|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-915 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1092.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 4 NPSFPDMEESVLKYWDADGTFKKSVEQRPSGdnsgNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVF 83
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEKSREARAGR----PKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 84 GWDTHGLPAELEAEKELGIeNKSQIDKMGLAAFNDACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAF 163
Cdd:COG0060 91 GWDCHGLPIELKVEKELGI-KKKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 164 KQLYEKGLAYKGYRVLPYCPKDETPLSNHELrmdadVYQNRQDISVSVAVKMRD-------EDAYAVFWTTTPWTVPGNL 236
Cdd:COG0060 170 KKLYEKGLLYKGLKPVPWCPRCGTALAEAEV-----EYKDVTSPSIYVKFPVKDekallllEDAYLVIWTTTPWTLPANL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 237 AIVVGPDIDYSLVQPTEGRfagkKLYFATALLPQFAKELG-DNYTVLKELKGSDLVGRRYWPVFPYLADGKatsqdgeqg 315
Cdd:COG0060 245 AVAVHPDIDYVLVEVTGGE----RLILAEALVEAVLKELGiEDYEVLATFKGAELEGLRYEHPFYYVVGYD--------- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 316 edpNAFTIYPADYVETTEGTGLVHQA-VYGEDDINTLNKYGVRTVDYLDEGCRFTSLVPDYQGTRVFEANTPIVRDLRHH 394
Cdd:COG0060 312 ---RAHPVILGDYVTTEDGTGIVHTApGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKER 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 395 tGAladipedhrafLVQERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEINWIPDNvKDGQFGKWLSNA 474
Cdd:COG0060 389 -GA-----------LLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 475 RDWSISRNRYWGSPIPVWVSDDPAYP--RVDVYGSLAELKRDFGRyptDDKGKINLHRPWVDSlTRPNPDdptGKSTMRR 552
Cdd:COG0060 456 PDWCISRQRYWGVPIPIWVCEDCGELhrTEEVIGSVAELLEEEGA---DAWFELDLHRPFLDE-TLKCPK---CGGTMRR 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 553 ISDVLDCWFESGSMPFAQfhypFENKEyfEQHFPGDYVVEYIGQTRGWFYTLHIMAGALFDSPAFRNVICHGIVLGSDGQ 632
Cdd:COG0060 529 VPDVLDVWFDSGSMHFAV----LENRE--ELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGR 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 633 KMSKHLRNYPDVNGVFNKYGSDAMRWFLMSSPilRGGNLIVTAGGIRDtVRQIMLPLWSTYYFFTlyANAAhdgqGLEAR 712
Cdd:COG0060 603 KMSKSLGNVVDPQEVIDKYGADILRLWVASSD--YWGDLRFSDEILKE-VRDVYRRLRNTYRFLL--ANLD----DFDPA 673
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 713 QVkASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDET------AFNT 785
Cdd:COG0060 674 ED-AVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCvEDLSNWYLDISKDRLYTEAADsldrraAQTT 752
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 786 LYTALEVLCRVMAPLAPMETETIWRGLTGG--ESVHLTDWPylteqghkDAPQTKLgqvlrqDDGLVAAMEKVREVVSAS 863
Cdd:COG0060 753 LYEVLETLVRLLAPILPFTAEEIWQNLPGEaeESVHLADWP--------EVDEELI------DEELEAKWDLVREVRSAV 818
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 2161621985 864 L----ALRKVNqiRVRQPLSKLTIVVSDT---AAIKPCEDIFKSELNVKTVEYTTVEDA 915
Cdd:COG0060 819 LkaleAARKEK--LIRQPLEAAVVLYADEelaAALESLGDLLAEELNVSEVELVDDAED 875
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
3-1043 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 845.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 3 PNPSFPDMEESVLKYWDADGTFK---KSVEQRPsgdnsgnEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRV 79
Cdd:PLN02882 6 KDFSFPKQEEKILSLWSEIDAFKtqlKRTEGLP-------EYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 80 NRVFGWDTHGLPAELEAEKELGIENKSQIDKMGLAAFNDACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESV 159
Cdd:PLN02882 79 TRRFGWDCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 160 IWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHELRMDadvYQNRQDISVSVAVKMRDEDAYAVF--WTTTPWTVPGNLA 237
Cdd:PLN02882 159 WWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLN---YKDVSDPAVMVSFPIVGDPDNASFvaWTTTPWTLPSNLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 238 IVVGPDIDYSLVQpteGRFAGKKLYFATALLPQF------------AKELGDNYTVLKELKGSDLVGRRYWPVFPYLADG 305
Cdd:PLN02882 236 LCVNPNFTYVKVR---NKYTGKVYIVAESRLSALptakpkskkgskPENAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEF 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 306 KatsqdgeqgedPNAFTIYPADYVETTEGTGLVHQA-VYGEDDI------NTLNKYGVRTVDYLDEGCrFTSLVPDYQGT 378
Cdd:PLN02882 313 S-----------DTAFRVVADDYVTDDSGTGVVHCApAFGEDDYrvclanGIIEKGGNLPVPVDDDGC-FTEKVTDFSGR 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 379 RVFEANTPIVrdlrhhtgalADIPEDHRafLVQERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEINWI 458
Cdd:PLN02882 381 YVKDADKDII----------AAIKAKGR--LVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWV 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 459 PDNVKDGQFGKWLSNARDWSISRNRYWGSPIPVWVSDDPAypRVDVYGSLAELKRDFGRYPTDdkgkinLHRPWVDSLTR 538
Cdd:PLN02882 449 PDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWISDDGE--EVVVIGSIAELEKLSGVKVTD------LHRHFIDHITI 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 539 PNPDDPtGKSTMRRISDVLDCWFESGSMPFAQFHYPFENKEYFEQHFPGDYVVEYIGQTRGWFYTLHIMAGALFDSPAFR 618
Cdd:PLN02882 521 PSSRGP-EFGVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFK 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 619 NVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLMSSPILRGGNLIVTAGGIRDTVRQIMLPLWSTYYFFTl 698
Cdd:PLN02882 600 NLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLINSPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLV- 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 699 yANAAH-DGQGLEARQVKASEV--GSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYIDLLTNWYVRNSRDRF 775
Cdd:PLN02882 679 -QNAKRlEVEGGAPFVPLDLAKlqNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRL 757
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 776 W-----NEDETAFNTLYTALEVLCRVMAPLAPMETETIW----RGLTGG-ESVHLTDWPYLTEQghkdapqtklgqvlRQ 845
Cdd:PLN02882 758 KgrtgeEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYqnlrKVLPGSeESIHYCSFPQVDEG--------------EL 823
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 846 DDGLVAAMEKVREVVSASLALRKVNQIRVRQPLSKLTIVVSDTAAIK----PCEDIFKSELNVKTVEytTVEDAGKHdlt 921
Cdd:PLN02882 824 DERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDditgKLKEYVLEELNVRSLV--PCNDPLKY--- 898
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 922 VINELKVNARAAGPRLGKQVQLAIKAAKTGSWKK----DQSGAVTVQT---PQGDIALepgEYELNSRvEEAHASDTDsi 994
Cdd:PLN02882 899 ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDilefEKAGEVTIAGhtlKAGDIKV---VRDFKRP-EGVSKEDID-- 972
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*....
gi 2161621985 995 vsAPLPTGGFVLLDTELTDDLLAEGYARDTIRLVQDERKAAGLDISDRI 1043
Cdd:PLN02882 973 --AAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKV 1019
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
5-892 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 803.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 5 PSFPDMEESVLKYWDADGTFKKSVEQRpsgdNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFG 84
Cdd:TIGR00392 6 GNLSKREEKILAFWQENDIFEKVKKLN----KGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 85 WDTHGLPAELEAEKELGIENKSQIDKMGLAAFNDACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAFK 164
Cdd:TIGR00392 82 WDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 165 QLYEKGLAYKGYRVLPYCPKDETPLSNHELRMdADVYQNRQDISVSVAVKMRDED--------AYAVFWTTTPWTVPGNL 236
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEY-KENYKDVKDPSIYVKFPVKKDKktylkvklSSLLIWTTTPWTLPSNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 237 AIVVGPDIDYSLVQpTEGRfaGKKLYFATALLPQFAKELGDNYTVLKELKGSDLVGRRYWPVFPYLADGKatsqdgeqge 316
Cdd:TIGR00392 241 AIAVHPDFEYALVQ-DNTK--VEYFILAKKLVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQL---------- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 317 DPNAFTIYPADYVETTEGTGLVHQA-VYGEDDINTLNKYGVRTVDYLDEGCRFTSLVPDYQGTRVFEANTPIVRDLRHHT 395
Cdd:TIGR00392 308 KEGAPVVIGGDHVTTEDGTGIVHTApGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVKDADKDIIKANKIII 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 396 GALADipedhRAFLVQERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEINWIPDNVKdGQFGKWLSNAR 475
Cdd:TIGR00392 388 EQLKD-----KGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGE-GRFGNWLENRP 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 476 DWSISRNRYWGSPIPVWVSDDPAYPRVDvyGSLAELKRDFgRYPTDDKGKINLHRPWVDSLTRPNPDdptgKSTMRRISD 555
Cdd:TIGR00392 462 DWCISRQRYWGIPIPIWYCEDTGEPIVV--GSIEELIELI-ELKGIDAWFEDLHRDFLDKITLKSGD----GGEYRRVPD 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 556 VLDCWFESGSMPFAQFHYPFENkEYFEQHFPGDYVVEYIGQTRGWFYTLHIMAGALFDSPAFRNVICHGIVLGSDGQKMS 635
Cdd:TIGR00392 535 VLDVWFDSGSMPYASIHYPFEN-EKFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMS 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 636 KHLRNYPDVNGVFNKYGSDAMRWFLMSSpiLRGGNLIVTAGGIRDTVRQIMLPLWSTYYFFTLYANaAHDGQGLEarqvK 715
Cdd:TIGR00392 614 KSLGNVVDPLKVINKYGADILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTYAN-LDKFDPLF----N 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 716 ASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYIDL-LTNWYVRNSRDRFWNEDET-----AFNTLYTA 789
Cdd:TIGR00392 687 SVAVEKFPEEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDndkraAQTTLYYA 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 790 LEVLCRVMAPLAPMETETIWRGLTGG---ESVHLTDWPYLTEQghkdapqtklgqvlRQDDGLVAAMEKVREVVSASLAL 866
Cdd:TIGR00392 767 LLTLVRLLAPFLPHTAEEIYQNLPGGeeeESVHLNLWPEVDEE--------------FIDEALEANMAIVREIVEAFLAL 832
|
890 900
....*....|....*....|....*.
gi 2161621985 867 RKVNQIRVRQPLSKLTIVVSDTAAIK 892
Cdd:TIGR00392 833 RDAANKKLRQPLKELVIGKSLEAVLK 858
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
1-1038 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 637.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 1 MTPNPSFPDMEESVLKYW---DADGTFKKSVEQRPSgdnsgneFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGR 77
Cdd:PTZ00427 68 VSENPNIVEEEEKVLKYWksiDAFNTSNKLAKNKKA-------YIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 78 RVNRVFGWDTHGLPAELEAEKELGIENKSQIDKMGLAAFNDACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYME 157
Cdd:PTZ00427 141 SVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFME 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 158 SVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHELRMDadvYQNRQDISVSVAV-------KMRDE-----------D 219
Cdd:PTZ00427 221 SVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLN---YKDTPDPSIIISFvlcsdfpKVEEEcnieedkqllgE 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 220 AYAVF-----------------------------WTTTPWTVPGNLAIVVGPDIDYSLVQPTEgrfAGKKLYFATALLPQ 270
Cdd:PTZ00427 298 KYSVLynnkrensnngnnnstnnvcyaqhseilaWTTTPWTLPSNLALCVNEHFTYLRIHHVK---SNRVVIVGECRLEW 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 271 FAKELG---DNYTVLKELKGSDLVGRRYWPVFPYLADGKATSQdgeqgedpNAFTIYPADYVETTEGTGLVHQA-VYGED 346
Cdd:PTZ00427 375 IMKELKwnvEDLKIVNRFKGKELKGLRYKPLFTNFYEKYNFKE--------RAYKILADDFVTDDAGTGIVHCApTYGED 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 347 DINTLNKYGVRT------VDYLDEGCRFTSLVPDYQGTRVFEANTPIVRDLRhhtgaladipEDHRafLVQERSYIHSYP 420
Cdd:PTZ00427 447 DFRVCKKNGVIDpeknifIDPLDANGYFTNEVEEVQNLYIKEADNVIKKKLK----------NENR--LLSNNTIVHSYP 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 421 HCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEINWIPDNVKDGQFGKWLSNARDWSISRNRYWGSPIPVWVsdDPAYP 500
Cdd:PTZ00427 515 FCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWA--DEKME 592
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 501 RVDVYGSLAELKRDFGRYPTDDkgkinLHRPWVDSLtrpNPDDPTGKS--TMRRISDVLDCWFESGSMPFAQFHYPFEN- 577
Cdd:PTZ00427 593 TVICVESIKHLEELSGVKNIND-----LHRHFIDHI---EIKNPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPFSTe 664
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 578 KEYFEQHFPGDYVVEYIGQTRGWFYTLHIMAGALFDSPAFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMR 657
Cdd:PTZ00427 665 KEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLR 744
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 658 WFLMSSPILRGGNLIVTAGGIRDTVRQIMLPLWSTYYFF----TLYanaahdgQGLEARQVKASEV---GSLSRMDRYLL 730
Cdd:PTZ00427 745 LYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFsqevTRY-------ECLNKKQFLFNTDyiyKNDNIMDQWIF 817
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 731 ARTHNLVSSVETSLDQFAISDACDAVADYIDLLTNWYVRNSRDRF---WNEDET--AFNTLYTALEVLCRVMAPLAPMET 805
Cdd:PTZ00427 818 SSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMrgsLGEENClqSLCTTYRTLHLFTVLMAPFTPFIT 897
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 806 ETIWRGL----TGGESVHLTDWPYLTEQG------HKDAPQTKLGQVLRQ---DDGLVAAMEKVREVVSASLALRKVNQI 872
Cdd:PTZ00427 898 EYIYQQLrrvkSTNEHNENNETGNTKEGDlnrgviHKSVHFIMLPQVDEKyiiDYEIIELIEKMKDVILLGRVLRERRKV 977
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 873 RVRQPLSKLTIVVSDTAAIKPCEDI---FKSELNVKTVEYTtvEDAGKHDLTVINelkvNARAAGPRLG---KQVQLAIK 946
Cdd:PTZ00427 978 ASKKPLKSITILHPNESYFKNFDQIsnyIKEELNVLNVECS--NDTSCLDFSAIP----NYKTLGVKLGynlKKVQNKIK 1051
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 947 AAKTGSWKK-DQSGAVTVQ--TPQGDIALEPGEYELNSRVEEAHASDTDSIvsaplptggfvLLDTELTDDLLAEGYARD 1023
Cdd:PTZ00427 1052 NMDSESIKLyQQEGKITLDnvTLEGDDIIIQMKPNFQNDNTDIISNNYVTI-----------LMDFTTDQQLENMASARE 1120
|
1130
....*....|....*
gi 2161621985 1024 TIRLVQDERKAAGLD 1038
Cdd:PTZ00427 1121 LCNHIQKMRKNLSLN 1135
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-671 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 593.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 13 SVLKYWDADGTFKKSVEQRpsgdNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPA 92
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKR----KGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 93 ELEAEKELGIENKSQIDKMGLAAFNDACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAFKQLYEKGLA 172
Cdd:pfam00133 77 EQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 173 YKGYRVLPYCPKDETPLSNHELRmdadvYQNRQDISVSVAVKMRD-EDAYAVFWTTTPWTVPGNLAIVVGPDIDYSLvqp 251
Cdd:pfam00133 157 YRGKKLVNWSPALNTALSNLEVE-----YKDVKGPSIHVAFPLADdEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI--- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 252 tegrfAGKKLYFATALLPQFAKeLGDNYTVLKELKGSDLVGRRYWPVFpyladgkatsQDGEqgedpnaFTIYPADYVET 331
Cdd:pfam00133 229 -----TGEGYILAEALLKSLYK-KGTDKKILEDFRGKELEGKEAIHPF----------VNRE-------IPIITDDYVDM 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 332 TEGTGLVHQA-VYGEDDINTLNKYGVRTVDYLDEGCRFTSLVPDYQGTRVFEANTPIVRDLrhhtgaladipeDHRAFLV 410
Cdd:pfam00133 286 EFGTGAVHIApAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELL------------TEKGLLL 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 411 QERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEINWIPDNvKDGQFGKWLSNARDWSISRNRYWGSPIP 490
Cdd:pfam00133 354 KIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIP 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 491 VWVSDDpaYPRVDVYGSLAELKRDFGrypTDDKGKINLHRPWVDSLTRpnpddptGKSTMRRISDVLDCWFESGSMPFAQ 570
Cdd:pfam00133 433 AWVSKD--TEEVVCRGELFELVAGRF---EEEGSIKWLHREAKDKLGY-------GKGTLEQDEDVLDTWFSSGSWPFST 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 571 FHYPFENKEYFEQHFPGDYVVEYIGQTRGWFYTLHIMAGALFDSPAFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNK 650
Cdd:pfam00133 501 LGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDK 580
|
650 660
....*....|....*....|.
gi 2161621985 651 YGSDAMRWFLMSSPILRGGNL 671
Cdd:pfam00133 581 YGADALRLWLANSDYGRDINL 601
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-924 |
2.10e-102 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 342.42 E-value: 2.10e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 1 MTPNPSFPDMEESVLKYWDADGTFKksveqrPSGDNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVN 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFK------PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 81 RVFGWDTHGLPAELEAEKELGIENKSQIDkMGLAAFndacRRSVLKYTNEWKDYVHRQAR----WVDFDNGYKTLDTTYM 156
Cdd:TIGR00422 75 WLPGTDHAGIATQVKVEKKLGAEGKTKHD-LGREEF----REKIWEWKEESGGTIKNQIKrlgaSLDWSRERFTMDEGLS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 157 ESVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHELrmdadVYQNRQDISVSVAVKMRDEDA-YAVFWTTTPWTVPGN 235
Cdd:TIGR00422 150 KAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEV-----EYKEVKGKLYYIRYPLANGSKdYLVVATTRPETMFGD 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 236 LAIVVGPDIDyslvqptegRFagKKLYFATALLPqfakelgdnytvlkelkgsdLVGRRywpvFPYLADgkatsqdgeqg 315
Cdd:TIGR00422 225 TAVAVHPEDE---------RY--KHLIGKKVILP--------------------LTGRK----IPIIAD----------- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 316 edpnaftiypaDYVETTEGTGLVHQAVYGE-DDINTLNKYGVRTVDYLDEGCRFTSLVPDYQGTRVFEANTPIVRDLrhh 394
Cdd:TIGR00422 259 -----------EYVDMEFGTGAVKVTPAHDfNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDL--- 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 395 tgaladipeDHRAFLVQERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLL--AHNQEINWIPDNVKDgQFGKWLS 472
Cdd:TIGR00422 325 ---------KEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALeaAEEGEIKFVPKRMEK-RYLNWLR 394
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 473 NARDWSISRNRYWGSPIPVWVSDdpayprvdvygslaelkrDFGRYptddkgkinlhrpwVDSLTRPNPDDPT---GKST 549
Cdd:TIGR00422 395 NIKDWCISRQLIWGHRIPVWYCK------------------ECGEV--------------YVAKEEPLPDDKTntgPSVE 442
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 550 MRRISDVLDCWFESGSMPFAQFHYPfENKEYFEQHFPGDYVVEYIGQTRGW-FYTLhIMAGALFDSPAFRNVICHGIVLG 628
Cdd:TIGR00422 443 LEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVTGYDIIFFWvARMI-FRSLALTGQVPFKEVYIHGLVRD 520
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 629 SDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLMSSpilrggnliVTAGgirDTVRQIMLPLWSTYYFFTLYANAAH-DGQ 707
Cdd:TIGR00422 521 EQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL---------VTPG---DDINFDWKRVESARNFLNKLWNASRfVLM 588
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 708 GLEARQVKASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDE----TA 782
Cdd:TIGR00422 589 NLSDDLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIwNDFCDWYIELVKYRLYNGNEaekkAA 668
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 783 FNTLYTALEVLCRVMAPLAPMETETIWRGL-TGGESVHLTDWPYLTEQGhkdapqtklgqvlrQDDGLVAAMEKVREVVS 861
Cdd:TIGR00422 669 RDTLYYVLDKALRLLHPFMPFITEEIWQHFkEGADSIMLQSYPVVDAEF--------------VDEEAEKAFELLKEIIV 734
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2161621985 862 ASLALRKVNQIRVRQPLSKLTIVVSD--TAAIKPCEDIFKSELNVKTVEYTTVEDAGKHDLTVIN 924
Cdd:TIGR00422 735 SIRNLKAESNIPPNAPLKVLLIYTEAetAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVELV 799
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-864 |
1.12e-99 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 337.51 E-value: 1.12e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 11 EESVLKYWDADGTFKKSVEQrpsgdNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGL 90
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDR-----NNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 91 PAELEAEKELGIENKSQIDKMGLAAfndACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAFKQLYEKG 170
Cdd:PLN02843 84 PIELKVLQSLDQEARKELTPIKLRA---KAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 171 LAYKGYRVLPYCPKDETPLSNHELRmdadvY-QNRQDISVSVAVKMRD-------------EDAYAVFWTTTPWTVPGNL 236
Cdd:PLN02843 161 YIYRGRKPVHWSPSSRTALAEAELE-----YpEGHVSKSIYVAFPVVSpsetspeeleeflPGLSLAIWTTTPWTMPANA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 237 AIVVGPDIDYSLVQPTE--------------------GRFAGKKLYFATALLPQFAKELGDNYTVLKELKGSDLVGRRY- 295
Cdd:PLN02843 236 AVAVNDKLQYSVVEVQSfsedestsggnkkkrpgnvlKEQQKLFLIVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRYi 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 296 WPVF----PYLADGkatsqdgeqgedpnaftiypaDYVETTEGTGLVHQAV-YGEDDINTLNKYGVRTVDYLDEGCRFTS 370
Cdd:PLN02843 316 HPLYnresPVVIGG---------------------DYITTESGTGLVHTAPgHGQEDYITGLKYGLPLLSPVDDAGKFTE 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 371 LVPDYQGTRVF-EANTPIVRDLRHHtGAladipedhrafLVQERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLL 449
Cdd:PLN02843 375 EAGQFSGLSVLgEGNAAVVEALDEA-GS-----------LLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAAL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 450 AHNQEINWIPDNVKDgQFGKWLSNARDWSISRNRYWGSPIPVWVSDDPAYPRVDvYGSLAELKRDFGRYPTDDKGKINLh 529
Cdd:PLN02843 443 DAIDKVKWIPAQGEN-RIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLMN-EETIAHVKSIVAQKGSDAWWYMDV- 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 530 rpwVDSLtrpnPDDPTGK-STMRRISDVLDCWFESGSMPFAqfhyPFENKEyfEQHFPGDYVVEYIGQTRGWFYTLHIMA 608
Cdd:PLN02843 520 ---EDLL----PEKYRDKaSDYEKGTDTMDVWFDSGSSWAG----VLGSRE--GLSYPADLYLEGSDQHRGWFQSSLLTS 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 609 GALFDSPAFRNVICHGIVLGSDGQKMSKHLRNYPD----VNGVFNK-----YGSDAMRWFLMS----SPILRGGNLIVTA 675
Cdd:PLN02843 587 VATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDprlvIEGGKNQkqepaYGADVLRLWVASvdytGDVLIGPQILKQM 666
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 676 GGI----RDTVRQIMLPLwstyyfftlyanaaHDgqgleARQVKASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISD 751
Cdd:PLN02843 667 SDIyrklRGTLRYLLGNL--------------HD-----WKPDNAVPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFK 727
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 752 ACDAVADYIDL-LTNWYVRNSRDRFWNEDETAF------NTLYTALEVLCRVMAPLAPMETETIWRGL------TGGESV 818
Cdd:PLN02843 728 IFQILQRFTIVdLSNFYLDVAKDRLYVGGTTSFtrrscqTVLAAHLLSLLRAIAPILPHLAEDAWQNLpfqedgSAAESV 807
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 2161621985 819 HLTDWPYLTEQ-GHKDAPQTKLGQVLRQDDGLV-AAMEKVR--EVVSASL 864
Cdd:PLN02843 808 FEAGWPTPNEEwLSFPAEDVDFWSLLLEVRDEVnKVLESARngKLIGASL 857
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
428-671 |
1.53e-93 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 301.84 E-value: 1.53e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 428 PLIYKPVSSWFVAVSKIKDRLLAHNQEINWIPDNVKDgQFGKWLSNARDWSISRNRYWGSPIPVWVSDDpayprvdvygs 507
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCED----------- 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 508 laelkrdfgryptddkgkinlhrpwvdsltrpnpddpTGKSTMRRISDVLDCWFESGSMPFAQFHYPFENKEyFEQHFPG 587
Cdd:cd00818 212 -------------------------------------CGEVLVRRVPDVLDVWFDSGSMPYAQLHYPFENED-FEELFPA 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 588 DYVVEYIGQTRGWFYTLHIMAGALFDSPAFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLMSSPIlR 667
Cdd:cd00818 254 DFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDV-Y 332
|
....
gi 2161621985 668 GGNL 671
Cdd:cd00818 333 AEDL 336
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
4-915 |
1.05e-87 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 300.57 E-value: 1.05e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 4 NPSFPDMEESVLKYWDADGTFKKsveqrpsgDNSGNEFVFF-DGPP-FANGLPHYGHLLtGYAK-DVIPRYQTMKGRRVN 80
Cdd:PRK13208 9 KYDPEELEEKWQKIWEEEGTYKF--------DPDERKPVYSiDTPPpTVSGSLHIGHVF-SYTHtDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 81 RVFGWDTHGLPAELEAEKELGIeNKSQIDKmglAAFNDACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVI 160
Cdd:PRK13208 80 FPQGWDDNGLPTERKVEKYYGI-RKDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 161 WAFKQLYEKGLAYKGYRVLPYCPKDETPLSnhelrmDADV-YQNRQDISVSVAVKmRDEDAYAVFWTTTPWTVPGNLAIV 239
Cdd:PRK13208 156 KSFLDLYKKGLIYRAEAPVLWCPRCETAIA------QAEVeYREREGKLNYIKFP-VEDGEEIEIATTRPELLPACVAVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 240 VGP-DIDYSlvqptegRFAGKklyfaTALLPQFAKELgdnytvlkelkgsdlvgrrywpvfPYLADgkatsqdgeqgedp 318
Cdd:PRK13208 229 VHPdDERYK-------HLVGK-----TAIVPLFGVEV------------------------PILAD-------------- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 319 naftiypaDYVETTEGTGLVHQAVYG-EDDINTLNKYGVRTVDYLDEGCRFTSLVPDYQGTRVFEANTPIVRDLRHhtga 397
Cdd:PRK13208 259 --------PLVDPDFGTGAVMICTFGdKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKS---- 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 398 ladipedhRAFLVQERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEINWIPDNVKDgQFGKWLSN-ARD 476
Cdd:PRK13208 327 --------GGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRV-RLENWIEGlNWD 397
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 477 WSISRNRYWGSPIPVWVSDDPAYPRVDvygslaelkrDFGRYPTDdkgkinlhrPWVDsltrpnpdDPTGKSTMRRIS-- 554
Cdd:PRK13208 398 WCISRQRYFGTPIPVWYCKDCGHPILP----------DEEDLPVD---------PTKD--------EPPGYKCPQCGSpg 450
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 555 -----DVLDCWFESGSMPFAQFHYPfENKEYFEQHFPGD-----YvvEYIgqtRGW-FYTLhIMAGALFDSPAFRNVICH 623
Cdd:PRK13208 451 fegetDVMDTWATSSITPLIVTGWE-RDEDLFEKVFPMDlrpqgH--DII---RTWlFYTI-LRAYLLTGKLPWKNIMIS 523
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 624 GIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMR-WFLMSSP---------ILRGGNLIVTAggirdtvrqimlpLWsty 693
Cdd:PRK13208 524 GMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRyWAASARLgsdtpfdekQVKIGRRLLTK-------------LW--- 587
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 694 yfftlyaNAAHDGQGLEARQVKASEVgSLSRMDRYLLARTHNLVSSVETSLDQFAISDA------------CDavaDYID 761
Cdd:PRK13208 588 -------NASRFVLHFSADPEPDKAE-VLEPLDRWILAKLAKVVEKATEALENYDFAKAleeiesffwhvfCD---DYLE 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 762 LltnwyvrnSRDRFWNEDET-----AFNTLYTALEVLCRVMAPLAPMETETIWRGLTGGeSVHLTDWPylteqghkdAPQ 836
Cdd:PRK13208 657 L--------VKSRAYGEDEEeeqksARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG-SVHRASWP---------EPD 718
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 837 TKLGqvlrqDDGLVAAMEKVREVVSaslALRKV---NQIRVRQPLSKLTIVVSDT-AAIKPCEDIFKSELNVKTVEYTTV 912
Cdd:PRK13208 719 EELI-----DEEDEELGELAKEILS---AVRKYkseAGLSLNAPLKKVEVYGPADlELLEAAEEDLKAAGNIEELELVEG 790
|
...
