAEGLLC 334
Cdd:PRK09192 268 RNRGT-ISYSPPFgyelcARRVNSK-DLAELDLSCWRVAGIGADMIRPDVLHQFAEAFAPAgfdDKAFmpsyGLAEATLA 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 335 YT-----------RLD------DPYEVIINTQGRPLSE---------EDEINLADTNLQPVAPSEVGELITRGPYTITGY 388
Cdd:PRK09192 346 VSfsplgsgivveEVDrdrleyQGKAVAPGAETRRVRTfvncgkalpGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGY 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 389 YRaEQHNTVAFTTDGFYRTGDLvRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDID--DTVVIAVPDElLGE 466
Cdd:PRK09192 426 FR-DEESQDVLAADGWLDTGDL-GYLLDGYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELRsgDAAAFSIAQE-NGE 502
|
..
gi 2740590833 467 RI 468
Cdd:PRK09192 503 KI 504
|
|
| PRK08180 |
PRK08180 |
feruloyl-CoA synthase; Reviewed |
46-427 |
3.44e-09 |
|
feruloyl-CoA synthase; Reviewed
Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 60.66 E-value: 3.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFvvtcfALFRLGAH-------PVL----LMPTQRAHdVHAL 114
Cdd:PRK08180 68 RRLTYAEALERVRAIAQALLDRGLSAERPLMILSGNSIEH-----ALLALAAMyagvpyaPVSpaysLVSQDFGK-LRHV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 115 CQIARPvAYIIPDcihgfDYREMAREVAASCPE-LEHIIVDGEAEE--FIPFASIEDEP--------LNIIGPGygDIAV 183
Cdd:PRK08180 142 LELLTP-GLVFAD-----DGAAFARALAAVVPAdVEVVAVRGAVPGraATPFAALLATPptaavdaaHAAVGPD--TIAK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 184 LLLSGGTTGTPKLIPRTHdaytynfvlsARLCAI------------NTESVYLAVLPVAHNFilGSPGILG-TLSQGGCV 250
Cdd:PRK08180 214 FLFTSGSTGLPKAVINTH----------RMLCANqqmlaqtfpflaEEPPVLVDWLPWNHTF--GGNHNLGiVLYNGGTL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 251 LLsdtascDEAMP---LIEEhKVTHL----------------ALVPALarlwEQARDWEQSDLSSLRCLQVGGGRLTP-- 309
Cdd:PRK08180 282 YI------DDGKPtpgGFDE-TLRNLreisptvyfnvpkgweMLVPAL----ERDAALRRRFFSRLKLLFYAGAALSQdv 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 310 -----ELAEQVMARLGPLQQVFGTAE----GLLCYTRLDDPYEViintqGRPLSEeDEINL--ADTNLqpvapsevgELI 378
Cdd:PRK08180 351 wdrldRVAEATCGERIRMMTGLGMTEtapsATFTTGPLSRAGNI-----GLPAPG-CEVKLvpVGGKL---------EVR 415
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2740590833 379 TRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRI----RPDGNLLVEGRIKE 427
Cdd:PRK08180 416 VKGPNVTPGYWRAPELTAEAFDEEGYYRSGDAVRFvdpaDPERGLMFDGRIAE 468
|
|
| PLN02736 |
PLN02736 |
long-chain acyl-CoA synthetase |
48-426 |
4.59e-09 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 178337 [Multi-domain] Cd Length: 651 Bit Score: 60.11 E-value: 4.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVA-YIIP 126
Cdd:PLN02736 79 MTYGEAGTARTAIGSGLVQHGIPKGACVGLYFINRPEWLIVDHACSAYSYVSVPLYDTLGPDAVKFIVNHAEVAAiFCVP 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 127 DCIhgfdyrEMAREVAASCPELEHIIVDGEAE------------EFIPFASIEDE----PLNIIGPGYGDIAVLLLSGGT 190
Cdd:PLN02736 159 QTL------NTLLSCLSEIPSVRLIVVVGGADeplpslpsgtgvEIVTYSKLLAQgrssPQPFRPPKPEDVATICYTSGT 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 191 TGTPKLIPRTHdaytYNFVLSARLCAINTES----VYLAVLPVAHnfILGSPGILGTLSQGGCV---------LLSDtas 257
Cdd:PLN02736 233 TGTPKGVVLTH----GNLIANVAGSSLSTKFypsdVHISYLPLAH--IYERVNQIVMLHYGVAVgfyqgdnlkLMDD--- 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 258 cdeamplIEEHKVTHLALVPalaRLWEQARD-------------------------------------WEQSDLSSLRcl 300
Cdd:PLN02736 304 -------LAALRPTIFCSVP---RLYNRIYDgitnavkesgglkerlfnaaynakkqalengknpspmWDRLVFNKIK-- 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 301 QVGGGRL-------TPeLAEQVMARL-----GPLQQVFGTAEG--LLCYTRLDDpyeviiNTQGRPLSEED--EINLAD- 363
Cdd:PLN02736 372 AKLGGRVrfmssgaSP-LSPDVMEFLricfgGRVLEGYGMTETscVISGMDEGD------NLSGHVGSPNPacEVKLVDv 444
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 364 -----TNLQpvAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIK 426
Cdd:PLN02736 445 pemnyTSED--QPYPRGEICVRGPIIFKGYYKDEVQTREVIDEDGWLHTGDIGLWLPGGRLKIIDRKK 510
|
|
| PTZ00216 |
PTZ00216 |
acyl-CoA synthetase; Provisional |
297-449 |
6.84e-09 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240316 [Multi-domain] Cd Length: 700 Bit Score: 59.60 E-value: 6.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 297 LRCLQVGGGRLTPELAEQVMARLGPLQQVFGTAEGLLCYT--RLDDPYEVIIntqGRPLSEEdEINLADTN--LQPVAPS 372
Cdd:PTZ00216 430 VRAMLSGGGPLSAATQEFVNVVFGMVIQGWGLTETVCCGGiqRTGDLEPNAV---GQLLKGV-EMKLLDTEeyKHTDTPE 505
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 373 EVGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQI-NRSGEKISTLEVETLLLQHP 449
Cdd:PTZ00216 506 PRGEILLRGPFLFKGYYKQEELTREVLDEDGWFHTGDVGSIAANGTLRIIGRVKALAkNCLGEYIALEALEALYGQNE 583
|
|
| AMP-binding_C |
pfam13193 |
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ... |
440-515 |
8.32e-09 |
|
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.
Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 52.93 E-value: 8.32e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2740590833 440 EVETLLLQHPDIDDTVVIAVPDELLGERICACL-PKSINQPDPAQMQAFLhQKGVQRHKIPDQWLFVAYWPLTAVGK 515
Cdd:pfam13193 1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVvLKPGVELLEEELVAHV-REELGPYAVPKEVVFVDELPKTRSGK 76
|
|
| PRK03584 |
PRK03584 |
acetoacetate--CoA ligase; |
36-457 |
8.72e-09 |
|
acetoacetate--CoA ligase;
Pssm-ID: 235134 [Multi-domain] Cd Length: 655 Bit Score: 59.42 E-value: 8.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYH-----EQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAhpvllmptqrahd 110
Cdd:PRK03584 98 DDRPAIIFRgedgpRRELSWAELRRQVAALAAALRALGVGPGDRVAAYLPNIPETVVAMLATASLGA------------- 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 111 VHALC--------------QIArPVAYIIPDcihG-------FDYREMAREVAASCPELEHIIV---------------- 153
Cdd:PRK03584 165 IWSSCspdfgvqgvldrfgQIE-PKVLIAVD---GyryggkaFDRRAKVAELRAALPSLEHVVVvpylgpaaaaaalpga 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 154 --------DGEAEEF----IPFasieDEPLNIigpgygdiavlLLSGGTTGTPKLIPRTHDAYTYNFVLSARL-CAINTE 220
Cdd:PRK03584 241 llwedflaPAEAAELefepVPF----DHPLWI-----------LYSSGTTGLPKCIVHGHGGILLEHLKELGLhCDLGPG 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 221 SVYlavlpvahnFILGSPG------ILGTLSQGGCVLLSD--------TASCDeampLIEEHKVTHLA------------ 274
Cdd:PRK03584 306 DRF---------FWYTTCGwmmwnwLVSGLLVGATLVLYDgspfypdpNVLWD----LAAEEGVTVFGtsakyldaceka 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 275 -LVPAlarlweqardwEQSDLSSLRCLQVGGGRLTPE----LAEQVMARL------------------GPLQQVF-G--T 328
Cdd:PRK03584 373 gLVPG-----------ETHDLSALRTIGSTGSPLPPEgfdwVYEHVKADVwlasisggtdicscfvggNPLLPVYrGeiQ 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 329 AEGLLCytRLDdpyevIINTQGRPLSEedeinladtnlqpvapsEVGEL-ITRG-PYTITGY--------YRAeqhntvA 398
Cdd:PRK03584 442 CRGLGM--AVE-----AWDEDGRPVVG-----------------EVGELvCTKPfPSMPLGFwndpdgsrYRD------A 491
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2740590833 399 F--TTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLE----VETLllqhPDIDDTVVI 457
Cdd:PRK03584 492 YfdTFPGVWRHGDWIEITEHGGVVIYGRSDATLNRGGVRIGTAEiyrqVEAL----PEVLDSLVI 552
|
|
| hsFATP4_like |
cd05939 |
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ... |
46-459 |
1.47e-08 |
|
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 58.21 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAhdvhalcqiarpvayii 125
Cdd:cd05939 2 RHWTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRL----------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 pdcihgfdyremarevaascPELEHIIVDGEAEEFIP------FASIEDEPLNIIGPGYGDIAVLLLSGGTTGTPKLIPR 199
Cdd:cd05939 65 --------------------ESLLHCITVSKAKALIFnlldplLTQSSTEPPSQDDVNFRDKLFYIYTSGTTGLPKAAVI 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 200 THDAYTYNFVLSARLCAINTESVYLAVLPVAHNfilgSPGILGTlsqGGCVLLSDTAS-------------CDeamplie 266
Cdd:cd05939 125 VHSRYYRIAAGAYYAFGMRPEDVVYDCLPLYHS----AGGIMGV---GQALLHGSTVVirkkfsasnfwddCV------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 267 EHKVTHLALVPALAR--LWEQARDWEQSdlSSLRcLQVGGGrLTPELAEQVMARLGPLQ--QVFGTAEGLLCYTRLDDP- 341
Cdd:cd05939 191 KYNCTIVQYIGEICRylLAQPPSEEEQK--HNVR-LAVGNG-LRPQIWEQFVRRFGIPQigEFYGATEGNSSLVNIDNHv 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 342 ----YEVIINTQGRPLS----EEDEINL---ADTNLQPVAPSE----VGELITRGPYT-ITGYY-RAEQHNTVA---FTT 401
Cdd:cd05939 267 gacgFNSRILPSVYPIRlikvDEDTGELirdSDGLCIPCQPGEpgllVGKIIQNDPLRrFDGYVnEGATNKKIArdvFKK 346
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 2740590833 402 -DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAV 459
Cdd:cd05939 347 gDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGV 405
|
|
| ACSBG_like |
cd05933 |
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ... |
46-445 |
2.74e-08 |
|
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341256 [Multi-domain] Cd Length: 596 Bit Score: 57.75 E-value: 2.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 46 QRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHalcqiarpvaYII 125
Cdd:cd05933 7 HTLTYKEYYEACRQAAKAFLKLGLERFHGVGILGFNSPEWFIAAVGAIFAGGIAVGIYTTNSPEACQ----------YVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 126 PDCIHGF----DYREMAR--EVAASCPELEHIIVDGEA-----------EEFIPFA-SIEDEPL-NIIG---PGygDIAV 183
