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Conserved domains on  [gi|2176060514|ref|WP_234003038|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Erythrobacteraceae]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11441299)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to sulfide:quinone oxidoreductase which catalyzes the oxidation of hydrogen sulfide using quinone as the electron acceptor

EC:  1.6.-.-
Gene Ontology:  GO:0003954|GO:0006116
PubMed:  15590775|28181562

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
42-408 2.36e-143

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


:

Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 414.92  E-value: 2.36e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  42 AEVTLIDQTNHHLFQPLLYQVATAALSPSDIATATRVLMRGgSNLSVLMAEVTGVDIRARSVLLRNGHRLPYDYLVLATG 121
Cdd:COG1252    28 AEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRR-AGVRFIQGEVTGIDPEARTVTLADGRTLSYDYLVIATG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 122 SASSFFGQDNWREHTLVLKTIEDALAIRARLLEAFERAEQstddveiRRLLTFAIVGGGPTGVELAGTISELARATLArd 201
Cdd:COG1252   107 SVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER-------RRLLTIVVVGGGPTGVELAGELAELLRKLLR-- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 202 FSRIDPRDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAIDPTGVVLGS-ERIDTGAVLWCAGTEARP 280
Cdd:COG1252   178 YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDgEEIPADTVIWAAGVKAPP 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 281 AAEWLGIDGVRNGAVTVRSDCSVPGHPNIFAIGDVASFETDGGKRLPALAPVAKQQGTYVGKLLAARIAGrREPVAFRYR 360
Cdd:COG1252   258 LLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLAKNIAALLRG-KPLKPFRYR 336

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2176060514 361 DYGTMAVIGRSRAAAQFGRLRLTGFLAWLVWSLIHLMLLVDFRSRLVV 408
Cdd:COG1252   337 DKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLPGFRGRLRV 384
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
42-408 2.36e-143

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 414.92  E-value: 2.36e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  42 AEVTLIDQTNHHLFQPLLYQVATAALSPSDIATATRVLMRGgSNLSVLMAEVTGVDIRARSVLLRNGHRLPYDYLVLATG 121
Cdd:COG1252    28 AEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRR-AGVRFIQGEVTGIDPEARTVTLADGRTLSYDYLVIATG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 122 SASSFFGQDNWREHTLVLKTIEDALAIRARLLEAFERAEQstddveiRRLLTFAIVGGGPTGVELAGTISELARATLArd 201
Cdd:COG1252   107 SVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER-------RRLLTIVVVGGGPTGVELAGELAELLRKLLR-- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 202 FSRIDPRDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAIDPTGVVLGS-ERIDTGAVLWCAGTEARP 280
Cdd:COG1252   178 YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDgEEIPADTVIWAAGVKAPP 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 281 AAEWLGIDGVRNGAVTVRSDCSVPGHPNIFAIGDVASFETDGGKRLPALAPVAKQQGTYVGKLLAARIAGrREPVAFRYR 360
Cdd:COG1252   258 LLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLAKNIAALLRG-KPLKPFRYR 336

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2176060514 361 DYGTMAVIGRSRAAAQFGRLRLTGFLAWLVWSLIHLMLLVDFRSRLVV 408
Cdd:COG1252   337 DKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLPGFRGRLRV 384
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 18-421 4.26e-79

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 251.61  E-value: 4.26e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  18 RPRVVIVGAGFGGMAAARALRGHAAEVTLIDQTNHHLFQPLLYQVATAALSPSDIATATRVLMRGGSNlSVLMAEVTGVD 97
Cdd:PTZ00318   10 KPNVVVLGTGWAGAYFVRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKLPN-RYLRAVVYDVD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  98 IRARSVLLRNGHR----------LPYDYLVLATGSASSFFGQDNWREHTLVLKTIEDALAIRARLLEAFERAEQSTDDVE 167
Cdd:PTZ00318   89 FEEKRVKCGVVSKsnnanvntfsVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPTTSVE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 168 IR-RLLTFAIVGGGPTGVELAGTISELARATLARDFSRIDPrDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRI 246
Cdd:PTZ00318  169 ERkRLLHFVVVGGGPTGVEFAAELADFFRDDVRNLNPELVE-ECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIRT 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 247 GTTVEAIDPTGVVLGS-ERIDTGAVLWCAGTEARPAAEWLGIDGVRNGAVTVRSDCSVPGHPNIFAIGDVASFETdggKR 325
Cdd:PTZ00318  248 KTAVKEVLDKEVVLKDgEVIPTGLVVWSTGVGPGPLTKQLKVDKTSRGRISVDDHLRVKPIPNVFALGDCAANEE---RP 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 326 LPALAPVAKQQGTYVGKLLAARIAGRREPVAFRYRDYGTMAVIGRSRAAAQFGRLRLTGFLAWLVWSLIHLMLLVDFRSR 405
Cdd:PTZ00318  325 LPTLAQVASQQGVYLAKEFNNELKGKPMSKPFVYRSLGSLAYLGNYSAIVQLGAFDLSGFKALLFWRSAYLTILGSWRSK 404

                         410
                  ....*....|....*..
gi 2176060514 406 LVVYVNWA-WAWFtyGR 421
Cdd:PTZ00318  405 LYVLVNWAgTAIF--GR 419
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 19-337 2.50e-37

