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Conserved domains on  [gi|2216749913|ref|WP_243441600|]
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alpha/beta hydrolase [Schaalia georgiae]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11455169)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  37582413|12369917|19508187

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
4-231 1.07e-16

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


:

Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 76.58  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   4 VTIETPRGVVLSGTMIDPVDSRDAAVLFSHTFLADRRSsafFDDIARAFRGAGYATLAFDYSGHGRSGDE---IITLSAM 80
Cdd:COG2267     6 VTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGR---YAELAEALAAAGYAVLAFDLRGHGRSDGPrghVDSFDDY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  81 IEDLRAASGWLADHGHPRQIVHAHEFGATVALE--ARPPSAVT-YILSSPALgplsydwttifsevqLSDlehygtttiP 157
Cdd:COG2267    83 VDDLRAALDALRARPGLPVVLLGHSMGGLIALLyaARYPDRVAgLVLLAPAY---------------RAD---------P 138

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2216749913 158 DDSPSVRrhftiskqTLADLSMADAkklLTGLEVPTLITHDAVDeETGLLDLTRAAFPLLPDGSRVEITSDDGH 231
Cdd:COG2267   139 LLGPSAR--------WLRALRLAEA---LARIDVPVLVLHGGAD-RVVPPEAARRLAARLSPDVELVLLPGARH 200
 
Name Accession Description Interval E-value
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
4-231 1.07e-16

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 76.58  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   4 VTIETPRGVVLSGTMIDPVDSRDAAVLFSHTFLADRRSsafFDDIARAFRGAGYATLAFDYSGHGRSGDE---IITLSAM 80
Cdd:COG2267     6 VTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGR---YAELAEALAAAGYAVLAFDLRGHGRSDGPrghVDSFDDY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  81 IEDLRAASGWLADHGHPRQIVHAHEFGATVALE--ARPPSAVT-YILSSPALgplsydwttifsevqLSDlehygtttiP 157
Cdd:COG2267    83 VDDLRAALDALRARPGLPVVLLGHSMGGLIALLyaARYPDRVAgLVLLAPAY---------------RAD---------P 138

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2216749913 158 DDSPSVRrhftiskqTLADLSMADAkklLTGLEVPTLITHDAVDeETGLLDLTRAAFPLLPDGSRVEITSDDGH 231
Cdd:COG2267   139 LLGPSAR--------WLRALRLAEA---LARIDVPVLVLHGGAD-RVVPPEAARRLAARLSPDVELVLLPGARH 200
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-197 7.49e-12

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 63.39  E-value: 7.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  23 DSRDAAVLFSHTFlADrrSSAFFDDIARAFRGAGYATLAFDYSGHGRSGDE---IITLSAMIEDLRAASGWL-ADHGHPR 98
Cdd:pfam12146   1 GEPRAVVVLVHGL-GE--HSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKrghVPSFDDYVDDLDTFVDKIrEEHPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  99 QIVHAHEFGATVALEA---RPPSAVTYILSSPALGPLSYD-------WTTIFSEV--QLSDLEHYGTTTIPDDSPSVRR- 165
Cdd:pfam12146  78 LFLLGHSMGGLIAALYalrYPDKVDGLILSAPALKIKPYLappilklLAKLLGKLfpRLRVPNNLLPDSLSRDPEVVAAy 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2216749913 166 ------HFTISKQTLADL--SMADAKKLLTGLEVPTLITH 197
Cdd:pfam12146 158 aadplvHGGISARTLYELldAGERLLRRAAAITVPLLLLH 197
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 21-114 6.41e-04

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 40.19  E-value: 6.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  21 PVDSRDAAVLFSHTFLAD----RRSSAFfddIARAFRGAGYATLAFDYSGHGRS-GDEI-ITLSAMIEDLRAASGWLADH 94
Cdd:TIGR03101  20 VAVGPRGVVIYLPPFAEEmnksRRMVAL---QARAFAAGGFGVLQIDLYGCGDSaGDFAaARWDVWKEDVAAAYRWLIEQ 96

