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Conserved domains on  [gi|2290299349|ref|WP_258569974|]
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MULTISPECIES: hypothetical protein [Burkholderia]

Protein Classification

tautomerase family protein( domain architecture ID 1755)

tautomerase family protein similar to Homo sapiens macrophage migration inhibitory factor and D-dopachrome decarboxylase-like protein

CATH:  3.30.429.10
Gene Ontology:  GO:0006725|GO:0016853
PubMed:  29184004|12051677|18695941
SCOP:  3001770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
4Oxalocrotonate_Tautomerase super family cl00235
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 12-40 1.24e-04

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


The actual alignment was detected with superfamily member PRK00745:

Pssm-ID: 444774  Cd Length: 62  Bit Score: 34.69  E-value: 1.24e-04
                         10        20
                 ....*....|....*....|....*....
gi 2290299349 12 CKRRSLYIALTDMKKDNRATAGKLSSDAR 40
Cdd:PRK00745  34 CPPESVDIIITDVKRENWATGGKLWSDPK 62
 
Name Accession Description Interval E-value
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 12-40 1.24e-04

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 34.69  E-value: 1.24e-04
                         10        20
                 ....*....|....*....|....*....
gi 2290299349 12 CKRRSLYIALTDMKKDNRATAGKLSSDAR 40
Cdd:PRK00745  34 CPPESVDIIITDVKRENWATGGKLWSDPK 62
 
Name Accession Description Interval E-value
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 12-40 1.24e-04

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 34.69  E-value: 1.24e-04
                         10        20
                 ....*....|....*....|....*....
gi 2290299349 12 CKRRSLYIALTDMKKDNRATAGKLSSDAR 40
Cdd:PRK00745  34 CPPESVDIIITDVKRENWATGGKLWSDPK 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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