|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
14-385 |
5.73e-62 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 204.09 E-value: 5.73e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 14 WGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAV 93
Cdd:TIGR00900 5 FAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLPFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 94 SATGALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALD 173
Cdd:TIGR00900 85 ALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 174 VLGALLATVAVMVARLDvggaqaageaeAAGPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSP-ISAL 252
Cdd:TIGR00900 165 AVGFAISALLIVSVRIP-----------ELAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVFAPaIVAL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 253 FPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPNgYVTFLAMSFLMG 332
Cdd:TIGR00900 234 FPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPPN-FPLFLVLWFAIG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2531923287 333 VSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVG 385
Cdd:TIGR00900 313 VGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-390 |
1.64e-45 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 161.63 E-value: 1.64e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 14 WGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAV 93
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 94 SATGALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALD 173
Cdd:cd06173 85 ALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 174 VLGALLATVAVMVARLDVggaqaageaeaagPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPISALF 253
Cdd:cd06173 165 ALSFLLSALLLLFIRRPP-------------PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 254 PLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPngYVTFLAMSFLMGV 333
Cdd:cd06173 232 PLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS--LWLLLAALFLLGL 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2531923287 334 SSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVGATLWF 390
Cdd:cd06173 310 AGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-367 |
9.04e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.93 E-value: 9.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 10 LACVWGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSAL 89
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 90 VAAvsatgALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAM 169
Cdd:COG2814 92 CAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 170 IALDVLGALLATVAVMVArldvggaqaageaeaagpvgISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPI 249
Cdd:COG2814 167 FLVNAVLALLALLLLLRL--------------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 250 SALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGpnGYVTFLAMSF 329
Cdd:COG2814 227 FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALF 304
|
330 340 350
....*....|....*....|....*....|....*...
gi 2531923287 330 LMGVSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMS 367
Cdd:COG2814 305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
11-388 |
3.99e-12 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 67.85 E-value: 3.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 11 ACVWGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALV 90
Cdd:pfam05977 13 RVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 91 AAVSATGALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQA----VQSGGYILGTAVAAVIYPLW-- 164
Cdd:pfam05977 93 TLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVgyniARSVGPALGGVLLAAFGPAFtf 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 165 GLTAMIALDVLGALLATVAVMVARldvggaqaageaeAAGPVGISSRVRallqeaaAGYRVLRAYRSLFALLWCGFVFTL 244
Cdd:pfam05977 173 ALNALSYFAVIAALWRWKRAAPAS-------------PLPRERIFGAVR-------AGLRFTAMSRELRSVLVRAFAFGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 245 VFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLgPNGYVTF 324
Cdd:pfam05977 233 SASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALA-PNLWLAI 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2531923287 325 LAMSFLMGVSSPFYSGPQIAlMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVGATL 388
Cdd:pfam05977 312 PVLLLGGAAWITALTTLNVA-VQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTG 374
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
44-358 |
3.37e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 55.70 E-value: 3.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 44 ILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAVSATGALpvWVVIVALFFRAIGSAFHAPAFQ 123
Cdd:PRK08633 48 LTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWF--WLAFAVTFLLGAQSAIYSPAKY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 124 TLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWglTAMIALDVLG--ALLATVAVMVARLDVGGAQAAGEAE 201
Cdd:PRK08633 126 GIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESV--NGNTPSEILGriAPAGLVLLAVAVLGLIFAYRLPKVP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 202 AAGPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFS-VGMI 280
Cdd:PRK08633 204 AAAPEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASaIGIG 283
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2531923287 281 AGSALLASTGGFKnRALTVVAATALYGAATLVAgLLGPNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRV 358
Cdd:PRK08633 284 IGSLLAGRLSGRH-IELGLVPLGALGLALSLFL-LPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKV 359
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
14-385 |