                          90       100
                  ....*....|....*....|
gi 2216749913  95 GHPRQIVHAHEFGATVALEA 114
Cdd:TIGR03101  97 GHPPVTLWGLRLGALLALDA 116
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 8-131 5.88e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 37.62  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   8 TPRGVVLSGTMI---DPVDSRDAAVLFSHTFLADRRSSAF-FDDIArafrgAGYATLAFDYSGHGRSGDEIITLSamIED 83
Cdd:PRK14875  110 APRKARIGGRTVrylRLGEGDGTPVVLIHGFGGDLNNWLFnHAALA-----AGRPVIALDLPGHGASSKAVGAGS--LDE 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2216749913  84 LRAA-SGWLADHGHPRQIVHAHEFGATVALE--ARPPSAVTYI-LSSPA-LGP 131
Cdd:PRK14875  183 LAAAvLAFLDALGIERAHLVGHSMGGAVALRlaARAPQRVASLtLIAPAgLGP 235
 
Name Accession Description Interval E-value
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
4-231 1.07e-16

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 76.58  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   4 VTIETPRGVVLSGTMIDPVDSRDAAVLFSHTFLADRRSsafFDDIARAFRGAGYATLAFDYSGHGRSGDE---IITLSAM 80
Cdd:COG2267     6 VTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGR---YAELAEALAAAGYAVLAFDLRGHGRSDGPrghVDSFDDY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  81 IEDLRAASGWLADHGHPRQIVHAHEFGATVALE--ARPPSAVT-YILSSPALgplsydwttifsevqLSDlehygtttiP 157
Cdd:COG2267    83 VDDLRAALDALRARPGLPVVLLGHSMGGLIALLyaARYPDRVAgLVLLAPAY---------------RAD---------P 138

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2216749913 158 DDSPSVRrhftiskqTLADLSMADAkklLTGLEVPTLITHDAVDeETGLLDLTRAAFPLLPDGSRVEITSDDGH 231
Cdd:COG2267   139 LLGPSAR--------WLRALRLAEA---LARIDVPVLVLHGGAD-RVVPPEAARRLAARLSPDVELVLLPGARH 200
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 1-127 3.05e-13

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 67.63  E-value: 3.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   1 MSDVTIETPRGVVLSGTMI--DPVDSRDAAVLFSHTFLADRRSSAffdDIARAFRGAGYATLAFDYSGHGRSGDEIITL- 77
Cdd:COG1073    10 KEDVTFKSRDGIKLAGDLYlpAGASKKYPAVVVAHGNGGVKEQRA---LYAQRLAELGFNVLAFDYRGYGESEGEPREEg 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2216749913  78 SAMIEDLRAASGWLADH--GHPRQI-VHAHEFGATVALEA----RPPSAVtyILSSP 127
Cdd:COG1073    87 SPERRDARAAVDYLRTLpgVDPERIgLLGISLGGGYALNAaatdPRVKAV--ILDSP 141
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
5-202 5.71e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 63.50  E-value: 5.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   5 TIETPRGVVLSGTMIDPVDSRDA-AVLFSHTFLADRrsSAFFDDIARAFRGAGYATLAFDYSGHGRSGDEIitLSAMIED 83
Cdd:COG1506     1 TFKSADGTTLPGWLYLPADGKKYpVVVYVHGGPGSR--DDSFLPLAQALASRGYAVLAPDYRGYGESAGDW--GGDEVDD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  84 LRAASGWLADHGH--PRQI-VHAHEFGATVALEA---RPPSAVTYILSSPAlgplsYDWTTIFSEVQLSDLEHYGTttiP 157
Cdd:COG1506    77 VLAAIDYLAARPYvdPDRIgIYGHSYGGYMALLAaarHPDRFKAAVALAGV-----SDLRSYYGTTREYTERLMGG---P 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2216749913 158 DDSPsvrrhftiskQTLADLS-MADAKKlltgLEVPTLITHDAVDE 202
Cdd:COG1506   149 WEDP----------EAYAARSpLAYADK----LKTPLLLIHGEADD 180
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-197 7.49e-12