Cdd:cd05933 77 ETSEANIlvveNQKQLQKilQIQDKLPHLKAIIQYKEPlkekepnlyswDEFMELGrSIPDEQLdAIISsqkPN--QCCT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 184 LLLSGGTTGTPKLIPRTHDAYTYNFVLSAR----LCAINTESVYLAVLPVAHnfilgsPG-----ILGTLSQGGCVLLSD 254
Cdd:cd05933 155 LIYTSGTTGMPKGVMLSHDNITWTAKAASQhmdlRPATVGQESVVSYLPLSH------IAaqildIWLPIKVGGQVYFAQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 255 TASCDEAMP-LIEEHKVTHLALVPalaRLWEQ----------------------ARD--------WEQSDLSSL------ 297
Cdd:cd05933 229 PDALKGTLVkTLREVRPTAFMGVP---RVWEKiqekmkavgaksgtlkrkiaswAKGvgletnlkLMGGESPSPlfyrla 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 298 ---------------RCLQV--GGGRLTPELAEQVMARLGPLQQVFGTAEGLLCYTrLDDPYEVIINTQGRPLSE-EDEI 359
Cdd:cd05933 306 kklvfkkvrkalgldRCQKFftGAAPISRETLEFFLSLNIPIMELYGMSETSGPHT-ISNPQAYRLLSCGKALPGcKTKI 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 360 NLADTNLQpvapsevGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQI-NRSGEKIST 438
Cdd:cd05933 385 HNPDADGI-------GEICFWGRHVFMGYLNMEDKTEEAIDEDGWLHSGDLGKLDEDGFLYITGRIKELIiTAGGENVPP 457
|
....*..
gi 2740590833 439 LEVETLL 445
Cdd:cd05933 458 VPIEDAV 464
|
|
| PLN02654 |
PLN02654 |
acetate-CoA ligase |
386-538 |
3.11e-08 |
|
acetate-CoA ligase
Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 57.60 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 386 TGYYRAEQHNTVAFTT-DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELL 464
Cdd:PLN02654 495 TLYGDHERYETTYFKPfAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQCAEAAVVGIEHEVK 574
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 465 GERICAC------------LPKSINQPDPAQMQAFlhqkgvqrhKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENTET 532
Cdd:PLN02654 575 GQGIYAFvtlvegvpyseeLRKSLILTVRNQIGAF---------AAPDKIHWAPGLPKTRSGKIMRRILRKIASRQLDEL 645
|
....*.
gi 2740590833 533 AENNSL 538
Cdd:PLN02654 646 GDTSTL 651
|
|
| PLN03051 |
PLN03051 |
acyl-activating enzyme; Provisional |
159-530 |
8.53e-07 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215552 [Multi-domain] Cd Length: 499 Bit Score: 52.90 E-value: 8.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 159 EFIPFASIEDEPLNIigpgygdiavlLLSGGTTGTPKLIPRTHdaytynfvLSARLCA--------INTESVYlaVLPVA 230
Cdd:PLN03051 110 EYSPVYAPVESVTNI-----------LFSSGTTGEPKAIPWTH--------LSPLRCAsdgwahmdIQPGDVV--CWPTN 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 231 HNFILGSPGILGTLSQGGCVLLSDTAscdeamPL-------IEEHKVTHLALVPALARLWEQ--ARDWEQSDLSSLRCLQ 301
Cdd:PLN03051 169 LGWMMGPWLLYSAFLNGATLALYGGA------PLgrgfgkfVQDAGVTVLGLVPSIVKAWRHtgAFAMEGLDWSKLRVFA 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 302 VGGGRLTPELAEQVMARLG----------------------PLQ-QVFGTAEGLLCYTRLddpyeVIINTQGRPLSEEde 358
Cdd:PLN03051 243 STGEASAVDDVLWLSSVRGyykpvieycggtelasgyisstLLQpQAPGAFSTASLGTRF-----VLLNDNGVPYPDD-- 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 359 inladtnlQPVapseVGELITRGPYT-ITGYYRAEQHNTVAFTTDGFY--------RTGDLVRIRPDGNLLVEGRIKEQI 429
Cdd:PLN03051 316 --------QPC----VGEVALAPPMLgASDRLLNADHDKVYYKGMPMYgskgmplrRHGDIMKRTPGGYFCVQGRADDTM 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 430 NRSGEKISTLEVETLLLQHPD-IDDTVVIAV------PDELLGERICACLPKSINQPDPAQMQAfLHQKGVQRHKIPdqw 502
Cdd:PLN03051 384 NLGGIKTSSVEIERACDRAVAgIAETAAVGVappdggPELLVIFLVLGEEKKGFDQARPEALQK-KFQEAIQTNLNP--- 459
|
410 420 430
....*....|....*....|....*....|....*
gi 2740590833 503 LF-------VAYWPLTAVGKINKRQLVQMAQAENT 530
Cdd:PLN03051 460 LFkvsrvkiVPELPRNASNKLLRRVLRDQLKKELS 494
|
|
| PTZ00342 |
PTZ00342 |
acyl-CoA synthetase; Provisional |
303-456 |
9.68e-07 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240370 [Multi-domain] Cd Length: 746 Bit Score: 52.80 E-value: 9.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 303 GGGRLTPELAEQVMARLG-PLQQVFGTAE---GLLCYTRLDDPYEVIintqGRPLSEED-------EINLADTNLqpvaP 371
Cdd:PTZ00342 469 GGGKLSPKIAEELSVLLNvNYYQGYGLTEttgPIFVQHADDNNTESI----GGPISPNTkykvrtwETYKATDTL----P 540
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 372 SevGELITRGPYTITGYYRAEQHNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRS-GEKISTLEVETLLLQHPD 450
Cdd:PTZ00342 541 K--GELLIKSDSIFSGYFLEKEQTKNAFTEDGYFKTGDIVQINKNGSLTFLDRSKGLVKLSqGEYIETDMLNNLYSQISF 618
|
....*.
gi 2740590833 451 IDDTVV 456
Cdd:PTZ00342 619 INFCVV 624
|
|
| PRK05851 |
PRK05851 |
long-chain-fatty acid--ACP ligase MbtM; |
175-459 |
1.79e-06 |
|
long-chain-fatty acid--ACP ligase MbtM;
Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 51.69 E-value: 1.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 175 GPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTYNFV-LSARLCAINTESVYLAVLPVAHNfiLGSPGILGTLSQGGCVLLS 253
Cdd:PRK05851 148 PPDSGGPAVLQGTAGSTGTPRTAILSPGAVLSNLRgLNARVGLDAATDVGCSWLPLYHD--MGLAFLLTAALAGAPLWLA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 254 DTASCdEAMPL-----IEEHKVTHLAlVPALAR--LWEQARDWEQSDLSSLRcLQVGGGRLTP----ELAEQVMARLG-- 320
Cdd:PRK05851 226 PTTAF-SASPFrwlswLSDSRATLTA-APNFAYnlIGKYARRVSDVDLGALR-VALNGGEPVDcdgfERFATAMAPFGfd 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 321 --PLQQVFGTAE------------GLLcYTRLDDPYEVIINTQ---GRPLSEEdEINLADTN-LQPVAPSEVGELITRGP 382
Cdd:PRK05851 303 agAAAPSYGLAEstcavtvpvpgiGLR-VDEVTTDDGSGARRHavlGNPIPGM-EVRISPGDgAAGVAGREIGEIEIRGA 380
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2740590833 383 YTITGYYRAEqhntvAFTTDGFYRTGDLVRIRpDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAV 459
Cdd:PRK05851 381 SMMSGYLGQA-----PIDPDDWFPTGDLGYLV-DGGLVVCGRAKELITVAGRNIFPTEIERVAAQVRGVREGAVVAV 451
|
|
| PLN02430 |
PLN02430 |
long-chain-fatty-acid-CoA ligase |
167-456 |
1.92e-06 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 51.74 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 167 EDEPLNIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDAYTyNFVLSARLC------AINTESVYLAVLPVAH-------NF 233
Cdd:PLN02430 208 KENPSETNPPKPLDICTIMYTSGTSGDPKGVVLTHEAVA-TFVRGVDLFmeqfedKMTHDDVYLSFLPLAHildrmieEY 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 234 ILGSPGILGTLSQGGCVLLSDtascdeamplIEEHKVTHLALVPalaRLWEQARDWEQSDLSSLR--------------- 298
