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Conserved domains on  [gi|2495259862|ref|WP_279631248|]
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MFS transporter [Rathayibacter sp. VKM Ac-2762]

Protein Classification

MFS transporter( domain architecture ID 1001490)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  9529885|26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10504 super family cl32521
putative transporter; Provisional
 2-388 2.92e-75

putative transporter; Provisional


The actual alignment was detected with superfamily member PRK10504:

Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 243.10  E-value: 2.92e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:PRK10504   14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:PRK10504   94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAfAIARRIVPATAESAPPPLDVTGLVLVAVGLGALVGAAGLLTDSELDGRAVAPM-LVGAAVTALAVRHLRRAENPL 240
Cdd:PRK10504  174 GIIG-AIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLvAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 241 VRLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVA 320
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495259862 321 ASAVGAACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL 400
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 2-388 2.92e-75

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 243.10  E-value: 2.92e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:PRK10504   14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:PRK10504   94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAfAIARRIVPATAESAPPPLDVTGLVLVAVGLGALVGAAGLLTDSELDGRAVAPM-LVGAAVTALAVRHLRRAENPL 240
Cdd:PRK10504  174 GIIG-AIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLvAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 241 VRLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVA 320
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495259862 321 ASAVGAACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL 400
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 7-436 1.31e-65

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 215.13  E-value: 1.31e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   7 FFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTL 86
Cdd:cd17503     5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  87 PLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAF 166
Cdd:cd17503    85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 167 AIArrivpataesapppldvtglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrhlrraenPLVRLDAF 246
Cdd:cd17503   165 LLA---------------------------------------------------------------------PLLDLRLF 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 247 RFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASAVGA 326
Cdd:cd17503   176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 327 ACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI---------------AAG 391
Cdd:cd17503   256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLggsigtallatlltnRTQ 335

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 2495259862 392 LGVAVGAVALAVGTAIGPGLVPYRVAFLALAVLTLVPLAAAARLP 436
Cdd:cd17503   336 FHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 8-388 2.25e-52

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 182.96  E-value: 2.25e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   8 FMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLP 87
Cdd:TIGR00711  12 FMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  88 LLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFA 167
Cdd:TIGR00711  92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 168 IARRIVPATAESAPPPLDVTGLVLVAVGLGALV------GAAGLLTDSELdgraVAPMLVGAAVTALAVRHLRRAENPLV 241
Cdd:TIGR00711 172 VAFFILPRDKPAASENFDFLGLLLLSVGLGSLLyglsegPERGWFDSNEI----LILSITGLVAIIAFVVWELTDDNPLV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 242 RLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAA 321
Cdd:TIGR00711 248 DLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIG 327

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495259862 322 SAVGAACMAAMAF-LDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:TIGR00711 328 LILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-388 2.44e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 117.38  E-value: 2.44e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:COG2814    14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAFAIARRIVPATAESAPPPLDVTglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrhlrraenplv 241
Cdd:COG2814   174 ALLALLLLLRLLPESRPAARARLRGS------------------------------------------------------ 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 242 RLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAA 321
Cdd:COG2814   200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495259862 322 SAVGAACMAAMAFldpATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:COG2814   280 LLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_1 pfam07690
Major Facilitator Superfamily;
2-388 3.89e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.94  E-value: 3.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAFAIARRIVPATAESAPPPLDVTGLVLVAVGlgalvgaaglltdSELDGRAVAPMLVGAAVTALAvrhlrraenplv 241
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW-------------KALLRDPVLWLLLALLLFGFA------------ 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 242 rldafrfrtfrvanasgslyratVNAVPFLLPlLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAA 321
Cdd:pfam07690 216 -----------------------FFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495259862 322 SAVGAACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 2-388 2.92e-75

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 243.10  E-value: 2.92e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:PRK10504   14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:PRK10504   94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAfAIARRIVPATAESAPPPLDVTGLVLVAVGLGALVGAAGLLTDSELDGRAVAPM-LVGAAVTALAVRHLRRAENPL 240
Cdd:PRK10504  174 GIIG-AIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLvAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 241 VRLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVA 320
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495259862 321 ASAVGAACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL 400
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 7-436 1.31e-65

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 215.13  E-value: 1.31e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   7 FFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTL 86
Cdd:cd17503     5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  87 PLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAF 166
Cdd:cd17503    85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 167 AIArrivpataesapppldvtglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrhlrraenPLVRLDAF 246
Cdd:cd17503   165 LLA---------------------------------------------------------------------PLLDLRLF 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 247 RFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASAVGA 326
Cdd:cd17503   176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 327 ACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI---------------AAG 391
Cdd:cd17503   256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLggsigtallatlltnRTQ 335

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 2495259862 392 LGVAVGAVALAVGTAIGPGLVPYRVAFLALAVLTLVPLAAAARLP 436
Cdd:cd17503   336 FHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 8-388 2.25e-52

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 182.96  E-value: 2.25e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   8 FMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLP 87
Cdd:TIGR00711  12 FMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  88 LLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFA 167
Cdd:TIGR00711  92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 168 IARRIVPATAESAPPPLDVTGLVLVAVGLGALV------GAAGLLTDSELdgraVAPMLVGAAVTALAVRHLRRAENPLV 241
Cdd:TIGR00711 172 VAFFILPRDKPAASENFDFLGLLLLSVGLGSLLyglsegPERGWFDSNEI----LILSITGLVAIIAFVVWELTDDNPLV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 242 RLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAA 321
Cdd:TIGR00711 248 DLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIG 327

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495259862 322 SAVGAACMAAMAF-LDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:TIGR00711 328 LILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 7-436 1.08e-34

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 132.68  E-value: 1.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   7 FFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTL 86
Cdd:cd17321     5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  87 PLLVGARVLQGVGGALMVPVGrLAVLRAT-PREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVA 165
Cdd:cd17321    85 AFLIAARALQGIGAAAIMPAS-LALIAATfPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 166 FAIArrivpataesapppldvtglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrhlrraenplvrlda 245
Cdd:cd17321   164 LLLA---------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 246 frfRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASAVG 325
Cdd:cd17321   168 ---RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 326 AACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI---------------AA 390
Cdd:cd17321   245 AVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLggalgvallgalltaGL 324

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 2495259862 391 GLGVAVGAVALAVGTAIGPGLVPYRVAFLALAVLTLVPLAAAARLP 436
Cdd:cd17321   325 SANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 8-172 2.30e-33

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 128.06  E-value: 2.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   8 FMENLDATIVTTAAPAIAADLGvDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLP 87
Cdd:cd17502     6 FLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  88 LLVGARVLQGVGGALMVPVGRLAV-LRATPRE-GIIHAIAILVWpgLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVA 165
Cdd:cd17502    85 MLIVGRAIQGIGGGGLMSLAFIIIaDLVPPRErGKYQGYIGAVF--GIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLA 162


                  ....*..
gi 2495259862 166 FAIARRI 172
Cdd:cd17502   163 LALLRTI 169
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-388 2.44e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 117.38  E-value: 2.44e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:COG2814    14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAFAIARRIVPATAESAPPPLDVTglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrhlrraenplv 241
Cdd:COG2814   174 ALLALLLLLRLLPESRPAARARLRGS------------------------------------------------------ 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 242 RLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAA 321
Cdd:COG2814   200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495259862 322 SAVGAACMAAMAFldpATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:COG2814   280 LLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 2-276 7.61e-25

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 103.74  E-value: 7.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:COG0477    18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:COG0477    98 LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAFAIARRIVPATAESAPPPLDVTGLVLVAVGLGALVGAAGLLTDSELDGRAVAPMLVGAAVTALAVRHLRRAENPLV 241
Cdd:COG0477   178 GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALL 257

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2495259862 242 RLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLF 276
Cdd:COG0477   258 LLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 8-436 2.33e-22

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 98.03  E-value: 2.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   8 FMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLP 87
Cdd:cd17504     6 LAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  88 LLVGARVLQGVGGAlMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFA 167
Cdd:cd17504    86 VLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 168 IArrivpataesapppldvtglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrhlrraenPLVRLDAFR 247
Cdd:cd17504   165 LV---------------------------------------------------------------------PLIDLRLLR 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 248 FRTFRVANASGSLYRATVNAVPFLLPLLFQDA----FGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASA 323
Cdd:cd17504   176 RRNVLLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 324 VGAACMAAMAFLdpATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQIAAGLGVAVGAVALAV 403
Cdd:cd17504   256 ISAVGLLLLALL--HSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTT 333

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2495259862 404 GTAIG-----PGLVPYRVAFLALAVLTLVPLAAAARLP 436
Cdd:cd17504   334 YTVSItsggvPTEGAYVLAFLIGAALALAALLLSLLIP 371
PRK14995 PRK14995
SmvA family efflux MFS transporter;
12-378 2.51e-22

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 99.03  E-value: 2.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  12 LDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVG 91
Cdd:PRK14995   20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  92 ARVLQGVGGALMVPvGRLAVLRATPREGIIHAIAILVWP--GLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIA 169
Cdd:PRK14995  100 TRALLAIGAAMIVP-ATLAGIRATFTEEKQRNMALGVWAavGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 170 RRIVPATAESAPPPLDVT-GLVLVAVGLGALVGAAGLLTDSELDGRAVAPMLVGAAVTALAVRHLRRAENPLVRLDAFRF 248
Cdd:PRK14995  179 ARYVPRQAGRRDQPLNLGhALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTH 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 249 RTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASAVGAAC 328
Cdd:PRK14995  259 RIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALS 338