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 63.39  E-value: 7.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  23 DSRDAAVLFSHTFlADrrSSAFFDDIARAFRGAGYATLAFDYSGHGRSGDE---IITLSAMIEDLRAASGWL-ADHGHPR 98
Cdd:pfam12146   1 GEPRAVVVLVHGL-GE--HSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKrghVPSFDDYVDDLDTFVDKIrEEHPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  99 QIVHAHEFGATVALEA---RPPSAVTYILSSPALGPLSYD-------WTTIFSEV--QLSDLEHYGTTTIPDDSPSVRR- 165
Cdd:pfam12146  78 LFLLGHSMGGLIAALYalrYPDKVDGLILSAPALKIKPYLappilklLAKLLGKLfpRLRVPNNLLPDSLSRDPEVVAAy 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2216749913 166 ------HFTISKQTLADL--SMADAKKLLTGLEVPTLITH 197
Cdd:pfam12146 158 aadplvHGGISARTLYELldAGERLLRRAAAITVPLLLLH 197
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
28-202 1.10e-09

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 57.26  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  28 AVLFSHTFLADRRSsafFDDIARAFRGAGYATLAFDYSGHGRSGDEIITLSA--MIEDLRAASGWLADhGHPRQIVHAHE 105
Cdd:COG1647    17 GVLLLHGFTGSPAE---MRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWedWLEDVEEAYEILKA-GYDKVIVIGLS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913 106 FGATVALEA----RPPSAVtyILSSPALGPlsYDWTTIFSEV--QLSDLEHYGTTTIPDDSPSVRRHFTISKQTLADLS- 178
Cdd:COG1647    93 MGGLLALLLaaryPDVAGL--VLLSPALKI--DDPSAPLLPLlkYLARSLRGIGSDIEDPEVAEYAYDRTPLRALAELQr 168

                         170       180
                  ....*....|....*....|....*
gi 2216749913 179 -MADAKKLLTGLEVPTLITHDAVDE 202
Cdd:COG1647   169 lIREVRRDLPKITAPTLIIQSRKDE 193
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
3-108 4.48e-07

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 49.88  E-value: 4.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   3 DVTIETPRGVVLSGTMIDPVDSRDAAVLFSHTfLADRRSsaFFDDIARAFRGAGYATLAFDYSGHGRSGDEII-----TL 77
Cdd:COG4757     9 SVTITAADGYPLAARLFPPAGPPRAVVLINPA-TGVPQR--FYRPFARYLAERGFAVLTYDYRGIGLSRPGSLrgfdaGY 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2216749913  78 SAMIE-DLRAASGWLADH--GHPRQIVhAHEFGA 108
Cdd:COG4757    86 RDWGElDLPAVLDALRARfpGLPLLLV-GHSLGG 118
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
3-114 1.08e-06

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 48.42  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   3 DVTIETPRGVVLSGTMIDPVDS-RDAAVLFSHTFLAdrrSSAFFDDIARAFRGAGYATLAFD-YSGHGRSGDE------- 73
Cdd:COG0412     5 TVTIPTPDGVTLPGYLARPAGGgPRPGVVVLHEIFG---LNPHIRDVARRLAAAGYVVLAPDlYGRGGPGDDPdearalm 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2216749913  74 -IITLSAMIEDLRAASGWLADHGH--PRQIVHA-HEFGATVALEA 114
Cdd:COG0412    82 gALDPELLAADLRAALDWLKAQPEvdAGRVGVVgFCFGGGLALLA 126
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-231 1.23e-06

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 48.07  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   8 TPRGVVLSGTMIDPVDSRDAA--VLFSHTFLADRRSsafFDDIARAFRgAGYATLAFDYSGHGRSG--DEIITLSAMIED 83
Cdd:COG0596     3 TPRFVTVDGVRLHYREAGPDGppVVLLHGLPGSSYE---WRPLIPALA-AGYRVIAPDLRGHGRSDkpAGGYTLDDLADD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  84 LRAasgwLADH-GHPRQIVHAHEFGATVALE--ARPPSAVTyilsspALgplsydwtTIFSEVQLSDLEHYgtTTIPDDS 160
Cdd:COG0596    79 LAA----LLDAlGLERVVLVGHSMGGMVALElaARHPERVA------GL--------VLVDEVLAALAEPL--RRPGLAP 138

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2216749913 161 PSVRRhftiskqTLADLSMADAKKLLTGLEVPTLITHDAVDEETGlLDLTRAAFPLLPDGSRVEItSDDGH 231
Cdd:COG0596   139 EALAA-------LLRALARTDLRERLARITVPTLVIWGEKDPIVP-PALARRLAELLPNAELVVL-PGAGH 200
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
48-135 1.91e-05