Cdd:PLN02430 287 FFRKGASVGYYHGDLNALRDD----------LMELKPTLLAGVP---RVFERIHEGIQKALQELNprrrlifnalykykl 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 299 ------CLQVGGGRLTPELA-EQVMARLG-----------PLQ----------------QVFGTAEGL----LCYtrldd 340
Cdd:PLN02430 354 awmnrgYSHKKASPMADFLAfRKVKAKLGgrlrllisggaPLSteieeflrvtscafvvQGYGLTETLgpttLGF----- 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 341 PYEV-IINTQGRPlSEEDEINLADT---NLQPVAPSEVGELITRGPYTITGYYRAEQHnTVAFTTDGFYRTGDLVRIRPD 416
Cdd:PLN02430 429 PDEMcMLGTVGAP-AVYNELRLEEVpemGYDPLGEPPRGEICVRGKCLFSGYYKNPEL-TEEVMKDGWFHTGDIGEILPN 506
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2740590833 417 GNLLVEGRIKEQINRS-GEKISTLEVETLLLQHPDIDDTVV 456
Cdd:PLN02430 507 GVLKIIDRKKNLIKLSqGEYVALEYLENVYGQNPIVEDIWV 547
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
180-530 |
2.00e-06 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 51.63 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 180 DIAVLLLSGGTTGTPKLIPRTHDAYTYNfVLSARLCAINT-ESVYLAVLPVAHNFILgSPGILGTLSQGGCVLLSDTasc 258
Cdd:PRK08043 366 DAALILFTSGSEGHPKGVVHSHKSLLAN-VEQIKTIADFTpNDRFMSALPLFHSFGL-TVGLFTPLLTGAEVFLYPS--- 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 259 deamPLieehkvtHLALVPALAR-------------LWEQARDWEQSDLSSLRCLQVGGGRLTPELAEQVMARLG-PLQQ 324
Cdd:PRK08043 441 ----PL-------HYRIVPELVYdrnctvlfgtstfLGNYARFANPYDFARLRYVVAGAEKLQESTKQLWQDKFGlRILE 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 325 VFGTAEgllC--YTRLDDPYEVIINTQGRPLSEedeinlADTNLQPVAPSEVG-ELITRGPYTITGYYRAEQ-------- 393
Cdd:PRK08043 510 GYGVTE---CapVVSINVPMAAKPGTVGRILPG------MDARLLSVPGIEQGgRLQLKGPNIMNGYLRVEKpgvlevpt 580
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 394 -HNTVAFTTDGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVIAVPDELLGERIcaCL 472
Cdd:PRK08043 581 aENARGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKQHATAIKSDASKGEAL--VL 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2740590833 473 PKSINQPDPAQMQAFLHQKGVQRHKIPDQWLFVAYWPLTAVGKINKRQLVQMAQAENT 530
Cdd:PRK08043 659 FTTDSELTREKLQQYAREHGVPELAVPRDIRYLKQLPLLGSGKPDFVTLKSMVDEPEQ 716
|
|
| PLN02387 |
PLN02387 |
long-chain-fatty-acid-CoA ligase family protein |
162-460 |
1.12e-05 |
|
long-chain-fatty-acid-CoA ligase family protein
Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 49.34 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 162 PFASIE----DEPLNIIGPGYGDIAVLLLSGGTTGTPKLIPRTHDaytyNFVLSAR-----LCAINTESVYLAVLPVAHN 232
Cdd:PLN02387 229 SFSEVEklgkENPVDPDLPSPNDIAVIMYTSGSTGLPKGVMMTHG----NIVATVAgvmtvVPKLGKNDVYLAYLPLAHI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 233 FILGSPGIL----GTLSQGGCVLLSDTAS-------CDEAMplieeHKVTHLALVPAL---------------------- 279
Cdd:PLN02387 305 LELAAESVMaavgAAIGYGSPLTLTDTSNkikkgtkGDASA-----LKPTLMTAVPAIldrvrdgvrkkvdakgglakkl 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 280 ------ARL------WEQARDWE------------QSDLS-SLRCLQVGGGRLTPELAEQVMARLG-PLQQVFGTAEglL 333
Cdd:PLN02387 380 fdiaykRRLaaiegsWFGAWGLEkllwdalvfkkiRAVLGgRIRFMLSGGAPLSGDTQRFINICLGaPIGQGYGLTE--T 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 334 C----YTRLDDPYeviINTQGRPLS---------EEDEINLADtnlqpvAPSEVGELITRGPYTITGYYRAEQHNTVAFT 400