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2495259862 329 MAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGA 378
Cdd:PRK14995  339 FYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAA 388
MFS_1 pfam07690
Major Facilitator Superfamily;
2-388 3.89e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.94  E-value: 3.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 162 GVVAFAIARRIVPATAESAPPPLDVTGLVLVAVGlgalvgaaglltdSELDGRAVAPMLVGAAVTALAvrhlrraenplv 241
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW-------------KALLRDPVLWLLLALLLFGFA------------ 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 242 rldafrfrtfrvanasgslyratVNAVPFLLPlLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAA 321
Cdd:pfam07690 216 -----------------------FFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495259862 322 SAVGAACMAAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQI 388
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 15-177 1.41e-18

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 86.86  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARV 94
Cdd:cd17320    16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  95 LQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVP 174
Cdd:cd17320    96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP 175


                  ...
gi 2495259862 175 ATA 177
Cdd:cd17320   176 ETL 178
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 15-183 6.98e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 84.93  E-value: 6.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARV 94
Cdd:cd17474    16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  95 LQGVGGALMVP-----VGRLAVLRATPREGIIHAIAIlvwpgLVAPVIAPFLGGLLTTVaSWHWIFLINLPLGVVAFAIA 169
Cdd:cd17474    96 LQGIGAAGLGPlaltlIGDLFEGGERAKAMGLYEAAL-----GLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAI 169

                         170
                  ....*....|....
gi 2495259862 170 RRIVPATAESAPPP 183
Cdd:cd17474   170 LFLLPEPKEKAKSS 183
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 5-176 8.96e-18

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 84.74  E-value: 8.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   5 GCFFM-ENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALS 83
Cdd:TIGR00710  11 GCLSIlGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  84 PTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGV 163
Cdd:TIGR00710  91 NNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGI 170

                         170
                  ....*....|...
gi 2495259862 164 VAFAIARRIVPAT 176
Cdd:TIGR00710 171 LLSALIFFILPET 183
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 7-375 1.18e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 81.08  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   7 FFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTL 86
Cdd:cd17325     5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  87 PLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAF 166
Cdd:cd17325    85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 167 AIARRIVPATAESAPPpldvtglvlvavglgalvgaaglltdseldgravapmlvgaavtalavRHLRRAENPLVRLDAF 246
Cdd:cd17325   165 VLALLLLPEPRPPPNK------------------------------------------------RAVSAARLRSGLRLLL 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 247 RFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASAVGA 326
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2495259862 327 ACMAAMAFldpATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGM 375
Cdd:cd17325   277 VALLLLPL---ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGR 322
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
2-169 1.23e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 81.07  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:COG2271    14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:COG2271    94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP 173


                  ....*...
gi 2495259862 162 GVVAFAIA 169
Cdd:COG2271   174 GLLLALLR 181
2_A_01_02 TIGR00880
Multidrug resistance protein;
36-176 4.88e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.91  E-value: 4.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  36 SITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMVPVGRLAVLRAT 115
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2495259862 116 PREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPAT 176
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 14-174 1.41e-14

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 74.92  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  14 ATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGAR 93
Cdd:cd17323    15 SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  94 VLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIV 173
Cdd:cd17323    95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL 174


                  .
gi 2495259862 174 P 174
Cdd:cd17323   175 P 175
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 22-205 2.36e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 74.12  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  22 PAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGA 101
Cdd:cd17324    23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 102 LMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPATAESAP 181
Cdd:cd17324   103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182

                         170       180
                  ....*....|....*....|....
gi 2495259862 182 PPLDVTGLVLVAVGLGALVGAAGL 205
Cdd:cd17324   183 GSLGLLSSLLLLLRNPRLRLAYLI 206
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
20-179 1.15e-13

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 72.28  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  20 AAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVG 99
Cdd:PRK15402   35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 100 GALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPATAES 179
Cdd:PRK15402  115 LCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGR 194
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 12-174 2.06e-13

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 71.06  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  12 LDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVG 91
Cdd:cd17319    17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  92 ARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARR 171
Cdd:cd17319    97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF 176


                  ...
gi 2495259862 172 IVP 174
Cdd:cd17319   177 YLR 179
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
20-176 1.47e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 68.79  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  20 AAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVG 99
Cdd:PRK11102   13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495259862 100 GALMVPVGRlAVLRAT-PREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPAT 176
Cdd:PRK11102   93 AAAASVVIN-ALMRDMfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 15-170 2.14e-12