gi 2161621985 913 EDA 915
Cdd:PRK13208 791 DPE 793
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
40-181 |
2.28e-76 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 255.23 E-value: 2.28e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 40 EFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKELGIENKSQIDKMGLAAFNDA 119
Cdd:cd00818 2 EFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAK 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2161621985 120 CRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPY 181
Cdd:cd00818 82 CREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
4-928 |
2.08e-61 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 226.52 E-value: 2.08e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 4 NPSfpDMEESVLKYWDADGTFKksveqrpSGDNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVF 83
Cdd:PRK05729 10 DPK--EVEAKWYQKWEEKGYFK-------PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 84 GWDtH-GLPAELEAEKELGIENKSQIDkMGLAAFndacrrsvLKYTNEWKDY----VHRQARW----VDFDNGYKTLDTT 154
Cdd:PRK05729 81 GTD-HaGIATQMVVERQLAAEGKSRHD-LGREKF--------LEKVWEWKEEsggtITNQLRRlgasCDWSRERFTMDEG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 155 YMESVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHELrmdadVYQNRQDISVSVAVKMRDEDAYAVFWTTTPWTVPG 234
Cdd:PRK05729 151 LSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV-----EYKEVKGKLWHIRYPLADGSDYLVVATTRPETMLG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 235 NLAIVVGPDiD--Y-SLVqptegrfaGKKLyfataLLPqfakelgdnytvlkelkgsdLVGRRywpvFPYLADgkatsqd 311
Cdd:PRK05729 226 DTAVAVNPE-DerYkHLI--------GKTV-----ILP--------------------LVGRE----IPIIAD------- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 312 geqgedpnaftiypaDYVETTEGTGLV-----HqavygedDIN---TLNKYGVRTVDYLDEGCRFTSLVPDYQGTRVFEA 383
Cdd:PRK05729 261 ---------------EYVDPEFGTGAVkitpaH-------DPNdfeVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEA 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 384 NTPIVRDLrhhtgaladipeDHRAFLVQERSYIHSYPHCWRCGT---PLIYKpvsSWFVAVSKIKDRLLAH--NQEINWI 458
Cdd:PRK05729 319 RKAIVADL------------EELGLLVKIEPHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALEAveNGEIKFV 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 459 PDNvkdgqFGK----WLSNARDWSISRNRYWGSPIPVWvsddpayprvdvygslaelkrdfgrypTDDKGKInlhrpWVD 534
Cdd:PRK05729 384 PER-----WEKtyfhWMENIQDWCISRQLWWGHRIPAW---------------------------YDEDGEV-----YVG 426
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 535 sltrPNPDDPTGKSTMRRISDVLDCWFESGSMPFAQFHYPfENKEYFEQHFPGDYVVeyigqTrG------W-----FYT 603
Cdd:PRK05729 427 ----REEPEAREKALLTQDEDVLDTWFSSALWPFSTLGWP-EKTEDLKRFYPTSVLV-----T-GfdiiffWvarmiMMG 495
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 604 LHIMagalfDSPAFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLMSSpilrggnliVTAGgirdtvR 683
Cdd:PRK05729 496 LHFT-----GQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAAL---------ASPG------R 555
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 684 QIML-------------PLWstyyfftlyaNAA----HDGQGLEARQVKASEVGSLSrmDRYLLARTHNLVSSVETSLDQ 746
Cdd:PRK05729 556 DIRFdeervegyrnfanKLW----------NASrfvlMNLEGADVGELPDPEELSLA--DRWILSRLNRTVAEVTEALDK 623
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 747 FAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDE-TAFNTLYTALEVLCRVMAPLAPMETETIWRGLTG---GESVHLT 821
Cdd:PRK05729 624 YRFDEAARALYEFIwNEFCDWYLELAKPVLQEAAKrATRATLAYVLEQILRLLHPFMPFITEELWQKLAPlgiEESIMLA 703
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 822 DWPYLTEQghkdapqtklgqvlrQDDGLVAAMEKVREVVSASLALRKVNQIRVRQPLsKLTIVVSD---TAAIKPCEDIF 898
Cdd:PRK05729 704 PWPEADEA---------------IDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKL-PLLLKGADaedRARLEANEAYI 767
|
970 980 990
....*....|....*....|....*....|..
gi 2161621985 899 KSELNVKTVEYTTVEDAGKHD--LTVINELKV 928
Cdd:PRK05729 768 KRLARLESLEILADDEEAPEGaaSAVVGGAEL 799
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
677-864 |
4.69e-61 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 206.25 E-value: 4.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 677 GIRDTVRQIMLPLWSTYYFFTLYANAAHDGQGlearqVKASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAV 756
Cdd:cd07961 5 GVREVVRKVLLPLWNAYRFFVTYANLDGFDPG-----KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 757 ADYIDLLTNWYVRNSRDRFWNEDET-----AFNTLYTALEVLCRVMAPLAPMETETIWRGLTGG-----ESVHLTDWPYL 826
Cdd:cd07961 80 LEFIDELTNWYIRRNRKRFWGEEGDddklaAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRElgdapESVHLLDWPEV 159
|
170 180 190
....*....|....*....|....*....|....*...
gi 2161621985 827 TEqghkdapqtklgqvLRQDDGLVAAMEKVREVVSASL 864
Cdd:cd07961 160 DE--------------SLIDEELEEAMELVREIVELGR 183
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
4-928 |
5.09e-58 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 216.07 E-value: 5.09e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 4 NPSfpDMEESVLKYWDADGTFKksveqrPSGDNsgnefvffDGPPFANGLP--------HYGHLLTGYAKDVIPRYQTMK 75
Cdd:COG0525 8 DPK--EVEAKWYQYWEENGYFK------ADPDS--------DKEPFTIVIPppnvtgslHMGHALNNTLQDILIRYKRMQ 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 76 GRRVNRVFGWDtH-GLPAELEAEKELGIENKSQIDkMGLAAFndacrrsvLKYTNEWKDY----VHRQARW----VDFDN 146
Cdd:COG0525 72 GYNTLWQPGTD-HaGIATQAVVERQLAEEGKSRHD-LGREKF--------LERVWEWKEEsggtITNQLRRlgasCDWSR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 147 GYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSnhelrmDADVyqnrqdISVSVAVKM-------RDED 219
Cdd:COG0525 142 ERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALS------DLEV------EHEEVKGHLwhiryplADGS 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 220 AYAVFWTTTPWTVPGNLAIVVGPDiD--Y-SLVqptegrfaGKklyfaTALLPqfakelgdnytvlkelkgsdLVGRRyw 296
Cdd:COG0525 210 GYIVVATTRPETMLGDTAVAVHPE-DerYkHLI--------GK-----TVILP--------------------LVGRE-- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 297 pvFPYLADgkatsqdgeqgedpnaftiypaDYVETTEGTGLV-----HqavygedDINtlnkygvrtvDY---------- 361
Cdd:COG0525 254 --IPIIAD----------------------EYVDPEFGTGAVkitpaH-------DPN----------DFevgkrhnlpm 292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 362 ---LDEGCRFTSLVPDYQGTRVFEANTPIVRDLrhhtgaladipeDHRAFLVQERSYIHSYPHCWRCGT---PLIykpvs 435
Cdd:COG0525 293 iniLDEDGTINENAGKYRGLDRFEARKAIVADL------------EELGLLVKVEPHKHSVGHSDRSGTviePYL----- 355
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 436 S--WFVAVSKIKDRLLAH--NQEINWIPDNvkdgqFGK----WLSNARDWSISRNRYWGSPIPVWvsddpayprvdvygs 507
Cdd:COG0525 356 SdqWFVKMKPLAKPAIEAveDGEIKFVPER-----WEKtyfhWMENIRDWCISRQLWWGHRIPAW--------------- 415
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 508 laelkrdfgrypTDDKGKInlhrpWVdSLTRPNPDDPTGKSTMRRISDVLDCWFESGSMPFAQFHYPFENKEyFEQHFPG 587
Cdd:COG0525 416 ------------YCPDGEV-----YV-ARTEPEACAKAGSVNLTQDEDVLDTWFSSALWPFSTLGWPEKTED-LKYFYPT 476
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 588 DYVVeyigqTrG------W-----FYTLHIMagalfDSPAFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAM 656
Cdd:COG0525 477 SVLV-----T-GfdiiffWvarmiMMGLHFT-----GEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADAL 545
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 657 RWFLMSSpilrggnliVTAGgiRDtvrqIMLP-------------LWstyyfftlyaNAA----HDGQGLEARQVKASEv 719
Cdd:COG0525 546 RFTLAAL---------ASPG--RD----IKFDeervegyrnfankLW----------NASrfvlMNLEGFDPGLDPDPE- 599
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 720 gSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDE----TAFNTLYTALEVLC 794
Cdd:COG0525 600 -ELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYLELAKPRLYGGDEaakrETRATLVYVLEQIL 678
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 795 RVMAPLAPMETETIWRGLT---GGESVHLTDWPYLTEQghkdapqtklgqvlRQDDGLVAAMEKVREVVSASLALRKVNQ 871
Cdd:COG0525 679 RLLHPFMPFITEEIWQKLPprkEGESIMLAPWPEADEE--------------LIDEEAEAEFEWLKEVISAIRNIRAEMN 744
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 872 IRVRQPLsKLTIVVSD---TAAIKPCEDIFKSELNVKTVEYTTVEDAGKHDLTVINELKV 928
Cdd:COG0525 745 IPPSKKL-PLLLKGADeadRARLEENAAYIKRLARLEEITILVDEKPEGAASAVVGGAEV 803
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
45-824 |
8.89e-48 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 185.97 E-value: 8.89e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 45 DGPPFANGLP--------HYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKEL-GIENKSQIDkMGLAA 115
Cdd:PRK14900 46 TRPPFSIVLPppnvtgslHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKELkKTEKKSRHD-LGREA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 116 FndacrrsvLKYTNEWKD-YVHR---QARWV----DFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPYCPKDET 187
Cdd:PRK14900 125 F--------LERVWAWKEqYGSRigeQHKALgaslDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 188 PLSNHELRMDadvyQNRQDISVSVAVKMRDEDAYAVFWTTTPWTVPGNLAIVVGPDidyslvQPTEGRFAGKKLyfataL 267
Cdd:PRK14900 197 ALSDLEVEHE----EAHQGELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPL------DPRYMALHGKKV-----R 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 268 LPqfakelgdnytvlkelkgsdLVGRRywpvFPYLADgkatsqdgeqgedpnaftiypADYVETTEGTGLVH-QAVYGED 346
Cdd:PRK14900 262 HP--------------------ITGRT----FPIVAD---------------------AILVDPKFGTGAVKvTPAHDFN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 347 DINTLNKYGVRTVDYLDEGCRFTSLVPDYQGTRVFEANTPIVRDLRHhtgaladipedhRAFLVQERSYIHSYPHCWRCG 426
Cdd:PRK14900 297 DFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAE------------QGLDRGAKPHVLPLGRCQRSA 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 427 TplIYKPVSS--WFVAVSKI-KDRLLAHNQ-EINWIPDNVKDGQFGkWLSNARDWSISRNRYWGSPIPVWvsddpayprv 502
Cdd:PRK14900 365 T--ILEPLLSdqWYVRIEPLaRPAIEAVEQgRTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAW---------- 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 503 dvygslaelkrdfgrYPTDdkGKINLHRpwvdslTRPNPDDPTGKSTMRRISDVLDCWFESGSMPFAQFHYPfENKEYFE 582
Cdd:PRK14900 432 ---------------YCPD--GHVTVAR------ETPEACSTCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLR 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 583 QHFPGDyVVEyIGQTRGWFYTLHIMAGALF---DSPaFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWF 659
Cdd:PRK14900 488 TFYPTS-VME-TGHDIIFFWVARMMMMGLHfmgEVP-FRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFT 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 660 LMSspILRGGNLIVTAGGIRDTVRQIMLPLWSTYYFftlyanAAHDGQGLEARQVKASEVgSLSRMDRYLLARTHNLVSS 739
Cdd:PRK14900 565 LAA--LTAQGRDIKLAKERIEGYRAFANKLWNASRF------ALMNLSGYQERGEDPARL-ARTPADRWILARLQRAVNE 635
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 740 VETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDE----TAFNTLYTALEVLCRVMAPLAPMETETIWRGLTG 814
Cdd:PRK14900 636 TVEALEAFRFNDAANAVYAFVwHELCDWYIELAKEALASEDPearrSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRA 715
|
810
....*....|
gi 2161621985 815 geSVHLTDWP 824
Cdd:PRK14900 716 --QVGASAWA 723
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-824 |
2.37e-46 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 180.91 E-value: 2.37e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 11 EESVLKYWDADGTFKksveqrPSGDNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGL 90
Cdd:PLN02943 66 EERIYNWWESQGYFK------PNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 91 PAELEAEKELGIENKSQIDkMGLAAFNDACRRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAFKQLYEKG 170
Cdd:PLN02943 140 ATQLVVEKMLASEGIKRTD-LGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 171 LAYKGYRVLPYCPKDETPLSNHELRMDAD---VYQnrqdISVSVAVKMRDedaYAVFWTTTPWTVPGNLAIVVGPDID-Y 246
Cdd:PLN02943 219 LIYQGSYMVNWSPNLQTAVSDLEVEYSEEpgtLYY----IKYRVAGGSED---FLTIATTRPETLFGDVAIAVNPEDDrY 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 247 SlvqptegRFAGKklyfaTALLPqfakelgdnytvlkelkgsdLVGRRYWPVfpyLADgkatsqdgeqgedpnaftiypa 326
Cdd:PLN02943 292 S-------KYIGK-----MAIVP--------------------MTYGRHVPI---IAD---------------------- 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 327 DYVETTEGTGlVHQAVYGED--DINTLNKYGVRTVDYLDEgcrfTSLVPDYQGTRVFEANTPIVRDLRHhTGaLAdiped 404
Cdd:PLN02943 315 RYVDKDFGTG-VLKISPGHDhnDYLLARKLGLPILNVMNK----DGTLNEVAGLYWFEAREKLWSDLEE-TG-LA----- 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 405 hraflVQERSYIHSYPHCWRCGT---PLIYKpvsSWFVAVSKIKDRLL--AHNQEINWIPDNVKDgQFGKWLSNARDWSI 479
Cdd:PLN02943 383 -----VKKEPHTLRVPRSQRGGEviePLVSK---QWFVTMEPLAEKALkaVENGELTIIPERFEK-IYNHWLSNIKDWCI 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 480 SRNRYWGSPIPVWVsddpayprvdVYGSLAELKRDFGRYPTDDKGKINlhrpwvdsltrpnpdDPTGKST-MRRISDVLD 558
Cdd:PLN02943 454 SRQLWWGHRIPVWY----------IVGKDCEEDYIVARSAEEALEKAR---------------EKYGKDVeIYQDPDVLD 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 559 CWFESGSMPFAQFHYPFENKEYFEQHFPGDyVVEyIGQTRGWFYTLH-IMAGALFD-SPAFRNVICHGIVLGSDGQKMSK 636
Cdd:PLN02943 509 TWFSSALWPFSTLGWPDVSAEDFKKFYPTT-VLE-TGHDILFFWVARmVMMGIEFTgTVPFSYVYLHGLIRDSQGRKMSK 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 637 HLRNYPDVNGVFNKYGSDAMRWFLMSSPILRGGNLIVTaggiRDTVRQIML-PLWSTYYFFTLYANAAHDGQGLEA-RQV 714
Cdd:PLN02943 587 TLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTE----RLTSNKAFTnKLWNAGKFVLQNLPSQSDTSAWEHiLAC 662
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 715 KASEVGSLSRM---DRYLLARTHNLVSSVETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFW-NEDETAFNT---- 785
Cdd:PLN02943 663 KFDKEESLLSLplpECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFwSDFADWYIEASKTRLYhSGDNSALSRaqav 742
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 2161621985 786 LYTALEVLCRVMAPLAPMETETIWRGLTG-GESVHLTDWP 824
Cdd:PLN02943 743 LLYVFENILKLLHPFMPFVTEELWQALPYrKEALIVSPWP 782
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
422-663 |
1.10e-43 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 163.57 E-value: 1.10e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 422 CWRCGTPLIYKPVSSWFVAVSKIKDRLL--AHNQEINWIPDNVKDgQFGKWLSNARDWSISRNRYWGSPIPVWVSDDPAY 499
Cdd:cd00817 156 CSRSGDVIEPLLKPQWFVKVKDLAKKALeaVKEGDIKFVPERMEK-RYENWLENIRDWCISRQLWWGHRIPAWYCKDGGH 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 500 PRVDvygslaelkrdfgryPTDDKgkinlhrpwVDSLTRPNPDDPTGKSTMRRISDVLDCWFESGSMPFAQFHYPfENKE 579
Cdd:cd00817 235 WVVA---------------REEDE---------AIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWP-EETK 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 580 YFEQHFPGDYVVEyiGQ--TRGW-FYTLhIMAGALFDSPAFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAM 656
Cdd:cd00817 290 DLKKFYPTSLLVT--GHdiIFFWvARMI-MRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADAL 366
|
....*..
gi 2161621985 657 RWFLMSS 663
Cdd:cd00817 367 RFTLASA 373
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
429-663 |
2.69e-39 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 148.72 E-value: 2.69e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 429 LIYK------PVSSWFVAVSKIKDRLLAHNQEINWIPDNVKDgQFGKWLSNARDWSISRNRYWGSPIPvwvsddpayprv 502
Cdd:cd00668 128 LIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVKN-RMEAWLESLLDWAISRQRYWGTPLP------------ 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 503 dvygslaelkrdfgryptddkgkinlhrpwvdsltrpnpddptgkstmrriSDVLDCWFESGSMPFAQFHYPFENKEyFE 582
Cdd:cd00668 195 ---------------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEW-FK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 583 QHFPGDYVVEYIGQTRGWFYTLHIMAGALFDSPAFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLMS 662
Cdd:cd00668 223 DSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTS 302
|
.
gi 2161621985 663 S 663
Cdd:cd00668 303 L 303
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
41-178 |
1.93e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 140.25 E-value: 1.93e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 41 FVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKELGIENKSQIdkmgLAAFNDAC 120
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFREDP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2161621985 121 RRSVLKYTNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRV 178
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
9-824 |
5.81e-35 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 144.76 E-value: 5.81e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 9 DMEESVLKYWDADGTFKKSveQRPSGDNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTH 88
Cdd:PTZ00419 32 EVESGWYEWWEKSGFFKPA--EDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 89 GLPAELEAEKELGI-ENKSQIDkMGLAAFndacrrsvLKYTNEWKDY----VHRQARW----VDFDNGYKTLDTTYMESV 159
Cdd:PTZ00419 110 GIATQVVVEKKLMKeENKTRHD-LGREEF--------LKKVWEWKDKhgnnICNQLRRlgssLDWSREVFTMDEQRSKAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 160 IWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHEL---------RMDADVYQNRQDISV--SVAVKMRD-EDAYAVFWTT 227
Cdd:PTZ00419 181 KEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVefeeiekptKITIPGYDKKVEVGVlwHFAYPLEDsGQEEIVVATT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 228 TPWTVPGNLAIVVGPDidyslvqptEGRFAgkklyfatallpqfakelgdnytvlkelkgsDLVGRRYwpVFPYLADGKa 307
Cdd:PTZ00419 261 RIETMLGDVAVAVHPK---------DERYK-------------------------------KLHGKEL--IHPFIPDRK- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 308 tsqdgeqgedpnafTIYPAD--YVETTEGTGLV-----HQavygEDDINTLNKYGVRTVDYLDEGCRFTSLVPDYQGTRV 380
Cdd:PTZ00419 298 --------------IPIIADdeLVDMEFGTGAVkitpaHD----PNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 381 FEANTPIVRDLRhhtgaladipedHRAFLVQERSYIHSYPHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAH--NQEINWI 458
Cdd:PTZ00419 360 FDCRRKIEEELK------------EMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKII 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 459 PDNVKDGQFgKWLSNARDWSISRNRYWGSPIpvwvsddPAYpRVDVYGSLAElkrdfgRYPTDdkgkinlhrPWV----- 533
Cdd:PTZ00419 428 PSSHENVWY-HWLENIQDWCISRQLWWGHRI-------PAY-RVISKGPETD------PSDEE---------PWVvarse 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 534 -DSLTR-----PNPDDptgKSTMRRISDVLDCWFESGSMPFAQFHYPfENKEYFEQHFPGDyvveyIGQTrG------WF 601
Cdd:PTZ00419 484 eEALEKakkkfGLSEE---DFELEQDEDVLDTWFSSGLFPFSTLGWP-DQTDDLQRFFPTS-----LLET-GsdilffWV 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 602 YTLHIMAGALFDSPAFRNVICHGIVLGSDGQKMSKHLRNYPD----VNGV------------------------------ 647
Cdd:PTZ00419 554 ARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDplevIEGIslqdlnqklyegnlpekeikraielqkkef 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 648 ---FNKYGSDAMRWFLMSSPIL-RGGNLivtagGIRDTV--RQIMLPLWSTYYFFTLYANAAHDGQGLEarQVKASEVGS 721
Cdd:PTZ00419 634 pngIPECGTDALRFGLLAYTQQgRNINL-----DINRVVgyRHFCNKLWNAVKFALMKLLKDFNLPNST--LFKPNNVES 706
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 722 LSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADY-IDLLTNWYVRNSRDRFWNED-----ETAFNTLYTALEVLCR 795
Cdd:PTZ00419 707 LPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFwLYELCDVYLELIKPRLSKQSdgerkQHAQDVLHTVLDIGLR 786
|
890 900 910
....*....|....*....|....*....|...
