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Conserved domains on  [gi|2531923332|ref|WP_289836119|]
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MFS transporter [Collinsella ihumii]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 36-401 5.16e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd06173:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 383  Bit Score: 84.97  E-value: 5.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  36 IGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPK---AHTAVALGVAVAS-SALFQAAGGSVAAVLAMSAA 111
Cdd:cd06173    22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllILADLLRALLAAVlALLALLGSLSLWLLLVLAFL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 112 FGFATGVGY-AYLSAYPAYLSDdaEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPsqrvFAFTAVLSALALVPAGALL 190
Cdd:cd06173   102 LGIASAFFGpARQALLPELVPK--EQLVRANALNSLATQLARIIGPALGGLLVALLG----PGGAFAINALSFLLSALLL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 191 RRIGASARAGERERGDSQGPEgstLADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSA 270
Cdd:cd06173   176 LFIRRPPPAAPGESSSLLLRD---LREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 271 AGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLG 350
Cdd:cd06173   253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRG 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2531923332 351 RVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVA 401
Cdd:cd06173   333 RVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 36-401 5.16e-18

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 84.97  E-value: 5.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  36 IGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPK---AHTAVALGVAVAS-SALFQAAGGSVAAVLAMSAA 111
Cdd:cd06173    22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllILADLLRALLAAVlALLALLGSLSLWLLLVLAFL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 112 FGFATGVGY-AYLSAYPAYLSDdaEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPsqrvFAFTAVLSALALVPAGALL 190
Cdd:cd06173   102 LGIASAFFGpARQALLPELVPK--EQLVRANALNSLATQLARIIGPALGGLLVALLG----PGGAFAINALSFLLSALLL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 191 RRIGASARAGERERGDSQGPEgstLADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSA 270
Cdd:cd06173   176 LFIRRPPPAAPGESSSLLLRD---LREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 271 AGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLG 350
Cdd:cd06173   253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRG 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2531923332 351 RVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVA 401
Cdd:cd06173   333 RVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-367 3.07e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 82.33  E-value: 3.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  14 FALAAVRFMLYLGVqaSYFIGIIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSA 93
Cdd:COG2814    13 LALALGAFLSGLGI--GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  94 LFqAAGGSVAAVLAMSAAFGFATGVGYAYLSAYPAYLSDdAEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFA 173
Cdd:COG2814    91 LC-ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 174 FTAVLSALALVPAGALLRRigasaragerergdSQGPEGSTLADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYY 253
Cdd:COG2814   169 VNAVLALLALLLLLRLLPE--------------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 254 RDVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVT 333
Cdd:COG2814   235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2531923332 334 PLQHTLVQMHAPLHLLGRVNSVMNAGFSGAGAVP 367
Cdd:COG2814   315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
21-366 7.14e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 7.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  21 FMLYLGVQASYFIGIIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKaHTAVALGVAVASSALFQAAGG 100
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR-RVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 101 SVAAVLAMSAAFGFATGVGYAYLSAYPAYLSDDaEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSA 180
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 181 LALVPAGALLRRIGASARAGERERGDSqgpegstlADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYyRDVLQVD 260
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAEEARLS--------LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 261 ISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTL---MLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQH 337
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllaLLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                         330       340
                  ....*....|....*....|....*....
gi 2531923332 338 TLVQMHAPLHLLGRVNSVMNAGFSGAGAV 366
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGAL 342
PRK10489 PRK10489
enterobactin transporter EntS;
255-396 1.40e-07

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 53.06  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 255 DVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRrWVNVRTLMLLIAFEGAACVLYVGTS-HVGCAIAGQLLLGCAFGMVT 333
Cdd:PRK10489  252 EVWQMGAAQIGLLYAAVPLGAALGALTSGWLAH-SARPGLLMLLSTLGSFLAVGLFGLMpMWILAVLCLALFGYLSAISS 330

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2531923332 334 PLQHTLVQMHAPLHLLGRVNSVMNA--------GFSGAGAVPLFAAPVLAHL-FGVQGVLIGASCVVLLVPL 396
Cdd:PRK10489  331 LLQYTLLQTQTPDEMLGRINGLWTAqnvtgdaiGAALLGGLGAMMTPVASASaSGFGLLIIGVLLLLVLGEL 402
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 36-401 5.16e-18

