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Conserved domains on  [gi|2538878769|ref|WP_295159755|]
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RnfABCDGE type electron transport complex subunit B [Selenomonas sp. AE3005]

Protein Classification

RnfABCDGE type electron transport complex subunit B( domain architecture ID 11482575)

RnfABCDGE type electron transport complex subunit B is part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
1-276 2.66e-89

Fe-S cluster domain-containing protein;


:

Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 266.41  E-value: 2.66e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   1 MEKAMMIIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEdPTVAPNLCVPGKA 80
Cdd:PRK07118    1 MNMILFAVLSLGALGLVFGILLAFASKKFAVEEDPRVEAVREVLPGANCGGCGYPGCDGYAEAVVN-GDAPPNLCPVGGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  81 AVAAKVAELTGKKAEVTEPKYAALKCRGTQTAAIMAAKYEGVPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMG 160
Cdd:PRK07118   80 EVAEKVAEILGKEAAESEPKVAVVRCQGTCDKAKERYEYQGIKDCAAAALLFGGPKGCSYGCLGLGSCVAACPFDAIHIE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 161 aDGLPVVDKDICTGCGKCVSTCPQAILTLKGFNDPVEVLCSSHDKGPAAKKLCQNACIGCGLCLRNCSQGAIKIDNFVAV 240
Cdd:PRK07118  160 -NGLPVVDEDKCTGCGACVKACPRNVIELIPKSARVFVACNSKDKGKAVKKVCEVGCIGCGKCVKACPAGAITMENNLAV 238

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2538878769 241 VDSSKCKDCpePTCLAKCPTGAIKALIDTAATQKTA 276
Cdd:PRK07118  239 IDQEKCTSC--GKCVEKCPTKAIRILNKPPKVKEPK 272
 
Name Accession Description Interval E-value
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
1-276 2.66e-89

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 266.41  E-value: 2.66e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   1 MEKAMMIIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEdPTVAPNLCVPGKA 80
Cdd:PRK07118    1 MNMILFAVLSLGALGLVFGILLAFASKKFAVEEDPRVEAVREVLPGANCGGCGYPGCDGYAEAVVN-GDAPPNLCPVGGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  81 AVAAKVAELTGKKAEVTEPKYAALKCRGTQTAAIMAAKYEGVPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMG 160
Cdd:PRK07118   80 EVAEKVAEILGKEAAESEPKVAVVRCQGTCDKAKERYEYQGIKDCAAAALLFGGPKGCSYGCLGLGSCVAACPFDAIHIE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 161 aDGLPVVDKDICTGCGKCVSTCPQAILTLKGFNDPVEVLCSSHDKGPAAKKLCQNACIGCGLCLRNCSQGAIKIDNFVAV 240
Cdd:PRK07118  160 -NGLPVVDEDKCTGCGACVKACPRNVIELIPKSARVFVACNSKDKGKAVKKVCEVGCIGCGKCVKACPAGAITMENNLAV 238

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2538878769 241 VDSSKCKDCpePTCLAKCPTGAIKALIDTAATQKTA 276
Cdd:PRK07118  239 IDQEKCTSC--GKCVEKCPTKAIRILNKPPKVKEPK 272
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 1-265 6.32e-75

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 229.11  E-value: 6.32e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   1 MEKAMMIIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEDpTVAPNLCVPGKA 80
Cdd:COG2878     1 MSTILIAVLVLGGLGLVFGLILGYASKKFKVEEDPRVEEIDALLPGANCGQCGYPGCRPYAEAIAEG-EAPINLCPPGGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  81 AVAAKVAELTGKKAEVTEPKYAALKCRGTQTAAIMAAKYEGVPDCAAAKLiqGGPKGCKYGCIGFGNCVKACPFGAMSMG 160
Cdd:COG2878    80 AVAEKLAELLGVEAGPLDPEVAVVRCNGGCEKAKPKYEYDGIKDCRAAVI--GGPKGCEYGCIGCGDCIKACPFDAIVGA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 161 ADGLPVVDKDICTGCGKCVSTCPQAILTLKgfNDPVEVLCSSHDKGPAAKKlcQNACIGCgLCLRNCSQGAIKIDNFVAV 240
Cdd:COG2878   158 AKGMHTVDEDKCTGCGLCVEACPVDCIEMV--PVSPTVVVSSWDKGKAVRK--VVGCIGL-CCKKCCPAAAITVNNLAAI 232

                         250       260
                  ....*....|....*....|....*
gi 2538878769 241 VDSSKCKDCPeptCLAKCPTGAIKA 265
Cdd:COG2878   233 IDYKKCTCCG---CCEKCCPTAIIA 254
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 135-264 1.60e-25

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 97.85  E-value: 1.60e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 135 PKGCKYGCIGFGNCVKACPFGAMSMGADGL----PVVDKDICTGCGKCVSTCPQAILTLKGFNDPVEVLCSShdkgpaaK 210
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIELGPNGAiargPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKE-------A 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 211 KLCQNACIGCGLCLRNCSQGAIKI-DNFVAVVDSSKCKDCPEptCLAKCPTGAIK 264
Cdd:cd10549    74 EIDEEKCIGCGLCVKVCPVDAITLeDELEIVIDKEKCIGCGI--CAEVCPVNAIK 126
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 7-183 1.55e-20

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 85.62  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   7 IIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEDPtvAPNLCVPGKAAVAAKV 86
Cdd:TIGR01944   5 AVAALSALGLALGAILGYAARRFPVEADPIVEEIDALLPQTQCGQCGYPGCRPYAEAIAEGE--AINKCPPGGEAVILAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  87 AELTGKKAEVTEPKYAALKCRGTQTAAIMAAKyegvpdcaaakliqggpkgckygCIGFGNCVKACPFGAMSMGADGLPV 166
Cdd:TIGR01944  83 AELLGVEPIPQPLDADAGTIQPPMVALIDEDN-----------------------CIGCTKCIQACPVDAIVGAAKAMHT 139

                         170
                  ....*....|....*..
gi 2538878769 167 VDKDICTGCGKCVSTCP 183
Cdd:TIGR01944 140 VIADECTGCDLCVEPCP 156
FeS pfam04060
Putative Fe-S cluster; This family includes a domain with four conserved cysteines that ...
 44-77 1.20e-04

Putative Fe-S cluster; This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.