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 44.38  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  48 IARAFRGAGYATLAFDYSGHGRSG---DEIITLsamIEDLRAASGWLADHGHPRQIVHAHEFGATVALEA--RPPSAVTY 122
Cdd:COG2945    47 LARALVAAGFAVLRFNFRGVGRSEgefDEGRGE---LDDAAAALDWLRAQNPLPLWLAGFSFGAYVALQLamRLPEVEGL 123

                          90
                  ....*....|...
gi 2216749913 123 ILSSPALGPLSYD 135
Cdd:COG2945   124 ILVAPPVNRYDFS 136
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 21-114 6.41e-04

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 40.19  E-value: 6.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  21 PVDSRDAAVLFSHTFLAD----RRSSAFfddIARAFRGAGYATLAFDYSGHGRS-GDEI-ITLSAMIEDLRAASGWLADH 94
Cdd:TIGR03101  20 VAVGPRGVVIYLPPFAEEmnksRRMVAL---QARAFAAGGFGVLQIDLYGCGDSaGDFAaARWDVWKEDVAAAYRWLIEQ 96

                          90       100
                  ....*....|....*....|
gi 2216749913  95 GHPRQIVHAHEFGATVALEA 114
Cdd:TIGR03101  97 GHPPVTLWGLRLGALLALDA 116
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 28-179 1.23e-03

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.41  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  28 AVLFSHTFLAdrrSSAFFDDIARAFRGAGYATLAFDYSGHGRSGD-------EIITLSAMIEDLRAAsgwladHGHPRQI 100
Cdd:pfam00561   2 PVLLLHGLPG---SSDLWRKLAPALARDGFRVIALDLRGFGKSSRpkaqddyRTDDLAEDLEYILEA------LGLEKVN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913 101 VHAHEFGATVALE--ARPPSAV-TYILSSPALGPLSYDwttIFSEVQLSDLEHYGTTTIPDDSPSVRRHFTISKQTLADL 177
Cdd:pfam00561  73 LVGHSMGGLIALAyaAKYPDRVkALVLLGALDPPHELD---EADRFILALFPGFFDGFVADFAPNPLGRLVAKLLALLLL 149


                  ..
gi 2216749913 178 SM 179
Cdd:pfam00561 150 RL 151
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 50-132 3.61e-03

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 37.84  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913  50 RAFRGAGYATLAFDYSGHGRSGDEIITLSAmIEDLRAASGWLADHGHPrqIVHAHEFGATVALEARPPSAVTYILSSPAL 129
Cdd:pfam12697  15 AALLAAGVAVLAPDLPGHGSSSPPPLDLAD-LADLAALLDELGAARPV--VLVGHSLGGAVALAAAAAALVVGVLVAPLA 91


                  ...
gi 2216749913 130 GPL 132
Cdd:pfam12697  92 APP 94
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 8-131 5.88e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 37.62  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216749913   8 TPRGVVLSGTMI---DPVDSRDAAVLFSHTFLADRRSSAF-FDDIArafrgAGYATLAFDYSGHGRSGDEIITLSamIED 83
Cdd:PRK14875  110 APRKARIGGRTVrylRLGEGDGTPVVLIHGFGGDLNNWLFnHAALA-----AGRPVIALDLPGHGASSKAVGAGS--LDE 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2216749913  84 LRAA-SGWLADHGHPRQIVHAHEFGATVALE--ARPPSAVTYI-LSSPA-LGP 131
Cdd:PRK14875  183 LAAAvLAFLDALGIERAHLVGHSMGGAVALRlaARAPQRVASLtLIAPAgLGP 235
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 29-89 5.97e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 35.58  E-value: 5.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2216749913  29 VLFSHTFLADRRSsafFDDIARAFRGAGYATLAFDYSGHGRSGDEIIT-LSAMIEDLRAASG 89
Cdd:COG1075     8 VVLVHGLGGSAAS---WAPLAPRLRAAGYPVYALNYPSTNGSIEDSAEqLAAFVDAVLAATG 66
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 10-70 8.19e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 37.04  E-value: 8.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2216749913  10 RGV-VLSGTMIDPVDSRDAAVLFSH------TFladrrssaFFDDIARAFRGAGYATLAFDYSGHGRS 70
Cdd:PLN02385   70 RGVeIFSKSWLPENSRPKAAVCFCHgygdtcTF--------FFEGIARKIASSGYGVFAMDYPGFGLS 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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