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Conserved domains on  [gi|2593739819|ref|WP_316409838|]
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carbonic anhydrase, partial [Klebsiella variicola]

Protein Classification

carbonic anhydrase( domain architecture ID 1865)

carbonic anhydrase (CA) catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton

CATH:  3.40.1050.10
EC:  4.2.1.1
Gene Ontology:  GO:0004089|GO:0008270
PubMed:  11696553|9336012
SCOP:  4000510

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta_CA super family cl00391
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 1-102 3.17e-56

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


The actual alignment was detected with superfamily member cd00883:

Pssm-ID: 469755  Cd Length: 182  Bit Score: 173.14  E-value: 3.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   1 WALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERV 80
Cdd:cd00883     4 WAEEKKAKDPDFFPRLAKGQTPEYLWIGCSDSRVPENTILGLLPGEVFVHRNIANLVSPTDLNCLSVLQYAVDVLKVKHI 83

                          90       100
                  ....*....|....*....|..
gi 2593739819  81 VLCGHYGCGGVQAALSLPTLPL 102
Cdd:cd00883    84 IVCGHYGCGGVKAALTGKRLGL 105
 
Name Accession Description Interval E-value
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 1-102 3.17e-56

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 173.14  E-value: 3.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   1 WALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERV 80
Cdd:cd00883     4 WAEEKKAKDPDFFPRLAKGQTPEYLWIGCSDSRVPENTILGLLPGEVFVHRNIANLVSPTDLNCLSVLQYAVDVLKVKHI 83

                          90       100
                  ....*....|....*....|..
gi 2593739819  81 VLCGHYGCGGVQAALSLPTLPL 102
Cdd:cd00883    84 IVCGHYGCGGVKAALTGKRLGL 105
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-102 1.37e-50

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 159.56  E-value: 1.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   1 WALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERV 80
Cdd:COG0288    14 FVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYDPGVLASIEYAVEVLGVKLI 93

                          90       100
                  ....*....|....*....|..
gi 2593739819  81 VLCGHYGCGGVQAALSLPTLPL 102
Cdd:COG0288    94 VVLGHSGCGAVKAALDGLELEE 115
PRK10437 PRK10437
carbonic anhydrase; Provisional
 1-102 1.84e-45

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 147.00  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   1 WALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERV 80
Cdd:PRK10437   14 WSKMLVEEDPGFFEKLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNCLSVVQYAVDVLEVEHI 93

                          90       100
                  ....*....|....*....|..
gi 2593739819  81 VLCGHYGCGGVQAALSLPTLPL 102
Cdd:PRK10437   94 IICGHYGCGGVQAAVENPELGL 115
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 25-122 1.05e-42

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 138.03  E-value: 1.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819  25 LWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERVVLCGHYGCGGVQAALSLPtlPLAQ 104
Cdd:pfam00484   2 LIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAA--GPAE 79

                          90
                  ....*....|....*...
gi 2593739819 105 ESSALARRIGQLRHTLHH 122
Cdd:pfam00484  80 LPGFIDNWLRHIRPAVER 97
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 18-96 2.23e-41

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 134.55  E-value: 2.23e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2593739819   18 DGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERVVLCGHYGCGGVQAALS 96
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAALD 80
 
Name Accession Description Interval E-value
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 1-102 3.17e-56

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 173.14  E-value: 3.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   1 WALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERV 80
Cdd:cd00883     4 WAEEKKAKDPDFFPRLAKGQTPEYLWIGCSDSRVPENTILGLLPGEVFVHRNIANLVSPTDLNCLSVLQYAVDVLKVKHI 83

                          90       100
                  ....*....|....*....|..
gi 2593739819  81 VLCGHYGCGGVQAALSLPTLPL 102
Cdd:cd00883    84 IVCGHYGCGGVKAALTGKRLGL 105
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-102 1.37e-50

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 159.56  E-value: 1.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   1 WALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERV 80
Cdd:COG0288    14 FVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYDPGVLASIEYAVEVLGVKLI 93

                          90       100
                  ....*....|....*....|..
gi 2593739819  81 VLCGHYGCGGVQAALSLPTLPL 102
Cdd:COG0288    94 VVLGHSGCGAVKAALDGLELEE 115
PRK10437 PRK10437
carbonic anhydrase; Provisional
 1-102 1.84e-45

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 147.00  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   1 WALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERV 80
Cdd:PRK10437   14 WSKMLVEEDPGFFEKLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNCLSVVQYAVDVLEVEHI 93

                          90       100
                  ....*....|....*....|..
gi 2593739819  81 VLCGHYGCGGVQAALSLPTLPL 102
Cdd:PRK10437   94 IICGHYGCGGVQAAVENPELGL 115
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 25-122 1.05e-42

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 138.03  E-value: 1.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819  25 LWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERVVLCGHYGCGGVQAALSLPtlPLAQ 104
Cdd:pfam00484   2 LIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAA--GPAE 79

                          90
                  ....*....|....*...
gi 2593739819 105 ESSALARRIGQLRHTLHH 122
Cdd:pfam00484  80 LPGFIDNWLRHIRPAVER 97
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 18-96 2.23e-41

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 134.55  E-value: 2.23e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2593739819   18 DGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERVVLCGHYGCGGVQAALS 96
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAALD 80
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 20-97 1.25e-38