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 138.22  E-value: 2.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  19 PRVVIVGAGFGGMAAARALRGHAAEVTLI-DQTNHHLFQPLLYQVATAALSPSDIATATRVLM--------RGGSNLSVL 89
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASLWADLYkrkeevvkKLNNGIEVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  90 MA-EVTGVDIRARSVLLR-----NGHRLPYDYLVLATGSASSFFGQDNWREH-TLVLKTIEDALAIRARLLEAferaeqs 162
Cdd:pfam07992  81 LGtEVVSIDPGAKKVVLEelvdgDGETITYDRLVIATGARPRLPPIPGVELNvGFLVRTLDSAEALRLKLLPK------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 163 tddveirrllTFAIVGGGPTGVELAGTISELARatlardfsridprdtRVVLCEAGGRLLSGFDPALSTYAAEALTSMGV 242
Cdd:pfam07992 154 ----------RVVVVGGGYIGVELAAALAKLGK---------------EVTLIEALDRLLRAFDEEISAALEKALEKNGV 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 243 EVRIGTTVEAIDPTG----VVLGSER-IDTGAVLWCAGTEARPA-AEWLGIDGVRNGAVTVRSDCSVPgHPNIFAIGDVa 316
Cdd:pfam07992 209 EVRLGTSVKEIIGDGdgveVILKDGTeIDADLVVVAIGRRPNTElLEAAGLELDERGGIVVDEYLRTS-VPGIYAAGDC- 286

                         330       340
                  ....*....|....*....|.
gi 2176060514 317 sfetdgGKRLPALAPVAKQQG 337
Cdd:pfam07992 287 ------RVGGPELAQNAVAQG 301
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 85-350 5.38e-12

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 67.93  E-value: 5.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  85 NLSVLMAE-VTGVDIRARSVLLRNGHRLPYDYLVLATGSaSSFF----GQDnwREHTLVLKTIEDALAIRArlleafera 159
Cdd:TIGR02374  68 GITLYTGEtVIQIDTDQKQVITDAGRTLSYDKLILATGS-YPFIlpipGAD--KKGVYVFRTIEDLDAIMA--------- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 160 eqstddvEIRRLLTFAIVGGGPTGVELAGTISELARATLARDFSridPRDTRVVLCEAGGRLLsgfdpalstyaAEALTS 239
Cdd:TIGR02374 136 -------MAQRFKKAAVIGGGLLGLEAAVGLQNLGMDVSVIHHA---PGLMAKQLDQTAGRLL-----------QRELEQ 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 240 MGVEVRIGTTVEAIDPTGVVLG-----SERIDTGAVLWCAGTeaRPAAEWLGIDGVR-NGAVTVRSDCSVpGHPNIFAIG 313
Cdd:TIGR02374 195 KGLTFLLEKDTVEIVGATKADRirfkdGSSLEADLIVMAAGI--RPNDELAVSAGIKvNRGIIVNDSMQT-SDPDIYAVG 271

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2176060514 314 DVASFEtdgGKRLPALAPVAKQqgtyvGKLLAARIAG 350
Cdd:TIGR02374 272 ECAEHN---GRVYGLVAPLYEQ-----AKVLADHICG 300
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
42-408 2.36e-143

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 414.92  E-value: 2.36e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  42 AEVTLIDQTNHHLFQPLLYQVATAALSPSDIATATRVLMRGgSNLSVLMAEVTGVDIRARSVLLRNGHRLPYDYLVLATG 121
Cdd:COG1252    28 AEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRR-AGVRFIQGEVTGIDPEARTVTLADGRTLSYDYLVIATG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 122 SASSFFGQDNWREHTLVLKTIEDALAIRARLLEAFERAEQstddveiRRLLTFAIVGGGPTGVELAGTISELARATLArd 201
Cdd:COG1252   107 SVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER-------RRLLTIVVVGGGPTGVELAGELAELLRKLLR-- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 202 FSRIDPRDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAIDPTGVVLGS-ERIDTGAVLWCAGTEARP 280
Cdd:COG1252   178 YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDgEEIPADTVIWAAGVKAPP 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 281 AAEWLGIDGVRNGAVTVRSDCSVPGHPNIFAIGDVASFETDGGKRLPALAPVAKQQGTYVGKLLAARIAGrREPVAFRYR 360
Cdd:COG1252   258 LLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLAKNIAALLRG-KPLKPFRYR 336

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2176060514 361 DYGTMAVIGRSRAAAQFGRLRLTGFLAWLVWSLIHLMLLVDFRSRLVV 408
Cdd:COG1252   337 DKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLPGFRGRLRV 384
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 18-421 4.26e-79

