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Conserved domains on  [gi|2508023212|ref|WP_283143436|]
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methyltransferase domain-containing protein [Streptomyces sp. BPTC-684]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
methyltr_grsp super family cl30236
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 18-302 3.01e-76

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


The actual alignment was detected with superfamily member TIGR04188:

Pssm-ID: 275041  Cd Length: 363  Bit Score: 238.03  E-value: 3.01e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  18 EIVAGGALADPAWRAAFEEVPRDLFVPYYFVGRSGG--YERLWGQDPDPARrarWLEGVYTDMPLATRVrDGELLSSSSQ 95
Cdd:TIGR04188   4 RLAAAGVLTDPAWREAVEAVPRHLFLPGFFTQLPDGrgWRPVTADRPDPDE---WLALVYSDETLVTQL-DGDLAADAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  96 PSL-------------MARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPA 162
Cdd:TIGR04188  80 GPVtgrptssstqpslVARMLEALDVEDGHRVLEIGTGTGYSAALLCHRLGDDNVTSVEVDPGLAARAASALAAAGYAPT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 163 VVTGDGARGCPSRAPFDRIIATCTLPSVPAGWLAQCTPGALIEAPL-----ATGLILLKVRDAGHAQGRFLHTPAYFVPL 237
Cdd:TIGR04188 160 VVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLsgwlyGGGLVRLTVDDDGTAEGRFLPGYASFMPA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 238 RGVAPAP------------GTPYTGGLPRPSLENELFRFLLALTAD-----TLDPY------------------------ 276
Cdd:TIGR04188 240 RPQAPPPaagdlsaaaadaGDRRTTRLPPALLEDWTGAFLAQLAAPdaqllTLTPDtgspqvlldvadgswaeltpdggg 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2508023212 277 ----------------EAYELWRREGRPVRERFGVTVTEEGQ 302
Cdd:TIGR04188 320 wtvrqggprrlwdaveEALDAWQAAGRPDRDAFGLTVTPNGH 361
 
Name Accession Description Interval E-value
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 18-302 3.01e-76

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 238.03  E-value: 3.01e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  18 EIVAGGALADPAWRAAFEEVPRDLFVPYYFVGRSGG--YERLWGQDPDPARrarWLEGVYTDMPLATRVrDGELLSSSSQ 95
Cdd:TIGR04188   4 RLAAAGVLTDPAWREAVEAVPRHLFLPGFFTQLPDGrgWRPVTADRPDPDE---WLALVYSDETLVTQL-DGDLAADAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  96 PSL-------------MARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPA 162
Cdd:TIGR04188  80 GPVtgrptssstqpslVARMLEALDVEDGHRVLEIGTGTGYSAALLCHRLGDDNVTSVEVDPGLAARAASALAAAGYAPT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 163 VVTGDGARGCPSRAPFDRIIATCTLPSVPAGWLAQCTPGALIEAPL-----ATGLILLKVRDAGHAQGRFLHTPAYFVPL 237
Cdd:TIGR04188 160 VVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLsgwlyGGGLVRLTVDDDGTAEGRFLPGYASFMPA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 238 RGVAPAP------------GTPYTGGLPRPSLENELFRFLLALTAD-----TLDPY------------------------ 276
Cdd:TIGR04188 240 RPQAPPPaagdlsaaaadaGDRRTTRLPPALLEDWTGAFLAQLAAPdaqllTLTPDtgspqvlldvadgswaeltpdggg 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2508023212 277 ----------------EAYELWRREGRPVRERFGVTVTEEGQ 302
Cdd:TIGR04188 320 wtvrqggprrlwdaveEALDAWQAAGRPDRDAFGLTVTPNGH 361
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 27-239 4.32e-49