Pssm-ID: 461150 [Multi-domain]  Cd Length: 33  Bit Score: 38.56  E-value: 1.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2538878769  44 LPKGQCGACGFAGCAKYAEAVVEDpTVAPNLCVP 77
Cdd:pfam04060   1 LPGTNCGACGYPGCRAFAEAVVAG-EAKINDCPP 33
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 215-263 1.56e-04

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 42.15  E-value: 1.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 215 NACIGCGLCLRNCSQGAIKIDNFVAVVdSSKCKDCpePTCLAKCPTGAI 263
Cdd:NF038196  185 DKCIGCGICAKVCPVNNIEMEDGKPVW-GHNCTHC--LACIHRCPKEAI 230
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 142-186 6.38e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 37.15  E-value: 6.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2538878769 142 CIGFGNCVKACPFGAMSMgADGLPVVDKDiCTGCGKCVSTCPQ-AI 186
Cdd:NF038196  187 CIGCGICAKVCPVNNIEM-EDGKPVWGHN-CTHCLACIHRCPKeAI 230
 
Name Accession Description Interval E-value
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
1-276 2.66e-89

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 266.41  E-value: 2.66e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   1 MEKAMMIIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEdPTVAPNLCVPGKA 80
Cdd:PRK07118    1 MNMILFAVLSLGALGLVFGILLAFASKKFAVEEDPRVEAVREVLPGANCGGCGYPGCDGYAEAVVN-GDAPPNLCPVGGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  81 AVAAKVAELTGKKAEVTEPKYAALKCRGTQTAAIMAAKYEGVPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMG 160
Cdd:PRK07118   80 EVAEKVAEILGKEAAESEPKVAVVRCQGTCDKAKERYEYQGIKDCAAAALLFGGPKGCSYGCLGLGSCVAACPFDAIHIE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 161 aDGLPVVDKDICTGCGKCVSTCPQAILTLKGFNDPVEVLCSSHDKGPAAKKLCQNACIGCGLCLRNCSQGAIKIDNFVAV 240
Cdd:PRK07118  160 -NGLPVVDEDKCTGCGACVKACPRNVIELIPKSARVFVACNSKDKGKAVKKVCEVGCIGCGKCVKACPAGAITMENNLAV 238

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2538878769 241 VDSSKCKDCpePTCLAKCPTGAIKALIDTAATQKTA 276
Cdd:PRK07118  239 IDQEKCTSC--GKCVEKCPTKAIRILNKPPKVKEPK 272
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 1-265 6.32e-75

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 229.11  E-value: 6.32e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   1 MEKAMMIIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEDpTVAPNLCVPGKA 80
Cdd:COG2878     1 MSTILIAVLVLGGLGLVFGLILGYASKKFKVEEDPRVEEIDALLPGANCGQCGYPGCRPYAEAIAEG-EAPINLCPPGGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  81 AVAAKVAELTGKKAEVTEPKYAALKCRGTQTAAIMAAKYEGVPDCAAAKLiqGGPKGCKYGCIGFGNCVKACPFGAMSMG 160
Cdd:COG2878    80 AVAEKLAELLGVEAGPLDPEVAVVRCNGGCEKAKPKYEYDGIKDCRAAVI--GGPKGCEYGCIGCGDCIKACPFDAIVGA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 161 ADGLPVVDKDICTGCGKCVSTCPQAILTLKgfNDPVEVLCSSHDKGPAAKKlcQNACIGCgLCLRNCSQGAIKIDNFVAV 240
Cdd:COG2878   158 AKGMHTVDEDKCTGCGLCVEACPVDCIEMV--PVSPTVVVSSWDKGKAVRK--VVGCIGL-CCKKCCPAAAITVNNLAAI 232

                         250       260
                  ....*....|....*....|....*
gi 2538878769 241 VDSSKCKDCPeptCLAKCPTGAIKA 265
Cdd:COG2878   233 IDYKKCTCCG---CCEKCCPTAIIA 254
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 135-264 1.60e-25

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 97.85  E-value: 1.60e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 135 PKGCKYGCIGFGNCVKACPFGAMSMGADGL----PVVDKDICTGCGKCVSTCPQAILTLKGFNDPVEVLCSShdkgpaaK 210
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIELGPNGAiargPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKE-------A 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 211 KLCQNACIGCGLCLRNCSQGAIKI-DNFVAVVDSSKCKDCPEptCLAKCPTGAIK 264
Cdd:cd10549    74 EIDEEKCIGCGLCVKVCPVDAITLeDELEIVIDKEKCIGCGI--CAEVCPVNAIK 126
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 7-183 1.55e-20

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 85.62  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   7 IIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEDPtvAPNLCVPGKAAVAAKV 86
Cdd:TIGR01944   5 AVAALSALGLALGAILGYAARRFPVEADPIVEEIDALLPQTQCGQCGYPGCRPYAEAIAEGE--AINKCPPGGEAVILAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  87 AELTGKKAEVTEPKYAALKCRGTQTAAIMAAKyegvpdcaaakliqggpkgckygCIGFGNCVKACPFGAMSMGADGLPV 166
Cdd:TIGR01944  83 AELLGVEPIPQPLDADAGTIQPPMVALIDEDN-----------------------CIGCTKCIQACPVDAIVGAAKAMHT 139

                         170
                  ....*....|....*..
gi 2538878769 167 VDKDICTGCGKCVSTCP 183
Cdd:TIGR01944 140 VIADECTGCDLCVEPCP 156
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 1-183 3.49e-19

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 82.69  E-value: 3.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   1 MEKAMMIIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEDPTVapNLCVPGKA 80
Cdd:PRK05113    1 MSAIWIAVAALSLLALVFGAILGFASRRFKVEGDPIVEKIDAILPQSQCGQCGYPGCRPYAEAIANGEKI--NKCPPGGE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  81 AVAAKVAELTGkkaevTEPKyaalkcrgtqtaAIMAAKYEGVPDCAAAKLIQGgpkgckyGCIGFGNCVKACPFGAMSMG 160
Cdd:PRK05113   79 ATMLKLAELLG-----VEPQ------------PLDGEAQEATPARKVAFIDED-------NCIGCTKCIQACPVDAIVGA 134

                         170       180
                  ....*....|....*....|...
gi 2538878769 161 ADGLPVVDKDICTGCGKCVSTCP 183
Cdd:PRK05113  135 TKAMHTVISDLCTGCDLCVAPCP 157
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
142-194 1.58e-12

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 67.19  E-value: 1.58e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTLKGFND 194
Cdd:COG1148   498 CTGCGRCVEVCPYGAISIDEKGVAEVNPALCKGCGTCAAACPSGAISLKGFTD 550
PRK06991 PRK06991
electron transport complex subunit RsxB;
31-183 4.42e-12

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 64.82  E-value: 4.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  31 MAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVeDPTVAPNLCVPGKAAVAAKVAELTGKKAEVTEPKyaalkcRGTQ 110
Cdd:PRK06991    2 TDSKTLADRIEDLLPQTQCTKCGYDGCRPYAEAIA-AGEANYNRCPPGGAEGIARLAALLGKPVIPLDPA------NGVE 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2538878769 111 TAAIMAAKYEGVpdcaaakliqggpkgckygCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:PRK06991   75 RPRAVAVIDEQL-------------------CIGCTLCMQACPVDAIVGAPKQMHTVLADLCTGCDLCVPPCP 128
PRK08764 PRK08764
Rnf electron transport complex subunit RnfB;
35-183 1.96e-11

Rnf electron transport complex subunit RnfB;


Pssm-ID: 181550 [Multi-domain]  Cd Length: 135  Bit Score: 60.32  E-value: 1.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  35 PLINEVEEILPKGQCGACGFAGCAKYAEAVVEDPTVApNLCVPGKAAVAAKVAELTGKkaevtePKYAALKCRGTQTAAI 114
Cdd:PRK08764    6 TLVERLDRLLPQTQCGQCGFDGCRPYAQAMARGEATI-DRCPPGGDAGARALAQVLGV------PARPYDRSRGTHKLPQ 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2538878769 115 MAAKYEGvpdcaaakliqggpkgckyGCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:PRK08764   79 VAWIVEA-------------------DCIGCTKCIQACPVDAIVGGAKHMHTVIAPLCTGCELCVPACP 128
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
214-264 2.69e-10

