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Conserved domains on  [gi|2687344094|ref|WP_334103978|]
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MULTISPECIES: alanine:cation symporter family protein [Aminobacterium]

Protein Classification

ACGS family protein( domain architecture ID 207)

ACGS (alanine or glycine:cation symporter) family protein similar to Bacillus subtilis GlnT, which functions in glutamine uptake as a sodium:glutamine symporter

Gene Ontology:  GO:0005283|GO:0006814|GO:0006865|GO:0015293|GO:0016020
PubMed:  8031825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Na_Ala_symp super family cl00548
Sodium:alanine symporter family;
1-98 1.50e-44

Sodium:alanine symporter family;


The actual alignment was detected with superfamily member COG1115:

Pssm-ID: 469815  Cd Length: 450  Bit Score: 149.47  E-value: 1.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687344094   1 MEVVKFANGILWGKLMTWLLLGTGVFYSIRLWIPQFHHFGHTFKVLFGSRR--SEEGGITSFQALCTGLAAQVGTGNIAG 78
Cdd:COG1115     5 NEILNAINDFLWGPPLIILLLGTGLYFTIRLGFVQFRKFGHAFRLLFGKKKdkGGEGGISSFQALATALAATVGTGNIAG 84

                          90       100
                  ....*....|....*....|
gi 2687344094  79 VATALVSGGPGAVFWMWVTA 98
Cdd:COG1115    85 VATAIALGGPGAVFWMWVTA 104
 
Name Accession Description Interval E-value
AlsT COG1115
Na+/alanine symporter [Amino acid transport and metabolism];
1-98 1.50e-44

Na+/alanine symporter [Amino acid transport and metabolism];


Pssm-ID: 440732  Cd Length: 450  Bit Score: 149.47  E-value: 1.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687344094   1 MEVVKFANGILWGKLMTWLLLGTGVFYSIRLWIPQFHHFGHTFKVLFGSRR--SEEGGITSFQALCTGLAAQVGTGNIAG 78
Cdd:COG1115     5 NEILNAINDFLWGPPLIILLLGTGLYFTIRLGFVQFRKFGHAFRLLFGKKKdkGGEGGISSFQALATALAATVGTGNIAG 84

                          90       100
                  ....*....|....*....|
gi 2687344094  79 VATALVSGGPGAVFWMWVTA 98
Cdd:COG1115    85 VATAIALGGPGAVFWMWVTA 104
agcS TIGR00835
amino acid carrier protein; The Alanine or Glycine: Cation Symporter (AGCS) Family (TC 2.A.25) ...
 12-98 7.92e-29

amino acid carrier protein; The Alanine or Glycine: Cation Symporter (AGCS) Family (TC 2.A.25) Members of the AGCS family transport alanine and/or glycine in symport with Na+ and or H+.


Pssm-ID: 273291  Cd Length: 425  Bit Score: 107.40  E-value: 7.92e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687344094  12 WGKLMTWLLLGTGVFYSIRLWIPQFHHFGHTFKVLFGSRRSE-EGGITSFQALCTGLAAQVGTGNIAGVATALVSGGPGA 90
Cdd:TIGR00835   1 WGYPMFILLLGTGLFFTIRLGFVQFRYLPAAFRLLFGKRKEQgKGGVSSFQALFTSLAARVGIGNIVGVATAIAIGGPGA 80


                  ....*...
gi 2687344094  91 VFWMWVTA 98
Cdd:TIGR00835  81 VFWMWVTA 88
Na_Ala_symp pfam01235
Sodium:alanine symporter family;
48-98 2.95e-26

Sodium:alanine symporter family;


Pssm-ID: 460125  Cd Length: 385  Bit Score: 99.83  E-value: 2.95e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2687344094  48 GSRRSEEGGITSFQALCTGLAAQVGTGNIAGVATALVSGGPGAVFWMWVTA 98
Cdd:pfam01235   1 EKKKDGKGGISSFQALCTSLAARVGTGNIAGVATAIALGGPGAVFWMWVIA 51
 
Name Accession Description Interval E-value
AlsT COG1115
Na+/alanine symporter [Amino acid transport and metabolism];
1-98 1.50e-44

Na+/alanine symporter [Amino acid transport and metabolism];


Pssm-ID: 440732  Cd Length: 450  Bit Score: 149.47  E-value: 1.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687344094   1 MEVVKFANGILWGKLMTWLLLGTGVFYSIRLWIPQFHHFGHTFKVLFGSRR--SEEGGITSFQALCTGLAAQVGTGNIAG 78
Cdd:COG1115     5 NEILNAINDFLWGPPLIILLLGTGLYFTIRLGFVQFRKFGHAFRLLFGKKKdkGGEGGISSFQALATALAATVGTGNIAG 84

                          90       100
                  ....*....|....*....|
gi 2687344094  79 VATALVSGGPGAVFWMWVTA 98
Cdd:COG1115    85 VATAIALGGPGAVFWMWVTA 104
agcS TIGR00835
amino acid carrier protein; The Alanine or Glycine: Cation Symporter (AGCS) Family (TC 2.A.25) ...
 12-98 7.92e-29

amino acid carrier protein; The Alanine or Glycine: Cation Symporter (AGCS) Family (TC 2.A.25) Members of the AGCS family transport alanine and/or glycine in symport with Na+ and or H+.


Pssm-ID: 273291  Cd Length: 425  Bit Score: 107.40  E-value: 7.92e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687344094  12 WGKLMTWLLLGTGVFYSIRLWIPQFHHFGHTFKVLFGSRRSE-EGGITSFQALCTGLAAQVGTGNIAGVATALVSGGPGA 90
Cdd:TIGR00835   1 WGYPMFILLLGTGLFFTIRLGFVQFRYLPAAFRLLFGKRKEQgKGGVSSFQALFTSLAARVGIGNIVGVATAIAIGGPGA 80


                  ....*...
gi 2687344094  91 VFWMWVTA 98
Cdd:TIGR00835  81 VFWMWVTA 88
Na_Ala_symp pfam01235
Sodium:alanine symporter family;
48-98 2.95e-26

Sodium:alanine symporter family;


Pssm-ID: 460125  Cd Length: 385  Bit Score: 99.83  E-value: 2.95e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2687344094  48 GSRRSEEGGITSFQALCTGLAAQVGTGNIAGVATALVSGGPGAVFWMWVTA 98
Cdd:pfam01235   1 EKKKDGKGGISSFQALCTSLAARVGTGNIAGVATAIALGGPGAVFWMWVIA 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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