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 251.61  E-value: 4.26e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  18 RPRVVIVGAGFGGMAAARALRGHAAEVTLIDQTNHHLFQPLLYQVATAALSPSDIATATRVLMRGGSNlSVLMAEVTGVD 97
Cdd:PTZ00318   10 KPNVVVLGTGWAGAYFVRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKLPN-RYLRAVVYDVD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  98 IRARSVLLRNGHR----------LPYDYLVLATGSASSFFGQDNWREHTLVLKTIEDALAIRARLLEAFERAEQSTDDVE 167
Cdd:PTZ00318   89 FEEKRVKCGVVSKsnnanvntfsVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPTTSVE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 168 IR-RLLTFAIVGGGPTGVELAGTISELARATLARDFSRIDPrDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRI 246
Cdd:PTZ00318  169 ERkRLLHFVVVGGGPTGVEFAAELADFFRDDVRNLNPELVE-ECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIRT 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 247 GTTVEAIDPTGVVLGS-ERIDTGAVLWCAGTEARPAAEWLGIDGVRNGAVTVRSDCSVPGHPNIFAIGDVASFETdggKR 325
Cdd:PTZ00318  248 KTAVKEVLDKEVVLKDgEVIPTGLVVWSTGVGPGPLTKQLKVDKTSRGRISVDDHLRVKPIPNVFALGDCAANEE---RP 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 326 LPALAPVAKQQGTYVGKLLAARIAGRREPVAFRYRDYGTMAVIGRSRAAAQFGRLRLTGFLAWLVWSLIHLMLLVDFRSR 405
Cdd:PTZ00318  325 LPTLAQVASQQGVYLAKEFNNELKGKPMSKPFVYRSLGSLAYLGNYSAIVQLGAFDLSGFKALLFWRSAYLTILGSWRSK 404

                         410
                  ....*....|....*..
gi 2176060514 406 LVVYVNWA-WAWFtyGR 421
Cdd:PTZ00318  405 LYVLVNWAgTAIF--GR 419
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 38-384 2.29e-42

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 152.27  E-value: 2.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  38 RGHAAEVTLIDQTNHHLFQP--LLYQVATAALSPSDIATAT-RVLMRGGSNLsVLMAEVTGVDIRARSVLLRNGHRLPYD 114
Cdd:COG0446     2 LGPDAEITVIEKGPHHSYQPcgLPYYVGGGIKDPEDLLVRTpESFERKGIDV-RTGTEVTAIDPEAKTVTLRDGETLSYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 115 YLVLATGSA---SSFFGQDNwrEHTLVLKTIEDALAIRARLleaferaeqstDDVEIRRLltfAIVGGGPTGVELAgtis 191
Cdd:COG0446    81 KLVLATGARprpPPIPGLDL--PGVFTLRTLDDADALREAL-----------KEFKGKRA---VVIGGGPIGLELA---- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 192 elarATLARdfsridpRDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAIDPTG---VVLGS-ERIDT 267
Cdd:COG0446   141 ----EALRK-------RGLKVTLVERAPRLLGVLDPEMAALLEEELREHGVELRLGETVVAIDGDDkvaVTLTDgEEIPA 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 268 GAVLWCAGteARPAAEWL---GIDGVRNGAVTV----RSdcsvpGHPNIFAIGDVASFET--DGGKRLPALAPVAKQQGT 338
Cdd:COG0446   210 DLVVVAPG--VRPNTELAkdaGLALGERGWIKVdetlQT-----SDPDVYAAGDCAEVPHpvTGKTVYIPLASAANKQGR 282

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2176060514 339 YVgkllAARIAGRREPvafrYRDYGTMAVIGRSRAAAQFGRLRLTG 384
Cdd:COG0446   283 VA----AENILGGPAP----FPGLGTFISKVFDLCIASTGTGRLLG 320
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 19-337 2.50e-37

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 138.22  E-value: 2.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  19 PRVVIVGAGFGGMAAARALRGHAAEVTLI-DQTNHHLFQPLLYQVATAALSPSDIATATRVLM--------RGGSNLSVL 89
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASLWADLYkrkeevvkKLNNGIEVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  90 MA-EVTGVDIRARSVLLR-----NGHRLPYDYLVLATGSASSFFGQDNWREH-TLVLKTIEDALAIRARLLEAferaeqs 162
Cdd:pfam07992  81 LGtEVVSIDPGAKKVVLEelvdgDGETITYDRLVIATGARPRLPPIPGVELNvGFLVRTLDSAEALRLKLLPK------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 163 tddveirrllTFAIVGGGPTGVELAGTISELARatlardfsridprdtRVVLCEAGGRLLSGFDPALSTYAAEALTSMGV 242
Cdd:pfam07992 154 ----------RVVVVGGGYIGVELAAALAKLGK---------------EVTLIEALDRLLRAFDEEISAALEKALEKNGV 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 243 EVRIGTTVEAIDPTG----VVLGSER-IDTGAVLWCAGTEARPA-AEWLGIDGVRNGAVTVRSDCSVPgHPNIFAIGDVa 316
Cdd:pfam07992 209 EVRLGTSVKEIIGDGdgveVILKDGTeIDADLVVVAIGRRPNTElLEAAGLELDERGGIVVDEYLRTS-VPGIYAAGDC- 286

                         330       340
                  ....*....|....*....|.
gi 2176060514 317 sfetdgGKRLPALAPVAKQQG 337
Cdd:pfam07992 287 ------RVGGPELAQNAVAQG 301
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
88-354 4.02e-36

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 137.20  E-value: 4.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  88 VLMAEVTGVDIRARSVLLRNGHRLPYDYLVLATGSAS---SFFGQDnwREHTLVLKTIEDALAIRARLLEAferaeqstd 164
Cdd:COG1251    74 RLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPrvpPIPGAD--LPGVFTLRTLDDADALRAALAPG--------- 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 165 dveiRRLltfAIVGGGPTGVELAgtiselarATLARdfsridpRDTRVVLCEAGGRLLSG-FDPALSTYAAEALTSMGVE 243
Cdd:COG1251   143 ----KRV---VVIGGGLIGLEAA--------AALRK-------RGLEVTVVERAPRLLPRqLDEEAGALLQRLLEALGVE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 244 VRIGTTVEAIDP----TGVVLGS-ERIDTGAVLWCAGteARPAAEWL---GIDgVRNGaVTVRSDCSVpGHPNIFAIGDV 315
Cdd:COG1251   201 VRLGTGVTEIEGddrvTGVRLADgEELPADLVVVAIG--VRPNTELAraaGLA-VDRG-IVVDDYLRT-SDPDIYAAGDC 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2176060514 316 ASFE-TDGGKRLPALAPVAKQQgtyvGKLLAARIAGRREP 354
Cdd:COG1251   276 AEHPgPVYGRRVLELVAPAYEQ----ARVAAANLAGGPAA 311
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 98-360 2.63e-23

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 101.70  E-value: 2.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  98 IRARSVLLRNGHRLPYDYLVLATGSASS---FFGQDnwreHTLVLkTIEDALAIRarlleaferaeqstddvEI-RRLlt 173
Cdd:COG1249   116 VDPHTVEVTGGETLTADHIVIATGSRPRvppIPGLD----EVRVL-TSDEALELE-----------------ELpKSL-- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 174 fAIVGGGPTGVELAGTiselaratlardFSRIDprdTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAI 253
Cdd:COG1249   172 -VVIGGGYIGLEFAQI------------FARLG---SEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTSV 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 254 DPT--GVVL------GSERIDTGAVLWCAGteARPAAEWLGID--GV---RNGAVTVRSDCSVpGHPNIFAIGDVASFet 320
Cdd:COG1249   236 EKTgdGVTVtledggGEEAVEADKVLVATG--RRPNTDGLGLEaaGVeldERGGIKVDEYLRT-SVPGIYAIGDVTGG-- 310

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2176060514 321 dggkrlPALAPVAKQQGTYVgkllAARIAGrREPVAFRYR 360
Cdd:COG1249   311 ------PQLAHVASAEGRVA----AENILG-KKPRPVDYR 339
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
93-332 1.53e-16

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 80.73  E-value: 1.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  93 VTGVDIRARSVLLrNGHRLPYDYLVLATGsASSFFGQDNWREHTLVLKTIEDALAIRARLLEAferaeqstddveiRRLL 172
Cdd:PRK04965   81 VTDIDAEAQVVKS-QGNQWQYDKLVLATG-ASAFVPPIPGRELMLTLNSQQEYRAAETQLRDA-------------QRVL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 173 tfaIVGGGPTGVELAgtiSELARAtlardfsridprDTRVVLCEAGGRLLSGFDPA-LSTYAAEALTSMGVEVRIGTTVE 251
Cdd:PRK04965  146 ---VVGGGLIGTELA---MDLCRA------------GKAVTLVDNAASLLASLMPPeVSSRLQHRLTEMGVHLLLKSQLQ 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 252 AIDPTG----VVLGSER-IDTGAVLWCAGTEARPA-AEWLGIDgVRNGAVtVRSDCSVPgHPNIFAIGDVASFEtdgGKR 325
Cdd:PRK04965  208 GLEKTDsgirATLDSGRsIEVDAVIAAAGLRPNTAlARRAGLA-VNRGIV-VDSYLQTS-APDIYALGDCAEIN---GQV 281


                  ....*..
gi 2176060514 326 LPALAPV 332
Cdd:PRK04965  282 LPFLQPI 288
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 92-354 4.92e-15

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 76.62  E-value: 4.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  92 EVTGVDIRARSVLLRNGHR-----LPYDYLVLATGSASSF--FGQDNwREHTLVLKTIEDALAIRARLleaferaeqstD 164
Cdd:PRK09564   78 EVVKVDAKNKTITVKNLKTgsifnDTYDKLMIATGARPIIppIKNIN-LENVYTLKSMEDGLALKELL-----------K 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 165 DVEIRRLLtfaIVGGGPTGVELAGTISELARATlardfsRIDPRDTRVvlceaggrLLSGFDPALSTYAAEALTSMGVEV 244
Cdd:PRK09564  146 DEEIKNIV---IIGAGFIGLEAVEAAKHLGKNV------RIIQLEDRI--------LPDSFDKEITDVMEEELRENGVEL 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 245 RIGTTVEAIDP----TGVVLGSERIDTGAVLWCAGTeaRPAAEWL---GIDGVRNGAVTV--RSDCSVpghPNIFAIGDV 315
Cdd:PRK09564  209 HLNEFVKSLIGedkvEGVVTDKGEYEADVVIVATGV--KPNTEFLedtGLKTLKNGAIIVdeYGETSI---ENIYAAGDC 283

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2176060514 316 ASF--ETDGGKRLPALAPVAKQQGTYVGKLLaariAGRREP 354
Cdd:PRK09564  284 ATIynIVSNKNVYVPLATTANKLGRMVGENL----AGRHVS 320
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 175-358 8.19e-13

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 69.79  E-value: 8.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGtiselARATLARDfsridprdtrVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAID 254
Cdd:PRK06416  176 VVIGGGYIGVEFAS-----AYASLGAE----------VTIVEALPRILPGEDKEISKLAERALKKRGIKIKTGAKAKKVE 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 255 PT--GVVL------GSERIDTGAVLWCAGTeaRPAAEWLGID--GVR--NGAVTVRSDC--SVPghpNIFAIGDVAsfet 320
Cdd:PRK06416  241 QTddGVTVtledggKEETLEADYVLVAVGR--RPNTENLGLEelGVKtdRGFIEVDEQLrtNVP---NIYAIGDIV---- 311

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2176060514 321 dGGkrlPALAPVAKQQGTYVgkllAARIAGRREPVAFR 358
Cdd:PRK06416  312 -GG---PMLAHKASAEGIIA----AEAIAGNPHPIDYR 341
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 85-350 5.38e-12

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 67.93  E-value: 5.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  85 NLSVLMAE-VTGVDIRARSVLLRNGHRLPYDYLVLATGSaSSFF----GQDnwREHTLVLKTIEDALAIRArlleafera 159
Cdd:TIGR02374  68 GITLYTGEtVIQIDTDQKQVITDAGRTLSYDKLILATGS-YPFIlpipGAD--KKGVYVFRTIEDLDAIMA--------- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 160 eqstddvEIRRLLTFAIVGGGPTGVELAGTISELARATLARDFSridPRDTRVVLCEAGGRLLsgfdpalstyaAEALTS 239
Cdd:TIGR02374 136 -------MAQRFKKAAVIGGGLLGLEAAVGLQNLGMDVSVIHHA---PGLMAKQLDQTAGRLL-----------QRELEQ 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 240 MGVEVRIGTTVEAIDPTGVVLG-----SERIDTGAVLWCAGTeaRPAAEWLGIDGVR-NGAVTVRSDCSVpGHPNIFAIG 313
Cdd:TIGR02374 195 KGLTFLLEKDTVEIVGATKADRirfkdGSSLEADLIVMAAGI--RPNDELAVSAGIKvNRGIIVNDSMQT-SDPDIYAVG 271

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2176060514 314 DVASFEtdgGKRLPALAPVAKQqgtyvGKLLAARIAG 350
Cdd:TIGR02374 272 ECAEHN---GRVYGLVAPLYEQ-----AKVLADHICG 300
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 175-261 1.71e-11

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 59.91  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGTISELAratlardfsridprdTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAID 254
Cdd:pfam00070   3 VVVGGGYIGLELAGALARLG---------------SKVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIE 67


                  ....*..
gi 2176060514 255 PTGVVLG 261
Cdd:pfam00070  68 GNGDGVV 74
trypano_reduc TIGR01423
trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of ...
 110-337 3.28e-11

trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of spermidine, is (in its reduced form) an important antioxidant found in trypanosomatids (Crithidia, Leishmania, Trypanosoma). This model describes trypanothione reductase, a possible antitrypanosomal drug target closely related to some forms of glutathione reductase.


Pssm-ID: 200098 [Multi-domain]  Cd Length: 486  Bit Score: 64.99  E-value: 3.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 110 RLPYDYLVLATGSassffgqdnWREHtlvLKTIEDALAIRARllEAFERAEQStddveiRRLLTfaiVGGGPTGVELAGT 189
Cdd:TIGR01423 149 RLQAEHILLATGS---------WPQM---LGIPGIEHCISSN--EAFYLDEPP------RRVLT---VGGGFISVEFAGI 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 190 iselaratlardFSRIDPRDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAI--DPTG---VVLGS-E 263
Cdd:TIGR01423 206 ------------FNAYKPRGGKVTLCYRNNMILRGFDSTLRKELTKQLRANGINIMTNENPAKVtlNADGskhVTFESgK 273

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2176060514 264 RIDTGAVLWCAGTEARPAAEWLGIDGVR---NGAVTVrSDCSVPGHPNIFAIGDVasfeTDggkRLpALAPVAKQQG 337
Cdd:TIGR01423 274 TLDVDVVMMAIGRVPRTQTLQLDKVGVEltkKGAIQV-DEFSRTNVPNIYAIGDV----TD---RV-MLTPVAINEG 341
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 107-360 1.70e-10

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 62.89  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 107 NGHRLPYDYLVLATGSASSFF-GQDNWREHTLVlkTIEDALAIRarllEAFERaeqstddveirrlltFAIVGGGPTGVE 185
Cdd:PRK06292  125 NGERIEAKNIVIATGSRVPPIpGVWLILGDRLL--TSDDAFELD----KLPKS---------------LAVIGGGVIGLE 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 186 LAgtiseLAratlardFSRIdprDTRVVLCEAGGRLLSGFDPALSTYAAEALTSMgVEVRIGTTVEAIDPTGVVLGSERI 265
Cdd:PRK06292  184 LG-----QA-------LSRL---GVKVTVFERGDRILPLEDPEVSKQAQKILSKE-FKIKLGAKVTSVEKSGDEKVEELE 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 266 DTG--------AVLWCAGTeaRPAAEWLGID--GV---RNGAVTVrSDCSVPGHPNIFAIGDVAsfetdgGKRLpaLAPV 332
Cdd:PRK06292  248 KGGktetieadYVLVATGR--RPNTDGLGLEntGIeldERGRPVV-DEHTQTSVPGIYAAGDVN------GKPP--LLHE 316

                         250       260
                  ....*....|....*....|....*...
gi 2176060514 333 AKQQGtyvgkLLAARIAGRREPVAFRYR 360
Cdd:PRK06292  317 AADEG-----RIAAENAAGDVAGGVRYH 339
PRK06116 PRK06116
glutathione reductase; Validated
 175-333 1.14e-09

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 60.17  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGTISEL-ARATLardFSRidprdtrvvlceaGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAI 253
Cdd:PRK06116  171 AVVGAGYIAVEFAGVLNGLgSETHL---FVR-------------GDAPLRGFDPDIRETLVEEMEKKGIRLHTNAVPKAV 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 254 DPTG-----VVL-GSERIDTGAVLWCAGTEarPAAEWLGID--GVR---NGAVTV--RSDCSVPGhpnIFAIGDVasfeT 320
Cdd:PRK06116  235 EKNAdgsltLTLeDGETLTVDCLIWAIGRE--PNTDGLGLEnaGVKlneKGYIIVdeYQNTNVPG---IYAVGDV----T 305

                         170
                  ....*....|...
gi 2176060514 321 DGgkrlPALAPVA 333
Cdd:PRK06116  306 GR----VELTPVA 314
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 67-323 2.97e-09

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 58.78  E-value: 2.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  67 LSPSDIATATRVLMRGGSNLSVLMAEvtgvdirARSVLLRNGHRLPYDYLVLATGSASSFFG-QDNWREHTLVLKTIEDA 145
Cdd:PRK09754   62 VLPANWWQENNVHLHSGVTIKTLGRD-------TRELVLTNGESWHWDQLFIATGAAARPLPlLDALGERCFTLRHAGDA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 146 lairARLLEAFEraeqstddvEIRRLLtfaIVGGGPTGVELAGTISEL-ARATLardfsrIDPRDTRVVLCEAggrllsg 224
Cdd:PRK09754  135 ----ARLREVLQ---------PERSVV---IVGAGTIGLELAASATQRrCKVTV------IELAATVMGRNAP------- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 225 fdPALSTYAAEALTSMGVEVRIGTTVE-AIDPTGVVL---GSERIDTGAVLWCAGTEARpaaEWLGIDG--VRNGAVTVR 298
Cdd:PRK09754  186 --PPVQRYLLQRHQQAGVRILLNNAIEhVVDGEKVELtlqSGETLQADVVIYGIGISAN---DQLAREAnlDTANGIVID 260

                         250       260
                  ....*....|....*....|....*
gi 2176060514 299 SDCSVpGHPNIFAIGDVASFETDGG 323
Cdd:PRK09754  261 EACRT-CDPAIFAGGDVAITRLDNG 284
PRK07251 PRK07251
FAD-containing oxidoreductase;
173-315 7.94e-09

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 57.45  E-value: 7.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 173 TFAIVGGGPTGVELAGTISELAratlardfsridprdTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEA 252
Cdd:PRK07251  159 RLGIIGGGNIGLEFAGLYNKLG---------------SKVTVLDAASTILPREEPSVAALAKQYMEEDGITFLLNAHTTE 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2176060514 253 IDPTG--VVL----GSERIDtgAVLWCAGTeaRPAAEWLG-----IDGVRNGAVTVRSDC--SVPGhpnIFAIGDV 315
Cdd:PRK07251  224 VKNDGdqVLVvtedETYRFD--ALLYATGR--KPNTEPLGlentdIELTERGAIKVDDYCqtSVPG---VFAVGDV 292
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
175-351 1.19e-08

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 57.09  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGTISELaratlardfsridprDTRVVLCEAGGRLLSGFDP----ALSTyaaeALTSMGVEVRIGTTV 250
Cdd:PRK05249  179 IIYGAGVIGCEYASIFAAL---------------GVKVTLINTRDRLLSFLDDeisdALSY----HLRDSGVTIRHNEEV 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 251 EAIDPT--GVVL----GSeRIDTGAVLWCAG----TEArpaaewLGIDGV------RnGAVTVRSD--CSVPghpNIFAI 312
Cdd:PRK05249  240 EKVEGGddGVIVhlksGK-KIKADCLLYANGrtgnTDG------LNLENAgleadsR-GQLKVNENyqTAVP---HIYAV 308

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2176060514 313 GDVASFetdggkrlPALAPVAKQQGtyvgkllaaRIAGR 351
Cdd:PRK05249  309 GDVIGF--------PSLASASMDQG---------RIAAQ 330
PRK06370 PRK06370
FAD-containing oxidoreductase;
175-315 2.96e-07

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 52.51  E-value: 2.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGTiselaratlardFSRIDprdTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAI- 253
Cdd:PRK06370  175 VIIGGGYIGLEFAQM------------FRRFG---SEVTVIERGPRLLPREDEDVAAAVREILEREGIDVRLNAECIRVe 239

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2176060514 254 -DPTGVVL------GSERIDTGAVLWCAGTeaRPAAEWLGID--GV---RNGAVTV----RSdcSVPGhpnIFAIGDV 315
Cdd:PRK06370  240 rDGDGIAVgldcngGAPEITGSHILVAVGR--VPNTDDLGLEaaGVetdARGYIKVddqlRT--TNPG---IYAAGDC 310
PRK14989 PRK14989
nitrite reductase subunit NirD; Provisional
 85-318 4.37e-07

nitrite reductase subunit NirD; Provisional


Pssm-ID: 184951 [Multi-domain]  Cd Length: 847  Bit Score: 52.43  E-value: 4.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514  85 NLSVLMAE-VTGVDIRARSVLLRNGHRLPYDYLVLATGS---ASSFFGQDNwrEHTLVLKTIEDALAIRArlleaferae 160
Cdd:PRK14989   73 GIKVLVGErAITINRQEKVIHSSAGRTVFYDKLIMATGSypwIPPIKGSET--QDCFVYRTIEDLNAIEA---------- 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 161 qstddvEIRRLLTFAIVGGGPTGVELAGTISELARATLARDFSridPRDTRVVLCEAGGRLLSgfdpalstyaaEALTSM 240
Cdd:PRK14989  141 ------CARRSKRGAVVGGGLLGLEAAGALKNLGVETHVIEFA---PMLMAEQLDQMGGEQLR-----------RKIESM 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 241 GVEVRIGTTVEAIDPTGV--------VLGSErIDTGAVLWCAGTEARPA-AEWLGIDGVRNGAVTVRSDCSVpGHPNIFA 311
Cdd:PRK14989  201 GVRVHTSKNTLEIVQEGVearktmrfADGSE-LEVDFIVFSTGIRPQDKlATQCGLAVAPRGGIVINDSCQT-SDPDIYA 278


                  ....*..
gi 2176060514 312 IGDVASF 318
Cdd:PRK14989  279 IGECASW 285
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 175-368 3.98e-06

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 49.15  E-value: 3.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGTISELAratlardfsridprdTRVVLCEAGGRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAID 254
Cdd:PRK06327  187 AVIGAGVIGLELGSVWRRLG---------------AEVTILEALPAFLAAADEQVAKEAAKAFTKQGLDIHLGVKIGEIK 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 255 PT--GVVLGSERIDTGA-------VLWCAGTeaRPAAEWLGIDGV-----RNGAVTVRSDCSVpGHPNIFAIGDVAsfet 320
Cdd:PRK06327  252 TGgkGVSVAYTDADGEAqtlevdkLIVSIGR--VPNTDGLGLEAVglkldERGFIPVDDHCRT-NVPNVYAIGDVV---- 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2176060514 321 dggkRLPALAPVAKQQGTYVgkllAARIAGRREPVafryrDYGTM-AVI 368
Cdd:PRK06327  325 ----RGPMLAHKAEEEGVAV----AERIAGQKGHI-----DYNTIpWVI 360
PLN02507 PLN02507
glutathione reductase
 176-342 7.89e-05

glutathione reductase


Pssm-ID: 215281 [Multi-domain]  Cd Length: 499  Bit Score: 44.81  E-value: 7.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 176 IVGGGPTGVELAGTISELArATLARDFSRIDPrdtrvvlceaggrlLSGFDPALSTYAAEALTSMGVEVRIGTTVEAIDP 255
Cdd:PLN02507  208 VLGGGYIAVEFASIWRGMG-ATVDLFFRKELP--------------LRGFDDEMRAVVARNLEGRGINLHPRTNLTQLTK 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 256 TG-----VVLGSERIDTGAVLWCAG---TEARPAAEWLGIDGVRNGAVTVrSDCSVPGHPNIFAIGDVASfetdggkRLp 327
Cdd:PLN02507  273 TEggikvITDHGEEFVADVVLFATGrapNTKRLNLEAVGVELDKAGAVKV-DEYSRTNIPSIWAIGDVTN-------RI- 343

                         170
                  ....*....|....*
gi 2176060514 328 ALAPVAKQQGTYVGK 342
Cdd:PLN02507  344 NLTPVALMEGTCFAK 358
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
175-317 9.90e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 43.96  E-value: 9.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGTISELARatlardfsridprdtRVVLCEAGGRLlsgfdPALSTYAAEALTSMGVEVRIGTTVEAID 254
Cdd:COG0492   145 VVVGGGDSALEEALYLTKFAS---------------KVTLIHRRDEL-----RASKILVERLRANPKIEVLWNTEVTEIE 204

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2176060514 255 ----PTGVVL-----GSER-IDTGAVLWCAGteARPAAEWL---GIDGVRNGAVTVRSDC--SVPGhpnIFAIGDVAS 317
Cdd:COG0492   205 gdgrVEGVTLknvktGEEKeLEVDGVFVAIG--LKPNTELLkglGLELDEDGYIVVDEDMetSVPG---VFAAGDVRD 277
PLN02546 PLN02546
glutathione reductase
 175-360 1.08e-04

glutathione reductase


Pssm-ID: 215301 [Multi-domain]  Cd Length: 558  Bit Score: 44.48  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGVELAGTISELAratlardfsridpRDTRVVLCEAggRLLSGFDPALSTYAAEALTSMGVEVRIGTTVEAID 254
Cdd:PLN02546  256 AIVGGGYIALEFAGIFNGLK-------------SDVHVFIRQK--KVLRGFDEEVRDFVAEQMSLRGIEFHTEESPQAII 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 255 PTGVVLGSERIDTGAVLWCA----GTEARPAAEWLGIDGV-----RNGAVTVR--SDCSVpghPNIFAIGDVasfeTDgg 323
Cdd:PLN02546  321 KSADGSLSLKTNKGTVEGFShvmfATGRKPNTKNLGLEEVgvkmdKNGAIEVDeySRTSV---PSIWAVGDV----TD-- 391

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2176060514 324 kRLpALAPVAKQQGTYVGKLLAAriagrREPVAFRYR 360
Cdd:PLN02546  392 -RI-NLTPVALMEGGALAKTLFG-----NEPTKPDYR 421
TGR TIGR01438
thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member ...
 221-359 1.34e-04

thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member of the pyridine nucleotide disulfide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports interpreted as a stop codon). In some members of this subfamily, Cys-SeCys-Gly is replaced by Cys-Cys-Gly. The reach of the selenium atom at the C-term arm of the protein is proposed to allow broad substrate specificity.