gi 2161621985 796 VMAPLAPMETETIWRGL----TGGESVHLTDWP 824
Cdd:PTZ00419 787 LLHPMMPFITEELYQRLpnylRKSESISIAKYP 819
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-824 |
6.57e-31 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 131.53 E-value: 6.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 54 PHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLP----AELEAEKElgienKSQIDKMglaafndacrRSVLKYTN 129
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERIARGD-----PETIELY----------KSLYGIPE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 130 E----------WKDYVHRQARwVDFDN-GY--------KTLDTTYMESVIWAFKQLYEKGLAYKG-YRVLpYCPKDETPL 189
Cdd:PRK12300 66 EelekfkdpeyIVEYFSEEAK-EDMKRiGYsidwrrefTTTDPEYSKFIEWQFRKLKEKGLIVKGsHPVR-YCPNDNNPV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 190 SNHELRMDADVyqnrqDISVSVAVK-MRDEDAYAVFWTTTPWTVPGNLAIVVGPDIDYSLVQPTEGRF-----AGKKLYF 263
Cdd:PRK12300 144 GDHDLLDGEEP-----EIVEYTLIKfEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWivskeAAEKLSF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 264 atallpQfakelGDNYTVLKELKGSDLVGRRYW-PVfpylaDGKatsqdgeqgEDPnaftIYPADYVETTEGTGLV---- 338
Cdd:PRK12300 219 ------Q-----DRDVEIIEEIKGSELIGKKVKnPV-----TGK---------EVP----ILPADFVDPDNGTGVVmsvp 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 339 -HqAVY---------------------------GEDDI---------NTLNKYGVRTVDYLDEGCR-------FTSLVPD 374
Cdd:PRK12300 270 aH-APYdyvalrdlkknkelldviepiplieveGYGEFpakevveklGIKSQEDPELEEATKEVYRaefhkgvLKENTGE 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 375 YQGTRVFEANTPIVRDLRhhtgaladipEDHRAFLVQERSYIHSYphCwRCGTPLIYKPVS-SWFVAVSKIKDRLLAHNQ 453
Cdd:PRK12300 349 YAGKPVREAREKITKDLI----------EKGIADIMYEFSNRPVY--C-RCGTECVVKVVKdQWFIDYSDPEWKELAHKA 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 454 --EINWIPDNVKDgQFGKWLSNARDWSISRNRYWGSPIPV---WV----SDDPAYP-------RVDVYGSLAE-LKRDFG 516
Cdd:PRK12300 416 ldNMEIIPEEYRK-EFENTIDWLKDRACARRRGLGTRLPWdeeWIieslSDSTIYMayytiahKIREYGIKPEqLTPEFF 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 517 RYPTDDKGkinlhrpwvdsltrpNPDDPTGKS--------TMRRisdvldcWFEsgsmpfaqFHYP----FENKEYFEQH 584
Cdd:PRK12300 495 DYVFLGKG---------------DPEEVSKKTgipkeileEMRE-------EFL--------YWYPvdwrHSGKDLIPNH 544
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 585 FPgdyvveyigqtrgwFYTLHIMagALFDS---PafRNVICHGIVLgSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLM 661
Cdd:PRK12300 545 LT--------------FFIFNHV--AIFPEekwP--RGIVVNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLT 605
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 662 SSpilrggnlivtAG----------GIRDTVRQIMlplwsTYYFFTlyanaahdgqgleARQVKASEVGSLSRMDRYLLA 731
Cdd:PRK12300 606 SS-----------AEllqdadwrekEVESVRRQLE-----RFYELA-------------KELIEIGGEEELRFIDKWLLS 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 732 RTHNLVSSVETSLDQFAISDAcdAVADYIDLLT--NWYVRNSRDRfwNEDetafnTLYTALEVLCRVMAPLAPMETETIW 809
Cdd:PRK12300 657 RLNRIIKETTEAMESFQTRDA--VQEAFYELLNdlRWYLRRVGEA--NNK-----VLREVLEIWIRLLAPFTPHLAEELW 727
|
890
....*....|....*
gi 2161621985 810 RGLTGGESVHLTDWP 824
Cdd:PRK12300 728 HKLGGEGFVSLEKWP 742
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
10-665 |
6.99e-30 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 127.95 E-value: 6.99e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 10 MEESVLKYWDADGTFKksveqrPSGDNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHG 89
Cdd:TIGR00396 6 IEEKWQQKWDENKTFK------VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 90 LPAELEAEK---------ELGIEN-KSQIDKMGLaafndacrrsvlkytnewkDYvhrqarwvDFDNGYKTLDTTYMESV 159
Cdd:TIGR00396 80 LPAENAAIKrgihpakwtYENIANmKKQLQALGF-------------------SY--------DWDREIATCDPEYYKWT 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 160 IWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHEL-------RMDADVYQ------------------------------ 202
Cdd:TIGR00396 133 QWIFLELFEKGLAYVKEADVNWCPNDGTVLANEQVdsdgrswRGDTPVEKkelkqwflkitayaeellndleeldhwpes 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 203 ----NRQDISVSVAV----KMRDE-DAYAVFwTTTPWTVPGNLAIVVGPDidYSLVQPtegrfagkklyfATALLPQFAK 273
Cdd:TIGR00396 213 vkemQRNWIGKSEGVeitfKIADHdEKITVF-TTRPDTIFGVTYLALAPE--HPLVEK------------AAENNPKVAA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 274 elgdnyTVLKELKGSDLVgrrywpvfpyladgKATSQDGEQGEDPNAFTIYP----------ADYVETTEGTGLVhQAVY 343
Cdd:TIGR00396 278 ------FIKKILNKTVAE--------------RTKATKEKKGVDTGIKAIHPltgekipiwvANYVLMEYGTGAV-MGVP 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 344 GEDDintlnkygvrtvdyldegcrftslvPDYQGTRVFEANTPIVrdlrhhtgalADIPEDHRAFLVQERSYIHSYphcw 423
Cdd:TIGR00396 337 AHDE-------------------------RDFEFAQKYGLPIKPV----------IDPAEKDLSLTAAYTEDGVLV---- 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 424 rcgtpliykpVSSWFVAVSKIKdrllAHNQEINWIPDNvkdgQFGKWLSN--ARDWSISRNRYWGSPIPVWVSDDP---A 498
Cdd:TIGR00396 378 ----------NSGEFNGLNSSE----ARNAIIDMLEKE----GKGKRKVNyrLRDWGFSRQRYWGEPIPIIHCEDGgvvP 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 499 YPRVDVYGSLAELKrdfgRYPTDDKGKINLHRPWVdsltrpNPDDPTGKSTMRRISDVLDCWFESgSMPFAQF---HYP- 574
Cdd:TIGR00396 440 VPEEDLPVILPEDV----VYDGDGGSPLSRIPEWV------NVTCPSCGKPALRETDTMDTFAGS-SWYYLRYldpKNTd 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 575 -FENKEYFEQHFPGDyvvEYIGQTRgwFYTLHIM-----------AGALFDSPAFRNVICHGIVLG-------------- 628
Cdd:TIGR00396 509 gPFDKEKAEYWLPVD---LYIGGIE--HAILHLLyarffhkflrdIGYVNTKEPFKKLINQGMVLGfyyppngkvpadvl 583
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*
gi 2161621985 629 -----------------SDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLM-SSPI 665
Cdd:TIGR00396 584 terdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMfMGPI 638
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
895-1074 |
1.54e-25 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 104.86 E-value: 1.54e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 895 EDIFKSELNVKTVEYttVEDAGKHdltVINELKVNARAAGPRLGKQvqlaIKAAKTGSWKKDQSgavTVQTPQGD----I 970
Cdd:pfam19302 1 EDIIKEELNVKEVEF--GADESEL---VEYSAKPNFPVLGKELGKL----MKAAAKEIASLNQM---EIQKILDGgtltI 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 971 ALEPGEYELNSrveeahasdtDSIVSAPLPTGGF---------VLLDTELTDDLLAEGYARDTIRLVQDERKAAGLDISD 1041
Cdd:pfam19302 69 DVDGEEIELTS----------EDLLVTRQGKEGLavanegtltVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTD 138
|
170 180 190
....*....|....*....|....*....|...
gi 2161621985 1042 RINLTLLVPPADRAKVEQFADLIAQETLAVSYD 1074
Cdd:pfam19302 139 RINLYVSGNEMLEAAIEKFEDYIKKETLAVEII 171
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
726-881 |
4.05e-24 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 99.01 E-value: 4.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 726 DRYLLARTHNLVSSVETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDE--TAFNTLYTALEVLCRVMAPLAP 802
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPdsRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2161621985 803 METETIWRgltgGESVHLTDWPylteqghKDAPQtklgqvlrQDDGLVAAMEKVREVVSASLALRKVNQIRVRQPLSKL 881
Cdd:pfam08264 81 FITEELWQ----KESIHLAPWP-------EDAEL--------EEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVV 140
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
47-193 |
4.06e-24 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 105.79 E-value: 4.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 47 PPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKELGIENKSQIDkMGLAAFndacRRSVLK 126
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHD-LGREEF----LEKCWE 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2161621985 127 YTNEWKDYVHRQARW----VDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHE 193
Cdd:cd00817 84 WKEESGGKIREQLKRlgasVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE 154
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-829 |
2.98e-23 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 106.91 E-value: 2.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 4 NPSfpDMEESVLKYWDADGTFKKSveqrpsGDNSGNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVF 83
Cdd:PLN02381 101 SPS--AVEKSWYAWWEKSGYFGAD------AKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 84 GWDTHGLPAELEAEKELGIENKSQIDKMGLAAFndacRRSVLKYTNEWKDYVHRQARWV----DFDNGYKTLDTTYMESV 159
Cdd:PLN02381 173 GVDHAGIATQVVVEKKLMRERHLTRHDIGREEF----VSEVWKWKDEYGGTILNQLRRLgaslDWSRECFTMDEQRSKAV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 160 IWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHELR---------MDADVYQNRQDISV--SVAVKMRDEDAYAVFWTTT 228
Cdd:PLN02381 249 TEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDyidikertlLKVPGYDKPVEFGVltSFAYPLEGGLGEIVVATTR 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 229 PWTVPGNLAIVVGPDidyslvqptEGRFagKKLYFATALLPqfakelgdnytvlkelkgsdLVGRRywpvFPYLADgkat 308
Cdd:PLN02381 329 IETMLGDTAIAIHPD---------DERY--KHLHGKFAVHP--------------------FNGRK----LPIICD---- 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 309 sqdgeqgedpnaftiypADYVETTEGTGLVH-QAVYGEDDINTLNKYGVRTVD-YLDEGCRFTSLVPDYQGTRVFEANTP 386
Cdd:PLN02381 370 -----------------AILVDPNFGTGAVKiTPAHDPNDFEVGKRHNLEFINiFTDDGKINSNGGSEFAGMPRFAAREA 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 387 IVRDLRHHtGALADIPEDHRAFLVQERSYihsyphcwRCGTPLIyKPvsSWFVAVSKIKDRLL-----AHNQEINWIPDN 461
Cdd:PLN02381 433 VIEALQKK-GLYRGAKNNEMRLGLCSRTN--------DVVEPMI-KP--QWFVNCSSMAKQALdaaidGENKKLEFIPKQ 500
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 462 VkDGQFGKWLSNARDWSISRNRYWGSPIPVWvsddpayprvdvYGSLAE-LKRDFGRYptddkgkinlHRPWV------D 534
Cdd:PLN02381 501 Y-LAEWKRWLENIRDWCISRQLWWGHRIPAW------------YVTLEDdQLKELGSY----------NDHWVvarnesD 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 535 SLTRPNPDDPTGKSTMRRISDVLDCWFESGSMPFAQFHYPfENKEYFEQHFPGDyVVEyIGQTRGWFYTLH-IMAGALF- 612
Cdd:PLN02381 558 ALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTS-VLE-TGHDILFFWVARmVMMGMQLg 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 613 -DSPaFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMRwflmssPILRGGNL------IVTAGGIRDTVRQI 685
Cdd:PLN02381 635 gDVP-FRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLH------KRLEEGNLdpkelvVAKEGQKKDFPNGI 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 686 MLPLWSTYYFFTLYANAAHDGQGLEARQVkaseVG--------------SLSRMD------------------RYLLART 733
Cdd:PLN02381 708 AECGTDALRFALVSYTAQSDKINLDILRV----VGyrqwcnklwnavrfAMSKLGddytppatlsvetmpfscKWILSVL 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 734 HNLVSSVETSLDQFAISDACDAVAD---------YIDLLTNWYVRNSRDrFWNEDETAFNTLYTALEVLCRVMAPLAPME 804
Cdd:PLN02381 784 NKAISKTVSSLDAYEFSDAASTVYSwwqyqfcdvFIEAIKPYFAGDNPE-FASERAAAQDTLWICLDTGLRLLHPFMPFV 862
|
890 900 910
....*....|....*....|....*....|.