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 126.46  E-value: 1.25e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2593739819  20 QRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVMSVLQYALHYLEVERVVLCGHYGCGGVQAALSL 97
Cdd:cd00382     1 QKPKALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPPYDLDVLASLEYAVEVLGVKHIIVCGHTDCGAVKALVEE 78
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 4-101 3.73e-32

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 111.86  E-value: 3.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   4 QKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADDNVM-----SVLQYALHYLEVE 78
Cdd:cd00884     8 EYFPEERELFEKLAKGQSPKALFIACSDSRVVPALITQTQPGELFVVRNVGNLVPPYEPDGGfhgtsAAIEYAVAVLKVE 87

                          90       100
                  ....*....|....*....|...
gi 2593739819  79 RVVLCGHYGCGGVQAALSLPTLP 101
Cdd:cd00884    88 HIVVCGHSDCGGIRALLSPEDLL 110
PLN03014 PLN03014
carbonic anhydrase
 4-98 8.98e-19

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 80.16  E-value: 8.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   4 QKCQHDPDYFEKWVDGQRPHSLWIGCSDSRV-PAEVLTgSQPGELFVHRNIANMLDPADD----NVMSVLQYALHYLEVE 78
Cdd:PLN03014  142 EKYETNPALYGELAKGQSPKYMVFACSDSRVcPSHVLD-FQPGDAFVVRNIANMVPPFDKvkygGVGAAIEYAVLHLKVE 220

                          90       100
                  ....*....|....*....|
gi 2593739819  79 RVVLCGHYGCGGVQAALSLP 98
Cdd:PLN03014  221 NIVVIGHSACGGIKGLMSFP 240
PLN00416 PLN00416
carbonate dehydratase
 4-97 1.63e-18

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 78.54  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   4 QKCQHDPDYFEKWVDGQRPHSLWIGCSDSRV-PAEVLTgSQPGELFVHRNIANMLDPAD----DNVMSVLQYALHYLEVE 78
Cdd:PLN00416   62 EKYLKNSTLFNHLAKTQTPKFLVFACSDSRVcPSHILN-FQPGEAFVVRNIANMVPPFDqkrhSGVGAAVEYAVVHLKVE 140

                          90
                  ....*....|....*....
gi 2593739819  79 RVVLCGHYGCGGVQAALSL 97
Cdd:PLN00416  141 NILVIGHSCCGGIKGLMSI 159
PLN03019 PLN03019
carbonic anhydrase
 4-98 3.73e-17

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 75.57  E-value: 3.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   4 QKCQHDPDYFEKWVDGQRPHSLWIGCSDSRV-PAEVLTgSQPGELFVHRNIANMLDPADD----NVMSVLQYALHYLEVE 78
Cdd:PLN03019  137 EKYETNPALYGELAKGQSPKYMVFACSDSRVcPSHVLD-FHPGDAFVVRNIANMVPPFDKvkyaGVGAAIEYAVLHLKVE 215

                          90       100
                  ....*....|....*....|
gi 2593739819  79 RVVLCGHYGCGGVQAALSLP 98
Cdd:PLN03019  216 NIVVIGHSACGGIKGLMSFP 235
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 2-94 6.84e-17

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 71.79  E-value: 6.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   2 ALQKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMldpADDNVMSVLQYALHYLEVERVV 81
Cdd:cd03378    19 KPLHPDQDLARRRELAKGQKPFAVILSCSDSRVPPEIIFDQGLGDLFVVRVAGNI---VDDDVLGSLEYAVEVLGVPLVV 95

                          90
                  ....*....|...
gi 2593739819  82 LCGHYGCGGVQAA 94
Cdd:cd03378    96 VLGHESCGAVAAA 108
PLN02154 PLN02154
carbonic anhydrase
 4-96 2.05e-16

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 73.24  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   4 QKCQHDPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADD---NVMSVLQYALHYLEVERV 80
Cdd:PLN02154   89 QKYLPEIEKFKALAIAQSPKVMVIGCADSRVCPSYVLGFQPGEAFTIRNVANLVTPVQNgptETNSALEFAVTTLQVENI 168

                          90
                  ....*....|....*.
gi 2593739819  81 VLCGHYGCGGVQAALS 96
Cdd:PLN02154  169 IVMGHSNCGGIAALMS 184
PLN03006 PLN03006
carbonate dehydratase
 2-97 2.63e-16

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 72.85  E-value: 2.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819   2 ALQKCQH--DPDYFEKWVDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHRNIANMLDPADD---NVMSVLQYALHYLE 76
Cdd:PLN03006   91 AFKKLKYmdDFEHYKNLADAQAPKFLVIACADSRVCPSAVLGFQPGDAFTVRNIANLVPPYESgptETKAALEFSVNTLN 170

                          90       100
                  ....*....|....*....|.
gi 2593739819  77 VERVVLCGHYGCGGVQAALSL 97
Cdd:PLN03006  171 VENILVIGHSRCGGIQALMKM 191
PRK15219 PRK15219
carbonic anhydrase; Provisional
 17-95 4.75e-08

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 49.83  E-value: 4.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593739819  17 VDGQRPHSLWIGCSDSRVPAEVLTGSQPGELFVHR---NIANmldpadDNVMSVLQYALHYLEVERVVLCGHYGCGGVQA 93
Cdd:PRK15219   85 AAGQYPAAVILSCIDSRAPAEIILDTGIGETFNSRvagNISN------DDLLGSMEFACAVAGAKVVLVMGHTACGAVKG 158


                  ..
gi 2593739819  94 AL 95
Cdd:PRK15219  159 AI 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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