Cdd:PLN02387 458 CagatFSEWDDTS---VGRVGPPLPccyvklvswEEGGYLISD------KPMPRGEIVIGGPSVTLGYFKNQEKTDEVYK 528
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740590833 401 TDG-----FYrTGDLVRIRPDGNLLVEGRIKEQIN-RSGEKISTLEVETLLLQHPDIDDTVVIAVP 460
Cdd:PLN02387 529 VDErgmrwFY-TGDIGQFHPDGCLEIIDRKKDIVKlQHGEYVSLGKVEAALSVSPYVDNIMVHADP 593
|
|
| A_NRPS_alphaAR |
cd17647 |
Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as ... |
49-457 |
1.38e-05 |
|
Alpha-aminoadipate reductase; This family contains L-2-aminoadipate reductase, also known as alpha-aminoadipate reductase (EC 1.2.1.95) or alpha-AR or L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), which catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.
Pssm-ID: 341302 [Multi-domain] Cd Length: 520 Bit Score: 49.05 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 49 TYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHALCQIARPVAYIIpdc 128
Cdd:cd17647 22 TYRDINEASNIVAHYLIKTGIKRGDVVMIYSYRGVDLMVAVMGVLKAGATFSVIDPAYPPARQNIYLGVAKPRGLIV--- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 129 ihgfdyremarevaascpelehiivdgeaeefipfasIEDEPLnIIGPGygDIAVLLLSGGTTGTPKLIPRTHDAYTYNF 208
Cdd:cd17647 99 -------------------------------------IRAAGV-VVGPD--SNPTLSFTSGSEGIPKGVLGRHFSLAYYF 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 209 VLSARLCAINTESVYLAVLPVAHNFI---LGSPGILGTlsqggcVLLSDTAScDEAMP-----LIEEHKVTHLALVPALA 280
Cdd:cd17647 139 PWMAKRFNLSENDKFTMLSGIAHDPIqrdMFTPLFLGA------QLLVPTQD-DIGTPgrlaeWMAKYGATVTHLTPAMG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 281 RLWeqARDWEQSDLSSLRCLQVGGgRLTPE--LAEQVMARLGPLQQVFGTAEG--LLCY----TRLDDPY------EVII 346
Cdd:cd17647 212 QLL--TAQATTPFPKLHHAFFVGD-ILTKRdcLRLQTLAENVRIVNMYGTTETqrAVSYfevpSRSSDPTflknlkDVMP 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 347 NTQGRPLSEEDEINLADTNlQPVAPSEVGELITRGPYTITGYYRAEQHNTVAFTTDGF---------------------- 404
Cdd:cd17647 289 AGRGMLNVQLLVVNRNDRT-QICGIGEVGEIYVRAGGLAEGYRGLPELNKEKFVNNWFvepdhwnyldkdnnepwrqfwl 367
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 2740590833 405 ------YRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHPDIDDTVVI 457
Cdd:cd17647 368 gprdrlYRTGDLGRYLPNGDCECCGRADDQVKIRGFRIELGEIDTHISQHPLVRENITL 426
|
|
| Dip2 |
cd05905 |
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of ... |
48-456 |
4.71e-05 |
|
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of the adenylate forming enzyme family, including insect luciferase, acetyl CoA ligases and the adenylation domain of nonribosomal peptide synthetases (NRPS). However, its function may have diverged from other members of the superfamily. In mouse embryo, Dip2 homolog A plays an important role in the development of both vertebrate and invertebrate nervous systems. Dip2A appears to regulate cell growth and the arrangement of cells in organs. Biochemically, Dip2A functions as a receptor of FSTL1, an extracellular glycoprotein, and may play a role as a cardiovascular protective agent.
