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Conserved domains on  [gi|2557378197|ref|WP_304441184|]
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carbonic anhydrase, partial [Cupriavidus sp. YR651]

Protein Classification

CynT family protein( domain architecture ID 10000966)

CynT family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
6-97 7.99e-26

Carbonic anhydrase [Inorganic ion transport and metabolism];


:

Pssm-ID: 440057  Cd Length: 204  Bit Score: 95.62  E-value: 7.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557378197   6 CLAHMPAVKSWLHHA-DAAKAVNEASAHASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAID 84
Cdd:COG0288   112 ELEELGLIGNWLRHIrPAVERVRAELPAADGEERLDRLVELNVREQVENLRTSPIVREAVAAGKLKVHGWVYDLATGRVE 191

                          90
                  ....*....|...
gi 2557378197  85 ALDGSTNTFVSLA 97
Cdd:COG0288   192 FLDPEGGGFEPLP 204
 
Name Accession Description Interval E-value
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
6-97 7.99e-26

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 95.62  E-value: 7.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557378197   6 CLAHMPAVKSWLHHA-DAAKAVNEASAHASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAID 84
Cdd:COG0288   112 ELEELGLIGNWLRHIrPAVERVRAELPAADGEERLDRLVELNVREQVENLRTSPIVREAVAAGKLKVHGWVYDLATGRVE 191

                          90
                  ....*....|...
gi 2557378197  85 ALDGSTNTFVSLA 97
Cdd:COG0288   192 FLDPEGGGFEPLP 204
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 4-86 8.72e-26

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 94.92  E-value: 8.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557378197   4 CKCLAHMPAVKSWLHHADAAKAVNEASA-HASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGA 82
Cdd:cd00884   107 EDLLDKLPFIGKWLRIAEPAKEVVLAELsHADFDDQLRALEKENVLLSLENLLTYPFVRERLEAGTLSLHGWYYDIETGE 186


                  ....
gi 2557378197  83 IDAL 86
Cdd:cd00884   187 LYAY 190
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 10-83 5.01e-20

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 79.48  E-value: 5.01e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2557378197  10 MPAVKSWLHHADAAKAVNEA--SAHASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAI 83
Cdd:pfam00484  81 PGFIDNWLRHIRPAVERVAEelESLDDPEERDDALEELNVREQVENLRTFPIVREAVAKGKLKIHGWVYDLETGEV 156
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 6-86 5.15e-18

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 74.08  E-value: 5.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557378197    6 CLAHMPAVKSWLHHADAAKAvneasAHASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAIDA 85
Cdd:smart00947  79 LDDEPGLIDNWLERIRPARE-----RALEELGDVDALEELNVRDQVENLRTSPAIREAVAKGKLKVHGWVYDIETGKLEV 153


                   .
gi 2557378197   86 L 86
Cdd:smart00947 154 L 154
 
Name Accession Description Interval E-value
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
6-97 7.99e-26

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 95.62  E-value: 7.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557378197   6 CLAHMPAVKSWLHHA-DAAKAVNEASAHASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAID 84
Cdd:COG0288   112 ELEELGLIGNWLRHIrPAVERVRAELPAADGEERLDRLVELNVREQVENLRTSPIVREAVAAGKLKVHGWVYDLATGRVE 191

                          90
                  ....*....|...
gi 2557378197  85 ALDGSTNTFVSLA 97
Cdd:COG0288   192 FLDPEGGGFEPLP 204
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 4-86 8.72e-26

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 94.92  E-value: 8.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557378197   4 CKCLAHMPAVKSWLHHADAAKAVNEASA-HASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGA 82
Cdd:cd00884   107 EDLLDKLPFIGKWLRIAEPAKEVVLAELsHADFDDQLRALEKENVLLSLENLLTYPFVRERLEAGTLSLHGWYYDIETGE 186


                  ....
gi 2557378197  83 IDAL 86
Cdd:cd00884   187 LYAY 190
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 10-83 5.01e-20

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 79.48  E-value: 5.01e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2557378197  10 MPAVKSWLHHADAAKAVNEA--SAHASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAI 83
Cdd:pfam00484  81 PGFIDNWLRHIRPAVERVAEelESLDDPEERDDALEELNVREQVENLRTFPIVREAVAKGKLKIHGWVYDLETGEV 156
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 6-86 5.15e-18

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 74.08  E-value: 5.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557378197    6 CLAHMPAVKSWLHHADAAKAvneasAHASTQARVNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAIDA 85
Cdd:smart00947  79 LDDEPGLIDNWLERIRPARE-----RALEELGDVDALEELNVRDQVENLRTSPAIREAVAKGKLKVHGWVYDIETGKLEV 153


                   .
gi 2557378197   86 L 86
Cdd:smart00947 154 L 154
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 39-86 3.06e-14

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 63.29  E-value: 3.06e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2557378197  39 VNSMVRENVIAQLANIKTHPAVALALEQGRLNLHGWLYDIETGAIDAL 86
Cdd:cd00382    72 VKALVEENVREQVENLRSHPLIQEAVAPGELKVHGWVYDIETGKLEVL 119
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 16-86 6.28e-13

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 61.43  E-value: 6.28e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2557378197  16 WLHHADAAKAVNEASAHA--STQARVNSMVRENVIAQLANIKTHPAVALALEQGR-LNLHGWLYDIETGAIDAL 86
Cdd:cd00883   109 WLRPIRDVYRLHAAELDAleDEEERVDRLVELNVVEQVKNLCKTPIVQDAWKRGQeLEVHGWVYDLGDGLLRDL 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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