5.73e-62 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 204.09 E-value: 5.73e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 14 WGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAV 93
Cdd:TIGR00900 5 FAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLPFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 94 SATGALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALD 173
Cdd:TIGR00900 85 ALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 174 VLGALLATVAVMVARLDvggaqaageaeAAGPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSP-ISAL 252
Cdd:TIGR00900 165 AVGFAISALLIVSVRIP-----------ELAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVFAPaIVAL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 253 FPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPNgYVTFLAMSFLMG 332
Cdd:TIGR00900 234 FPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPPN-FPLFLVLWFAIG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2531923287 333 VSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVG 385
Cdd:TIGR00900 313 VGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-390 |
1.64e-45 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 161.63 E-value: 1.64e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 14 WGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAV 93
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 94 SATGALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALD 173
Cdd:cd06173 85 ALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 174 VLGALLATVAVMVARLDVggaqaageaeaagPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPISALF 253
Cdd:cd06173 165 ALSFLLSALLLLFIRRPP-------------PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 254 PLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPngYVTFLAMSFLMGV 333
Cdd:cd06173 232 PLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS--LWLLLAALFLLGL 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2531923287 334 SSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVGATLWF 390
Cdd:cd06173 310 AGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-367 |
9.04e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.93 E-value: 9.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 10 LACVWGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSAL 89
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 90 VAAvsatgALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAM 169
Cdd:COG2814 92 CAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 170 IALDVLGALLATVAVMVArldvggaqaageaeaagpvgISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPI 249
Cdd:COG2814 167 FLVNAVLALLALLLLLRL--------------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 250 SALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGpnGYVTFLAMSF 329
Cdd:COG2814 227 FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALF 304
|
330 340 350
....*....|....*....|....*....|....*...
gi 2531923287 330 LMGVSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMS 367
Cdd:COG2814 305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-385 |
9.08e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.14 E-value: 9.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 41 SASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIgadlfIAAVSALVAAVSATGALPVWVVIVALFFRAIGSAFHAP 120
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL-----LGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 121 AFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALDVLGALLATVAVMVARLDvggaqaagea 200
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE---------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 201 eaagPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMI 280
Cdd:cd17325 174 ----PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 281 AGSALLASTGGFKNRALTVVAATALYGAATLVAGLlgPNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRVFG 360
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL--ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327
|
330 340
....*....|....*....|....*
gi 2531923287 361 LYGAIMSWALPIGLAVSSLFADGVG 385
Cdd:cd17325 328 LFNTAFSLGMVLGPLLGGFLYDAFG 352
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
11-388 |
3.99e-12 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 67.85 E-value: 3.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 11 ACVWGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALV 90
Cdd:pfam05977 13 RVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 91 AAVSATGALPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQA----VQSGGYILGTAVAAVIYPLW-- 164
Cdd:pfam05977 93 TLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVgyniARSVGPALGGVLLAAFGPAFtf 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 165 GLTAMIALDVLGALLATVAVMVARldvggaqaageaeAAGPVGISSRVRallqeaaAGYRVLRAYRSLFALLWCGFVFTL 244
Cdd:pfam05977 173 ALNALSYFAVIAALWRWKRAAPAS-------------PLPRERIFGAVR-------AGLRFTAMSRELRSVLVRAFAFGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 245 VFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLgPNGYVTF 324
Cdd:pfam05977 233 SASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALA-PNLWLAI 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2531923287 325 LAMSFLMGVSSPFYSGPQIAlMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVGATL 388
Cdd:pfam05977 312 PVLLLGGAAWITALTTLNVA-VQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTG 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-373 |
7.55e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.04 E-value: 7.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 13 VWGGELISVLTSSILQMGFIWHITLSTN-SASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVA 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 92 AVSatgalPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIA 171