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 68.06  E-value: 2.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARV 94
Cdd:cd17476    15 GSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRA 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2495259862  95 LQGVGGALMVPVGrLAVLRATPREGIIHAIAILVWpGLVAPV---IAPFLGGLLTTVASWHWIFLINLPLGVVAFAIAR 170
Cdd:cd17476    95 LQGLGPAFLLPNA-MALLGRTYPPGPRKNIVFSLF-GATAPLgfaLGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAI 171
emrD PRK11652
multidrug transporter EmrD;
15-171 3.76e-12

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 67.62  E-value: 3.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARV 94
Cdd:PRK11652   25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  95 LQG----VGGALMvpvgrlavlRATPR-----EGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGV-V 164
Cdd:PRK11652  105 IQGlgtgVGGVMA---------RTLPRdlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAgV 175


                  ....*..
gi 2495259862 165 AFAIARR 171
Cdd:PRK11652  176 TFSMARW 182
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
6-335 4.26e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 67.21  E-value: 4.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   6 CFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPT 85
Cdd:COG2223    13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  86 LPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVA 165
Cdd:COG2223    93 YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVV 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 166 FAIARRIVPATAESAPPPldvtglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrhlrRAENPLVRLDA 245
Cdd:COG2223   173 AVLAWLFLRDPPAGAAAA---------------------------------------------------AKASLRDQLEA 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 246 FRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASAVG 325
Cdd:COG2223   202 LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM 281

                         330
                  ....*....|
gi 2495259862 326 AACMAAMAFL 335
Cdd:COG2223   282 ALGLLLLALA 291
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 3-426 3.21e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 64.76  E-value: 3.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   3 VAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCAL 82
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  83 SPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTT--VASWHWIFLINLP 160
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 161 LGVVAFAIARRIVPATAESAPPPLDVTGLVLVAVGLGALvgaaglltdseldgravapmlvgaavtalavrhlrraenpl 240
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV----------------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 241 vrldaFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVA 320
Cdd:cd06174   200 -----LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 321 ASAVGAACmaAMAFLDPATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQEGMSGANTLNATTQQIAAGLGVAVGAVA 400
Cdd:cd06174   275 IGLLLMAL--GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352

                         410       420
                  ....*....|....*....|....*.
gi 2495259862 401 LAVGTAIGPGLVPYRVAFLALAVLTL 426
Cdd:cd06174   353 LAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 15-337 5.38e-11

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 64.57  E-value: 5.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIAADLGvDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARV 94
Cdd:cd06179    15 TLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  95 LQGVGGALmVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLT--TVASWHWIFLINLPLGVVAFAI---- 168
Cdd:cd06179    94 LIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALALILlfff 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 169 -----ARRIVPATAESAPPPLDVTGLVLVAVGLGALVGAAGLLTDSE--LDGRAVAPMLVG-AAVTALAVRHLR-RAENP 239
Cdd:cd06179   173 yhpppRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYpwSSAHVIAPLVIGgVLLIAFGLYEWKgTKDGL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 240 LVRLDAFRFRTFR----VANASGSLYRATVNAVPFLLPLLfqdaFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLG-F 314
Cdd:cd06179   253 LPPRLLFRGRNFAliliVAFVEGMIFYSLNIFWPQQISLL----FTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKhI 328

                         330       340
                  ....*....|....*....|...
gi 2495259862 315 RGVLVAASAVGAACMAAMAFLDP 337
Cdd:cd06179   329 KWQLVAGFVLFTAFLALLALITP 351
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 22-206 1.15e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.00  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  22 PAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGA 101
Cdd:cd17489    20 PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 102 LMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPATAESAP 181
Cdd:cd17489   100 AFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAE 179

                         170       180
                  ....*....|....*....|....*
gi 2495259862 182 PPLDVTGLVLVAVGLGALVGAAGLL 206
Cdd:cd17489   180 EAEAGTRAFRRLVEKKVLPPALILF 204
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 6-167 1.32e-10

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 62.74  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   6 CFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPT 85
Cdd:TIGR00893   2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  86 LPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLI----NLPL 161
Cdd:TIGR00893  82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIegvlGIIW 161


                  ....*.
gi 2495259862 162 GVVAFA 167
Cdd:TIGR00893 162 GVLWLK 167
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
19-183 2.67e-10

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 61.96  E-value: 2.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  19 TAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGV 98
Cdd:PRK10473   24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  99 G-GALMVPVgrLAVLRAT-PREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPAT 176
Cdd:PRK10473  104 GaGCCYVVA--FAILRDTlDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKET 181


