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Conserved domains on  [gi|2415970352|ref|WP_269208291|]
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NAD(P)H-dependent oxidoreductase [Scardovia inopinata]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MdaB super family cl43659
Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction ...
 2-34 4.41e-08

Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only];


The actual alignment was detected with superfamily member COG2249:

Pssm-ID: 441850 [Multi-domain]  Cd Length: 190  Bit Score: 46.37  E-value: 4.41e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2415970352   2 NDPETKKYSDVITRSDILIFVYPIWWSGMPASL 34
Cdd:COG2249    58 LPIDVAAEQELLLWADHLVFQFPLWWYSMPALL 90
 
Name Accession Description Interval E-value
MdaB COG2249
Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction ...
 2-34 4.41e-08

Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only];


Pssm-ID: 441850 [Multi-domain]  Cd Length: 190  Bit Score: 46.37  E-value: 4.41e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2415970352   2 NDPETKKYSDVITRSDILIFVYPIWWSGMPASL 34
Cdd:COG2249    58 LPIDVAAEQELLLWADHLVFQFPLWWYSMPALL 90
PRK09739 PRK09739
NAD(P)H oxidoreductase;
2-34 3.65e-06

NAD(P)H oxidoreductase;


Pssm-ID: 236620 [Multi-domain]  Cd Length: 199  Bit Score: 41.23  E-value: 3.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2415970352   2 NDPEtKKYSDVITR-------SDILIFVYPIWWSGMPASL 34
Cdd:PRK09739   60 KNPD-KRYSPEVHQlyselleHDALVFVFPLWWYSFPAML 98
Flavodoxin_2 pfam02525
Flavodoxin-like fold; This family consists of a domain with a flavodoxin-like fold. The family ...
 13-34 2.18e-05

Flavodoxin-like fold; This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.


Pssm-ID: 426816 [Multi-domain]  Cd Length: 193  Bit Score: 38.85  E-value: 2.18e-05
                          10        20
                  ....*....|....*....|..
gi 2415970352  13 ITRSDILIFVYPIWWSGMPASL 34
Cdd:pfam02525  71 LLAADVIVFQFPLYWFSVPALL 92
 
Name Accession Description Interval E-value
MdaB COG2249
Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction ...
 2-34 4.41e-08

Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only];


Pssm-ID: 441850 [Multi-domain]  Cd Length: 190  Bit Score: 46.37  E-value: 4.41e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2415970352   2 NDPETKKYSDVITRSDILIFVYPIWWSGMPASL 34
Cdd:COG2249    58 LPIDVAAEQELLLWADHLVFQFPLWWYSMPALL 90
PRK09739 PRK09739
NAD(P)H oxidoreductase;
2-34 3.65e-06

NAD(P)H oxidoreductase;


Pssm-ID: 236620 [Multi-domain]  Cd Length: 199  Bit Score: 41.23  E-value: 3.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2415970352   2 NDPEtKKYSDVITR-------SDILIFVYPIWWSGMPASL 34
Cdd:PRK09739   60 KNPD-KRYSPEVHQlyselleHDALVFVFPLWWYSFPAML 98
Flavodoxin_2 pfam02525
Flavodoxin-like fold; This family consists of a domain with a flavodoxin-like fold. The family ...
 13-34 2.18e-05

Flavodoxin-like fold; This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.


Pssm-ID: 426816 [Multi-domain]  Cd Length: 193  Bit Score: 38.85  E-value: 2.18e-05
                          10        20
                  ....*....|....*....|..
gi 2415970352  13 ITRSDILIFVYPIWWSGMPASL 34
Cdd:pfam02525  71 LLAADVIVFQFPLYWFSVPALL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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