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Conserved domains on  [gi|2161015912|ref|WP_231050614|]
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polyphosphate--glucose phosphotransferase [Curtobacterium sp. C1]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 6-245 2.23e-118

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


:

Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 337.62  E-value: 2.23e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDVTTGELQTDRIKKATPEGGKPHDIVAVAKSILDELapGADVPVGVCFPAIVRDGKTMSAANVSK 85
Cdd:cd24058     2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHF--PWFGPVGVGFPGVVRRGVVRTAANLDK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  86 KWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVTTLGTGIGTALINDGVLIVNSELGHLEIDGHDA 165
Cdd:cd24058    80 SWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 166 ESRASFAAKERDELSWKHWAKRLQKYYSTLEALLSPELFVVGGGVSKHHEEFLPLLDLQAGIIPATLRNNAGIIGAATLA 245
Cdd:cd24058   160 EERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 6-245 2.23e-118

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 337.62  E-value: 2.23e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDVTTGELQTDRIKKATPEGGKPHDIVAVAKSILDELapGADVPVGVCFPAIVRDGKTMSAANVSK 85
Cdd:cd24058     2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHF--PWFGPVGVGFPGVVRRGVVRTAANLDK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  86 KWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVTTLGTGIGTALINDGVLIVNSELGHLEIDGHDA 165
Cdd:cd24058    80 SWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 166 ESRASFAAKERDELSWKHWAKRLQKYYSTLEALLSPELFVVGGGVSKHHEEFLPLLDLQAGIIPATLRNNAGIIGAATLA 245
Cdd:cd24058   160 EERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 1-245 2.20e-40

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 140.80  E-value: 2.20e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   1 MTSLAVGVDIGGTGIKGAIVDVTTGELQTDRIkkATPEGGKPHDIVAVAKSILDELAPGADVP------VGVCFPAIV-R 73
Cdd:COG1940     3 DAGYVIGIDIGGTKIKAALVDLDGEVLARERI--PTPAGAGPEAVLEAIAELIEELLAEAGISrgrilgIGIGVPGPVdP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  74 DGKTMSAANVSKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS 153
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYL-TLGTGIGGGIVINGKLLRGA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 154 -----ELGHLEIDGHDA----------ESRASF-----------------------AAKERDELS---WKHWAKRLQKYY 192
Cdd:COG1940   160 ngnagEIGHMPVDPDGPlcgcgnrgclETYASGpallrrarelggaekltaeelfaAARAGDPLAlevLDEAARYLGIGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2161015912 193 STLEALLSPELFVVGGGVSKHHEEFLPLLDLQAG------------IIPATLRNNAGIIGAATLA 245
Cdd:COG1940   240 ANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAkyalpparedprIVPASLGDDAGLLGAAALA 304
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 6-245 1.35e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 98.95  E-value: 1.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDvTTGElQTDRIKKATPEGGKPHDIVAVAKSILDEL--APGADVPVGVCFPAIVRDGKTMSAANV 83
Cdd:pfam00480   1 IGIDIGGTKIAAALFD-EEGE-ILARERVPTPTTTTEETLVDAIAFFVDSAqrKFGELIAVGIGSPGLISPKYGYITNTP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  84 SKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLI-----VNSELGHL 158
Cdd:pfam00480  79 NIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYV-TVGTGVGGGVISNGKLFtgrngVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 159 EIDGHDA----------ESRASFAAKERD------------------------ELSWKHWAKRLQKYYSTLEALLSPELF 204
Cdd:pfam00480 158 QLDPNGPkcgcgnhgclETIASGRALEKRyqqkgedlegkdiivlaeqgdevaEEAVERLARYLAKAIANLINLFDPQAI 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2161015912 205 VVGGGVSkHHEEFLPLLDLQ-------------AGIIPATLRNNAGIIGAATLA 245
Cdd:pfam00480 238 VLGGGVS-NADGLLEAIRSLvkkylngylpvppVIIVAASLGDNAGALGAAALA 290
PRK09698 PRK09698
D-allose kinase; Provisional
 1-247 6.89e-09

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 54.99  E-value: 6.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   1 MTSLAVGVDIGGTGIKGAIVDVTTGELQTDriKKATPEGGKPHDIVAVAKSILDELAPGADVP--VGVCFPAIV-RDGKT 77
Cdd:PRK09698    2 QKNVVLGIDMGGTHIRFCLVDAEGEILHCE--KKRTAEVIAPDLVSGLGEMIDEYLRRFNARChgIVMGFPALVsKDRRT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  78 -MSAANVSKKWIGFE-AEALFEKELGRSIHFVNDA------DAAGFAEQQfgaargkeGLVVVTTLGTGIGTALINDGVL 149
Cdd:PRK09698   80 vISTPNLPLTALDLYdLADKLENTLNCPVFFSRDVnlqllwDVKENNLTQ--------QLVLGAYLGTGMGFAVWMNGAP 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 150 I-----VNSELGH--LEIDGH--------DAESRASFAAKER-------------------DELSWKHWAKRLQKYYSTL 195
Cdd:PRK09698  152 WtgahgVAGELGHipLGDMTQhcgcgnpgCLETNCSGMALRRwyeqqprdyplsdlfvhagDHPFIQSLLENLARAIATS 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2161015912 196 EALLSPELFVVGGGV---------------SKHHEEFLPLLDLQagIIPATLRNNAGIIGAATLAAR 247
Cdd:PRK09698  232 INLFDPDAIILGGGVmdmpafpretliamiQKYLRKPLPYEVVR--FIYASSSDFNGAQGAAILAHQ 296
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 6-245 2.23e-118