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 84.97  E-value: 5.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  36 IGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPK---AHTAVALGVAVAS-SALFQAAGGSVAAVLAMSAA 111
Cdd:cd06173    22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllILADLLRALLAAVlALLALLGSLSLWLLLVLAFL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 112 FGFATGVGY-AYLSAYPAYLSDdaEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPsqrvFAFTAVLSALALVPAGALL 190
Cdd:cd06173   102 LGIASAFFGpARQALLPELVPK--EQLVRANALNSLATQLARIIGPALGGLLVALLG----PGGAFAINALSFLLSALLL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 191 RRIGASARAGERERGDSQGPEgstLADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSA 270
Cdd:cd06173   176 LFIRRPPPAAPGESSSLLLRD---LREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 271 AGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLG 350
Cdd:cd06173   253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRG 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2531923332 351 RVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVA 401
Cdd:cd06173   333 RVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-367 3.07e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 82.33  E-value: 3.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  14 FALAAVRFMLYLGVqaSYFIGIIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSA 93
Cdd:COG2814    13 LALALGAFLSGLGI--GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  94 LFqAAGGSVAAVLAMSAAFGFATGVGYAYLSAYPAYLSDdAEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFA 173
Cdd:COG2814    91 LC-ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 174 FTAVLSALALVPAGALLRRigasaragerergdSQGPEGSTLADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYY 253
Cdd:COG2814   169 VNAVLALLALLLLLRLLPE--------------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 254 RDVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVT 333
Cdd:COG2814   235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2531923332 334 PLQHTLVQMHAPLHLLGRVNSVMNAGFSGAGAVP 367
Cdd:COG2814   315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-402 1.93e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.07  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  42 QLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALFqAAGGSVAAVLAMSAAFGFATGvgyA 121
Cdd:cd17325    25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF-AFATSYWQLLLARFLQGLASA---A 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 122 YLSAYPAYLSD--DAEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSALALVPAGALLRRigasara 199
Cdd:cd17325   101 VWPAAMALIADiaPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 200 gERERGDSQGPEGSTLADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLGSVVGA 279
Cdd:cd17325   174 -PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 280 LAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRVNSVMNAG 359
Cdd:cd17325   253 PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2531923332 360 FSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVAR 402
Cdd:cd17325   333 FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
21-366 7.14e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 7.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  21 FMLYLGVQASYFIGIIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKaHTAVALGVAVASSALFQAAGG 100
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR-RVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 101 SVAAVLAMSAAFGFATGVGYAYLSAYPAYLSDDaEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSA 180
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 181 LALVPAGALLRRIGASARAGERERGDSqgpegstlADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYyRDVLQVD 260
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAEEARLS--------LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 261 ISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTL---MLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQH 337
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllaLLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                         330       340
                  ....*....|....*....|....*....
gi 2531923332 338 TLVQMHAPLHLLGRVNSVMNAGFSGAGAV 366
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGAL 342
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
84-340 7.45e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 60.30  E-value: 7.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  84 ALGVAVASSALFQAAGGSVAAVLAMSAAFGFATGVGYAYL----SAYPAYLSDDAEQRKRMNAIMSVVSNVAVVVGPAVG 159
Cdd:COG2211    88 AIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVnipySALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLP 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 160 GIIATFLPSQRVFAFTAVLSALALVPAGALLrrigaSARAGERERGDSQgPEGSTLADSTRTVFAAPSLALLFWVGVLAY 239
Cdd:COG2211   168 PPLVAAFGGDAALGYRLTALIFAVLGLLAFL-----LTFFGTKERPVPE-EEKVSLKESLKALLKNRPFLLLLLAYLLFF 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 240 AGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLY--VGTSHVGC 317
Cdd:COG2211   242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLffLGPGNLWL 321

                         250       260
                  ....*....|....*....|...
gi 2531923332 318 AIAGQLLLGCAFGMVTPLQHTLV 340
Cdd:COG2211   322 LLVLAALAGIGLGAILVLPWAML 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 42-393 5.40e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.44  E-value: 5.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  42 QLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALFqAAGGSVAAVLAMSAAFGFATGVgya 121
Cdd:cd06174    25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-AFAPSFWLLLLGRFLLGLGSGL--- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 122 YLSAYPAYLSDDAEQRKRmnAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSALALVPAGALLRRIGASARAGE 201
Cdd:cd06174   101 IDPAVLALIADLFPERER--GRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 202 RERGDSQGPEGSTLADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLGSVVGALA 281
Cdd:cd06174   179 SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 282 AMRVPRRWVNVRTLMLL-IAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRVNSVMNA-G 359
Cdd:cd06174   259 LGLLSDRLIGRKPLLLIgLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTfG 338

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2531923332 360 FSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLL 393
Cdd:cd06174   339 FLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLL 372
PRK10489 PRK10489
enterobactin transporter EntS;
255-396 1.40e-07

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 53.06  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 255 DVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRrWVNVRTLMLLIAFEGAACVLYVGTS-HVGCAIAGQLLLGCAFGMVT 333
Cdd:PRK10489  252 EVWQMGAAQIGLLYAAVPLGAALGALTSGWLAH-SARPGLLMLLSTLGSFLAVGLFGLMpMWILAVLCLALFGYLSAISS 330

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2531923332 334 PLQHTLVQMHAPLHLLGRVNSVMNA--------GFSGAGAVPLFAAPVLAHL-FGVQGVLIGASCVVLLVPL 396
Cdd:PRK10489  331 LLQYTLLQTQTPDEMLGRINGLWTAqnvtgdaiGAALLGGLGAMMTPVASASaSGFGLLIIGVLLLLVLGEL 402
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 39-398 1.92e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 52.61  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  39 LTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALFqAAGGSVAAVLAMSAAFGFATGV 118
Cdd:cd17329    26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL-GFAHSPWLFAIALVLTGFGGGL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 119 GYAYLSAYPAYLSDDaEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQrVFAFTAVLSALALVPAGALLRRIGASAR 198
Cdd:cd17329   105 FEPASEAMIADVTTP-ENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRL-LFLAAAVLFLLAALVLLFLLPETRPKRR 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 199 AGERERGdsqgpegstlADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLGSVVG 278
Cdd:cd17329   183 AAEKTEI----------LRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 279 ALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRVNSVMNA 358
Cdd:cd17329   253 QFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL 332

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2531923332 359 GFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIV 398
Cdd:cd17329   333 AWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALL 372
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 250-402 2.07e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 52.58  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 250 SLYYRDVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAF 329
Cdd:cd17473   221 PFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGF 300

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2531923332 330 GMVTPLQHTLVQMHAPLHLLGRVNSVMNAGFSGAGAV-PLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVAR 402
Cdd:cd17473   301 GLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
35-403 4.75e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 4.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  35 IIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALFqAAGGSVAAVLAMSAAFGF 114
Cdd:COG2271    32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF-GFATSFWQLLLLRFLLGL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 115 ATGVGYAYLSAYPAYLSDDAEqRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSAlalvpagallrrig 194
Cdd:COG2271   111 GEAGFFPAALKLIAEWFPPKE-RGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGL-------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 195 asaragerergdsqgpegstladstrtVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLG 274
Cdd:COG2271   176 ---------------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLA 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 275 SVVGALAAMRVPRRWVNVRTLMLLIAF--EGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRV 352
Cdd:COG2271   229 GIVGSLLGGWLSDRLGRRRKLVLAIGLllAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTA 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2531923332 353 NSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVARR 403
Cdd:COG2271   309 SGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
218-398 2.00e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.59  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 218 STRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDvLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLML 297
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 298 LIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRVNSVMNAGFSGAGAVPLFAAPVLAHL 377
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         170       180
                  ....*....|....*....|.
gi 2531923332 378 FGVQGVLIGASCVVLLVPLIV 398
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLL 181
MFS_1 pfam07690
Major Facilitator Superfamily;
231-403 2.59e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 231 LFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYV 310
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 311 GTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCV 390
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170
                  ....*....|...
gi 2531923332 391 VLLVPLIVMVARR 403
Cdd:pfam07690 161 SLLAAVLLLLPRP 173
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
10-403 3.69e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.72  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  10 PRGTFALAAVRFMLYLGVQASYFIgIIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAhTAVALGVAV 89
Cdd:COG2223     3 RWRVLLLATLAFFLAFGVWYLWSV-LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR-VLLIGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  90 ASSALFQAAGGSVAAVLAMSAAFGFATGVGYAYLSAYPAYLSDdAEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQ 169
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFP-PDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 170 RVFAFTAVLSALALVPAGALLRRIGASARAGERERGDSQgpegstladstRTVFAAPSLALLFWVGVLAYAGYGAFDPLE 249
Cdd:COG2223   160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ-----------LEALRDPRFWLLSLLYFGTFGSFIGFSSWL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 250 SLYYRDVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSH-VGCAIAGQLLLGCA 328
Cdd:COG2223   229 PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLA 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2531923332 329 FGMVTPLQHTLVQMHAPLHLLGRVNSVMNA-GFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVARR 403
Cdd:COG2223   309 LGGGNGAVFALVPDIFPTKNAGAVYGLVGAaGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
35-403 1.03e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  35 IIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALFqAAGGSVAAVLAMSAAFGF 114
Cdd:COG0738    30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF-ALAPSYPLLLLALFLLGL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 115 ATGVGYAYLSAYPAYLSDDaEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSALALVPAGALLRRIG 194
Cdd:COG0738   109 GLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLP 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 195 ASARAGERERGDsqgpegstlADSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLG 274
Cdd:COG0738   188 EIEEEEEEAAGS---------AASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGG 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 275 SVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRVNS 354
Cdd:COG0738   259 MTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSA 338