                  ....*..
gi 2495259862 177 AESAPPP 183
Cdd:PRK10473  182 RPARAPA 188
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 2-178 6.03e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.83  E-value: 6.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCF---FMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASL 78
Cdd:TIGR00895  18 AIILSFlimLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  79 LCALSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATP--REGIIHAIAILVWPglVAPVIAPFLGGLLTTVASWHWIFL 156
Cdd:TIGR00895  98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPkrFRGTAVGLMFCGYP--IGAAVGGFLAGWLIPVFGWRSLFY 175

                         170       180
                  ....*....|....*....|..
gi 2495259862 157 INLPLGVVAFAIARRIVPATAE 178
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFLPESID 197
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 12-174 1.34e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 59.56  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  12 LDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVG 91
Cdd:cd17328    13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  92 ARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVA-SWHWIFLINLPLGVVAFAIAR 170
Cdd:cd17328    93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLL 172


                  ....
gi 2495259862 171 RIVP 174
Cdd:cd17328   173 LFVR 176
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 7-173 1.57e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 59.15  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   7 FFMENLDATIVTTAAPAIAADLGVDSAAvSITVTAFLLTVAVLIPAS---GWLSERFGVRRVFTSAIAVFTLASLLCALS 83
Cdd:cd17316     8 WFFDAYDFFLIGFVAPVLAAEFSLGLSL-LQTGLLFAAGFLGRPIGAllfGYLGDRIGRKKALILTLLLFGLATLLIGLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  84 PTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAIL----VWPGLVAPVIAPFLGGLLTTVASWHWIFLINL 159
Cdd:cd17316    87 PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRILFLIGA 166

                         170
                  ....*....|....
gi 2495259862 160 PLGVVAFAIARRIV 173
Cdd:cd17316   167 LPALLALLLRRRTL 180
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 1-170 1.00e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 56.82  E-value: 1.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   1 MLVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLC 80
Cdd:cd17365     2 ALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  81 ALSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLP 160
Cdd:cd17365    82 AFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGV 161

                         170
                  ....*....|
gi 2495259862 161 LGVVAFAIAR 170
Cdd:cd17365   162 PPLILLPLLR 171
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
26-183 6.23e-08

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 54.45  E-value: 6.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  26 ADLGVDSAAVSITVTAFLLTVAVLIPasgwLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMVP 105
Cdd:PRK15403   48 ADVSLAPASVSLYLAGGMALQWLLGP----LSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIAT 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495259862 106 VGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPATAESAPPP 183
Cdd:PRK15403  124 VGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVP 201
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
2-335 1.33e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 53.32  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:COG0738    12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVP-----VGRLAVLRATPREGIIHAIailvWPglVAPVIAPFLGGLLTTV---ASWHW 153
Cdd:COG0738    92 LAPSYPLLLLALFLLGLGLGLLDVaanpyVAALGPETAASRLNLLHAF----FS--LGALLGPLLGGLLILLglsLSWHL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 154 IFLIN-LPLGVVAFAIARRIVPATAESAPPpldvtglvlvavglgalvgaaglltdseldgravapmlvgaavtalavrh 232
Cdd:COG0738   166 PYLILaVLLLLLALLFLRSKLPEIEEEEEE-------------------------------------------------- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 233 lrRAENPLVRLDAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRL 312
Cdd:COG0738   196 --AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF 273

                         330       340
                  ....*....|....*....|...
gi 2495259862 313 GFRGVLVAASAVGAACMAAMAFL 335
Cdd:COG0738   274 GPVRLLRLSALLAAVGLLLALLA 296
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 28-173 1.39e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.35  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  28 LGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMVPVG 107
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2495259862 108 RLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIV 173
Cdd:cd17325   310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
23-187 3.98e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 51.82  E-value: 3.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  23 AIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGgal 102
Cdd:PRK11043   31 AIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG--- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 103 mvpVGRLAVlratpregIIHAIAILVWPG------------LVA--PVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAI 168
Cdd:PRK11043  108 ---VCSAAV--------IWQALVIDRYPAqkanrvfatimpLVAlsPALAPLLGAWLLNHFGWQAIFATLFAITLLLILP 176

                         170
                  ....*....|....*....
gi 2495259862 169 ARRIVPATAESAPPPLDVT 187
Cdd:PRK11043  177 TLRLKPSKKARKQSQDALT 195
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 15-203 4.80e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 4.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIA-ADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGAR 93
Cdd:cd17473    16 AAIAPALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  94 VLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVaSWHWIFLINLPLGVVAFAIA---- 169
Cdd:cd17473    96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLlflp 174