gi 2161621985 805 TETIW------RGLTGGESVHLTDWPYLTEQ 829
Cdd:PLN02381 863 TEELWqrlpqpKDHTRKDSIMISEYPSAVEA 893
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
48-195 |
2.42e-18 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 87.20 E-value: 2.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 48 PFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKElGIENKSQIDKMGlAAFNDacrrsvlky 127
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEE-GVTPQELCDKYH-EIFKD--------- 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2161621985 128 TNEWKDyvhrqarwVDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSnhELR 195
Cdd:cd00814 78 LFKWLN--------ISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP--EWR 135
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
48-196 |
9.32e-17 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 83.49 E-value: 9.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 48 PFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKElGIenksqidkmglaafndacrrSVLKY 127
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKE-GI--------------------TPEEL 66
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2161621985 128 TNEWKDYVHRQARW--VDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHELRM 196
Cdd:pfam09334 67 VDRYHEIHREDFKKfnISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEG 137
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
7-824 |
3.80e-15 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 80.64 E-value: 3.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 7 FPDMEESVLKYWDADGTFKKsveqrPSG-DNSGNEFVFFDGPPFANGLP-HYGHLLtGY-AKDVIPRYQTMKGRRVNRVF 83
Cdd:PLN02563 82 FHEIEPKWQRYWEENRTFRT-----PDDvDTSKPKFYVLDMFPYPSGAGlHVGHPE-GYtATDILARYKRMQGYNVLHPM 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 84 GWDTHGLPAELEAeKELGIENKSQIDKmglaafNDACRRSVLK---YTNEWkdyvhrqarwvdfDNGYKTLDTTYMESVI 160
Cdd:PLN02563 156 GWDAFGLPAEQYA-IETGTHPKITTLK------NIARFRSQLKslgFSYDW-------------DREISTTEPEYYKWTQ 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 161 WAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHEL-----------------------------RMDADV----------Y 201
Cdd:PLN02563 216 WIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitayadRLLEDLddldwpesikE 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 202 QNRQDISVSVAVKM---------RDEDAYAVFWTTTPWTVPGNLAIVVGPdiDYSLVQptegrfagkklYFATALlpqfA 272
Cdd:PLN02563 296 MQRNWIGRSEGAELdfsvldgegKERDEKITVYTTRPDTLFGATYLVVAP--EHPLLS-----------SLTTAE----Q 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 273 KELGDNYTVLKELKgSDLvgRRywpvfPYLADGKATSQDGEQGEDP---NAFTIYPADYVETTEGTGLVhQAVYGEDDin 349
Cdd:PLN02563 359 KEAVEEYVDAASRK-SDL--ER-----TELQKEKTGVFTGSYAINPatgEAIPIWVADYVLGSYGTGAI-MAVPAHDT-- 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 350 tlnkygvrtvdyldegcrftslvPDYQGTRVFeaNTPIVRDLRHHTGALADipedhraflvQERSYIHSYPHCWRCGTPL 429
Cdd:PLN02563 428 -----------------------RDFEFAQKF--DLPIKWVVKPADGNEDD----------AEKAYTGEGVIVNSSSSGL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 430 IYKPVSSwFVAVSKIkdrllahnqeINWIPDNVKDGQfgKWLSNARDWSISRNRYWGSPIPVWVSDDP----AYPRVDVY 505
Cdd:PLN02563 473 DINGLSS-KEAAKKV----------IEWLEETGNGKK--KVNYKLRDWLFARQRYWGEPIPVVFLEDSgepvPVPESDLP 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 506 GSLAELKrDFGryPTDD-KGKINLHRPWVDSLtrpnpDDPTGKSTMRRISDVL----DCWFesgsmpFAQFHYPFENKEY 580
Cdd:PLN02563 540 LTLPELD-DFT--PTGTgEPPLAKAVSWVNTV-----DPSSGKPARRETNTMPqwagSCWY------YLRFMDPKNSNAL 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 581 F-----EQHFPGD-YV------VEYIGQTRGWFYTLHIMaGALFDSPAFRNVICHGIVLG---------SDGQ------- 632
Cdd:PLN02563 606 VdkekeKYWMPVDlYVggaehaVLHLLYARFWHKVLYDI-GVVSTKEPFQCLVNQGMILGeveytafkdSDGEyvsadta 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 633 --------------------------------------KMSKHLRNYPDVNGVFNKYGSDAMRWFLMSSPILRGGNLIVT 674
Cdd:PLN02563 685 drlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWST 764
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 675 aGGIRDTVRQimlpLWSTYYFFtlyanaahDGQGLEARQVKASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACD 754
Cdd:PLN02563 765 -SGVEGVHRF----LGRTWRLV--------VGAPLPDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAIS 831
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 755 AVADYIDLLTNWyvrNSRDRfwnedetafntlyTALEVLCRVMAPLAPMETETIWRGLTGGESVHLTDWP 824
Cdd:PLN02563 832 AMMEFTNAAYKW---DKVPR-------------EAIEPFVLLLSPYAPHLAEELWFRLGHSNSLAYEPWP 885
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
48-189 |
5.59e-15 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 79.39 E-value: 5.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 48 PFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKElGIENKSQIDKMGlAAFNDAcrrsvlky 127
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKE-GITPQELVDRIH-AEFKEL-------- 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2161621985 128 tneWKDYvHrqarwVDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKG-YRVLpYCPKDETPL 189
Cdd:COG0143 80 ---FEKL-G-----ISFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGeYEGW-YCPECERFL 132
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
709-812 |
1.68e-14 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 71.43 E-value: 1.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 709 LEARQVKASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDE----TAF 783
Cdd:cd07962 27 LEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYLELVKPRLYGEDEeekkAAR 106
|
90 100
....*....|....*....|....*....
gi 2161621985 784 NTLYTALEVLCRVMAPLAPMETETIWRGL 812
Cdd:cd07962 107 ATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
475-824 |
5.22e-14 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 76.63 E-value: 5.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 475 RDWSISRNRYWGSPIPVW---------VSDD--P-AYPRVDVYGSLAE--LKRdfgryptddkgkinlHRPWVdsltrpN 540
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIhcedcgvvpVPEDqlPvELPEDVDFDPTGGspLAR---------------APEWV------N 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 541 PDDPTGKSTMRRISDVLDCWFESgSMPFAQF---HY---PFENKEYfeqhfpgDY---VVEYIG----------QTRgwF 601
Cdd:COG0495 479 VTCPKCGGPARRETDTMDTFVDS-SWYYLRYtdpHNdeaPFDPEAA-------NYwlpVDQYIGgiehailhllYAR--F 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 602 YT--LHIMaGAL-FDSPaFRNVICHGIV--LGSDG------QKMSKHLRNYPDVNGVFNKYGSDAMRWFLMS-SPILRGg 669
Cdd:COG0495 549 FTkvLRDL-GLVsFDEP-FKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFaGPPERD- 625
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 670 nlivtaggirdtvrqimLPlWSTyyfftlyanaahdgQGLEA---------------RQVKASEVGSLSRMDRYLLARTH 734
Cdd:COG0495 626 -----------------LE-WSD--------------SGVEGayrflnrvwrlvvdeAEALKLDVADLSEADKELRRALH 673
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 735 NLVSSVETSLDQF----AISdacdAVADYIDLLTNWYVRNSRDRFwnedetafnTLYTALEVLCRVMAPLAPMETETIWR 810
Cdd:COG0495 674 KTIKKVTEDIERLrfntAIA----ALMELVNALYKAKDSGEADRA---------VLREALETLVLLLAPFAPHIAEELWE 740
|
410
....*....|....
gi 2161621985 811 GLTGGESVHLTDWP 824
Cdd:COG0495 741 RLGHEGSVADAPWP 754
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
420-832 |
1.02e-13 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 75.15 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 420 PHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEINWIPDNVKdGQFGKWLSNA-RDWSISRNRYWGSPIPvwvsDDPA 498
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVR-NEVLSWLKEGlQDLSISRDFDWGIPVP----GDPG 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 499 YprVdVYGslaelkrdfgryptddkgkinlhrpWVDSLTRPnpddptgkstmrrISdVLDCWFESGSMP--FAQFhYPFE 576
Cdd:COG0143 244 K--V-FYV-------------------------WFDALIGY-------------IS-ATKGYADDRGLPedFEKY-WPAP 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 577 NKEYFeqHFpgdyvveyIGQ--TRgwFYTLhimagaLFdsPAF---------RNVICHGIVLgSDGQKMSKHLRNYPDVN 645
Cdd:COG0143 281 DTELV--HF--------IGKdiIR--FHAI------IW--PAMlmaaglplpKKVFAHGFLT-VEGEKMSKSRGNVIDPD 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 646 GVFNKYGSDAMRWFLMSspilrggnlivTAGGIRDTVrqimlplwstyyfFTL--------------YANAAH------- 704
Cdd:COG0143 340 DLLDRYGPDALRYYLLR-----------EVPFGQDGD-------------FSWedfvarvnsdlandLGNLASrtlsmih 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 705 ---DGqglearqvKASEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYIDlLTN--------WYVRNSRD 773
Cdd:COG0143 396 kyfDG--------KVPEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALAR-AANkyidetapWKLAKDED 466
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2161621985 774 RfwneDETAfNTLYTALEVLCRVM---APLAPMETETIWRGL-TGGESVHLTDWPYLTEQGHK 832
Cdd:COG0143 467 P----ERLA-TVLYTLLEALRILAillKPFLPETAEKILEQLgLEGDELTWEDAGWPLPAGHK 524
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
420-812 |
2.36e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 73.76 E-value: 2.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 420 PHCWRCGTPLIYKPVSSWFVAVSKIKDRLLAHNQEI-NWI-PDN--------VKDGQfgkwlsnaRDWSISRNRY-WGsp 488
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLELYEANpDFIqPASrrnevisfVKSGL--------KDLSISRTNFdWG-- 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 489 IPVwvsddpayprvdvygslaelkrdfgryPTDDKgkinlHRP--WVDSLTrpNpddptgkstmrRISDVLdcwfesgsm 566
Cdd:PRK11893 212 IPV---------------------------PGDPK-----HVIyvWFDALT--N-----------YLTALG--------- 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 567 pfaqfhYPFENKEY---FEQHFPGDyvVEYIGQ--TRgwFYTLH--IMAGALfDSPAFRNVICHG-IVLgsDGQKMSKHL 638
Cdd:PRK11893 238 ------YPDDEELLaelFNKYWPAD--VHLIGKdiLR--FHAVYwpAFLMAA-GLPLPKRVFAHGfLTL--DGEKMSKSL 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 639 RNYPDVNGVFNKYGSDAMRWFLMS-SPILRGGNLIVTAggIRDTVRQImlplwstyyFFTLYANAAHDGQGLEARQVKAS 717
Cdd:PRK11893 305 GNVIDPFDLVDEYGVDAVRYFLLReIPFGQDGDFSREA--FINRINAD---------LANDLGNLAQRTLSMIAKNFDGK 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 718 --EVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVAD-------YIDLLTNWyvrnsrdRFWNEDETAFNT-LY 787
Cdd:PRK11893 374 vpEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILAlvraankYIDEQAPW-------SLAKTDPERLATvLY 446
|
410 420
....*....|....*....|....*....
gi 2161621985 788 TALEVLcRVMA----PLAPMETETIWRGL 812
Cdd:PRK11893 447 TLLEVL-RGIAvllqPVMPELAAKILDQL 474
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
423-663 |
4.51e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 68.43 E-value: 4.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 423 WRCGtpLIYK---PV------SSWFVAVS--KIKDRLLAHNQEINWIPDNVKDGQfgkwlsnaRDW-SISRNRYWGSPIP 490
Cdd:cd00812 111 YEKG--LAYKkeaPVnwckllDQWFLKYSetEWKEKLLKDLEKLDGWPEEVRAMQ--------ENWiGCSRQRYWGTPIP 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 491 V-WVSD-------------DPAYPRVDVYGSLAELKRDFGR-YPTDDK--GK--INLHrpwvdsltrpnpddptgkstmr 551
Cdd:cd00812 181 WtDTMEslsdstwyyarytDAHNLEQPYEGDLEFDREEFEYwYPVDIYigGKehAPNH---------------------- 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 552 risdvldcwfesgsMPFAQFHYPFenkeyfeqHFPGDYVVEYigqtrgWFytlhimagalfdspafRNVICHGIVLGsDG 631
Cdd:cd00812 239 --------------LLYSRFNHKA--------LFDEGLVTDE------PP----------------KGLIVQGMVLL-EG 273
|
250 260 270
....*....|....*....|....*....|..
gi 2161621985 632 QKMSKHLRNYPDVNGVFNKYGSDAMRWFLMSS 663
Cdd:cd00812 274 EKMSKSKGNVVTPDEAIKKYGADAARLYILFA 305
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
722-859 |
1.16e-11 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 64.47 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 722 LSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYI-DLLTNWYVRNSRDRFWNEDETAFN------TLYTALEVLC 794
Cdd:cd07960 42 LLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYLDIIKDRLYCDAKDSLErrsaqtVLYHILDALL 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2161621985 795 RVMAPLAPMETETIWR---GLTGGESVHLTDWPylteqghkDAPQTKLgqvlrqDDGLVAAMEKVREV 859
Cdd:cd07960 122 KLLAPILPFTAEEVWEhlpGEKKEESVFLEDWP--------ELPEEWK------DEELEEKWEKLLAL 175
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-182 |
3.44e-11 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 65.73 E-value: 3.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 48 PFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAEleaekelGIENKSQIDKMGLAAFNdacrrsvlky 127
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE-------NAAIKIGRDPEDWTEYN---------- 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2161621985 128 TNEWKDYVHRQARWVDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPYC 182
Cdd:cd00812 72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
48-189 |
9.30e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 65.94 E-value: 9.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 48 PFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEKElGIENKSQIDKMG------LAAFNdacr 121
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE-GITPEELIARYHaehkrdFAGFG---- 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2161621985 122 rsvlkytnewkdyvhrqarwVDFDNGYKTLDTTYMEsviWA---FKQLYEKGLAYKgyRVLP--YCPKDETPL 189
Cdd:PRK00133 86 --------------------ISFDNYGSTHSEENRE---LAqeiYLKLKENGYIYE--KTIEqlYDPEKGMFL 133
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
403-662 |
3.02e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.85 E-value: 3.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 403 EDHRAFlVQ-------ERSYI----HSYPHCWRCGTPL-IYKPVSSWFVAVSKIKDRLLAH---NQEINWiPDNVKDgQF 467
Cdd:cd00814 95 PRHKEI-VQeffkklyENGYIyegeYEGLYCVSCERFLpEWREEEHYFFRLSKFQDRLLEWlekNPDFIW-PENARN-EV 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 468 GKWLSNA-RDWSISR-NRYWGspIPVwvsddpayprvdvygslaelkrdfgryPTDDKGKINLhrpWVDSLtrpnpddpt 545
Cdd:cd00814 172 LSWLKEGlKDLSITRdLFDWG--IPV---------------------------PLDPGKVIYV---WFDAL--------- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 546 gkstMRRISdVLDCWFEsgsmpfaqfhyPFENKEYFEQHFPGDYVVeyIGQTRGWFYTLH--IMAGALfDSPAFRNVICH 623
Cdd:cd00814 211 ----IGYIS-ATGYYNE-----------EWGNSWWWKDGWPELVHF--IGKDIIRFHAIYwpAMLLGA-GLPLPTRIVAH 271
|
250 260 270
....*....|....*....|....*....|....*....
gi 2161621985 624 GIVLgSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLMS 662
Cdd:cd00814 272 GYLT-VEGKKMSKSRGNVVDPDDLLERYGADALRYYLLR 309
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
47-198 |
4.89e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 56.81 E-value: 4.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 47 PPFANGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAELEAEkELGIENKsqidkmglaafnDACRRSVLK 126
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAE-EAGISPQ------------ELADRNSAA 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2161621985 127 YTNEWKDYVhrqarwVDFDNGYKTLDTTYMESVIWAFKQLYEKGLAYKGYRVLPYCPKDETPLSNHELRMDA 198
Cdd:PRK11893 76 FKRLWEALN------ISYDDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDG 141
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
51-187 |
6.42e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 53.65 E-value: 6.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 51 NGLPHYGHLLTGYAKDVIPRYQTMKGRRVNRVFGWDTHGLPAElEAEKELGIENKSQIDKMglaafndacrrsVLKYTNE 130
Cdd:PRK12267 16 NGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQ-QAAEKAGKTPQEYVDEI------------SAGFKEL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2161621985 131 WKdyvhrqarwvDFDNGY----KTLDTTYMESVIWAFKQLYEKGLAYKG-YRVLpYCPKDET 187
Cdd:PRK12267 83 WK----------KLDISYdkfiRTTDERHKKVVQKIFEKLYEQGDIYKGeYEGW-YCVSCET 133
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
725-801 |
2.15e-06 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 47.50 E-value: 2.15e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2161621985 725 MDRYLLARTHNLVSSVETSLDQFAISDACDAVADYIDLLtNWYVRNSRDRFWNE--DETAFNTLYTALEVLCRVMAPLA 801
Cdd:cd07375 40 ADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLDELKPALQTEelREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
573-837 |
3.96e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 50.95 E-value: 3.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 573 YPFENKEYFEQHFPGDyvVEYIGQ--TRgwFYTLH--IMAGALfDSPAFRNVICHGIVLgSDGQKMSKHLRN--YPDVng 646
Cdd:PRK12267 241 YGSDDDELFKKFWPAD--VHLVGKdiLR--FHAIYwpIMLMAL-GLPLPKKVFAHGWWL-MKDGKMSKSKGNvvDPEE-- 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 647 VFNKYGSDAMRWFLM-----------SSPILRG----------GNL---IVTaggirdtvrqiMlplwSTYYFftlyana 702
Cdd:PRK12267 313 LVDRYGLDALRYYLLrevpfgsdgdfSPEALVErinsdlandlGNLlnrTVA-----------M----INKYF------- 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 703 ahDGqglearQVKASevGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVADYIDlLTNWYVrnsrdrfwneDETA 782
Cdd:PRK12267 371 --DG------EIPAP--GNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLIS-RANKYI----------DETA 429
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2161621985 783 --------------FNTLYTALEVLcRVMA----PLAPMETETIWRGLtgGESVHLTDWPYLTEQGHKDAPQT 837
Cdd:PRK12267 430 pwvlakdegkkerlATVMYHLAESL-RKVAvllsPFMPETSKKIFEQL--GLEEELTSWESLLEWGGLPAGTK 499
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
717-810 |
2.65e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 38.73 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 717 SEVGSLSRMDRYLLARTHNLVSSVETSLDQFAISDACDAVadYIDLLT--NWYVRNSRDRFwNEDetafnTLYTALEVLC 794
Cdd:cd07959 28 GELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEG--LYELQNdlDWYRERGGAGM-NKD-----LLRRFIEVWT 99
|
90
....*....|....*.
gi 2161621985 795 RVMAPLAPMETETIWR 810
Cdd:cd07959 100 RLLAPFAPHLAEEIWH 115
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
610-663 |
3.19e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 40.25 E-value: 3.19e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2161621985 610 ALFDSPaFRNVICHGIVLGSDGQKMSKHLRNYPDVNGVFNKYGSDAMRWFLMSS 663
Cdd:cd00672 152 AATGKP-FARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
420-493 |
6.74e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 40.52 E-value: 6.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161621985 420 PHCWRCGTPLIYKPVSSWFVAVSKIKDRL---LAHNQEinwIPDNVKdGQFGKWLSNA-RDWSISRN-RYWGSPIP---- 490
Cdd:PRK00133 170 PKSAISGATPVLKESEHFFFKLPRFEEFLkewITRSGE---LQPNVA-NKMKEWLEEGlQDWDISRDaPYFGFEIPgapg 245
|
....*..
gi 2161621985 491 ----VWV 493
Cdd:PRK00133 246 kvfyVWL 252
|
|
| |
