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Conserved domains on  [gi|2232196789|ref|WP_248223627|]
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ADP-ribosylglycohydrolase family protein [Enterobacter quasiroggenkampii]

Protein Classification

ADP-ribosylglycohydrolase family protein( domain architecture ID 10509975)

ADP-ribosylglycohydrolase family protein similar to vertebrate [protein ADP-ribosylarginine] hydrolase, which catalyzes the reverse reaction of mono-ADP-ribosylation

CATH:  1.10.4080.10
EC:  3.2.2.-
Gene Ontology:  GO:0016799|GO:0046872

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ADPriboarghdlase super family cl46019
ADP-ribosylarginine hydrolase Tri1;
3-363 0e+00

ADP-ribosylarginine hydrolase Tri1;


The actual alignment was detected with superfamily member NF041672:

Pssm-ID: 469554  Cd Length: 360  Bit Score: 703.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789   3 IDLHANLNVLLKYVDIYRKYLPVSSLSVQQKMQYKYNDKLLESSfdCDAQKQWDLTPQCNISLAESRDRAVGALIGLAVG 82
Cdd:NF041672    2 IDLHSDDETLNDYAERYAHLLPPASRQLQQRMDYLSVDDAPWLS--GAELPAWLESRPCTLSEEQALDRAKGALVGLAVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789  83 DAVGTTLEFLPRDKAHVKDMIGGGPFRLRAGEWTDDTSMALCLAETLLEKGDADTICFRNKLLEWYRHGYNSSNGICFDI 162
Cdd:NF041672   80 DAVGTTLEFLPRDKAHVSDMVGGGPFRLKPGEWTDDTSMALCLAETYLEKGRLDITLFRNRLVRWYRNGENSSNGRCFDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 163 GNTTRFALEQYLTVGPGWSGNTAPETAGNASIIRQAPVSIFFRKSLSKAFYEAKKQSIATHGAAEAINSTQYLSYLLVHM 242
Cdd:NF041672  160 GNTTRYALEQYLKHGPSWFGNTEPNTAGNAAIIRLAPVAIFRRHSLLATWRDSQAQSRATHCAVESLDSCQLLGLILHYL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 243 INGSNKDFVFSPHVMPLQPRVMIINAGEYKQKTRDQIRSSGYVIDTLEAAMWSVWNTDNFRDAILLAANLADDADSVAAT 322
Cdd:NF041672  240 LNGADKEEAFSPHVMPLNPRVLIINAGEYKQKTRDQIRSSGYVIDTLEAALWAVWNTDNFRDAILLAANLADDADSVAAT 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2232196789 323 AGQIAGALYGYSGIPQDWKDKLVQHERIATMAGELFDRAPE 363
Cdd:NF041672  320 AGQIAGALYGYSGIPQEWVDKLAQHERIATLAEQLFDRAPE 360
 
Name Accession Description Interval E-value
ADPriboarghdlase NF041672
ADP-ribosylarginine hydrolase Tri1;
3-363 0e+00

ADP-ribosylarginine hydrolase Tri1;


Pssm-ID: 469554  Cd Length: 360  Bit Score: 703.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789   3 IDLHANLNVLLKYVDIYRKYLPVSSLSVQQKMQYKYNDKLLESSfdCDAQKQWDLTPQCNISLAESRDRAVGALIGLAVG 82
Cdd:NF041672    2 IDLHSDDETLNDYAERYAHLLPPASRQLQQRMDYLSVDDAPWLS--GAELPAWLESRPCTLSEEQALDRAKGALVGLAVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789  83 DAVGTTLEFLPRDKAHVKDMIGGGPFRLRAGEWTDDTSMALCLAETLLEKGDADTICFRNKLLEWYRHGYNSSNGICFDI 162
Cdd:NF041672   80 DAVGTTLEFLPRDKAHVSDMVGGGPFRLKPGEWTDDTSMALCLAETYLEKGRLDITLFRNRLVRWYRNGENSSNGRCFDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 163 GNTTRFALEQYLTVGPGWSGNTAPETAGNASIIRQAPVSIFFRKSLSKAFYEAKKQSIATHGAAEAINSTQYLSYLLVHM 242
Cdd:NF041672  160 GNTTRYALEQYLKHGPSWFGNTEPNTAGNAAIIRLAPVAIFRRHSLLATWRDSQAQSRATHCAVESLDSCQLLGLILHYL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 243 INGSNKDFVFSPHVMPLQPRVMIINAGEYKQKTRDQIRSSGYVIDTLEAAMWSVWNTDNFRDAILLAANLADDADSVAAT 322
Cdd:NF041672  240 LNGADKEEAFSPHVMPLNPRVLIINAGEYKQKTRDQIRSSGYVIDTLEAALWAVWNTDNFRDAILLAANLADDADSVAAT 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2232196789 323 AGQIAGALYGYSGIPQDWKDKLVQHERIATMAGELFDRAPE 363
Cdd:NF041672  320 AGQIAGALYGYSGIPQEWVDKLAQHERIATLAEQLFDRAPE 360
DraG COG1397
ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];
69-361 9.88e-88

ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441007  Cd Length: 256  Bit Score: 265.19  E-value: 9.88e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789  69 RDRAVGALIGLAVGDAVGTTLEFLPRDKAH-----VKDMIGGGPfrLRAGEWTDDTSMALCLAETLLEKGDADTICFRNK 143
Cdd:COG1397     2 LDRARGALLGLAIGDALGAPVEFYSREEIRarygpITDYVGGGN--LPPGEWTDDTQMALALAESLLEAGGFDPEDLARR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 144 LLEWYRHGYnssngiCFDIGNTTRFALEQYLTvgpGWSGNTAPETAGNASIIRQAPVSIFFRKSLSKAFYEAKKQSIATH 223
Cdd:COG1397    80 FLRWLRTGP------GRDIGPTTRRALRNLRR---GGAGESGEGSAGNGAAMRIAPLGLAYAGDPEEAAELARASAALTH 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 224 GAAEAINSTQYLSYLLVHMINGSNKDfvfsphvmplqprvmiinageykqktrdqirsSGYVIDTLEAAMWSVWNTDNFR 303
Cdd:COG1397   151 GHPRAIAGAVAYAAAVAAALRGADLE--------------------------------EGYVVETLPAALWALLRADDFE 198
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2232196789 304 DAILLAANLADDADSVAATAGQIAGALYGYSGIPQDWKDKLVQHERIATMAGELFDRA 361
Cdd:COG1397   199 EALLLAVNLGGDTDTTAAIAGALAGALYGLEAIPERWLEPLERRDRLEELAERLAALA 256
ADP_ribosyl_GH pfam03747
ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ...
74-339 1.45e-50

ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.


Pssm-ID: 461037 [Multi-domain]  Cd Length: 200  Bit Score: 167.75  E-value: 1.45e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789  74 GALIGLAVGDAVGTTLEFLPRDKAH------VKDMIGGGPFRLRAGEWTDDTSMALCLAETLLEKGDADticfrnkllew 147
Cdd:pfam03747   1 GALLGLAVGDALGAPVEFWSYDEIRreyggiGTPMPGGGHLGLPPGEWTDDTQMALALLESLLEAGGFD----------- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 148 yrhgynssngicfdignttrfaleqyltvgpgwsgntaPETAGNASIIRQAPVSIFFRKSLSKAFYEAKKQSIATHGAAE 227
Cdd:pfam03747  70 --------------------------------------PEDLARRLAMRIAPLGLLYPGDPEEAAELARESARLTHGHPR 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 228 AINSTQYLSYLLVHMINGSNKDFVFsphvmplqprvmiinageykqktrDQIRSSGYVIDTLEAAMWSVWN-TDNFRDAI 306
Cdd:pfam03747 112 AVAGAVAYAAAIAAALRGADLEEAL------------------------EAIGGGGYVVEALPAALYALLRaGDDFEEAL 167
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2232196789 307 LLAANLADDADSVAATAGQIAGALYGYSGIPQD 339
Cdd:pfam03747 168 LAAVNLGGDTDTTAAIAGALLGAYYGLEAIPEE 200
 
Name Accession Description Interval E-value
ADPriboarghdlase NF041672
ADP-ribosylarginine hydrolase Tri1;
3-363 0e+00

ADP-ribosylarginine hydrolase Tri1;