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 55.51  E-value: 2.69e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDNFVAVVDSSKCKDCPEptCLAKCPTGAIK 264
Cdd:COG2768    10 EEKCIGCGACVKVCPVGAISIEDGKAVIDPEKCIGCGA--CIEVCPVGAIK 58
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 142-264 3.20e-10

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 56.87  E-value: 3.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVD--KDICTGCGKCVSTCPQAILTLKGFND-PVEVLCSSHdkgpaakklCQN-AC 217
Cdd:cd10564    15 CTRCGDCVEACPEGIIVRGDGGFPELDfsRGECTFCGACAEACPEGALDPAREAPwPLRAEIGDS---------CLAlQG 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 218 IGCGLCLRNCSQGAIKI-----DNFVAVVDSSKCKDCPEptCLAKCPTGAIK 264
Cdd:cd10564    86 VECRSCQDACPTQAIRFrprlgGIALPELDADACTGCGA--CVSVCPVGAIT 135
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 142-190 5.46e-10

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 54.35  E-value: 5.46e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:COG1149    13 CIGCGLCVEVCPEGAIKLDDGGAPVVDPDLCTGCGACVGVCPTGAITLE 61
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 206-264 2.35e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 52.75  E-value: 2.35e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2538878769 206 GPAAKKLCQNACIGCGLCLRNCSQGAIKIDNFVAVVDSSKCKDCPEptCLAKCPTGAIK 264
Cdd:COG2221     6 GTWPPKIDEEKCIGCGLCVAVCPTGAISLDDGKLVIDEEKCIGCGA--CIRVCPTGAIK 62
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 142-190 2.76e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 52.36  E-value: 2.76e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 142 CIGFGNCVKACPFGAMSMgADGLPVVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:COG2221    17 CIGCGLCVAVCPTGAISL-DDGKLVIDEEKCIGCGACIRVCPTGAIKGE 64
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 139-190 2.79e-09

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 53.94  E-value: 2.79e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 139 KYGCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:cd10549    77 EEKCIGCGLCVKVCPVDAITLEDELEIVIDKEKCIGCGICAEVCPVNAIKLV 128
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
135-264 5.70e-09

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 56.19  E-value: 5.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 135 PKGCKYGCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTLKGFNDPVEVLCSSH---DKGPAAKK 211
Cdd:COG4624     8 CCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIiiiDKRGPSII 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2538878769 212 LCQNACIGCGLCLRNCSQGAIKIDNFVAVVDSSKCKDCPEptCLAKCPTGAIK 264
Cdd:COG4624    88 RDKEKCKNCYPCVRACPVKAIKVDDGKAEIDEEKCISCGQ--CVAVCPFGAIT 138
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
142-196 8.07e-09

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 51.27  E-value: 8.07e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 142 CIGFGNCVKACPFGAMSMGaDGLPVVDKDICTGCGKCVSTCPQAILTLKGFNDPV 196
Cdd:COG2768    13 CIGCGACVKVCPVGAISIE-DGKAVIDPEKCIGCGACIEVCPVGAIKIEWEEDEE 66
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 142-234 1.75e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 51.95  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPqailtlkgfndpvEVLCSSHDKGPAAKKlcqnaCIGCG 221
Cdd:cd16372    49 CNQCGECIDVCPTGAITRDANGVVMINKKLCVGCLMCVGFCP-------------EGAMFKHEDYPEPFK-----CIACG 110

                          90
                  ....*....|...
gi 2538878769 222 LCLRNCSQGAIKI 234
Cdd:cd16372   111 ICVKACPTGALEL 123
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 148-183 3.66e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 51.41  E-value: 3.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd16371    62 CVKVCPTGAITKREDGIVVVDQDKCIGCGYCVWACP 97
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 148-183 4.82e-08

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 51.87  E-value: 4.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:COG0437    68 CVKVCPTGATYKREDGIVLVDYDKCIGCRYCVAACP 103
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
214-263 4.88e-08

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 53.71  E-value: 4.88e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDN-FVAVVDSSKCKDCPepTCLAKCPTGAI 263
Cdd:COG1148   495 PEKCTGCGRCVEVCPYGAISIDEkGVAEVNPALCKGCG--TCAAACPSGAI 543
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 148-183 5.66e-08

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 50.47  E-value: 5.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd04410    58 CVKACPTGAIYKDEDGIVLIDEDKCIGCGSCVEACP 93
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
114-196 7.21e-08

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 53.11  E-value: 7.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 114 IMAAKYEGVPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMGaDGLPVVDKDICTGCGKCVSTCPQAILTLKGFN 193
Cdd:COG4624    65 CVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVD-DGKAEIDEEKCISCGQCVAVCPFGAITEKSDI 143


                  ...
gi 2538878769 194 DPV 196
Cdd:COG4624   144 EKV 146
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 142-190 1.02e-07

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 48.51  E-value: 1.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:COG1144    32 CIGCGLCWIVCPDGAIRVDDGKYYGIDYDYCKGCGICAEVCPVKAIEMV 80
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 165-235 1.54e-07

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 47.40  E-value: 1.54e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2538878769 165 PVVDKDICTGCGKCVSTCPQAILTLKgfndpvevlcsshDKGPAAKKLCQNACIGCGLCLRNCSQGAIKID 235
Cdd:COG1146     3 PVIDTDKCIGCGACVEVCPVDVLELD-------------EEGKKALVINPEECIGCGACELVCPVGAITVE 60
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 142-197 1.77e-07

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 47.43  E-value: 1.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGL---PVVDKDICTGCGKCVSTCPQAILTLKGFNDPVE 197
Cdd:COG1143     4 CIGCGLCVRVCPVDAITIEDGEPgkvYVIDPDKCIGCGLCVEVCPTGAISMTPFELAVE 62
PRK13795 PRK13795
hypothetical protein; Provisional
 140-183 1.85e-07

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 51.92  E-value: 1.85e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2538878769 140 YGCIGFGNCVKACPFGAMSMGADGLPV-VDKDICTGCGKCVSTCP 183
Cdd:PRK13795  581 AECVGCGVCVGACPTGAIRIEEGKRKIsVDEEKCIHCGKCTEVCP 625
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 165-239 2.09e-07

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 47.03  E-value: 2.09e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 165 PVVDKDICTGCGKCVSTCPQAILTLKGFNDPVevlcsshdkgpaakkLCQNACIGCGLCLRNCSQGAIKIDNFVA 239
Cdd:COG1149     6 PVIDEEKCIGCGLCVEVCPEGAIKLDDGGAPV---------------VDPDLCTGCGACVGVCPTGAITLEEREA 65
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 139-183 2.56e-07

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 49.22  E-value: 2.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2538878769 139 KYGCIGFGN--CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd10562    67 KRQCMHCTDaaCVKVCPTGALYKTENGAVVVDEDKCIGCGYCVAACP 113
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 165-236 2.70e-07

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 46.97  E-value: 2.70e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 165 PVVDKDICTGCGKCVSTCPQAILTLKGfnDPVEVLcsshdkgpaakklcQNACIGCGLCLRNCSQGAIKIDN 236
Cdd:COG2221    10 PKIDEEKCIGCGLCVAVCPTGAISLDD--GKLVID--------------EEKCIGCGACIRVCPTGAIKGEK 65
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 148-183 3.05e-07