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 162.57  E-value: 4.32e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  27 DPAWRAAFEEVPRDLFVPyyfvgrsggyerlwgqdpdPARRARwlegVYTDMPL---------ATRVrdgellssssqps 97
Cdd:COG2518    11 DPRVLDAMRAVPRELFVP-------------------EALREL----AYADRALpighgqtisQPYI------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  98 lMARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHLTAAGFR-PAVVTGDGARGCPSRA 176
Cdd:COG2518    55 -VARMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGR--VYSVERDPELAERARERLAALGYDnVTVRVGDGALGWPEHA 131

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2508023212 177 PFDRIIATCTLPSVPAGWLAQCTPGALIEAPLATG----LILLkVRDAGHAQGRFLhTPAYFVPLRG 239
Cdd:COG2518   132 PFDRIIVTAAAPEVPEALLEQLAPGGRLVAPVGEGgvqrLVLI-TRTGDGFERESL-FEVRFVPLRG 196
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
27-241 2.87e-30

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 114.15  E-value: 2.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  27 DPAWRAAFEEVPRDLFVPYYFvgrsggYERLWGQDPDPARRARWLEGVYTdmplatrvrdgellssssqpslMARMLEVL 106
Cdd:PRK00312   23 DERVLEAIEATPRELFVPEAF------KHKAYENRALPIGCGQTISQPYM----------------------VARMTELL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 107 DVRDGHAVLEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHLTAAGFRPAVVT-GDGARGCPSRAPFDRIIATC 185
Cdd:PRK00312   75 ELKPGDRVLEIGTGSGYQAAVLAHLVRR--VFSVERIKTLQWEAKRRLKQLGLHNVSVRhGDGWKGWPAYAPFDRILVTA 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2508023212 186 TLPSVPAGWLAQCTPGALIEAPLATGL--ILLKVRDAGhaqGRFL---HTPAYFVPL-RGVA 241
Cdd:PRK00312  153 AAPEIPRALLEQLKEGGILVAPVGGEEqqLLTRVRKRG---GRFErevLEEVRFVPLvKGEL 211
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
23-237 4.27e-24

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 97.44  E-value: 4.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  23 GALADPAWRAAFEEVPRDLFVPyyfvgrsggyerlwgqdpdparrARWLEGVYTDMPLATrvrdgELLSSSSQPSLMARM 102
Cdd:pfam01135  14 GVIKSDKVAEAMLAVDREEFVP-----------------------ESFKSYAYEDIPLSI-----GYGQTISAPHMHAMM 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 103 LEVLDVRDGHAVLEIGAGTGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGF-RPAVVTGDGARGCPSRAPFDR 180
Cdd:pfam01135  66 LELLELKPGMRVLEIGSGSGYLTACFARMVGeVGRVVSIEHIPELVEIARRNLEKLGLeNVIVVVGDGRQGWPEFAPYDA 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2508023212 181 IIATCTLPSVPAGWLAQCTPGALIEAPLATG----LILLKVRDAGHAQGRFLhTPAYFVPL 237
Cdd:pfam01135 146 IHVGAAAPEIPEALIDQLKEGGRLVIPVGPNgnqvLQQFDKRNDGSVVIKDL-EGVRFVPL 205
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 114-196 9.34e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.96  E-value: 9.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 114 VLEIGAGTGYNAALLShRLGDGLVTTVDLDPEITESARTHLTAAGFRPA-VVTGDGARG-CPSRAPFDRIIATCTLPSVP 191
Cdd:cd02440     2 VLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVeVLKGDAEELpPEADESFDVIISDPPLHHLV 80


                  ....*
gi 2508023212 192 AGWLA 196
Cdd:cd02440    81 EDLAR 85
 
Name Accession Description Interval E-value
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 18-302 3.01e-76