Cdd:pfam07690 81 FAS-----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 172 LDVLGALLATVAVMVARLDvggaqaageaeaaGPVGISSRVRALLQEAAAGYRVLRAYRsLFALLWCGFVFTLVFSPISA 251
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPP-------------PESKRPKPAEEARLSLIVAWKALLRDP-VLWLLLALLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 252 LFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPNGYVTFLAMSFLM 331
Cdd:pfam07690 222 YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2531923287 332 GVSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIG 373
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-386 |
1.14e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 56.67 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 13 VWGGELISVLTSSILQMGFIWHITLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAA 92
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 93 VSatgalPVWVVIVALFFRAIGSAFHAPAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVI--YPLWGLTAMI 170
Cdd:cd06174 81 AP-----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 171 ALDVLGALLATVAVMVARLDVGGAQAAGEAeaagpvgissrvRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPIS 250
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNE------------EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 251 ALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPNGYVTFLAMSFL 330
Cdd:cd06174 224 TLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2531923287 331 mGVSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVGA 386
Cdd:cd06174 304 -GFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
44-358 |
3.37e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 55.70 E-value: 3.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 44 ILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAVSATGALpvWVVIVALFFRAIGSAFHAPAFQ 123
Cdd:PRK08633 48 LTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWF--WLAFAVTFLLGAQSAIYSPAKY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 124 TLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWglTAMIALDVLG--ALLATVAVMVARLDVGGAQAAGEAE 201
Cdd:PRK08633 126 GIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESV--NGNTPSEILGriAPAGLVLLAVAVLGLIFAYRLPKVP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 202 AAGPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFS-VGMI 280
Cdd:PRK08633 204 AAAPEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASaIGIG 283
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2531923287 281 AGSALLASTGGFKnRALTVVAATALYGAATLVAgLLGPNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRV 358
Cdd:PRK08633 284 IGSLLAGRLSGRH-IELGLVPLGALGLALSLFL-LPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKV 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
62-381 |
8.00e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 8.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 62 FAGVIVDRMPIKR------VLIGADLFIAAVSALVAAVSATGALPVWVVIVALFFRAIGSAFHAPAFQTLTP-LVAPPEH 134
Cdd:COG2211 65 LIGALSDRTRTRWgrrrpwILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeLTPDYEE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 135 LTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALDVLGALLATVAVMVArldvgGAQAAGEAEAAGPVGISSRVRA 214
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAF-----LLTFFGTKERPVPEEEKVSLKE 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 215 LLqeaaagyRVLRAYRSLFALLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKN 294
Cdd:COG2211 220 SL-------KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 295 RALTVVAATALYGAATLVAGLLGPNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYL---GRVFGLYGAIMSWALP 371
Cdd:COG2211 293 KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTFAIK 372
|
330
....*....|
gi 2531923287 372 IGLAVSSLFA 381
Cdd:COG2211 373 LGQALAGALA 382
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
36-384 |
1.36e-06 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 50.73 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 36 TLSTNSASILSLASLAGFLPLAAFGTFAGVIVDRMP---IKRVLIGADLFIAAVSALVAAVSAtgalpVWVVIVALFFRA 112
Cdd:PRK06814 45 ALGAYNNALVTLAGAVFILPFFIFSALAGQLADKYDkakLAKILKFAEIGIAALAIYGFHLNS-----VPLLFAALFLMG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 113 IGSAFHAP-AFQTLtplvapPEHLTR--LAGVSQAVQSGGYI---LGTaVAAVIYPLWGLTAmialdVLGALLATVAVM- 185
Cdd:PRK06814 120 IHSALFGPiKYSIL------PDHLNKdeLLGANALVEAGTFIailLGT-IIGGLATISGNFV-----ILVALLMGIAVLg 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 186 -VARLDVGGAQAAGEAEAAGPVGISSRVRaLLQEAAAGYRVlraYRSLFALLWcgfvFTLVFSPISALFPLMTIDHFGGT 264
Cdd:PRK06814 188 wLASLFIPKTGNAAPDLKIDRNIIRSTIT-LLKYAKADKRI---WLAILGISW----FWLVGAVVLSQLPLLAKETLGGD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 265 TTDAATAEIVFSVGMIAGSALLAS-TGGFKNRALTVVAATAL--------YGAATLVAGLLGPNGYVTFLAMS------- 328
Cdd:PRK06814 260 ENVATLFLAVFSVGVAVGSFLASKlSEGRITLLYVPIGALLMglfgldlaFASSSVPAEPAQLKSILVFLSKRhgwrili 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 329 --FLMGVSSPFYSGPQIALMQEKVPPEYLGRVFGLyGAIMSWALPIG--LAVSSLFADGV 384
Cdd:PRK06814 340 dlFGLAAAGGLYIVPLFAALQAWANPAHRARVIAA-NNVLNAAFMVAgtIILALLQALGF 398
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
224-376 |
4.99e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 48.39 E-value: 4.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 224 RVLRAYRSLFALLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRA-LTVVAA 302
Cdd:cd06179 256 RLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIkWQLVAG 335
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2531923287 303 TALYGAATLVAGLLGPNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAV 376