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 337.62  E-value: 2.23e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDVTTGELQTDRIKKATPEGGKPHDIVAVAKSILDELapGADVPVGVCFPAIVRDGKTMSAANVSK 85
Cdd:cd24058     2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHF--PWFGPVGVGFPGVVRRGVVRTAANLDK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  86 KWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVTTLGTGIGTALINDGVLIVNSELGHLEIDGHDA 165
Cdd:cd24058    80 SWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 166 ESRASFAAKERDELSWKHWAKRLQKYYSTLEALLSPELFVVGGGVSKHHEEFLPLLDLQAGIIPATLRNNAGIIGAATLA 245
Cdd:cd24058   160 EERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 1-245 2.20e-40

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 140.80  E-value: 2.20e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   1 MTSLAVGVDIGGTGIKGAIVDVTTGELQTDRIkkATPEGGKPHDIVAVAKSILDELAPGADVP------VGVCFPAIV-R 73
Cdd:COG1940     3 DAGYVIGIDIGGTKIKAALVDLDGEVLARERI--PTPAGAGPEAVLEAIAELIEELLAEAGISrgrilgIGIGVPGPVdP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  74 DGKTMSAANVSKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS 153
Cdd:COG1940    81 ETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYL-TLGTGIGGGIVINGKLLRGA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 154 -----ELGHLEIDGHDA----------ESRASF-----------------------AAKERDELS---WKHWAKRLQKYY 192
Cdd:COG1940   160 ngnagEIGHMPVDPDGPlcgcgnrgclETYASGpallrrarelggaekltaeelfaAARAGDPLAlevLDEAARYLGIGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2161015912 193 STLEALLSPELFVVGGGVSKHHEEFLPLLDLQAG------------IIPATLRNNAGIIGAATLA 245
Cdd:COG1940   240 ANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAkyalpparedprIVPASLGDDAGLLGAAALA 304
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 6-244 9.52e-38

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 132.20  E-value: 9.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDVTtGELqTDRIKKATPEGGKPHDIVAVAKSILDELAPGADVP-----VGVCFPAIV--RDGKTM 78
Cdd:cd23763     1 IGIDIGGTKIRAALVDLD-GEI-LARERVPTPAEEGPEAVLDRIAELIEELLAEAGVRerilgIGIGVPGPVdpETGIVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  79 SAANVsKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS----- 153
Cdd:cd23763    79 FAPNL-PWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYI-TLGTGIGGGIIIDGKLYRGAngaag 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 154 ELGHLEIdghdaesrasfaakerdelsWKHWAKRLQKYYSTLEALLSPELFVVGGGVSKHHEEFLPLLDLQAG------- 226
Cdd:cd23763   157 EIGHITV--------------------LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRrralppl 216

                         250       260
                  ....*....|....*....|...
gi 2161015912 227 -----IIPATLRNNAGIIGAATL 244
Cdd:cd23763   217 rrrvrIVPSELGDDAGLLGAAAL 239
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 4-242 8.21e-28

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 107.64  E-value: 8.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   4 LAVGVDIGGTGIKGAIVDvTTGELQtDRIKKATPEGGKPHDIVAVAKSILDELAPGADVP-VGVCFPAIV--RDGKTMSA 80
Cdd:cd24068     1 KILGIDIGGTKIKYGLVD-ADGEIL-EKDSVPTPASKGGDAILERLLEIIAELKEKYDIEgIGISSAGQVdpKTGEVIYA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  81 ANVSKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS-----EL 155
Cdd:cd24068    79 TDNLPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCL-TLGTGIGGAIILDGRLYRGAngsagEL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 156 GHLEIDGHDA----------ESRAS----------------------FAAKERDELSWKH----WAKRLQKYYSTLEALL 199
Cdd:cd24068   158 GHMVVDPGGRpcccggkgclEQYASgtalvrrvaealgepgidgreiFDLADAGDPLAKEvveeFAEDLATGLANLVHIF 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2161015912 200 SPELFVVGGGVSKHHEEFLPLL------------DLQAGIIPATLRNNAGIIGAA 242
Cdd:cd24068   238 DPEVIVIGGGISAQGELFLEELreelrkllmpplLDATKIEPAKLGNDAGLLGAA 292
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 5-245 2.35e-26

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 103.97  E-value: 2.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   5 AVGVDIGGTGIKGAIVDvTTGELqTDRIKKATPEGgkPHDIVAVAKSILDELAPGADVP-VGVCFPAIV-RDGKTM-SAA 81
Cdd:cd24061     1 TIGVDIGGTKIAAGVVD-EEGEI-LATERVPTPPT--ADGIVDAIVEAVEELREGHDVSaVGVAAAGFVdADRATVlFAP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  82 NVSkkWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLI-----VNSELG 156
Cdd:cd24061    77 NIA--WRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMI-TVGTGLGGGIVIGGKLLrgafgIAGEFG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 157 HLEI--DGH------------------------------DAESRASFAAKERDELSWKH------------------WAK 186
Cdd:cd24061   154 HIRVvpDGLlcgcgsrgcweqyasgralvryakeaanatPEGAAVLLADGSVDGITGKHiseaaragdpvaldalreLAR 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2161015912 187 RLQKYYSTLEALLSPELFVVGGGVSKHHEEFLPLLDL-------------QAGIIPATLRNNAGIIGAATLA 245
Cdd:cd24061   234 WLGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIREaferwlpgrgwrpIPRLRTAQLGNDAGLIGAADLA 305
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 6-245 1.35e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 98.95  E-value: 1.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDvTTGElQTDRIKKATPEGGKPHDIVAVAKSILDEL--APGADVPVGVCFPAIVRDGKTMSAANV 83
Cdd:pfam00480   1 IGIDIGGTKIAAALFD-EEGE-ILARERVPTPTTTTEETLVDAIAFFVDSAqrKFGELIAVGIGSPGLISPKYGYITNTP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  84 SKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLI-----VNSELGHL 158
Cdd:pfam00480  79 NIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYV-TVGTGVGGGVISNGKLFtgrngVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 159 EIDGHDA----------ESRASFAAKERD------------------------ELSWKHWAKRLQKYYSTLEALLSPELF 204
Cdd:pfam00480 158 QLDPNGPkcgcgnhgclETIASGRALEKRyqqkgedlegkdiivlaeqgdevaEEAVERLARYLAKAIANLINLFDPQAI 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2161015912 205 VVGGGVSkHHEEFLPLLDLQ-------------AGIIPATLRNNAGIIGAATLA 245
Cdd:pfam00480 238 VLGGGVS-NADGLLEAIRSLvkkylngylpvppVIIVAASLGDNAGALGAAALA 290
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 9-241 2.84e-23

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 95.33  E-value: 2.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   9 DIGGTGIKGAIVDVTTGELQTDRIKkaTPEGGKPhDIVAVAKSILDELAPGADVpVGVCFPAIV--RDGKTMSAANVSKk 86
Cdd:cd24152     6 DIGGTFIKYALVDENGNIIKKGKIP--TPKDSLE-EFLDYIKKIIKRYDEEIDG-IAISAPGVIdpETGIIYGGGALPY- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  87 WIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDG------------------- 147
Cdd:cd24152    81 LKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVI-VLGTGIGGAIIIDGklyrgshffagefsylltd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 148 ------------------VLIVNSELGHLEIDGHDAesrasF-AAKERDELSWKH---WAKRLQKYYSTLEALLSPELFV 205
Cdd:cd24152   160 dddkdllffsglasmfglVKRYNKAKGLEPLDGEEI-----FeKYAKGDEAAKKIldeYIRNLAKLIYNIQYILDPEVIV 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2161015912 206 VGGGVS----------KHHEEFL---PLLDLQAGIIPATLRNNAGIIGA 241
Cdd:cd24152   235 IGGGISeqplfiedlkKEVNEILanrPGSIPKPEIKACKFGNDANLLGA 283
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 5-244 7.49e-23

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 94.71  E-value: 7.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   5 AVGVDIGGTGIKGAIVDVTTGELQTDRIKkaTPEGGKPHDIVAVAKSILDELAPGAD------VPVGVCFPAIVRDGKTM 78
Cdd:cd24063     2 YVAVDIGGTWIRAGLVDEDGRILLKIRQP--TPKTGDPGTVSEQVLGLIETLLSKAGkdsiegIGVSSAGPLDLRKGTIV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  79 SAANVSKKWIGFEaEALFEkELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS----- 153
Cdd:cd24063    80 NSPNIKGKEIPLV-EPLKE-EFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYI-TISTGIGGGVIVDGRLLLGKngnaa 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 154 ELGHLEIDGHD-----------------------------------------------AESRASFAAKERDELSWKHWAK 186
Cdd:cd24063   157 EVGHLVVDTESglkcgcggyghweafasgrgiprfarewaegfssrtslklrnpggegITAKEVFSAARKGDPLALKIIE 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2161015912 187 RLQKY----YSTLEALLSPELFVVGGGVSKHHEEFL-----PLLDLQA-----GIIPATLRNNAGIIGAATL 244
Cdd:cd24063   237 KLARYngrgIANVINAYDPELIVIGGSVFNNNKDILdplieYLEKNPAiskgpEIVLSELGDDVGLIGALAL 308
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 4-244 2.96e-22

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 93.12  E-value: 2.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   4 LAVGVDIGGTGIKGAIVDvTTGELQtDRIKKATP-EGGKPHDIVAVAKSI---LDELAPGAD----VPVGVCFPAIVRDG 75
Cdd:cd24062     1 WIVGIDVGGTTIKMAFLT-QEGEIV-QKWEIPTNkLEGGENIITDIAESIqqlLEELGYSKEdligIGVGVPGPVDVETG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  76 KTMSAANVSkkWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLI----- 150
Cdd:cd24062    79 TVEVAVNLG--WKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFI-TLGTGVGGGVIANGKIVhgang 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 151 VNSELGH---------------------------------LEIDGHDAESRASF--------------AAKERDELSWK- 182
Cdd:cd24062   156 AAGEIGHitvnpeggapcncgktgcletvasatgivriarEELEEGKGSSALRIlalggeltakdvfeAAKAGDELALAv 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2161015912 183 --HWAKRLQKYYSTLEALLSPELFVVGGGVS-----------KHHEEF-LPLLDLQAGIIPATLRNNAGIIGAATL 244
Cdd:cd24062   236 vdTVARYLGLALANLANTLNPEKIVIGGGVSaagefllspvkEYFDRFtFPRVRQDTEIVLATLGNDAGVIGAAWL 311
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 6-242 2.67e-20

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 87.38  E-value: 2.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDvttGELQTDRIKKATP-EGGKP-HDIVAVAKSILDELAPGAD-VPVGVCFPAIVRDGKTMSAAN 82
Cdd:cd24065     3 IGLDLGGTKIAAGVVD---GGRILSRLVVPTPrEGGEAvLDALARAVEALQAEAPGVEaVGLGVPGPLDFRRGRVRFAPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  83 VsKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLI-----VNSELGH 157
Cdd:cd24065    80 I-PGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYV-TISTGIGGGLVLGGRVLrgrhgQAGEIGH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 158 LEI--------DGHDA--ESRASFAAKERD-------ELSWKHWAKRLQK------------------YYSTLEALLSPE 202
Cdd:cd24065   158 TTVlpggpmcgCGLVGclEALASGRALARDasfaygrPMSTAELFELAQQgepkalriveqaaahlgiGLANLQKALDPE 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2161015912 203 LFVVGGGVSKHHEEFlpLLDLQAG------------IIPATLRNNAGIIGAA 242
Cdd:cd24065   238 VFVLGGGVAQVGDYY--LLPVQEAarrytegwhappLRLAHLGTDAGVIGAA 287
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 8-244 8.75e-18

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 80.41  E-value: 8.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   8 VDIGGTGIKGAIVDvtTGELQtDRIKKATPEGGKPHDIVAVAKSILDELAPGADvPVGVCFPAIVRDGKtMSAANVSKKW 87
Cdd:cd24069     3 IDIGGTKIAAALIG--NGQII-DRRQIPTPRSGTPEALADALASLLADYQGQFD-RVAVASTGIIRDGV-LTALNPKNLG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  88 I--GFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNSE-----LGHLEI 160
Cdd:cd24069    78 GlsGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFI-TVSTGVGGGLVLNGQLLTGPNglaghIGHTLA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 161 DGHDA----------ESRAS---------------FAAKERDELSWKH--WAKRLQK--------YYSTLEALLSPELFV 205
Cdd:cd24069   157 DPPGPvcgcgrrgcvEAIASgtaiaaaaseilgepVDAKDVFERARSGdeEAARLIDraaraladLIADLKATLDLDCVV 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2161015912 206 VGGGVSKhHEEFLPLLDL---------QAGIIPATLRNNAGIIGAATL 244
Cdd:cd24069   237 IGGSVGL-AEGFLERVEQyladepaifRVSLEPARLGQDAGLLGAALL 283
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 4-165 5.20e-15

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 72.98  E-value: 5.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   4 LAVGVDIGGTGIKGAIVDVTtGELQTdRIKKATPEGGKPHDIVAVAKSILDELAPGADVP------VGVCFPAIV--RDG 75
Cdd:cd24076     2 AVIGVELGVDYITVVVTDLA-GEVLW-RREVPLPASDDPDEVLAQLAALIREALAAAPDSplgilgIGVGVPGLVdsEDG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  76 KTMSAANVskKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS-- 153
Cdd:cd24076    80 VVLLAPNL--GWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYL-SAGVGIGAGIILDGELYRGAsg 156

                         170
                  ....*....|....*
gi 2161015912 154 ---ELGHLEIDGHDA 165
Cdd:cd24076   157 fagEIGHMTVDPDGP 171
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 6-245 2.54e-14

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 70.66  E-value: 2.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDVtTGELQTDRIKKATPEGGKPHDIVAVAKSILDELAPGADVPVGVC--FPAIV-RDGKT-MSAA 81
Cdd:cd24070     4 LGIDIGGTNIRIGLVDE-DGKLLDFEKVPSKDLLRAGDPVEVLADLIREYIEEAGLKPAAIVigVPGTVdKDRRTvISTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  82 NVsKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGkEGLVVVTTLGTGIGTA-LINDGVLI----VNSELG 156
Cdd:cd24070    83 NI-PGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDD-EGVVLGFYIGTGIGNAiLINGKPLRgkngVAGELG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 157 HLEIDGHD----------AESRASFAAKER-----------DELSWKH-WAKRLQKY-------YSTLEALLSPELFVVG 207
Cdd:cd24070   161 HIPVYGNGkpcgcgntgcLETYASGRALEEiaeehypdtpiLDIFVDHgDEPELDEFvedlalaIATEINILDPDAVILG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2161015912 208 GGVSKHH-------EEF--------LPLLDLQagIIPATLRNNAGIIGAATLA 245
Cdd:cd24070   241 GGVIDMKgfpretlEEYirkhlrkpYPADNLK--IIYAELGPEAGVIGAAIYA 291
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 7-158 1.64e-13

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 68.41  E-value: 1.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   7 GVDIGGTGIKGAIVDVTTGELQTDRIkkATPEggkpHDIVAVAKSILDELAP-----GADVPVGVCFPAIV-RDGKTMSA 80
Cdd:cd24057     4 GFDIGGTKIEFAVFDEALQLVWTKRV--PTPT----DDYAAFLAAIAELVAEadarfGVKGPVGIGIPGVIdPEDGTLIT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  81 ANVSKKwIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEgLVVVTTLGTGIGTALINDGVLI-----VNSEL 155
Cdd:cd24057    78 ANIPAA-KGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYP-SVFGLILGTGVGGGLVVNGRLVggrsgIAGEW 155


                  ...
gi 2161015912 156 GHL 158
Cdd:cd24057   156 GHG 158
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 5-244 2.27e-13

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 68.29  E-value: 2.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   5 AVGVDIGGTGIKGAIVDVTTGELQTDRIKKATpEGGKPHDIVAVAKSILdELAPGADVP-VGVCFP-AIVRDGKTMSAAN 82
Cdd:cd24064     1 VIGIDLGGTDTKIGIVDENGDILKKKTIDTKV-ENGKEDVINRIAETVN-ELIEEMELLgIGIGSPgSIDRENGIVRFSP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  83 VSKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGlVVVTTLGTGIGTALINDGVLI-----VNSELGH 157
Cdd:cd24064    79 NFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNH-IIGLTLGTGVGSGVICHGQLLtgydgIAAELGH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 158 LEIDGH------------DAESRASFAAKERDEL-----------SWKHWAKRLQKYYS------------TLEAL---- 198
Cdd:cd24064   158 VIVEPNgpicgcgnrgcvEAFASATAIIRYARESrkrypdslageSEKINAKHVFDAARkndplatmvfrrVVDALaiai 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2161015912 199 ------LSPELFVVGGGVS------------KHHEEFLPLLDLQAGIIPATLRNNAGIIGAATL 244
Cdd:cd24064   238 ggfvhiFNPEIIIIGGGISragsflldpireKTKKYVMLSFQDTYSIELSNLVEDAGILGAASI 301
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 6-244 7.35e-13

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 66.84  E-value: 7.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDVTTGELQTDRIkkATPEGGKPHDIVAVAKSILD-ELAPGADVPVGVCFPAIVrDGKTMSAANVS 84
Cdd:cd24066     2 IGIDLGGTKIEGIALDRAGRELLRRRV--PTPRGDYEATLDAIADLVEEaEEELGAPATVGIGTPGSI-SPRTGLVKNAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  85 KKW-IGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKeGLVVVTTLGTGIGTALINDGVLI-----VNSELGHL 158
Cdd:cd24066    79 STWlNGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGA-GVVFGVILGTGVGGGIVVNGRVLtgangIAGEWGHN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 159 EIDGHDAESRA----------------SFAAKERD-------------------------ELSWKHWAKRLQKYYSTLEA 197
Cdd:cd24066   158 PLPWPDEDELPgppcycgkrgcvetflSGPALERDyarltgktlsaeeivalaragdaaaVATLDRFLDRLGRALANVIN 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2161015912 198 LLSPELFVVGGGVSKHHEEFLPLLDLQAG----------IIPATLRNNAGIIGAATL 244
Cdd:cd24066   238 ILDPDVIVLGGGLSNIDELYTEGPAALARyvfsdevetpIVKNKHGDSSGVRGAAWL 294
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 85-244 3.32e-12

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 64.87  E-value: 3.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  85 KKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLI---VNSELGH---- 157
Cdd:cd24067    80 PGWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYI-TVGTGIGVGLVVNGKPVhglLHPEMGHirvp 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 158 -LEIDG--------HDA--ESRASFAA------KERDELSWKHWAKRLQKYY-----STLEALLSPELFVVGGGVSKH-- 213
Cdd:cd24067   159 rHPDDDgfpgvcpfHGDclEGLASGPAiaarwgIPAEELPDDHPAWDLEAYYlaqacANLTLTLSPERIVLGGGVMQRpg 238

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2161015912 214 -----HEEFLPLL-----------DLQAGIIPATLRNNAGIIGAATL 244
Cdd:cd24067   239 lfpriREKFRKLLngylevprllpDIDEYIVPPALGNDAGILGALAL 285
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 5-161 1.89e-09

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 57.04  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   5 AVGVDIGGTGIKGAIVdvttgELQTDRIKKAT-PEGGKPHDIVAVAKSILDELAPGAD------VPVGVCFPAIV--RDG 75
Cdd:cd24060     2 ALAVDLGGTNLRVAIV-----SMKGEIVKKYTqPNPKTYEERIDLILQMCVEAASEAVklncriLGVGISTGGRVnpREG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  76 KTMSAANVSKKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVTTlGTGIGTALINDGVLIVNS-- 153
Cdd:cd24060    77 IVLHSTKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVIT-GTGIGGGIILNHELIHGSsf 155

                         170
                  ....*....|.
gi 2161015912 154 ---ELGHLEID 161
Cdd:cd24060   156 caaELGHIVVS 166
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 5-245 5.30e-09

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 55.67  E-value: 5.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   5 AVGVDIGGTGIKGAIVDVTtGELQTdRIKKATPEGGKPHDIVAVAKSILDELAPGADVP-----VGVCFPAIVrDGKTMS 79
Cdd:cd24059     3 VIGVEIGRDLLSAVLCDLS-GNILA-REKYPLDEKENPEEVLEKLYELIDRLLEKENIKskilgIGIGAPGPL-DVEKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  80 AANVSK--KWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVN----- 152
Cdd:cd24059    80 ILNPPNfpGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYI-LADEGIGAGIIINGKLYRGvdgya 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 153 SELGHLEID---------------------------------GHDAESRASFAAKERDELSWKHwAKRLQKYYS----TL 195
Cdd:cd24059   159 GEIGHTSIDingprcscgnrgclelyasipaiekkarsalgsGRSFQLDIVEALQKGDPIADEV-IEEAAKYLGiglvNL 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2161015912 196 EALLSPELFVVGGGVSKHHEEFLPLL------------DLQAGIIPATLRNNAGIIGAATLA 245
Cdd:cd24059   238 INLLNPEAIIIGGELIYLGERYLEPIekevnsrlfgrnAREVRILKSSLGEDAPLLGAAALV 299
PRK09698 PRK09698
D-allose kinase; Provisional
 1-247 6.89e-09

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 54.99  E-value: 6.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   1 MTSLAVGVDIGGTGIKGAIVDVTTGELQTDriKKATPEGGKPHDIVAVAKSILDELAPGADVP--VGVCFPAIV-RDGKT 77
Cdd:PRK09698    2 QKNVVLGIDMGGTHIRFCLVDAEGEILHCE--KKRTAEVIAPDLVSGLGEMIDEYLRRFNARChgIVMGFPALVsKDRRT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  78 -MSAANVSKKWIGFE-AEALFEKELGRSIHFVNDA------DAAGFAEQQfgaargkeGLVVVTTLGTGIGTALINDGVL 149
Cdd:PRK09698   80 vISTPNLPLTALDLYdLADKLENTLNCPVFFSRDVnlqllwDVKENNLTQ--------QLVLGAYLGTGMGFAVWMNGAP 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 150 I-----VNSELGH--LEIDGH--------DAESRASFAAKER-------------------DELSWKHWAKRLQKYYSTL 195
Cdd:PRK09698  152 WtgahgVAGELGHipLGDMTQhcgcgnpgCLETNCSGMALRRwyeqqprdyplsdlfvhagDHPFIQSLLENLARAIATS 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2161015912 196 EALLSPELFVVGGGV---------------SKHHEEFLPLLDLQagIIPATLRNNAGIIGAATLAAR 247
Cdd:PRK09698  232 INLFDPDAIILGGGVmdmpafpretliamiQKYLRKPLPYEVVR--FIYASSSDFNGAQGAAILAHQ 296
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 1-250 1.11e-08

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 54.53  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   1 MTSLAVgvDIGGTGIKGAIVDVtTGELqTDRIKKATPEGGKPHDIVAVAKSILDELAPGADVpVGVCFPAIVRDGkTMSA 80
Cdd:PRK05082    1 MTTLAI--DIGGTKIAAALVGE-DGQI-RQRRQIPTPASQTPEALRQALSALVSPLQAQADR-VAVASTGIINDG-ILTA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  81 ANvsKKWIGFEAE----ALFEKELGRSIHFVNDADAAGFAEQQfgaARGKEGL-VVVTTLGTGIGTALINDGVLIVNS-- 153
Cdd:PRK05082   75 LN--PHNLGGLLHfplvQTLEQLTDLPTIALNDAQAAAWAEYQ---ALPDDIRnMVFITVSTGVGGGIVLNGKLLTGPgg 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912 154 ---ELGHLEIDGHDA----------ESRASFAAKERDELSWK------------------------HWAKRLQKYYSTLE 196
Cdd:PRK05082  150 lagHIGHTLADPHGPvcgcgrrgcvEAIASGRAIAAAAQGWLagcdaktiferagqgdeqaqalinRSAQAIARLIADLK 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2161015912 197 ALLSPELFVVGGGVS---------KHHEEFLPLLdLQAGIIPATLRNNAGIIGAATLAARSQQ 250
Cdd:PRK05082  230 ATLDCQCVVLGGSVGlaegylelvQAYLAQEPAI-YHVPLLAAHYRHDAGLLGAALWAQGEKL 291
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 4-161 2.88e-08

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 53.32  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   4 LAVGVDIGGTGIKGAIVDVTTGELQTDRIKKATPEggkPHDIVAVAKSILDELAPGADVP------VGVCFPAIV--RDG 75
Cdd:cd24073     2 YVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGD---PEAVAEAIAEAVAELLAQAGLSpdrllgIGVGLPGLVdaETG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  76 KTMSAANVskKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS-- 153
Cdd:cd24073    79 ICRWSPLL--GWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVV-TIGRGIGCGLVVDGRLYRGAhg 155

                         170
                  ....*....|.
gi 2161015912 154 ---ELGHLEID 161
Cdd:cd24073   156 gagEIGHTTVD 166
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 5-169 5.48e-08

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 52.61  E-value: 5.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   5 AVGVDIGGTGIKGAIVDVTTGELQTDRIKKAtpEGGKPHDIVAVAKSILDELapGADVPVGVCF--PAIVRDGKTmSAAN 82
Cdd:cd24008     1 ILVGDIGGTNARLALADAGDGSGDLLFVRKY--PSADFASLEDALAAFLAEL--GAPRPKAACIavAGPVDGGRV-RLTN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  83 VskKWIgFEAEALFEKELGRSIHFVNDADAAGFA------EQQF----GAARGKEGLVVVTTLGTGIGTALI----NDGV 148
Cdd:cd24008    76 L--DWS-IDAAELRKALGIGRVRLLNDFEAAAYGlpalgpEDLLvlygGGGPLPGGPRAVLGPGTGLGVALLvpdgDGGY 152

                         170       180
                  ....*....|....*....|.
gi 2161015912 149 LIVNSELGHLEIDGHDAESRA 169
Cdd:cd24008   153 VVLPSEGGHADFAPVTEEEAE 173
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 4-161 8.81e-08

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 51.90  E-value: 8.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   4 LAVGVDIGGTGIKGAIVDVTtGELqTDRIKKATPEGGKPHDIVAVAKSILDELAPGADVP-----VGVCFPAIV--RDGK 76
Cdd:cd24071     2 YIIGVKIEEGYLVLALTDLK-GKI-LEKTRIPFDHETDPEKVIELIAENIKKLIKNKHVEkkllgIGIAVSGLVdsKKGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  77 TMSAANVskKWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLIVNS--- 153
Cdd:cd24071    80 VIRSTIL--GWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICV-TVGAGIGSSLVIDGKLYTGNfgg 156

                         170
                  ....*....|
gi 2161015912 154 --ELGHLEID 161
Cdd:cd24071   157 agEIGHMTIQ 166
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 86-163 2.16e-05

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 44.71  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  86 KWIGFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVtTLGTGIGTALINDGVLI-----VNSELGHL-- 158
Cdd:cd24072    85 PWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVI-NLDYGIGSAIVIDNKLYigassGSGEIGHTkv 163


                  ....*
gi 2161015912 159 EIDGH 163
Cdd:cd24072   164 NPDGA 168
PRK09557 PRK09557
fructokinase; Reviewed
 6-147 9.00e-05

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 42.71  E-value: 9.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   6 VGVDIGGTGIKGAIVDVTTGELQTDRIkkATPEGGKPHDIVAVAKSILD-ELAPGADVPVGVCFPAIVrDGKTMSAANVS 84
Cdd:PRK09557    3 IGIDLGGTKIEVIALDDAGEELFRKRL--PTPRDDYQQTIEAIATLVDMaEQATGQRGTVGVGIPGSI-SPYTGLVKNAN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2161015912  85 KKWI-GFEAEALFEKELGRSIHFVNDADAAGFAEQQFGAARGKeGLVVVTTLGTGIGTALINDG 147
Cdd:PRK09557   80 STWLnGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGK-QTVFAVIIGTGCGAGVAING 142
ASKHA_NBD_HK cd24000
nucleotide-binding domain (NBD) of the hexokinase (HK) domain family; Hexokinase (EC 2.7.1.1) ...
 8-157 1.08e-04

nucleotide-binding domain (NBD) of the hexokinase (HK) domain family; Hexokinase (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). It can catalyze this reaction on glucose, fructose, sorbitol and glucosamine, and as such is the first step in a number of metabolic pathways. Hexokinase contains two structurally similar domains. Some members of the family have two copies of each of these domains. Hexokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466850 [Multi-domain]  Cd Length: 357  Bit Score: 42.65  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   8 VDIGGTGIKGAIVDVT-TGELQTDRIKKATPEGGKPHD-------IVAVAKSILDELAPGADVPVGVC--FPAI---VRD 74
Cdd:cd24000    48 IDLGGTNLRVALVSLDgKGIEVTISKKYEIPDEIKTASaeeffdfIADCIAEFLKENGLKKPLPLGFTfsFPLEqtsLND 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  75 GK--TMSAANVSKKWIGFEAEALFEKELGRS------IHFVNDADAAGFAeqqfGAARGKE---GLVvvttLGTGIGTAL 143
Cdd:cd24000   128 GKllSWTKGFKIPGVEGKDVGELLNDALKKRglpvkvVAVLNDTVATLLA----GAYKDPDcriGLI----LGTGTNAAY 199

                         170       180
                  ....*....|....*....|..
gi 2161015912 144 I--------NDGVLIVNSELGH 157
Cdd:cd24000   200 LeptsnillGDGGMIINTEWGN 221
ASKHA_NBD_FGGY_SHK cd07777
nucleotide-binding domain (NBD) of sedoheptulokinase (SHK) and similar proteins; SHK (EC 2.7.1. ...
 4-67 6.32e-04

nucleotide-binding domain (NBD) of sedoheptulokinase (SHK) and similar proteins; SHK (EC 2.7.1.14), also called heptulokinase, or carbohydrate kinase-like protein (CARKL), is encoded by the carbohydrate kinase-like (CARKL/SHPK) gene. It acts as a modulator of macrophage activation through control of glucose metabolism. SHK catalyzes the ATP-dependent phosphorylation of sedoheptulose to produce sedoheptulose 7-phosphate and ADP. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.


Pssm-ID: 466796 [Multi-domain]  Cd Length: 436  Bit Score: 40.67  E-value: 6.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2161015912   4 LAVGVDIGGTGIKGAIVDVTTGEL------QTDRIKKATPEGGK---PHDIVAVAKSILDELAPGADVPV---GVC 67
Cdd:cd07777     1 NVLGIDIGTTSIKAALLDLESGRIlesvsrPTPAPISSDDPGRSeqdPEKILEAVRNLIDELPREYLSDVtgiGIT 76
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 7-164 1.18e-03

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 39.24  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912   7 GVDIGGTGIKGAIVDVTTGELQTDRIkkATPEGGKPHdIVAVAKSILDELAP--GADVPVGVCFPAIVR-DGKTMSAANV 83
Cdd:PRK13311    4 GFDMGGTKIELGVFDENLQRIWHKRV--PTPREDYPQ-LLQILRDLTEEADTycGVQGSVGIGIPGLPNaDDGTVFTANV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161015912  84 SKKwIGFEAEALFEKELGRSIHFVNDADAAGFAEQ---QFGAARGKEGLVvvttLGTGIGTALINDGVLI-----VNSEL 155
Cdd:PRK13311   81 PSA-MGQPLQADLSRLIQREVRIDNDANCFALSEAwdpEFRTYPTVLGLI----LGTGVGGGLIVNGSIVsgrnhITGEF 155

                         170
                  ....*....|.
gi 2161015912 156 GH--LEIDGHD 164
Cdd:PRK13311  156 GHfrLPVDALD 166
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 92-163 5.48e-03

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 37.29  E-value: 5.48e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2161015912  92 AEALfEKELGRSIHFVNDADAAGFAEQQFGAARGKEGLVVVTtLGTGIGTALINDGVLIVNS-----ELGHLEIDGH 163
Cdd:cd24074    95 GEAL-EQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIV-IDDDIGAGVITDGQLLHAGssrlgELGHTQIDPY 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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