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 238.03  E-value: 3.01e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  18 EIVAGGALADPAWRAAFEEVPRDLFVPYYFVGRSGG--YERLWGQDPDPARrarWLEGVYTDMPLATRVrDGELLSSSSQ 95
Cdd:TIGR04188   4 RLAAAGVLTDPAWREAVEAVPRHLFLPGFFTQLPDGrgWRPVTADRPDPDE---WLALVYSDETLVTQL-DGDLAADAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  96 PSL-------------MARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPA 162
Cdd:TIGR04188  80 GPVtgrptssstqpslVARMLEALDVEDGHRVLEIGTGTGYSAALLCHRLGDDNVTSVEVDPGLAARAASALAAAGYAPT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 163 VVTGDGARGCPSRAPFDRIIATCTLPSVPAGWLAQCTPGALIEAPL-----ATGLILLKVRDAGHAQGRFLHTPAYFVPL 237
Cdd:TIGR04188 160 VVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLsgwlyGGGLVRLTVDDDGTAEGRFLPGYASFMPA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 238 RGVAPAP------------GTPYTGGLPRPSLENELFRFLLALTAD-----TLDPY------------------------ 276
Cdd:TIGR04188 240 RPQAPPPaagdlsaaaadaGDRRTTRLPPALLEDWTGAFLAQLAAPdaqllTLTPDtgspqvlldvadgswaeltpdggg 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2508023212 277 ----------------EAYELWRREGRPVRERFGVTVTEEGQ 302
Cdd:TIGR04188 320 wtvrqggprrlwdaveEALDAWQAAGRPDRDAFGLTVTPNGH 361
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 27-239 4.32e-49

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 162.57  E-value: 4.32e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  27 DPAWRAAFEEVPRDLFVPyyfvgrsggyerlwgqdpdPARRARwlegVYTDMPL---------ATRVrdgellssssqps 97
Cdd:COG2518    11 DPRVLDAMRAVPRELFVP-------------------EALREL----AYADRALpighgqtisQPYI------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  98 lMARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHLTAAGFR-PAVVTGDGARGCPSRA 176
Cdd:COG2518    55 -VARMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGR--VYSVERDPELAERARERLAALGYDnVTVRVGDGALGWPEHA 131

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2508023212 177 PFDRIIATCTLPSVPAGWLAQCTPGALIEAPLATG----LILLkVRDAGHAQGRFLhTPAYFVPLRG 239
Cdd:COG2518   132 PFDRIIVTAAAPEVPEALLEQLAPGGRLVAPVGEGgvqrLVLI-TRTGDGFERESL-FEVRFVPLRG 196
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 18-208 2.44e-32

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 124.02  E-value: 2.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  18 EIVAGGALADPAWRAAFEEVPRDLFVPyyfvgrsggyerlwGQDpdparrarwLEGVY-TDMPLAT-RVRDGELLSSSSQ 95
Cdd:TIGR04364  11 ELREDGVIRSPRVEAAFRTVPRHLFAP--------------GAP---------LEKAYaANRAVVTkRDEDGRALSSVSA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  96 PSLMARMLEVLDVRDGHAVLEIGAGtGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGF-RPAVVTGDGARGCP 173
Cdd:TIGR04364  68 PHIQAMMLEQAGVEPGMRVLEIGSG-GYNAALLAELVGpSGEVTTVDIDEDVTDRARACLAAAGYpQVTVVLADAEAGVP 146

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2508023212 174 SRAPFDRIIATCTLPSVPAGWLAQCTPGALIEAPL 208
Cdd:TIGR04364 147 ELAPYDRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
27-241 2.87e-30

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 114.15  E-value: 2.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  27 DPAWRAAFEEVPRDLFVPYYFvgrsggYERLWGQDPDPARRARWLEGVYTdmplatrvrdgellssssqpslMARMLEVL 106
Cdd:PRK00312   23 DERVLEAIEATPRELFVPEAF------KHKAYENRALPIGCGQTISQPYM----------------------VARMTELL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 107 DVRDGHAVLEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHLTAAGFRPAVVT-GDGARGCPSRAPFDRIIATC 185
Cdd:PRK00312   75 ELKPGDRVLEIGTGSGYQAAVLAHLVRR--VFSVERIKTLQWEAKRRLKQLGLHNVSVRhGDGWKGWPAYAPFDRILVTA 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2508023212 186 TLPSVPAGWLAQCTPGALIEAPLATGL--ILLKVRDAGhaqGRFL---HTPAYFVPL-RGVA 241
Cdd:PRK00312  153 AAPEIPRALLEQLKEGGILVAPVGGEEqqLLTRVRKRG---GRFErevLEEVRFVPLvKGEL 211
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 33-239 1.74e-27