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2531923332 355 VMNAGFSGAGAVPLFAApVLAHLFGVQGVLIGASCVVLLVPLIVMVARR 403
Cdd:COG0738   339 VLIMGIVGGAIGPPLIG-FLADAFGLRAAFLVPLVCYLLILLLALALKR 386
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 31-392 1.04e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.16  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  31 YFIGIIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALfQAAGGSVAAVLAMSA 110
Cdd:cd17324    17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL-AALAPSFALLLLARA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 111 AFGFATGVGYAYLSAYPAYLSDdAEQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSALALVPAGALL 190
Cdd:cd17324    96 LAGLAHGGFWAIAAAYAADLVP-PEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 191 RRIGASARAGERERGdsqgpegstladSTRTVFAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSA 270
Cdd:cd17324   175 PSLPPKKPGSLGLLS------------SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 271 AGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHlLG 350
Cdd:cd17324   243 FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RG 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2531923332 351 RVNSVMN-AGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVL 392
Cdd:cd17324   322 LASSLYLaAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
254-403 5.49e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 5.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 254 RDVLQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVT 333
Cdd:COG2807    45 RADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGN 124

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2531923332 334 PLQHTLVQMHAPLHlLGRVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVL--IGASCVVLLVPLIVMVARR 403
Cdd:COG2807   125 VLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALavWALLALLALLLWLPLLRRR 195
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 223-399 6.45e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 6.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 223 FAAPSLALLFWVGVLAYAGYGAFDPLESLYYRDVLQVDISWMGWLSSAAGLGSVVGALAAMR-VPRRWVNVRTLMLLIAF 301
Cdd:cd17474   195 LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 302 EGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAPLHLLGRVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQ 381
Cdd:cd17474   275 YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS 354

                         170
                  ....*....|....*...
gi 2531923332 382 GVLIGASCVVLLVPLIVM 399
Cdd:cd17474   355 APFLVGAAIALAAAVLLA 372
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 21-402 9.47e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 9.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  21 FMLYLGVQasYFIGIIGTLTYQLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALFQAAGg 100
Cdd:cd17489     6 FFFFLSFY--LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 101 SVAAVLAMSAAFGFATGvgyAYLSAYPAYLSDDAEQRKRMNAI--MSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVL 178
Cdd:cd17489    83 SVALLLVLRLIHGIGWG---AFTTAAATLVADIIPPSRRGEGIgyYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 179 SALALVpaGALLRRIGASARAGERErgdsqgPEGSTLADSTRTVFAAPSLALLfwvgvLAYAGYGAFDPLESLYYRDVLQ 258
Cdd:cd17489   160 ALLALL--LVFLVKDPPPVAAEEAE------AGTRAFRRLVEKKVLPPALILF-----LASIAYGAISTFLPLYAAERGI 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 259 VDIswmGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHT 338
Cdd:cd17489   227 SNA---GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA 303

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2531923332 339 LVQMHAPLHLLGRVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVAR 402
Cdd:cd17489   304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 84-335 1.46e-04