Pssm-ID: 469554  Cd Length: 360  Bit Score: 703.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789   3 IDLHANLNVLLKYVDIYRKYLPVSSLSVQQKMQYKYNDKLLESSfdCDAQKQWDLTPQCNISLAESRDRAVGALIGLAVG 82
Cdd:NF041672    2 IDLHSDDETLNDYAERYAHLLPPASRQLQQRMDYLSVDDAPWLS--GAELPAWLESRPCTLSEEQALDRAKGALVGLAVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789  83 DAVGTTLEFLPRDKAHVKDMIGGGPFRLRAGEWTDDTSMALCLAETLLEKGDADTICFRNKLLEWYRHGYNSSNGICFDI 162
Cdd:NF041672   80 DAVGTTLEFLPRDKAHVSDMVGGGPFRLKPGEWTDDTSMALCLAETYLEKGRLDITLFRNRLVRWYRNGENSSNGRCFDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 163 GNTTRFALEQYLTVGPGWSGNTAPETAGNASIIRQAPVSIFFRKSLSKAFYEAKKQSIATHGAAEAINSTQYLSYLLVHM 242
Cdd:NF041672  160 GNTTRYALEQYLKHGPSWFGNTEPNTAGNAAIIRLAPVAIFRRHSLLATWRDSQAQSRATHCAVESLDSCQLLGLILHYL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 243 INGSNKDFVFSPHVMPLQPRVMIINAGEYKQKTRDQIRSSGYVIDTLEAAMWSVWNTDNFRDAILLAANLADDADSVAAT 322
Cdd:NF041672  240 LNGADKEEAFSPHVMPLNPRVLIINAGEYKQKTRDQIRSSGYVIDTLEAALWAVWNTDNFRDAILLAANLADDADSVAAT 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2232196789 323 AGQIAGALYGYSGIPQDWKDKLVQHERIATMAGELFDRAPE 363
Cdd:NF041672  320 AGQIAGALYGYSGIPQEWVDKLAQHERIATLAEQLFDRAPE 360
DraG COG1397
ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];
69-361 9.88e-88

ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441007  Cd Length: 256  Bit Score: 265.19  E-value: 9.88e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789  69 RDRAVGALIGLAVGDAVGTTLEFLPRDKAH-----VKDMIGGGPfrLRAGEWTDDTSMALCLAETLLEKGDADTICFRNK 143
Cdd:COG1397     2 LDRARGALLGLAIGDALGAPVEFYSREEIRarygpITDYVGGGN--LPPGEWTDDTQMALALAESLLEAGGFDPEDLARR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 144 LLEWYRHGYnssngiCFDIGNTTRFALEQYLTvgpGWSGNTAPETAGNASIIRQAPVSIFFRKSLSKAFYEAKKQSIATH 223
Cdd:COG1397    80 FLRWLRTGP------GRDIGPTTRRALRNLRR---GGAGESGEGSAGNGAAMRIAPLGLAYAGDPEEAAELARASAALTH 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 224 GAAEAINSTQYLSYLLVHMINGSNKDfvfsphvmplqprvmiinageykqktrdqirsSGYVIDTLEAAMWSVWNTDNFR 303
Cdd:COG1397   151 GHPRAIAGAVAYAAAVAAALRGADLE--------------------------------EGYVVETLPAALWALLRADDFE 198
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2232196789 304 DAILLAANLADDADSVAATAGQIAGALYGYSGIPQDWKDKLVQHERIATMAGELFDRA 361
Cdd:COG1397   199 EALLLAVNLGGDTDTTAAIAGALAGALYGLEAIPERWLEPLERRDRLEELAERLAALA 256
ADP_ribosyl_GH pfam03747
ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ...
74-339 1.45e-50

ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.


Pssm-ID: 461037 [Multi-domain]  Cd Length: 200  Bit Score: 167.75  E-value: 1.45e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789  74 GALIGLAVGDAVGTTLEFLPRDKAH------VKDMIGGGPFRLRAGEWTDDTSMALCLAETLLEKGDADticfrnkllew 147
Cdd:pfam03747   1 GALLGLAVGDALGAPVEFWSYDEIRreyggiGTPMPGGGHLGLPPGEWTDDTQMALALLESLLEAGGFD----------- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 148 yrhgynssngicfdignttrfaleqyltvgpgwsgntaPETAGNASIIRQAPVSIFFRKSLSKAFYEAKKQSIATHGAAE 227
Cdd:pfam03747  70 --------------------------------------PEDLARRLAMRIAPLGLLYPGDPEEAAELARESARLTHGHPR 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2232196789 228 AINSTQYLSYLLVHMINGSNKDFVFsphvmplqprvmiinageykqktrDQIRSSGYVIDTLEAAMWSVWN-TDNFRDAI 306
Cdd:pfam03747 112 AVAGAVAYAAAIAAALRGADLEEAL------------------------EAIGGGGYVVEALPAALYALLRaGDDFEEAL 167
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2232196789 307 LLAANLADDADSVAATAGQIAGALYGYSGIPQD 339
Cdd:pfam03747 168 LAAVNLGGDTDTTAAIAGALLGAYYGLEAIPEE 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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