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 106.64  E-value: 1.74e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  33 AFEEVPRDLFVPYYfvgrsggYERlwgqdpdparrarwleGVYTDMPLAtrVRDGELLSSSSQpslMARMLEVLDVRDGH 112
Cdd:PRK13942   27 ALLKVPRHLFVPEY-------LEE----------------YAYVDTPLE--IGYGQTISAIHM---VAIMCELLDLKEGM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 113 AVLEIGAGTGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGFRPA-VVTGDGARGCPSRAPFDRIIATCTLPSV 190
Cdd:PRK13942   79 KVLEIGTGSGYHAAVVAEIVGkSGKVVTIERIPELAEKAKKTLKKLGYDNVeVIVGDGTLGYEENAPYDRIYVTAAGPDI 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2508023212 191 PAGWLAQCTPGALIEAPLAT---GLILLKvRDAGHAQGRFLhTPAYFVPLRG 239
Cdd:PRK13942  159 PKPLIEQLKDGGIMVIPVGSysqELIRVE-KDNGKIIKKKL-GEVAFVPLIG 208
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
23-237 4.27e-24

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 97.44  E-value: 4.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  23 GALADPAWRAAFEEVPRDLFVPyyfvgrsggyerlwgqdpdparrARWLEGVYTDMPLATrvrdgELLSSSSQPSLMARM 102
Cdd:pfam01135  14 GVIKSDKVAEAMLAVDREEFVP-----------------------ESFKSYAYEDIPLSI-----GYGQTISAPHMHAMM 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 103 LEVLDVRDGHAVLEIGAGTGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGF-RPAVVTGDGARGCPSRAPFDR 180
Cdd:pfam01135  66 LELLELKPGMRVLEIGSGSGYLTACFARMVGeVGRVVSIEHIPELVEIARRNLEKLGLeNVIVVVGDGRQGWPEFAPYDA 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2508023212 181 IIATCTLPSVPAGWLAQCTPGALIEAPLATG----LILLKVRDAGHAQGRFLhTPAYFVPL 237
Cdd:pfam01135 146 IHVGAAAPEIPEALIDQLKEGGRLVIPVGPNgnqvLQQFDKRNDGSVVIKDL-EGVRFVPL 205
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 71-208 2.02e-21

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 92.60  E-value: 2.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  71 LEGVYTDMPLATrVRDGELLSSSSQPSLMARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGD-GLVTTVDLDPEITES 149
Cdd:PRK13943   42 LSYVYEDIVLVS-YDDGEEYSTSSQPSLMALFMEWVGLDKGMRVLEIGGGTGYNAAVMSRVVGEkGLVVSVEYSRKICEI 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 150 ARTHLTAAGFRPAV-VTGDGARGCPSRAPFDRIIATCTLPSVPAGWLAQCTPGALIEAPL 208
Cdd:PRK13943  121 AKRNVRRLGIENVIfVCGDGYYGVPEFAPYDVIFVTVGVDEVPETWFTQLKEGGRVIVPI 180
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 18-216 6.49e-20

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 86.42  E-value: 6.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  18 EIVAGGALADPAWRAAFEEVPRDLFVPYYFVgrsggyerlwgqdpdparrarwlEGVYTDMPLatRVRDGELLSSSSQps 97
Cdd:TIGR00080  13 KLINEGYIKSKRVIDALLSVPREEFVPEHFK-----------------------EYAYVDTPL--EIGYGQTISAPHM-- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  98 lMARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGFRPAVVT-GDGARGCPSR 175
Cdd:TIGR00080  66 -VAMMTELLELKPGMKVLEIGTGSGYQAAVLAEIVGrDGLVVSIERIPELAEKAERRLRKLGLDNVIVIvGDGTQGWEPL 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2508023212 176 APFDRIIATCTLPSVPAGWLAQCTPGALIEAPLATGLILLK 216
Cdd:TIGR00080 145 APYDRIYVTAAGPKIPEALIDQLKEGGILVMPVGEYLQVLK 185
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 99-238 9.01e-17