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 49.45  E-value: 3.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd10551    61 CVKVCPTGATYKREDGIVLVDYDKCIGCRYCMAACP 96
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
161-236 3.80e-07

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 46.65  E-value: 3.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2538878769 161 ADGLPVVDKDICTGCGKCVSTCPQAILTLKgfNDPVEVlcsSHDKgpaakklcqnaCIGCGLCLRNCSQGAIKIDN 236
Cdd:COG2768     2 SLGKPYVDEEKCIGCGACVKVCPVGAISIE--DGKAVI---DPEK-----------CIGCGACIEVCPVGAIKIEW 61
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
122-241 4.52e-07

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 50.41  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 122 VPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP-QAILTLKGfndpvevlc 200
Cdd:COG4624    43 DDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPvKAIKVDDG--------- 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2538878769 201 sshdkgpaAKKLCQNACIGCGLCLRNCSQGAIKIDNFVAVV 241
Cdd:COG4624   114 --------KAEIDEEKCISCGQCVAVCPFGAITEKSDIEKV 146
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
148-236 4.77e-07

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 49.68  E-value: 4.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMS--MGADGL--PVVDKDICTGCGKCVSTCPQAIltlkgfndpvevlcsshDkgPAAKKLCQNACIGCGLC 223
Cdd:COG0348   184 CRYLCPYGAFQglLSDLSTlrVRYDRGDCIDCGLCVKVCPMGI-----------------D--IRKGEINQSECINCGRC 244

                          90
                  ....*....|...
gi 2538878769 224 LRNCSQGAIKIDN 236
Cdd:COG0348   245 IDACPKDAIRFSS 257
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 166-235 6.10e-07

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 46.19  E-value: 6.10e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 166 VVDKDICTGCGKCVSTCPqailtlkgfndpveVLCSSHDKGPAAKKlcQNACIGCGLCLRNCSQGAIKID 235
Cdd:COG4231    18 VIDEDKCTGCGACVKVCP--------------ADAIEEGDGKAVID--PDLCIGCGSCVQVCPVDAIKLE 71
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 142-184 9.71e-07

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 45.42  E-value: 9.71e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2538878769 142 CIGFGNCVKACPFGAMSMGaDGLPVVDKDICTGCGKCVSTCPQ 184
Cdd:COG4231    24 CTGCGACVKVCPADAIEEG-DGKAVIDPDLCIGCGSCVQVCPV 65
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 142-186 1.24e-06

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 45.09  E-value: 1.24e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLP--VVDKDICTGCGKCVSTCP-QAI 186
Cdd:COG1146    10 CIGCGACVEVCPVDVLELDEEGKKalVINPEECIGCGACELVCPvGAI 57
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 166-264 1.86e-06

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 46.23  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 166 VVDKDICTGCGKCVSTCPQA--------------ILTLKGFNDPVEVLCSsHDKGPAAKKLC----------------QN 215
Cdd:cd04410     2 VVDLDRCIGCGTCEVACKQEhglrpgpdwsrikvIEGGGLERAFLPVSCM-HCEDPPCVKACptgaiykdedgivlidED 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2538878769 216 ACIGCGLCLRNCSQGAIKIDNfvAVVDSSKCKDCPE-------PTCLAKCPTGAIK 264
Cdd:cd04410    81 KCIGCGSCVEACPYGAIVFDP--EPGKAVKCDLCGDrldeglePACVKACPTGALT 134
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 148-234 1.93e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 46.03  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMSMGAD-GLPVVDKDICTGCGKCVSTCPQAILTLkgfndpvevlcsSHDKGPAAKklCqNACIGCGLCLRN 226
Cdd:cd10550    57 CVEACPVGAISRDEEtGAVVVDEDKCIGCGMCVEACPFGAIRV------------DPETGKAIK--C-DLCGGDPACVKV 121


                  ....*...
gi 2538878769 227 CSQGAIKI 234
Cdd:cd10550   122 CPTGALEF 129
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 214-264 2.34e-06

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 44.65  E-value: 2.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDNFVAVVDSSKCKDCpePTCLAKCPTGAIK 264
Cdd:COG4231    21 EDKCTGCGACVKVCPADAIEEGDGKAVIDPDLCIGC--GSCVQVCPVDAIK 69
PRK09898 PRK09898
ferredoxin-like protein;
148-234 2.43e-06

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 47.14  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMSMGAD-GLPVVDKDICTGCGKCVSTCPQAILTLKgfndpvevlcsshdkgPAAKKlcQNACIGCGLCLRN 226
Cdd:PRK09898  131 CMNVCPIGAITWQQKeGCITVDHKRCIGCSACTTACPWMMATVN----------------TESKK--SSKCVLCGECANA 192


                  ....*...
gi 2538878769 227 CSQGAIKI 234
Cdd:PRK09898  193 CPTGALKI 200
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 148-264 2.69e-06

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 47.38  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCpqailtlkgfndPVEVLCSSHDKGPAAKklcqnacigCGLCLrnc 227
Cdd:cd10560    86 CLEACPTGAIFRTEFGTVYIQPDICNGCGYCVAAC------------PFGVIDRNEETGRAHK---------CTLCY--- 141

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2538878769 228 sqgaikidnfvavvdsSKCKDCPEPTCLAKCPTGAIK 264
Cdd:cd10560   142 ----------------DRLKDGLEPACAKACPTGSIQ 162
NapF COG1145
Ferredoxin [Energy production and conversion];
2-190 2.88e-06

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 47.41  E-value: 2.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   2 EKAMMIIVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEDPTVAPNLCVPGKAA 81
Cdd:COG1145    44 LGGLLPIIGILAKEAFDALKDVLGILGAIVIGIGAGEIVRVGIAAADLNLKAVALVLLLALAVAGAAKRLIISAVKLVAG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  82 VAAKVAELTGKKAEVTEPKYAALKCRGTQTAAIMAAKYEGVPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMGA 161
Cdd:COG1145   124 LVVAAGEVLLVIAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKD 203

                         170       180       190
                  ....*....|....*....|....*....|
gi 2538878769 162 DGLP-VVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:COG1145   204 GKPQiVVDPDKCIGCGACVKVCPVGAISLE 233
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 214-264 3.30e-06

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 43.95  E-value: 3.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDN-FVAVVDSSKCKDCpePTCLAKCPTGAIK 264
Cdd:COG1149    10 EEKCIGCGLCVEVCPEGAIKLDDgGAPVVDPDLCTGC--GACVGVCPTGAIT 59
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
165-237 3.60e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 47.93  E-value: 3.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 165 PVVDKDICTGCGKCVSTCP-QAI-LTLKGFNDPVEVLCSshdkgpaakklcqnaciGCGLCLRNCSQGAIKIDNF 237
Cdd:COG1148   491 AEVDPEKCTGCGRCVEVCPyGAIsIDEKGVAEVNPALCK-----------------GCGTCAAACPSGAISLKGF 548
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 139-264 4.24e-06

