MULTISPECIES: hypothetical protein [Campylobacter]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| PolY super family | cl28996 | Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
24-63 | 1.46e-08 | ||
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention. The actual alignment was detected with superfamily member cd01700: Pssm-ID: 452909 [Multi-domain] Cd Length: 344 Bit Score: 48.70 E-value: 1.46e-08
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| Name | Accession | Description | Interval | E-value | ||
| PolY_Pol_V_umuC | cd01700 | umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
24-63 | 1.46e-08 | ||
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage. Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 48.70 E-value: 1.46e-08
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| IMS | pfam00817 | impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
1-49 | 8.28e-07 | ||
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 42.95 E-value: 8.28e-07
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| PRK02406 | PRK02406 | DNA polymerase IV; Validated |
8-50 | 3.10e-06 | ||
DNA polymerase IV; Validated Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 42.03 E-value: 3.10e-06
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| DinP | COG0389 | Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
13-47 | 1.78e-04 | ||
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair]; Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 37.05 E-value: 1.78e-04
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| Name | Accession | Description | Interval | E-value | ||
| PolY_Pol_V_umuC | cd01700 | umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
24-63 | 1.46e-08 | ||
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage. Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 48.70 E-value: 1.46e-08
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| PolY_Pol_IV_kappa | cd03586 | DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
1-53 | 2.21e-07 | ||
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases. Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 45.20 E-value: 2.21e-07
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| IMS | pfam00817 | impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
1-49 | 8.28e-07 | ||
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 42.95 E-value: 8.28e-07
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| PRK02406 | PRK02406 | DNA polymerase IV; Validated |
8-50 | 3.10e-06 | ||
DNA polymerase IV; Validated Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 42.03 E-value: 3.10e-06
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| DinP | COG0389 | Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
13-47 | 1.78e-04 | ||
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair]; Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 37.05 E-value: 1.78e-04
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| PRK03103 | PRK03103 | DNA polymerase IV; Reviewed |
24-61 | 4.39e-04 | ||
DNA polymerase IV; Reviewed Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 36.13 E-value: 4.39e-04
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| PolY_Rev1 | cd01701 | DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
11-49 | 5.88e-04 | ||
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment. Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 35.75 E-value: 5.88e-04
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| Blast search parameters | ||||
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