NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2350776959|ref|WP_266233118|]
View 

MULTISPECIES: carboxymuconolactone decarboxylase family protein [Paraburkholderia]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 11450212)

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4002925

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 40-177 1.02e-32

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


:

Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 113.82  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2350776959  40 SPIAFNAWAYLLGSLSKA--LDVKTRDSIGLAVSEVNGCNYCLTVHSFTAEHlAKLPAEEIILARKGHAA---DPKRDAA 114
Cdd:COG2128     2 SPELLKAFLALSGALMAKggLSPRERELVALRVSQINGCAYCLDAHTAIARK-AGLDEERIDALRAWRESplfDPRERAA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2350776959 115 VQFARKVIETRGKVGDADLNAVReAGYTDANVMEIVALVAMYSLTNFFNNVFDPDMDFPAVTP 177
Cdd:COG2128    81 LAFAEALTRTPGGVSDADVAALR-AGFSDAEIVELVLAIALFNMSNRLNNALGTPPDPPFAAL 142
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 40-177 1.02e-32

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 113.82  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2350776959  40 SPIAFNAWAYLLGSLSKA--LDVKTRDSIGLAVSEVNGCNYCLTVHSFTAEHlAKLPAEEIILARKGHAA---DPKRDAA 114
Cdd:COG2128     2 SPELLKAFLALSGALMAKggLSPRERELVALRVSQINGCAYCLDAHTAIARK-AGLDEERIDALRAWRESplfDPRERAA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2350776959 115 VQFARKVIETRGKVGDADLNAVReAGYTDANVMEIVALVAMYSLTNFFNNVFDPDMDFPAVTP 177
Cdd:COG2128    81 LAFAEALTRTPGGVSDADVAALR-AGFSDAEIVELVLAIALFNMSNRLNNALGTPPDPPFAAL 142
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 13-160 4.89e-23

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 90.16  E-value: 4.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2350776959  13 PAESKATLDGFAKNIGFTPNMMAAFAQSPIAFNAWA-------YLLGSLSKAldvkTRDSIGLAVSEVNGCNYCLTVHSF 85
Cdd:TIGR01926  12 TEEQKAYLAKIEEKTGFVPNVFRALAHDPEALRARTayfndlmLGEGGLSRA----ERELIAVVVSRANGCVYCAAVHGA 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2350776959  86 TAEHLAKLPAEEIILARKGHAAD--PKRDAAVQFARKVIETRGKVGDADLNAVREAGYTDANVMEIVALVAMYSLTN 160
Cdd:TIGR01926  88 ALRQLSGDPDLADAVAVNFRDADlsPRERAMLDFAVKLTATPAKVNEADFAALRAAGFSDLDILDLIHSVAFFNWAN 164
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 57-123 1.30e-04

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 38.83  E-value: 1.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2350776959  57 ALDVKTRDSIGLAVSEVNGCNYCLTVHSFTAEHlAKLPAEEIILARkGHAADPKRDAAVQFARKVIE 123
Cdd:pfam02627  19 GLDPKTRELIALAVSAANGCAYCLDAHTRAALK-AGVTEEEIAEVL-AWAAAYAGGPAARAALAAAE 83
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 40-177 1.02e-32

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 113.82  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2350776959  40 SPIAFNAWAYLLGSLSKA--LDVKTRDSIGLAVSEVNGCNYCLTVHSFTAEHlAKLPAEEIILARKGHAA---DPKRDAA 114
Cdd:COG2128     2 SPELLKAFLALSGALMAKggLSPRERELVALRVSQINGCAYCLDAHTAIARK-AGLDEERIDALRAWRESplfDPRERAA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2350776959 115 VQFARKVIETRGKVGDADLNAVReAGYTDANVMEIVALVAMYSLTNFFNNVFDPDMDFPAVTP 177
Cdd:COG2128    81 LAFAEALTRTPGGVSDADVAALR-AGFSDAEIVELVLAIALFNMSNRLNNALGTPPDPPFAAL 142
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 13-160 4.89e-23

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 90.16  E-value: 4.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2350776959  13 PAESKATLDGFAKNIGFTPNMMAAFAQSPIAFNAWA-------YLLGSLSKAldvkTRDSIGLAVSEVNGCNYCLTVHSF 85
Cdd:TIGR01926  12 TEEQKAYLAKIEEKTGFVPNVFRALAHDPEALRARTayfndlmLGEGGLSRA----ERELIAVVVSRANGCVYCAAVHGA 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2350776959  86 TAEHLAKLPAEEIILARKGHAAD--PKRDAAVQFARKVIETRGKVGDADLNAVREAGYTDANVMEIVALVAMYSLTN 160
Cdd:TIGR01926  88 ALRQLSGDPDLADAVAVNFRDADlsPRERAMLDFAVKLTATPAKVNEADFAALRAAGFSDLDILDLIHSVAFFNWAN 164
perox_Avi_7169 TIGR04030
alkylhydroperoxidase domain protein, Avi_7169 family; Members of this family represent a ...
 61-160 1.25e-07

alkylhydroperoxidase domain protein, Avi_7169 family; Members of this family represent a narrow clade that falls within a family of alkylhydroperoxidase-related proteins, fused to or adjacent to a sequence described by TIGR04029. These two partners occur almost always in the context of a putative FMN-dependent luciferase-like monooxygenase (LLM) (TIGR04027), and an ABC transporter in which TIGR04028 models the substrate-binding protein.


Pssm-ID: 188545  Cd Length: 185  Bit Score: 49.40  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2350776959  61 KTRDSIGLAVSEVNGCNYCLTVHSFTAEHLAKLPAEEIILARKGHAAD---PKRDAAVQFARKVIETRGKVGDADLNAVR 137
Cdd:TIGR04030  74 AERELAATVTSRYNGCIYCASVHARKASQLSKRRDDVQRLLDVGPGADlgsERWQAIIDAAAALSATPAAFNAAHVAALR 153

                          90       100
                  ....*....|....*....|...
gi 2350776959 138 EAGYTDANVMEIVALVAMYSLTN 160
Cdd:TIGR04030 154 AQGLDDLAIVDLIQSAAFFNWAN 176
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 57-106 1.65e-05

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 40.43  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2350776959  57 ALDVKTRDSIGLAVSEVNGCNYCLTVHSFTAeHLAKLPAEEIILARKGHA 106
Cdd:TIGR00778   2 ALDAATKELIAIAVSQINGCGYCLDAHTKLA-RKAGVTREELAEALAWAA 50
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 57-123 1.30e-04

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 38.83  E-value: 1.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2350776959  57 ALDVKTRDSIGLAVSEVNGCNYCLTVHSFTAEHlAKLPAEEIILARkGHAADPKRDAAVQFARKVIE 123
Cdd:pfam02627  19 GLDPKTRELIALAVSAANGCAYCLDAHTRAALK-AGVTEEEIAEVL-AWAAAYAGGPAARAALAAAE 83
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 29-83 1.34e-03

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 36.85  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2350776959  29 FTPNMMAAFAQ-SPIAFNAWAYLLGSLSK--ALDVKTRDSIGLAVSEVNGCNYCLTVH 83
Cdd:COG0599    10 YVPRALEALAEfAPEFAEAFEALFGDVWArgALDPKTRELITLAALAALGCEPCLKAH 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH