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Conserved domains on  [gi|2189112175|ref|WP_237141628|]
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Na+ dependent nucleoside transporter N-terminal domain-containing protein [Selenomonas sp. oral taxon 126]

Protein Classification

NupC/NupG family nucleoside CNT transporter( domain architecture ID 1750049)

NupC/NupG family nucleoside CNT transporter similar to Bacillus subtilis purine nucleoside transport protein NupG, which is involved in the uptake of the purine ribonucleosides inosine and guanosine

Gene Ontology:  GO:0005337|GO:1901642|GO:0005886
TCDB:  2.A.41

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NupC super family cl40784
Nucleoside permease NupC [Nucleotide transport and metabolism];
1-118 2.07e-31

Nucleoside permease NupC [Nucleotide transport and metabolism];


The actual alignment was detected with superfamily member COG1972:

Pssm-ID: 441575 [Multi-domain]  Cd Length: 406  Bit Score: 114.42  E-value: 2.07e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189112175   1 MFFFVNLLGLVVFLGIGVLASRNRKEIQWRSVASLLALNLMLAWFLTSFEIGREMITAAAGGFTELINISYVGIAFVFPD 80
Cdd:COG1972     1 MNILIGLLGIAVLLGIAWLFSENRKAINWRTVGIGLALQLLLAFLVLKVPAGRAAFEALSDGVNKLLSYANEGTAFVFGG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2189112175  81 WVNVPQ---MNFFAAALLPILFVVPLFDILTYFGILPFVIR 118
Cdd:COG1972    81 LAGPGLpggFVFAFQVLPPIIFFSALISILYYLGILQFIVR 121
 
Name Accession Description Interval E-value
NupC COG1972
Nucleoside permease NupC [Nucleotide transport and metabolism];
1-118 2.07e-31

Nucleoside permease NupC [Nucleotide transport and metabolism];


Pssm-ID: 441575 [Multi-domain]  Cd Length: 406  Bit Score: 114.42  E-value: 2.07e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189112175   1 MFFFVNLLGLVVFLGIGVLASRNRKEIQWRSVASLLALNLMLAWFLTSFEIGREMITAAAGGFTELINISYVGIAFVFPD 80
Cdd:COG1972     1 MNILIGLLGIAVLLGIAWLFSENRKAINWRTVGIGLALQLLLAFLVLKVPAGRAAFEALSDGVNKLLSYANEGTAFVFGG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2189112175  81 WVNVPQ---MNFFAAALLPILFVVPLFDILTYFGILPFVIR 118
Cdd:COG1972    81 LAGPGLpggFVFAFQVLPPIIFFSALISILYYLGILQFIVR 121
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
 5-118 5.54e-22

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 88.90  E-value: 5.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189112175   5 VNLLGLVVFLGIGVLASRNRKEIQWRSVASLLALNLMLAWFLTSFEIGREMITAAAGGFTELINISYVGIAFVFPDWVNV 84
Cdd:TIGR00804   2 ISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLVQ 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2189112175  85 PQMNFFAAALLPILFVVPLFDILTYFGILPFVIR 118
Cdd:TIGR00804  82 DLFVFAFQVLPIIIFFSALISILYYLGIMQWVIR 115
Nucleos_tra2_N pfam01773
Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport ...
 9-81 3.22e-15

Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the N terminus of this family


Pssm-ID: 460319 [Multi-domain]  Cd Length: 73  Bit Score: 64.70  E-value: 3.22e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2189112175   9 GLVVFLGIGVLASRNRKEIQWRSVASLLALNLMLAWFLTSFEIGREMITAAAGGFTELINISYVGIAFVFPDW 81
Cdd:pfam01773   1 GLLVLLGIAWLFSKNRKAINWRTVIGGLALQFLLALFVLRTPAGRDAFKWISDGVTALLGYADAGTAFVFGGL 73
 
Name Accession Description Interval E-value
NupC COG1972
Nucleoside permease NupC [Nucleotide transport and metabolism];
1-118 2.07e-31

Nucleoside permease NupC [Nucleotide transport and metabolism];


Pssm-ID: 441575 [Multi-domain]  Cd Length: 406  Bit Score: 114.42  E-value: 2.07e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189112175   1 MFFFVNLLGLVVFLGIGVLASRNRKEIQWRSVASLLALNLMLAWFLTSFEIGREMITAAAGGFTELINISYVGIAFVFPD 80
Cdd:COG1972     1 MNILIGLLGIAVLLGIAWLFSENRKAINWRTVGIGLALQLLLAFLVLKVPAGRAAFEALSDGVNKLLSYANEGTAFVFGG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2189112175  81 WVNVPQ---MNFFAAALLPILFVVPLFDILTYFGILPFVIR 118
Cdd:COG1972    81 LAGPGLpggFVFAFQVLPPIIFFSALISILYYLGILQFIVR 121
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
 5-118 5.54e-22

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 88.90  E-value: 5.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189112175   5 VNLLGLVVFLGIGVLASRNRKEIQWRSVASLLALNLMLAWFLTSFEIGREMITAAAGGFTELINISYVGIAFVFPDWVNV 84
Cdd:TIGR00804   2 ISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLVQ 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2189112175  85 PQMNFFAAALLPILFVVPLFDILTYFGILPFVIR 118
Cdd:TIGR00804  82 DLFVFAFQVLPIIIFFSALISILYYLGIMQWVIR 115
Nucleos_tra2_N pfam01773
Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport ...
 9-81 3.22e-15

Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the N terminus of this family


Pssm-ID: 460319 [Multi-domain]  Cd Length: 73  Bit Score: 64.70  E-value: 3.22e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2189112175   9 GLVVFLGIGVLASRNRKEIQWRSVASLLALNLMLAWFLTSFEIGREMITAAAGGFTELINISYVGIAFVFPDW 81
Cdd:pfam01773   1 GLLVLLGIAWLFSKNRKAINWRTVIGGLALQFLLALFVLRTPAGRDAFKWISDGVTALLGYADAGTAFVFGGL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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