Pssm-ID: 341231 [Multi-domain] Cd Length: 571 Bit Score: 47.34 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 48 LTYHELHQSAERLANGLYHR-GIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQRAHDVHAL---CQIARPVAY 123
Cdd:cd05905 15 LTWGKLLSRAEKIAAVLQKKvGLKPGDRVALMYPDPLDFVAAFYGCLYAGVVPIPIEPPDISQQLGFLlgtCKVRVALTV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 124 IIpdcihgfDYREMAREVAASCPELEHI-------IVDGEAE----EFIPFASIEDEPLNIigpgyGDIAVLLLSGGTTG 192
Cdd:cd05905 95 EA-------CLKGLPKKLLKSKTAAEIAkkkgwpkILDFVKIpkskRSKLKKWGPHPPTRD-----GDTAYIEYSFSSDG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 193 TPKLIPRTHDAytynfVLSArlCAINTESV-YLAVLPVAHNFILGSP-----GILGTLSQGGCVLLsdtasCDEA----- 261
Cdd:cd05905 163 SLSGVAVSHSS-----LLAH--CRALKEACeLYESRPLVTVLDFKSGlglwhGCLLSVYSGHHTIL-----IPPElmktn 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 262 ----MPLIEEHKVT---------HLALVPALARLweQARDWEQSDLSSLR-CLQVGGGRLTPELAEQVMARLGPL----- 322
Cdd:cd05905 231 pllwLQTLSQYKVRdayvklrtlHWCLKDLSSTL--ASLKNRDVNLSSLRmCMVPCENRPRISSCDSFLKLFQTLglspr 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 323 --QQVFGT----------------AEGLL-------CYTRLDD----PYEVIINTQGRPLSEEDEINLADTNLqPVAPSE 373
Cdd:cd05905 309 avSTEFGTrvnpficwqgtsgpepSRVYLdmralrhGVVRLDErdkpNSLPLQDSGKVLPGAQVAIVNPETKG-LCKDGE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 374 VGELITRGPYTITGYYRAEQHNTVAF------------TTDGFYRTGDLVRIRP----------DGNLLVEGRIKEQINR 431
Cdd:cd05905 388 IGEIWVNSPANASGYFLLDGETNDTFkvfpstrlstgiTNNSYARTGLLGFLRPtkctdlnveeHDLLFVVGSIDETLEV 467
|
490 500
....*....|....*....|....*.
gi 2740590833 432 SGEKISTLEVE-TLLLQHPDIDDTVV 456
Cdd:cd05905 468 RGLRHHPSDIEaTVMRVHPYRGRCAV 493
|
|
| alpha_am_amid |
TIGR03443 |
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ... |
402-449 |
6.12e-05 |
|
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.
Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 47.37 E-value: 6.12e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2740590833 402 DGFYRTGDLVRIRPDGNLLVEGRIKEQINRSGEKISTLEVETLLLQHP 449
Cdd:TIGR03443 677 DRLYRTGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHP 724
|
|
| PRK07868 |
PRK07868 |
acyl-CoA synthetase; Validated |
36-127 |
3.45e-04 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236121 [Multi-domain] Cd Length: 994 Bit Score: 44.71 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740590833 36 GNKTALIYHEQRLTYHELHQSAERLANGLYHRGIRRGDHVMVQLPNRISFVVTCFALFRLGAHPVLLMPTQrahDVHALC 115
Cdd:PRK07868 461 PKGEFLLFDGRVHTYEAVNRRINNVVRGLIAVGVRQGDRVGVLMETRPSALVAIAALSRLGAVAVLMPPDT---DLAAAV 537
|
90
....*....|..
gi 2740590833 116 QIARpVAYIIPD 127
Cdd:PRK07868 538 RLGG-VTEIITD 548
|
|
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