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2495259862 170 ----RRIVPATAESAPPPLDVTGLVLVAVGLGALVGAA 203
Cdd:cd17473   175 eparKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLL 212
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
15-183 6.08e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.41  E-value: 6.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARV 94
Cdd:COG2807    35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  95 LQGVGGALMVPVGRLAVLRATPRE-GIIHAIAILVWP--GLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARR 171
Cdd:COG2807   115 LIGAGIAVGNVLLPGLIKRWFPDRvGLMTGLYTAAMGlgAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR 194

                         170
                  ....*....|..
gi 2495259862 172 IVPATAESAPPP 183
Cdd:COG2807   195 RPAAAAAAPAAA 206
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 12-170 7.37e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 51.15  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  12 LDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVG 91
Cdd:cd17371    13 FDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  92 ARVLQGVGGALMVPVGR--LAVLRATPREGIIHAIAILVWP--GLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFA 167
Cdd:cd17371    93 LRALAGLGFGGEWAAGAalMAEYVPARHRGKALGYVQSGWAvgWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLF 172


                  ...
gi 2495259862 168 IAR 170
Cdd:cd17371   173 IRR 175
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 27-183 2.69e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  27 DLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMVPV 106
Cdd:cd17329    29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495259862 107 GRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLtTVASWHWIFLINLPLGVVAFAIARRIVPATAESAPPP 183
Cdd:cd17329   109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 35-175 3.87e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 48.75  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  35 VSITVTAFLLTVAVL-IPAsGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQG---VGGALMVPVGRLa 110
Cdd:cd17472    34 IGLALGIYGLTQAIFqIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGsgaISSVVMALLADL- 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2495259862 111 vlraTPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPA 175
Cdd:cd17472   112 ----TREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD 172
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 13-101 6.07e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 48.33  E-value: 6.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  13 DATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGA 92
Cdd:cd17359    16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95

                          90
                  ....*....|.
gi 2495259862  93 RVLQG--VGGA 101
Cdd:cd17359    96 RIIGGlaVGGA 106
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 15-373 8.66e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.61  E-value: 8.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  15 TIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRV-----FTSAIAVFTLASLLCALSPTLPLL 89
Cdd:cd06173    16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  90 VGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIA 169
Cdd:cd06173    96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 170 RRIVPATAESAPPPLDVTGLVLVAVGLgalvgaaglltdseldgravapmlvgaavtalavrhlRRAENPLVRLDAFrfr 249
Cdd:cd06173   176 LFIRRPPPAAPGESSSLLLRDLREGLR-------------------------------------YLRRSPLLRLLLL--- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 250 tfrvanaSGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLALFAGNLAIKPATTPLLRRLGFRGVLVAASAVGAACM 329
Cdd:cd06173   216 -------ALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2495259862 330 AAMAFldpATPVALVVALLVLSGVARSAGFTAYNTVTFAEVPQE 373
Cdd:cd06173   289 LVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE 329
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-168 1.25e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.20  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   1 MLVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAflLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLC 80
Cdd:cd17489   197 LPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYA--IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  81 ALSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLP 160
Cdd:cd17489   275 SFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAV 354


                  ....*...
gi 2495259862 161 LGVVAFAI 168
Cdd:cd17489   355 VVLLALVL 362
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 6-176 1.43e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 46.78  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   6 CFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLC--ALS 83
Cdd:cd17380     7 ATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTplLAY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  84 PTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGV 163
Cdd:cd17380    87 SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGL 166

                         170
                  ....*....|...
gi 2495259862 164 VAFAIARRIVPAT 176
Cdd:cd17380   167 LWALVWLIYLPPV 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-178 1.98e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   1 MLVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAI--AVFTLASL 78
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIglLLAALALL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  79 LCALSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLIN 158
Cdd:COG2271   264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343

                         170       180
                  ....*....|....*....|
gi 2495259862 159 LPLGVVAFAIARRIVPATAE 178
Cdd:COG2271   344 AALALLAALLALLLLRETRK 363
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 9-99 2.03e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 46.49  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   9 MENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPL 88
Cdd:PRK11551   26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105

                          90
                  ....*....|.
gi 2495259862  89 LVGARVLQGVG 99
Cdd:PRK11551  106 LLVARLLTGVG 116
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 35-107 2.80e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.03  E-value: 2.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2495259862  35 VSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMVPVG 107
Cdd:cd17317    27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG 99
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 25-181 5.13e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 45.29  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  25 AADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFT-LASLLCALSPTLPLLVGARVLQGVGGALM 103
Cdd:cd17490    23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGIAAATW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 104 VPvgrLAVLRAT--PREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPATAESAP 181
Cdd:cd17490   103 VS---FTVLYASyfPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKP 179
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 7-169 6.99e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 44.93  E-value: 6.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   7 FFMENLDATIVTTAAPA-IAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPT 85
Cdd:cd17327    14 YFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  86 LPLLVGARVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLG-GLLT-----TVASWHWIFLINl 159
Cdd:cd17327    94 FGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvgGLAGWRWLFIIE- 172

                         170
                  ....*....|
gi 2495259862 160 plGVVAFAIA 169
Cdd:cd17327   173 --GLITIIIG 180
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 35-106 2.73e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 43.03  E-value: 2.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2495259862  35 VSITVTAFLLTVAVlipaSGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVG---GALMVPV 106
Cdd:cd17360    41 VSSTVAGAAVGAAI----GGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvgiASMTVPL 111
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 22-174 3.66e-04

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 42.39  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  22 PAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGA 101
Cdd:PRK10091   27 TELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPHG 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2495259862 102 LMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVP 174
Cdd:PRK10091  107 AFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVP 179
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 25-174 3.75e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.57  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  25 AADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALmV 104
Cdd:cd17330    26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-V 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 105 PVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVP 174
Cdd:cd17330   105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
2-172 3.94e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.53  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:COG0738   215 GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGRLAVLRATPREGiIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPL 161
Cdd:COG0738   295 LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373

                         170
                  ....*....|.
gi 2495259862 162 GVVAFAIARRI 172
Cdd:COG0738   374 YLLILLLALAL 384
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 27-172 4.22e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.17  E-value: 4.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  27 DLGVDSAAVSITVTAFLLTVAVLIPASG-WLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMVP 105
Cdd:cd17474   228 LYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495259862 106 VGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRI 172
Cdd:cd17474   308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 18-185 4.61e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 42.36  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  18 TTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQG 97
Cdd:TIGR00881  15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  98 -VGGALMVPVGRLAVLRATPRE----GIIHAIAILVWPGLVAPVIAPFLGGLLttvaSWHWIFLINLPLG-VVAFAIARR 171
Cdd:TIGR00881  95 iFQGMGWPPCGRTVTKWFSRSErgtwVSFWNCSHNVGGGLLPPLVLFGIAELY----SWHWVFIVPGIIAiIVSLICFLL 170

                         170
                  ....*....|....
gi 2495259862 172 IVPATAESAPPPLD 185
Cdd:TIGR00881 171 LRDSPQSCGLPPAE 184
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 18-168 4.68e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 42.26  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  18 TTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQG 97
Cdd:cd17312    23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2495259862  98 -VGGALMVPVGRLAVLRATPRE-GIIHAIailvWPGL--VAPVIAPFLGGLLTTVASWHWIFLINlPLGVVAFAI 168
Cdd:cd17312   103 lFQSMGWPPCVKLLGNWFSKKErGTVYGI----WSTShnFGGILAPILAASLASYYGWRAAFLVP-GIVGLVVAI 172
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-180 4.91e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.17  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCA 81
Cdd:COG2807   219 LLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGL 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  82 LSPTLPLLVGARVLQGVGGALMVPVGR-LAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLL-TTVASWHWIFLINL 159
Cdd:COG2807   299 LLAPGSLPWLWAVLLGLGQGGLFPLALtLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALhDATGSWTAALLLLA 378

                         170       180
                  ....*....|....*....|.
gi 2495259862 160 PLGVVAFAIARRIVPATAESA 180
Cdd:COG2807   379 ALAVLMLVAGLLAGRPYVEDA 399
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 16-184 5.69e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.78  E-value: 5.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  16 IVTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVL 95
Cdd:cd17477    14 LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  96 QGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTV-ASWHWIFLINLPLGVVAFAIARRIVP 174
Cdd:cd17477    94 MGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAgALPFLIAAVLLLLALVPLLLTRRAAP 173

                         170
                  ....*....|
gi 2495259862 175 ATAESAPPPL 184
Cdd:cd17477   174 EIEEAESISL 183
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 22-182 1.05e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  22 PAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGA 101
Cdd:cd17478    20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 102 LMVPVG-RLAVLRATPREGIihAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRIVPATAESA 180
Cdd:cd17478   100 AFHPEGaRLASQAAGGRRGL--AMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177


                  ..
gi 2495259862 181 PP 182
Cdd:cd17478   178 KK 179
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 22-103 1.27e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 40.70  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  22 PAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGA 101
Cdd:cd17393    23 PAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANG 102