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 77.55  E-value: 9.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  99 MARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGFRPAV--VTGDGARGCPSR 175
Cdd:PRK13944   61 VAMMCELIEPRPGMKILEVGTGSGYQAAVCAEAIErRGKVYTVEIVKELAIYAAQNIERLGYWGVVevYHGDGKRGLEKH 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2508023212 176 APFDRIIATCTLPSVPAGWLAQCTPGALIEAPLATGL--ILLKVRDAGHAQGRFLHTPAYFVPLR 238
Cdd:PRK13944  141 APFDAIIVTAAASTIPSALVRQLKDGGVLVIPVEEGVgqVLYKVVKRGEKVEKRAITYVLFVPLR 205
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 100-191 1.18e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 58.85  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 100 ARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRlgDGLVTTVDLDPEITESARTHLTAAGFRPAVVTGDGARGCPSRAPFD 179
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPFPDGSFD 89

                          90
                  ....*....|..
gi 2508023212 180 RIIATCTLPSVP 191
Cdd:COG2226    90 LVISSFVLHHLP 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 114-187 8.36e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.88  E-value: 8.36e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2508023212 114 VLEIGAGTGYNAALLSHRLGdGLVTTVDLDPEITESARTHLTAAGFRPAVVTGDGARGCPSRAPFDRIIATCTL 187
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVL 73
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 99-183 9.84e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.78  E-value: 9.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  99 MARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGdGLVTTVDLDPEITESARTHLTAAGF--RPAVVTGDgARGCPSRA 176
Cdd:COG2230    40 LDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYARERAAEAGLadRVEVRLAD-YRDLPADG 117


                  ....*..
gi 2508023212 177 PFDRIIA 183
Cdd:COG2230   118 QFDAIVS 124
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
111-204 1.14e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 49.05  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 111 GHAVLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFrpavVTGDgARGCPSRAPFDRIIATCTLPSV 190
Cdd:COG4106     2 PRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRF----VVAD-LRDLDPPEPFDLVVSNAALHWL 76

                          90       100
                  ....*....|....*....|
gi 2508023212 191 P------AGWLAQCTPGALI 204
Cdd:COG4106    77 PdhaallARLAAALAPGGVL 96
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 114-179 2.57e-07

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 49.80  E-value: 2.57e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2508023212 114 VLEIGAGTGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGFRPAV--VTGDGARGCP--SRAPFD 179
Cdd:COG4122    20 ILEIGTGTGYSTLWLARALPdDGRLTTIEIDPERAAIARENFARAGLADRIrlILGDALEVLPrlADGPFD 90
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 102-182 1.99e-06

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 47.20  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 102 MLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPA-VVTGDGARGCPSrAPFDR 180
Cdd:pfam05175  23 LLEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGeVVASDVYSGVED-GKFDL 101


                  ..
gi 2508023212 181 II 182
Cdd:pfam05175 102 II 103
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 100-198 3.39e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.78  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 100 ARMLEVLD--VRDGHAVLEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHltAAGFRPAVVTGDGARGCPSRAP 177
Cdd:COG2227    12 RRLAALLArlLPAGGRVLDVGCGTGRLALALARRGAD--VTGVDISPEALEIARER--AAELNVDFVQGDLEDLPLEDGS 87

                          90       100
                  ....*....|....*....|...
gi 2508023212 178 FDRIIATCTLPSV--PAGWLAQC 198
Cdd:COG2227    88 FDLVICSEVLEHLpdPAALLREL 110
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 106-182 4.86e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 47.08  E-value: 4.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 106 LDVRDGHAVLEIGAGTGYNAALLSHRLGD-GLVTTVDLDPEITESARTHLTAAGFRPAVVT--GDGARGCPSRaPFDRII 182
Cdd:COG2519    87 LDIFPGARVLEAGTGSGALTLALARAVGPeGKVYSYERREDFAEIARKNLERFGLPDNVELklGDIREGIDEG-DVDAVF 165
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 114-196 9.34e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.96  E-value: 9.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 114 VLEIGAGTGYNAALLShRLGDGLVTTVDLDPEITESARTHLTAAGFRPA-VVTGDGARG-CPSRAPFDRIIATCTLPSVP 191
Cdd:cd02440     2 VLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVeVLKGDAEELpPEADESFDVIISDPPLHHLV 80


                  ....*
gi 2508023212 192 AGWLA 196
Cdd:cd02440    81 EDLAR 85
PRK14968 PRK14968
putative methyltransferase; Provisional
 102-182 2.28e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 44.50  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 102 MLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHLTAAGFRPA---VVTGD---GARGcpsr 175
Cdd:PRK14968   15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKK--VVGVDINPYAVECAKCNAKLNNIRNNgveVIRSDlfePFRG---- 88


                  ....*..
gi 2508023212 176 APFDRII 182
Cdd:PRK14968   89 DKFDVIL 95
PRK08317 PRK08317
hypothetical protein; Provisional
 100-170 3.02e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 44.54  E-value: 3.02e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2508023212 100 ARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLG-DGLVTTVDLDPEITESARTHLTAAGFRPAVVTGDGAR 170
Cdd:PRK08317    9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRVGpEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADG 80
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 114-282 1.74e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.83  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 114 VLEIGAGTGYNAALLSHRLGdGLVTTVDLDPEITESARTHLTAAGFRPA-VVTGDGARGCP-SRAPFDRIIATCTLPSVP 191
Cdd:COG0500    30 VLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALARARAAKAGLGNVeFLVADLAELDPlPAESFDLVVAFGVLHHLP 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 192 AGWLAQCTpgALIEAPLAT-GLILLKVRDAGHAQGRFLHTPAYFVPLRGVAPAPGTPYTGGLPRPSLENELFRFLLALTA 270
Cdd:COG0500   109 PEEREALL--RELARALKPgGVLLLSASDAAAALSLARLLLLATASLLELLLLLRLLALELYLRALLAAAATEDLRSDAL 186

                         170
                  ....*....|..
gi 2508023212 271 DTLDPYEAYELW 282
Cdd:COG0500   187 LESANALEYLLS 198
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
108-167 5.13e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 40.79  E-value: 5.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2508023212 108 VRDGHAVLEIGAGTGYnAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGF--RPAVVTGD 167
Cdd:COG4076    33 VKPGDVVLDIGTGSGL-LSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLsdRITVINAD 93
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 102-182 6.43e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.17  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 102 MLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPA-VVTGDGARGCPSRaPFDR 180
Cdd:COG2813    41 LLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVeVLWSDGLSGVPDG-SFDL 119


                  ..
gi 2508023212 181 II 182
Cdd:COG2813   120 IL 121
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 99-183 7.89e-04

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 40.25  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  99 MAR-MLEVLDVRdGHAVLEIGAGTGYnAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPAVVTGDgARGCPSRAP 177
Cdd:COG3897    59 LARyLLDHPEVA-GKRVLELGCGLGL-VGIAAAKAGAADVTATDYDPEALAALRLNAALNGVAITTRLGD-WRDPPAAGG 135


                  ....*.
gi 2508023212 178 FDRIIA 183
Cdd:COG3897   136 FDLILG 141
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 102-182 1.33e-03

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 39.07  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 102 MLEVLDVRDGHAVLEIGAGTGYNAALLSHRlGDgLVTTVDLDPEITESARTHLTAAGFRPAVVTGDGARgcPSRAPFDRI 181
Cdd:TIGR00537  11 LEANLRELKPDDVLEIGAGTGLVAIRLKGK-GK-CILTTDINPFAVKELRENAKLNNVGLDVVMTDLFK--GVRGKFDVI 86


