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Conserved domains on  [gi|2303410006|ref|WP_260146613|]
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GNAT family N-acetyltransferase [Streptomyces sp. 2132.2]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 36-139 7.72e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 7.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006  36 EVEPRSAEASALWVDRMGFFLTVDPEGCWVAVDDDEdeVVGFA---ISQNRGRLWYLATYGVLPGQQGRGVGKGLMDAAL 112
Cdd:pfam00583   8 LSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGE--LVGFAslsIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2303410006 113 ----AHGGDRQGLFISSVHPGATRRYRLAGF 139
Cdd:pfam00583  86 ewarERGCERIFLEVAADNLAAIALYEKLGF 116
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 36-139 7.72e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 7.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006  36 EVEPRSAEASALWVDRMGFFLTVDPEGCWVAVDDDEdeVVGFA---ISQNRGRLWYLATYGVLPGQQGRGVGKGLMDAAL 112
Cdd:pfam00583   8 LSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGE--LVGFAslsIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2303410006 113 ----AHGGDRQGLFISSVHPGATRRYRLAGF 139
Cdd:pfam00583  86 ewarERGCERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-114 1.71e-07

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 49.99  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006   1 MQIRLMRADDL-------HSAERASAATFleaerlnrravepEVEPRSAEasalwvDRMGFFLTVDPEG--CWVAVDDDE 71
Cdd:COG1247     2 MTIRPATPEDApaiaaiyNEAIAEGTATF-------------ETEPPSEE------EREAWFAAILAPGrpVLVAEEDGE 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2303410006  72 deVVGFA-ISQNRGRLWYLATY----GVLPGQQGRGVGKGLMDAALAH 114
Cdd:COG1247    63 --VVGFAsLGPFRPRPAYRGTAeesiYVDPDARGRGIGRALLEALIER 108
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 63-114 8.54e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.65  E-value: 8.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2303410006  63 CWVAVDDDEdeVVGFA---ISQNRGRLWYLATYGVLPGQQGRGVGKGLMDAALAH 114
Cdd:cd04301     1 FLVAEDDGE--IVGFAslsPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEE 53
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 36-139 7.72e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 7.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006  36 EVEPRSAEASALWVDRMGFFLTVDPEGCWVAVDDDEdeVVGFA---ISQNRGRLWYLATYGVLPGQQGRGVGKGLMDAAL 112
Cdd:pfam00583   8 LSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGE--LVGFAslsIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2303410006 113 ----AHGGDRQGLFISSVHPGATRRYRLAGF 139
Cdd:pfam00583  86 ewarERGCERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-114 1.71e-07

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 49.99  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006   1 MQIRLMRADDL-------HSAERASAATFleaerlnrravepEVEPRSAEasalwvDRMGFFLTVDPEG--CWVAVDDDE 71
Cdd:COG1247     2 MTIRPATPEDApaiaaiyNEAIAEGTATF-------------ETEPPSEE------EREAWFAAILAPGrpVLVAEEDGE 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2303410006  72 deVVGFA-ISQNRGRLWYLATY----GVLPGQQGRGVGKGLMDAALAH 114
Cdd:COG1247    63 --VVGFAsLGPFRPRPAYRGTAeesiYVDPDARGRGIGRALLEALIER 108
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
3-153 4.84e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 48.16  E-value: 4.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006   3 IRLMRADDLHsaerasaatflEAERLNRRAVEPEVEPRSAEAsalwvdrmgFFLTVDPEGCWVAVDDDEdeVVGFAISQ- 81
Cdd:COG3153     1 IRPATPEDAE-----------AIAALLRAAFGPGREAELVDR---------LREDPAAGLSLVAEDDGE--IVGHVALSp 58

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2303410006  82 ----NRGRLWYLATYGVLPGQQGRGVGKGLMDAALAHGGDR--QGLFISSvHPGATRRYRLAGFSLHSQVRMTGSVDR 153
Cdd:COG3153    59 vdidGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERgaRAVVLLG-DPSLLPFYERFGFRPAGELGLTLGPDE 135
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 63-114 8.54e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.65  E-value: 8.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2303410006  63 CWVAVDDDEdeVVGFA---ISQNRGRLWYLATYGVLPGQQGRGVGKGLMDAALAH 114
Cdd:cd04301     1 FLVAEDDGE--IVGFAslsPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEE 53
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 59-139 1.08e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 42.83  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006  59 DPEGCWVAVDDDEdeVVGFAISQNRGRLWYLATYG--VLPGQQGRGVGKGLMDAALAHGGDRQ-GLFISSVHPGATRRYR 135
Cdd:pfam13508   1 PGGRFFVAEDDGK--IVGFAALLPLDDEGALAELRlaVHPEYRGQGIGRALLEAAEAAAKEGGiKLLELETTNRAAAFYE 78


                  ....
gi 2303410006 136 LAGF 139
Cdd:pfam13508  79 KLGF 82
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 54-114 9.17e-05

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 41.52  E-value: 9.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2303410006  54 FFLTVDPEGCWVAVDDDEdeVVGF-AISQNRGRLWYLATYGVLPGQQGRGVGKGLMDAALAH 114
Cdd:COG1246    21 YALEEEIGEFWVAEEDGE--IVGCaALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAE 80
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-121 1.75e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 41.52  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006   1 MQIRLMRADDLhsaerASAATFLEAERLNRRAVEPevePRSAEASALWVDRMGFFLTVDPEGCWVAVDDDEDEVVGFAIS 80
Cdd:COG1670     8 LRLRPLRPEDA-----EALAELLNDPEVARYLPGP---PYSLEEARAWLERLLADWADGGALPFAIEDKEDGELIGVVGL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2303410006  81 QNRGRLWYLAT--YGVLPGQQGRGVGKGLMDAALAHGGDRQGL 121
Cdd:COG1670    80 YDIDRANRSAEigYWLAPAYWGKGYATEALRALLDYAFEELGL 122
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 64-139 2.68e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 39.95  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006  64 WVAvdDDEDEVVGFAISQNRGRLWYLAtygVLPGQQGRGVGKGLMDAALAHgGDRQGLFISSV----HPGATRRYRLAGF 139
Cdd:pfam13673  34 FVA--FEGGQIVGVIALRDRGHISLLF---VDPDYQGQGIGKALLEAVEDY-AEKDGIKLSELtvnaSPYAVPFYEKLGF 107
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 58-139 1.64e-03

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 38.11  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006  58 VDPEGCWVAVDDDeDEVVGFA----ISQNRGRLWYLAtygVLPGQQGRGVGKGLMDAAL----AHGGDRQGLFISSVHPG 129
Cdd:COG0454    30 SLAGAEFIAVDDK-GEPIGFAglrrLDDKVLELKRLY---VLPEYRGKGIGKALLEALLewarERGCTALELDTLDGNPA 105

                          90
                  ....*....|
gi 2303410006 130 ATRRYRLAGF 139
Cdd:COG0454   106 AIRFYERLGF 115
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 76-153 7.47e-03

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 35.02  E-value: 7.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2303410006  76 GFAI--SQNRGRLWYLATYGVLPGQQGRGVGKGLMDAAL----AHGGDRQGLFISSVHPGATRRYRLAGFSLHSQVRMTG 149
Cdd:COG0456     1 GFALlgLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALerarERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY 80


                  ....
gi 2303410006 150 SVDR 153
Cdd:COG0456    81 GDDA 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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