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 43.84  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  84 ALGVAVASSALFQAAGGSVAAVLAMSAAFGFATGVGYAYLS----AYPAYLSDDAEQRKRMNAIMSVVSNVAVVVGPAVG 159
Cdd:pfam13347  75 AIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEipywSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 160 GIIATFL---PSQRVFAFTAVLSALALVPAGALLRRIGASARAGERERGDSQGPEGSTLADSTRTVFAAPSLALLFWVGV 236
Cdd:pfam13347 155 FPLVLILggtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 237 LAYAGYGAFDPLESLYYRDVLQvDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLML--LIAFEGAACVLYVGTSH 314
Cdd:pfam13347 235 LAALAMGVLNGLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILgaLITIAGFALALLLGPNN 313

                         250       260
                  ....*....|....*....|.
gi 2531923332 315 VGCAIAGQLLLGCAFGMVTPL 335
Cdd:pfam13347 314 TLLFLVLYIIIGFGYGSSFFL 334
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
42-407 5.19e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 38.70  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  42 QLHAGTGDIAMAVGLFNLFIIAGNTAGGSLLDTHGPKAHTAVALGVAVASSALFqAAGGSVAAVLAMSAAFGFATGVGYA 121
Cdd:COG2807    47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR-SLAPSVALLLAGTALIGAGIAVGNV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 122 ylsAYPAYLSDDAEQRK-RMNAIMSVVSNVAVVVGPAVGGIIATFLPSQRVFAFTAVLSALALVPAGALLRRIGASARAg 200
Cdd:COG2807   126 ---LLPGLIKRWFPDRVgLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 201 erergdsqgpegSTLADSTRTVFAAP---SLALLFWVGVLAYAGYGAFDPLeslYYRDvLQVDISWMGWLSSAAGLGSVV 277
Cdd:COG2807   202 ------------APAAASLRSLWRSPlawLLTLFFGLQSLLYYAVVAWLPP---ILRD-AGLSAATAGLLLSLFQLAGIP 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 278 GALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQMHAP-LHLLGRVNSVM 356
Cdd:COG2807   266 GSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMA 345

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2531923332 357 N-AGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMVARRSEIS 407
Cdd:COG2807   346 QsVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 135-395 6.46e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 38.75  E-value: 6.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  135 EQRKRMNAIMSVVSNVAVVVGPAVGGIIATFLPS-------QRVFAFTAVLSALALVPAgALLRRIGASARAGERERGDS 207
Cdd:PRK08633   135 ENLSRANGLLEAFTIVAILAGTALFSFLFESVNGntpseilGRIAPAGLVLLAVAVLGL-IFAYRLPKVPAAAPEVFDKK 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  208 QGPEGSTLADSTRTVFAAPSLAL------LFW-VGVLAYAgygAFDPleslYYRDVLQVDISW-MGWLSSAAGLGSVVGA 279
Cdd:PRK08633   214 KYLFPKLLWRNLKLLRSDRVLWLaiiglsYFWfISQLAQA---NFPA----YAKEVLGLDNTFqVQYLLAASAIGIGIGS 286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332  280 LAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGM-VTPLQhTLVQMHAPLHLLGRV------ 352
Cdd:PRK08633   287 LLAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLfIVPLN-ALIQFRAPEKELGKVlaannf 365

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2531923332  353 -NSVMNAGFSGAGAVPLFAAPVLAHLFGVQGV--LIGASCVVLLVP 395
Cdd:PRK08633   366 lQNVGMLLFLALTTLFSGLGLSPAGLFYLIALvtLIGTLYTLLLLP 411
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 257-400 7.52e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 38.34  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 257 LQVDISWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQ 336
Cdd:cd17365    29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNA 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2531923332 337 HTLVQMHAPLHLLGRVNSVMNAGFSGAGAVPLFAAPVLAHLFGVQGVLIGASCVVLLVPLIVMV 400
Cdd:cd17365   109 ITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRG 172
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 262-405 8.27e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 37.92  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923332 262 SWMGWLSSAAGLGSVVGALAAMRVPRRWVNVRTLMLLIAFEGAACVLYVGTSHVGCAIAGQLLLGCAFGMVTPLQHTLVQ 341
Cdd:cd17477    31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLN 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2531923332 342 MHAPLHLLGRVNSVMNAGFSGAGAVplfaAPVLAHLFGVQGVL--IGASCVVLLVPLIVMVARRSE 405
Cdd:cd17477   111 ALATNENRGRVLGLYSTVLGLGFAL----GPLLLALVGTAGALpfLIAAVLLLLALVPLLLTRRAA 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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