                  .
gi 2508023212 182 I 182
Cdd:TIGR00537  87 L 87
PRK14967 PRK14967
putative methyltransferase; Provisional
 99-192 1.46e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.27  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  99 MARMLEVLDVRDGHAVLEIGAGTGYnAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPAVVTGDGARGCPSRaPF 178
Cdd:PRK14967   25 LADALAAEGLGPGRRVLDLCTGSGA-LAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVDVDVRRGDWARAVEFR-PF 102

                          90
                  ....*....|....
gi 2508023212 179 DriIATCTLPSVPA 192
Cdd:PRK14967  103 D--VVVSNPPYVPA 114
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
114-193 1.82e-03

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 38.66  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 114 VLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHL--TAAGFRPA---VVTGDGA---RGCPSRapFDRIIATC 185
Cdd:COG0421    41 VLIIGGGDGGLARELLKHPPVERVDVVEIDPEVVELAREYFplLAPAFDDPrlrVVIGDGRaflREAEES--YDVIIVDL 118


                  ....*...
gi 2508023212 186 TLPSVPAG 193
Cdd:COG0421   119 TDPVGPAE 126
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
62-170 3.28e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 37.96  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212  62 PDPARRARWLEGVYTDMPLAtrvrdgellssssqpslmARMLEVLDVR---DGHAVLEIGAGTGYnAALLSHRLGDGLVT 138
Cdd:COG2263    12 PGFSNPKVELEQYPTPAELA------------------AELLHLAYLRgdiEGKTVLDLGCGTGM-LAIGAALLGAKKVV 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2508023212 139 TVDLDPEITESARTHLTAAGFRPAVVTGDGAR 170
Cdd:COG2263    73 GVDIDPEALEIARENAERLGVRVDFIRADVTR 104
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 115-159 5.48e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 35.72  E-value: 5.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2508023212 115 LEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHLTAAGF 159
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREKAPREGL 43
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
100-235 5.84e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 37.29  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 100 ARMLEVLDVRDGHAVLEIGAGTGYNAALLSHRLGDglVTTVDLDPEITESARTHLTAAgfrpAVVTGDGARGCPSRAPFD 179
Cdd:COG4976    36 EELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR--LTGVDLSEEMLAKAREKGVYD----RLLVADLADLAEPDGRFD 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2508023212 180 RIIATCTLPSVPAgwLAQCTPGALiEApLATGLILLKVRDAGHAQGRFLHTPAYFV 235
Cdd:COG4976   110 LIVAADVLTYLGD--LAAVFAGVA-RA-LKPGGLFIFSVEDADGSGRYAHSLDYVR 161
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 115-204 8.65e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.04  E-value: 8.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 115 LEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGFRPAVVT--GDGARGCPSRAPFDRIIATCTL--PSV 190
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVelFQLDLGELDPGSFDVVVASNVLhhLAD 80

                          90
                  ....*....|....*...
gi 2508023212 191 PAGWLAQC----TPGALI 204
Cdd:pfam08242  81 PRAVLRNIrrllKPGGVL 98
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 114-158 8.83e-03

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 36.71  E-value: 8.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2508023212 114 VLEIGAGTGYNAALLSHRL-GDGLVTTVDLDPEITESARTHLTAAG 158
Cdd:pfam01596  47 VLEIGVFTGYSALAMALALpEDGKITAIDIDPEAYEIAKKFIQKAG 92
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 107-183 9.01e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 37.05  E-value: 9.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508023212 107 DVRDGHAVLEIGAGTGYNAALLSHRLGDGLVTTVDLDPEITESARTHLTAAGF--RPAVVTGD----GARGCPSRapFDR 180
Cdd:COG4123    34 PVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLedRITVIHGDlkefAAELPPGS--FDL 111


                  ...
gi 2508023212 181 IIA 183
Cdd:COG4123   112 VVS 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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