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 46.61  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 139 KYGCIGFGN--CVKACP-FGAMSMGADGLPVVDKDICTGCGKCVSTCPqailtlkgFNDPVevlcSSHDKGPAAKklcqn 215
Cdd:cd10558    67 KDGCMHCADpgCLKACPsPGAIVQYANGIVDFQSDKCIGCGYCIKGCP--------FDIPR----ISKDDNKMYK----- 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 216 acigCGLCLRNCSQGAikidnfvavvdsskckdcpEPTCLAKCPTGAIK 264
Cdd:cd10558   130 ----CTLCSDRVSVGL-------------------EPACVKTCPTGALH 155
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 142-264 6.14e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 44.99  E-value: 6.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACP---FGAMSMGADGLPVVDKDICTGCGKCVstcpqailtlkgfnDPVEVLCSSHD---KGPAAKKLCQN 215
Cdd:cd16367    21 CIRCDNCEKACAdthDGHSRLDRNGLRFGNLLVPTACRHCV--------------DPVCMIGCPTGaihRDDGGEVVISD 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 216 ACIGCGLCLRNCSQGAIKIdnfvavVDSSKCKDCP---EPTCLAKCPTGAIK 264
Cdd:cd16367    87 ACCGCGNCASACPYGAIQM------VRAVKCDLCAgyaGPACVSACPTGAAI 132
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 146-183 6.88e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 44.94  E-value: 6.88e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2538878769 146 GNCVKACPFGAMSM---GADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd16373   103 GVCVEACPTEAIAIvleDDVLRPVVDEDKCVGCGLCEYVCP 143
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 148-232 6.90e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 44.57  E-value: 6.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP-QAILTLKGFNDPVevlcsshdkgpaakklcqnACIGCGLCLRN 226
Cdd:cd16370    61 CAEACPTGALEPRKGGGVVLDKEKCIGCGNCVKACIvGAIFWDEETNKPI-------------------ICIHCGYCARY 121


                  ....*.
gi 2538878769 227 CSQGAI 232
Cdd:cd16370   122 CPHDVL 127
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
142-264 1.04e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 44.26  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADG----LPVVDKD------ICTGC--GKCVSTCP-QAIltlkgfndpvevlcsSHDKGpa 208
Cdd:COG1142    12 CIGCRTCEAACAVAHEGEEGEPflprIRVVRKAgvsapvQCRHCedAPCAEVCPvGAI---------------TRDDG-- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 209 AKKLCQNACIGCGLCLRNCSQGAIKIDNFVAVVDSSKCKDCPE----PTCLAKCPTGAIK 264
Cdd:COG1142    75 AVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAVAVKCDLCGGreggPACVEACPTGALR 134
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 142-190 1.21e-05

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 45.45  E-value: 1.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPvVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:cd03110    66 CIRCGNCERVCKFGAILEFFQKLI-VDESLCEGCGACVIICPRGAIYLK 113
PRK13795 PRK13795
hypothetical protein; Provisional
 217-259 1.83e-05

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 45.76  E-value: 1.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2538878769 217 CIGCGLCLRNCSQGAIKIDNFVA--VVDSSKCKDCPEptCLAKCP 259
Cdd:PRK13795  583 CVGCGVCVGACPTGAIRIEEGKRkiSVDEEKCIHCGK--CTEVCP 625
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 142-187 1.98e-05

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 42.63  E-value: 1.98e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVV--DKDICTGCGKCVSTCPQAIL 187
Cdd:TIGR00402  36 CTRCGECASACENNILQLGQQGQPTVefDNAECDFCGKCAEACPTNAF 83
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 148-186 2.03e-05

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 43.51  E-value: 2.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMSM-GADGLPVVDKDICTGCGKCVSTCPQAI 186
Cdd:cd10553    66 CVKACPTGAMQKrEKDGIVYVDQELCIGCKACIEACPWGI 105
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 165-234 2.66e-05

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 41.58  E-value: 2.66e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 165 PVVDKDICTGCGKCVSTCPQAILTLKGFNDPVEVLcsshdkgpaakklcqNACIGCGLCLRNCSQGAIKI 234
Cdd:COG1144    25 PVVDEDKCIGCGLCWIVCPDGAIRVDDGKYYGIDY---------------DYCKGCGICAEVCPVKAIEM 79
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
147-183 2.94e-05

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 44.66  E-value: 2.94e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2538878769 147 NCVKACPFGAMSMGA-DGLPVVDKDICTGCGKCVSTCP 183
Cdd:PRK10882  119 NCVSVCPVSALTKDPkTGIVHYDKDVCTGCRYCMVACP 156
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 148-183 3.95e-05

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 42.77  E-value: 3.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd16366    78 CLAACPTGAIIRTETGTVVVDPETCIGCGYCVNACP 113
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 135-186 3.96e-05

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 44.78  E-value: 3.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2538878769 135 PKGCKYGCIGFgncvkaCPF-----GAMSMG-ADGLPVVDKDICTGCGKCVSTCP-QAI 186
Cdd:COG1245    14 PKKCNYECIKY------CPVnrtgkEAIEIDeDDGKPVISEELCIGCGICVKKCPfDAI 66
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 214-264 5.39e-05

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 40.81  E-value: 5.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDN-FVAVVDSSKCKDCpePTCLAKCPTGAIK 264
Cdd:COG1144    29 EDKCIGCGLCWIVCPDGAIRVDDgKYYGIDYDYCKGC--GICAEVCPVKAIE 78
NapF COG1145
Ferredoxin [Energy production and conversion];
8-234 5.74e-05

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 43.56  E-value: 5.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769   8 IVVLVGVGLFFGIVLALADKKFYMAVNPLINEVEEILPKGQCGACGFAGCAKYAEAVVEDPTVAPNLCVPGKAAVAAKVA 87
Cdd:COG1145    20 AVVTGILGKIILNVIAGALLKAVALGGLLPIIGILAKEAFDALKDVLGILGAIVIGIGAGEIVRVGIAAADLNLKAVALV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769  88 ELTGKKAEVTEPKYAALKCRGTQTAAIMAAKYEGVPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMGADGLPVV 167
Cdd:COG1145   100 LLLALAVAGAAKRLIISAVKLVAGLVVAAGEVLLVIAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVI 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2538878769 168 DKDICTGCGKCVSTCPQAILTLKGFNDPVEVLcsshdkgpaakklcQNACIGCGLCLRNCSQGAIKI 234
Cdd:COG1145   180 DAEKCIGCGLCVKVCPTGAIRLKDGKPQIVVD--------------PDKCIGCGACVKVCPVGAISL 232
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
135-186 5.87e-05

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 44.03  E-value: 5.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2538878769 135 PKGCKYGCIGFgncvkaCPFGAMS------MGADGLPVVDKDICTGCGKCVSTCP-QAI 186
Cdd:PRK13409   14 PKKCNYECIKY------CPVVRTGeetieiDEDDGKPVISEELCIGCGICVKKCPfDAI 66
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 148-186 5.90e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 43.18  E-value: 5.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAI 186
Cdd:cd16368    99 CAKLCPFGAARKTPEGAVYIDDDLCFGGAKCRDVCPWHI 137
RNAP_D cd07030
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ...
 164-243 6.38e-05

D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer.