Cdd:cd06179 336 FVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAI 409
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-365 |
7.47e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.95 E-value: 7.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 41 SASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAvsatgALPVWVVIVALFFRAIGSAFHAP 120
Cdd:COG2223 38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL-----AVSYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 121 AFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIAldVLGALLATVAVMVARLdvggaqaagea 200
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL--ILGILLLVVAVLAWLF----------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 201 EAAGPVGISSRVRALLQEAAAGYRVLRAYRslfaLLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMI 280
Cdd:COG2223 180 LRDPPAGAAAAAKASLRDQLEALRDPRFWL----LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 281 AGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPNGYVtFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRVFG 360
Cdd:COG2223 256 LGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL-FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYG 334
|
....*
gi 2531923287 361 LYGAI 365
Cdd:COG2223 335 LVGAA 339
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
41-408 |
2.83e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 41 SASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIgadlfIAAVSALVAAVSATGALPVWVVIVALFFRAIGSAFHAP 120
Cdd:COG2271 43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLA-----IGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 121 AFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALDVLGALLATVAVMVArldvggaqaagea 200
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWL------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 201 eaagpvgissrvrallqeaaagyrvlrayrslfaLLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMI 280
Cdd:COG2271 185 ----------------------------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 281 AGSALLAS-TGGFKNRALTVVAATALYGAATLVAGLLGPNGYVTFLAMsFLMGVSSPFYSGPQIALMQEKVPPEYLGRVF 359
Cdd:COG2271 231 VGSLLGGWlSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALL-FLAGFGLGGAFGLLWALAAELFPKKARGTAS 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2531923287 360 GLYGAIMSWALPIGLAVSSLFADGVGATLWFAGAGAAMLLLALATWAIP 408
Cdd:COG2271 310 GLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
230-383 |
4.36e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.07 E-value: 4.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 230 RSLFALLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAeiVFSVGMIAGSALLASTGGF------KNRALTVVAAT 303
Cdd:PRK08633 9 IGFLPLLLTQFLNAFNDLGHKILIQNTLIKAYDGSEQVILTA--IVNALFLLPFLLLSSPAGFladkfsKNRVIRIVKLF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 304 ALYGAATLVAGLLGPNGYVTFlAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADG 383
Cdd:PRK08633 87 EVGLTLLIVLAYYLGWFWLAF-AVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFES 165
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-388 |
5.79e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 5.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 44 ILSLASLAGFLplaaFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAVSAtgalpVWVVIVALFFRAIGSAFHAPAFQ 123
Cdd:cd17329 40 VLALSAVAGIV----ASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS-----PWLFAIALVLTGFGGGLFEPASE 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 124 TLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALdvLGALLATVAVMVARLdvggaqaageaeaa 203
Cdd:cd17329 111 AMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAA--AVLFLLAALVLLFLL-------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 204 gPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPISALFPLMTIDHFGGTTTDAATAEIVFSVGMIAGS 283
Cdd:cd17329 175 -PETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 284 ALLASTGGFKNRALTVVAATALYGAATLVAGLLgpNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRVFGLYG 363
Cdd:cd17329 254 FPVARLVERFRLRKILMIGILLFAIGFAVLAFA--NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYA 331
|
330 340
....*....|....*....|....*
gi 2531923287 364 AIMSWALPIGLAVSSLFADGVGATL 388
Cdd:cd17329 332 LAWGLGRAIGPLVGGLLLDLLGPGL 356
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
227-385 |
8.07e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 227 RAYRSLFALLWCGFVFTLVFSPISALFPLMtIDHFGGTTTDAATAEIVFSVGMIAGSALLASTGGFKNRALTVVAATALY 306
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531923287 307 GAATLVAGLLgpNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGRVFGLYGAIMSWALPIGLAVSSLFADGVG 385
Cdd:COG2814 86 ALGSLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
41-361 |
3.03e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 41 SASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIaavSALVAAVSATGALPVWVVIVALFFRAIGSAFHAP 120
Cdd:cd17355 36 SRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLL---AAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 121 AFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALDVLGALLATVAVMVARldvggaqaagea 200
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLR------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 201 eaAGPVGISSRVRALLQEAAAGYRVLRAYRS-LFALLWCGFVFTL--VFSPISALFPLMTidHFGGTTTDAATAEIVFSV 277
Cdd:cd17355 181 --RRPADLALRAYDDASPASPGSTLKEALRSaSFWLLALAFFLCGfaVVGLIVHLVPYLA--DRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 278 GMIAGSALLASTGGFKNRALTVVAATALyGAATLVAGLLGPNGYVTFLAMSFLMGVSSPFYSGPQIALMQEKVPPEYLGR 357
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRRLLAASYAL-RALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGT 335
|
....
gi 2531923287 358 VFGL 361
Cdd:cd17355 336 LFGL 339
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
42-390 |
4.24e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 42 ASILSLASLAGFLPLAAFGT--FAGVIVDRMPIKRVLIGADLFIAAVSALVAAVsatgALPVWVVIVALFFRAIGSAFHA 119
Cdd:cd17370 31 ASAAAVGLIEGLAEALGSLLrlFSGYLSDRTGKRKPLVILGYGLSALAKPLLAL----AGSWQLVLLLRILERLGKGIRT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 120 PAFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLT--AMIALDVLGALLATVAVMVARLDVggaqaa 197
Cdd:cd17370 107 PPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEY------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 198 geaeaagPVGISSRVRALLQEAAAGYRVLRAYRSLFALLWCGFVFtlvfspisalFPLMTIdHFGGTTTDAATAEIVFSV 277
Cdd:cd17370 181 -------PRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFS----------FAFLIL-RAQELGLSAALIPLLYAL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 278 GMIAgSALLASTGGF---KNRALTVVAATALYGAATLVAGLLGPNGYVTFLAMsFLMGVSSPFYSGPQIALMQEKVPPEY 354
Cdd:cd17370 243 FNLV-YALAAYPAGRlsdRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF-ILWGLYMGAQESIERAAVADLVPAEL 320
|
330 340 350
....*....|....*....|....*....|....*.
gi 2531923287 355 LGRVFGLYGAIMSWALPIGLAVSSLFADGVGATLWF 390
Cdd:cd17370 321 RGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF 356
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
41-390 |
6.23e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 6.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 41 SASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIgadLFIAAVSALVAAVSATGALPVWVVIVALFfrAIGSAFHAP 120
Cdd:cd17477 29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFA---AGAAITAVSVLLLALTDSPWVWFLLRFVM--GIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 121 AFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIAldVLGALLATVAVMVARLDvggaqaagea 200
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIA--AVLLLLALVPLLLTRRA---------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 201 eaagpvgissrvrALLQEAAAGYRVLRAYRSLFALLWCGFVFTLVFSPISALFPLMTIDHfGGTTTDAATAEIVFSVGMI 280
Cdd:cd17477 172 -------------APEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 281 AGSALLASTGGFKNRALTVVAATALYGAATLVAGLLGPNGYVTFLAMSFLMGVSSPFYSgPQIALMQEKVPPEYLGRVFG 360
Cdd:cd17477 238 LLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT-LALALAGDRLPGDELVAANA 316
|
330 340 350
....*....|....*....|....*....|
gi 2531923287 361 LYGAIMSWALPIGLAVSSLFADGVGATLWF 390
Cdd:cd17477 317 ALLLLYGLGSVIGPLLAGALMDAFGPHGLF 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-188 |
7.51e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531923287 41 SASILSLASLAGFLPLAAFGTFAGVIVDRMPIKRVLIGADLFIAAVSALVAAvsatgALPVWVVIVALFFRAIGSAFHAP 120
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALLGLGLGLVFP 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2531923287 121 AFQTLTPLVAPPEHLTRLAGVSQAVQSGGYILGTAVAAVIYPLWGLTAMIALDVLGALLATVAVMVAR 188
Cdd:cd17325 308 ATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| |