                  ..
gi 2495259862 102 LM 103
Cdd:cd17393   103 AL 104
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 2-204 1.53e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 40.72  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862   2 LVAGCFFMENLDATIVTTAAP---AIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASL 78
Cdd:cd17355     4 VLAVTFLILILSWGIRYYFGVfiiPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  79 LCALSPTLPLLVGARVLQGVGGALMVPVGRLAVL-RATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLI 157
Cdd:cd17355    84 LLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2495259862 158 -NLPLGVVAFAIARRIVPATAESAPPPLDVTGLVLVAVGLGALVGAAG 204
Cdd:cd17355   164 lALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSAS 211
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 19-165 1.92e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 40.42  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  19 TAAPAIAADLGvDSAAVSITVTAFLLTVAVLIPASGWLSERFGvRRVFTSAIAVFTLASLLCALSPT-LPLLVGARVLQG 97
Cdd:pfam06609  65 SALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFG-RRPFVIATHIIGLVGAIVGCTANkFNTLLAAMTLLG 142

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2495259862  98 VG----GALMVPVGRLaVLRATPREGIIhaiaILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVA 165
Cdd:pfam06609 143 VAagpaGASPLFIGEL-MSNKTKFLGLL----IVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIA 209
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 31-180 2.02e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.38  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  31 DSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMVPVGRLA 110
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVL 204

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2495259862 111 VLRATPRE--GIIHAIAILVW-PGLVapviapFLGGLLTTVASWHWI-FLINLPLgvVAFAIARRIVPataESA 180
Cdd:TIGR00898 205 NTEFLPKKqrAIVGTLIQVFFsLGLV------LLPLVAYFIPDWRWLqLAVSLPT--FLFFLLSWFVP---ESP 267
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
219-340 2.74e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 219 MLVGAAVTALAVRHLRRAENPLVRL-----DAFRFRTFRVANASGSLYRATVNAVPFLLPLLFQDAFGWSPVQAGSVVLA 293
Cdd:COG2211   193 GLLAFLLTFFGTKERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLAL 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2495259862 294 LFAGNLAIKPATTPLLRRLGFRGVLVAASAVGAACMAAMAFLDPATP 340
Cdd:COG2211   273 YFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNL 319
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 16-99 3.18e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.48  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  16 IVTTAAPAIAADLGV--DSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGAR 93
Cdd:cd17315    15 VINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR 94


                  ....*.
gi 2495259862  94 VLQGVG 99
Cdd:cd17315    95 FLLGLG 100
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 14-172 3.63e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  14 ATIVTTAAPAIAAD-LGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGA 92
Cdd:cd06173   224 GGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAA 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  93 RVLQGVGGALMVPVGRLAVLRATPREGIIHAIAILVWPGLVAPVIAPFLGGLLTTVASWHWIFLINLPLGVVAFAIARRI 172
Cdd:cd06173   304 LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
PRK03699 PRK03699
putative transporter; Provisional
 24-207 6.21e-03

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 38.75  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  24 IAADLGVDSAAVSITVTafLLTVAVLIP--ASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGA 101
Cdd:PRK03699   33 IAEYFNLPVSSMSNTFT--FLNAGILISifLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVVSG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 102 LMVPVGRLAVLRATprEGIIHAIAILV------WPGLVAPVIAPFLgglLTTVASWHWIFLInlpLGVVAFAIARRIV-- 173
Cdd:PRK03699  111 ITMSIGTFLITHVY--EGKQRGSRLLFtdsffsMAGMIFPIIAAYL---LARSIEWYWVYAC---IGLVYVAIFILTLfs 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2495259862 174 -------PATAESAPPPLDVTGLVLVAVGLGALVGAAGLLT 207
Cdd:PRK03699  183 efpalgkHAPKADKPVAKEKWGIGVLFLAIAALLYILAQLT 223
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 22-101 6.28e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 38.77  E-value: 6.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  22 PAIAADLGVDSAAVSITVTAFLLTVAVL----IPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQG 97
Cdd:cd17388    23 PTLLREFVGDSADAATHYGVLLALYALMqfifAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAG 102


                  ....
gi 2495259862  98 VGGA 101
Cdd:cd17388   103 ITGA 106
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 25-168 6.56e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.68  E-value: 6.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  25 AADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQGVGGALMV 104
Cdd:cd17370   226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862 105 PVGRLAVLRATPRE------GIIHAIAILVWpgLVAPVIApflgGLLTTVASWHWIFLINLPLGVVAFAI 168
Cdd:cd17370   306 SIERAAVADLVPAElrgtayGLFNTVVGIGW--LLASLIA----GYLWDLISPSAAFLFSAVLALIALLL 369
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 17-118 7.81e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.37  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495259862  17 VTTAAPAIAADLGVDSAAVSITVTAFLLTVAVLIPASGWLSERFGVRRVFTSAIAVFTLASLLCALSPTLPLLVGARVLQ 96
Cdd:cd17475    15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94

                          90       100
                  ....*....|....*....|..
gi 2495259862  97 GVGGALMVPVGRLAVLRATPRE 118
Cdd:cd17475    95 GAGYGSVQPGGGRAIMRWFPPR 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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