Pssm-ID: 132908 [Multi-domain]  Cd Length: 259  Bit Score: 43.41  E-value: 6.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 164 LPVV--DKDiCTGCGKCVSTCPQAILTLKGFNDPVEVLCSshdkgpaakklcqnaCIGCGLCLRNCSQGAIKI----DNF 237
Cdd:cd07030   162 YPVIeiDED-CDGCGKCVEECPRGVLELEEGKVVVEDLED---------------CSLCKLCERACDAGAIRVgwdeDRF 225


                  ....*.
gi 2538878769 238 VAVVDS 243
Cdd:cd07030   226 IFEVES 231
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 142-183 1.02e-04

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 42.24  E-value: 1.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGlPVVDKdiCTGCGK---------CVSTCP 183
Cdd:COG0437    92 CIGCRYCVAACPYGAPRFNPET-GVVEK--CTFCADrldegllpaCVEACP 139
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 142-190 1.15e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 40.78  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 142 CIGFGNCVKACPFGAMSMgADGLPVVDKdiCTGCGKCVSTCPQAILTLK 190
Cdd:cd16372    79 CVGCLMCVGFCPEGAMFK-HEDYPEPFK--CIACGICVKACPTGALELV 124
FeS pfam04060
Putative Fe-S cluster; This family includes a domain with four conserved cysteines that ...
 44-77 1.20e-04

Putative Fe-S cluster; This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.


Pssm-ID: 461150 [Multi-domain]  Cd Length: 33  Bit Score: 38.56  E-value: 1.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2538878769  44 LPKGQCGACGFAGCAKYAEAVVEDpTVAPNLCVP 77
Cdd:pfam04060   1 LPGTNCGACGYPGCRAFAEAVVAG-EAKINDCPP 33
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 214-264 1.33e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 39.34  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDN----FVAVVDSSKCKDCpePTCLAKCPTGAIK 264
Cdd:COG1143     1 EDKCIGCGLCVRVCPVDAITIEDgepgKVYVIDPDKCIGC--GLCVEVCPTGAIS 53
PRK13795 PRK13795
hypothetical protein; Provisional
 171-227 1.45e-04

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 43.06  E-value: 1.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2538878769 171 ICTGCGKCVSTCPQAILTLKGFNDPVEVLCSShdkgpaakklcqnaCIGCGLCLRNC 227
Cdd:PRK13795  582 ECVGCGVCVGACPTGAIRIEEGKRKISVDEEK--------------CIHCGKCTEVC 624
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 142-183 1.54e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 40.64  E-value: 1.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd10550    82 CIGCGMCVEACPFGAIRVDPETGKAIKCDLCGGDPACVKVCP 123
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 215-263 1.56e-04

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 42.15  E-value: 1.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 215 NACIGCGLCLRNCSQGAIKIDNFVAVVdSSKCKDCpePTCLAKCPTGAI 263
Cdd:NF038196  185 DKCIGCGICAKVCPVNNIEMEDGKPVW-GHNCTHC--LACIHRCPKEAI 230
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 148-263 1.67e-04

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 40.70  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMSM-GADGLPVVDKDICTGCGKCVSTCPQailtlkgfndpvevlcsshdkgpaakklcqnacigcglclrn 226
Cdd:cd10563    65 CVKACMSGAMHKdPETGIVIHDEEKCVGCWMCVMVCPY------------------------------------------ 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2538878769 227 csqGAIKIDNFVAVVdsSKCKDCPE---PTCLAKCPTGAI 263
Cdd:cd10563   103 ---GAIRPDKERKVA--LKCDLCPDretPACVEACPTGAL 137
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 167-243 1.72e-04

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 42.18  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 167 VDKDiCTGCGKCVSTCPQAILTLKG----FNDPVEvlcsshdkgpaakklcqnaCIGCGLCLRNCSQGAIKI----DNFV 238
Cdd:PRK00783  167 VSED-CDECEKCVEACPRGVLELKEgklvVTDLLN-------------------CSLCKLCERACPGKAIRVsddeNKFI 226


                  ....*
gi 2538878769 239 AVVDS 243
Cdd:PRK00783  227 FTVES 231
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 135-183 1.98e-04

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 40.01  E-value: 1.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2538878769 135 PKGCKYGCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:PRK09624   46 PEFNRDKCVRCYLCYIYCPEPAIYLDEEGYPVFDYDYCKGCGICANECP 94
NarH_beta-like cd10557
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ...
 148-183 2.00e-04

beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli.


Pssm-ID: 319879 [Multi-domain]  Cd Length: 363  Bit Score: 42.35  E-value: 2.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2538878769 148 CVKACPFGAM-SMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd10557   187 CVAACPSGAIyKREEDGIVLIDQDRCRGWRMCVSACP 223
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 169-237 2.11e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 38.57  E-value: 2.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2538878769 169 KDICTGCGKCVSTCPQAILTLKGfndpvevlcsshDKGPAAKKLCQNACIGCGLCLRNCSQGAIKIDNF 237
Cdd:COG1143     1 EDKCIGCGLCVRVCPVDAITIED------------GEPGKVYVIDPDKCIGCGLCVEVCPTGAISMTPF 57
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
142-190 2.54e-04

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 41.59  E-value: 2.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACPfgamsMGAD-GLPVVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:COG0348   212 CIDCGLCVKVCP-----MGIDiRKGEINQSECINCGRCIDACPKDAIRFS 256
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 148-190 2.71e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 40.34  E-value: 2.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTLK 190
Cdd:cd16374    51 CMEVCPTGAIYRDEDGAVLVDPDKCIGCGMCAMACPFGVPRFD 93
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
142-189 2.90e-04

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 39.54  E-value: 2.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTL 189
Cdd:PRK09623   53 CVKCYICWKFCPEPAIYIKEDGYVAIDYDYCKGCGICANECPTKAITM 100
NapF COG1145
Ferredoxin [Energy production and conversion];
105-264 3.11e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 41.25  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 105 KCRGTQTAAIMAAKYEGVPDCAAAKLIQGGPKGCKYGCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQ 184
Cdd:COG1145    75 GIGAGEIVRVGIAAADLNLKAVALVLLLALAVAGAAKRLIISAVKLVAGLVVAAGEVLLVIAAALAEAGLAILGAAAPVD 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 185 AILTLKGFNDPVEVLcssHDKGPAAKKLCQNACIGCGLCLRNCSQGAIKI--DNFVAVVDSSKCKDCPEptCLAKCPTGA 262
Cdd:COG1145   155 ALAISGGKKIEEELK---IAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLkdGKPQIVVDPDKCIGCGA--CVKVCPVGA 229


                  ..
gi 2538878769 263 IK 264
Cdd:COG1145   230 IS 231
Fer4_9 pfam13187
4Fe-4S dicluster domain;
142-184 3.24e-04

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 37.92  E-value: 3.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVV---DKDICTGCGKCVSTCPQ 184
Cdd:pfam13187   2 CTGCGACVAACPAGAIVPDLVGQTIRgdiAGLACIGCGACVDACPR 47
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 142-183 3.47e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 38.00  E-value: 3.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDI------CTGCGKCVSTCP 183
Cdd:pfam13237   9 CIGCGRCTAACPAGLTRVGAIVERLEGEAVrigvwkCIGCGACVEACP 56
Fer4_21 pfam14697
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 142-183 3.51e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 434137 [Multi-domain]  Cd Length: 59  Bit Score: 38.03  E-value: 3.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2538878769 142 CIGFGNCVKACPFG---AMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:pfam14697   8 CIGCGKCYIACPDTshqAIVGDGKRHHTVIEDECTGCNLCVSVCP 52
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 142-274 3.56e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 41.94  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACpfgAMSMGADGLPVVDKDI-----------------CTGCGK--CVSTCPQAILTLKgfNDPVEvlcss 202
Cdd:PRK12809   12 CIGCHACEIAC---AVAHNQENWPLSHSDFrprihvvgkgqaanpvaCHHCNNapCVTACPVNALTFQ--SDSVQ----- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2538878769 203 hdkgpaakkLCQNACIGCGLCLRNCSQGAIK-IDNFVAVVDSSKCKDCPEPTCLAKCPTGAIKaLIDTAATQK 274
Cdd:PRK12809   82 ---------LDEQKCIGCKRCAIACPFGVVEmVDTIAQKCDLCNQRSSGTQACIEVCPTQALR-LMDDKGLQQ 144
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 141-194 3.60e-04

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 39.73  E-value: 3.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2538878769 141 GCIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCPQAILTLKGFND 194
Cdd:PRK09625   60 ICINCFNCWVYCPDAAILSRDKKLKGVDYSHCKGCGVCVEVCPTNPKSLLMFEE 113
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 214-264 3.75e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 39.57  E-value: 3.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDNFVAVVDssKCKDCPE-------PTCLAKCPTGAIK 264
Cdd:cd16374    72 PDKCIGCGMCAMACPFGVPRFDPSLKVAV--KCDLCIDrrregklPACVEACPTGALK 127
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 142-189 3.90e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 39.68  E-value: 3.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVdkdICTGCGK---------CVSTCPQAILTL 189
Cdd:cd04410    82 CIGCGSCVEACPYGAIVFDPEPGKAV---KCDLCGDrldeglepaCVKACPTGALTF 135
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 142-190 4.03e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 39.56  E-value: 4.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACPFGAMSMGAD-GLPVvdkdICTGCGKCVSTCPQAILTLK 190
Cdd:cd16370    85 CIGCGNCVKACIVGAIFWDEEtNKPI----ICIHCGYCARYCPHDVLAME 130
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 148-183 4.48e-04

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 40.27  E-value: 4.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:cd10561    77 CVSACPVGALRKTPEGPVTYDEDKCIGCRYCMVACP 112
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 142-186 4.49e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 37.51  E-value: 4.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLP------VVDKDICTGCGKCVSTCPQAI 186
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKkgtktvVIDPERCVGCGACVAVCPTGA 51
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 142-186 5.34e-04

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 41.24  E-value: 5.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2538878769 142 CIGFGNCVKACPFG-----AMSMGADG--LPVVD-KDICTGCGKCVSTCPQAI 186
Cdd:cd01916   367 CTDCGWCTRACPNSlrikeAMEAAKEGdfSGLADlFDQCVGCGRCEQECPKEI 419
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 164-239 5.62e-04

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 40.45  E-value: 5.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2538878769 164 LPVVDKDICTGCGKCVSTCP-QAILTLKGFNDPVEVLCSshdkgpaakklcqnaciGCGLCLRNCSQGAIKIDNFVA 239
Cdd:cd03110    58 KAFIDQEKCIRCGNCERVCKfGAILEFFQKLIVDESLCE-----------------GCGACVIICPRGAIYLKDRDT 117
PRK09326 PRK09326
F420H2 dehydrogenase subunit F; Provisional
 164-227 6.62e-04

F420H2 dehydrogenase subunit F; Provisional


Pssm-ID: 181779 [Multi-domain]  Cd Length: 341  Bit Score: 40.59  E-value: 6.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2538878769 164 LPVVDKDICTGCGKCVSTCPQAILTLK---GFNDPVEVLCSSHDKGPaakklcqNACIGCGLCLRNC 227
Cdd:PRK09326    6 AEVIEYDVCTACGACEAVCPIGAITVDkkaEIRDPNDLELYEKGAAP-------NVCEGCLTCSRIC 65
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 217-262 7.64e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 36.74  E-value: 7.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2538878769 217 CIGCGLCLRNCSQGAIKID-------NFVAVVDSSKCKDCPEptCLAKCPTGA 262
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDevgekkgTKTVVIDPERCVGCGA--CVAVCPTGA 51
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
148-183 7.98e-04

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 39.86  E-value: 7.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2538878769 148 CVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:PRK14993  108 CVPVCPVQATFQREDGIVVVDNKRCVGCAYCVQACP 143
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
142-189 8.48e-04

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 38.87  E-value: 8.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2538878769 142 CIGFGNCVKACPFGAMSM-GADGLPVVDK-DICTGC---GKCVSTCPQAILTL 189
Cdd:COG1142    83 CIGCGLCVLACPFGAITMvGEKSRAVAVKcDLCGGReggPACVEACPTGALRL 135
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 171-264 1.01e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 38.33  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 171 ICTGCGK--CVSTCPQ-AIltlkgfndpvevlcsSHDKGPAAKKLCQNACIGCGLCLRNCSQGAIKIDNFVAVVdsSKCK 247
Cdd:cd10550    48 VCRQCEDapCVEACPVgAI---------------SRDEETGAVVVDEDKCIGCGMCVEACPFGAIRVDPETGKA--IKCD 110

                          90
                  ....*....|....*...
gi 2538878769 248 DCP-EPTCLAKCPTGAIK 264
Cdd:cd10550   111 LCGgDPACVKVCPTGALE 128
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 162-232 1.09e-03

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 37.78  E-value: 1.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 162 DGLPV-VDKDICTGCGKCVSTCPQAILTLKgfNDPVEVLcsshdkGPAAKKLCQNACIGCGLCLRNCSQGAI 232
Cdd:PRK09626    7 DNTPVwVDESRCKACDICVSVCPAGVLAMR--IDPHAVL------GKMIKVVHPESCIGCRECELHCPDFAI 70
PRK13984 PRK13984
putative oxidoreductase; Provisional
 142-189 1.24e-03

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 40.14  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2538878769 142 CIGFGNCVKACPFGAMSM-------GADGL----PVVDKDICTGCGKCVSTCPQAILTL 189
Cdd:PRK13984   47 CIGCGTCSKICPTDAITMvevpdlpQEYGKkpqrPVIDYGRCSFCALCVDICTTGSLKM 105
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 142-189 1.51e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 39.73  E-value: 1.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2538878769 142 CIGFGNCVKACPFGAMSM----GADGLPVVDKDICTGCG------KCVSTCPQAILTL 189
Cdd:PRK12769   87 CIGCKSCVVACPFGTMQIvltpVAAGKVKATAHKCDLCAgrengpACVENCPADALQL 144
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
169-234 1.63e-03