Pssm-ID: 273624 [Multi-domain]  Cd Length: 484  Bit Score: 44.07  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 221 LLSGFDPALSTYAAEALTSMGVEVRIGTT---VEAIDPTGVV-------LGSERIDTgaVLWCAGTEarPAAEWLGIDGV 290
Cdd:TIGR01438 214 LLRGFDQDCANKVGEHMEEHGVKFKRQFVpikVEQIEAKVLVeftdstnGIEEEYDT--VLLAIGRD--ACTRKLNLENV 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2176060514 291 ------RNGAVTVrSDCSVPGHPNIFAIGDVAsfetdggKRLPALAPVAKQqgtyVGKLLAARI-AGRREPVAFRY 359
Cdd:TIGR01438 290 gvkinkKTGKIPA-DEEEQTNVPYIYAVGDIL-------EDKPELTPVAIQ----AGRLLAQRLfKGSTVICDYEN 353
PTZ00052 PTZ00052
thioredoxin reductase; Provisional
 130-386 3.86e-04

thioredoxin reductase; Provisional


Pssm-ID: 185416 [Multi-domain]  Cd Length: 499  Bit Score: 42.89  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 130 DNWREHTLVLKTIEDALAIRARLLEAFERAEQ---STDDVeirrlltFA---------IVGGGPTGVELAGTISELA--- 194
Cdd:PTZ00052  136 DNSQEETITAKYILIATGGRPSIPEDVPGAKEysiTSDDI-------FSlskdpgktlIVGASYIGLETAGFLNELGfdv 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 195 ----RATLARDFSRIDPRDTRVVLCEAGGRLLSGFDPalstyaaEALTSMGVEVRigttVEAIDPTgvvlgSERIDTgaV 270
Cdd:PTZ00052  209 tvavRSIPLRGFDRQCSEKVVEYMKEQGTLFLEGVVP-------INIEKMDDKIK----VLFSDGT-----TELFDT--V 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 271 LWCAGTEARPAA---EWLGIDGVRNGAVTVRSDCSvpGHPNIFAIGDVAsfetdggKRLPALAPVAKQqgtyVGKLLAAR 347
Cdd:PTZ00052  271 LYATGRKPDIKGlnlNAIGVHVNKSNKIIAPNDCT--NIPNIFAVGDVV-------EGRPELTPVAIK----AGILLARR 337

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2176060514 348 I-AGRREPVAFRYR--------DYGTmavIGRS--RAAAQFGRLRLTGFL 386
Cdd:PTZ00052  338 LfKQSNEFIDYTFIpttiftpiEYGA---CGYSseAAIAKYGEDDIEEYL 384
PRK07846 PRK07846
mycothione reductase; Reviewed
 176-317 7.95e-04

mycothione reductase; Reviewed


Pssm-ID: 181142 [Multi-domain]  Cd Length: 451  Bit Score: 41.48  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 176 IVGGGPTGVELAGTISELAratlardfsridprdTRVVLCEAGGRLLSGFDPALSTYAAEaLTSMGVEVRIGTTVEAIDP 255
Cdd:PRK07846  171 IVGGGFIAAEFAHVFSALG---------------VRVTVVNRSGRLLRHLDDDISERFTE-LASKRWDVRLGRNVVGVSQ 234

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2176060514 256 TG----VVLGSERIDTGAVLWCAgTEARPAAEWL-----GIDGVRNGAVTVRSDC--SVPGhpnIFAIGDVAS 317
Cdd:PRK07846  235 DGsgvtLRLDDGSTVEADVLLVA-TGRVPNGDLLdaaaaGVDVDEDGRVVVDEYQrtSAEG---VFALGDVSS 303
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
193-323 3.15e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 39.50  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 193 LARATLARDFSRIDPRDTR-VVLCEAGGRLlsgfDPALSTYA-AEALTSMGVEVRIGTTVEAIDPTG-----VVLGSERI 265
Cdd:COG0665   119 LDAAELREREPGLGSPDYAgGLYDPDDGHV----DPAKLVRAlARAARAAGVRIREGTPVTGLEREGgrvtgVRTERGTV 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2176060514 266 DTGAVLWCAGTEARPAAEWLGID----GVRNGAVTVRSDCSVPGHPNIFAIGDVASFETDGG 323
Cdd:COG0665   195 RADAVVLAAGAWSARLLPMLGLRlplrPVRGYVLVTEPLPDLPLRPVLDDTGVYLRPTADGR 256
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
175-291 6.84e-03

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 38.18  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2176060514 175 AIVGGGPTGveLAGTIsELARATLardfsridprdtRVVLCEA---GGRLLS--------GFD-----PALSTYAAEALT 238
Cdd:COG0492     4 VIIGAGPAG--LTAAI-YAARAGL------------KTLVIEGgepGGQLATtkeienypGFPegisgPELAERLREQAE 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2176060514 239 SMGVEVRIgTTVEAIDPTG----VVLGS-ERIDTGAVLWCAGTEARpaaeWLGIDGVR 291
Cdd:COG0492    69 RFGAEILL-EEVTSVDKDDgpfrVTTDDgTEYEAKAVIIATGAGPR----KLGLPGEE 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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