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 39.42  E-value: 1.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2538878769 169 KDICTGCGKCVStCPQAI---LTLKGFNdpvevLCSSHDKGPAAKKLCQ--------NACIGCGLCLRNCSQGaIKI 234
Cdd:COG1453   280 KDFCTGCGYCMP-CPQGInipEVFRLYN-----LARAYGMREYAKERYNalgpgakaSACIECGACEERCPQG-LDI 349
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 214-264 1.93e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 36.23  E-value: 1.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2538878769 214 QNACIGCGLCLRNCSQGAIKIDN---FVAVVDSSKCKDCpePTCLAKCPTGAIK 264
Cdd:COG1146     7 TDKCIGCGACVEVCPVDVLELDEegkKALVINPEECIGC--GACELVCPVGAIT 58
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 148-234 2.30e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 37.62  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 148 CVKACPFGAMSMGAD-------GLPVVDKDIC------TGCGKCVSTCPQ---AILTLKGFNDPVEVLcsshdkgpaakk 211
Cdd:cd16373    62 CVEVCPTGALRPLDLeeqkvkmGVAVIDKDRClawqggTDCGVCVEACPTeaiAIVLEDDVLRPVVDE------------ 129

                          90       100
                  ....*....|....*....|....*.
gi 2538878769 212 lcqNACIGCGLCLRNC---SQGAIKI 234
Cdd:cd16373   130 ---DKCVGCGLCEYVCpvePPKAIVV 152
PRK10194 PRK10194
ferredoxin-type protein NapF;
142-265 2.43e-03

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 37.70  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVD--KDICTGCGKCVSTCPQAILTLKgFNDPVEVLCSSHDKGPAAKKL----CQN 215
Cdd:PRK10194   36 CTRCDACINACENNILQRGAGGYPSVNfkNNECSFCYACAQACPESLFSPR-HTRAWDLQFTIGDACLAYQSVecrrCQD 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2538878769 216 ACIGCGLCLRNCSQGAikidnFVAVVDSSKCKDCpePTCLAKCPTGAIKA 265
Cdd:PRK10194  115 SCEPMAIIFRPTLSGI-----YQPQLNSQLCNGC--GACAASCPVSAITA 157
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 142-183 2.64e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 38.33  E-value: 2.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDKDICTGCGKCVSTCP 183
Cdd:PRK00783  171 CDECEKCVEACPRGVLELKEGKLVVTDLLNCSLCKLCERACP 212
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 142-189 2.90e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 37.16  E-value: 2.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGlPVVDKdiCTGC------GK---CVSTCPQAILTL 189
Cdd:cd16371    86 CIGCGYCVWACPYGAPQYNPET-GKMDK--CDMCvdrldeGEkpaCVAACPTRALDF 139
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 170-263 4.19e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 36.84  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 170 DICTGCGKCVSTCPQAILTLkgfndpvevlcssHDKGPAAKKLCQNACIGCGLCLRNCSQGAIKIDN-----FVAVVDSS 244
Cdd:cd10564    13 DLCTRCGDCVEACPEGIIVR-------------GDGGFPELDFSRGECTFCGACAEACPEGALDPAReapwpLRAEIGDS 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 2538878769 245 kckdcpeptCLAK-----------CPTGAI 263
Cdd:cd10564    80 ---------CLALqgvecrscqdaCPTQAI 100
CdhE COG1456
CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production ...
 31-65 4.97e-03

CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion];


Pssm-ID: 441065 [Multi-domain]  Cd Length: 442  Bit Score: 38.08  E-value: 4.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2538878769  31 MAVNPLinEVEEILPKGQCGACGFAGCAKYAEAVV 65
Cdd:COG1456     1 MALTPL--EIYKLLPKTNCKECGEPTCMAFAMKLA 33
PRK09898 PRK09898
ferredoxin-like protein;
170-264 6.23e-03

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 37.12  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 170 DICTGCG--KCVSTCPQAILTLKgfndpvevlcsshdKGPAAKKLCQNACIGCGLCLRNCSQGAIKIDNfvAVVDSSKCK 247
Cdd:PRK09898  121 DTCRQCKepQCMNVCPIGAITWQ--------------QKEGCITVDHKRCIGCSACTTACPWMMATVNT--ESKKSSKCV 184

                          90
                  ....*....|....*..
gi 2538878769 248 DCPEptCLAKCPTGAIK 264
Cdd:PRK09898  185 LCGE--CANACPTGALK 199
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 142-186 6.38e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 37.15  E-value: 6.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2538878769 142 CIGFGNCVKACPFGAMSMgADGLPVVDKDiCTGCGKCVSTCPQ-AI 186
Cdd:NF038196  187 CIGCGICAKVCPVNNIEM-EDGKPVWGHN-CTHCLACIHRCPKeAI 230
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 217-264 6.96e-03

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 36.98  E-value: 6.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2538878769 217 CIGCGLCLRNCSQGAIKIDNFVAVVDSSKCKDCpePTCLAKCPTGAIK 264
Cdd:cd03110    66 CIRCGNCERVCKFGAILEFFQKLIVDESLCEGC--GACVIICPRGAIY 111
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 142-189 7.35e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 36.08  E-value: 7.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 142 CIGFGNCVKACPFGAMSMGADGLPVVDK-----------DICTGCGK---CVSTCPQAILTL 189
Cdd:cd10554    87 CIGCKLCVLACPFGAIEMAPTTVPGVDWergpravavkcDLCAGREGgpaCVEACPTKALTL 148
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 142-265 7.45e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 36.08  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 142 CIGFGNCVKACPFGA-----MSMGADGL--PVVDKDI--CTGCGK-CVSTCP-QAIltlkgfnDPVEVLCSSHDKGPAak 210
Cdd:cd16373    16 CIRCGLCVEACPTGViqpagLEDGLEGGrtPYLDPREgpCDLCCDaCVEVCPtGAL-------RPLDLEEQKVKMGVA-- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 211 KLCQNACI------GCGLCLRNCSQGAIKI----DNFVAVVDSSKCKDCpePTCLAKCPTGAIKA 265
Cdd:cd16373    87 VIDKDRCLawqggtDCGVCVEACPTEAIAIvledDVLRPVVDEDKCVGC--GLCEYVCPVEPPKA 149
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 178-263 7.57e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 37.42  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538878769 178 CVSTCP-QAILTLkgfNDPVEVLcsshdkgpaakklcQNACIGCGLCLRNCSQGAIKIDNFVAVVDSSK--------CKD 248
Cdd:PRK12769   64 CARSCPnGAISHV---DDSIQVN--------------QQKCIGCKSCVVACPFGTMQIVLTPVAAGKVKatahkcdlCAG 126

                          90
                  ....*....|....*.
gi 2538878769 249 CPE-PTCLAKCPTGAI 263
Cdd:PRK12769  127 RENgPACVENCPADAL 142
Fer4_9 pfam13187
4Fe-4S dicluster domain;
171-232 8.72e-03

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 33.68  E-value: 8.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2538878769 171 ICTGCGKCVSTCPQAILTLKGFNDPVEVLCSShdkgpaakklcqNACIGCGLCLRNCSQGAI 232
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGQTIRGDIAG------------LACIGCGACVDACPRGAI 50
NarH_like cd16365
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ...
 148-219 9.74e-03

beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor.


Pssm-ID: 319887 [Multi-domain]  Cd Length: 201  Bit Score: 36.41  E-value: 9.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2538878769 148 CVKACPFGAM-SMGADGLPVVDKDICTGCGKCVSTCPQAILTLKGFNDPVE--VLCSSHDKGPAAKKlCQNACIG 219
Cdd:cd16365    81 CLAACPRGAIyKREEDGIVLIDQKRCRGYRKCVEQCPYKKIYFNGLSRVSEkcIACYPRIEGGDPTR-CMSACVG 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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